founders with the support of results4th call for projects neuroprion2010 salzburg
TRANSCRIPT
Founders
With the support of
Results4th
Call for Projects
NeuroPrion2010
Salzburg
2
Letters of intent
Independent evaluation and selection by the SAC Validation by the Bureau
Full Application
Independent evaluation and selection by the SAC
Proposal to the Bureau
Selection and validation by the Executive Committee
Selection process
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22
10
3
Selected Projects
UltraMab
High affinity anti-PrP monoclonal antibodies from PrP-negative hybridomas
Investigators:
Adriano Aguzzi, Paolo Dametto, Simone Hornemann (University Hospital of Zürich, Switzerland)
4
Selected Projects
CJD-diagnostic
Detection of PrPTSE surface-bound aggregates by Fluorescence Intensity Distribution Analysis
Investigator:
Dr. Eva Birkmann (Heinrich-Heine-University Düsseldorf, Germany )
5
Selected Projects
SMAD-Prion
Statistical methodology for assessing prion decontamination procedures
Investigator:
Pierre-Yves Boëlle (Paris VI University, France)
6
Selected Projects
RAP-Experimental Treatment
Experimental treatment of TSE-infected cell cultures and sCJD-infected HuTg mice with RAP, a protein folding chaperone
Investigators:
Dr Larisa Cervenakova, Elena Semenova, Oksana Yakovleva, Carroll McKenzie(American Red Cross, Rockville, USA)
7
Selected Projects
CSF Real-time QuiC
Development and evaluation of a diagnostic test for sporadic and variant CJD based on detection of PrPTSE in the cerebrospinal fluid using real-time QuiC analysis
Investigators:
Dr Alison Green, Dr Lynne McGuire, Dr Mark Head, Pr Robert Will, Pr Richard Knight (NCJDSU, Edinburgh, UK)
8
Selected Projects
Sheep BSE
In vitro model of risk to humans if the molecular signature of BSE in sheep during serial PMCA becomes indistinguishable from scrapie’ but retains its human pathogenicity
Investigators:
Dr Mark Head, (NCJDSU, Edinburgh,UK)Dr Lorenzo González, (VLA Lasswade, UK)
Dr Michael Jones, (SNBTS, UK)
9
Selected Projects
Surf-PMCA
Use of contaminated metal wires as PMCA templates for the evaluation of prion decontamination procedures.
Investigators:
Pr Sylvain Lehmann, Dr Carole Crozet (CNRS Montpellier, France) Dr Joliette Coste, Dr Daisy Bougard (EFS PM, France), Dr Hubert Laude, Vincent Béringue (INRA, Jouy-en-Josas, France)
10
Selected Projects
TransGlutam
Transglutaminase – a facilitating enzyme common to the protein misfolding family?
Investigators:
Dr Cindy S. Orser, (iPDx Biosciences, Boulder, USA)
Pr Herbert Budka (Medical University, Vienna, Austria)
11
Selected Projects
PrPdetection
Detection of prions in biological fluids and tissues using Thienyl Pyrimidine compounds (enhanced PK resistance of PrPTSE)
Investigator:
Dr Véronique PERRIER ( INSERM, Montpellier University, France)
12
Selected Projects
Nanoparticle prion capture
Magnetic nanoparticle capture/removal of PrPTSE from blood followed by PMCA detection
Investigators:
Surachai Supattapone, Michael Miller (Dartmouth Medical School, USA)