formula parasetamol

8/12/2019 Formula Parasetamol

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Evaluation of tapioca sago starch as a binder in tablet formulation

Upendra Kulkarni , Basawaraj S.Patil, Prakash G. Korwar*

Department of Pharmaceutics, R.M.E.S Collee of Pharmac!, Gul"ara

*Corresponding Author: #pen$ra Kulkarni Email address : upen$ra%&'(mail.com

,)',*+ )R#-D R/ 'KD#PD0R1-R+2 D-G 34#ED 0R#PD56R-+Visit

wwwi!pi!ournalscom

Abstract

+arious plant ums like elatin, acacia, alinic aci$, uar um, mai7e starch, an$ potato starch. ha8e

"een use$ as "in$er in pharmaceutical formulations. But still fin$in no8el "in$er is useful in the

pharmaceutical in$ustr! for manufacture of ta"lets. 9he 9apioca sao starch was foun$ for its "in$in

propert!. 9apioca sao starch has "een e8aluate$ for rele8ant properties an$ use$ as a "in$er to Paracetamol

ta"lets at concentrations of :.;, &;.; an$ &8. 9he ranules were e8aluate$ for moisture content, anle

R/ #4SR+4? E@ G4-+652 D-G 5DSS4G G4-+652? 0D##*+ 0RPS#4++6E6652 6-G4A D-G KD+-#D56R? K4 5DE45+ 4#4e8aluate$ for thickness, weiht 8ariation, crushin strenth, fria"ilit!, $isinteration time an$ $issolution

profiles. Paracetamol ta"lets containin elatin as stan$ar$ "in$er were pro$uce$ an$ assesse$ comparati8el!.

Results o"taine$ in$icate$ that 9apioca sao starch performe$ as oo$ as elatin as a "in$er to Paracetamol

ta"lets.

Ke" words: 9apioca sao starch, Paracetamol, Gelatin, Bin$er, 9a"lets.


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Upendra Kulkarni et al

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Bin$ers are aents use$ to impart cohesi8e ualities to the pow$ere$ material $urin the pro$uction of ta"lets.

9he! impart cohesi8eness to the ta"let formulation, which ensures that the ta"lets remain intact after compression as

well as impro8in the free flowin ualit!. Bin$ers ha8e "een use$ as solutions in the formulations an$ the metho$ of&

preparation. 9he choice of a particular "in$in aent $epen$s on the "in$in force reuire$ to form ranules an$ its

compati"ilit! with the other inre$ients particularl! the acti8e $ru.r)&

Bulk and Tapped Densities:

Eactl! F; m of ranules was weihe$ on chemical "alance an$ transferre$ into a &;; ml measurin c!lin$er.

9he c!lin$er was $roppe$ on a woo$en platform from a heiht of


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age 9D

4R 9D>BD

reparation of 5ablets

Manesium stearate, talc an$ aerosol 5 J &;;

Disintegration Test:

9he $isinteration time of ta"lets was $etermine$ accor$in to the metho$ $escri"e$ in the British

Pharmacopoeia &II:. Si ta"lets were place$ in each compartment of the $isinteration apparatus, with water

thermostate$ at ' & C as the me$ium. 9he ta"lets were consi$ere$ to ha8e passe$ the test after the % ta"lets passe$;

throuh the mesh of the apparatus in &F minutes.


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Calibration Cur#e for Paraetamol:

stock solution of Paracetamol was prepare$ "! $issol8in &;; m of the $ru in &;; ml of ;.& 4Cl. +arious

$ilutions of the stock were ma$e so as to o"tain ;.;&, ;.;$m . 9he col$ water solu"ilit! of starches is relate$ to their am!lase>am!lopectin'

constituents. 9he hiher the water solu"le am!lopectin constituent, the hiher the col$ water solu"ilit! of the can$i$ate

starch while the hiher the col$ water insolu"le am!lase, the re8erse "ecomes the case. 9he low "ulk an$ tappe$

$ensities of "oth 9apioca sao starch an$ elatin pow$ers in$icate that "oth materials were not hihl! porous an$ are

poor flowin pow$ers. 9he low "ulk $ensit! results when the 8oi$ spaces create$ "! larer pow$er particles were not

fille$ "! smaller particles in $istri"ution lea$in to consoli$ation of pow$er particles. & 9he confirmation of the non

free flowin nature of DS6R0D +D1R +5D#0K D-G 14D56- SRG4#+ 4#4 1R554- /#RP 5K4 /D05 53D+-4#*+ #D56R R/&.''I an$ &.;&& respecti8el! an$ these were reater than &.< which in$icate low inter particulate friction pow$er. &F

we8er, 9apioca sao starch SR++4++4G E4554# /R S#RS4#564+ 5KD- 14D56- D+ 0R-/6#P4G E2 LDS#4++6E6652in$e of


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Table %: Pre&ompression Parameters Data for Paraetamol $ranules

arameters 3ormulation Code

5# ;# 5% ;% 59 ;9

Bulk $ensit! Hm>mlJ ;.F;F ;.F&' ;.F


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in$ication that lower concentration of 9apioca sao starch than elatin coul$ "e use$ to achie8e the same le8el of

"in$in. 9he fria"ilit! of all the formulations "elow &.;=. 9he weiht 8ariation of all the formulations were within the

rane of %;&)%; m. Disinteration time of all the formulations are within the official limits of B.P. H&II:J.

9he ta"let thickness of all the formulations were similar an$ this can "e attri"ute$ to their similar "ulk an$

tappe$ $ensities an$ same compressional force use$. 9he $iameter of all the ta"lets were same i.e. &D9 8alues increase$ with increasin "in$er concentration H9a"le J.

ACK417E0;E6E45

he authors are thankful to Prof. Ki+KR#4+6-1K .?L? '#4+6G4-5? F?;?H?%*+ LR414 R/ 'KD#PD02 QED#1

his 8alua"le support an$ pro8i$in necessar! facilities to carr! out the research work.

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&. . 6-1 FH? DE45+ 6- F4P6-15R-*+ 'KD#PD04560D %064-04+? ??th E$. Mack Pu". Co!. Easton, Pennns!l8ania,

&IF, &F:.


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formula parasetamol

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