fluid and electrolyte emergencies in critically ill children
TRANSCRIPT
![Page 1: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/1.jpg)
Fluid and Electrolyte Emergencies in Critically
Ill Children
Fluid and Electrolyte Emergencies in Critically
Ill Children
Richard T. Blaszak, M.D. Stephen M. Schexnayder, M.D.
![Page 2: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/2.jpg)
ObjectivesObjectives
At the end of this presentation learners will be able to:
• 1) Recognize common fluid and electrolyte disorders in critically ill children
• 2) List a diagnostic strategy for these disorders
• 3) Apply appropriate management principles
![Page 3: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/3.jpg)
Case Study #1
• HPI:• A 3 month-old is in the PICU for shock following a two day
history of fever and irritability. Blood and CSF cultures are positive for Streptococcus pneumoniae.
• Hospital course: • Decreasing urine output (< 0.5 ml/kg/hr) over the last 24
hours.
![Page 4: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/4.jpg)
Case Study #1Case Study #1
What is your differential diagnosis?
What diagnostic studies would you order?
![Page 5: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/5.jpg)
Case Study #1
Differential diagnosisCase Study #1
Differential diagnosis
Oliguria
1) Pre-Renal (decreased effective renal blood flow)Diminished intravascular volume, cardiac dysfunction,
vasodilitation
2) Post-RenalOutlet obstruction (intrinsic vs. extrinsic), foley catheter occlusion
3) RenalAcute tubular necrosis, acute renal failure, SIADH, ...
![Page 6: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/6.jpg)
Case Study #1
Laboratory studies
Serum studiesSodium 126 mEq/L BUN 4 mg/dLChloride 98 mEq/L Creatinine 0.4 mg/dLPotassium 3.7 mEq/L Glucose 129 mg/dLBicarbonate 25 mEq/L Osmolality 260 mosmol/kg
Urine studiesSpecific gravity 1.025 Sodium 58 mEq/LOsmolality 645 mosmol/kg FeNa 2.4%
What are the primary abnormalities?
![Page 7: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/7.jpg)
Case Study #1
Laboratory studies
Major abnormalities
1) Hyponatremia
2) Oliguria (inappropriately concentrated urine)
What is the most likely explanation for these findings?
![Page 8: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/8.jpg)
Case Study #1 Syndrome of Inappropriate Antidiuretic
Hormone (SIADH)
• Variable etiology• Trauma• Infection• Psychosis• Malignancy• Medications• Diabetic ketoacidosis• CNS disorders• Positive pressure ventilation• “Stress”
![Page 9: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/9.jpg)
Case Study #1 SIADH
Case Study #1 SIADH
• Manifestations• By definition, “inappropriate” implies having excluded
normal physiologic reasons for release of ADH:• 1) In response to hypertonicity.• 2) In response to life threatening hypotension.
• Hyponatremia• Oliguria• Concentrated urine
• elevated urine specific gravity• “inappropriately” high urine osmolality in face of hyponatremia
• Normal to high urine sodium excretion
![Page 10: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/10.jpg)
Case Study #1 SIADH
Case Study #1 SIADH
• Diagnosis• Critical level of suspicion.• Demonstration of inappropriately concentrated urine in
face of hyponatremia urine osmolality, SG, urine sodium excretion ( FeNa)
• Be certain to exclude normal physiologic release of ADH Frequently secondary to decreased perfusion Serum sodium, urine osmolality, urine sodium
excretion (low FeNa) consistent with dehydration or diminished renal blood flow. Look at patient more closely !!
![Page 11: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/11.jpg)
Case Study #1 SIADH
• Treatment
• Fluid restriction.• 50-75% of maintenance requirements, be certain to
include oral intake.
• Daily weights.
![Page 12: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/12.jpg)
Case Study #1
The saga continues….
Hospital course:Four hours after beginning fluid restriction, you are called
because the patient is having a generalized seizure. There is no response to two doses of IV lorazepam (Ativan®) and a loading dose of fosphenytoin (Cerebyx®)
What is the most likely explanation?
![Page 13: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/13.jpg)
Case Study #1
The saga continues
Seizure
1) Worsening hyponatremia2) Intracranial event3) Meningitis4) Other electrolyte disturbance5) Medication6) Hypertension
What diagnostic studies would you order?
![Page 14: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/14.jpg)
Case Study #1
The saga continues
Stat labs:Sodium 117 mEq/L
What would you do now?
![Page 15: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/15.jpg)
Case Study #1 Hyponatremic seizure
• Treatment • Hypertonic saline (3% NaCl) infusion
• To correct sodium to 125 mEq/L, the deficit is equal to (0.6)(weight[kg])(125- measured sodium) (0.6)(8)(125-117) = 38.4 mEq
• Because patient is symptomatic with seizures, immediately increase serum sodium by 5 mEq/L
mEq sodium = (0.6)(8 kg)(5) = 24 mEq
• 3% NaCl = 0.5 mEq/L, therefore 24 mEq bolus = 48 mls, followed by slow infusion of remaining 14.4 mEq (29 mls) over next several hours
![Page 16: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/16.jpg)
Case Study #2
HPI:A 5 month-old girl presents with a one day history of irritability
and fever. Mother reports three days of “bad” vomiting and diarrhea.
Home meds:Acetaminophen and ibuprofen for fever
PE: BP 70/40, HR 200, R 60, T38.3 C. Irritable, sunken eyes and
fontanelle, skin feels like Pillsbury Dough Boy
![Page 17: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/17.jpg)
Case Study #2Case Study #2
No one can obtain IV access after 15 minutes, what would you do now?
![Page 18: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/18.jpg)
Case Study #2
Place intraosseous lineBolus 40 ml/kg of isotonic salineReassessment (HR 170, RR 40, BP 75/40)
Serum studiesSodium 164 mEq/L BUN 75 mg/dLChloride 139 mEq/L Creatinine 3.1 mg/dLPotassium 5.5 mEq/L Glucose 101 mg/dLBicarbonate 12 mEq/LpH 7.07 pCO2 11
pO2 121 HCO3 8
![Page 19: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/19.jpg)
Case Study #2Case Study #2
What is the most likely explanation of this patients acidosis?
![Page 20: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/20.jpg)
Case Study #2
Metabolic acidosis and the anion gap
Case Study #2
Metabolic acidosis and the anion gap
Anion GapSodium - (chloride + bicarbonate)
Normal 12 +/- 2 meq/L
Elevated anion gap consistent with excess acidNormal anion gap consistent with excess loss of base
164 - (139 + 12) = 13
![Page 21: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/21.jpg)
1. Normal gap 2. Increased gap
1. Renal “HCO3” losses
2. GI “HCO3” losses
Proximal RTA Distal RTA Diarrhea
1. Acid prod 2. Acid elimination
LactateDKAKetosisToxins Alcohols Salicylates Iron
Renal disease
Case Study #2
Metabolic acidosis and the anion gap
Case Study #2
Metabolic acidosis and the anion gap
![Page 22: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/22.jpg)
Case Study #3
• HPI:• A five year old (18 kg) boy was involved in a a motor vehicle
accident two days ago. He sustained an isolated head injury with intraventricular hemorrhage and multiple large cerebral contusions. Three hours ago, he had an episode of severe intracranial hypertension (ICP 90mm Hg, MAP 50mm Hg, requiring volume plus epinephrine infusion for hypotension. Over the last two hours, his urine output has increased to 130-150 ml/hour (~8ml/kg/hr).
What is your differential diagnosis?What test would you order?
![Page 23: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/23.jpg)
Case Study #3
Differential diagnosisCase Study #3
Differential diagnosisPolyuria
1) Central diabetes insipidusDeficient ADH secretion (idiopathic, trauma, pituitary surgery,
hypoxic ischemic encephalopathy)
2) Nephrogenic diabetes insipidusRenal resistance to ADH (X-linked hereditary, chronic lithium,
hypercalcemia, ...)
3) Primary polydipsia (psychogenic)Primary increase in water intake (psychiatric), occasionally
hypothalamic lesion affecting thirst center
4) Solute diuresisDiuretics (lasix, mannitol,..), glucosuria, high protein diets, post-
obstructive uropathy, resolving ATN, ….
![Page 24: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/24.jpg)
Case Study #3
Laboratory studies
Serum studiesSodium 155 mEq/L BUN 13 mg/dLChloride 114 mEq/L Creatinine 0.6 mg/dLPotassium 4.2 mEq/L Glucose 86 mg/dLBicarbonate 22 mEq/L Serum osmolality: 320 mosmol/kg
OtherUrine specific gravity 1.005, no glucose.Urine osmolality: 160 mosmol/kg
What are the main abnormalities?
![Page 25: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/25.jpg)
Case Study #3
Laboratory studies
Major abnormalities
1) Hypernatremia2) Polyuria (inappropriately dilute urine)
What is the most likely explanation?
![Page 26: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/26.jpg)
Case Study #3
Diabetes Insipidus
DiagnosisCentral Diabetes insipidus
1) Polyuria2) Inappropriately dilute urine (urine osmolality < serum
osmolality)
May be see with midline defectsFrequently occurs in brain dead patients
What should you do to treat this child?
![Page 27: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/27.jpg)
Case Study #3
Diabetes Insipidus
• Treatment • Acute: Vasopressin infusion - begin with 0.5
milliunits/kg/hour, double every 15-30 minutes until urine flow controlled
• Chronic: DDAVP (desmopressin)
• Warning• Closely monitor for development of hyponatremia
![Page 28: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/28.jpg)
Case Study #4
HPI:A six year old, 25 kg, boy with severe asthma (S/P ECMO for a
previous exacerbation) presents with a two day history of severe vomiting and diarrhea to the Emergency Department.
Home meds:Albuterol MDI two puffs QID, Salmeterol MDI two puffs BID,
Prednisone 10mg daily, Fluticasone 220 mcg two puffs BID
PE: BP 70/40, HR 168, R 40, T39.0 C. He is very lethargic (GCS 11).
Poor perfusion with cool extremities, mottling, and delayed capillary refill, otherwise no specific system abnormalities.
![Page 29: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/29.jpg)
Case Study #4Case Study #4
What is your differential diagnosis?
What diagnostic studies would you order?
![Page 30: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/30.jpg)
Case Study #4
Differential diagnosisCase Study #4
Differential diagnosis
Shock1) Cardiogenic
MyocarditisPericardial effusion
2) HypovolemicHemorrhage, excessive GI losses, “3rd spacing” (burns, sepsis)
3) DistributiveSepsis, anaphylaxis
![Page 31: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/31.jpg)
Case Study #4
Laboratory studies
Serum studiesSodium 130 mEq/L BUN 43 mg/dLChloride 99 mEq/L Creatinine 0.6 mg/dLPotassium 5.7 mEq/L Glucose 48 mg/dLBicarbonate 12 mEq/L
OtherWBC: 13k (60% P, 30% L), HCT 35%, PLT 223kChest radiograph: no abnormalities
What are the electrolyte abnormalities?
![Page 32: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/32.jpg)
Case Study #4
Diagnosis
Major abnormalities
1) Hyponatremic dehydration
2) Hypoglycemia3) Hyperkalemia, mild4) Acidosis5) Azotemia
What is the most likely explanation for these findings?
![Page 33: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/33.jpg)
Case Study #4 Adrenal Insufficiency
• 1o adrenal insufficiency (Addison’s disease)• Adrenal gland destruction/dysfunction (ie. autoimmune,
hemorrhagic)• most common in infants 5-15 days old
• 2nd adrenal insufficiency • ACTH deficiency (ie. panhypopituitarism or isolated ACTH)
• “Tertiary” or “iatrogenic” • Suppression of hypothalamic-pituitary-adrenal axis (ie.
chronic steroid use)
![Page 34: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/34.jpg)
Case Study #4 Adrenal Insufficiency
Case Study #4 Adrenal Insufficiency
• Manifestations• Major hormonal factor precipitating crisis is mineralcorticoid
deficiency, not glucocorticoid.
• Dehydration, hypotension, shock out of proportion to severity of illness
• Nausea, vomiting, abdominal pain, weakness, tiredness, fatigue, anorexia
• Unexplained fever• Hypoglycemia (more common in children and tertiary)• Hyponatremia, hyperkalemia, azotemia
![Page 35: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/35.jpg)
Case Study #4 Adrenal Insufficiency
Case Study #4 Adrenal Insufficiency
• Diagnosis• Critical level of suspicion in all patients with shock
• 1) Demonstration of inappropriately low cortisol secretion• Basal morning level vs. random “stress” level
• 2) Determine whether cortisol deficiency dependent or independent of ACTH secretion.
• ACTH, cortisol 1o adrenal insufficiency • ACTH, cortisol 2nd or tertiary insufficiency
• 3) Seek a treatable cause
![Page 36: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/36.jpg)
Case Study #4 Adrenal Insufficiency
• What should you do to treat this child?
![Page 37: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/37.jpg)
Case Study #4 Adrenal Insufficiency
• Treatment• Do not wait for confirmatory labs
• Fluid resuscitation - isotonic crystalloid
• Treat hypoglycemia
• Glucocorticoid replacement - hydrocortisone in stress doses - 25-50 mg/m2 (1-2 mg/kg) IV
• Consider mineralocorticoid (Florinef®)
![Page 38: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/38.jpg)
Case Study #5
• HPI:• An eight month old infant with autosomal recessive
polycystic kidney disease presents with irritability. She is on nightly peritoneal dialysis at home. The lab calls a panic potassium value of 7.1 meq/L. The tech says it is not hemolyzed.
What do you do now?
![Page 39: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/39.jpg)
Case Study #5
Hyperkalemia
• Treatment
• Immediately repeat serum potassium. Do not wait for confirmatory labs especially if EKG changes
present.
• Anticipatory Stop potassium administration including feeds
![Page 40: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/40.jpg)
Cardiac MonitorCardiac Monitor
• What is this rhythm?• What is your immediate treatment?
![Page 41: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/41.jpg)
Case Study #5
Hyperkalemia• Treatment (cont)• Control effects
• Antagonism of membrane actions of potassium Calcium chloride 10-20 mg/kg over 5 minutes; may repeat
x2
• Shift potassium intracellularly Glucose 1 gm/kg plus 0.1 unit/kg regular insulin Alkalinize (increase ventilator rate; Sodium bicarbonate 1 mEq/kg
IV) Inhaled 2 adrenergic agonist (albuterol)
• Removal of potassium from the body Loop / thiazide diuretics Cation exchange resin: sodium polstyrene sulfonate
(Kayexelate®) 1 gm/kg PO or PR (or both) Dialysis
![Page 42: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/42.jpg)
Case Study #6
• HPI:• A three year old boy is recovering from septic shock. He
received 150 ml/kg in fluid boluses in the first 24 hours and has anasarca. You begin him on a bumetanide infusion (Bumex®) for diuresis. He develops severe weakness and begins to hypoventilate. You notice unifocal premature ventricular beats on his cardiac monitor.
What is your differential diagnosis?What tests would you order?
![Page 43: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/43.jpg)
Case Study #6
Laboratory studies
Serum studiesSodium 134 mEq/L BUN 11 mg/dLChloride 98 mEq/L Creatinine 0.4 mg/dLPotassium 2.4 mEq/L Calcium 9.2 mg/dLBicarbonate 27 mEq/L Phosphorus 3.2 mg/dL
OtherEKG: Unifocal PVC’s
What is the main abnormality?
![Page 44: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/44.jpg)
Case Study #6
Laboratory studies
Major abnormality
1) Hypokalemia
What would you do now?
![Page 45: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/45.jpg)
Case Study #6
Hypokalemia
• Treatment
• Oral • Safest, although solutions may cause diarrhea
• IV• Peripheral: do not exceed 40-50 mEq/L potassium - Avoid Avoid
temptation to rapidly bolustemptation to rapidly bolus• Central: 0.5 -1 mEq/kg over 1-3 hours, depending on severity
• Replace magnesium also if low• (25-50 mg/kg MgSO4)
![Page 46: Fluid And Electrolyte Emergencies In Critically Ill Children](https://reader035.vdocuments.us/reader035/viewer/2022062404/554b5a3db4c905e9388b4f58/html5/thumbnails/46.jpg)
Summary
• Disorders of sodium, water, and potassium regulation are common in critically ill children
• Diagnostic approach must be considered carefully for each patient
• Strict attention to detail is important in providing safe and effective therapy