Ingredients: Dextrose, Inulin, Dipotassium phosphate, Sodium ascorbate, Citric acid, Sodium aluminosilicate, dry Pedioccocus acidilactici fermentation product, dry Weissella confusa fermentation product.

Contains a source of live (viable) naturally occurring microorganisms for use in poultry.

Total guaranteed minimum count: 15,000,000 CFU/g (Pediococcus acidilactici, Weissella confusa)

Directions for Use: Discontinue the use of disinfectants, antibiotics, or other additives that may kill the microflora for 24 hours before and 24 hours after use of the product in the drinking water.

Providing birds with acidified water prior to use of FloraMax-PW will enhance delivery of beneficial microflora.

Mix one bottle (140g) in enough stock solution to provide to 20,000 birds. Add the stock solution to the drinking water at a rate of 1 oz. per gallon over a period of 6-12 hours.

Storage: Packaging: Order code:

Keep refrigerated. 140 grams for 20,000 birds 154774

Manufactured by Novozymes Biologicals Inc.2135 Creek View, Fayetteville, Arkansas 72704FloraMax®-PW is a registered trademark of Novozymes A/S.

Distributed by Boehringer Ingelheim Animal Health USA Inc.3239 Satellite Blvd., Duluth, Georgia 30096

POU-0033-POUL1118

When to apply:As early as possible to establish a healthy and protective microbial population in the intestinal tract, before and in stress occasions, at specific points in the growing timeline due to increased risk of susceptibility colonization, to reduce dysbacteriosis, and 2 weeks prior to slaughter.• DOA placement• Feed or ingredient changes• Enteric disease challenge• Feed withdrawal• Transfers

FloraMax-PW helps protects the GIT

©2019 Boehringer Ingelheim Animal Health USA Inc.

Visit us at

poultryhealthusa.com

References1 Food and Agriculture Organization of the United Nations. Probiotics in Animal

Nutrition, Production, Impact and Regulation. 2016. Rome.Page 15-31. 2 Novozymes internal data.3 Omar F. Prado-Rebolledo, Jaime de Jesus Delgado-Machuca, Rafael J.

Macedo-Barragan, Luis J. Garcia-Marquez, Jesus E. Morales-Barrera, Juan D. Latorre, Xochitl Hernandez-Velasco & Guillermo Tellez (2017) Evaluation of a selected lactic acid bacteria-based probiotic on Salmonella enterica serovar Enteritidis colonization and intestinal permeability in broiler chickens, Avian Pathology, 46:1, 90-94.

4 Borda-Molina Daniel; Seifert Jana; Camarinha-Silva Amélia. Current Perspectives of the Chicken Gastrointestinal Tract and Its Microbiome, Institute of Animal Science. 2018. University of Hohnenheim, Stuttgart, Germany

5 Kers, Jannigje G.;1,2* Velkers Francisca C.;¹ Fischer Egil A. J.; Hermes Gerben D. A.² ; Stegeman J. A.;1 Hauke Smidt2. Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens.1 2018. Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands;² Laboratory of Microbiology, Wageningen University & Research, Wageningen,Netherlands.

6 Stanley, Dragana; Huges Robert J.; Moore Robert J. Microbiota of the chicken gastrointestinal tract: influence on health, productivity and disease. 2014.

7 Biloni et al, Poultry Science. 2013. 92 :2337–2346. 8 Haghighi et al. Probiotics Stimulate Production of Natural Antibodies in

Chickens. 2006. Clinical and Vaccine Immunology, 13:9, 975-980. 9 Adapted from https://www.poultryworld.net/Health/Articles/2018/10/Keep-

gut-health-challenges-at-bay-351899E

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CONTAINS NO ANIMALPRODUCTS

ALL NATURAL

Contains No Products

of Animal Origin

CONTAINS NO PRODUCTS OF ANIMAL ORIGIN

ALL NATURAL

CONTAINS NO ANIMAL

NATURAL

Contains No Ingredients of Animal

OriginCONTAINS NO PRODUCTS

OF ANIMAL ORIGIN

ALL NATURAL

1a2a

CONTAINS NO ANIMALPRODUCTS

ALL NATURAL

Contains No Products

of Animal Origin

CONTAINS NO PRODUCTS OF ANIMAL ORIGIN

ALL NATURAL

3a

Improving Gut Health is an Essential Component of Pathogen Control Salmonella is more than a processing plant issue - it originates from a live production source.Salmonella control programs are multifaceted and complex. However, one of the more essential components of an effective Salmonella control program is maintaining a healthy intestinal tract.

Improving the intestinal health of birds enhances poultry performance.1,2 FloraMax-PW is a unique combination of live microorganisms, Pediococcus acidilactici and Weissella confusa. Studies have shown that these bacteria bind to mucin and intestinal epithelial cells thereby competing with pathogens for space in the gut. These bacteria have been shown to increase transepithelial electrical resistance which improves barrier function in the gut. They produce metabolites which positively alter the intestinal environment. In experimental conditions, Pediococcus acidilactici and Weissella confusa have improved the management of Salmonella.

Start Your Gut Health Program Early

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FloraMax®-PWFloraMax-PW is a probiotic developed to support the enteric health of the bird. The two strains, Pediococcus acidilactici and Weissella confusa may make the birds less susceptible to Salmonella.3 Containing no ingredients of animal origin, the product has shown to establish a highly protective microflora within the gastrointestinal tract.

Both strains were selected for their unique ability to secure gut health through colonization in the gut leading to a barrier effect, growth inhibition of certain pathogens, and reinforcement of the GIT tight junction.

ProbioticsUsing probiotics has shown to increase the average daily weight gain, improve food conversion ratio, and improve food safety from bacterial pathogens.1 These factors have a positive impact on the poultry industry while providing safe and healthy poultry for human consumption by reducing the pathogen load of Salmonella.

How do probiotics work in chickens?Colonization of the gastrointestinal tract (GIT)

1. Lactic acid bacteria are among the first microorganisms to colonize the gastrointestinal tract of a newly hatched chick.4

2. Lactobacillus sp. dominate the upper gastrointestinal tract of chickens, including the crop, the gizzard, and the duodenum.5, 6

Crop

Gizzard

Duodenum

Ceca

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Mode of Action

How does Pediococcus acidilactici (P) andWeissella confusa (W) improve bird intestinal health?

P and W impact the microbiome composition2

P and W adhere to both mucus and epithelium2

P produces Lactate, W produces Acetate and Ethanol2

Probiotics

Antimicrobial substances

Pathogenic bacteria

Enterocytes

Lymphocyte

Antibodies

Modulate microbial ecosystem which increase diversity, inhibit taxon overgrowth, and favor beneficial taxa

Production of antimicrobial substances that inhibit microorganisms or prevent their reproduction2

Competition for binding sites: Probiotics occupy these so that pathogenic microorganisms cannot adhere to them

Production of lactic acid, which inhibits the growth of microorganisms and stabilizes gut flora

0 1

3

W increases tight junction2

Improvement of barriers: intercellular junctions are more tightly sealed

4

2

Lactic acid

P and W increase the height of epithelium vilosity7

Improvement of barriers: epithelium repair is accelerated

4

Probiotics stimulate the immune response leading to increased formation of antibodies8

5

FloraMax-PW is a unique combination of live organisms:

P : Pediococcus acidilacticiW : Weissella confusa

Schematic representation of the most important mechanisms of action of probiotic.9*

Antimicrobial substancesLymphocytes Enterocytes

Antibodies

Probiotics

Pathogenic Bacteria Lactic Acid

*Photo: Evonik

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