DEFINATION: Epilepsy is a disorder in which there is a

tendency for the occurance of epileptic seizures.

CAUSES: 1.Ideopathic: Cause unknown 2.Symptomatic:

      Trauma, metabolic disorders

Partial Seizures   1. Simple     2. Complex

Generalized seizures 1.Tonic-clonic 2. MyoclonicGeneralized epilepsy

  1. Benign neonatal convulsion   2. Childhood absence  

DRUGS USED IN EPILEPSY: BARBITURATES:

        1. PHENOBARBITAL VALPROIC ACID OTHER AGENTS

 A. FELBATOL (FELBAMATE)  B. NEURONTIN (GABAPENTIN)

FLOATING TABLETS: EFFERVACENT NONEFFERVACENT

Oral route is the most preferred route of drug administration.Good patient compliance.Most of the drugs exhibit site specific absorption in GITFloating drug delivery system is one of the very good approach for controlled release of the drug

MATERIALS:

GABAPENTEIN HPMC GUARGUM Na BICARBONATE TARTARIC ACID Mg STERATE TALC NINHYDRIN

EQUIPMENTS

ELECTRONIC BALANCE

PUNCHING MACHINE

HARDNESS TESTER VERNIER CALIPERS DISSOLUTION

APPARATUS

EXPERIMENTAL:  DRUG (GABAPENTEIN)

MIXED IN BLENDOR

PREPARATION OF GRANULES

PASSED THROUGH SIEVE NO 18

DRIED IN PROCESSOR

GRANULES ARE COMPRESSED TO TABLETS

EVALUATION OF TABLETS

Floating lag timeDuration of floatingDimensional stabilityWater uptake studyIn vitro dissolutionRelease kinetics: Zero – order release kinetics: First– order release kinetics: Higuchi (Diffusion) equation: Q = k2t1/2