Your single-source laboratory solution.

FISH Probe Library

Probe Clinical Indication

1p36 (TP73)/19q13 (GLTSCR) Follicular lymphoma, Oligodendroglioma

1q21 (CKS1B) Plasma cell neoplasm*

5q (CSF1R/RPS14) AML, MDS

7q (MDFIC) AML, MDS, MPN

13q14 (DLEU) Plasma cell neoplasm*, CLL, MDS, MPN

20q (PTPRT) MDS, MPN

21q B-ALL (adult), AML

ALK NSCLC, T-cell anaplastic lymphoma

ATM CLL

BCL2 Follicular lymphoma, Large B-cell lymphoma

BCL6 Follicular lymphoma, Large B-cell lymphoma

BCR/ABL1, t(9;22) B-ALL (adult and pediatric), AML, CML

CBFB, inv(16) AML

CCND1 (CYCLIN D1) CLL, Mantle cell lymphoma, Plasma cell neoplasm*

CCND1/IgH, t(11;14) CLL, Mantle cell lymphoma, Plasma cell neoplasm*

CDKN2A (p16) (9p21) B-ALL (pediatric)

CKS1B (1p/1q ) Plasma cell neoplasm*

Centromere 4 Enumeration Probe B-ALL (pediatric)

Centromere 6 Enumeration Probe B-ALL (adult), Melanoma

Centromere 7 Enumeration Probe Plasma cell neoplasm*

Centromere 8 Enumeration Probe MDS, MPD, MPN

Centromere 9 Enumeration Probe MPN, Plasma cell neoplasm*

Centromere 10 Enumeration Probe B-ALL (pediatric)

Centromere 12 Enumeration Probe CLL

Centromere 15 Enumeration Probe Plasma cell neoplasm*

Centromere 17 Enumeration Probe B-ALL (pediatric)

DDIT3 (CHOP) Myxoid/Round cell liposarcoma

EGFR Glioma, NSCLC

ETV6/RUNX1 (TEL/AML), t(12;21) B-ALL, iAMP ALL

EWSR1 Ewing sarcoma, PNET

FGFR1 MPN with eosinophilia

Alphabetical List by Probe with Clinical Indication

1

Probe Clinical Indication

*includes Multiple myeloma and MGUS

FGFR3/IGH, t(4;14) Plasma cell neoplasm*

FOXO1 (FKHR) Alveolar rhabdomyosarcoma

HER2 Breast, Gastric cancer

IGH B-cell lymphoma

IGH/BCL2, t(14;18) Follicular lymphoma, Large B-cell lymphoma

IGH/MAF, t(14;16) Plasma cell neoplasm*

IGH/MYC, t(8;14) Burkitt lymphoma, High grade B-cell lymphoma

KMT2A (MLL) B-ALL (adult and pediatric), AML

MALT1, t(11;18) Marginal zone lymphoma

MECOM (EVI1) AML, MDS

MET NSCLC

MYB Melanoma

MYC Burkitt lymphoma, High grade B-cell lymphoma

MYCN Neuroblastoma

PDGFRA MPN with eosinophilia

PDGFRB MPN with eosinophilia

PML/RARA, t(15;17) APL

PTEN Glioma

RARA APL

RB1 (13q14) Retinoblastoma

RET NSCLC

ROS1 NSCLC

RREB1 Melanoma

RUNX1T1/RUNX1 (ETO/AML), t(8;21) AML

SS18 (SYT) Synovial sarcoma

TCF3 (E2A) B-ALL (pediatric)

TCR T-cell leukemia

TP53 (17p deletion) AML, CLL, MDS, Plasma cell neoplasm*

UroVysion® Bladder cancer

XX/XY Bone marrow transplant

2

Disease Probes Included

3

B-ALL (Adult)

21qBCR/ABL1, t(9;22)Chromosome 6 KMT2A (MLL)MYC

B-ALL (Pediatric)

BCR/ABL1, t(9;22)CDKN2A (p16) Centromere 4Centromere 10Centromere 17ETV6/RUNX1, t(12;21) KMT2A (MLL)TCF3 (E2A)

AML

5q 7q CBFB, inv(16)KMT2A (MLL) PML/RARA, t(15;17) RUNX1T1/RUNX1, t(8;21)

CLL

13q14 (DLEU) ATM (11q)CCND1/IGH, t(11;14)**Centromere 12TP53 (17p)

MDS

5q7q20qCentromere 8

MPN/CML

13q14 (DLEU) 20qBCR/ABL1, t(9;22) CDKN2A (Centromere 9) Centromere 8

MPN with EosinophiliaFGFR1PDGFRAPDGFRB

Multiple Myeloma

13q14 (DLEU)CCND1/IGH, t(11;14)Centromere 7Centromere 9Centromere 15CKS1B (1q21)FGFR3/IGH, t(4;14)IGH/MAF, t(14;16)TP53 (17p)

Aggressive B-cell LymphomaBCL2BCL6MYC

Hematology/Oncology Profiles

**used as differential

Disease Probe

4

Solid Tumor Probes

Breast Cancer HER2

Bladder Cancer UroVysion®

Colorectal Cancer EGFR

Gastric Cancer HER2

Glioma1p/19qEGFRPTEN

Lung Cancer (Non-Small Cell)

ALKMETRETROS1

Melanoma

CCND1Centromere 6 MYBRREB1

Neuroblastoma MYCN

Retinoblastoma RB1 (13q14)

Sarcomas

Ewing Sarcoma EWSR1

Alveolar Rhabdomyosarcoma FOXO1 (FKHR)

Synovial Sarcoma SS18 (SYT)

Myxoid/Round Cell Liposarcoma DDIT3 (CHOP)

Probe Clinical Indication

5

Probes Suitable for FFPE† Specimens

1p36 (TP73)/19q13 (GLTSCR) Follicular lymphoma, Oligodendroglioma

ALK NSCLC, T-cell anaplastic lymphoma

BCL2 Follicular lymphoma, Large B-cell lymphoma

BCL6 Follicular lymphoma, Large B-cell lymphoma

BCR/ABL1, t(9;22) B-ALL (adult and pediatric), CML

CBFB, inv(16) AML

CCND1 (CYCLIN D1) CLL, Mantle cell lymphoma, Plasma cell neoplasm*

CCND1/IgH, t(11;14) CLL, Mantle cell lymphoma, Plasma cell neoplasm*

DDIT3 (CHOP) Myxoid/Round cell liposarcoma

EGFR Glioma, NSCLC

ETV6/RUNX1 (TEL/AML), t(12;21) B-ALL

EWSR1 Ewing sarcoma, PNET

FOXO1 (FKHR) Alveolar rhabdomyosarcoma

HER2 Breast, Gastric cancer

IGH B-cell lymphoma

IGH/BCL2, t(14;18) Follicular lymphoma

IGH/MYC, t(8;14) Burkitt lymphoma, High grade B-cell lymphoma

KMT2A (MLL) B-ALL (adult and pediatric), AML

MALT1, t(11;18) Marginal zone lymphoma

MET NSCLC

MYC Burkitt lymphoma, High grade B-cell lymphoma

MYCN Neuroblastoma

PDGFRA MPN with eosinophilia

PDGFRB MPN with eosinophilia

PTEN Glioma

RB1 (13q14) Retinoblastoma

RET NSCLC

ROS1 NSCLC

SS18 (SYT) Synovial sarcoma

TCR T-cell leukemia

XX/XY Bone marrow transplant

†Formalin-fixed, paraffin-embedded*includes Multiple myeloma and MGUS

6

Blood Optimal: 10 mL (adult) or 3-5 mL (pediatric) in green-top (heparin) tube

Acceptable: Lavender-top (EDTA) tube

Fixed-cell pellet from cytogenetic analysis

Slides prepared from a cytogenetic analysis

Bone Marrow Optimal: 1-3 mL in green-top (heparin) tube

Acceptable: Lavender-top (EDTA) tube

Fixed-cell pellet from cytogenetic analysis

Slides prepared from a cytogenetic analysis

Tissue Formalin-fixed, paraffin-embedded (FFPE) tissue block

4-5 unstained slides, cut to 4-5 microns thick, air-dried overnight

Specimens should be maintained at room temperature.

Type Preferred Alternate

For more specific specimen requirements for individual tests, please refer to

www.integratedoncology.com/test-menu.

Specimen Requirements

www.integratedoncology.com

UroVysion® is a registered trademark of Abbott Laboratories, Inc. ©2017 Laboratory Corporation of America® Holdings. All rights reserved.

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Menu of more than 450 genetic, pathology, IHC, and FISH tests, including 15 oncology-specific pharmacogenetic tests

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