50th Anniversary Landmark Study

OBJECTIVES

• Validate health benefits of Shaklee supplementation

• Compare Shaklee supplement users to other groups

• Confirm the safety of long term Shaklee supplement use

• First-of-its-Kind (Landmark) Study

• Collaboration with renowned nutritional epidemiologist

IMPORTANT HIGHLIGHTS

Dr. Gladys Block U.C. Berkeley

School of Public Health

• Proof of the Shaklee Difference

Another Multivitamin

Cross-sectional comparative analysis

of 3 populations

Shaklee Supplements

20+ Years

No Supplements

STUDY DESIGN

• Online Surveys sent to 1000+ qualified candidates

- Diet- Exercise- Health Status

• Measurements taken at 2005 Convention

- Anthropometric- Blood Samples

STUDY DESIGN

And now…..

The long awaited

STUDY RESULTS!

Shaklee Supplement

Users

Single Supplement

Users

NonSupplement

Users

Gender (Female/ Male) 58 / 42 45 / 55 40 / 60

Age 63 57 54BMI (kg/m2) 25.9 27.9 29.4Education> High School 86% 55% 29%

Annual Income> $70,000 62% 35% 33%

Comparison of Demographics

Shaklee Supplements Consumed on a Daily Basis by > 50%

of study participants:

Multivitamin/ mineral Calcium/ Vitamin D

B-complex Flavonoids

Vitamin C Lecithin

Carotenoids Garlic

Vitamin E Alfalfa

Omega-3 Fatty Acids

Soy Protein

Protein

CoQ10

Shaklee Supplement

Users

Other Multivitamin

Users

NonSupplement

Users

Iron-Female

(μg/L) 117.4 74.0 101.7

Iron-Male (μg/L) 117.6 205.2 198.2

Shaklee Supplement

Users

Other Multivitamin

Users

NonSupplement

Users

Vitamin C (mg/dL) 1.62 0.94 0.66Vitamin E (mg/dL) 2.9 1.4 1.1Iron-Female

(μg/L) 117.4 74.0 101.7

Iron-Male (μg/L) 117.6 205.2 198.2Vitamin A (μg/dL) 65.0 64.3 59.2

Vitamin D (nmol/L) 131.4 N/A N/A

Serum Nutrient Concentrations

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

9.69.1

6.1

Homocysteine

Key Biomarkers

HDL Cholesterol

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

50.953.3

57.5

55

Key Biomarkers

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

4.6

3.2

1.9

C-Reactive Protein

3.0

Key Biomarkers

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

180.1

145.3

121.0

Triglycerides

150

Key Biomarkers

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

7.4%

9.1%

2.5%

Heart Health

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

2.5%2.6%

1.8%

Vascular Health

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

Blood Sugar

2.9%

8.5%

11.1%

ShakleeSupplement

Users

OtherMultivitamin

Users

NonSupplement

Users

49%55%

84% Percentage that Rated Very Good to Excellent

Personal Health Assessment

Our Shaklee long-term multiple supplement users had:

IN SUMMARY

Increased Supplement

Intake

Increased Nutrition

Levels

Better Bio-Markers

Better Health

Status

FOUNDATION FOR A LONGER

& HEALTHIER LIFE

Vitalizer™

Dr. Forrest C. ShakleeCreated his first multivitamin in 1915

80 Bio-optimized nutrients clinically provento create a foundation for a longer, healthier life

Vitalizer™

The Vitalizer™ Concept

• UC Berkeley Study

• Comprehensive

• Universal Foundation

• Revolutionary Technology

Vitalizer™ in Numbers

50 Years VMS Experience

75 Shaklee Scientists

3 Years Intensive R&D

12 Shaklee Clinical Studies

80 Nutrients

4 Revolutionary Delivery Systems

12 Patents

= 1 Convenient Daily Dose

2 “Caroto-E-Omega”2 “Caroto-E-Omega”

2 Vita-Lea2 Vita-Lea Super Super Vitamin/Mineral ComplexVitamin/Mineral Complex

1 Sustained-Release B+C1 Sustained-Release B+C

1 Optiflora1 Optiflora Probiotic Probiotic

80 Bio-Optimized Nutrients

• Every Vitamin + Minerals your body needs

• Most powerful antioxidant spectrum

• Anti-aging nutrients

• 7 Omega-3 fatty acids

• Guaranteed super-active probiotics

Redefining VitalitySupercharged Vitality Antioxidant Defense

Heart HealthEye Health

Anti-Aging NutrientsDigestive Function

Stress ManagementBone Health

Joint Function Blood Sugar Support

Lung FunctionHealthy Skin, Hair & Nails

Nerve Function

Muscle Function

Brain Health Enhanced ImmunityDNA Protection

Prostate Health Healthy Teeth & GumsBreast Health

Vitality– Suboptimal Intake of

multiple nutrients:

• Vitamin A – 56%• Vitamin E – 69 %• Vitamin B6 – 54%• Calcium – 65%• Magnesium – 62%• Iron (women) – 62%• Zinc – 73%

USDA CSFII data, 1994-96

– GI Microflora, toxins80 Bio-Optimized Nutrients

Immune NutritionImmune Nutrition

– Vitamin A – 56 %Vitamin A – 56 %– Vitamin E – 69 %Vitamin E – 69 %– Vitamin BVitamin B66 – 54% – 54%– Folic Acid – 33%Folic Acid – 33%– Vitamin BVitamin B1212 – 17% – 17%– Zinc – 73% Zinc – 73% – CarotenoidsCarotenoids

USDA CSFII data, 1994-96USDA CSFII data, 1994-96

Omega-3 Fatty AcidsOmega-3 Fatty AcidsProbioticsProbiotics

Stress ManagementStress Management

Anti-Stress Nutrients: – B-Vitamins– Vitamin C– Magnesium

Shaklee

Micronutrient

Advanced

Release

Technology

SMART

SMART

The Right Nutrients

To the Right Place

At the Right Time!

***12 Patents, 2 Patents Pending***

1) Immediate Release

• Shaklee patented technology

• Folic acid micro-coating

• Releases within minutes in stomach

Vita-Lea® Super Vitamin/Mineral Complex

S MA R T

S MA R T

Immediate ReleaseVita-Lea® – Folic Acid

2) Sustained Release

• Tablet hydrates

• Gel layer forms

• Water soluble nutrients slowly diffuse through gel layer

• Patent pending

Gel-Diffusion Technology for B Vitamins & Vitamin C

S MA R T

S MA R T

Sustained 12+ Hour Release

Thiamine

0.0

20.0

40.0

60.0

80.0

100.0

120.0

140.0

160.0

0 1 2 3 4 5 6 7 8 9 10 11 12

Hours after Supplementation

Pla

sm

a t

ota

l th

iam

in (

nm

ol/

L)

C. Jensen & E. Norkus, UC Berkeley, CA and Our Lady of Mercy Medical Center, Bronx, NY;10 healthy volunteers; sponsored by Shaklee Corporation; submitted for publication

up to almost 200%

3) Delayed Release

• Prevents Omega-3 release in stomach– Creates excellent GI tolerance

• Rapid release in upper GI tract– Maximum bioavailability

• Expensive technology

• Pleasant vanilla aroma

pH-Activated Technology for “Caroto-E-Omega”

S MA R T

S MA R T

Delayed ReleasepH-Activated

4) Targeted Release

• L. acidophilus + B. longum

• Protected from stomach acid

• Release in lower GI tract

Patented Triple-Layer Encapsulation for Probiotics

332211

S MA R T

S MA R T

Targeted ReleaseOptiFlora® – Probiotic

4) Targeted Release

0.57 10

3.5

15

Powder Capsule Soft Gel Tablet OilCoating

Shaklee3x Layer

% Survival, Stomach

90

S MA R T

S MA R T

S.M.A.R.T.—really smart!

Vitalizer™ S.M.A.R.T. Delivery

• Space-saving technology– Using highly concentrated, pure ingredients– 6 versus 10-18!

• Convenience

Vitalizer™ for Everybody

Men 18-49 Women 18-49 Everybody 50+

Once Daily with a Meal

Vitalizer™

• Based on landmark supplement study– 8 of the top products from study are in Vitalizer

• Most complete formula & health benefits– 80 nutrients, 20+ health benefits

• Revolutionary S.M.A.R.T. delivery system– 12 patents, 2 pending

• Most convenient dosage