final propject part 1 presentation
TRANSCRIPT
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Welcome to my presentation
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Effect of Hardness on Disintegration Time –A Study on Marketed Antacid Tablets
A Dissertation Submitted to the Department of Pharmacy State University of Bangladesh in partial
fulfillment of the requirement for the degree of Bachelor of Pharmacy (Hons.)
ID # UG 08-14(B)-09-097
Pharmacy Research LaboratoryDepartment of Pharmacy
State University of Bangladesh
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Introduction
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Purpose of the Project workMeasuring tablet hardness (breaking force) plays a vital role in defining dosage form with optimum physical characteristics and testing whether produced dosage form meets the defined specifications in manufacturing. Testing tablet hardness is more than ensuring the mechanical integrity of produced tablets during subsequent processes. Because the hardness of a tablet directly relates to all other physical parameters, it is a fast and efficient test that indicates whether specifications such as disintegration time and friability will be met.
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Hardness Test of Chewable Tablets
Features of Hardness
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Importance of hardness test
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Measurement of Hardness
Factors Affecting Strength (hardness) of Chewable Tablet
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Hardness Variation
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Chewable Tablet Disintegration
Disintegration Apparatus
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Determination of DisintegrationTime of Tablet
Stopwatch
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Serial no Hardness (kg/cm2) Disintegration Time(Min)Individual Average
1. 17.2
16.71 35 min 2.5 sec.
2. 16.2
3. 17.2
4. 16.1
5. 16.4
6. 17.0
7. 17.2
8. 16.4
9 16.2
10. 17.2
Hardness and Disintegration Time test of Sample A01
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Serial no Hardness (kg/cm2) Disintegration Time(Min)Individual Average
1. 14.2
13.05 25 min 26.5 sec.
2. 12.1
3. 14.0
4. 13.4
5. 11.0
6. 13.4
7. 13.0
8. 12.2
9 14.0
10. 13.2
Hardness and Disintegration Time test of Sample A02
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Serial no Hardness (kg/cm2) Disintegration Time
(Min)Individual Average
1. 11.0
11.78 32 min 11 sec.
2. 13.0
3. 11.0
4. 12.4
5. 10.6
6. 11.0
7. 12.4
8. 13.0
9 11.2
10. 12.2
Hardness and Disintegration Time test of Sample A09
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Sample Code Average Hardness (kg/cm2) Disintegration Time (Min)
A01 16.71 35 min 2.5 sec.A02 13.05 25 min 26.5 sec
A03 14.72 30 min 41.5 sec
A04 11.88 40 min 40.5 sec
A05 12.76 35 min 28 sec
A06 16.52 27 min 38 sec
A07 14.85 28 min 17 sec
A08 09.50 26 min 22.5 sec
A09 11.78 32 min 11 sec
A10 14.72 33 min 23 sec
Overall Hardness and Disintegration Time test of Collected 10 Antacid Samples
From the above table it was revealed that no such relation can establish between hardness and disintegration time. Sample A01 had 16.71 kg/cm2 hardness and DT was 35 min 2.5 sec. Again in sample A09 had 11.78 kg/cm2 hardness and DT was 32 min 11 sec. So no relation can be established between two parameters.
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Conclusion
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Thanks to all