final program - csctr final program.pdffinal program • april 21-22, 2016 • mid-america club •...

Final Program • April 21-22, 2016 • Mid-America Club • Chicago, IL 1 2016 Combined Annual Meeting of CSCTR and MWAFMR

FINAL PROGRAM2016 Combined Annual Meeting

of CSCTR and MWAFMR

April 21-22, 2016The Mid-America Club • Chicago, IL

Central Society for Clinical and Translational Research555 East Wells StreetSuite 1100Milwaukee, WI 53202Phone (414) 273-2209Fax (414) 276-2146E-mail [email protected] www.CSCR.com

Midwestern Section American Federation for Medical Research500 Cummings Center - Suite 4550 Beverly, MA 01915 Phone (978) 927-8330 Fax (978) 524-8890Web www.afmr.org

http://www.CSCR.com


Dear Colleagues,

On behalf of the CSCTR and AFMR Program Committee, I welcome you to the 2016 Combined Annual Meeting.

I hope you have been looking forward to this meeting as much as I have; to learn from the most prestigious leaders in our fields and to collaborate with one another. My sincere hope is that you are able to take much away from this meeting, which will resonate long afterwards in your career.

CSCR (as it was then known) held its first meeting in November 1928, and in October 1969 the first joint meeting of CSCTR and MWAFMR convened. Throughout that long history, our meeting has accomplished its mission to share research techniques, new findings, and learn the latest on the management of diseases and disorders across various subspecialties of medicine.

I extend my sincere appreciation and gratitude to the Program Committee for creating an outstand-ing program. Special thanks go to the many reviewers required to score the five-year record high of 142 abstracts. They are listed on page 24. Are you interested in reviewing abstracts for the 2017 meeting? Return the interest form in your packet to the registration desk, complete the form on the Meeting App, or send an email to [email protected].

In addition to the excellent program be sure to attend the Sugar Club Thursday at 6:30 pm, the Mentor Breakfast 7:30 am Friday – both in Frank Lloyd Wright 1 & 2 – and engage in the Poster Hall 5:00 pm Thursday, and 11:30 am and 3:10 pm Friday in Burnham Ballroom B.

Finally, I encourage you to continue your involvement in CSCTR and/or AFMR. Check out our websites for membership information. And save-the-date for the 2017 Annual Meeting – April 20 & 21 right here at the Mid-America Club.

I hope you enjoy your time at what I believe will be another outstanding Annual Meeting!

Sincerely,

Ellen McCarthy, MD CSCTR President

Welcome

22016 Combined Annual Meeting of CSCTR and MWAFMR Final Program • April 21-22, 2016 • Mid-America Club • Chicago, IL

2016 Combined Annual MeetingLearning ObjectivesThe 2016 Combined Annual Meeting of the Central Society for Clinical and Translational Research (CSCTR) and the Midwestern Section American Federation for Medical Research (MWAFMR) presents the Hickam Lec-ture, Keynote Speaker, two plenary sessions and an oral abstract session on topics of timely interest for researchers and physicians interested in the broad field of clinical research. Participants at the 2016 Combined Annual Meeting will acquire knowledge into clinical research techniques and new findings in various aspects of internal medicine and other fields.

At the completion of the meeting, participants should be able to

• Recognizethevalueofnewresearchtechniques;

• Describenewresearchfindingsincardiology,gastro-enterology, pulmonary and critical care, hematology and oncology, nephrology, infectious disease, allergy, immunology and rheumatology;

• Explainthediagnosisandmanagementofdiseasesanddisorders across various subspecialties of medicine.

This activity has been planned and implemented in accor-dance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Educa-tion (ACCME) through the joint providership of Amedco and the Central Society for Clinical and Translational Research (CSCTR). Amedco is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation StatementAmedco designates this live activity for a maximum of 10.0 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME CertificatesIn order to obtain your AMA PRA Category 1 creditsTM cer-tificate, complete the Credit Verification form included in your syllabus folder. Forms should be completed in full and returned to the registration desk at the end of the meeting.

Faculty/Speaker Disclosure Statement and Disclosure for Discussions of Off Label/Investigational Use of Pharmaceutical ProductsIn accordance with ACCME Standards for Commercial Support of Continuing Medical Education and Amedco’s disclosure policy for CME activities, faculty members have been asked to disclose any relationship they may have with commercial supporters of this CME activity or with com-panies providing products or medical equipment that may have relevance to the content of their presentations. Such

disclosure is intended to provide participants with suffi-cient information to evaluate whether any given presenta-tion has been influenced by the faculty’s relationship(s) or financial interest with said companies.

This activity may include information regarding the off-la-bel and/or investigational use(s) of various pharmacolog-ical agents. The faculty have disclosed below if they will be discussing a product which is still investigational or not labeled for the use under discussion.

Speakers, Moderators, and Panelists’ Disclosure InformationIndividual faculty disclosure information can be found on the handout within your registration packet.


Mid-America Floor Plan


TheMid-AmericaClub•Chicago,Illinois•April21-22,2016

Thursday, April 21, 201610:30 am – 6:00 pm Registration Mid-America Club Lobby

11:00 am – 1:00 pm Poster Author Set-Up Burnham Ballroom B

11:30 am – 3:30 pm CSCTR Council Meeting Burnham Ballroom C

1:00 pm – 4:00 pm MWAFMR Career Development Workshop Burnham Ballroom D

4:00 – 4:15 pm Welcome and CSCTR Business Meeting Burnham Ballroom A

4:15 – 5:00 pm New Investigator Session Burnham Ballroom A

5:00 – 6:30 pm Welcome Reception and Poster Session Burnham Ballroom B

6:30 – 8:00 pm Max Miller Lecture Frank Lloyd Wright 1 & 2

Friday, April 22, 20167:30 am – 3:00 pm Registration Mid-America Club Lobby

7:30 – 8:30 am Mentor Breakfast Frank Lloyd Wright 1 & 2

8:30 – 9:30 am AFMR Keynote Presentation Burnham Ballroom A

9:30 – 10:30 am Department Chair Session I Burnham Ballroom A

10:30 am – 11:30 am Department Chair Session II Burnham Ballroom A

11:30 am – 12:30 pm Poster Session & Lunch Burnham Ballroom B, C, & D

11:30 am – 12:30 pm Editorial Luncheon Meeting Buckingham Boardroom

12:30 – 1:30 pm CSCTR Hickam Lecture Burnham Ballroom A

1:30 – 1:40 pm MWAFMR Scholar’s Award Presentation Burnham Ballroom A

1:40 – 2:10 pm Translational Research Featured New Investigator Lecture

Burnham Ballroom A

2:10 – 3:10 pm Oral Abstract Session I Burnham Ballroom C & D

2:10 – 3:10 pm Oral Abstract Session II Frank Lloyd Wright 1 & 2

3:10 pm – 4:00 pm Closing Poster Session Burnham Ballroom B

2016 Combined Annual Meeting-at-a-Glance


2016 Combined Annual Meeting ScheduleAll sessions jointly presented by: Central Society for Clinical and Translational Research & Midwestern Section American Federation for Medical Research

Thursday, April 21, 2016

1:00 – 4:00 pm Frank Lloyd Wright 1 & 2

MWAFMR Career Cevelopment Workshop

Finding Your Voice in Academic MedicineKarenR.Horowitz,MD,FACPAssociate Professor of Medicine Case Western Reserve University

A Transformational Journey from a Clinician Educator to a Clinician AdministratorAmir K. Jaffer, MD, MBAProfessor Rush University Medical Center

4:00 – 4:15 pm Burnham Ballroom A

Welcome and CSCTR Business Meeting


New Investigator Session

2016 Outstanding Young Investigator Award RecipientPinelopi Kapitsinou, MDUniversity of Kansas Medical Center

2016 ECDA RecipientAlfonso Eirin, MDMayo Clinic

2016 ECDA RecipientDudley W. Lamming, PhDUniversity of Wisconsin-Madison

5:00 – 6:30 pm Burnham Ballroom B

Welcome Reception & Poster SessionA complete listing of posters is located at the back of this program. Outstanding Young Investigator and Oral Abstract Awardees also on display.


56th Annual Max Miller Lecture in Diabetes Research at the Sugar Club

Islet Dysfunction and Death in Diabetes: Too Much Hyp(e)?Raghavendra G. Mirmira, MD, PhDDirector: IU Center for Diabetes and Metabolic Diseases Eli Lilly Foundation Department Professor of Pediatric Diabetes Indiana University School of Medicine

A Novel Incretin Hormone Network in the Pancreatic Islet Promotes Beta-cell SurvivalDawn Belt Davis, MD, PhDAssistant Professor University of Wisconsin - Madison

Novel Nutrient Sensing Receptors in Beta CellsBrian T. Layden, MD, PhDAssistant Professor in Medicine-Endocrinology Northwestern University

Friday, April 22, 2016

7:30 – 8:30 am Frank Lloyd Wright 1 & 2

Mentor BreakfastBreakfast is open to students, junior faculty, trainees, and assis-tant professors who are interested in talking to the experts about their future in academic research. Full breakfast will be served.

8:30 – 9:30 am Burnham Ballroom A

AFMR Keynote Presentation

Donor Derived Infections: Epidemiology, Novel Pathogens and Risk MitigationMichael G. Ison MD, MSAssociate Professor Medicine, Infectious Diseases & Surgery-Or-gan Transplantation Northwestern University Feinberg School of Medicine, Chicago, IL


Department Chair Session IPresiding: Anne Joseph, MD, MPHVice-chair for Faculty Affairs and Diversity University of Minnesota, Minneapolis, MN

Masked Hypertension and Target Organ Damage in CKD: Insights from the CRIC StudyPaulDrawz,MDAssistant Professor of Medicine

Tunneling Nanotubes can Propagate the Bystander Effect following Oncolytic Viral Treatment of Cancer CellsEmil Lou, MD, PhD, FACPAssistant Professor

PELP1 Signaling in Breast Cancer InitiationJulie Ostrander, PhDAssistant Professor of Medicine


2016 Combined Annual Meeting ScheduleAll sessions jointly presented by: Central Society for Clinical and Translational Research & Midwestern Section American Federation for Medical Research


Department Chair Session IIPresiding: Mark W. Geraci, MDChair, Department of Medicine John B. Hickam Professor of Medicine Indiana University School of Medicine

Using Systems Biology Approaches to Understand Natural-ly Acquired Immunity to Malaria

The Impact of XPC on Chronic Smoking-induced Lung Disease Catherine Rufatto Sears, MDAssistant Professor of Medicine

Tuan M. Tran, MD, PhDAssistant Professor of Medicine

Use of Hospice by Nursing Home PatientsKathleen T. Unroe, MDAssistant Professor of Medicine

11:30 am – 12:30 pm Burnham Ballroom B, C, & D

Poster Session & Lunch

12:30 pm – 1:30 pm Burnham Ballroom A

CSCTR Hickam Lecture

Redesign of Care for Patients at Increased Risk of Hospi-talization:TheComprehensiveCarePhysicianModelDavidO.Meltzer,MD,PhDFannie L. Pritzker Professor of Medicine, Economics and Public Policy Chief, Section of Hospital Medicine Director, Center for Health and the Social Sciences (CHeSS) Director, Urban Health Lab


MWAFMR Scholar’s Award Presentation


Featured New Investigator Lecture

Therapeutic Benefits of Young, But Not Old, Adipose-de-rived Mesenchymal Stem Cells in a Chronic Mouse Model of Bleomycin-induced Pulmonary FibrosisJun Tashiro, MD MPHUniversity of Miami Miller School of Medicine Jackson Memorial Hospital

2:10 – 3:10 pm Burnham Ballroom C & D

Oral Abstract Session I

N-TERMINAL REGION OF CARDIAC MYOSIN BINDING PROTEIN-C IS NECESSARY FOR CARDIAC FUNCTIONThomas L. Lynch, IV (PhD)Loyola University

HEMODYNAMIC AND ECHOCARDIOGRAPHIC DIF-FERENCES BETWEEN PRECAPILLARY AND MIXED-TYPE SUBGROUPS OF PULMONARY HYPERTENSIONNicole PristeraCleveland Clinic

GRK2 INHIBITION REDUCES POST-MYOCARDIAL INFARCTION CARDIAC FIBROBLAST MEDIATED AD-VERSE REMODELING MdAbdurRazzaque,PhDUniversity of Wisconsin, Madison


Oral Abstract Session II

KLOTHO, AN ANTI-AGING MOLECULE, REGULATES ALVEOLAR EPITHELIAL CELL MTDNA DAMAGE AND APOPTOSISSeok-Jo Kim, PhDNorthwestern University Feinberg School of Medicine

PROGRESSIVE GLOMERULAR DAMAGE IN SICKLE CELL TRAIT AND SICKLE CELL ANEMIA MOUSE MODELSSantosh L. Saraf, MDUniversity of Illinois at Chicago

ANTIVIRAL INNATE IMMUNE RESPONSES IN HUMAN BRONCHIAL EPITHELIAL CELLS (HBECS) OF SMOK-ERS ARE IMPAIRED THROUGH EPIGENETIC MODIFI-CATIONSWenxin Wu, PhDOklahoma University Health Sciences Center


Welcome Reception and Poster SessionThursday, April 21 5:00 – 6:30 pm • Burnham Ballroom B

Cardiology/Cardiovascular Disease

1 STATINS DECREASE MORTALITY RATE AND LENGTH OF HOSPITALIZATION IN HEART FAILURE PATIENTSH. Alkhawam, J. Sall, J.J. Lieber, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES T.J. Vittorio, St. Francis Hospital - Heart Center, Rosyln, New York, UNITED STATES M. Ka-bach, Univ of Miami, Miller Sch of Medicine, West Palm beach , Florida, UNITED STATES

2 VITAMIN D AND ITS ASSOCIATION IN OBSTRUCTIVE, NON-OBSTRUCTIVE CORONARY ARTERY DISEASE, AND NORMAL CORONARIES ASSESSED ON CORONARY ANGIOGRAPHYR. Sogomonian, H. Alkhawam, J. Jolly, N. Vyas, S. Ahmad, Internal Medicine, Icahn School of Medicine at Mount Sinai Elmhurst Hospital Center, Elmhurst, New York, UNITED STATES E.A. Moradoghli Haftevani, Medicine, Ross Universi-ty, New Jersey, New Jersey, UNITED STATES

3 MORBIDITY AND MORTALITY OF CONGESTIVE HEART FAILURE IN TRAUMA PATIENTS: A RETROSPEC-TIVE CHART ANALTSISH. Alkhawam,A.Al-khazraji,S.Ahmad,J.Lieber,InternalMedicine,IcahnSchoolofMedicineatMountSinai(Elm-hurst), Corona, New York, UNITED STATES R. Madanieh, T.J. Vittorio, St. Francis Hospital – The Heart Center®, Ro-slyn, New York, UNITED STATES M. El-Hunjul, Internal Medicine, Present Saint Joseph Hospital, Chicago, New York, UNITED STATES

4 OUTCOMES IN CONGESTIVE HEART FAILURE PATIENTS UNDERGOING TRANSFEMORAL VERSUS TRAN-SRADIAL CARDIAC CATHETRIZATION: RESTROSPECTIVE CHART ANALYSISH. Alkhawam,R.Sogomonian,N.Vyas,A.Al-khazraji,J.J.Lieber,InternalMedicine,IcahnSchoolofMedicineatMount Sinai (Elmhurst), Corona, New York, UNITED STATES R. Madanieh, T.J. Vittorio, St. Francis Hospital – The Heart Center®, Roslyn, New York, UNITED STATES M. Kabach, Univ of Miami, Miller Sch of Medicine, West Palm beach , Florida, UNITED STATES

5 ISOLATED SUPRA-CARDIAC PARTIAL ANOMALOUS PULMONARY VENOUS CONNECTION CAUSING RIGHT HEART FAILURER. Sogomonian, H. Alkhawam, S. Lee, J. Lieber, Internal Medicine, Icahn School of Medicine at Mount Sinai Elmhurst Hospital Center, Elmhurst, New York, UNITED STATES E.A. Moradoghli Haftevani, Ross University, New Jersey, New Jersey, UNITED STATES

6 HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY IN THE SETTING OF SYSTEMIC SCLERODERMAR. Sogomonian, H. Alkhawam, S. Lee, D. Chang, Internal Medicine, Icahn School of Medicine at Mount Sinai Elmhurst Hospital Center, Elmhurst, New York, UNITED STATES E.A. Moradoghli Haftevani, Ross University, New Jersey, New Jersey, UNITED STATES

7 VENOUS THROMBOEMBOLISM (VTE) AFTER ROUTINE KNEE ARTHROSCOPY IN 10 PATIENTS WITH PRE-VIOUSLY UNKNOWN FAMILIAL THROMBOPHILIAV. Jetty, M. Prince, P. Wang, C.J. Glueck, Cholesterol and Metabolism Center, The Jewish Hospital, Cincinnati , Ohio, UNITED STATES

9 AN IL7 MONOCLONAL ANTIBODY RESCUES HYPOXIA-MEDIATED PULMONARY HYPERTENSION IN MICEH. Gao, Y. Dong, R. Machado, J. Chen, Medicine, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES H. Gao,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan,CHINA

10 FRAGMENTED QRS DOES NOT PREDICT ONSET OF HEART FAILURE WITH PRESERVED EJECTION FRAC-TION IN PATIENTS WITH DIASTOLIC DYSFUNCTIONI. Karagodin, Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES J.L. Strande, Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES B. Marong, Medical Student, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES



11 REDOX PROFILING OF CARVEDILOL AND PROPRANOLOL IN A HEART MODELP. Marathe, M. Thao, I. Benjamin, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES

13 BILATERAL UPPER EXTREMITY ECCHYMOTIC, BRUISING, AND BLEEDING IN A PATIENT ON ALIROCUM-AB, RIVAROXABAN, AND ANTI-PLATELET THERAPYD. Shah, D. Glueck, Internal Medicine, Jewish-Mercy Cholesterol and Metabolism Center, Cincinnati, Ohio, UNITED STATES

15 ELIGIBILITY FOR PCSK9 THERAPY IN CHOLESTEROL CENTER PATIENTS WITH INITIAL LDL CHOLES-TEROL ≥ 130 BUT <160 MG/DLK. Lee, C. Glueck, M. Prince, Jewish Hospital Cincinnati, Cincinnati, Ohio, UNITED STATES

16 INAPPROPRIATE DEFIBRILLATION DUE TO ELCTRO-MAGNETIC INTERFERENCE FROM NEARBY ALTER-NATING CURRENTA. Hassan, R. Sajjad, Internal Medicine, The Jewish Hospital, West Chester, Ohio, UNITED STATES

136 N-TERMINAL REGION OF CARDIAC MYOSIN BINDING PROTEIN-C IS NECESSARY FOR CARDIAC FUNCTIONM. Sivaguru, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, UNITED STATES T.L. Lynch, D.W. Kuster, S. Govindan, S. Sadayappan, Department of Cell and Molecular Physiology, Loyola University Chi-cago, Maywood, Illinois, UNITED STATES M.J. Previs, D.M. Warshaw, Department of Molecular Physiology and Biophysics, The University of Vermont, Burlington, Vermont, UNITED STATES K. Lee, R. Craig, Department of Cell and Develop-mental Biology, University of Massachusetts Medical School, Worcester, Massachusetts, UNITED STATES

137 GRK2 INHIBITION REDUCES POST-MYOCARDIAL INFARCTION CARDIAC FIBROBLAST MEDIATED AD-VERSE REMODELINGM.Razzaque, J.L. Philip, X. Xu, M. Han, J. Li, S.A. Akhter , Surgery, University of Wisconsin, Madison, Wisconsin, UNITED STATES

138 HEMODYNAMIC AND ECHOCARDIOGRAPHIC DIFFERENCES BETWEEN PRECAPILLARY AND MIXED-TYPE SUBGROUPS OF PULMONARY HYPERTENSIONN. Pristera,CaseWesternReserveUniversitySchoolofMedicine,ClevelandHeights,Ohio,UNITEDSTATESR.Schilz,Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, UNITED STATES B. Hoit, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleve-land, Ohio, UNITED STATES

Endocrinology/Metabolism

18 DIABETES AND PRE-ECLAMPSIA: A RETROSPECTIVE CROSS-SECTIONAL STUDY OF PREGNANCY OUTCOMESJ.L. Wilson, Texas A&M Health Science Center College of Medicine, Smithville, Texas, UNITED STATES R.R. Kalagiri, T. Carder, M.R. Beeram, T.J. Kuehl, M. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center CollegeofMedicine,Temple,Texas,UNITEDSTATESS.H.Afroze,D.C.Zawieja,MedicalPhysiology,TexasA&MHealthScience Center College of Medicine, Temple, Texas, UNITED STATES T.J. Kuehl, M. Uddin, Obstetrics and Gynecology, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES

19 ELIGIBILITY FOR PCSK9 TREATMENT IN 734 HYPERCHOLESTEROLEMIC PATIENTS REFERRED TO A REGIONAL CHOLESTEROL TREATMENT CENTER WITH LDL CHOLESTEROL ≥70 MG/DL DESPITE MAXIMAL TOLERATED CHOLESTEROL LOWERING THERAPYP. Shah, C. Glueck, N. Goldenberg, V. Jetty, A. Kumar, M. Goldenberg, P. Wang, Internal Medicine, Jewish-Mercy Cho-lesterol and Metabolism Center, Cincinnati, Ohio, UNITED STATES N. Motayar, M. Prince, K. Lee, Internal Medicine, Jewish Hospital, Cincinnati, Ohio, UNITED STATES

20 HOSPITALIZATION FOR PULMONARY EMBOLISM ASSOCIATED WITH ANTECEDENT TESTOSTERONE OR ESTROGEN THERAPY IN PATIENTS FOUND TO HAVE FAMILIAL THROMBOPHILIAM. Rothschild, A. Vijaykumar, M. Goldenberg, N. Motayar, J. Weber, M. Prince, C. Glueck, P. Wang, Internal Medicine, The Jewish Hospital, Cincinnati, Ohio, UNITED STATES



21 ALTERNATIVE RAPAMYCIN TREATMENT REGIMENS MITIGATE THE IMPACT OF RAPAMYCIN ON GLU-COSE HOMEOSTASIS AND THE IMMUNE SYSTEM, AND EXTENDS LIFESPANS. Arriola Apelo, C.P. Pumper, E.L. Baar, N.E. Cummings, H.K. Brar, M.E. Kimple, D.W. Lamming, Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Wisconsin-Madison, Madison, Wisconsin, UNITED STATES J.C. Neuman, Interdisciplinary Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, UNITED STATES S. Arriola Apelo, J.C. Neuman, C.P. Pumper, E.L. Baar, N.E. Cummings, H.K. Brar, M.E. Kimple, D.W. Lamming, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, UNITED STATES

22 DIFFERENTIAL ACTIONS OF ESTROGEN RECEPTOR α AND β VIA NON-GENOMIC SIGNALING IN HUMAN PROSTATE STEM-PROGENITOR CELLSS. Majumdar, J.C. Rinaldi, T. Gauntner, L. Xie, W. Hu, G.S. Prins, Urology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES N. Malhotra, S. Kasper, University of Cincinnati, Cincinnati, Ohio, UNITED STATES

23 LONG DELAY IN ACCURATE DIAGNOSIS OF HNF1A-MODY IN THE US MONOGENIC DIABETES REGISTRYR.N. Naylor, J.T. Montgomery, K. Lindauer, L. Letourneau, A. Bindal, M. Sanyoura, D. Carmody, S.W. Greeley, L.H. Philipson, University of Chicago, Chicago, Illinois, UNITED STATES

Epidemiology/Health Care Outcomes/Quality Improvement/Bioinformatics

24 BENEFITS AND RISKS OF WARFARIN WITH AND WITHOUT ASPIRIN IN PATIENTS WITH CORONARY AR-TERY DISEASE OR CEREBROVASCULAR ACCIDENT: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALSA. Deshpande, K. Patel, M.B. Rothberg, Medicine, Cleveland Clinic, Cleveland, Ohio, UNITED STATES V. Pasupuleti, Medicine, Case Western Reserve University, Cleveland, Ohio, UNITED STATES G. Alreja, Medicine, Baystate Medical Center,Springfield,Massachusetts,UNITEDSTATESI.L.Katzan,CerebrovascularCenter,ClevelandClinic,Cleveland,Ohio, UNITED STATES

25 SOCIAL DETERMINANTS OF PATIENT ANTIBIOTIC MISUSE IN HARYANA, INDIAA. Barker, K. Verhoeven, Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, UNITED STATES M. Ahsan, S. Alam, P. Sharma, S. Sengupta, Medanta Medicity Hospital, Gurgaon, INDIA N. Safdar, Medicine, University of Wisconsin-Madison, Madison, Wisconsin, UNITED STATES N. Safdar, William S. Middleton Veterans Af-fairs Hospital, Madison, Wisconsin, UNITED STATES

26 EXPLORING THE LONGITUDINAL TRANSCRIPTOMIC LANDSCAPE OF TYROSINE KINASE INHIBITOR TREATMENT RESPONSE IN CHRONIC MYELOID LEUKEMIA PATIENTSA. Nath, F. Wang, D. Lenkala, B. LaCroix, N. Glavin, K. Kipping-Johnson, P. Geeleher, E. Rich, M. Thirman, L. Godley, G. Raca, R. Larson, R. Huang, Medicine, The University of Chicago, Chicago, Illinois, UNITED STATES

27 K2 ABUSE SERIOUS THREAT TO NEW YORK STATEA.Al-khazraji, B. Garrido, H. Alkhawam, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Elm-hurst, New York, UNITED STATES

Gastroenterology/Clinical Nutrition

28 ACQUIRED IMMUNODEFICIENCY SYNDROME RELATED KAPOSI SARCOMA A RARE INTRUDER AFFECT-ING THE STOMACHN. Vyas, H. Alkhawam, Internal Medicine, Elmhurst Hospital Center, Queens, New York, UNITED STATES S. Ahmad, R. Companioni, R. Sogomonian, J. Aron, Gastroenterology, Icahn School of Medicine at Mount Sinai (Elmhurst) , Elm-hurst, New York, UNITED STATES

29 INVASIVE LIVER ABSCESS SYNDROME IN NORTH AMERICAA.Al-khazraji, H. Alkhawam, B. Garrido, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Elm-hurst, New York, UNITED STATES



30 HEPATITIS B VIRUS REACTIVATION IN AN INACTIVE CARRIER OF CHRONIC HBV AFTER THE INITIA-TION OF TREATMENT FOR TIBERCULOSISA.Al-khazraji, H. Alkhawam, B. Garrido, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Elm-hurst, New York, UNITED STATES

31 VIRAL CYTOMEGALOVIRUS IN GRANULOMATOSIS WITH POLYANGIITISA.Al-khazraji, H. Alkhawam, B. Garrido, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Elm-hurst, New York, UNITED STATES

32 AGENESIS OF GALLBLADDER PRESENTING WITH OBSTRUCTIVE JAUNDICEA.Al-khazraji, H. Alkhawam, B. Garrido, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Elm-hurst, New York, UNITED STATES

34 ASSOCIATION BETWEEN VITAMIN D AND GASTRIC CANCERN. Vyas, H. Alkhawam, R. Sogomonian, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Queens, New York, UNITED STATES R.A. Ching Companioni, A. Walfish, J. Baum, Gastroenterology, Icahn School of Medicine at Mount Sinai (Elmhurst), Elmhurst, New York, UNITED STATES

35 ASSOCIATION BETWEEN HELICOBACTER PYLORI INFECTION WITH CORONARY ARTERY DISEASE AND ACUTE MYOCARDIAL INFARCTION: A RETROSPECTIVE CHART ANALYSISN. Vyas, H. Alkhawam, E. Saker, R. Sogomonian, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elm-hurst), Queens, New York, UNITED STATES R.A. Ching Companioni, A. Walfish, R. Bansal, Gastroenterology, Icahn School of Medicine at Mount Sinai (Elmhurst), Elmhurst, New York, UNITED STATES

36 PEGASPARGASE INDUCED SEVERE PANCREATITIS. FRIEND OR FOE?N. Vyas, H. Alkhawam, R. Sogomonian, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Queens, New York, UNITED STATES R.A. Ching Companioni, M. Tiba, A. Walfish, Gastroenterology, Icahn School of Medicine at Mount Sinai (Elmhurst), Queens, New York, UNITED STATES

37 SILENT BUT DEADLY CYTOMEGALOVIRUS TRIGGERING AUTOIMMUNE HEPATITISN. Vyas, H. Alkhawam, R. Sogomonian, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Queens, New York, UNITED STATES R.A. Ching Companioni, A. Walfish, Gastroenterology, Icahn School of Medicine at Mount Sinai (Elmhurst), Elmhurst, New York, UNITED STATES

38 PRIMARY SQUAMOS CELL CARCINOMA OF THE RECTUMN. Vyas, H. Alkhawam, R. Sogomonian, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Queens, New York, UNITED STATES S. Ahmad, R.A. Ching Companioni, M. Tiba, J. Aron, Gastroenterology, Icahn School of Medicine at Mount Sinai (Elmhurst), Elmhurst, New York, UNITED STATES

Genetic & Molecular Medicine

39 RETINAL VASCULAR OCCLUSION: A WINDOW TO DIAGNOSIS OF FAMILIAL AND ACQUIRED THROM-BOPHILIA AND HYPOFIBRINOLYSIS, WITH IMPORTANT RAMIFICATIONS FOR OCULAR AND NON-OCULAR THROMBOSIS.S.G. Dixon, C.T. Bruce, C.J. Glueck, P. Wang, Jewish Hospital Cholesterol and Metabolism Center, Cincinnati, Ohio, UNITED STATES R.K. Hutchins, M.A. Sisk, Cincinnati Eye Institute, Cincinnati, Ohio, UNITED STATES R.K. Hutchins, University of Cincinnati, Cincinnati, Ohio, UNITED STATES

40 OPHTHALMOLOGISTS SHOULD ASSESS FOR THROMBOPHILIA, A MAJOR CAUSE OF CENTRAL RETINAL ARTERY AND CENTRAL RETINAL VEIN OCCLUSION.S.G. Dixon, C.T. Bruce, C.J. Glueck, P. Wang, Jewish Hospital Cholesterol and Metabolism Center, Cincinnati, Ohio, UNITED STATES R.K. Hutchins, R.A. Sisk, Cincinnati Eye Institute, Cincinnati, Ohio, UNITED STATES R.K. Hutchins, University of Cincinnati, Cincinnati, Ohio, UNITED STATES



41 THROMBOTIC RAMIFICATIONS OF OPHTHALMOLOGIC DIAGNOSIS OF FAMILIAL AND ACQUIRED THROMBOPHILIA AS PATHOETIOLOGY FOR OTHERWISE UNEXPLAINED UVEITIS.C.T. Bruce, S.G. Dixon, C.J. Glueck, P. Wang, Jewish Hospital Cholesterol and Metabolism Center, Cincinnati, Ohio, UNITED STATES R.K. Hutchins, Cincinnati Eye Institute, Cincinnati, Ohio, UNITED STATES R.K. Hutchins, Universi-ty of Cincinnati, Cincinnati, Ohio, UNITED STATES

Geriatrics

42 FACTORS ASSOCIATED WITH TREATMENT SEEKING IN VETERANS WITH LATE-ONSET PTSDS. Ramaswamy, A. Hickert, K. Miller, School of Medicine, Creighton University, Omaha, Nebraska, UNITED STATES S. Ramaswamy, V. Kolli, D. Driscoll, Y. KC, A. Hickert, K. Miller, VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska, UNITED STATES

Hematology and Oncology

43 INSULIN RESISTANCE AND ENDOMETRIAL CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSISP. Thota, V. Pasupuleti, Case Western Reserve University, Cleveland, Ohio, UNITED STATES V.A. Benites-Zapata, Uni-versidad de San Martin de Porres, Lima, PERU A. Deshpande, Cleveland Clinic, Cleveland, Ohio, UNITED STATES F.R. Perez-Lopez,UniversityofZaragoza,Zaragoza,SPAINA.V.Hernandez,UniversidadPeruanadeCienciasAplicadas,Lima, PERU

44 LOCAL CONTROL OF OCULAR ADNEXAL LYMPHO-PROLIFERATIVE DISORDERS (OALD): SIMILAR OUT-COMES IN MALT AND NON-MALT HISTOLOGIESB. Dhakal, S. Ramalingam, T. Fesnke, M. Hamadani, Hematology/Oncology, Medical College of Wisconsin, Milwau-kee, Wisconsin, UNITED STATES L. Rein, Biosatistics, Medical College of WIsconisn, Milwaukee, Wisconsin, UNIT-ED STATES J. Shuff, B. Ericskon, Radiation Oncology, Medical College of Wiscosin, Milwaukee, Wisconsin, UNITED STATES

45 EVALUATION OF CELLULAR MECHANISMS BY WHICH CINOBUFOTALIN INHIBITS OVARIAN CANCER CELL LINES FUNCTIONS.H.Afroze, D.C. Zawieja, Medical Physiology, Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES R. Tobin, C. Peddaboina, M.K. Newell-Rogers, Surgery, Texas A&M Health Science Center College of Medicine/Baylor Scott & White Health, Temple, Texas, UNITED STATES A.C. McDowell, T.C. McCormick, T.J. Kuehl, M.N. Uddin, Obstetrics and Gynecology, Texas A&M Health Science Center College of Medicine/Baylor Scott & White Health, Temple, Texas, UNITED STATES T.J. Kuehl, M.N. Uddin, Pediatrics, Texas A&M Health Science Center College of Medicine/Baylor Scott & White Health, Temple, Texas, UNITED STATES

47 TESTOSTERONE-HCG THERAPY ASSOCIATED WITH RECURRENT DEEP VENOUS THROMBOSIS-PULMO-NARY EMBOLISM DESPITE ANTICOAGULATION IN A 55 YEAR OLD MAN WITH THROMBOPHILIAK. Lee, C. Glueck, Jewish Hospital Cincinnati, Cincinnati, Ohio, UNITED STATES

Infectious Disease

48 VEILLONELLA BACTEREMIA IN AN IMMUNOCOMPROMISED PATIENTJ. Kim, M. Beilke, infectious diseases, Medical college of Wisconsin affiliated hospital, Milwaukee, Wisconsin, UNITED STATES

49 STUDY OF MINIMUM INHIBITORY CONCENTRATION OF CEFAZOLIN FOR METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS AND CORRELATION WITH OXACILLIN SUSCEPTIBILITYC. Quarshie, J. Koirala, V. Sundareshan, internal medicine, SIU School of Medicine, Springfield, Illinois, UNITED STATES

51 CHEMOTHERAPEUTIC POTENTIAL OF LIPOXINS IN KAPOSI’S SARCOMA AND PRIMARY EFFUSION LYM-PHOMAX.M. Huang, A.C. Hwang, N. Sharma-Walia, Department of MIcrobiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medical Sciences, North Chicago, Illinois, UNITED STATES



52 NATIVE VALVE INFECTIVE ENDOCARDITIS CAUSED BY STAPHYLOCOCCUS WARNERIB. Bhardwaj, U. Bhatnagar, Internal Medicine , UMKC, Mission, Kansas, UNITED STATES

54 CUTANEOUS MUCORMYCOSIS IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA: A PHARMACO-LOGICAL DILEMMAC.E. Figueroa Castro, Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES

Nephrology

55 FIBRILLARY GLOMERULONEPHRITIS:LOOKS LIKE AMYLOID BUT ITS NOT!Z. Asad, Internal Medicine, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES A. Chaudhary, Medicine, Nishtar Medical College, Multan, Punjab, PAKISTAN U.Z. Bhutta, Nephrology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES

139 PROGRESSIVE GLOMERULAR DAMAGE IN SICKLE CELL TRAIT AND SICKLE CELL ANEMIA MOUSE MODELSS.L. Saraf, J.R. Sysol, J.A. Arruda, R.F. Machado, V.R. Gordeuk, Medicine, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES A. Susma, S. Setty, Pathology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES K.P. Gudehithlu, A.K. Singh, Medicine, John H. Stroger, Jr Hospital of Cook County, Chicago, Illinois, UNITED STATES

Pediatrics

56 COMPARISON OF OUTCOMES BETWEEN NORMAL AND PREECLAMPTIC PREGNANCIES: A PROSPECTIVE STUDYR.R. Kalagiri, M.R. Beeram, V. Govande, T.J. Kuehl, M.N. Uddin, Pediatrics, Baylor Scott & White/Texas A&M Health ScienceCenterCollegeofMedicine,Temple,Texas,UNITEDSTATESS.H.Afroze,MedicalPhysiology,TexasA&MHealth Science Center College of Medicine, Temple, Texas, UNITED STATES M. Reyes, N.N. Drever, S.R. Allen, T.J. Kuehl, M.N. Uddin, Obstetrics and Gynecology, Baylor Scott & White Health/Texas A&M Health Science Center Col-lege of Medicine, Temple, Texas, UNITED STATES

57 PRE-GESTATIONAL DIABETES AND PREECLAMPSIA IN BANGLADESHI PATIENTS: A RETROSPECTIVE STUDYM. Jahan, S. Mahbuba, S. Shaha, H. Akhter, G.U. Ahsan, Department of Public Health, North South University, Dhaka, Dhaka, BANGLADESH T. Islam, JICA , Dhaka, Dhaka, BANGLADESH T.J. Kuehl, M.N. Uddin, Obstetrics and Gyne-cology, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES T.J. Kuehl, M.N. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES

Pulmonary/Critical Care

58 ACUPUNCTURE THERAPY, AN UNDERREPORTED CAUSE OF PNEUMOTHORAXT. Abdo, V. Kha, H. Bhardwaj, H. Youness, Pulmonary and Critical Care, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES

59 ROLE OF ENDOTHELIAL HYPOXIA – INDUCIBLE FACTORS IN HYPOXIA-INDUCED PULMONARY VASO-CONSTRICITONY. Gu,H.Tang,J.G.Garcia,J.X.Yuan,DepartmentofMedicine,TheUniversityofArizona,Tucson,Arizona,UNITEDSTATES D.R. Fraidenburg, J. Chen, Department of Medicine, University of Illinois, Chicago, Illinois, UNITED STATES A.Makino,J.X.Yuan,DepartmentofPhysiology,TheUniversityofArizona,Tucson,Arizona,UNITEDSTATES

60 ZINC DEFICIENCY PRIMES THE LUNG FOR VENTILATOR INDUCED LUNG INJURYJ. Englert, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, UNITED STATES F. Boudreault, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, UNITED STATES M. Pinilla-Vera, C. Isabelle, A. Arciniegas, C. Quintana, D. Amador, R.M. Baron, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, UNITED STATES A. Kho, Children’s Hospital Informatics Program, Boston Children’s Hospital, Boston, Massachusetts, UNITED STATES D.J. Tschumperlin, Departments of Physiology and Biomedical Engineering, May Clinic, Rochester, Minnesota, UNITED STATES



61 WARFARIN, HEMOTHORAX & THROMBOLYTICSS. Naqvi, K.S. Allen, Pulmonary & Critical Care Medicine, University of Oklahoma Health Sciences Center, Edmond, Oklahoma, UNITED STATES

62 HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS CAUSED BY INFECTION BY EHRLICHIA CHAFFEENSIS: A CASE REPORT.L.P. Nguyen, Pulmonary and Critical Care, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES

63 RAPID 3D PRECLINICAL QUANTITATIVE LUNG IMAGING WITH ULTRASHORT-ECHO TIME (UTE) MRI IN A MOUSE MODEL OF CYSTIC FIBROSIS LUNG DISEASEC. Anderson, C. Flask, Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, UNITED STATES C. Flask, Radiology, Case Western Reserve University, Cleveland, Ohio, UNITED STATES

64 REVERSIBLE BLINDNESS ASSOCIATED WITH DIABETIC KETOACIDOSIS: A RARE COMBINATIONZ. Asad, Internal Medicine, University Of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES A. Chaudhary, Medicine, Nishtar Medical College, Multan, Punjab, PAKISTAN A. Awab, Pulmonary and Crit-ical Care, University Of Oklahoma Health Sciences Centeriversity Of Oklahoma Health Sciences Center, Oklahoma, Oklahoma, UNITED STATES

113 THE ENDOTHELIAL PHD2/HIF-2 AXIS REGULATES PULMONARY ARTERY PRESSURE IN MICEP.P. Kapitsinou, G. Rajendran , L. Astleford, M.P. Schonfeld, Medicine/ Nephrology, University of Kansas Medical Center, Kansas City, Kansas, UNITED STATES M. Michael, S. Shay, J.L. French , J. West , V.H. Haase, Vanderbilt University, Nash-ville, Tennessee, UNITED STATES T. Fields , University of Kansas Medical Center, Kansas City, Kansas, UNITED STATES

140 KLOTHO, AN ANTI-AGING MOLECULE, REGULATES ALVEOLAR EPITHELIAL CELL MTDNA DAMAGE AND APOPTOSISS. Kim, P. Cheresh, R.P. Jablonski, D.W. Kamp, Division of Pulmonary & Critical Care Medicine, Northwestern Univer-sity Feinberg School of Medicine, Chicago, Illinois, UNITED STATES M. Eren, D.E. Vaughan, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois, UNITED STATES

141 ANTIVIRAL INNATE IMMUNE RESPONSES IN HUMAN BRONCHIAL EPITHELIAL CELLS (HBECS) OF SMOKERS ARE IMPAIRED THROUGH EPIGENETIC MODIFICATIONSW. Wu, W. Zhang, J.L. Booth, X. Wang, J. Metcalf, Medicine, University of Oklahoma Health Sciences Center, Oklaho-ma City, Oklahoma, UNITED STATES

Rheumatology/Immunology/Allergy

65 HYDROGEL MICROSPHERES FOR SPATIOTEMPORALLY CONTROLLED DELIVERY OF RNAI TO STEM CELLS FOR CHONDROGENESISA.F. McMillan, Pathology, Case Western Reserve University, Cleveland, Ohio, UNITED STATES E. Alsberg, BME, Case Western Reserve University, Cleveland , Ohio, UNITED STATES

66 HENOCH-SCHONLEIN PURPURA (HSP) PRESENTING AS A LARGE PERICARDIAL EFFUSION IN AN ADULTA. Hassan, R. Sajjad, Internal Medicine, The Jewish Hospital, West Chester, Ohio, UNITED STATES

67 HENOCH-SCHONLEIN PRPURA WITH A NEGATIVE SKIN BIOPSYS. AKBAR, N. AKBAR, A. KUBBARA, Internal Medicine, University of Toledo Medical Center, Toledo, Ohio, UNITED STATES


Lunch; Closing Poster SessionFriday, April 22 11:30 am – 12:30 pm; 3:10 – 4 pm • Burnham Ballroom B

Cardiology/Cardiovascular Disease

8 30-DAY READMISSION RATE OF PATIENTS UNDERGOING CORONARY CARDIAC CATHETERIZATION IN THE AMBULATORY VERSUS IN-HOSPITAL SETTINGH. Alkhawam, R. Sogomonian, N. Vyas, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES J. Sayanlar, D. Rubinstein, Cardiology, Icahn School of Medicine at Mount Sinai (Elmhurst), New York, New York, UNITED STATES M. Kabach, Univ of Miami Miller School of Medicine, West Palm beach , Florida, UNITED STATES

12 THE ROLE OF ALCOHOL ABUSE AND TOBACCO USE IN THE INCIDENCE OF EARLY ACUTE CORONAY SYNDROMEH. Alkhawam, M. Mariya Fabisevich , R. Sogomonian, J.J. Lieber, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES R. Madanieh, A. Madanieh, T.J. Vittorio, St. Francis Hospital – The Heart Center®, Roslyn, New York, UNITED STATES M. El-hunjul, Internal Medicine, Present Saint Joseph Hospi-tal, Chicago, Illinois, UNITED STATES

14 DIGITALIS INCREASES THE 30-DAY READMISSION RATE IN PATIENTS WITH HEART FAILURE AND RE-DUCED EJECTION FRACTIONH. Alkhawam, J. Sall, J.J. Lieber, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES T.J. Vittorio, St. Francis Hospital - Heart Center(r), Roslyn, New York, UNITED STATES

17 GRAVES DISEASE INDUCED DILATED CARDIOMYOPATHYH. Alkhawam,N.Vyas,R.Sogomonian,A.Al-khazraji,InternalMedicine,IcahnSchoolofMedicineatMountSinai(Elmhurst), Corona, New York, UNITED STATES M. Kabach, University of Miami Miller School of Medicine, West Palm Beach, Florida, UNITED STATES

68 CORONARY ARTERY DISEASE AND ACUTE CORONARY SYNDROME IN PATIENTS ≤ 40 YEAR OLDH. Alkhawam,R.Sogomonian,N.Vyas,A.Al-khazraji,S.Ahmed,J.J.Lieber,InternalMedicine,IcahnSchoolofMed-icine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES M. El-Hunjul, Internal Medicine, Saint Joseph Hospital, Chicago, Chicago, Illinois, UNITED STATES R. Madanieh, T.J. Vittorio, St. Francis Hospital – The Heart Cen-ter®, Roslyn, New York, UNITED STATES

69 MARINOBUFAGENIN-INDUCED ANTI-ANGIOGENIC MILIEU IN CYTOTROPHOBLASTS IS ATTENUATED BY NOVEL ANTI-MBG ANTIBODIESA.F. Pantho,UniversityofTexasatAustin,Temple,Texas,UNITEDSTATESS.H.Afroze,D.C.Zawieja,MedicalPhysiol-ogy, Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES J.M. Wages, J.W. Larrick, Panorama Research, Inc., Sunnyvale, California, UNITED STATES T.J. Kuehl, M.N. Uddin, Obstetrics and Gynecology, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES T.J. Kuehl, M.N. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center College of Medi-cine, Temple, Texas, UNITED STATES

70 ENDOTHELIAL CELL PROTEIN KINASE PKD-1 SIGNALING IS ESSENTIAL FOR IMPROVING TISSUE ISCH-EMIA VIA ARTERIOGENIC REPROGRAMMINGB. Ren, R.L. Silverstein, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES B. Ren, R. Yuan, L. Dong, R.L. Silverstein, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin, UNITED STATES L. Dong, Department of Pharmacology, Anhui Medical University, Hefei, CHINA

71 PRAVASTATIN PROTECTS A SW-71 CYTOTROPHOBLAST CELL LINE FROM A HYPERGLYCEMIA-INDUCED PREECLAMPSIA PHENOTYPEM. Reyes, N.N. Drever, S.R. Allen, T.J. Kuehl, M. Uddin, Obstetrics and Gynecology, Baylor Scott & White/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES T.J. Kuehl, M. Uddin, Pediatrics, Bay-lor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES S.H.Afroze,D.C.Zawieja,MedicalPhysiology,TexasA&MHealthScienceCenterCollegeofMedicine,Temple,Texas,UNITED STATES M.M. Costantine, Obstetrics and Gynecology, UTMB, Galveston, Texas, UNITED STATES



72 INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) ATTENUATES EXPERIMEN-TAL PULMONARY HYPERTENSIONJ. Chen, J.R. Sysol, K.M. Shioura, S. Singla, H. Yamamura, A. Yamamura, V. Reddy, J. Torres, A. Sridhar, H. Tang, J.X. Yuan, J.G. Garcia, R.F. Machado, Medicine, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES J.R. Sysol, R.F. Machado, Pharmacology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES H. Tang, J.X. Yuan,J.G.Garcia,Medicine,UniversityofArizona,Tucson,Arizona,UNITEDSTATES

73 ATHEROTHROMBOSIS, THROMBOPHILIA, AND RELENTLESS PROGRESSION OF CORONARY ARTERY DISEASED. Ayalew, M. Prince, N. Motayar, P. Shah, J. Glueck, P. Wang, Internal Medicine Department, Jewish Hospital of Cincin-nati, Cincinnati, Ohio, UNITED STATES

74 A RETROSPECTIVE STUDY OF CORONARY ARTERY DISEASE IN PATIENTS WITH BODY MASS INDEX ≥30H. Alkhawam, R. Sogomonian, R. Desai, J. Jolly, N. Vyas, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES J. Sayanlar, D. Rubinstein, Cardiology, Mount Sinai School of Med-icine, New York, New York, UNITED STATES M. Kabach, University of Miami, Miller School of Medicine, West Palm Beach , Florida, UNITED STATES

76 AVOIDING TRANSTHORACIC ECHOCARDIOGRAPHY (TTE) AND TRANSESOPHAGEAL ECHOCARDIOGRA-PHY (TEE) FOR PATIENTS WITH VARIABLE BODY MASS INDEXES (BMI) IN INFECTIVE ENDOCARDITISR. Sogomonian, H. Alkhawam, N. Vyas, J. Jolly, A. Ashraf, Internal Medicine, Icahn School of Medicine at Mount Sinai Elmhurst Hospital Center, Elmhurst, New York, UNITED STATES E.A. Moradoghli Haftevani, Ross University, New Jersey, New Jersey, UNITED STATES

77 FAST-SKELETAL MYOSIN BINDING PROTEIN-C REGULATES SKELETAL MUSCLE CALCIUM SENSITIVITYB.L. Lin, S. Govindan, S. Sadayappan, Cell and Molecular Physiology, Loyola University Chicago, Evanston, Illinois, UNITED STATES L. Zhao, J. Xu, R. Han, Department of Surgery, Ohio State University, Columbus, Ohio, UNITED STATES

Endocrinology/Metabolism

78 IMPROVING GLYCEMIC CONTROL THROUGH REDUCTION OF SPECIFIC DIETARY AMINO ACIDSD. Lamming, N. Cummings, S. Arriola Apelo, J. Neuman, B. Schmidt, M. Merrins, M. Kimple, Medicine, University of Wisconsin-Madison, Madison, Wisconsin, UNITED STATES D. Lamming, N. Cummings, S. Arriola Apelo, J. Neuman, B. Schmidt, M. Merrins, M. Kimple, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, UNITED STATES L. Fontana, Geriatrics and Nutritional Science, Washington University in St. Louis, St. Louis, Missouri, UNIT-ED STATES

79 INSULIN TREATMENT INCREASES MICROVESICULAR INSULIN-DEGRADING ENZYME IN DIABETES.M.V. Purbaugh,C.V.Desouza,R.Heineman,R.G.Bennett,F.G.Hamel,InternalMedicine,UniversityofNebraskaMed-cial Center, Omaha, Nebraska, UNITED STATES M.V. Purbaugh,C.V.Desouza,R.G.Bennett,F.G.Hamel,Research,Omaha VA Medical Center, Omaha, Nebraska, UNITED STATES

80 IMPACT OF CYCLOOXYGENASE-2 DELETION ON ADIPOSE TISSUE INFLAMMATION AND SYSTEMIC META-BOLIC HOMEOSTASIS IN OBESITYV. Saraswathi,C.Perriotte-Olson,G.Natarajan,C.V.Desouza,InternalMedicine/DivisionofDiabetes,Endocrinology,and Metabolism , University of Nebraska Medical Center, Omaha, Nebraska, UNITED STATES V. Saraswathi, C. Perri-otte-Olson,G.Natarajan,C.V.Desouza,Endocrinology,VANebraska-WesternIowaHealthCareSystem,Omaha,Nebras-ka, UNITED STATES



81 NANOFORMULATED COPPER/ZINC SUPEROXIDE DISMUTASE CAUSES MUSCLE METABOLIC ALTER-ATIONS AND IMPROVES SYSTEMIC INSULIN SENSITIVITY IN MICEG. Natarajan,C.Perriotte-Olson,C.Desouza,S.Viswanathan,InternalMedicine/DEM,UNMC,Omaha,Nebraska,UNITED STATES G. Natarajan,C.Perriotte-Olson,C.Desouza,S.Viswanathan,VeteransAdministrationNebras-ka-Western Iowa Health Care System, Omaha, Nebraska, UNITED STATES D. Manickam, A.V. Kabanov, Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy,, University of North Carolina at Chapel Hill, Chapel Hill , North Carolina, UNITED STATES

82 DISTINCT ACTIONS OF ERα AND ERβ IN HUMAN PROSTATE STEM AND PROGENITOR CELL SELF-RENEW-AL AND DIFFERENTIATIOND. HU, W. Hu, S. Majumdar, T. Gauntner, Y. Li, G. Shi, S. Kasper, G.S. Prins, Urology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

83 PRODUCTION OF SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS FOLLOWING ACUTE AEROBIC EXERCISE IS GENDER SPECIFICE.R. Miranda, J.T. Mey, B.K. Blackburn, J.M. Haus, Kinesiology and Nutrition, University of Illinois at Chicago, Oak Park, Illinois, UNITED STATES S.S. Farabi, L. Quinn, Biobehavioral Health Science, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

84 β CELL DERIVED MIR-21 INCREASES APOPTOSIS VIA TRANSLATIONAL INHIBITION OF THE ANTIAPOP-TOTIC PROTEIN BCL2 AND COULD SERVE AS A BIOMARKER OF TYPE 1 DIABETES MELLITUSE.K. Sims, Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, Indiana, UNITED STATES A. Lakhter, I. Restrepo, X. Tong, T. Kono, E. Anderson-Baucum, C. Evans-Molina, Indiana University School of Medicine, Indianapolis, Indiana, UNITED STATES

85 CROSS-TALK BETWEEN ESTROGEN RECEPTORS AND INSULIN-LIKE GROWTH FACTOR TYPE-1 RECEP-TOR MODULATES HUMAN PROSTATE STEM/PROGENITOR CELL AMPLIFICATIONJ.D. Rinaldi, W. Hu, S. Majumdar, D. Hu, G.S. Prins, Urology, UIC, Chicago, Illinois, UNITED STATES J.D. Rinaldi, L. Justulin, S.L. Felisbino, Morfologia, Universidade Estadual Paulista, Botucatu, Sao Paulo, BRAZIL

86 SAFETY OF 50,000-100,000 UNITS OF VITAMIN D3 PER WEEK IN VITAMIN D DEFICIENT, HYPERCHOLES-TEROLEMIC PATIENTS, WITH STATIN INTOLERANCEV. Jetty, G. Duhon, P. Shah, M. Prince, K. Lee, M. Goldenberg, A. Kumar, C.J. Glueck, P. Wang, Cholesterol and Metabo-lism Center, The Jewish Hospital, Cincinnati , Ohio, UNITED STATES

87 TRANSCRIPTION FACTOR CREB3L3 IS A NOVEL REGULATOR FOR ADIPOCYTE BIOLOGY AND METABOLISMS. Duncan, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, UNITED STATES M. McCann, G. Qiang, V. Gil, H. Whang Kong, C. Liew, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

88 PHOSPHOLIPID BASED LIPOIDTM NANOEMULSION OF CURCUMIN IN LINSEED OIL SHOWED IN-CREASED BIOAVAILABILITY AND ASSISTS IN ELEVATING THE LEVELS OF DOCOSAHEXAENOIC ACID IN SERUM AND LIVER LIPIDS OF RATSS. Dhavamani, Department of Endocrinology and metabolism, University of Illinois, Chicago, Illinois, UNITED STATES B. Lokesh, lipid science department, CFTRI, MYSORE, karnataka, INDIA

Gastroenterology/Clinical Nutrition

33 ACUTE PANCREATITIS WITH NORMAL LIPASE AND AMYLASE ENZYMESH. Alkhawam,C.Catalano,F.Zaiem,N.Vyas,M.Fabisevich,A.Al-khazraji,InternalMedicine,IcahnSchoolofMedicineat Mount Sinai (Elmhurst), Corona, New York, UNITED STATES



89 RESIDENTIAL SEGREGATION AND SPATIAL CLUSTERING OF COLONOSCOPY RESOURCES WITHIN THE CITY OF CHICAGOK. Naylor, O. Kassim, K. Kim, Medicine, University of Chicago, Chicago, Illinois, UNITED STATES

Genetic & Molecular Medicine

90 ADAM10 REGULATES STEMNESS OF ADULT NEURAL STEM CELLS BY MEDIATING THEIR POSITIONING WITHIN THE SVZ NICHEN. McMillan, Neurobiology, Stony Brook University, East Setauket, New York, UNITED STATES

Hematology and Oncology

91 ST2 BLOCKADE REDUCES SST2-PRODUCING T CELLS WHILE MAINTAINING PROTECTIVE MST2-EX-PRESSING T CELLS DURING GRAFT-VERSUS-HOST DISEASEJ. Zhang,A.Ramadan,B.Griesenauer,W.Li,M.Turner,R.Kapur,H.Hanenberg,S.Paczesny,IndianaUniversitySchool of Medicine, Indianapolis, Indiana, UNITED STATES C. Liu, University of Florida College of Medicine, Gaines-ville,Florida,UNITEDSTATESB.Blazar,UniversityofMinnesota,Minneapolis,Minnesota,UNITEDSTATESI.Tawara,Mie University Hospital, Mie, JAPAN

93 STRUCTURE-ACTIVITY RELATIONSHIPS OF SYNTHESIZED QUERCETIN DERIVATIVES ON ANTI-PROLIF-ERATION AND ANTI-MIGRATION ACTIVITY IN B16 MELANOMA CELLSK. Yamauchi,S.H.Afroze,MedicalPhysiology,TexasA&MHealthScienceCenterCollegeofMedicine,Temple,Texas,UNITED STATES K. Yamauchi, T. Mitsunaga, United Graduate School of Agricultural Science, Gifu University, Gifu, Gifu, JAPAN M. Uddin, Obstetrics and Gynecology, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES M. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES

95 IL-33/ST2 TRIGGERING OF IL-9–SECRETING T CELLS: FROM PROTEOMICS TO THERAPEUTICSA. Ramadan, J. Zhang, M. Abu Zaid, L. Taylor, H.A. O’Leary, R. Kapur, H. Hanenberg, H.E. Broxmeyer, M.H. Kaplan, S. Paczesny,IndianaUniversity-schoolofmedicine,Indianapolis,Indiana,UNITEDSTATES

96 CINOBUFOTALIN AS A NOVEL AGENT TO INHIBIT IN-VITRO EPITHELIAL OVARIAN CANCER CELL PRO-LIFERATION, MIGRATION AND INVASIONA. McDowell, T.C. McCormick, T.J. Kuehl, M. Uddin, Obstetrics and Gynecology, Baylor Scott & White Health/Texas A&MHealthScienceCenterCollegeofMedicine,Temple,Texas,UNITEDSTATESS.H.Afroze,D.C.Zawieja,MedicalPhysiology, Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES T. Richard, M.K. Newell-Rogers, Surgery, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES T.J. Kuehl, M. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES

Infectious Disease

50 PERFORATED DIVERTICULOSIS COMPLICATED WITH ACTINOMYCOSIS INFECTION AND PRESENTED AS PELVIC MALIGNANCYH. Alkhawam,S.Lee,R.Sogomonian,N.Vyas,A.Al-khazraji,A.Ashraf,InternalMedicine,IcahnSchoolofMedicineatMount Sinai (Elmhurst), Corona, New York, UNITED STATES

53 SEVER SYMPTOMATIC BABESIOSIS CO-INFECTION WITH LYME DISEASEH. Alkhawam, F. Zaiem, S. Lee, M. Fabisevich, A. Ashraf, Internal Medicine, Icahn School of Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES



97 MYCOBACTERIUM MUCOGENICUM IN HEMATOPOEITIC STEM CELL TRANSPLANT RECIPIENTS AND IN HIGH-RISK PATIENTS WITH HEMATOLOGIC MALIGNANCIES, 2008-2013M. Abidi, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES A. Baner-jee, N. Ledeboer, P. Hari, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES

98 EFFECTIVENESS OF DAILY CHLORHEXIDINE BATHING FOR REDUCING GRAM NEGATIVE INFECTIONS: A META-ANALYSISA. Patel, P. Parikh, A. Deshpande, Center for Value Based Care Research, Cleveland Clinic, Cleveland, Ohio, UNITED STATES J.A. Otter, Imperial College Healthcare NHS Trust, London, UNITED KINGDOM P. Thota, Vancive Medical Technologies, an Avery Dennison business, Chicago, Illinois, UNITED STATES C. Donskey, Department of Infectious Diseases, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, UNITED STATES T. Fraser, A. Deshpande, De-partment of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, UNITED STATES

99 PREVELNACE, MORBIDTY AND MORTALITY OF INFECTIVE ENDOCARDITIS IN THE MOST DIVESE AREA OF USA IN NEW YORK CITYH. Alkhawam,R.Sogomonian,F.Zaiem,N.Vyas,J.Jolly,A.Al-khazraji,A.Ashraf,InternalMedicine,IcahnSchoolof Medicine at Mount Sinai (Elmhurst), Corona, New York, UNITED STATES M. El-hunjul, Internal Medicine, Saint Joseph Hospital, Chicago, Chicago, Illinois, UNITED STATES

100 A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE RELATIVE EFFICACY AND SAFETY OF TREATMENT REGIMENS FOR HIV-ASSOCIATED CEREBRAL TOXOPLASMOSISP. Thota, V. Pasupuleti, Case Western Reserve University , Cleveland, Ohio, UNITED STATES D. Pellegrino, Emilio Ribas Institute of Infectious Diseases, Sao Paulo, BRAZIL V.A. Benites-Zapata, Universidad de San Martin de Porres, Lima, PERU A. Deshpande, Cleveland Clinic, Cleveland, Ohio, UNITED STATES J.E. Vidal, University of Sao Paulo, SaoPaulo,BRAZILA.V.Hernandez,UniversidadPeruanadeCienciasAplicadas,Lima,PERU

101 ROTHIA MUCILAGINOSA BACTEREMIA: 8 YEAR REVIEW OF A SINGLE INSTITUTION EXPERIENCE.M. Abidi, P. Hari, Department of Medicine, Medical College of Wisconsin, Brookfield, Wisconsin, UNITED STATES A. Banerjee, N. Ledeboer, Medical College of Wisconsin, Milwaukee, Wisconsin, UNITED STATES

103 COMPARATIVE ANTIMICROBIAL EFFICACY OF TWO HAND-HYGIENE PRODUCTS IN INTENSIVE CARE UNITS: A RANDOMIZED CONTROLLED TRIALA. Deshpande, J. Fox, S. Schramm, Medicine, Cleveland Clinic, Cleveland, Ohio, UNITED STATES A. Deshpande, K.K. Wong, T.G. Fraser, S. Gordon, Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, UNITED STATES C.J. Donskey, Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, UNITED STATES

Nephrology

104 CINOBUFOTALIN HINDERS CYTOTROPHOBLASTS FUNCTION VIA CELL CYCLE ARRESTG.C. Osuji, M. Reyes, N.N. Drever, T.J. Kuehl, M.N. Uddin, Obstetrics and Gynecology, Baylor Scott & White/Texas A&MHealthScienceCenterCollegeofMedicine,Temple,Texas,UNITEDSTATESS.H.Afroze,D.C.Zawieja,MedicalPhysiology, Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES M.R. Beeram, T.J. Kuehl, M.N. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES

105 COMPARISON OF PLACENTAL AND PLASMA SOLUBLE (PRO)RENIN RECEPTOR IN NORMAL AND PRE-ECLAMPTIC PREGNANCYS. Choudhury, Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES M. Reyes, N.N. Drever, S.R. Allen, T.J. Kuehl, M.N. Uddin, Obstetrics and Gynecology, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES M.R. Beeram, T.J. Kuehl, M.N. Uddin, Pediatrics, Baylor Scott & White Health/Texas A&M Health Science Center College of Medicine, Temple, Texas, UNITED STATES S.H.Afroze,D.C.Zawieja,MedicalPhysiology,TexasA&MHealthScienceCenterCollegeofMedicine,Temple,Texas,UNITED STATES



Pulmonary/Critical Care

106 ALVEOLAR ESCAPE BY BACILLUS ANTHRACIS SPORES DOES NOT REQUIRE A CARRIER CELL AND IS NOT ALTERED BY LETHAL TOXINJ.L. Booth, E.S. Duggan, V.I. Patel, J. Metcalf, Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES M. Langer, K.M. Coggeshall, Immunobiology and Cancer, Oklahoma Medical Re-search Foundation, Oklahoma City, Oklahoma, UNITED STATES A. Braun, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, GERMANY

107 MITOXANTRONE INHIBITS TGFβ1- INDUCED SIGNALING THROUGH PROMOTING TGFβ RECEPTOR II DEGRADATIONA.M. Jacko, L. Nan, J. Wei, J. Zhao, Y. Zhao, Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, UNITED STATES

108 DEUBIQUITINATING ENZYME 11 STABILIZES TGFβ RECEPTOR II AND REGULATES TGFβ1 SIGNALING IN PULMONARY FIBROBLASTJ. Wei, A.M. Jacko, L. Nan, J. Zhao, J. Tan, D.J. Kass, Y. Zhao, Medicine, University of Pittsburgh, Pittsburgh, Pennsylva-nia, UNITED STATES

109 PARKIN MEDIATES ENDOTHELIAL PRO-INFLAMMATORY RESPONSES IN ACUTE LUNG INJURYE. Letsiou, H. Wang, P. Belvitch, S. Dudek, Medicine, University of Illinois at Chicago, Chicago, Illinois, UNITED STATESS.Sammani,UniversityofArizona,Tucson,Arizona,UNITEDSTATES

110 GENETIC AND EPIGENETIC REGULATION OF MYOSIN LIGHT CHAIN KINASE BY INFLAMMATORY LUNG DISEASE ASSOCIATED POLYMORPHISMSX. Sun,.R.Elangovan,Y.Shimizu,T.Wang,J.G.Garcia,Medicine,UniversityofArizona,Tucson,Arizona,UNITEDSTATES S. Ma, Medicine, University of Chicago, Chicago, Illinois, UNITED STATES

111 THE S1P TRANSPORTER, SPNS2, MEDIATES HGF-INDUCED LAMELLIPODIA FORMATION AND MIGRA-TION OF HUMAN LUNG ENDOTHELIAL CELLSP. Fu,P.V.Usatyuk,D.L.Ebenezer,V.Natarajan,UniversityofIllinoisatChicago,Chicago,Illinois,UNITEDSTATES

112 ROLE OF PHOSPHOLIPASE D IN IDIOPATHIC PULMONARY FIBROSISV. Suryadevara, T. Royston, Bioengineering, University of Illinois, Chicago, Chicago, Illinois, UNITED STATES E. Berdyshev, National Jewish Health, Denver, Colorado, UNITED STATES L. Huang, V. Natarajan, Pharmacology, Univer-sity of Illinois, Chicago, Chicago, Illinois, UNITED STATES A. Tager, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, UNITED STATES

113 THE ENDOTHELIAL PHD2/HIF-2 AXIS REGULATES PULMONARY ARTERY PRESSURE IN MICEP.P. Kapitsinou, G. Rajendran , L. Astleford, M.P. Schonfeld, Medicine/ Nephrology, University of Kansas Medical Cen-ter, Kansas City, Kansas, UNITED STATES M. Michael, S. Shay, J.L. French, J. West, V.H. Haase, Vanderbilt University, Nashville, Tennessee, UNITED STATES T. Fields , University of Kansas Medical Center, Kansas City, Kansas, UNITED STATES

114 AN ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR1, AM966, INCREASES PULMONARY ENDO-THELIAL PERMEABILITY THROUGH ACTIVATION OF VE-CADHERINJ. Cai, J. Wei, A.M. Jacko, J. Zhao, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, UNITED STATES

115 TRKA TRANSACTIVATION BY LYSOPHOSPHATIDIC ACID REGULATES LUNG EPITHELIAL CELL MIGRA-TIONL. Nan, J. Wei, J. Zhao, A.M. Jacko, Y. Zhao, University of Pittsburgh, Pittsburgh, Pennsylvania, UNITED STATES V. Natarajan, Pharmacology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES L. Nan, H. Ma, Anesthe-siology, Jilin University, Changchun, Jilin, CHINA



116 ADNIBISTRATION OF SPHINGOSINE KINASE 1 INHIBITOR POST-BLEOMYCIN CHALLENGE ATTENU-ATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE: ROLE OF YAP1L. Huang, V. Natarajan, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

117 SIRT3, THE MAJOR ANTI-AGING MITOCHONDRIAL DEACETYLASE, IS IMPORTANT FOR PREVENTING PULMONARY FIBROSISR. Jablonski, S. Kim, P. Cheresh, D.B. Williams, D. Kamp, Pulmonary and Critical Care, Northwestern University Fein-berg School of Medicine, Chicago, Illinois, UNITED STATES

118 UBIQUITIN E3 LIGASE FIEL1 REGUALTES TGFBETA SIGNALING IN LUNG FIBROBLASTJ.Y. Zhao, B. Chen, Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, UNITED STATES

119 PATHOGENIC ROLES OF CALCIUM-SENSING RECEPTORS AND TRANSIENT RECEPTOR POTENTIAL CA-NONICAL CHANNELS 6 IN THE DEVELOPMENT AND PROGRESSION OF PULMONARY HYPERTENSIONH. TANG, Y. Gu, S.M. Black, J.G. Garcia, A. Makino, J.X. Yuan, Department of Medicine, Division of Translational and RegenerativeMedicine,TheUniversityofArizona,Tucson,Arizona,UNITEDSTATESA.Yamamura,SchoolofPharma-cy, Kinjo Gakuin University , Nagoya, JAPAN D.R. Fraidenburg, J. Chen, Department of Medicine, University of Illinois, Chicago, Illinois, UNITED STATES H. TANG, S.M. Black, J.G. Garcia, A. Makino, J.X. Yuan, Department of Physiology, TheUniversityofArizona,Tucson,Arizona,UNITEDSTATES

120 REGULATION OF ENDOTHELIAL BARRIER PERMEABILITY BY PHOSPHOLIPASE D2M. Shaaya, P. Fu, A. Karginov, V. Natarajan, Cellular and Molecular Pharmacology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

122 THE LINK BETWEEN OBSTRUCTIVE SLEEP APNEA AND LUNG CANCER: A RETROSPECTIVE CASE CON-TROL STUDYG. Salem, Internal Medicine Department, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES R. Jambeih, Sleep Medicine, Emory University, Atlanta, Georgia, UNITED STATES H. Hussein, H. Bhardwaj, J. Keddissi, H. Youness, Department Of Pulmonary and Critical Care, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, UNITED STATES

123 ROLE OF MICRORNA-1 IN REGULATING PULMONARY VASCULAR REMODELING IN PULMONARY ARTE-RIAL HYPERTENSIONJ.R. Sysol, J. Chen, S. Singla, V. Natarajan, R.F. Machado, University of Illinois at Chicago, Chicago, Illinois, UNITED STATESS.Comhar,S.C.Erzurum,ClevelandClinic,Cleveland,Ohio,UNITEDSTATES

124 ABL FAMILY KINASES MEDIATE LUNG VASCULAR PERMEABILITY AND INFLAMMATION IN ACUTE LUNG INJURYA.N.Rizzo, E. Letsiou, S. Dudek, Medicine, UIC College of Medicine, Chicago, Illinois, UNITED STATES X. Sun, J.G. Garcia,Medicine,UniversityofArizona,Tuscon,Arizona,UNITEDSTATES

125 ROLE OF TRPM2 IN SPHINGOLIPID-MEDIATED RADIATION-INDUCED LUNG INJURYY. Epshtein, H. Wang, J. Jacobson, Medicine, UIC, Chicago, Illinois, UNITED STATES A.B. Malik, Pharmacology, UIC, Chicago, Illinois, UNITED STATES

126 ROLE OF SYNDECAN-1 IN MECHANICAL STRESS-INDUCED LUNG ENDOTHELIAL CELL INFLAMMATORY RESPONSES MEDIATED BY INTEGRIN BETA4W. Chen, R.O. Dull, J.R. Jacobson, Medicine, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

127 DECREASED CPAP ADHERENCE IN NON-OBESE OSA PATIENTS WITH REVERSIBLE UPPER AIRWAY OB-STRUCTIONJ. Doumit, P. Belvitch, I. Rubinstein, Pulmonary Critical Care and Sleep, UIC, Chicago, Illinois, UNITED STATES J. Doumit, P. Belvitch, I. Rubinstein, Internal Medicine/PCCSM, Jesse Brown VA, Chicago, Illinois, UNITED STATES



128 FTY720 S-PHOSPHONATE DOES NOT ACTIVATE GRK2-MEDIATED S1PR1 PHOSPHORYLATION AND DEG-RADATIONL. Wang, S. Dudek, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES B. Robert, The City University of New York, New York, New York, UNITED STATES

129 PARTICULATE MATTER DISRUPTS ENDOTHELIAL CELL PERMEABILITY VIA GAP JUNCTION PROTEINX. Wu,X.Xu,J.Garcia,T.Wang,DepartmentofMedicine,UniversityofArizona,Tucson,Arizona,UNITEDSTATESX. Xu, Department of Respiratory Medicine and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, CHINA

130 NOVEL ROLE FOR LYSOCARDIOLIPIN ACYLTRANSFERASE (LYCAT) IN NON-SMALL CELL LUNG CANCERM.M. Van Scoyk, S. Avasarala, R.A. Winn, R. Bikkavilli, V. Natarajan, Pulmonary, Critical Care, Sleep and Allergy, De-partment of Medicine, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES S.R. Kotha, L. Huang, V. Natarajan, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, UNITED STATES

131 ACTIN RELATED PROTEIN 2/3 COMPLEX REGULATES ACTIN MEMBRANE STRUCTURES TO DETER-MINE ENDOTHELIAL BARRIER FUNCTIONP. Belvitch, S. Dudek, Pulmonary and Critical Care, University of Illinois at Chicago, CHICAGO, Illinois, UNITED STATESM.E.Brown,UniversityofChicago,Chicago,Illinois,UNITEDSTATESJ.G.Garcia,UniversityofArizona,Tuc-son,Arizona,UNITEDSTATES

Rheumatology/Immunology/Allergy

132 LUPUS KERATINOCYTES ARE PRIMED BY AN AUTOCRINE TYPE I INTERFERON LOOP TO ROBUSTLY SECRETE IL-6J.N. Stannard, T.J. Reed, J.M. Kahlenberg, Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, UNITED STATES E.M. Myers, Internal Medicine, Division of Rheumatology, Georgetown University, Washington, District of Columbia, UNITED STATES L. Lowe, J.E. Gudjonsson, Dermatology, University of Michigan, Ann Arbor, Michigan, UNITED STATES

133 SINGLE CELL GENE EXPRESSION IN CLASSICAL MONOCYTES CORRELATES WITH TREATMENT RE-SPONSE TO TNF-ALPHA INHIBITION IN RHEUMATOID ARTHRITIST.WamplerMuskardin,Z.Jin,J.Dorschner,M.Jensen,T.Bongartz,K.Wright,T.Mason,S. Persellin, C. Michet, D. John, E. Matteson, T. Niewold, Rheumatology, Mayo Clinic, Rochester, Minnesota, UNITED STATES W. Fan, Rheuma-tology, Shanghai Jiao Tong University, Shanghai, CHINA

135 SINGLE CELL GENE EXPRESSION STUDIES IN LUPUS MONOCYTES REVEAL A UNIQUE ANTII-INFLAM-MATORY NON-CLASSICAL MONOCYTE POPULATION ASSOCIATED WITH CLINICAL QUIESCENCEZ. Jin, M.A. Jensen, J.M. Dorschner, D.M. Vsetecka, S. Amin, A. Makol, F. Ernste, T. Osborn, K. Moder, V. Chowdhary, T.B. Niewold, Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, Minnesota, UNITED STATES W. Fan, Department of Rheumatology, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, CHINA


Congratulations to all awardees

ORAL ABSTRACT AWARD RECIPIENTS ($500 award)

Seok-Jo Kim, PhD ~ Northwestern University Feinberg School of MedicineThomas L. Lynch, IV ~ Loyola University ChicagoNicole Pristera ~ Case Western Reserve University School of MedicineMdAbdurRazzaque,PhD~ University of Wisconsin, MadisonSantosh L. Saraf, MD ~ University of Illinois at ChicagoWenxin Wu, PhD ~ Oklahoma University Health Sciences Center

OUTSTANDING YOUNG INVESTIGATOR AWARD RE-CIPIENT ($2,000 award)

Pinelopi Kapitsinou, MD ~ University of Kansas Medical Center

K AWARD RECIPIENTS ($1,000 award)

Joshua A. Englert, MD ~ The Ohio State University Wexner Medical CenterJ. Michelle Kahlenberg, MD, PhD ~ University of MichiganBin Ren, MD, PhD ~ Medical College of WisconsinSantosh L. Saraf, MD ~ University of Illinois at ChicagoEmily K. Sims, MD ~ Indiana University School of MedicineMohammad N. Uddin, PhD, FAHA ~ Baylor Scott & White Health/Texas A&M Health Science CenterSaraswathi Viswanathan, PhD ~ University of Nebraska Medical CenterTheresa Wampler Muskardin, MD ~ Mayo Clinic

MWAFMR SCHOLAR AWARD RECIPIENTS

Anastasia Jacko ~ University of PittsburghJianxin Wei, MD, MS ~ University of PittsburghXiaoguang Sun, MD, PhD ~ University of ArizonaPanfeng Fu, PhD ~ University of Illinois at ChicagoVidyani Suryadevara, MS ~ University of IllinoisAditi Patel, MD ~ Center for Value Based Care Research

TRAINEE TRAVEL AWARD RECIPIENTS ($300 or $600 award)

Tony Abdo, MD ~ The University of Oklahoma Health Sciences CenterMaheen Abidi, MD ~ Medical College of WisconsinSyedaH.Afroze,PhD~ Texas A&M Health Science Center College of MedicineNuralhuda Akbar, MBBS ~ University of Toledo Medical CenterHassan Alkhawam, MD ~ Icahn School of Medicine at Mount Sinai (Elmhurst)Christain Anderson ~ Case Western Reserve UniversitySebastian I. Arriola Apelo, PhD ~ University of Wisconsin-MadisonZain Ul Abideen Asad, MD ~ Oklahoma University Health Sciences CenterAnna Barker ~ University of Wisconsin-MadisonPatrick G. Belvitch, MD ~ University of Illinois at ChicagoBhaskar Bhardwaj, MD ~ University of Missouri School of Medicine

2016 Combined Annual Award Winners

Junting Cai ~ University of Pittsburgh, Department of MedicineJiwang Chen, PhD ~ University of Illinois at ChicagoWeiguo Chen, MD, PhD ~ University of Illinois at ChicagoSaiara Choudhury ~ Texas A&M Health Science CenterAbhishek Deshpande, MD, PhD ~ Cleveland ClinicBinod Dhakal, MD ~ Medical College of WisconsinStephan G. Dixon, MD ~ Jewish Hospital CincinnatiJimmy Doumit, MD ~ University of Illinois at ChicagoYulia Epshtein, PhD ~ University of Illinois at ChicagoPanfeng Fu, PhD ~ University of Illinois at ChicagoHui Gao, MD, PhD ~ University of Illinois at ChicagoYali Gu ~ The University of ArizonaAtif Hassan, MD ~ The Jewish HospitalLongshuang Huang, PhD ~ University of Illinois at ChicagoXiao M. Huang ~ Chicago Medical School, Rosalind Franklin Uni-versity of Medicine and ScienceHussein Hussein, MD ~ Oklahoma University Health Sciences CenterAnastasia M. Jacko ~ University of PittsburghMobashera Jahan, MPH ~ North South UniversityVybhav Jetty, MD ~ The Jewish HospitalRam R. Kalagiri, MD ~ Baylor Scott & White/Texas A&M Health Science Center College of MedicineDudley W. Lamming, PhD ~ University of Wisconsin-MadisonEleftheria Letsiou, PhD ~ University of Illinois at ChicagoBrian Lin, PhD ~ Loyola University ChicagoThomas L. Lynch, IV ~ Loyola University ChicagoShyama Majumdar, PhD ~ University of Illinois at ChicagoMaximilian McCann ~ University of Illinois at ChicagoAnthony B. McDowell, Jr., MD ~ Baylor Scott & White Health/Texas A&M Health Science Center College of MedicineAlexandra McMillan ~ Case Western Reserve UniversityNadia F. McMillan ~ Stonybrook University MSTPEdwin R. Miranda, MS ~ University of Illinois at ChicagoLing Nan ~ University of PittsburghSyed J. Naqvi, MD ~ University of Oklahoma Health Sciences CenterGopalakrishnan Natarajan, PhD ~ University of Nebraska Medical CenterAritro Nath, PhD ~ University of ChicagoLoan P. Nguyen, MD ~ University of Oklahoma Health Sciences CenterGrace-Ann Osuji ~ Baylor Scott & White/Texas A&M Health Science Center College of MedicineAhmed F. Pantho ~ University of Texas at AustinAditi M. Patel, MD ~ Cleveland ClinicMatthew V. Purbaugh ~ University of Nebraska Medical CenterAbdulraouf Ramadan, PhD ~ Indiana University School of MedicineMdAbdurRazzaque,PhD~ University of Wisconsin, MadisonJaqueline C. Rinaldi, MD, PhD ~ University of Illinois at Chicago


Mark Shaaya, BS ~ University of Illinois at ChicagoParth Shah, MD ~ Jewish-Mercy Cholesterol and Metabolism CenterRobert Sogomonian, MD, MBA ~ Icahn School of Medicine at Mount Sinai Elmhurst Hospital CenterXiaoguang Sun, MD, PhD ~ University of ArizonaVidyani Suryadevara, MS ~ University of Illinois at ChicagoJustin R. Sysol ~ University of Illinois College of Medicine at ChicagoHaiyang Tang, PhD ~ University of ArizonaPriyaleela Thota, MD ~ Case Western Reserve UniversityNeil Vyas, MD ~ Elmhurst Hospital Center

2016 Combined Annual Award Winners

Council Members

President Ellen McCarthy, MD Kansas City, KS

President-Elect Roy Silverstein, MD Milwaukee, WI

Vice President Abraham Thomas, MD, MPH Brooklyn, NY

Central Society for Clinical and Translational Research

Secretary-Treasurer Terry G. Unterman, MD Chicago, IL

Immediate Past President Roy E. Weiss, MD, PhD Miami, FL

Editor Jeffrey Laurence, MD New York, NY

Councilors Carmella Evans-Molina, MD, PhD Indianapolis, IN

Kieren J. Mather, MD Indianapolis, IN

Francis Miller, MD Durham, NC

Timothy B. Niewold, MD Rochester, MN

Debra Romberger, MD Omaha, NE

Brad H. Rovin, MD Columbus, OH

Midwestern Section American Federation for Medical Research

Chair Armand Krikorian, MD, FACE Chicago, IL

Chair-Elect Suthat Liangpunsakul, MD, MPH Indianapolis, IN

Secretary-Treasurer Dawn B. Davis, MD, PhD Madison, WI

Past Chair Florence Rothenberg, MS, MD Cincinnati, OH

Councilors Kristina Bailey, MD Omaha, NE

Mark A. Beilke, MD Milwaukee, WI

Joumana T. Chaiban, MD Cleveland, OH

Sriram Ramaswamy, MD Omaha, NE

Vijay Shivaswamy, MBBS, MS Omaha, NE

Xiaoguang Sun, MD, PhD Research Associate Professor Tucson, AZ

Richard R. Watkins, MD, MS, FACP Akron, OH

Yutong Zhao, MD, PhD Pittsburgh, PA

Lichun Wang, PhD ~ University of Illinois at ChicagoJianxin Wei, MD, MS ~ University of PittsburghJessica Wilson ~ Texas A&M Health Science Center College of MedicineXiaomin Wu, PhD ~ University of ArizonaKosei Yamauchi, PhD ~ Texas A&M Health Science Center College of MedicineJoe Y. Zhao ~ University of Pittsburgh


Kristina Bailey, MD University of Nebraska Medical Center Omaha, NE

Joe K. Bissett, MD University of Arkansas Little Rock, AR

SuzanneF.Bradley University of Michigan Medical School Ann Arbor, MI

Joumana T. Chaiban, MD Washington University Cleveland, OH

Sung Won Choi, MD MS University of Michigan Medical School Ann Arbor, MI

Alejandro Comellas, MD University of Iowa Iowa City, IA

Emily K. Curran, MD University of Chicago Medicine Chicago, IL

Nicholas O. Davidson, MD, DSc Washington University School of Medi-cine Saint Louis, MO

Dawn Belt Davis, MD, PhD University of Wisconsin - Madison Madison, WI

Abhishek Deshpande, MD, PhD Cleveland Clinic Cleveland, OH

Steven Dudek, MD University Illinois at Chicago Chicago, IL

Carmella Evans-Molina, MD, PhD Indiana University School of Medicine Indianapolis, IN

David A. Fox University of Michigan Ann Arbor, MI

Joseph A. Franciosa, MD SUNY Downstate New York, NY

Jay L. Goldstein, MD NorthShore University Health System Evanston, IL

Special Acknowledgement—Abstract ReviewersRami Y. Haddad, MD, FACP University of Illinois at Chicago Oak Lawn, IL

Brian D. Hoit, MD Case Western Reserve University Cleveland, OH

Erik Allen Imel, MD Indiana University School of Medicine Indianapolis, IN

Mark A. Jensen, PhD Mayo Clinic Rochester, MN

Kichul Ko, MD University of Chicago Medicine Chicago, IL

Armand Krikorian University of Illinois at Chicago/Advo-cate Christ Medical Center Oak Lawn, IL

Jeffrey Laurence, MD Weill Cornell Medical College Greenwich, CT

Suthat Liangpunsakul, MD, MPH Indiana University School of Medicine Westfield, IN

Pradeep P.A. Mammen, MD, FACC, FAHA UT Southwestern Medical Center Dallas, TX

Kieren J. Mather, BSc, MD Indiana University-Division of Endocri-nology Indianapolis, IN

Ellen McCarthy, MD University of Kansas Medical Center Kansas City, KS

Francis Miller, MD Duke University Durham, NC

Debra Romberger, MD University of Nebraska Medical Center Omaha, NE

Ann K. Rosenthal, MD Medical College of Wisconsin Milwaukee, WI

Florence Rothenberg, MS, MD, FA University of Cincinnati Cincinnati, OH

Brad H. Rovin, MD The Ohio State University Wexner Med-ical Center Columbus, OH

Eric T. Rush, MD University of Nebraska Medical Center Omaha, NE

Vijay Shivaswamy, MBBS, MS University of Nebraska Medical Center Omaha, NE

Roy Silverstein, MD Medical College of Wisconsin Milwaukee, WI

Emily K. Sims, MD Indiana University School of Medicine Carmel, IN

DavidAnthonyStoltz,MD,PhD University of Iowa Iowa City, IA

Jennifer L. Strande, MD, PhD Medical College of Wisconsin Milwaukee, WI

Tomeka Suber, MD, PhD University of Pittsburgh Medical Center Pittsburgh, PA

Abraham Thomas, MD, MPH NYU Lutheran Brooklyn, NY

Richard R. Watkins, MD, MS, FACP Akron General Medical Center Akron, OH

Neal L. Weintraub, MD Augusta University/Med Coll. Georgia Augusta, GA

Roy E. Weiss, MD, PhD University of Miami Miller School of Medicine Miami, FL

Jing Zhao, MD PhD University of Pittsburgh Pittsburgh, PA

Yutong Zhao, MD, PhD University of Pittsburgh Pittsburgh, PA


About our Featured PresentersMWAFMR Career Development Workshop

Karen R. Horowitz, MD, FACP

Dr.KarenHorowitzisanAssociateProfessor of Medicine in the Division of Clinical and Molecular Endocrinology whose clinical research and teaching activities at UH Case Medical Center and the Louis Stokes Veterans Ad-ministration Medical Center focus on diabetes. She is originator of the UH

CMC Diabetes eCurriculum, an online resource for diabe-teseducationforUHhousestaff.Dr.HorowitzreceivedaScholarship in Teaching Award from the Case SOM for her project, Improving Diabetes Management in the Ambulatory Set-ting. She has been a Co- Investigator for the NIH-sponsored ACCORD Trial and Principal Investigator for the ACCORD MIND Trial for the Ohio-Michigan Network, and continues in these roles in the ACCORDION and RECOVERY-MIND follow up studies. This research focuses on cardiovascular risk reduction in patients with diabetes and on reduction of risks for dementia in patients with diabetes. Other interests include management of diabetes in pregnancy and use of continuous glucose monitors in clinical practice.

Dr.HorowitzisagraduateoftheStateUniversityofNewYork at Buffalo School of Medicine and the University of Rochester Associated Hospitals Program in Internal Medicine. She is Board Certified in Internal Medicine and a Fellow of the American College of Physicians, as well as a member of the American Diabetes Association and the Endocrine Society. She is a Trustee of the Diabetes Associ-ation of Greater Cleveland where she serves as a member of the Executive Steering Committee, Camp Ho Mita Koda Medical Staff, and Chair of the Camp Steering Committee.

Amir K. Jaffer, MD, MBA

Amir K. Jaffer, MD, MBA, SFHM is Professor of Medicine, Associate Chief Medical Officer, and the Vice Chair, Quality and Patient Safety in the Department of Medicine at Rush University Medical Center in Chicago, IL. As the Division Chief of the newly formed Division of Hospital Medicine

at Rush, Dr. Jaffer has led several initiatives in improving case management, reducing length of stay, and improv-ing patient satisfaction. As the Vice Chair for Quality and Patient Safety, he established a robust infrastructure for patient safety and quality improvement in the Department of Internal Medicine. He is passionate about improving care and systems in the hospital.

Dr. Jaffer received his medical degree from Boston Univer-sity School of Medicine in 1994. His postgraduate training included an internship and residency in internal medi-

cine at Yale New Haven Hospital in New Haven, CT. He is board-certified in Internal Medicine and practices both Hospital and Perioperative Medicine. He also completed an MBA in Healthcare Management and Policy at the Uni-versity Of Miami School Of Business. He has been selected as one of the Best Doctors in America for the last seven years by Best Doctors.

Max Miller LectureRaghavendra G. Mirmira, MD, PhD

Dr. Raghu Mirmira received his bach-elor’s, MD, and PhD degrees from the University of Chicago. His interest in diabetes began in his PhD years, during which time he studied how insulin binds to cells to effect its actions. His PhDdissertationwasrecognizedasoneof the four best dissertations submitted

throughout the entire institution, earning him the Marc Perry Galler Award.

Dr. Mirmira completed his residency in Medicine and subspecialty training in Diabetes and Endocrinology at the University of California at San Francisco. He received the prestigious Physician Postdoctoral Fellowship Award from the Howard Hughes Medical Institute, and later a Research Career Award from the National Institutes of Health.

Dr. Mirmira joined the faculty at the University of Vir-ginia in 2000 and is currently the Eli Lilly & Co. Chair in Pediatric Diabetes and Director of the Pediatric Diabetes Research Group at Indiana University in Indianapolis. He is the Director of the Center for Diabetes and Metabolic Diseases (recently funded in part by a P30 award from the National Institutes of Health), and is also Director of the NIH-funded Medical Scientist Training Program (MD-PhD program). Dr. Mirmira serves as a member of the Diabetes, Endocrinology and Metabolic Diseases B Subcommittee of the Diabetes and Digestive and Kidney Diseases Initial Review Group, National Institute of Diabe-tes and Digestive and Kidney Diseases, National Institute of Health.


AFMR KeynoteMichael G. Ison, MD

Michael G. Ison, MD, was born in St. Petersburg, Florida. He attended Grinnell College in Iowa where we received his Bachelor of Arts degree in Chemistry and Chinese Studies before returning to Florida where he obtained his medical degree at the University of South Florida College of Medicine. He

completed his Internal Medicine residency and General Internal Medicine Fellowship at Oregon Health Sciences University in Portland. He then obtained his Master of Science in Health Evaluation Sciences and completed a fellowship in infectious diseases at the University of Virginia. He undertook additional training in Transplant Infectious Diseases at the Massachusetts General Hospital and Harvard Medical School under the mentorship of Jay A. Fishman, MD.

Dr. Ison then joined the faculty of the Divisions of Infec-tious Diseases and Organ Transplantation at Northwestern University Feinberg School of Medicine in 2005. He is currently the Medical Director of the Transplant & Immu-nocompromised Host Infectious Diseases Service at the Northwestern University Comprehensive Transplant Center.

Department Chair Session IAnne Joseph, MD, MPH Presiding

Dr. Joseph is a Wexler Professor of Medicine and general internist in the Department of Medicine. She received her medical training at the University of Michigan and received a Masters of Public Health in Epidemiology from the University of Minnesota. She is cur-rently directing the Applied Clinical Re-

search Program in the Department of Medicine. Her pri-mary research interests are in tobacco control. Her work has focused on smoking cessation and smoking reduction interventions for special populations of smokers that ex-perience unique barriers to delivery of tobacco treatment. Dr. Joseph is past president of the Society for Research on Nicotine and Tobacco, Co-Chair of the Medical School Promotion and Tenure Committee and a member of the University of Minnesota Women’s Faculty Cabinet.

Paul Drawz, MD

PaulDrawzattendedmedicalschoolatthe University of Minnesota. He com-pleted his residency and nephrology fel-lowship training at Case Western Reserve University. His clinical research focuses on the relationship between kidney function, ambulatory BP, and adverse cardiovascular and renal outcomes.

Emil Lou, MD, PhD, FACP

After completing undergraduate stud-ies in biochemistry at SUNY College at Geneseo, Dr. Lou received his MD and PhD degrees (Microbiology and Immu-nology) from SUNY Upstate Medical University in 2004. He performed his residency training in Internal Medicine at Duke University Medical Center and

then completed his Medical Oncology and Hematology fellowship at the Memorial Sloan-Kettering Cancer Center in 2010. He also completed an additional fellowship in Neuro-oncology at the Preston Robert Tisch Brain Tumor Center at Duke.

Dr. Lou, a diplomat of the American Board of Internal Medicine, is board certified in Medical Oncology, Internal Medicine, and Neuro-oncology. He joined the faculty in the Division of Hematology, Oncology and Transplanta-tion at the University of Minnesota in 2011, and is also a Graduate Program Faculty Member in the Integrative Biology and Physiology (IBP) Program.

Julie H. Ostrander, PhD

Dr. Ostrander earned her PhD from the University of North Carolina - Chapel Hill in Genetics and Molecular Biology. She held postdoctoral positions at the University of Minnesota and Duke Uni-versity. Her graduate and postdoctoral studies focused on cancer cell signaling mechanisms. Current research is fo-

cused on understanding altered cellular signaling during breast cancer initiation. Her goal is to identify tissue bio-markers that can be used to identify women at high risk for developing breast cancer who could be subjects for novel chemoprevention strategies.

About our Featured Presenters


Department Chair Session IIMark W. Geraci, MD Presiding

Mark Geraci was born and raised in Cincinnati, OH. He completed his un-dergraduate training at the University of Colorado, Boulder. Following grad-uation from the Johns Hopkins Univer-sity School of Medicine, he completed training in Internal Medicine at the Massachusetts General Hospital. After

training in Pulmonary Diseases and Critical Care Medi-cine at the University of Colorado he remained as faculty, eventually to Head the Pulmonary Division. He is current-ly the John B. Hickam Professor and Chair of Medicine at Indiana University.

Dr. Geraci is a tremendous contributor to medical edu-cation, and has served as President of the Association of Specialty Professors for the Alliance of Academic Internal Medicine, and as a member of their Education Committee.

Catherine Rufatto Sears, MD

Dr. Sears graduated from Indiana University School of Medicine and com-pleted an Internal Medicine residency at Vanderbilt University. She trained as a Pulmonary and Critical Care fellow at Indiana University School of Medicine and during that time, developed an interest cigarette-smoke-induced lung

disease with a particular interest in lung cancer. Dr. Sears trained in the laboratory of Dr. John Turchi, an expert in the role of DNA repair in lung cancer treatment response, and was recruited to continue her research at Indiana University as a junior faculty. This collaboration has been successful, resulting in additional funding and publica-tions which have further defined the mechanistic role of DNA repair processes on cancer cell response to chemo-therapy and radiation treatment, leading to the testing and development of small molecular inhibitors which can augment lung cancer response to chemotherapeutic and radiation treatments.

Dr. Sears is a clinician scientist, and the majority of her clinical time is spent staffing a pulmonary oncology clinic. In addition, Dr. Sears is investigating the impact of DNA repair on smoking-induced lung disease and early lung cancer development and was recently awarded a Men-tored Research Scholars Grant from the American Cancer Society to study the impact of the DNA repair protein, XPC, on smoking-induced lung cancer development. She is presenting some early data from this project today.

Tuan M. Tran, MD, PhD

Tuan Tran graduated from Emory University’s Medical Scientist Training Program, where he studied the human immune response to Plasmodium vivax in individuals naturally exposed to ma-laria. After finishing Internal Medicine residency at Johns Hopkins Hospital, he completed a clinical infectious dis-eases and malaria research fellowship.

Dr. Tran’s research interests cover many facets of both naturally acquired and vaccine-induced immunity to Plas-modium falciparum in humans, including using systems biology approaches to gain insight on mechanisms that may be protective against P. falciparum infection and/or malaria disease.

Kathleen T. Unroe, MD

Kathleen Unroe, MD, MHA, is an Assistant Professor of Medicine at Indiana University in Indianapolis and a Research Scientist with IU Center for Aging Research and Regenstrief Institute. She is a nursing home physi-cian – her research, clinical, and policy interests are focused on improving

quality of care, particularly access to palliative and end-of-life care, for long stay nursing home residents. Dr. Unroe was awarded a 2014 Paul B. Beeson K23 Career Development Award to examine hospice use in nursing homes. She is the co-project director of OPTIMISTIC, a 4-year, $13.4 million CMS-funded demonstration project aimed at improving quality of care and reducing avoidable hospitalizationsin19Indiananursinghomes,andisthePrincipal Investigator of a Hartford Foundation planning grant focused on OPTIMISTIC dissemination.

Dr. Unroe has also been funded by the National Pallia-tive Care Research Center and was the American Acad-emy of Hospice and Palliative Medicine 2014 Junior Investigator of the Year. She is Vice-Chair of the Amer-ican Geriatrics Society Public Policy Committee. She is Chair of the American Academy of Hospice and Pallia-tive Medicine Research Committee. She was a 2009-2010 Health and Aging Policy Fellow and had a placement in Health and Human Services, ASPE Office of Disability, Aging, and Long Term Care Policy. She is a Board Mem-ber of the Indiana Medical Directors Association and the Indiana Health Care Foundation.



John B. Hickam LecturerDavid O. Meltzer, MD, PhD

DavidMeltzer,MD,PhD,isChiefoftheSection of Hospital Medicine, Director of the Center for Health and the Social Sciences and the UChicago Urban Health Lab, and Chair of the Com-mittee on Clinical and Translational Science at the University of Chicago, whereheisTheFannieL.PritzkerPro-

fessor in the Department of Medicine, the Harris School of Public Policy Studies, and the Department of Econom-ics.Dr.Meltzer’sresearchexploresproblemsinhealtheconomics and public policy with a focus on the theoreti-cal foundations of medical cost-effectiveness analysis and the cost and quality of hospital care.

He currently leads a CMMI Challenge award to study the effects of improved continuity in the doctor-patient rela-tionship between the inpatient and outpatient setting on thecostsandoutcomesofcareforfrequentlyhospitalizedMedicare patients. He helped lead the CTSA-funded Chi-cago Learning Effectiveness Advancement Research Net-work (Chicago LEARN) and the PCORI-funded Chicago Area Patient Centered Outcomes Research Network (CAP-riCORN).MeltzercompletedhisMDandPhDineco-nomics at the University of Chicago and his residency in internal medicine at Brigham and Women’s Hospital. His awards include the Garfield Award from Research Ameri-ca, the AHRQ Eisenberg Excellence in Mentoring Award, and the AAMC Learning Healthcare System Award. He is a member of the National Academy of Medicine.


S av e t h e D a t e

2017 Combined annual Meeting of CSCtR and MWaFMR

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