filtration, separation & purification solutions for biopharma...

Filtration, Separation & Purification Solutions for Biopharma Applications

- 1 - - 2 -

Filter Manufacturing

Membrane Manufacturing

Validation Center

Depth Filtration

Sterilizing-Grade Filters

Redundant Filters

Endotoxins Removal Filters

Gamma Irradiation Filters

Ultrafiltration Product

Stainless Steel Filters

System Design(Sterilizing Filtration/CIP System/UFF System...)

Mycoplasma Removal Filters

Validation Services

Filtration, Separation & PurificationSolutions for Biopharma Applications

Filtration, Separation & Puri�cationSolutions for Biopharma Applications

Monoclonal Antibodies

Recombinant Protein

Gene-based Medicine

Blood Product

Probiotics

Vaccines

Penicillin-streptomycin

ApplicationC1 FactoryMembrane Filter Manufacturing9400 SQM

C2 Factory Depth Filter Manufacturing9000 SQM

C3 Factory Semiconductor Products Manufacturring13600 SQM, 2019

C4 Factory Sustainless Filter Manufacturing& Fluoroplastics Resurtech Manufacturing& Housing Manufacturing28000 SQM

C5 Lab R&D, Lab Center41000 SQM, 2020

C6 Factory Life Center25000 SQM

C3C2

C4

C6

C1C5

Cobetter dedicates itself to providing Filtration, Separation, & Purification

Solutions across all industries.Cobetter provides over 1,200+ technical analysis reports annually

for customers in the pharmaceutical industry and over 1,300+ technical analysis reports annually

for customers in chemical, microelectronics and life sciences industries

Housing Manufacturing

50+ Equipments

180+ SOP

80+ EngineersCover all the Validation Tests

ilac-MRA

ISO 17025

Validation Center

Quality

Manufacturing

Product

Cost Delivery

4M Manufacture

3 Elements of the Products

Man MethodMaterial Machine

Accredited by China National Accreditation Service for Conformity (CNAS)Established with an initial 10milllion USD investment

1 2

3

4

5

6

61

4

5

2

3

Bacterial Challenge Test : Retention tests for Mycoplasma, B.diminuta, Serratia marcescens, lactobacillus, saccharomycetes, colibacillus and other microorganismsChemical Analysis : Extractable & Leachables , Chemical Compatibility testUV/PDA-HPLC : UV/PDA scanning to determine extractables and leachablesUPLC/MS : Determine the nonvolatile and semivolatile of extractable & leachables quantitatively and qualitativelyGC-MS : Determine volatile/semi-volatile status of extractables and leachables quantitatively and qualitativelyIC/ICP-MS : Analyze alkalis, halogen family, acid radicals, ammonia, and other ions quantitatively NVR : Analyze non-volatile extractable from water, IPA, Acetone and other volatile solutions quantitativelyFTIR : Analyze polymers and oligiomers in non-volatile extractable & leachables qualitativelySEM/EDS : Analyze filter membrane defect, appearance, and impurities. SEM analysis of chemical compatibility

Life & Science Validation Center

Advanced Japanese Quality Control MethodsEnsure that Every Product is Safe, Reliable, and Stable

Quality Assurance is based on the Quality Assurance System - Focus on the Production Process

Implement 4M Quality Management Concept - Process and System Simultaneous Completion

All Products are based on the QC Project Table - Produced as per SOP for Stable Production

Previous Pall Lab Expert for More Than 30 Years.

Taketomi Hidetoshi, Japanese

- 5 - - 6 -Filtration, Separation & Purification

Solutions for Biopharma ApplicationsFiltration, Separation & Puri�cationSolutions for Biopharma Applications

Flow Diagram of Bioprocess

Media Filtration1 2

3

62 Gas Filtration

Clarification

Column/TFFProtection

Buffer Filtration

Buffer Filtration

Sterile Vent

Fermentation/Bioreactor

Concentration

4

Buffer FiltrationBuffer Filtration

33 3

3

6

5

8

9

Concentration and Diafiltration

Virus Removal Filtration

7 Virus Removal Pre-filtration

Column Protection

Affinity Chromatography

Polishing Chromatography

Buffer Filtration

Buffer Filtration

DiafiltrationBuffer Filtration

Sterile Filtration

Virus InactivationPurificationChromatography

Filling

Centrifugation

Tangential FlowMicrofiltration

5

3



1

-Purcise® SLE -Double Layer PES-Purcise® SPS -PES-Corevital® SND -Double Layer PVDF -Corevital® SMD -PVDF

Media Filtration

Bioburden Reduction and Particle Control-Greclary® CHV -Glass Fiber-Safetect® PME -PES-Purcise® PLE -Double Layer PES

Sterilizing-grade Filtration

-Purcise® MLE -Double Layer PESMycoplasma Removal

4 Clarification Filtration

-Roheap® CSD 2 Vent and Gas Filtration

-Aegivast® AFL -Hydrophobic PTFE-SafesureTM AFM -Hydrophobic PTFE-Aegivast® ACE -Hydrophobic PTFE-Corevital® APB -Hydrophobic PVDF

3 Buffer Filtration

-Purcise® PLE -Double Layer PES-Purcise® PAF -PES-Safetect® PME -PES-Corevital® SAF -Double Layer PES-Purcise® SLE -Double Layer PES-Purcise® SPS -PES-Corevital® SND -Double Layer PVDF-Corevital® SMD -PVDF

5 Column / TFF Protection

Bioburden Reduction and Particle Control-Purcise® PLE -Double Layer PES-Safetect® PME -PES-Corevital® PND -Double Layer PVDF

Clarification -Greclary® CHV -Glass Fiber-Excesal® CHE -PP-Excesal® CHC -PP-Excesal® CHT -PP

Sterilizing-grade Filtration-Purcise® SLE -Double Layer PES-Corevital® SND -Double Layer PVDF

6 Concentration and Purification

-Consieve® UET -PES

-Purcise® SLE -Double Layer PES-Purcise® SPS -PES-Corevital® SND -Double Layer PVDF

9 Sterile Filtration

8 Virus Clearance

-Viruclear® -PES* * Being Developed

7 Viral Remove Prefiltration

-Purcise® SLE -Double Layer PES-Purcise® SPS -PES-Corevital® SND -Double Layer PVDF -Purcise® MLE -Double Layer PES

Bricap & Brisip Capsule Filter SeriesInlet /Outlet Connections

14 mm (9/16") Sanitary Flange

FS

31 mm (1 1/4") Sanitary Flange 38 mm (1 1/2") Sanitary Flange

Y

H

V

X

M

D

B

E

S-S

9.6 mm (3/8") Single Stepped Hose Barb

13 mm (1/2") Single Stepped Hose Barb




25 mm (1") Single Stepped Hose Barb

6-13 mm (1/4"-1/2") Multiple Stepped Hose barb

6-9 mm (1/4"-3/8") Multiple Stepped Hose barb

38 mm (1 1/2") Sanitary Flange(Only for T -Type Capsule)

K

C

P

19 mm (3/4") Sanitary FlangeT

Cartridge Filters

Nominal Length

5"10"20"30"40"

Adaptor Seal Material

SiliconeEPDMVitonTEV

226/Fin226/Flat222/Fin222/FlatDouble Open End

Female Luer Lok™ Inlet

Male Luer Lok™ Outlet



Item

Bricap® V50D

Bricap® V50A

Bricap® V42

BriScale® A50

Diameter Max. Length Inlet/Outlet Vent

70mm

74mm

47mm

71mm

N/A

N/A

N/A

Luer lock

64mm

73mm

56mm

64mm

6-13 mm (1/4"-1/2") Stepped Hose Barb

6-9 mm (1/4"-3/8") Stepped Hose Barb

6-13mm(1/4''-1/2'') Stepped Hose Barb

Item

Bricap® C01

Bricap® C02

Bricap® C03

Diameter Max. Length Inlet/Outlet Vent/Drain

106mm

136mm

173mm

64mm 6mm Hose Barb

14 mm (9/16") Sanitary Flange19 mm (3/4") Sanitary flange31 mm (1 1/4") Sanitary Flange6-13 mm (1/4"-1/2") Stepped Hose Barb9.6mm (3/8") Hose Barb

Item

Brisip® SP3


159mm81mm 6mm Hose BarbStäubli38 mm (1 1/2") Sanitary Flange

Item

Bricap® T10

Bricap® T20

Bricap® T30


354mm

592mm

845mm

89mm

/152mm6mm Hose Barb

Gauge Port

14 mm (9/16") Sanitary Flange38 mm (1 1/2") Sanitary FlangeNo top port

Bricap®/BriScale® Disc Capsule Filters

Bricap® C/D Series Capsule Filters

Brisip® Series Capsule Filters

Bricap® T Series Capsule Filters

Bricap® L Series Capsule FiltersItem

Bricap® L03

Bricap® L05

Bricap® L10

Bricap® L20

Bricap® L30


190mm

233mm

347mm

585mm

838mm

89mm 6mm Hose Barb

14 mm (9/16") Sanitary Flange19 mm (3/4") Sanitary flange38 mm (1 1/2") Sanitary Flange13 mm (1/2") Hose Barb14 mm (9/16") Hose Barb16 mm (5/8") Hose Barb19 mm (3/4") Hose Barb25 mm (1") Hose Barb

38 mm (1 1/2") Sanitary Flange 19mm (3/4” )Sanitary Flange(Inlet/Outlet)

Clarification Filter Series

Pre-filtration and Redundant Filter Series

Sterile-Grade Filter Series

Other Products

Mycoplasma Removal Filter Series

Gas Filtration Filter Series

Purcise SAF FilterHydrophilic Sterile-Grade Filter with High Flow Rates

TFF Cassettes /Stainless Holder /System

Integrity Test Instrument

Clean Steam Bag

Vacccum Filter

Filter Housing

Purcise PAFHydrophilic Sterile-Grade Filter with High Flow Rates

Purcise PLE FilterHydrophilic Filter with Low Extractables

Purcise SLE FilterHydrophilic Sterile-Grade Filter with Low Extractables

Corevital PND Hydrophilic Sterile-Grade Filter with Low Protein Binding

Corevital PMD Low Protein Binding and Hydrophilic Filter

Greclary CHV FilterHigh Dirt Holding Capacity and Retention Efficiency

Purcise SPS FilterHydrophilic Sterile-Grade Steam-in-Place (SIP) Filter

Corevital SND FilterHydrophilic Sterile-Grade Filter with High Flow Rates

Corevital SMD FilterHigh Flow Rate, Low Protein Binding Hydrophilic Sterile Filter

Apexision® SBC FilterHydrophilic Sterile-Grade Filters with Large EFA

Purcise MLE FilterHydrophilic Filter with Low Extractables

Aegivast AFL FilterHydrophobic Filter with High Retention Rates

Aegivast ACE FilterHydrophobic Filter with High Retention Rates

Safesure AFM FilterHydrophobic Filter with High Retention Rates

Corevital APB FilterGamma-resistant Hydrophobic Filter

Excesal® CHCHigh Dirt Holding Capacity

Excesal CHTHigh Dirt Holding

Excesal® CHE

High Retention Efficiency

P 10

P 12

P 14

P 16

P 17

P 23

P 24

P 27

P 28

P 31 P 39

P 41

P 41

P 41

P 42

P 19

P 25

P 33

P 34

P 35

P 37

P 20

P 21

P 22

P 29

Catalog

- 10 -Filtration, Separation & Purification


B Series DSeries ppb0.7553.861.48

0.0823.28

ppb----

Explanation：- means < 0.05ppb


Roheap® CSD FilterHigh Dirt Holding Capacity

Roheap® CSD FilterHigh Dirt Holding Capacity

Features

Applications

Filter Material

Operating Conditions

Filter Media Cellulose diatomite filter aid and ionic wet-strength resin

· Clarification of fermentation broth/cell cultures· Filtration of blood and blood products· Filtration of enzyme preparation· Filtration of colloids/viscous liquids

Diffe

rent

ial P

ress

ure

(bar

)

Flow Rate ( L /min /m2 )

0040

0100

0500

1.2

1

0.8

0.6

0.4

0.2

010 20 30 40 50

ChemicalsNaOHHClHNO3

H2SO4

Acetic acid Citric acid Peracetic acid Butanol Ethanol

Concentration2%5%5%10%38%10%0.1%80%80%

@20°CGGGGGGGGG

IonMgAlCaCrFe

ppb0.735.335.650.07113.1

IonNiCuAsPb

IonMgAlCaCrFe

IonNiCuAsPb

ppb-

0.1620.987

-

@80°CPPPPGGGGG

Chemical Compatibility

Leachables

80°C0.24 MPaFlushing volume 50L/m², Flow Rate 10L/min/m²

Biological Safety

EndotoxinsBio-compatibility

· Filter media composed of lignocellulose and inorganic filter aids· Gradient filter structure provides high dirt holding capacity and

retention efficiency· Low initial pressure difference and long service life· Positive Zeta charge results in removal efficiency for host DNA, HCP, etc.

Max. Temperature Max. Differential PressureRinse

<0.25 EU/mlMeet the requirement of USP<87> In Vitro Cytotoxicity Test;Meet the criteria of the USP<88> Biological Reactivity Test for Class VI-121°C plastics

G = Recommended ; P = Not recommended

- 9-

Sterilization Capability Bricap C、 Bricap L、 Bricap T Series and Filter Cartridges: Autoclave


Max. Temperature Max. Differential Pressure

80°C0.55 MPa / 25°C0.1 MPa / 80°C

Filter TypeMembraneCore/Cage/End CapCapsule ShellO-ringCapsule Vent O-ringRemoval Ratings

Bricap C/L/TGlass Microfiber (GF) Polypropylene (PP)Polypropylene (PP)⸺Silicone0.2/0.45/0.8/1.0/3.0/5.0μm

Cartridge Glass Microfiber (GF) Polypropylene (PP)⸺Silicone/EPDM/Viton/PTFE⸺

Materials of Construction

Diffe

rent

ial P

ress

ure

kPa 10

8

6

4

2

0

0 10 20 30 40 50

0.2

0.45

1.0

Flow Rate @ 20°C (L/min)

·

Water Flow Rate - Cobetter Greclary CHV 10″ Cartridge Features

Applications· Pre-filtration of cell culture medium· Clarification of fermentation broth/cell cultures· Filtration blood products/serums· Filtration of colloids/viscous liquids

· Composed of super-fine glass fiber media· Rigid fiber material which is suitable for colloid filtration· High dirt holding capacity and retention efficiency· Low initial pressure, high flow rates and long service life

Biological Safety




Greclary CHV FilterHigh Dirt Holding Capacity and Retention Efficiency



Effective Filtration Area

Bricap CC01: 80cm2

C02: 200cm2

C03: 300cm2

Bricap LL03: 0.07m2

L05: 0.12m2

L10: 0.24m2

L20: 0.48m2

L30: 0.72m2

Bricap TT10: 0.24m2

T20: 0.48m2

T30: 0.72m2

Cartridge 5"10"20"30"40"

: 0.12m2

: 0.24m2

: 0.48m2

: 0.72m2

: 0.96m2

CSD Lenticular Filter Series

Seal Material

CSD

Removal Ratings Control Grade

Pharma GradePBPCPDPE

Standard GradeSA

WYGBNXQTFD

12 inch16 inch

Number of Lenses

234591011121516

P PharmaceuticalSEVTF

SiliconeEPDMVitonSoft PTFEHard PTFE

Diameter

1216

Number of LayersSingle-Layer

PC S D

DOE

End CapDouble Open End

D O E

Removal Ratings Control Grade

Pharma GradePBPCPDPE

Standard GradeSA

Filter Name

P Pharmaceutical

PC D F

Filter Media

C S DC

CSDD

S

Number of Layers

Single-Layer

Double-Layer

D Double-Layer

000400200040006001000150030004000500060007000800

0.04-0.2μm0.2-0.4μm0.4-0.6μm0.6-0.8μm0.8-1.5μm1.5-3.0μm3.0-6.0μm4.0-9.0μm5.0-12.0μm6.0-15.0μm7.0-18.0μm8.0-20.0μm

0102010601400180028006801080

0.04-0.4μm0.04-0.8μm0.04-9.0μm0.04-20.0μm0.2-20.0μm0.6-20.0μm0.8-20.0μm

000400200040006001000150030004000500060007000800

0.04-0.2μm0.2-0.4μm0.4-0.6μm0.6-0.8μm0.8-1.5μm1.5-3.0μm3.0-6.0μm4.0-9.0μm5.0-12.0μm6.0-15.0μm7.0-18.0μm8.0-20.0μm

0102010601400180028006801080

0.04-0.4μm0.04-0.8μm0.04-9.0μm0.04-20.0μm0.2-20.0μm0.6-20.0μm0.8-20.0μm



Greclary Series Part Number Configuator (GF)Capsule Filter Example : C01TTCHV02A1P Bricap C Small Capsule Filter Series

Bricap Inline Capsule Filters Series

1 1/2" (38 mm) Sanitary Flange3/4" (19 mm) Sanitary Flange9/16" (14 mm) Sanitary Flange1" (25 mm) Hose Barb3/4" (19 mm) Hose Barb5/8" (16 mm) Hose Barb9/16" (14 mm) Hose Barb1/2" (13 mm) Hose Barb

L03L05L10L20L30

STKDMXVH

Bricap L03Bricap L05Bricap L10Bricap L20Bricap L30

1 1/2" (38 mm) Sanitary Flangewithout Gauge Port

T10T20T30

SN

Bricap T10Bricap T20Bricap T30

Quantity/Package MarketC01C02C03D01

Inlet OutletTA

B

YK

AS

3/4" (19 mm) Sanitary Flange1/4"-1/2" (6-13 mm) Multiple Stepped Hose Barb with Filling Bell (liquids only)1/4"-1/2" (6-13 mm) Multiple Stepped Hose Barb 3/8" (9.6mm) Hose Barb 9/16" (14mm) Sanitary Flange

SterilizationAutoclavableSterile

AS

AutoclavableSterile

AS

AutoclavableSterile

P1 1 / pkgCapsule Formats

Bricap C01Bricap C02Bricap C03Bricap D01

P

Quantity/Package MarketSterilizationP1 1 / pkg

P

Inlet OutletCapsule Formats

Bricap T Capsule

Quantity/Package MarketSterilization

P1 1 / pkg

P


Membrane Type

P

P

Quantity/Package

1 1 / pkg

Cartridge Type

5 inch10 inch20 inch30 inch40 inch

Cartridge Filters

Media O-ring MaterialLength

0510203040

02738

Code

DOE226 / Falt226 / Fin222 / Falt222 / Fin

EVSP

EPDMFluoroelastomerSiliconeFEP/PFA encap-sulated O-rings

A

A Standard CartridgePharmaceutical

Cartridge Filter Example : ACHV02050S1P

Market

CHV02CHV04CHV08CHV10CHV30CHV50

CHV 0.2μmCHV 0.45μmCHV 0.8μmCHV 1.0μmCHV 3.0μmCHV 5.0μm

CHV02CHV04CHV08CHV10CHV30CHV50

CHV 0.2μmCHV 0.45μmCHV 0.8μmCHV 1.0μmCHV 3.0μmCHV 5.0μm


Excesal® CHCHigh Dirt Holding Capacity

Sterilization Capability

Bricap® L、 Bricap® T Series and Filter Cartridges : Autoclave


·

Applications· Pre-filtration of cell culture medium· Clarification of fermentation broth/cell culture· Pre-filtration of blood products/serums· Pre-filtration of colloids/viscous liquids



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety


<0.25 EU/mlMeet USP <87> In Vitro Cytotoxicity Test RequirementsMeet USP <88> Biological Reactivity Test for Class VI-121°C Plastics Requirements


Bricap® C/L/TPolypropylene (PP)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.5/0.6/0.8/1.5/5.0/10/20/40/70/90μm

Cartridge Polypropylene (PP)Polypropylene (PP)⸺Silicone/EPDM/Viton/PTFE⸺


Features

Bricap® C C01: 70cm2

C02: 160cm2

C03: 260cm2

Bricap® LL02: 375cm2

L03: 530cm2

L05: 0.09m2

L10: 0.18m2

L20: 0.36m2

L30: 0.54m2

Bricap® TT10: 0.18m2

T20: 0.36m2

T30: 0.54m2

Cartridge 5"10"20"30"40"

: 0.09m2

: 0.18m2

: 0.36m2

: 0.54m2

: 0.72m2

· Special Winding structure· Composed of multi-layer with increasing accuracy· Long service life · High flow rate

- 13 - - 14 -



BriScale Disc、 Bricap C、 Bricap L、 Bricap T Series and Filter Cartridges: Autoclave·


Excesal CHTHigh Dirt Holding

· Composed of multi-layer Polyproylene media· High retention efficiency· All raw materials meet NSF requirements* No adhesives or surfactants

Applications· Pre-filtration of cell culture medium· Clarification of fermentation broth/cell cultures· Filtration blood products/serums· Filtration of colloids/viscous liquids



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety




Bricap C/L/TPolypropylene (PP)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.5/0.6/0.8/1.0/1.5/5.0/10/20/40/70/90μm



Features




C02: 160cm2

C03: 260cm2

Bricap® LL02: 375cm2

L03: 530cm2

L05: 0.09m2

L10: 0.18m2

L20: 0.36m2

L30: 0.54m2


T20: 0.36m2

T30: 0.54m2

Cartridge 5"10"20"30"40"

: 0.09m2

: 0.18m2

: 0.36m2

: 0.54m2

: 0.72m2

Exceal Series Part Number Configuator (PP)Capsule Filter Example : L03TTCHC05A1PBricap Inline Capsule Filters Series


L03L05L10L20L30

STKDMXVH



T10T20T30

SN


AS

AutoclavableSterile

AS

AutoclavableSterile


P


Bricap T Capsule Filters


P1 1 / pkg

P


Membrane TypeCHC05CHC10CHC30CHC50CHC1X

CHC 0.5μmCHC 1.0μmCHC 3.0μmCHC 5.0μmCHC 10μm

P

P

Quantity/Package

1 1 / pkg

Cartridge Type


Cartridge Filters


0510203040

02738

Code


EVP

EPDMFluoroelastomerFEP/PFA encap-sulated O-rings

A


Market

Cartridge Filter Example : ACHC03050S1P

CHC05CHC10CHC30CHC50CHC1X

CHC 0.5μmCHC 1.0μmCHC 3.0μmCHC 5.0μmCHC 10μm

- 15 - - 16 -

BriScale Disc、 Bricap C、 Bricap L、 Bricap T Series and Filter Cartridges: Autoclave·



Exceal Series Part Number Configuator (PP)Capsule Filter Example : C01TTCHE03A1PBricap C Small Capsule Filter Series



L03L05L10L20L30

STKDMXVH



T10T20T30

SN



Inlet OutletTA

B

YK

AS



AS

AutoclavableSterile

AS

AutoclavableSterile



P


P


Bricap T Capsule Filters


P1 1 / pkg

P


Membrane TypeCHE03CHE06CHE10CHE30CHE50CHT05CHT06CHT08CHT10CHT15CHT50CHT1XCHT2XCHT4XCHT7XCHT9X

CHE 0.3μm CHE 0.65μmCHE 1.0μmCHE 3.0μmCHE 5.0μmCHT 0.5μmCHT 0.6μmCHT 0.8μmCHT 1.0μmCHT 1.5μmCHT 5.0μmCHT 10μmCHT 20μmCHT 40μmCHT 70μmCHT 90μm

P

P

Quantity/Package

1 1 / pkg

Cartridge Type


Cartridge Filters


0510203040

02738

Code


EVP

EPDMFluoroelastomerFEP/PFA encap-sulated O-rings

A


Market

Cartridge Filter Example : ACHE03050S1P

CHT10CHT15CHT50CHT1XCHT2XCHT4XCHT7XCHT9X

CHE03CHE06CHE10CHE30CHE50CHT05CHT06CHT08

CHE 0.3μm CHE 0.65μmCHE 1.0μmCHE 3.0μmCHE 5.0μmCHT 0.5μmCHT 0.6μmCHT 0.8μm

CHT 1.0μmCHT 1.5μmCHT 5.0μmCHT 10μmCHT 20μmCHT 40μmCHT 70μmCHT 90μm

Market

P

PQuantity/Package

AGS

Sterilization

AutoclavableGamma CompatibleSterile

12

1 / pkg2 / pkg

BriScale® Disc Liquid Filter

6-13 mm (1/4"-1/2") Multiple Stepped Hose Barb with Filling Bell (outlet only)6-13 mm (1/4"-1/2") Multiple Stepped Hose Barb (no Filling Bell)

Inlet OutletA

B

Capsule Formats

A 5 0

A50 BriScale® A50


BriScale® Disc、 Bricap® C、 Bricap® L、 Bricap® T Series and Filter Cartridges : Autoclave


·

· Composed of double-layer Polypropylene media· Inner layer uses nanofibers to provide high retention efficiency

Applications· Pre-filtration of cell culture medium· Clarification of fermentation broth/cell cultures· Pre-filtration of blood products/serums· Pre-filtration of colloids/viscous liquids



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety




Bricap® C/L/TPolypropylene (PP)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.3/0.65/1.0/3.0/5.0μm



Features


Excesal® CHE

High Retention Efficiency


C02: 320cm2

C03: 500cm2

Bricap® LL03: 0.1m2

L05: 0.18m2

L10: 0.36m2

L20: 0.72m2

L30: 1.08m2


T20: 0.72m2

T30: 1.08m2

Cartridge 5"10"20"30"40"

BriScale® A25/A50A25: 3.4cm2

A50: 20cm2

: 0.18m2

: 0.36m2

: 0.72m2

: 1.08m2

: 1.44m2

- 18 -- 17 -



Features· Composed of double-layer hydrophilic Polyestersulfone media· Efficient bacteria and particulate retention· Extensive chemical compatibility (pH 1-14)· Low extractables

Applications· Pre-filtration of cell culture medium· Buffer filtration


BriScale Disc、 Bricap C、 Bricap L、 Bricap T : Autoclave (126°C, 60min, 3 times), Gamma irradiation or Pre-sterilizationBricap D : AutoclaveFilter Cartridges: SIP & Autoclave

Diffe

rent

ial P

ress

ure

kPa


150

125

100

75

50

25

00 10 20 30 40 50 60

VV

SV

SD

SS

Water Flow Rate- Cobetter Purcise PLE 0.8+0.45µm Bricap L10 Capsule


Bricap C/D/L/THydrophilic Polyethersulfone (PES)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.8+0.45 μm / 1.0+0.65 μm / 1.5+0.8 μm

Cartridge

Polypropylene (PP)⸺Silicone/EPDM/Viton/PTFE⸺

Material of Construction


·

· ·


Purcise PLE FilterHydrophilic Filter with Low Extractables



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



BriScale A25/A50A25: 3.4cm2

A50: 20cm2

Bricap C/DC01 : 180cm²C02 : 420cm²C03 : 660cm²D01 : 350cm²

Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2


Purcise PAFHydrophilic Sterile-Grade Filter with High Flow Rates

· Efficient bacteria and particulate retention· Extensive chemical compatibility (pH 1-14)· High flow rates

Applications· Sterilize filtration of cell culture medium· Buffer filtration

Features



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety




Bricap C/L/THydrophilic Polyethersulfone (PES)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.45 μm / 1.0 μm

Cartridge






·

· ·


A50: 20cm2


Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

- 19 - - 20 -




Corevital PND Hydrophilic Sterile-Grade Filter with Low Protein Binding



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety




Bricap C/L/THydrophilic Polyethersulfone (PES)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.8+0.45 μm

Cartridge



· Composed of double-layer Polyestersulfone media· Efficient bacteria and particulate retention· Low extractables and protein binding

Applications· Sterilize filtration of cell culture medium· Buffer filtration

Features



·

· ·



A50: 20cm2


Bricap LL02 : 0.12m²L03 : 0.16m²L05 : 0.28m²L10 : 0.55m²L20 : 1.1m²L30 : 1.65m²

Bricap TT10 : 0.55m²T20 : 1.1m²T30 : 1.65m²

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

Features· Efficient bacteria and particulate retention· Extensive chemical compatibility (pH 1-14)· Low extractables

Applications· Sterilize filtration of cell culture medium · Buffer filtration· Pre-column/ultra-filtration protection· Filtration of intermediate products/stock solutions· Filtration of blood products/serums· Sterile filtration of terminal products· Filtration of colloids/viscous liquids

0.2 μm / 0.45+0.2 μm / 0.65+0.2 μm0.8+0.2 μm / 1.2+0.2 μm


150

125

100

75

50

25

00 10 20 30 40 50 60

VVSV

SD

SS

Water Flow Rate- Cobetter Purcise SLE 0.2µm Bricap L10 Capsule


Filter TypeMembraneSupportCore/Cage/End CapCapsule ShellO-ringCapsule Vent O-ringRemoval Ratings

Bricap C/D/L/THydrophilic Polyethersulfone (PES)Polypropylene (PP)Polypropylene (PP)Polypropylene (PP)⸺Silicone

Cartridge

Polypropylene (PP)Polypropylene (PP)——

Silicone/EPDM/Viton/PTFE——


Purcise SLE FilterHydrophilic Sterile-Grade Filter with Low Extractables



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



Diffe

rent

ial P

ress

ure

kPa




·

· ·


A50: 20cm2


Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

- 21 - - 22 -



Features· Efficient bacteria and particulate retention· Extensive chemical compatibility (pH 1-14)· High flow rates

Applications· Sterilize filtration of cell culture medium· Buffer filtration· Pre-column/ultra-filtration protection· Filtration of intermediate products/stock solutions· Filtration of blood products/serums· Sterile filtration of terminal products· Filtration of colloids/viscous liquids



Bricap C/D/L/THydrophilic Polyethersulfone (PES)Polyester (PET)Polypropylene (PP)Polypropylene (PP)——

Silicone

Cartridge

Polypropylene (PP)Polypropylene (PP)Polypropylene (PP)Silicone/EPDM/Viton/PTFE——

0.45+0.2 μm


Sterilization CapabilityBriScale Disc、 Bricap C、 Bricap L、 Bricap T : Autoclave ,Gamma irradiation or Pre-sterilizationBricap D : AutoclaveFilter Cartridges : SIP & Autoclave

·

· ·

125

100

75

50

25

00 1.0 2.0 3.0 4.0 5.0 6.0 7.0 8.0 9.0

KKBB

Water Flow Rate- Purcise SAF 0.2µm Bricap C02 Capsule



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



Diffe

rent

ial P

ress

ure

kPa



Purcise SAF FilterHydrophilic Sterile-Grade Filter with High Flow Rates


A50: 20cm2


Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

Features· Efficient bacteria and particulate retention· Extensive chemical compatibility (pH 1-14)· Low extractables· SIP

Applications· Sterilize filtration of cell culture medium· Buffer filtration· Pre-column/ultra-filtration protection· Filtration of intermediate products/stock solutions· Filtration of blood products/serums· Sterile filtration of terminal products· Filtration of colloids/viscous liquids


Filter TypeMembraneSupportCore/Cage/End CapCapsule ShellCapsule Vent O-ringRemoval RatingsFiltration Area

Brisip SP3Hydrophilic Polyethersulfone (PES)Polypropylene (PP)Polypropylene (PP)Polyetherimide (PEI)Silicone0.2 μm0.15 m²


Brisip SP3 : Autoclave is optional (131°C, 30min, 10 times) ,SIP (135°C, 60 min, 8 times)

150

125

100

75

50

25

00 10 20 30 40 50 60

0.2

·


Purcise SPS FilterHydrophilic Sterile-Grade Steam-in-Place (SIP) Filter



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



Water Flow Rate - Cobetter Purcise SPS 0.2µm Brisip SP3 Capsule

Diffe

rent

ial P

ress

ure

kPa


- 23 - - 24 -



Features· Composed of a double-layer hydrophilic Polyestersulfone (PES) media· Efficient mycoplasma, bacteria and particulate retention· Extensive chemical compatibility (pH 1-14)· Low extractables

Applications· Sterilize filtration of cell culture medium· Pre-column/ultra-filtration protection· Filtration of intermediate products/stock solutions· Filtration of blood products/serums· Sterile filtration of terminal products

BriScale Disc / Bricap C / Bricap L / Bricap T : Autoclave, Gamma Irradiation and Pre-steriliziation optionalBricap D: AutoclaveFilter Cartridges : SIP & Autoclave



Bricap C/D/L/THydrophilic Polyethersulfone (PES)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.2+0.1 μm / 0.45+ 0.1 μm

Cartridge

Polypropylene (PP)——

Silicone/EPDM/Viton/PTFE⸺


·· ·




80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



Mycoplasma Removal Filter Series

Purcise MLE FilterHydrophilic Filter with Low Extractables


A50: 20cm2


Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

Purcise (Liquid) Series Part Number Configuator (PES)Capsule Filter Example : C01TTPLESA1PBricap C Small Capsule Filter Series



L03L05L10L20L30

STKDMXVH


1 1/2" (38 mm) Sanitary Flange3/4" (19 mm) Sanitary Flange9/16" (14 mm) Sanitary Flangewithout Gauge Port

T10T20T30

STKN



Inlet OutletTA

B

YK

AS



AS

AutoclavableSterile

AS

AutoclavableSterile



P


P


Bricap T Capsule


P1 1 / pkg

P

Quantity/Package Market

Market

P1 1 / pkg

P

Inlet Outlet

Inlet Outlet

Capsule Formats

Membrane Type

1 1/2" (38 mm) Sanitary Flange

Brisip Steam-in-Place Capsule Filters

SP3 S PX T

Vent/ Drain6 mm Hose BarbVent Stäubli ConnectorDrain 6 mm Hose BarbStäubli Connector

Capsule Formats

Brisip SP3

PS 3

P

P

Quantity/Package

1 1 / pkg

Cartridge Type


Cartridge Filters


0510203040

02738

Code


EVSP


A


Market

PLESPLEHPLELPAFSPAFPSLENSLESSLEHSLELSLECSAFSSAFHSPSNMLEBMLES

PLE 0.8+0.45μm PLE 1.0+0.65μmPLE 1.5+0.8μmPAF 0.45μm PAF 1.0μm SLE 0.2μmSLE 0.45+0.2μmSLE 0.65+0.2μmSLE 0.8+0.2μmSLE 1.2+0.2μmSAF 0.45+0.2μmSAF 0.65+0.2μmSPS 0.2μmMLE 0.2+0.1μmMLE 0.45+0.1μm

Cartridge Filter Example : APLES050S1P

SPSNMLEBMLES

SLESSLEHSLELSLECSAFSSAFH

PLESPLEHPLELPAFSPAFPSLEN

SPS 0.2μmMLE 0.2+0.1μmMLE 0.45+0.1μm

PLE 0.8+0.45μm PLE 1.0+0.65μmPLE 1.5+0.8μmPAF 0.45μm PAF 1.0μm SLE 0.2μm

SLE 0.45+0.2μmSLE 0.65+0.2μmSLE 0.8+0.2μmSLE 1.2+0.2μmSAF 0.45+0.2μmSAF 0.65+0.2μm

P

PQuantity/Package

AGS

Sterilization


12

1 / pkg2 / pkg



Inlet OutletA

B

Capsule Formats

A 5 0

A50 BriScale® A50

- 25 - - 26 -



Features· Composed of dobule-layer PVDF membrane· Low extractable and protein binding· Efficient bacteria and particulate retention

Applications· Sterilize filtration of cell culture medium· Buffer filtration· Pre-filtration of cell culture medium· Buffer filtration· Pre-column/ultra-filtration protection



Bricap C/D/L/TDouble-Layers Polyvinylidene fluoride (PVDF)Polypropylene (PP)Polypropylene (PP)——

Silicone

Cartridge

Polypropylene (PP)——

Silicone/EPDM/Viton/PTFE——

0.2+0.2 μm

Sterilization CapabilityBriScale Disc、 Bricap C、 Bricap L、 Bricap T : Autoclave (126°C, 60min, 3 times), Gamma irradiation or Pre-sterilizationBricap D : AutoclaveFilter Cartridges : SIP & Autoclave



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety





Corevital SND FilterHydrophilic Sterile-Grade Filter with High Flow Rates

·

· ·


A50: 20cm2


Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

Sterilization CapabilityBriScale Disc、 Bricap C、 Bricap L、 Bricap T : Autoclave (126°C, 60min, 3 times), Gamma irradiation or Pre-sterilizationBricap D : AutoclaveFilter Cartridges : SIP & Autoclave

·

· ·

Sterile-Grade Filters

Corevital SMD FilterHigh Flow Rate, Low Protein Binding Hydrophilic Sterile Filter

Features· High flow rates· Low protein binding· Efficient bacteria and particulate retention

Applications· Sterilize filtration of cell culture medium· Buffer filtration· filtration of cell culture medium· Buffer filtration· Filtration of blood products/serums

· Sterile filtration of intermediate products· Pre-column/ultra-filtration protection· Sterile filtration of terminal products · Filtration of colloids/Viscous liquids


Bricap C/L/TPolyvinylidene fluoride (PVDF)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.2+0.2 μm/0.45+0.2 μm

Cartridge

Polypropylene (PP)——Silicone/EPDM/Viton/PTFE——

Materials of ConstructionOperating Conditions


80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety





A50: 20cm2


Bricap LL02: 0.12m2

L03: 0.16m2

L05: 0.28m2

L10: 0.55m2

L20: 1.1m2

L30: 1.65m2

Bricap TT10: 0.55m2

T20: 1.1m2

T30: 1.65m2

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

- 27 - - 28 -



Market

P

PQuantity/Package

AGS

Sterilization


12

1 / pkg2 / pkg



Inlet OutletA

B

Capsule Formats

A 5 0

A50 BriScale® A50

Corevital (Liquid) Series Part Number Configuator (PVDF)Capsule Filter Example : C01TTSNDBA1PBricap C Small Capsule Filter Series



L03L05L10L20L30

STKDMXVH



T10T20T30

STKN



Inlet OutletTA

B

YK

AS



AS

AutoclavableSterile

AS

AutoclavableSterile



P


P


Bricap T Capsule


P1 1 / pkg

P


Membrane Type

P

P

Quantity/Package

1 1 / pkg

Cartridge Type


Cartridge Filters


0510203040

02738

Code


EVSP


A


Cartridge Filter Example : ASNDB050S1P

Market

PNDSPMDSSNDBSMDNSMDSSMDH

PND 0.8+0.45μmPMD 1.0+0.45μmSND 0.2+0.2μmSMD 0.2μmSMD 0.45+0.2μmSMD 0.65+0.2μm

PNDSPMDSSNDBSMDNSMDSSMDH

PND 0.8+0.45μmPMD 1.0+0.45μmSND 0.2+0.2μmSMD 0.2μmSMD 0.45+0.2μmSMD 0.65+0.2μm


Corevital PMD Low Protein Binding and Hydrophilic Filter



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety




Bricap C/L/TPolyvinylidene fluoride (PVDF)Polypropylene (PP)Polypropylene (PP)⸺Silicone0.8+0.45 μm

Cartridge



Applications· Pre-filtration of cell culture medium· Buffer filtration· Pre-filtration of terminal products· Pre-column/ultra-filtration protection

· Composed of dobule-layer PES membrane· Extensive chemical compatibility· High dirt holding capacity

Features



·

· ·



A50: 20cm2



Bricap TT10 : 0.55m²T20 : 1.1m²T30 : 1.65m²

Cartridge 5"10"20"30"40"

: 0.28m2

: 0.55m2

: 1.1m2

: 1.65m2

: 2.2m2

- 29 - - 30 -



Sterile-Grade Filters

Apexision® SBC FilterHydrophilic Sterile-Grade Filters with Large EFA

Features· Composed of a unique double-layer Nylon 66 membrane· Inherently hydrophilic· Efficient bacteria and particulate retention· Excellent chemical compatibility

Applications· Buffer filtration· Filtration of intermediate products/stock solutions· Sterile filtration of terminal products

Sterilization CapabilityBriScale® Disc、 Bricap® C、 Bricap® L、 Bricap® T : Autoclave, Gamma Irradiation and Pre-steriliziation optionalFilter Cartridges : SIP & Autoclave


Bricap® C/L/TNylon66Polypropylene (PP)Polypropylene (PP)⸺Silicone0.2+0.2 μm/0.45+0.2 μm

Cartridge Nylon66Polypropylene (PP)——Silicone/EPDM/Viton/PTFE——



BriScale® A25/A50A25: 3.4cm2

A50: 20cm2

Bricap® C C01C02C03

Bricap® LL03L05L10L20L30

Bricap® TT10T20T30

Cartridge 5”10”20”30”40”

··



80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



Apexision Series Part Number Configuator (Nylon 66)Capsule Filter Example : C01TTSBCA1PBricap C Small Capsule Filter Series



L03L05L10L20L30

STKDMXVH


T10T20T30



Inlet OutletTA

B

YK

AS

3/4" (19 mm) Sanitary Flange1/4"-1/2" (6-13 mm) Multiple Stepped Hose Barb with Filling Bell (liquids only)1/4"-1/2" (6-13 mm) Multiple Stepped Hose Barb 3/8" (9.6mm) Hose Barb9/16" (14 mm) Sanitary Flange


AS

AutoclavableSterile

AS

AutoclavableSterile



P


P


Bricap T Capsule


P1 1 / pkg

P


Membrane Type

Cartridge Filters

SBC SBC 0.45+0.2μm

Cartridge Filter Example : ASBC050S1P

P

P

Quantity/Package

1 1 / pkg

Cartridge Type



0510203040

02738

Code


EVSP


A


Market

SBC SBC 0.45+0.2μm


STKN

Market

P

PQuantity/Package

AGS

Sterilization


12

1 / pkg2 / pkg



Inlet OutletA

B

Capsule Formats

A 5 0

A50 BriScale® A50

- 31 - - 32 -



Features· Inherently hydrophobic membrane· High retention rates· Low pressure differential· Efficient mycoplasma, bacteria and particulate retention

Applications

0.2 μm

· Vent Filters for fermentors, tanks, etc. · Sterile-grade filtration for air, oxygen, nitrogen, etc.


Bricap L/T

Polypropylene (PP)Polypropylene (PP)Polypropylene (PP)——Silicone

Brisip SP3

Polypropylene (PP)Polypropylene (PP)PEI polyetherimide (PEI)SiliconeSilicone

Cartridge

Polypropylene (PP)Polypropylene (PP)——Silicone——

8.0

6.0

4.0

2.0

00 50 100 150 200 250

VV

SS

Air Flow Rate - Cobetter Aegivast AFL Bricap L03 Capsule

· Bricap L 、 Bricap T : Autoclave· Brisip SP3、 Filter Cartridge : Autoclave & SIP




80°C0.55 MPa / 25°C0.1 MPa / 80°C


Bricap LL03 : 0.2m²L05 : 0.34m²L10 : 0.68m²L20 : 1.36m²L30 : 2.04m²

Bricap TT10 : 0.68m²T20 : 1.36m²T30 : 2.04m²

Brisip SP30.2m²

Cartridge 5”10”20”30”40”

Biological Safety





Aegivast AFL FilterHydrophobic Filter with High Retention Rates

Hydrophobic Polytetrafluoroethylene (PTFE)

Differential Pressure (kPa)

Air Flow Rate @ 20°C (L/min)

Biological Safety




Aegivast ACE FilterHydrophobic Filter with High Retention Rates

Features· High retention rates· Low pressure differential· Efficient mycoplasma, bacteria and particulate retention

Applications· Vent Filters for fermentors, tanks, etc. · Sterile-grade filtration for compressed air, oxygen, nitrogen, etc.




Bricap SFU13 / SFU25 / SFU33 Disc : Autoclave, Gamma Irradiation or Pre-sterilization optionalBricap V42/V50A/V50D Disc: Autoclave (130°C, 30min, 20 times), Gamma irradiation or Pre-sterilization

TypeMembraneSupport layerCore/Cage /End capCapsule shell

Bricap SFU13 / SFU25 / SFU33Hydrophobic polytetrafluoroethylene(PTFE)Polyester (PET)Polypropylene(PP)

Bricap V42 / V50A / V50DHydrophobic polytetrafluoroethylene(PTFE) Polyester or Polypropylene(PET/PP) Polypropylene(PP)

0.2 μm

Differential Pressure (kPa)Differential Pressure (kPa)


40

30

20

10

00 0.5 1.0 2.0 2.5 3.0 3.51.5 4.0

SFU13

SFU25 SFU33

Air Flow Rate - Cobetter Aegivast ACE Bricap SFU Series Disc Filter


80

60

40

20

00 5.0 10.0 20.0 25.0 30.0 35.015.0 40.0

V42

V50A

V50D

Air Flow Rate - Cobetter Aegivast ACE Bricap V Series Disc Filter


Max Operating TemperatureMax Differential Pressure

50°C0.24 MPa / 25°C 0.42 MPa / 25°C (noly for V50D)

Bricap SFUSFU13 : 0.72cm2

SFU25 : 3.4cm2

SFU33 : 4.5cm2

Bricap VV42 : 13.8cm2

V50A : 20cm2

V50D : 20cm2

··

- 33 - - 34 -



Features· Inherently hydrophobic membrane· High retention rates· Low pressure differential· Efficient mycoplasma, bacteria and particulate retention

Applications

0.2 μm

· Vent Filters for fermentors, tanks, etc. · Sterile-grade filtration for air, oxygen, nitrogen, etc.


Bricap L/T

Polypropylene (PP)Polypropylene (PP)Polypropylene (PP)——Silicone

Brisip SP3

Polypropylene (PP)Polypropylene (PP)PEI polyetherimide (PEI)SiliconeSilicone

Cartridge

Polypropylene (PP)Polypropylene (PP)——Silicone——

8.0

6.0

4.0

2.0

00 50 100 150 200 250

VV

SS

Air Flow Rate - Cobetter Aegivast AFM Bricap L03 Capsule

· Bricap L 、 Bricap T : Autoclave· Brisip SP3、 Filter Cartridge : Autoclave & SIP




80°C0.55 MPa / 25°C0.1 MPa / 80°C


Biological Safety





SafesureTM AFM FilterHydrophobic Filter with High Retention Rates

Hydrophobic Polytetrafluoroethylene (PTFE)




Bricap CC01 : 200cm²C02 : 480cm²C03 : 750cm²

Bricap TT10 : 0.68m²T20 : 1.36m²T30 : 2.04m²

Brisip SP30.2m²

Cartridge 5"10"20"30"40"

: 0.34m2

: 0.68m2

: 1.36m2

: 2.04m2

: 2.72m2

Bricap SFU/V Disc Gas Filters

Aegivast (Gas) Series Part Number Configuator (PTFE)Capsule Filter Example : L03TTACEBA1P

P

P

Quantity/Package

1 1 / pkg

Cartridge Type


Cartridge Filters


0510203040

02738

Code


EVSP


A


Market

ACEBAFMBAFLB

ACE 0.2μm AFM 0.2μm AFL 0.2μm



L03L05L10L20L30

STKDMXVH


T10T20T30


Female Luer Lok™ Inlet and Male Luer Lok™Outlet (Bricap SFU Series only)1/4"-3/8" (6-9 mm) Stepped Hose BarbInlet and Outlet (Bricap V42 only)1/4"-1/2" (6-13 mm) Stepped Hose BarbInlet and Outlet (Bricap V50A & V50D only)

U13U25U33V42V5AV5D

CP

EE

BB

Bricap SFU13Bricap SFU25Bricap SFU33Bricap V42Bricap V50ABricap V50D

AS

AutoclavableSterile

AS

AutoclavableSterile

AS

AutoclavableSterile


P


Bricap T Capsule


P1 1 / pkg

P

Quantity/Package MarketP1 1 / pkg

P

Inlet Outlet

Inlet Outlet

Capsule Formats


P


Membrane TypeACEBAFMB AFLK

ACE 0.2μm AFM 0.2μmAFL 0.2μm

Cartridge Filter Example : AACEB050S1P

1 1/2" (38 mm) Sanitary Flange

Brisip Steam-in-Place Capsule Filters

SP3 S PX T

Vent/ Drain6 mm Hose BarbVent Stäubli ConnectorDrain 6 mm Hose BarbStäubli Connector

Capsule Formats

Brisip SP3

PS 3


STKN

- 35 - - 36 -




Corevital APB FilterGamma-resistant Hydrophobic Filter

Features· High retention efficiency· Low differential pressure· Efficient bacteria and particulate retention· Gamma irradiation

Applications· Vent Filters for fermentors, tanks, etc. · Sterile-grade filtration for compressed air, oxygen, nitrogen etc.

Bricap C/D/LHydrophobic Polyvinylidene Fluoride (PVDF)Polypropylene (PP)Polypropylene (PP)Polypropylene (PP)Silicone0.2 μm



120

100

80

60

40

20

00 25.0 50.0 75.0 100.0 125.0 150.0

BB

Air Flow Rate - Cobetter Corevital APB Bricap C02 Capsule

BriScale Disc、 Bricap C、 Bricap L、 Bricap T : Autoclave (126°C, 60min, 3 times), Gamma irradiation or Pre-sterilizationBricap D : AutoclaveFilter Cartridges : SIP & Autoclave




·

··




80°C0.55 MPa / 25°C0.1 MPa / 80°C

Biological Safety



Bricap SFU/VSFU13 : 0.72cm²SFU25 : 3.4cm²SFU33 : 4.5cm²V42 : 13.8cm²V50A : 20cm²V50D : 20cm²

Bricap C/D C01 : 290cm²C02 : 640cm²C03 : 1000cm²D01 : 450 cm²

Bricap LL03 : 0.25m² L05 : 0.375m²L10 : 0.75m²L20 : 1.5m²L30 : 2.25m²

Bricap TT10 : 0.75m²T20 : 1.5m²T30 : 2.25m²

Cartridge 5"10"20"30"40"

: 0.375m2

: 0.75m2

: 1.5m2

: 2.25m2

: 3.0m2

Market

P

PQuantity/Package

AGS

Sterilization


12

1 / pkg2 / pkg



Inlet OutletA

B

Capsule Formats

A 5 0

A50 BriScale® A50

Corevital (Gas) Series Part Number Configuator (PVDF)Capsule Filter Example :C01APBBSA1P | Cartridge Filter Example: AAPBB050S1PBricap C Small Capsule Filter Series



L03L05L10L20L30

STKDMXVH



T10T20T30

STKN



Inlet OutletTA

B

YK

AS



AS

AutoclavableSterile

AS

AutoclavableSterile



P


P


Bricap T Capsule


P1 1 / pkg

P


Membrane Type

P

P

Quantity/Package

1 1 / pkg

Cartridge Type


Cartridge Filters


0510203040

02738

Code


EVSP


A


Cartridge Filter Example : ASNDB050S1P

Market

APBB APB 0.2μm

APBB APB 0.2μm

- 37 - - 38 -

Ordering Information

T15T20T38

DN15DN20DN38

S010525...

0.1 m²0.5 m²2.5 m²

S 316L 0.6Mpa

Filter Plate Material Inlet/Outlet/Rententate Surface FinishSeals Materials

01 S T15 A

A Mirror PolishSilicone

SH-CFHIndustry

PP Pharmaceutical

Design Pressure

XX


0.1 m² Stainless Steel Holder Process development and small-volume parentals production with an EFA of 0.1m2.Unique design is fully compliant with biopharmaceutical applications and their requirements.

Pilot SystemThroughput (50-100L)

TFF SystemCobetter is able to design TFF system based on customer specifications and requirements especially for Pilot Labs and Process Systems

H-CFH TFF Stainless Steel Holder

0.5 m² Stainless Steel Holder Accomodate an effective filter area of 0.5 m2 -2.5 m2 up to 5 m2

Consieve UET Cassette membranes have a high retention efficiency and are easy to clean/install. Available in a wide range of configurations.

Due to its design, it is easy to amplify/increase based on specific process requirements. The inner gaskets make installation/cleaning/storage/replacement quick and easy. Low working volume and high efficiency ensure product yields.

Ordering Information

000500080010003000500100

5 KD8 KD10 KD30 KD50 KD100 KD

UF LAFLSC

100 cm²0.11 m²0.46 m²2.33 m²

E PESUltrafiltration

Material of membrane Format Effective Filtration AreaNMWL

UF LA 0005 010

001010050250

E

TFF Cassettes

MaterialsMaterial FeaturesPH Range NMWLOperating Temperature RangeMax. Operating PressureDiffusion Flow (Air)

Pressure Drop

PESLow protein binding and high product yield superior flow rates

Broad chemical compatibility: pH 1-14

5/8/10/30/50/100KD

Information

4-50°C6.0 bar @ 25°C0.11 m² ≤12ml/[email protected], 0.46 m² ≤50ml/[email protected]

0.3~0.6 bar ( Circulation Flow Rate 6L/min/m² )

Types Available Size Notes

Membrane Cassette ; Stainless Steel Holder required

Plastic Housing , self-clamping

Lab Flow SCU

LA FL SC

100 cm²0.11 m²0.46 m²2.33 m²0.11 m²

R&DR&D, Pilot ProductionPilot Production, Large Scale ProductionPilot Production, Large Scale Production

Applications Throughput

Industry

P

P Pharmaceutical

Application

· Biomacromolecules· Dialysis· Desalting· Buffer replacement· Analysis purification· Endotoxin removal· Macromolecular removal

· Blood products · Vaccines · Recombinant proteins · Monoterpenes · Plasmids· Chemicals· Chinese medicine injections

Applications Fields

R&D, Pilot Production

200-2000ml5-50L＞50L＞50L5-50L



Integrity Test InstrumentCF 7.2Specifications

Cleansteam Bag

Autoclave sterilization indicatorEthylene oxide sterilization indicator

Breathing SideHolding Side

Sterilization Indicators

Package

Arjo60-70 Dialysis Paper

Arjo60-70 Dialysis Paper

Temperature resistant medical composite membrane(PET+CPP)

High Density Polyethylene (HDPE)

Dupont Tyvek

Dupont Tyvek

Double-layer packaging: additional protection which protects the bags from scratching

100-240V AC , 50/60Hz 120W7-inch High-Definition Color Touchscreen450mm×280mm×190mmBubble Point (BP) : 100-8000 mbarDiffusion Flow (DF) : 1-600ml/minWater intrusion : 0.01-100ml/minManual Bubble Point TestBasic Bubble Point TestEnhanced Bubble Point TestPressure Holding/Pressure Decay TestDiffusion Flow TestWater Intrusion Test10000 mbar (150 psi) at least 1000mbar higher than the highest tested bubble pointTemperature Range : 5°C to 40°CRelative Humidity : 10% to 80%Net Volume Test Time : 4mins±2minsDiffusion Flow Test : 8mins±2minsBubble Point Test : 10mins±2minsEnhanced Bubble Point Test : 15mins±2minsWater Intrusion Test : estasblished testing time ± 2minssEnglish / Chinese language, Output Test parameters and result, Auto/manual print options Unlimited test records storage with SD card; USB connection to output dataEnglish / Chinese

Power RequirementsDisplay ScreenDimensionsTest Range

Test Method

Max. Operating PressureMinimum Input PressureOperating ConditionsTest Time Range

Print FunctionHistory Record FunctionLanguage Options

Vacuum Filter Specification

Membrane

Removal Ratings

150ml、250ml、500ml、1000ml

PES, CN, CA, NY

0.1 /0.2/0.45μm

Number of Filter Filter Length Materials End Cap Housing

ConnectionSealing Materials

Design Pressure

Surface Finish

01 1 round

H-SCF-A

H-SCF-B

01 05 F S TInlet/Outlet

T25 S A

05102030

5 inch10 inch20 inch30 inch

FS

304316L

T Tri-clamp T25 AB

Tri-clamp DN25 Mirror polishingInternalElectrolytic-polishing

X

0.6MPa1.0MPatwo drain valves

XY

STD

226222DOE

SEVF

SilliconeEPDMVitonPTFE

Filter Housing Catalog

1 round3 round

H-GCF 01 05 F S T T38 S A

0103

FS

304316L

S 226 Tri-clamp Flange

SEV

AB

SilliconeEPDMViton

Mirror PolishInternalElectro-polish

X

0.6MPa1.0MPa

TF

XY

05102030

5 inch10 inch20 inch30 inch

T25T38T50F25

Tri-clamp DN25Tri-clamp DN38Tri-clamp DN50Flange DN25

Membrane O.D. Material

01 1 membrane

H-DMF 01 47 F T T25 S A

4790

142200293

47mm90mm142mm200mm293mm

FS

304316L

TL

Tri-clamp Screwed Connection

SEV

AB

SilliconeEPDMViton


T25 Tri-clamp DN25

X

0.6MPaX

P

P Pharmaceutical

Industry

Number of Filter

Number of Membrane

Filter Length Materials End Cap Housing Connection

Sealing materials

Design Pressure

Surface FinishInlet/Outlet Industry

Housing Connection

Sealing Materials

Design PressureSurface FinishInlet/Outlet Industry

Number of Filter Filter Length Materials End Cap Housing

ConnectionSealing Materials

Design Pressure

Surface FinishInlet/Outlet Industry

P

P Pharmaceutical

P

P Pharmaceutical

01 1 roundH-VCF IIH-VCF 01 05 F S T T25 S A

0510

5 inch10 inch

FS

304316L

T Tri-clamp SEV

SilliconeEPDMViton

ST

226222

T25T38T50

Tri-clamp DN25Tri-clamp DN38Tri-clamp DN50

X

0.6MPaX

P

P Pharmaceutical

Sanitary Liquid Filter Housing

Vent Housing

Gas Filter Housing

Steel Membrane Holder

AB


- 41 - -42 -Filtration, Separation & Purification


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