The "GAL?" column shows whether a gene is a GAL gene (Y) or not (N), or whether it is adjacent (A).

ORF Systematic Common P MLdS MLdN sYLR081W_Skud9002.1.fasta YLR081W GAL2 P<E-10 1.8462 0.2479 321.1YBR020W_Skud9001.3.fasta YBR020W GAL1 P<E-10 1.4834 0.2798 292.1YBR019C_Skud9001.2.fasta YBR019C GAL10 P<E-10 1.3709 0.2528 210.8YBR018C_Skud9001.1.fasta YBR018C GAL7 P<E-10 1.3669 0.198 105.1YLR082C_Skud9002.2.fasta YLR082C SRL2 P<E-10 0.8051 0.1368 241.3YPL248C_Skud9004.1.fasta YPL248C GAL4 P<E-10 0.5394 0.2883 229.6YML051W_Skud9080.1.fasta YML051W GAL80 P<E-10 0.4615 0.1887 135.9YNL268W_Skud1360.1.fasta YNL268W LYP1 P<E-10 0.3498 0.0097 119.5YPL041C_Skud82.1.fasta YPL041C 3.8E-02 0.2568 0.0269 5.8YPL249C_Skud9004.2.fasta YPL249C GYP5 P<E-10 0.2376 0.1394 167.3_Skud1324.2.fasta 2.9E-03 0.2123 0.0054 7.2YML050W_Skud9080.3.fasta YML050W AIM32 P<E-10 0.2111 0.0477 55.8YDR041W_Skud1722.3.fasta YDR041W RSM10 P<E-10 0.1866 0.01 31.4YIR021W_Skud864.1.fasta YIR021W MRS1 P<E-10 0.1501 0.0194 45.5YBR229C_Skud1419.2.fasta YBR229C ROT2 P<E-10 0.1454 0.0259 113.0YJR148W_Skud1645.4.fasta YJR148W BAT2 P<E-10 0.142 0.0103 45.7YMR166C_Skud1124.2.fasta YMR166C P<E-10 0.1413 0.0092 45.8YBR021W_Skud968.2.fasta YBR021W FUR4 P<E-10 0.1402 0.0125 80.3YNL331C_Skud1830.5.fasta YNL331C AAD14 P<E-10 0.1378 0.0082 37.9YOR028C_Skud1983.3.fasta YOR028C CIN5 P<E-10 0.1293 0.0128 31.1YDR042C_Skud1722.2.fasta YDR042C 1.4E-07 0.1235 0.033 21.1YOR390W_Skud1996.8.fasta YOR390W P<E-10 0.121 0.0218 34.8YAR028W_Skud1492.4.fasta YAR028W 1.4E-05 0.1149 0.0559 18.7YMR170C_Skud1608.3.fasta YMR170C ALD2 P<E-10 0.1141 0.012 41.7YNL330C_Skud1996.12.fasta YNL330C RPD3 P<E-10 0.1075 0.0011 37.3YJR153W_Skud1830.3.fasta YJR153W PGU1 1.1E-08 0.1066 0.0077 29.0YGL158W_Skud2042.7.fasta YGL158W RCK1 P<E-10 0.1025 0.0212 37.4YJR154W_Skud1830.4.fasta YJR154W 2.2E-08 0.1014 0.0213 28.3YCL052C_Skud2065.7.fasta YCL052C PBN1 7.9E-10 0.0995 0.0266 33.6YLL017W_Skud1627.3.fasta YLL017W P<E-10 0.0956 0.0171 98.7YLL016W_Skud1627.2.fasta YLL016W P<E-10 0.0956 0.0171 98.7YJL213W_Skud1990.6.fasta YJL213W 7.2E-10 0.0952 0.0071 35.9YOL154W_Skud1876.3.fasta YOL154W ZPS1 9.1E-04 0.0948 0.0105 16.3YLR047C_Skud1993.1.fasta YLR047C FRE8 P<E-10 0.0947 0.0131 58.0YNR060W_Skud1943.5.fasta YNR060W FRE4 P<E-10 0.0925 0.009 53.9YBR228W_Skud1419.3.fasta YBR228W SLX1 3.6E-05 0.092 0.027 21.4YMR030W_Skud1450.6.fasta YMR030W RSF1 9.8E-07 0.0885 0.0185 27.3YLR054C_Skud1993.8.fasta YLR054C OSW2 2.8E-10 0.0884 0.0054 39.5YBR159W_Skud1852.2.fasta YBR159W IFA38 4.7E-06 0.0859 0.0086 26.6

Database S2. Divergence of all genes between Japanese (IFO1802T) and Portuguese (ZP591) reference strains.

Genes with significantly elevated levels of synonymous substitutions (dS) are shown in bold and sorted by the maximum likelihood estimate of Remaining genes are then sorted by Bonferroni-corrected P-values based on Poisson sampling of of the genome-wide average dS of 0.0207.The number of synonymous (s) and non-synonymous (n) substitutions, and the number of synonymous (Maximum likelihood estimate of dN (MLdN) are shown, but no genes had significantly elevated dN/dSModified Nei-Gojobori estimates (NGdS and NGdN) are also shown.ORFs with annotated single-copy orthologs in S. cerevisiae have systematic names, common names, and descriptions that correspond to the characterized For significantly divergent genes, putative homologs and functions were assigned based on synteny (when available) and the best BLASTX score to the

The "AA?" column shows whether a gene is involved in amino acid transport or metabolism in S. cerevisiaeNote that the GAL genes (P < 10-10), adjacent genes (P < 10-5), and genes involved in amino acid transport and metabolism (

YDR037W_Skud2038.11.fasta YDR037W KRS1 4.1E-08 0.0844 0.0028 34.9YIL169C_Skud1975.6.fasta YIL169C P<E-10 0.0831 0.0182 47.0YMR316W_Skud1561.1.fasta YMR316W DIA1 7.0E-04 0.0795 0.0305 22.0YMR266W_Skud2070.17.fastaYMR266W RSN1 P<E-10 0.0794 0.0112 65.7YJL212C_Skud1990.5.fasta YJL212C OPT1 1.5E-11 0.0793 0.0017 49.4_Skud2049.2.fasta 2.8E-08 0.0781 0.0169 38.8_Skud1796.5.fasta 1.9E-07 0.0755 0.0089 36.6YDR345C_Skud1649.3.fasta YDR345C HXT3 1.8E-05 0.0746 0.0066 29.9YJR149W_Skud1645.3.fasta YJR149W 1.2E-03 0.0741 0.0113 22.9YHR092C_Skud1506.3.fasta YHR092C HXT4 5.7E-06 0.0722 0.004 32.6YIL166C_Skud1969.3.fasta YIL166C 1.6E-05 0.0693 0.0018 32.7YOL148C_Skud1876.8.fasta YOL148C SPT20 2.4E-06 0.0691 0.0023 35.1_Skud1969.2.fasta 2.3E-02 0.0689 0.0082 18.4YOL144W_Skud1459.3.fasta YOL144W NOP8 1.6E-03 0.0654 0.0105 25.5_Skud2049.3.fasta 7.9E-03 0.0646 0.0073 22.4YKR039W_Skud2049.4.fasta YKR039W GAP1 8.6E-04 0.0633 0.0064 27.1YLR028C_Skud1684.4.fasta YLR028C ADE16 1.4E-03 0.0561 0.0018 33.7YFL055W_Skud1610.1.fasta YFL055W AGP3 3.1E-02 0.0543 0.0043 26.5YHR158C_Skud1735.3.fasta YHR158C KEL1 2.0E-02 0.0452 0.0038 39.2YKL071W_Skud1990.7.fasta YKL071W 7.8E-02 0.0739 0.0124 14.3YFR034C_Skud1504.3.fasta YFR034C PHO4 8.6E-02 0.0726 0.0084 15.9YOR362C_Skud2013.9.fasta YOR362C PRE10 1.0E-01 0.0664 0.0016 16.4YER143W_Skud1631.4.fasta YER143W DDI1 1.1E-01 0.0551 0.0041 21.1YMR117C_Skud2044.2.fasta YMR117C SPC24 1.3E-01 0.0732 0.0043 13.1YCR071C_Skud1012.1.fasta YCR071C IMG2 1.6E-01 0.0823 0.0034 11.2YML052W_Skud9080.2.fasta YML052W SUR7 1.6E-01 0.0612 0.0119 17.3YDR534C_Skud2001.13.fasta YDR534C FIT1 2.1E-01 0.0617 0.0163 17.8YOL124C_Skud1311.1.fasta YOL124C TRM11 3.4E-01 0.0532 0.0046 22.0YGL159W_Skud2042.5.fasta YGL159W 3.4E-01 0.0587 0.0146 16.0YAR019C_Skud1902.2.fasta YAR019C CDC15 4.0E-01 0.0406 0.0025 36.4YLR023C_Skud2025.2.fasta YLR023C IZH3 8.0E-01 0.0509 0.0032 19.4_Skud1975.1.fasta 1.0E+00 0.2589 0.0003 3.8YLR048W_Skud1993.2.fasta YLR048W RPS0B 1.1E+00 0.1326 0.0001 5.5YHR207C_Skud1913.1.fasta YHR207C SET5 1.2E+00 0.0475 0.0018 20.1YER098W_Skud2009.8.fasta YER098W UBP9 1.2E+00 0.0455 0.0064 23.5YIL077C_Skud1456.2.fasta YIL077C 1.2E+00 0.0574 0.0085 14.3YMR275C_Skud2070.8.fasta YMR275C BUL1 1.3E+00 0.0399 0.0062 31.1YER157W_Skud2047.6.fasta YER157W COG3 1.3E+00 0.0442 0.0027 24.3YHR122W_Skud1988.4.fasta YHR122W 1.9E+00 0.066 0.0033 11.9YLR328W_Skud2002.4.fasta YLR328W NMA1 2.1E+00 0.0524 0.0022 15.3YOR287C_Skud1737.4.fasta YOR287C 2.8E+00 0.0617 0.0049 10.0YBL068W_Skud1889.7.fasta YBL068W PRS4 2.8E+00 0.0541 0.0014 13.1YHR150W_Skud1820.4.fasta YHR150W PEX28 3.2E+00 0.0427 0.0041 22.3YDR256C_Skud1092.1.fasta YDR256C CTA1 3.3E+00 0.0476 0.0009 17.4YDL217C_Skud1815.5.fasta YDL217C TIM22 3.4E+00 0.0615 0.0022 10.2YOL014W_Skud1977.4.fasta YOL014W 4.0E+00 0.0833 0.0642 6.2YER054C_Skud2039.9.fasta YER054C GIP2 4.4E+00 0.0452 0.005 19.8YOL157C_Skud1565.2.fasta YOL157C 4.7E+00 0.0467 0.0043 17.6YLR417W_Skud1928.7.fasta YLR417W VPS36 5.0E+00 0.0444 0.0048 19.7YCL043C_Skud2072.3.fasta YCL043C PDI1 5.1E+00 0.0485 0.0008 16.9_Skud2072.4.fasta 5.1E+00 0.0485 0.0008 16.9YOL145C_Skud1459.2.fasta YOL145C CTR9 5.7E+00 0.0406 0.0031 23.5YDR087C_Skud1929.8.fasta YDR087C RRP1 5.8E+00 0.0534 0.0016 12.5

YDL215C_Skud1815.3.fasta YDL215C GDH2 5.9E+00 0.0368 0.0013 32.9YOR025W_Skud1983.6.fasta YOR025W HST3 6.8E+00 0.0478 0 15.7YKR076W_Skud2030.13.fasta YKR076W ECM4 7.5E+00 0.0517 0.0012 14.0YAL062W_Skud1984.2.fasta YAL062W GDH3 7.7E+00 0.0468 0.0061 17.0YPL126W_Skud2019.2.fasta YPL126W NAN1 7.9E+00 0.0374 0.0026 28.8YOR127W_Skud1941.5.fasta YOR127W RGA1 8.6E+00 0.037 0.0074 27.3YHR182W_Skud2046.6.fasta YHR182W 9.2E+00 0.0374 0.0184 26.4YNR046W_Skud449.2.fasta YNR046W TRM112 1.0E+01 0.0705 0.0032 6.1_Skud1909.4.fasta 1.2E+01 0.0985 0.0132 4.6_Skud1141.1.fasta 1.3E+01 0.0959 0.0001 4.6YOR214C_Skud1769.2.fasta YOR214C 1.3E+01 0.0535 0.0083 10.6YNR054C_Skud1826.5.fasta YNR054C ESF2 1.4E+01 0.0533 0.0148 10.6YJL046W_Skud1771.5.fasta YJL046W AIM22 1.5E+01 0.0453 0.0086 13.2YNL234W_Skud1688.2.fasta YNL234W 1.6E+01 0.0424 0.0097 15.2YGL162W_Skud2042.2.fasta YGL162W SUT1 1.6E+01 0.0478 0.0149 12.6YIL091C_Skud1880.6.fasta YIL091C 1.6E+01 0.0385 0.0037 20.3YGR049W_Skud2031.10.fasta YGR049W SCM4 1.6E+01 0.0577 0.0024 8.5YKL063C_Skud1582.4.fasta YKL063C 1.7E+01 0.0662 0.0025 6.4YKL215C_Skud1994.6.fasta YKL215C 1.7E+01 0.0728 0.0245 5.3YDL156W_Skud1673.4.fasta YDL156W CMR1 1.8E+01 0.0403 0.0037 18.6YAR031W_Skud729.1.fasta YAR031W PRM9 1.9E+01 0.0616 0.0671 6.0YBR093C_Skud2011.2.fasta YBR093C PHO5 2.0E+01 0.0458 0.0009 12.4YLR192C_Skud1827.2.fasta YLR192C HCR1 2.0E+01 0.0495 0.0251 11.9YGR184C_Skud2063.14.fasta YGR184C UBR1 2.1E+01 0.0357 0.0048 24.3YGR056W_Skud2031.5.fasta YGR056W RSC1 2.1E+01 0.0362 0.0038 24.7YPL242C_Skud1905.5.fasta YPL242C IQG1 2.2E+01 0.0399 0.0109 17.5_Skud2042.6.fasta 2.2E+01 0.0586 0.0143 7.4YOR162C_Skud1300.2.fasta YOR162C YRR1 2.3E+01 0.0359 0.0104 24.6YLR030W_Skud1684.6.fasta YLR030W 2.3E+01 0.0424 0.0279 15.8YLR031W_Skud1684.7.fasta YLR031W 2.3E+01 0.0424 0.0279 15.8YDR265W_Skud2012.9.fasta YDR265W PEX10 2.5E+01 0.045 0.0097 12.5YGR179C_Skud2063.10.fasta YGR179C OKP1 2.5E+01 0.0422 0.007 14.5YIL118W_Skud1925.5.fasta YIL118W RHO3 2.5E+01 0.0552 0.0038 8.7YNR059W_Skud1943.4.fasta YNR059W MNT4 2.5E+01 0.0387 0.0091 19.8YGR041W_Skud1839.6.fasta YGR041W BUD9 2.6E+01 0.0397 0.0075 16.3YGR251W_Skud1999.7.fasta YGR251W 2.7E+01 0.058 0.0069 7.6YGL254W_Skud1439.2.fasta YGL254W FZF1 2.8E+01 0.0445 0.0137 12.6YDL084W_Skud2062.8.fasta YDL084W SUB2 2.9E+01 0.0437 0 12.4YNL144C_Skud1924.9.fasta YNL144C 2.9E+01 0.0368 0.0067 20.5YGR063C_Skud1195.2.fasta YGR063C SPT4 3.1E+01 0.0661 0.0001 5.5YMR267W_Skud2070.16.fasta YMR267W PPA2 3.1E+01 0.0475 0.0057 10.6YKR085C_Skud983.2.fasta YKR085C MRPL20 3.2E+01 0.051 0.0001 8.4YHR132W-A_Skud2014.15.fasta YHR132W-A IGO2 3.2E+01 0.0695 0.0001 5.8YBR233W_Skud1458.2.fasta YBR233W PBP2 3.2E+01 0.0412 0.0048 16.0YNL121C_Skud1922.3.fasta YNL121C TOM70 3.3E+01 0.0377 0.0031 19.8YCR048W_Skud1526.1.fasta YCR048W ARE1 3.3E+01 0.0397 0.0077 16.7YDR089W_Skud1929.11.fasta YDR089W 3.4E+01 0.0341 0.0033 25.4YJL171C_Skud1241.2.fasta YJL171C 3.4E+01 0.0426 0.0012 13.7YJR055W_Skud1317.1.fasta YJR055W HIT1 3.6E+01 0.0594 0.0026 6.6YEL070W_Skud1560.2.fasta YEL070W DSF1 3.6E+01 0.0643 0.0001 5.5YLR205C_Skud1413.3.fasta YLR205C HMX1 3.7E+01 0.0452 0.0029 10.4YNR010W_Skud1932.1.fasta YNR010W CSE2 3.7E+01 0.0578 0.0029 6.5YER058W_Skud2039.14.fasta YER058W PET117 3.8E+01 0.062 0.0042 5.3

YPL060W_Skud1974.3.fasta YPL060W LPE10 3.8E+01 0.0617 0.0089 5.3YOR163W_Skud2050.15.fasta YOR163W DDP1 3.8E+01 0.0589 0.0001 6.6YBR124W_Skud1334.3.fasta YBR124W 4.1E+01 0.0719 0.0149 4.5YKL054C_Skud2056.13.fasta YKL054C DEF1 4.2E+01 0.0388 0.0025 16.9YBR062C_Skud1976.3.fasta YBR062C 4.4E+01 0.0706 0.0001 4.5YNL079C_Skud1628.4.fasta YNL079C TPM1 4.4E+01 0.0671 0.002 6.0YEL066W_Skud1597.4.fasta YEL066W HPA3 4.4E+01 0.0516 0.0033 7.4YPR081C_Skud1982.1.fasta YPR081C GRS2 4.5E+01 0.0361 0.0088 19.6YER175C_Skud1863.4.fasta YER175C TMT1 4.5E+01 0.0443 0.0048 11.9YOR294W_Skud1838.2.fasta YOR294W RRS1 4.5E+01 0.0526 0.0112 7.6_Skud1167.1.fasta 4.6E+01 0.1047 0.0001 2.4YOL136C_Skud2006.1.fasta YOL136C PFK27 4.8E+01 0.0433 0 11.7YBR288C_Skud1898.2.fasta YBR288C APM3 4.8E+01 0.0391 0.0077 14.5YIL007C_Skud1909.6.fasta YIL007C NAS2 5.1E+01 0.0518 0.0057 7.7YHR139C_Skud2014.8.fasta YHR139C SPS100 5.1E+01 0.0398 0.0015 12.2YDR043C_Skud1722.1.fasta YDR043C NRG1 5.2E+01 0.0439 0.0041 9.2YLL004W_Skud1276.1.fasta YLL004W ORC3 5.2E+01 0.101 0.0001 2.4YNL195C_Skud1800.3.fasta YNL195C 5.4E+01 0.0462 0.0123 9.7YGL026C_Skud2052.3.fasta YGL026C TRP5 5.7E+01 0.0335 0.0014 21.1YHR116W_Skud2024.3.fasta YHR116W COX23 5.9E+01 0.0559 0.0104 5.3YKR066C_Skud2030.3.fasta YKR066C CCP1 6.2E+01 0.0456 0.0046 9.8YPR040W_Skud1404.2.fasta YPR040W TIP41 6.2E+01 0.042 0.0036 10.4YKL062W_Skud1582.3.fasta YKL062W MSN4 6.7E+01 0.0337 0.0111 20.4YER185W_Skud1796.2.fasta YER185W PUG1 6.7E+01 0.0417 0.005 11.8YOL096C_Skud1079.2.fasta YOL096C COQ3 6.8E+01 0.0423 0.003 10.6YML120C_Skud1679.3.fasta YML120C NDI1 6.9E+01 0.0384 0 14.9YKL121W_Skud2020.4.fasta YKL121W DGR2 7.0E+01 0.0326 0.0033 22.2YNL241C_Skud1579.2.fasta YNL241C ZWF1 7.0E+01 0.0388 0.0009 13.8YDL216C_Skud1815.4.fasta YDL216C RRI1 7.1E+01 0.039 0.0021 13.8YER144C_Skud1631.3.fasta YER144C UBP5 7.1E+01 0.0324 0.0104 24.6YLL035W_Skud1548.2.fasta YLL035W GRC3 7.1E+01 0.0358 0.0036 17.8YMR018W_Skud2054.11.fasta YMR018W 7.1E+01 0.0401 0.0008 12.9YIL084C_Skud1094.2.fasta YIL084C SDS3 7.2E+01 0.0409 0.0097 10.4YJL082W_Skud1768.3.fasta YJL082W IML2 7.3E+01 0.0347 0.0018 18.6YBR071W_Skud1650.5.fasta YBR071W 7.5E+01 0.0436 0.0022 8.3YAR003W_Skud1902.7.fasta YAR003W SWD1 7.6E+01 0.039 0.0032 12.6YKR041W_Skud636.1.fasta YKR041W 7.6E+01 0.0413 0.0287 10.6YJL037W_Skud1771.6.fasta YJL037W IRC18 7.6E+01 0.0423 0.0022 8.1YHR195W_Skud1689.4.fasta YHR195W NVJ1 7.6E+01 0.0431 0.0041 9.6YJR107W_Skud1281.2.fasta YJR107W 8.0E+01 0.0401 0.0041 11.7YDL147W_Skud1602.4.fasta YDL147W RPN5 8.0E+01 0.0375 0.001 12.2YDR031W_Skud2038.4.fasta YDR031W MIC14 8.0E+01 0.0575 0.007 4.3YHR053C_Skud1347.4.fasta YHR053C CUP1-1 8.1E+01 0.065 0.0082 3.3_Skud1994.2.fasta 8.1E+01 0.0651 0.0503 3.3YHR204W_Skud1913.4.fasta YHR204W MNL1 8.1E+01 0.0336 0.0035 22.0YAL059W_Skud1874.2.fasta YAL059W ECM1 8.2E+01 0.0447 0 7.2_Skud1861.2.fasta 8.5E+01 0.0643 0.0373 3.3YKR007W_Skud1938.4.fasta YKR007W MEH1 8.5E+01 0.0531 0.0047 5.5YBR017C_Skud968.1.fasta YBR017C KAP104 8.6E+01 0.032 0.008 26.0YGL017W_Skud1875.6.fasta YGL017W ATE1 8.7E+01 0.0368 0.0046 14.7YML011C_Skud1245.3.fasta YML011C RAD33 8.7E+01 0.0508 0.005 6.8YOL080C_Skud1718.6.fasta YOL080C REX4 8.8E+01 0.0413 0.005 9.4YGL160W_Skud2042.4.fasta YGL160W AIM14 8.9E+01 0.0342 0.0104 17.5

YOL001W_Skud1890.4.fasta YOL001W PHO80 9.0E+01 0.0387 0.0033 10.2YGL223C_Skud1804.7.fasta YGL223C COG1 9.2E+01 0.0366 0.0044 12.2YKL217W_Skud1994.4.fasta YKL217W JEN1 9.2E+01 0.0336 0.0033 19.7YDL170W_Skud1601.2.fasta YDL170W UGA3 9.2E+01 0.0351 0.0017 14.2YMR195W_Skud1752.2.fasta YMR195W ICY1 9.3E+01 0.0523 0.0041 5.5YPL159C_Skud2033.9.fasta YPL159C PET20 9.7E+01 0.04 0.0095 9.3YDL223C_Skud1979.8.fasta YDL223C HBT1 9.9E+01 0.031 0.0152 27.9YDR315C_Skud681.1.fasta YDR315C IPK1 9.9E+01 0.0411 0.0045 9.6YJL072C_Skud1221.2.fasta YJL072C PSF2 1.0E+02 0.0435 0.0064 7.4YGR117C_Skud1724.2.fasta YGR117C 1.0E+02 0.0349 0.0061 14.3YKL141W_Skud1823.8.fasta YKL141W SDH3 1.0E+02 0.0422 0.0025 7.2YFL041W_Skud1045.1.fasta YFL041W FET5 1.1E+02 0.0332 0.0029 16.1YOR370C_Skud2013.2.fasta YOR370C MRS6 1.1E+02 0.0332 0 16.1YLR126C_Skud1611.3.fasta YLR126C 1.1E+02 0.0387 0.0061 9.1YPL274W_Skud2029.3.fasta YPL274W SAM3 1.1E+02 0.0352 0.0036 15.8YIL027C_Skud1791.5.fasta YIL027C KRE27 1.1E+02 0.0476 0 5.2YIL164C_Skud1969.5.fasta YIL164C NIT1 1.1E+02 0.0393 0.0015 10.6YIL165C_Skud1969.4.fasta YIL165C 1.1E+02 0.0393 0.0015 10.6YLR283W_Skud2059.19.fasta YLR283W 1.1E+02 0.0613 0.0245 3.4YJL218W_Skud1861.3.fasta YJL218W 1.1E+02 0.0437 0.0049 7.5YDR444W_Skud1894.4.fasta YDR444W 1.1E+02 0.0343 0.0027 18.0YPL108W_Skud1710.4.fasta YPL108W 1.1E+02 0.0423 0.0034 7.3YLL051C_Skud1624.4.fasta YLL051C FRE6 1.1E+02 0.0326 0.0081 19.6YGR042W_Skud1839.5.fasta YGR042W 1.1E+02 0.0401 0.0127 8.2YDR304C_Skud1967.8.fasta YDR304C CPR5 1.1E+02 0.0495 0.0018 7.0YHR069C_Skud867.2.fasta YHR069C RRP4 1.1E+02 0.0408 0.004 8.4YML069W_Skud2021.7.fasta YML069W POB3 1.1E+02 0.0343 0.0024 13.0YMR146C_Skud1371.3.fasta YMR146C TIF34 1.2E+02 0.0392 0.0026 10.8YHR196W_Skud1689.3.fasta YHR196W UTP9 1.2E+02 0.0353 0.0039 14.7YKL061W_Skud1582.2.fasta YKL061W 1.2E+02 0.0502 0.0119 4.2YPL077C_Skud1921.5.fasta YPL077C 1.2E+02 0.0431 0.0075 7.5YHR029C_Skud1508.4.fasta YHR029C YHI9 1.2E+02 0.0397 0.0061 9.6YCR009C_Skud1966.2.fasta YCR009C RVS161 1.2E+02 0.0421 0 7.4YER071C_Skud1843.4.fasta YER071C TDA2 1.2E+02 0.0499 0.0102 4.2YCR082W_Skud1764.2.fasta YCR082W AHC2 1.2E+02 0.0538 0.0033 4.5YDR113C_Skud1927.4.fasta YDR113C PDS1 1.2E+02 0.0341 0.0056 13.1YDR516C_Skud1594.5.fasta YDR516C EMI2 1.2E+02 0.0334 0 14.0YDR131C_Skud1908.6.fasta YDR131C 1.2E+02 0.033 0.0061 16.3YFR008W_Skud1792.2.fasta YFR008W FAR7 1.2E+02 0.041 0 7.2YML097C_Skud1950.4.fasta YML097C VPS9 1.3E+02 0.0353 0.0052 13.6YDR267C_Skud2012.11.fasta YDR267C CIA1 1.3E+02 0.0381 0 10.6YGR125W_Skud1864.4.fasta YGR125W 1.3E+02 0.0294 0.0028 26.0YGL101W_Skud1658.4.fasta YGL101W 1.3E+02 0.0453 0.002 6.6YCR019W_Skud2048.3.fasta YCR019W MAK32 1.3E+02 0.0386 0.0025 10.8YEL061C_Skud1923.7.fasta YEL061C CIN8 1.3E+02 0.0309 0.0022 22.5YBR258C_Skud2064.15.fasta YBR258C SHG1 1.4E+02 0.0513 0.0059 4.5YLR299W_Skud2059.4.fasta YLR299W ECM38 1.4E+02 0.0323 0.0042 17.4YDR525W-A_Skud2001.5.fasta YDR525W-A SNA2 1.4E+02 0.0479 0 4.2YOR316C_Skud1795.7.fasta YOR316C COT1 1.4E+02 0.0335 0.0057 14.4YGR052W_Skud2031.9.fasta YGR052W FMP48 1.4E+02 0.0355 0.0068 12.6YKL086W_Skud475.1.fasta YKL086W SRX1 1.5E+02 0.0707 0.0689 2.5YHR097C_Skud1335.2.fasta YHR097C 1.5E+02 0.0407 0.002 7.4YBR282W_Skud1898.8.fasta YBR282W MRPL27 1.5E+02 0.0435 0.0032 5.1

YPL047W_Skud1641.3.fasta YPL047W SGF11 1.5E+02 0.0513 0.0043 3.1YGR248W_Skud1999.10.fasta YGR248W SOL4 1.5E+02 0.0404 0.0095 8.7YDL235C_Skud1224.2.fasta YDL235C YPD1 1.5E+02 0.0417 0.0029 6.3YGR178C_Skud2063.9.fasta YGR178C PBP1 1.5E+02 0.0333 0.0024 16.9YML056C_Skud1726.5.fasta YML056C IMD4 1.5E+02 0.0389 0.0027 9.8YBR230C_Skud1419.1.fasta YBR230C OM14 1.5E+02 0.0413 0 6.2YBR087W_Skud2011.8.fasta YBR087W RFC5 1.5E+02 0.037 0 11.9YBR009C_Skud532.1.fasta YBR009C HHF1 1.5E+02 0.0539 0.0001 3.3YER158C_Skud2047.7.fasta YER158C 1.5E+02 0.0313 0.0064 17.1YAL010C_Skud1474.2.fasta YAL010C MDM10 1.5E+02 0.0331 0.008 14.3YFR044C_Skud1972.11.fasta YFR044C DUG1 1.6E+02 0.0349 0.001 13.8YGL146C_Skud1895.3.fasta YGL146C RRT6 1.6E+02 0.0396 0.0042 8.6YOR119C_Skud1746.4.fasta YOR119C RIO1 1.6E+02 0.0379 0.0017 10.9YOR106W_Skud2018.7.fasta YOR106W VAM3 1.6E+02 0.0361 0.0103 9.1YLR326W_Skud2002.2.fasta YLR326W 1.6E+02 0.0375 0.0041 8.2YNR015W_Skud1185.3.fasta YNR015W SMM1 1.6E+02 0.0457 0.0063 4.2_Skud1299.1.fasta 1.6E+02 0.0783 0.0001 1.2_Skud1899.2.fasta 1.7E+02 0.0396 0.0025 7.4YMR279C_Skud2070.4.fasta YMR279C 1.7E+02 0.0319 0.0036 15.2YOR348C_Skud1348.2.fasta YOR348C PUT4 1.7E+02 0.0407 0.0092 6.3YOR351C_Skud1930.8.fasta YOR351C MEK1 1.7E+02 0.0348 0.0009 12.7YKL221W_Skud1775.3.fasta YKL221W MCH2 1.7E+02 0.0406 0.0024 6.3YKL090W_Skud1457.2.fasta YKL090W CUE2 1.7E+02 0.0345 0.0032 12.6YDL114W_Skud1480.4.fasta YDL114W 1.7E+02 0.039 0.0073 8.7YDL237W_Skud1369.1.fasta YDL237W AIM6 1.8E+02 0.0346 0.0023 10.2YMR160W_Skud1956.3.fasta YMR160W 1.8E+02 0.0304 0.0029 20.5YDL005C_Skud1672.3.fasta YDL005C MED2 1.8E+02 0.0358 0.0084 10.5YBR022W_Skud968.3.fasta YBR022W POA1 1.8E+02 0.042 0.0177 5.2YMR257C_Skud2070.26.fasta YMR257C PET111 1.8E+02 0.0295 0.0063 22.2YJL102W_Skud1954.9.fasta YJL102W MEF2 1.8E+02 0.0309 0.0034 19.6YOR037W_Skud2015.4.fasta YOR037W CYC2 1.8E+02 0.0349 0.0051 10.3YLR080W_Skud989.6.fasta YLR080W EMP46 1.8E+02 0.0337 0.0116 12.4YML021C_Skud2017.7.fasta YML021C UNG1 1.8E+02 0.0332 0.007 11.0YMR156C_Skud1956.7.fasta YMR156C TPP1 1.8E+02 0.0396 0.0038 7.6YER109C_Skud1711.4.fasta YER109C FLO8 1.8E+02 0.0295 0.0074 21.1YDL095W_Skud1105.1.fasta YDL095W PMT1 1.8E+02 0.0303 0.0041 20.5YIL083C_Skud1094.1.fasta YIL083C CAB2 1.9E+02 0.0347 0 10.3YOL153C_Skud1876.4.fasta YOL153C 1.9E+02 0.0318 0.0033 16.6YPL067C_Skud1974.9.fasta YPL067C 1.9E+02 0.0385 0.0103 7.4YGL256W_Skud2049.8.fasta YGL256W ADH4 1.9E+02 0.0348 0.0022 12.9YKL022C_Skud1981.6.fasta YKL022C CDC16 1.9E+02 0.0304 0.0011 17.1YGR181W_Skud2063.12.fasta YGR181W TIM13 1.9E+02 0.044 0.0049 4.2YDR034C_Skud2038.7.fasta YDR034C LYS14 1.9E+02 0.0307 0.003 19.7YJR013W_Skud1955.3.fasta YJR013W GPI14 1.9E+02 0.0317 0.004 13.0YOR288C_Skud1737.3.fasta YOR288C MPD1 2.0E+02 0.037 0.0027 8.5YPR002W_Skud1777.8.fasta YPR002W PDH1 2.0E+02 0.0335 0.0036 13.8YOR365C_Skud2013.6.fasta YOR365C 2.0E+02 0.0312 0.0048 18.8YAL034W-A_Skud1685.6.fasta YAL034W-A MTW1 2.0E+02 0.0366 0 7.1YMR174C_Skud1860.2.fasta YMR174C PAI3 2.0E+02 0.053 0.0061 2.1YHR163W_Skud956.1.fasta YHR163W SOL3 2.0E+02 0.0385 0.0036 7.5YCL039W_Skud2072.6.fasta YCL039W GID7 2.0E+02 0.0311 0.0034 16.4YDR482C_Skud1730.4.fasta YDR482C CWC21 2.0E+02 0.0419 0.0068 4.1YGR153W_Skud1477.2.fasta YGR153W 2.0E+02 0.0394 0.0124 6.4

_Skud1966.5.fasta 2.1E+02 0.0412 0.0171 6.7YER035W_Skud455.2.fasta YER035W EDC2 2.1E+02 0.042 0 5.4YAL060W_Skud1874.1.fasta YAL060W BDH1 2.1E+02 0.0355 0 10.7YBR119W_Skud1759.3.fasta YBR119W MUD1 2.1E+02 0.0362 0.0127 7.1YDL028C_Skud1646.3.fasta YDL028C MPS1 2.1E+02 0.0292 0.005 20.1YHR065C_Skud841.2.fasta YHR065C RRP3 2.1E+02 0.039 0 7.7YNL122C_Skud1922.4.fasta YNL122C 2.1E+02 0.0451 0 3.1YKR001C_Skud1712.3.fasta YKR001C VPS1 2.1E+02 0.0314 0 16.7YLR154C_Skud1743.3.fasta YLR154C RNH203 2.2E+02 0.0459 0.0096 3.2YBR135W_Skud1937.10.fasta YBR135W CKS1 2.2E+02 0.0433 0.0032 4.3YDR532C_Skud2001.11.fasta YDR532C 2.2E+02 0.0345 0.0046 9.3YLR370C_Skud2027.5.fasta YLR370C ARC18 2.2E+02 0.0397 0 5.2YIL080W_Skud2023.5.fasta YIL080W 2.2E+02 0.0728 0.0001 1.4YFR046C_Skud1972.9.fasta YFR046C CNN1 2.2E+02 0.038 0.0095 8.9YAR071W_Skud1975.5.fasta YAR071W PHO11 2.3E+02 0.0402 0.0071 5.3YOR377W_Skud2036.8.fasta YOR377W ATF1 2.3E+02 0.0328 0.0026 13.8YOR103C_Skud2018.9.fasta YOR103C OST2 2.3E+02 0.042 0.0072 4.2YIL106W_Skud1790.4.fasta YIL106W MOB1 2.3E+02 0.042 0 5.6YDL060W_Skud1991.3.fasta YDL060W TSR1 2.3E+02 0.0304 0.0035 20.0YBR044C_Skud1853.5.fasta YBR044C TCM62 2.4E+02 0.0309 0.0048 14.3YEL069C_Skud1796.3.fasta YEL069C HXT13 2.4E+02 0.0404 0.0103 5.4YDR318W_Skud1476.2.fasta YDR318W MCM21 2.4E+02 0.0364 0.0076 7.4YGL154C_Skud2042.11.fasta YGL154C LYS5 2.5E+02 0.0375 0.0116 7.6YLR449W_Skud1639.3.fasta YLR449W FPR4 2.5E+02 0.0374 0.0034 8.9YPL233W_Skud1578.3.fasta YPL233W NSL1 2.5E+02 0.037 0 6.3YBR154C_Skud2051.5.fasta YBR154C RPB5 2.5E+02 0.039 0 6.6YNR021W_Skud1660.6.fasta YNR021W 2.5E+02 0.0336 0 8.1YHR193C_Skud1689.6.fasta YHR193C EGD2 2.5E+02 0.041 0 5.6YNR058W_Skud1943.3.fasta YNR058W BIO3 2.5E+02 0.0327 0.001 12.7YFL030W_Skud1145.1.fasta YFL030W AGX1 2.5E+02 0.034 0.0012 9.4YLR132C_Skud1776.7.fasta YLR132C 2.5E+02 0.0355 0.0032 8.5YLR108C_Skud2004.3.fasta YLR108C 2.5E+02 0.0305 0.0052 14.2YDL088C_Skud2062.3.fasta YDL088C ASM4 2.5E+02 0.0315 0.0045 13.5_Skud2055.6.fasta 2.6E+02 0.0453 0.0082 2.0YHR205W_Skud1913.3.fasta YHR205W SCH9 2.6E+02 0.0318 0.0021 11.2YPL033C_Skud1118.2.fasta YPL033C SRL4 2.6E+02 0.0385 0.0045 6.6YOL038W_Skud1723.3.fasta YOL038W PRE6 2.6E+02 0.0346 0.0019 7.1YOR036W_Skud2015.3.fasta YOR036W PEP12 2.6E+02 0.0368 0 7.6YBL029W_Skud2007.7.fasta YBL029W 2.6E+02 0.0321 0.0053 11.3YKL218C_Skud1994.3.fasta YKL218C SRY1 2.6E+02 0.0355 0.0041 8.6YBL015W_Skud1914.3.fasta YBL015W ACH1 2.6E+02 0.0306 0 14.3YJL148W_Skud2041.15.fasta YJL148W RPA34 2.7E+02 0.0384 0.0037 5.3YPL038W_Skud1396.3.fasta YPL038W MET31 2.7E+02 0.0375 0.0053 5.2YKR068C_Skud2030.5.fasta YKR068C BET3 2.7E+02 0.043 0.0021 4.5YBL028C_Skud2007.6.fasta YBL028C 2.7E+02 0.0458 0 2.1YCR052W_Skud2008.2.fasta YCR052W RSC6 2.7E+02 0.0301 0.0095 14.2YBR052C_Skud1787.5.fasta YBR052C RFS1 2.7E+02 0.0397 0 5.5YHL019C_Skud1229.1.fasta YHL019C APM2 2.7E+02 0.0311 0.0088 12.3YPL235W_Skud1578.5.fasta YPL235W RVB2 2.8E+02 0.031 0 13.4YGL035C_Skud2052.11.fasta YGL035C MIG1 2.8E+02 0.0314 0.007 14.8YGL156W_Skud2042.9.fasta YGL156W AMS1 2.8E+02 0.0283 0.0026 25.9YLR273C_Skud1933.2.fasta YLR273C PIG1 2.8E+02 0.0327 0.0054 12.9YBR213W_Skud1615.3.fasta YBR213W MET8 2.8E+02 0.0336 0.0053 8.2

YDL059C_Skud1991.2.fasta YDL059C RAD59 2.8E+02 0.0346 0.0021 7.2YKR022C_Skud1297.2.fasta YKR022C NTR2 2.8E+02 0.0355 0.0083 8.7YML095C_Skud1950.2.fasta YML095C RAD10 2.8E+02 0.0373 0.0051 5.2YHR061C_Skud1807.5.fasta YHR061C GIC1 2.8E+02 0.0373 0.008 7.8YAR002C-A_Skud1902.8.fasta YAR002C-A ERP1 2.9E+02 0.0398 0 5.6YLR187W_Skud2032.5.fasta YLR187W SKG3 2.9E+02 0.0276 0.0047 23.1YER061C_Skud1762.2.fasta YER061C CEM1 2.9E+02 0.0314 0 12.5YPL255W_Skud302.6.fasta YPL255W BBP1 2.9E+02 0.0308 0.0023 12.2YBL061C_Skud1907.2.fasta YBL061C SKT5 2.9E+02 0.0327 0.004 10.5YNL130C_Skud1749.4.fasta YNL130C CPT1 2.9E+02 0.0353 0 8.7YNL137C_Skud1855.3.fasta YNL137C NAM9 2.9E+02 0.0326 0.0058 13.0_Skud1492.3.fasta 2.9E+02 0.0382 0.0045 5.4YAL008W_Skud1474.4.fasta YAL008W FUN14 2.9E+02 0.0394 0.0101 6.9YHR001W-A_Skud2067.21.fasta YHR001W-A QCR10 2.9E+02 0.0393 0 3.0YGR284C_Skud1618.4.fasta YGR284C ERV29 2.9E+02 0.0316 0 9.0YDR391C_Skud1381.2.fasta YDR391C 3.0E+02 0.0366 0.004 6.5YGR185C_Skud2063.15.fasta YGR185C TYS1 3.0E+02 0.0315 0.0025 11.4YLR093C_Skud1001.2.fasta YLR093C NYV1 3.0E+02 0.0365 0 6.4YEL068C_Skud1597.3.fasta YEL068C 3.0E+02 0.0454 0.0616 2.2YFL017C_Skud1575.5.fasta YFL017C GNA1 3.0E+02 0.0425 0.0026 3.3YPR042C_Skud1654.2.fasta YPR042C PUF2 3.0E+02 0.0277 0.005 24.5YIL041W_Skud1799.5.fasta YIL041W GVP36 3.0E+02 0.0325 0.003 9.3YDL181W_Skud2045.9.fasta YDL181W INH1 3.0E+02 0.0432 0 2.1YHR015W_Skud2067.5.fasta YHR015W MIP6 3.0E+02 0.0303 0.0055 14.5YJR095W_Skud1662.4.fasta YJR095W SFC1 3.0E+02 0.0321 0.0015 9.2YPL002C_Skud1777.5.fasta YPL002C SNF8 3.0E+02 0.0386 0.0036 5.5YOR371C_Skud2013.1.fasta YOR371C GPB1 3.0E+02 0.0292 0.0047 19.9YBL050W_Skud1725.3.fasta YBL050W SEC17 3.0E+02 0.0331 0.0017 8.3YBR295W_Skud1849.4.fasta YBR295W PCA1 3.1E+02 0.0271 0.009 26.3YOR359W_Skud2013.12.fasta YOR359W VTS1 3.1E+02 0.0303 0.0049 15.8YER050C_Skud2039.4.fasta YER050C RSM18 3.1E+02 0.0383 0.01 4.2YNL061W_Skud1596.1.fasta YNL061W NOP2 3.1E+02 0.0299 0.0014 12.0YPL084W_Skud1514.3.fasta YPL084W BRO1 3.1E+02 0.029 0.0043 18.6YBR046C_Skud1853.2.fasta YBR046C ZTA1 3.1E+02 0.032 0.0058 9.2YOL094C_Skud1742.6.fasta YOL094C RFC4 3.1E+02 0.0333 0.0043 8.4YGL090W_Skud1808.7.fasta YGL090W LIF1 3.1E+02 0.0314 0.0043 10.2YCL057C-A_Skud2065.12.fasta YCL057C-A 3.1E+02 0.0411 0 3.2YCR007C_Skud1966.4.fasta YCR007C 3.1E+02 0.04 0.0028 4.4YKL094W_Skud1258.2.fasta YKL094W YJU3 3.1E+02 0.0386 0.0168 4.3YPL052W_Skud1641.8.fasta YPL052W OAZ1 3.1E+02 0.0337 0.0061 6.0YLL055W_Skud1882.9.fasta YLL055W YCT1 3.1E+02 0.03 0.0038 14.5YCR033W_Skud2035.6.fasta YCR033W SNT1 3.1E+02 0.0272 0.0106 28.7YOL052C-A_Skud687.1.fasta YOL052C-A DDR2 3.2E+02 0.0438 0 2.2YLL062C_Skud1882.3.fasta YLL062C MHT1 3.2E+02 0.0331 0.0071 8.4YKL192C_Skud1765.3.fasta YKL192C ACP1 3.2E+02 0.0385 0 4.3YGR158C_Skud1019.1.fasta YGR158C MTR3 3.2E+02 0.0336 0.0019 7.3YMR205C_Skud1878.2.fasta YMR205C PFK2 3.2E+02 0.0279 0 22.6YKL190W_Skud1765.5.fasta YKL190W CNB1 3.3E+02 0.0464 0.0027 3.7YJL173C_Skud1166.3.fasta YJL173C RFA3 3.3E+02 0.0408 0.0035 3.3YPL262W_Skud302.1.fasta YPL262W FUM1 3.3E+02 0.0304 0.001 13.5YMR029C_Skud1450.5.fasta YMR029C FAR8 3.3E+02 0.029 0.0097 14.1YDL120W_Skud1471.3.fasta YDL120W YFH1 3.3E+02 0.0354 0.0082 5.2YHR057C_Skud1807.9.fasta YHR057C CPR2 3.3E+02 0.0352 0.0022 5.1

YHL032C_Skud1834.4.fasta YHL032C GUT1 3.3E+02 0.0302 0.0013 15.9YDR286C_Skud1767.4.fasta YDR286C 3.3E+02 0.0405 0.0037 3.2YOL131W_Skud2006.5.fasta YOL131W 3.3E+02 0.037 0 4.2YJL115W_Skud1217.1.fasta YJL115W ASF1 3.3E+02 0.0393 0.0042 5.8YOL058W_Skud1402.2.fasta YOL058W ARG1 3.3E+02 0.0302 0.0012 12.3YDR049W_Skud1362.2.fasta YDR049W 3.3E+02 0.0301 0.0042 13.5YMR268C_Skud2070.15.fasta YMR268C PRP24 3.3E+02 0.031 0.0053 11.4YLR394W_Skud2066.9.fasta YLR394W CST9 3.3E+02 0.03 0.0045 12.2YOR198C_Skud1770.7.fasta YOR198C BFR1 3.4E+02 0.0316 0 9.2YPL064C_Skud1974.6.fasta YPL064C CWC27 3.4E+02 0.0343 0.0059 7.5YHR089C_Skud1470.2.fasta YHR089C GAR1 3.4E+02 0.0334 0 6.1YFR003C_Skud1697.2.fasta YFR003C YPI1 3.4E+02 0.0375 0.0056 4.3YHR143W-A_Skud2014.3.fasta YHR143W-A RPC10 3.4E+02 0.0406 0 2.1YEL017W_Skud710.1.fasta YEL017W GTT3 3.4E+02 0.0328 0.0026 7.2YMR259C_Skud2070.24.fasta YMR259C 3.4E+02 0.0268 0.0093 30.8YLR313C_Skud1965.6.fasta YLR313C SPH1 3.4E+02 0.0289 0.0108 15.3YPL055C_Skud1444.3.fasta YPL055C LGE1 3.4E+02 0.0317 0.0099 9.3YDR513W_Skud1416.5.fasta YDR513W GRX2 3.5E+02 0.0373 0 4.3YLL002W_Skud1904.8.fasta YLL002W RTT109 3.5E+02 0.0296 0.0011 12.2YEL021W_Skud1858.5.fasta YEL021W URA3 3.5E+02 0.0332 0.0035 7.3YNL093W_Skud1883.6.fasta YNL093W YPT53 3.5E+02 0.0373 0.0039 5.5YLR427W_Skud1798.3.fasta YLR427W MAG2 3.5E+02 0.0284 0.0058 16.2YDL124W_Skud1786.3.fasta YDL124W 3.5E+02 0.0315 0.0058 9.3YHL015W_Skud2034.2.fasta YHL015W RPS20 3.5E+02 0.0385 0 3.2YGL100W_Skud1658.5.fasta YGL100W SEH1 3.5E+02 0.035 0 7.7YIL160C_Skud1969.8.fasta YIL160C POT1 3.5E+02 0.0317 0 10.6YGR295C_Skud1962.4.fasta YGR295C COS6 3.5E+02 0.0411 0 2.1YCL055W_Skud2065.9.fasta YCL055W KAR4 3.6E+02 0.0315 0 9.3YER062C_Skud1762.3.fasta YER062C HOR2 3.6E+02 0.0323 0 8.4YMR197C_Skud1482.1.fasta YMR197C VTI1 3.6E+02 0.0355 0.002 5.3YJR100C_Skud1794.7.fasta YJR100C AIM25 3.6E+02 0.0354 0.0068 6.6YLR368W_Skud2027.3.fasta YLR368W MDM30 3.6E+02 0.0298 0.0093 14.7YMR067C_Skud1522.4.fasta YMR067C UBX4 3.6E+02 0.0305 0.0047 11.4YKR014C_Skud2000.5.fasta YKR014C YPT52 3.6E+02 0.033 0.002 6.1YMR088C_Skud1803.5.fasta YMR088C VBA1 3.6E+02 0.0297 0.0017 13.5YOL005C_Skud992.2.fasta YOL005C RPB11 3.7E+02 0.038 0 3.2YNR040W_Skud1741.1.fasta YNR040W 3.7E+02 0.0319 0.0108 7.1YOL078W_Skud1718.5.fasta YOL078W AVO1 3.7E+02 0.0267 0.0023 23.1YFR032C_Skud1504.6.fasta YFR032C RRT5 3.7E+02 0.0325 0.0068 7.3YER021W_Skud1655.2.fasta YER021W RPN3 3.7E+02 0.029 0.0009 13.2YDR210W_Skud68.1.fasta YDR210W 3.7E+02 0 0 0.0YCL061C_Skud2065.15.fasta YCL061C MRC1 3.7E+02 0.0268 0.0047 24.3YNL110C_Skud1428.4.fasta YNL110C NOP15 3.7E+02 0.0331 0.004 5.0YMR298W_Skud757.2.fasta YMR298W LIP1 3.7E+02 0.0348 0.0069 5.3YER183C_Skud1901.5.fasta YER183C FAU1 3.8E+02 0.0349 0 6.5YDR320C-A_Skud1363.3.fasta YDR320C-A DAD4 3.8E+02 0.0359 0 3.0YLR008C_Skud2025.17.fasta YLR008C PAM18 3.8E+02 0.0343 0 5.2YMR126C_Skud2044.11.fasta YMR126C DLT1 3.8E+02 0.0333 0 7.5YPL135W_Skud2019.11.fasta YPL135W ISU1 3.8E+02 0.0358 0 4.2YKL103C_Skud2010.4.fasta YKL103C LAP4 3.8E+02 0.0293 0.0009 13.4YOL072W_Skud1443.3.fasta YOL072W THP1 3.8E+02 0.0298 0.0041 11.3YFL018C_Skud1575.3.fasta YFL018C LPD1 3.9E+02 0.0297 0.002 13.6YHR144C_Skud2014.1.fasta YHR144C DCD1 3.9E+02 0.0329 0.0066 9.9

YPR182W_Skud1438.3.fasta YPR182W SMX3 3.9E+02 0.073 0.0001 1.9YJL048C_Skud1771.3.fasta YJL048C UBX6 3.9E+02 0.0315 0.0022 8.3YDR533C_Skud2001.12.fasta YDR533C HSP31 3.9E+02 0.0329 0.0042 7.4YNR038W_Skud1741.3.fasta YNR038W DBP6 3.9E+02 0.0295 0.0028 13.6YNR004W_Skud1932.6.fasta YNR004W 3.9E+02 0.0341 0.0108 4.0YFL014W_Skud1910.8.fasta YFL014W HSP12 3.9E+02 0.0393 0.0083 3.4YBL090W_Skud1495.7.fasta YBL090W MRP21 3.9E+02 0.0375 0 4.5YDR313C_Skud781.2.fasta YDR313C PIB1 3.9E+02 0.033 0.003 7.5YGL005C_Skud1881.3.fasta YGL005C COG7 4.0E+02 0.0318 0.0067 7.2YPL051W_Skud1641.7.fasta YPL051W ARL3 4.0E+02 0.0337 0.0023 5.2YLR027C_Skud1684.3.fasta YLR027C AAT2 4.0E+02 0.03 0 10.3YBL060W_Skud1907.3.fasta YBL060W YEL1 4.0E+02 0.0288 0.0033 15.6YOL088C_Skud1391.2.fasta YOL088C MPD2 4.0E+02 0.0338 0.0114 9.0YOL049W_Skud1622.2.fasta YOL049W GSH2 4.0E+02 0.0312 0.0145 10.7YHR022C_Skud1621.4.fasta YHR022C 4.0E+02 0.0307 0.0121 10.5YDR480W_Skud1730.2.fasta YDR480W DIG2 4.1E+02 0.0353 0 3.1YER051W_Skud2039.5.fasta YER051W JHD1 4.1E+02 0.0298 0.0067 12.6YOR188W_Skud1997.4.fasta YOR188W MSB1 4.1E+02 0.0273 0.0058 23.9YGR053C_Skud2031.8.fasta YGR053C 4.1E+02 0.0314 0.0049 7.2YFR027W_Skud1288.1.fasta YFR027W ECO1 4.1E+02 0.0308 0 8.2YKR025W_Skud1613.1.fasta YKR025W RPC37 4.1E+02 0.0313 0.0051 8.4YBR039W_Skud1753.2.fasta YBR039W ATP3 4.1E+02 0.0302 0 9.2YEL036C_Skud1692.5.fasta YEL036C ANP1 4.1E+02 0.0299 0.0019 10.3YMR052W_Skud1978.5.fasta YMR052W FAR3 4.1E+02 0.0316 0.0224 6.1YOR215C_Skud1769.1.fasta YOR215C AIM41 4.2E+02 0.0329 0.0026 5.1YGL040C_Skud2052.17.fasta YGL040C HEM2 4.2E+02 0.0345 0 7.9YKL049C_Skud2056.8.fasta YKL049C CSE4 4.2E+02 0.036 0 3.2YPL267W_Skud531.2.fasta YPL267W ACM1 4.2E+02 0.0314 0.0117 6.1YOR189W_Skud1997.3.fasta YOR189W IES4 4.2E+02 0.0359 0.0038 3.2YDR132C_Skud1908.5.fasta YDR132C 4.2E+02 0.0307 0.0054 10.6YBR244W_Skud1651.3.fasta YBR244W GPX2 4.3E+02 0.038 0.0025 3.3YDR399W_Skud1573.3.fasta YDR399W HPT1 4.3E+02 0.0326 0.0022 6.3YOL114C_Skud1896.7.fasta YOL114C 4.3E+02 0.0347 0.0042 4.2YPR138C_Skud2053.9.fasta YPR138C MEP3 4.3E+02 0.0296 0 12.6YOR353C_Skud1930.6.fasta YOR353C SOG2 4.3E+02 0.0284 0.0029 17.9YHR016C_Skud2067.4.fasta YHR016C YSC84 4.3E+02 0.0303 0.0087 10.5YLR079W_Skud989.7.fasta YLR079W SIC1 4.3E+02 0.0318 0.0016 7.4YHR088W_Skud1470.3.fasta YHR088W RPF1 4.3E+02 0.0303 0 7.0YGR036C_Skud1926.5.fasta YGR036C CAX4 4.3E+02 0.0327 0.0019 6.4YGR105W_Skud2023.2.fasta YGR105W VMA21 4.4E+02 0.037 0 2.1YJL058C_Skud789.1.fasta YJL058C BIT61 4.4E+02 0.0292 0.0026 11.4YDR328C_Skud1638.2.fasta YDR328C SKP1 4.4E+02 0.0334 0 5.3YNL290W_Skud1783.7.fasta YNL290W RFC3 4.4E+02 0.0295 0 8.0YOL048C_Skud1622.3.fasta YOL048C RRT8 4.4E+02 0.0352 0.0047 3.1YKL105C_Skud2010.6.fasta YKL105C 4.4E+02 0.0284 0.0226 16.8YDR428C_Skud1634.3.fasta YDR428C BNA7 4.5E+02 0.0329 0.0064 6.5YGL221C_Skud1804.9.fasta YGL221C NIF3 4.5E+02 0.0324 0.0016 6.4_Skud1947.1.fasta 4.5E+02 0 0 0.0YIL008W_Skud1909.5.fasta YIL008W URM1 4.5E+02 0.0357 0.0049 3.2YBL029C-A_Skud2007.8.fasta YBL029C-A 4.5E+02 0.0353 0 3.2YLR343W_Skud1485.2.fasta YLR343W GAS2 4.6E+02 0.0293 0.0008 12.6YLR014C_Skud2025.11.fasta YLR014C PPR1 4.6E+02 0.0267 0.008 18.1YOR383C_Skud2036.3.fasta YOR383C FIT3 4.6E+02 0.0354 0.0023 7.0

YKR026C_Skud1613.2.fasta YKR026C GCN3 4.6E+02 0.0301 0 8.2YMR071C_Skud1528.1.fasta YMR071C TVP18 4.6E+02 0.0332 0 4.2YBR057C_Skud1976.10.fasta YBR057C MUM2 4.6E+02 0.0309 0.0026 9.7YOL133W_Skud2006.3.fasta YOL133W HRT1 4.7E+02 0.0409 0 2.4YGR126W_Skud1864.3.fasta YGR126W 4.7E+02 0.0308 0 6.1YLL018C-A_Skud1165.2.fasta YLL018C-A COX19 4.8E+02 0.0333 0.015 3.1YMR140W_Skud1802.4.fasta YMR140W SIP5 4.8E+02 0.03 0.0045 10.6YER019W_Skud1655.5.fasta YER019W ISC1 4.8E+02 0.0291 0.002 9.2YNL317W_Skud861.2.fasta YNL317W PFS2 4.8E+02 0.0311 0.0055 8.6YMR219W_Skud1734.2.fasta YMR219W ESC1 4.8E+02 0.0264 0.013 22.5YJL161W_Skud1663.5.fasta YJL161W FMP33 4.8E+02 0.0311 0.0055 5.1YPL273W_Skud2029.4.fasta YPL273W SAM4 4.8E+02 0.0309 0.0046 5.0YHR119W_Skud1988.1.fasta YHR119W SET1 4.8E+02 0.027 0.0056 21.9YMR280C_Skud2070.3.fasta YMR280C CAT8 4.8E+02 0.0257 0.0067 30.7YHR175W_Skud2046.12.fasta YHR175W CTR2 4.9E+02 0.0354 0.0077 4.5YDR284C_Skud1767.2.fasta YDR284C DPP1 4.9E+02 0.034 0.0045 6.8YMR148W_Skud1371.1.fasta YMR148W 4.9E+02 0.0329 0 4.2YFL008W_Skud1910.2.fasta YFL008W SMC1 4.9E+02 0.0349 0 2.1YLR310C_Skud1965.9.fasta YLR310C CDC25 4.9E+02 0.0256 0.0023 29.6YJR074W_Skud1916.8.fasta YJR074W MOG1 4.9E+02 0.0305 0 5.0YKL068W_Skud1840.3.fasta YKL068W NUP100 4.9E+02 0.0262 0.0093 21.3YDR175C_Skud1498.2.fasta YDR175C RSM24 4.9E+02 0.0322 0.0066 6.5YOL013C_Skud1977.5.fasta YOL013C HRD1 4.9E+02 0.0284 0.0088 13.6YHR034C_Skud1289.3.fasta YHR034C PIH1 5.0E+02 0.0318 0.0025 6.4YGL161C_Skud2042.3.fasta YGL161C YIP5 5.0E+02 0.03 0.0064 8.4YBL107C_Skud1614.2.fasta YBL107C 5.0E+02 0.0352 0 3.3YHR012W_Skud2067.9.fasta YHR012W VPS29 5.0E+02 0.0313 0.0052 5.2YIR023W_Skud1859.1.fasta YIR023W DAL81 5.0E+02 0.0271 0.0018 20.9YJL117W_Skud1091.1.fasta YJL117W PHO86 5.0E+02 0.03 0 7.2YOR039W_Skud2015.6.fasta YOR039W CKB2 5.0E+02 0.0299 0 7.2YGR016W_Skud1408.2.fasta YGR016W 5.1E+02 0.0307 0.0025 5.1YMR206W_Skud1878.1.fasta YMR206W 5.1E+02 0.0307 0.0096 6.2YGL039W_Skud2052.16.fasta YGL039W 5.1E+02 0.0327 0.0025 7.9YKR061W_Skud1873.7.fasta YKR061W KTR2 5.1E+02 0.0296 0.0021 9.5YDR159W_Skud1333.2.fasta YDR159W SAC3 5.1E+02 0.0256 0.0055 25.3YIL033C_Skud1694.3.fasta YIL033C BCY1 5.1E+02 0.0281 0 10.1YER053C_Skud2039.7.fasta YER053C PIC2 5.1E+02 0.031 0.0016 7.5YDL086W_Skud2062.5.fasta YDL086W 5.1E+02 0.0319 0 5.3YDR140W_Skud1155.3.fasta YDR140W MTQ2 5.2E+02 0.0322 0.0061 5.4YGR144W_Skud1751.2.fasta YGR144W THI4 5.2E+02 0.0305 0 8.6YPR045C_Skud1654.4.fasta YPR045C 5.2E+02 0.0279 0.0051 11.2YLR015W_Skud2025.10.fasta YLR015W BRE2 5.2E+02 0.0283 0.0038 10.2YGR067C_Skud1944.8.fasta YGR067C 5.2E+02 0.0262 0.0075 19.2_Skud1590.2.fasta 5.2E+02 0.0288 0.0017 8.1YOR186W_Skud1997.6.fasta YOR186W 5.2E+02 0.0333 0.0168 4.3YKL048C_Skud2056.7.fasta YKL048C ELM1 5.2E+02 0.0272 0.0044 14.3YLR102C_Skud1763.7.fasta YLR102C APC9 5.2E+02 0.0334 0.0063 5.6YCR069W_Skud1012.2.fasta YCR069W CPR4 5.2E+02 0.0296 0.0121 8.4YBR287W_Skud1898.3.fasta YBR287W 5.3E+02 0.0276 0 11.1YCL032W_Skud2072.13.fasta YCL032W STE50 5.3E+02 0.0321 0.0024 6.6YHR073W_Skud1817.2.fasta YHR073W OSH3 5.3E+02 0.0262 0.0014 21.5YLL021W_Skud1513.1.fasta YLL021W SPA2 5.3E+02 0.0247 0.0081 35.3YBR069C_Skud1650.3.fasta YBR069C TAT1 5.3E+02 0.0273 0.008 15.5

YNR037C_Skud1741.4.fasta YNR037C RSM19 5.3E+02 0.0338 0 2.1YPL212C_Skud1936.6.fasta YPL212C PUS1 5.3E+02 0.0281 0.0034 13.7YMR163C_Skud1551.2.fasta YMR163C INP2 5.4E+02 0.028 0.0058 12.5YHR046C_Skud1587.5.fasta YHR046C INM1 5.4E+02 0.0298 0.0017 8.5YER042W_Skud1569.2.fasta YER042W MXR1 5.4E+02 0.0315 0.0048 4.2_Skud1624.5.fasta 5.4E+02 0.0308 0.0049 7.6YLL001W_Skud1904.7.fasta YLL001W DNM1 5.4E+02 0.0272 0.0036 15.5YDR333C_Skud1750.2.fasta YDR333C 5.4E+02 0.0271 0.005 18.9YLR241W_Skud1869.4.fasta YLR241W 5.5E+02 0.0257 0.0039 19.0YGR043C_Skud1839.4.fasta YGR043C NQM1 5.5E+02 0.0289 0.0058 8.3YBR216C_Skud1523.1.fasta YBR216C YBP1 5.5E+02 0.0263 0.0029 15.0_Skud1889.4.fasta 5.5E+02 0.0344 0.0043 4.6YJL170C_Skud1241.3.fasta YJL170C ASG7 5.5E+02 0.029 0.0075 6.0YPL053C_Skud1641.9.fasta YPL053C KTR6 5.5E+02 0.0284 0.009 7.0YOR281C_Skud1737.10.fasta YOR281C PLP2 5.5E+02 0.0302 0.0033 7.5YAL007C_Skud1474.5.fasta YAL007C ERP2 5.5E+02 0.0318 0.011 6.6YHR137W_Skud2014.10.fasta YHR137W ARO9 5.6E+02 0.0276 0.0016 9.0YMR097C_Skud1727.4.fasta YMR097C MTG1 5.6E+02 0.0304 0.0023 7.5YMR095C_Skud1727.2.fasta YMR095C SNO1 5.6E+02 0.0301 0.01 4.0YMR270C_Skud2070.13.fasta YMR270C RRN9 5.6E+02 0.029 0.005 8.3YHR060W_Skud1807.6.fasta YHR060W VMA22 5.6E+02 0.0316 0.0099 4.2YDR116C_Skud1927.6.fasta YDR116C MRPL1 5.6E+02 0.0305 0 6.4YLL056C_Skud1882.8.fasta YLL056C 5.6E+02 0.0304 0.0063 7.5YEL029C_Skud1612.1.fasta YEL029C BUD16 5.6E+02 0.0292 0.003 7.2YML077W_Skud440.1.fasta YML077W BET5 5.6E+02 0.033 0.0026 3.2YOR020C_Skud1983.10.fasta YOR020C HSP10 5.7E+02 0.0346 0 2.2_Skud1710.3.fasta 5.7E+02 0.032 0.0185 2.1YGL025C_Skud2052.2.fasta YGL025C PGD1 5.7E+02 0.0294 0.0045 9.7YDL135C_Skud1961.6.fasta YDL135C RDI1 5.7E+02 0.0312 0 4.2YPL183C_Skud1462.1.fasta YPL183C RTT10 5.7E+02 0.0261 0.0032 20.6YGL211W_Skud1632.1.fasta YGL211W NCS6 5.8E+02 0.0298 0.002 5.1YOL030W_Skud2060.4.fasta YOL030W GAS5 5.8E+02 0.0289 0 10.7YNL312W_Skud1346.2.fasta YNL312W RFA2 5.8E+02 0.0307 0 3.0YKR048C_Skud1674.6.fasta YKR048C NAP1 5.8E+02 0.0321 0.002 6.8YBL091C_Skud1495.6.fasta YBL091C MAP2 5.8E+02 0.0296 0.001 8.6YBR042C_Skud1753.5.fasta YBR042C CST26 5.8E+02 0.0291 0.0045 8.4YBR237W_Skud1169.1.fasta YBR237W PRP5 5.8E+02 0.0264 0.0065 14.1YHR133C_Skud2014.14.fasta YHR133C NSG1 5.8E+02 0.029 0.0034 7.3YOL036W_Skud1723.2.fasta YOL036W 5.8E+02 0.0322 0.0088 4.4_Skud1970.4.fasta 5.9E+02 0.0346 0.0178 1.2YNL077W_Skud1628.2.fasta YNL077W APJ1 5.9E+02 0.0281 0.0017 11.6YOL008W_Skud1977.10.fasta YOL008W COQ10 5.9E+02 0.03 0 5.2YDL127W_Skud1786.6.fasta YDL127W PCL2 5.9E+02 0.0284 0 8.3_Skud1984.8.fasta 5.9E+02 0.0298 0.0193 5.2YMR022W_Skud1286.2.fasta YMR022W UBC7 5.9E+02 0.031 0.0112 4.2YOL091W_Skud1742.3.fasta YOL091W SPO21 5.9E+02 0.0274 0.0038 13.6YML071C_Skud2021.5.fasta YML071C COG8 5.9E+02 0.0272 0.0052 12.4YDL233W_Skud1254.2.fasta YDL233W 6.0E+02 0.0289 0.0039 10.8YOR066W_Skud1854.3.fasta YOR066W MSA1 6.0E+02 0.0274 0.0047 15.9YJL013C_Skud1835.8.fasta YJL013C MAD3 6.0E+02 0.0273 0.0102 11.3YDR134C_Skud1908.4.fasta YDR134C 6.0E+02 0.0299 0 4.1YBR047W_Skud1853.1.fasta YBR047W FMP23 6.1E+02 0.0338 0.0047 3.4YER085C_Skud1635.3.fasta YER085C 6.1E+02 0.0286 0.0089 5.0

YJL076W_Skud1536.2.fasta YJL076W NET1 6.1E+02 0.0252 0.0036 27.7YMR161W_Skud1956.2.fasta YMR161W HLJ1 6.1E+02 0.031 0 5.4_Skud2050.3.fasta 6.1E+02 0.033 0.0033 3.3YNR051C_Skud1826.2.fasta YNR051C BRE5 6.1E+02 0.0271 0.0113 12.4YAL036C_Skud1685.3.fasta YAL036C RBG1 6.1E+02 0.027 0 9.0YDR173C_Skud1498.4.fasta YDR173C ARG82 6.1E+02 0.0284 0.0122 8.3YOL042W_Skud1723.7.fasta YOL042W NGL1 6.1E+02 0.0313 0.0022 5.5YOR023C_Skud1983.7.fasta YOR023C AHC1 6.2E+02 0.0267 0.0018 14.5YHR138C_Skud2014.9.fasta YHR138C 6.2E+02 0.0311 0.0088 2.1YNL070W_Skud1657.4.fasta YNL070W TOM7 6.2E+02 0.033 0.0067 1.1YLR301W_Skud2059.2.fasta YLR301W 6.2E+02 0.0285 0.008 6.1YDR515W_Skud1594.6.fasta YDR515W SLF1 6.2E+02 0.0268 0.0081 12.3YGR007W_Skud1670.6.fasta YGR007W MUQ1 6.2E+02 0.0291 0.0029 7.4YHR082C_Skud1728.4.fasta YHR082C KSP1 6.2E+02 0.0258 0.0014 22.8_Skud1984.6.fasta 6.2E+02 0.0298 0 1.0YKL214C_Skud1994.7.fasta YKL214C YRA2 6.2E+02 0.0303 0.0086 4.2YOR236W_Skud1805.4.fasta YOR236W DFR1 6.2E+02 0.0288 0.0025 6.2YCR043C_Skud2040.2.fasta YCR043C 6.2E+02 0.0291 0 4.0YPR019W_Skud1887.5.fasta YPR019W MCM4 6.3E+02 0.0256 0.0014 16.1YLR199C_Skud1827.8.fasta YLR199C PBA1 6.3E+02 0.0304 0.0062 5.4_Skud1970.6.fasta 6.3E+02 0 0 0.0YAR015W_Skud604.1.fasta YAR015W ADE1 6.3E+02 0.0296 0.0058 6.4YOR108W_Skud2018.5.fasta YOR108W LEU9 6.3E+02 0.0273 0.0008 13.7YCL057W_Skud2065.11.fasta YCL057W PRD1 6.4E+02 0.0296 0.0036 5.3YBR164C_Skud1852.8.fasta YBR164C ARL1 6.4E+02 0.0296 0 4.1YDR229W_Skud2069.3.fasta YDR229W IVY1 6.4E+02 0.0277 0.0048 9.3YNR006W_Skud1932.5.fasta YNR006W VPS27 6.4E+02 0.0277 0.0035 12.8YGL096W_Skud1919.4.fasta YGL096W TOS8 6.5E+02 0.0291 0.0169 6.3YIL153W_Skud1285.2.fasta YIL153W RRD1 6.5E+02 0.027 0.0034 8.0YMR291W_Skud1793.3.fasta YMR291W TDA1 6.5E+02 0.0272 0.0024 12.6YDR372C_Skud1687.4.fasta YDR372C VPS74 6.5E+02 0.0275 0.0014 8.2YLR083C_Skud989.4.fasta YLR083C EMP70 6.5E+02 0.0265 0.0025 11.2YML072C_Skud2021.4.fasta YML072C TCB3 6.5E+02 0.0242 0.0036 30.0YHR049W_Skud1587.2.fasta YHR049W FSH1 6.5E+02 0.0288 0.002 6.3YBR059C_Skud1976.7.fasta YBR059C AKL1 6.5E+02 0.0248 0.0017 22.1YNL108C_Skud1428.3.fasta YNL108C 6.5E+02 0.0325 0 5.8YDR377W_Skud1409.3.fasta YDR377W ATP17 6.5E+02 0.0315 0 2.2_Skud1465.3.fasta 6.6E+02 0.0284 0.0067 1.0YGR286C_Skud1618.2.fasta YGR286C BIO2 6.6E+02 0.0278 0 9.4YML105C_Skud1963.11.fasta YML105C SEC65 6.6E+02 0.0296 0.01 6.5YGR104C_Skud1325.5.fasta YGR104C SRB5 6.6E+02 0.0299 0.0138 5.4YDR258C_Skud2012.2.fasta YDR258C HSP78 6.6E+02 0.0268 0.0018 17.0YPL113C_Skud1951.2.fasta YPL113C 6.6E+02 0.0277 0.0024 9.4YML032C_Skud1957.3.fasta YML032C RAD52 6.6E+02 0.0289 0.0018 8.7_Skud1996.6.fasta 6.7E+02 0.0279 0.0167 9.5YBL041W_Skud1851.4.fasta YBL041W PRE7 6.7E+02 0.0282 0.002 6.2YGR119C_Skud1724.4.fasta YGR119C NUP57 6.7E+02 0.0269 0.0078 11.4YOR372C_Skud1260.1.fasta YOR372C NDD1 6.7E+02 0.0269 0.0035 12.5YLR277C_Skud1933.6.fasta YLR277C YSH1 6.7E+02 0.0265 0.0036 16.9YPL260W_Skud302.2.fasta YPL260W 6.7E+02 0.027 0.0024 10.3YML080W_Skud1623.4.fasta YML080W DUS1 6.7E+02 0.0306 0.0057 3.2YLR281C_Skud2059.20.fasta YLR281C 6.8E+02 0.0288 0.0024 4.1_Skud1231.2.fasta 6.8E+02 0.0296 0.0062 1.1

YHR033W_Skud1289.4.fasta YHR033W 6.8E+02 0.0271 0.0019 8.2YNL204C_Skud1680.2.fasta YNL204C SPS18 6.8E+02 0.0291 0.0059 6.4YNL282W_Skud764.1.fasta YNL282W POP3 6.8E+02 0.0344 0.0094 4.9YML087C_Skud1488.2.fasta YML087C AIM33 6.8E+02 0.0271 0.0045 7.1YNL075W_Skud955.1.fasta YNL075W IMP4 6.8E+02 0.0278 0 6.2YHR160C_Skud1735.5.fasta YHR160C PEX18 6.9E+02 0.0287 0.0082 6.4YGL192W_Skud1705.2.fasta YGL192W IME4 6.9E+02 0.0257 0.0024 13.1YER052C_Skud2039.6.fasta YER052C HOM3 6.9E+02 0.0263 0 12.3YNL136W_Skud1855.2.fasta YNL136W EAF7 6.9E+02 0.0272 0.0087 9.3YGL059W_Skud1952.1.fasta YGL059W PKP2 6.9E+02 0.0277 0.0009 9.5YHR135C_Skud2014.12.fasta YHR135C YCK1 6.9E+02 0.0268 0.0036 11.4YOL115W_Skud1896.8.fasta YOL115W PAP2 6.9E+02 0.0266 0.0022 11.4_Skud1990.8.fasta 6.9E+02 0.027 0 1.0YDL006W_Skud1672.2.fasta YDL006W PTC1 7.0E+02 0.0287 0 6.4YDR272W_Skud1845.2.fasta YDR272W GLO2 7.0E+02 0.0293 0.0095 5.4YJL144W_Skud2041.11.fasta YJL144W 7.0E+02 0.0298 0.0044 3.2YNR002C_Skud1932.8.fasta YNR002C ATO2 7.0E+02 0.0294 0.0032 6.6YHR115C_Skud2024.4.fasta YHR115C DMA1 7.0E+02 0.0278 0.0023 9.6YCR061W_Skud2008.8.fasta YCR061W 7.0E+02 0.027 0.0057 10.4_Skud1990.10.fasta 7.0E+02 0.0289 0.0085 2.1YJL160C_Skud1663.4.fasta YJL160C 7.0E+02 0.0278 0.0088 6.2YPR137W_Skud2053.7.fasta YPR137W RRP9 7.1E+02 0.0277 0.0015 10.7YKL114C_Skud2020.9.fasta YKL114C APN1 7.1E+02 0.0269 0.0039 8.2YOL111C_Skud1896.4.fasta YOL111C MDY2 7.1E+02 0.0524 0.0069 2.0YJL159W_Skud1663.3.fasta YJL159W HSP150 7.1E+02 0.0266 0.0042 9.2YNL260C_Skud1199.3.fasta YNL260C 7.1E+02 0.0285 0.0061 4.2YPL158C_Skud2033.10.fasta YPL158C AIM44 7.1E+02 0.0261 0.0059 16.8YAL009W_Skud1474.3.fasta YAL009W SPO7 7.1E+02 0.0276 0.0019 6.2YNR064C_Skud1943.9.fasta YNR064C 7.1E+02 0.0275 0.0067 7.3_Skud1902.3.fasta 7.1E+02 0.0266 0 1.0YBR234C_Skud1458.4.fasta YBR234C ARC40 7.1E+02 0.0276 0.0024 8.4YNL308C_Skud1519.1.fasta YNL308C KRI1 7.2E+02 0.0258 0.005 13.3YBR012C_Skud1144.2.fasta YBR012C 7.2E+02 0.026 0 1.0YBR013C_Skud1144.1.fasta YBR013C 7.2E+02 0.026 0 1.0_Skud2048.2.fasta 7.2E+02 0.0289 0.0142 4.2YJL121C_Skud1257.2.fasta YJL121C RPE1 7.2E+02 0.0293 0 5.4YMR214W_Skud1400.2.fasta YMR214W SCJ1 7.3E+02 0.028 0.0012 7.5YOL101C_Skud1755.5.fasta YOL101C IZH4 7.3E+02 0.0278 0.0038 7.4YKL069W_Skud1840.1.fasta YKL069W 7.3E+02 0.0288 0.0026 4.2YCL031C_Skud2072.14.fasta YCL031C RRP7 7.3E+02 0.0295 0.0028 5.5_Skud731.2.fasta 7.3E+02 0.0277 0.0168 3.0YNL103W_Skud1879.3.fasta YNL103W MET4 7.4E+02 0.0261 0.0081 13.5YLL049W_Skud1624.2.fasta YLL049W LDB18 7.4E+02 0.0318 0 5.9YER002W_Skud1819.3.fasta YER002W NOP16 7.4E+02 0.0276 0.0019 5.2YHR058C_Skud1807.8.fasta YHR058C MED6 7.4E+02 0.0277 0.0046 6.3YNL265C_Skud1368.2.fasta YNL265C IST1 7.4E+02 0.0272 0.0015 5.1YOL018C_Skud2060.16.fasta YOL018C TLG2 7.4E+02 0.0272 0.0045 8.4YIL125W_Skud2022.5.fasta YIL125W KGD1 7.4E+02 0.0253 0.0009 19.7YBR152W_Skud2051.7.fasta YBR152W SPP381 7.5E+02 0.0278 0.003 5.2YPL230W_Skud1090.1.fasta YPL230W USV1 7.5E+02 0.027 0.0025 10.6YDR285W_Skud1767.3.fasta YDR285W ZIP1 7.5E+02 0.0246 0.0063 17.0YOR361C_Skud2013.10.fasta YOR361C PRT1 7.5E+02 0.0287 0.0213 3.2YDL205C_Skud1850.5.fasta YDL205C HEM3 7.5E+02 0.026 0.0031 8.0

_Skud1142.1.fasta 7.5E+02 0.029 0.0122 1.1YIL161W_Skud1969.7.fasta YIL161W 7.5E+02 0.0277 0.0019 5.2YKL002W_Skud1788.8.fasta YKL002W DID4 7.5E+02 0.0296 0.0034 4.4YKR097W_Skud2028.3.fasta YKR097W PCK1 7.5E+02 0.027 0.0009 12.9YLR239C_Skud1869.2.fasta YLR239C LIP2 7.6E+02 0.0271 0.0043 7.3YML106W_Skud1963.10.fasta YML106W URA5 7.6E+02 0.0267 0 6.1YDR329C_Skud1638.3.fasta YDR329C PEX3 7.6E+02 0.0263 0.0088 9.3YJL062W-A_Skud1625.2.fasta YJL062W-A 7.6E+02 0.0275 0 1.1_Skud1984.4.fasta 7.6E+02 0.0269 0.0062 1.1YKL140W_Skud1823.7.fasta YKL140W TGL1 7.6E+02 0.0254 0.0019 14.3YKL117W_Skud2020.7.fasta YKL117W SBA1 7.6E+02 0.03 0.0038 5.7YML125C_Skud1995.11.fasta YML125C PGA3 7.6E+02 0.0266 0.0077 7.2YHR151C_Skud1820.5.fasta YHR151C MTC6 7.7E+02 0.0262 0.0026 10.3YLR411W_Skud1928.2.fasta YLR411W CTR3 7.7E+02 0.0276 0 5.2YBR177C_Skud1973.3.fasta YBR177C EHT1 7.7E+02 0.0274 0.0019 8.5YOR154W_Skud1201.2.fasta YOR154W SLP1 7.7E+02 0.0253 0.005 13.2YPR109W_Skud1473.1.fasta YPR109W 7.7E+02 0.0281 0.0125 4.2YOR230W_Skud1394.2.fasta YOR230W WTM1 7.8E+02 0.0265 0 10.5YFL002C_Skud1697.6.fasta YFL002C SPB4 7.8E+02 0.0271 0.0042 10.7YDL065C_Skud1991.7.fasta YDL065C PEX19 7.8E+02 0.0263 0.0042 8.2YMR144W_Skud1802.7.fasta YMR144W 7.8E+02 0.0262 0.008 9.3YOR120W_Skud1746.3.fasta YOR120W GCY1 7.8E+02 0.0293 0.004 5.6YBR217W_Skud1523.2.fasta YBR217W ATG12 7.9E+02 0.029 0.005 4.4YJL192C_Skud1987.5.fasta YJL192C SOP4 7.9E+02 0.0273 0.0061 5.2YMR194W_Skud1752.3.fasta YMR194W RPL36A 7.9E+02 0.0269 0 2.0YGL082W_Skud2057.3.fasta YGL082W 7.9E+02 0.0296 0.001 5.7YOR222W_Skud1729.2.fasta YOR222W ODC2 7.9E+02 0.0269 0 7.3YCL037C_Skud2072.8.fasta YCL037C SRO9 7.9E+02 0.0265 0.0058 10.5YMR099C_Skud1727.7.fasta YMR099C 7.9E+02 0.0273 0.0031 6.3YMR118C_Skud2044.3.fasta YMR118C 8.0E+02 0.0275 0.0026 5.3YER182W_Skud1901.4.fasta YER182W FMP10 8.0E+02 0.0266 0 5.1YER159C_Skud2047.8.fasta YER159C BUR6 8.0E+02 0.0291 0.0031 3.3YJR129C_Skud1503.3.fasta YJR129C 8.0E+02 0.0276 0.0104 6.4YDR156W_Skud711.3.fasta YDR156W RPA14 8.0E+02 0.0283 0.0033 2.2YLR268W_Skud1237.1.fasta YLR268W SEC22 8.1E+02 0.0282 0 4.3YDR369C_Skud1699.2.fasta YDR369C XRS2 8.1E+02 0.0248 0.0114 15.2YDL201W_Skud1535.6.fasta YDL201W TRM8 8.1E+02 0.0279 0.0015 5.4YNR063W_Skud1943.8.fasta YNR063W 8.1E+02 0.0267 0.0076 5.2YGL032C_Skud2052.9.fasta YGL032C AGA2 8.1E+02 0.0276 0.0113 2.1YGL075C_Skud2057.10.fasta YGL075C MPS2 8.2E+02 0.0257 0.0085 8.1YDL051W_Skud1196.1.fasta YDL051W LHP1 8.2E+02 0.0269 0 5.2YMR073C_Skud1528.3.fasta YMR073C IRC21 8.2E+02 0.0268 0 4.1YDL198C_Skud1535.3.fasta YDL198C GGC1 8.2E+02 0.0268 0.0015 6.3YDL128W_Skud1786.7.fasta YDL128W VCX1 8.2E+02 0.0259 0.0024 9.3YGL122C_Skud2026.14.fasta YGL122C NAB2 8.3E+02 0.0275 0.0034 8.7YHR189W_Skud1553.4.fasta YHR189W PTH1 8.3E+02 0.0266 0.0024 4.1YKL067W_Skud1840.4.fasta YKL067W YNK1 8.3E+02 0.0275 0.0029 3.2YGL215W_Skud1632.4.fasta YGL215W CLG1 8.3E+02 0.0254 0.0069 10.2YMR098C_Skud1727.5.fasta YMR098C ATP25 8.3E+02 0.0249 0.0068 12.2YOR327C_Skud1405.2.fasta YOR327C SNC2 8.3E+02 0.0285 0 2.2YBL016W_Skud1914.2.fasta YBL016W FUS3 8.4E+02 0.0275 0.0012 5.4YBR033W_Skud1675.3.fasta YBR033W EDS1 8.4E+02 0.0248 0.0118 18.6YAL028W_Skud1181.2.fasta YAL028W FRT2 8.5E+02 0.0253 0.0057 12.4

YOR360C_Skud2013.11.fasta YOR360C PDE2 8.5E+02 0.026 0.0095 10.5_Skud1996.10.fasta 8.5E+02 0 0 0.0YDL074C_Skud2062.18.fasta YDL074C BRE1 8.5E+02 0.0252 0.0028 15.7YEL044W_Skud1931.3.fasta YEL044W IES6 8.5E+02 0.0333 0.0055 3.9YPR004C_Skud1441.2.fasta YPR004C AIM45 8.6E+02 0.0259 0.0027 7.2YHR188C_Skud1553.3.fasta YHR188C GPI16 8.6E+02 0.0257 0.0025 14.9YGL209W_Skud1253.2.fasta YGL209W MIG2 8.6E+02 0.0277 0.0072 8.9YLR221C_Skud1998.8.fasta YLR221C RSA3 8.6E+02 0.0279 0.0039 4.4YLR021W_Skud2025.4.fasta YLR021W IRC25 8.6E+02 0.0269 0.0054 4.2YGL194C_Skud1705.3.fasta YGL194C HOS2 8.6E+02 0.0257 0.001 9.3YBR256C_Skud2064.17.fasta YBR256C RIB5 8.6E+02 0.0263 0.0022 6.3YKL205W_Skud1772.3.fasta YKL205W LOS1 8.7E+02 0.0263 0.0048 8.5YBR142W_Skud2051.16.fasta YBR142W MAK5 8.7E+02 0.0255 0.0052 8.2YDR458C_Skud1572.2.fasta YDR458C HEH2 8.7E+02 0.0244 0.0112 13.1YPL003W_Skud1777.4.fasta YPL003W ULA1 8.7E+02 0.0248 0.0049 10.1YKR060W_Skud1873.6.fasta YKR060W UTP30 8.7E+02 0.0267 0.0048 5.3YKL026C_Skud1981.2.fasta YKL026C GPX1 8.7E+02 0.0259 0.0058 4.1YDR262W_Skud2012.6.fasta YDR262W 8.7E+02 0.0267 0.012 5.3YKL195W_Skud365.1.fasta YKL195W MIA40 8.7E+02 0.0261 0.0127 8.4YMR006C_Skud2043.14.fasta YMR006C PLB2 8.8E+02 0.0247 0.002 15.4_Skud1599.4.fasta 8.8E+02 0.0233 0.0151 1.0YER080W_Skud1738.4.fasta YER080W AIM9 8.8E+02 0.0256 0.0029 12.7YPR147C_Skud2053.16.fasta YPR147C 8.8E+02 0.026 0.0065 7.3YML128C_Skud1995.8.fasta YML128C MSC1 8.8E+02 0.0253 0.0017 8.2YOR190W_Skud1997.2.fasta YOR190W SPR1 8.8E+02 0.0261 0.0042 9.5YBR085C-A_Skud2011.10.fasta YBR085C-A 8.8E+02 0.0244 0 1.1YNL240C_Skud1579.3.fasta YNL240C NAR1 8.9E+02 0.0251 0.0056 9.2YPL200W_Skud1659.5.fasta YPL200W CSM4 8.9E+02 0.0266 0.0057 3.2YGL029W_Skud2052.6.fasta YGL029W CGR1 8.9E+02 0.0342 0.0151 2.8YHR201C_Skud1913.7.fasta YHR201C PPX1 8.9E+02 0.0255 0.0095 8.3YOR352W_Skud1930.7.fasta YOR352W 8.9E+02 0.025 0.0029 8.1YML023C_Skud2017.5.fasta YML023C NSE5 8.9E+02 0.0254 0.0056 10.4YFR030W_Skud1581.2.fasta YFR030W MET10 8.9E+02 0.0249 0.005 7.0YLR274W_Skud1933.3.fasta YLR274W MCM5 8.9E+02 0.0242 0.0014 15.2YOR226C_Skud1729.5.fasta YOR226C ISU2 8.9E+02 0.0268 0 3.2YJL194W_Skud1987.3.fasta YJL194W CDC6 8.9E+02 0.0246 0.0047 11.1YER031C_Skud1757.5.fasta YER031C YPT31 9.0E+02 0.0253 0.0044 5.1YPR156C_Skud1502.2.fasta YPR156C TPO3 9.0E+02 0.0269 0.0178 2.2YJR046W_Skud1126.2.fasta YJR046W TAH11 9.0E+02 0.0301 0.0025 4.8YOL071W_Skud1443.4.fasta YOL071W EMI5 9.0E+02 0.0295 0 4.7YDL169C_Skud1601.1.fasta YDL169C UGX2 9.0E+02 0.0267 0.004 4.3YKL133C_Skud1555.2.fasta YKL133C 9.0E+02 0.0248 0.0053 10.2YER100W_Skud2009.6.fasta YER100W UBC6 9.0E+02 0.0254 0 6.1YDL139C_Skud1961.2.fasta YDL139C SCM3 9.0E+02 0.027 0.0074 3.2YGL242C_Skud1407.2.fasta YGL242C 9.1E+02 0.0256 0.0052 4.1YPL258C_Skud302.4.fasta YPL258C THI21 9.1E+02 0.025 0.0054 12.5YLL006W_Skud1676.1.fasta YLL006W MMM1 9.1E+02 0.0256 0.0054 8.3YBR086C_Skud2011.9.fasta YBR086C IST2 9.1E+02 0.024 0.0074 20.4_Skud2016.5.fasta 9.1E+02 0 0 0.0YLR318W_Skud1965.2.fasta YLR318W EST2 9.1E+02 0.0257 0.0103 1.2YGR035C_Skud1926.4.fasta YGR035C 9.1E+02 0.0283 0 2.3_Skud1727.6.fasta 9.1E+02 0.0263 0.0209 5.3YER094C_Skud2009.11.fasta YER094C PUP3 9.1E+02 0.025 0 5.0

YOR228C_Skud1729.7.fasta YOR228C 9.1E+02 0.0259 0.0016 7.4YPL010W_Skud1619.3.fasta YPL010W RET3 9.1E+02 0.0255 0.0025 4.1YGR040W_Skud1839.7.fasta YGR040W KSS1 9.1E+02 0.0258 0 8.4YJL206C_Skud1389.2.fasta YJL206C 9.2E+02 0.0256 0.0141 2.1YDR276C_Skud1845.5.fasta YDR276C PMP3 9.2E+02 0.0235 0.0085 1.1YDL020C_Skud1867.8.fasta YDL020C RPN4 9.2E+02 0.0254 0.0034 10.5YJR039W_Skud1706.2.fasta YJR039W 9.2E+02 0.0239 0.0079 23.6YBR201W_Skud1989.11.fasta YBR201W DER1 9.2E+02 0.0264 0.0021 4.3YBR030W_Skud2061.7.fasta YBR030W RKM3 9.2E+02 0.0266 0.003 9.9YBR132C_Skud1937.7.fasta YBR132C AGP2 9.3E+02 0.0249 0.0024 12.5YMR281W_Skud2070.2.fasta YMR281W GPI12 9.3E+02 0.0249 0.0047 6.1YPL048W_Skud1641.4.fasta YPL048W CAM1 9.3E+02 0.0265 0.0034 7.6YDR084C_Skud1929.5.fasta YDR084C TVP23 9.3E+02 0.0252 0.0047 6.1YDR006C_Skud1100.5.fasta YDR006C SOK1 9.3E+02 0.028 0.0157 2.3YLR226W_Skud1998.3.fasta YLR226W BUR2 9.3E+02 0.0251 0.0024 8.2_Skud1549.3.fasta 9.3E+02 0.0243 0.0075 2.0YOR194C_Skud1770.3.fasta YOR194C TOA1 9.3E+02 0.026 0.003 4.2YPR061C_Skud1546.4.fasta YPR061C JID1 9.4E+02 0.0246 0.0118 7.1YJR103W_Skud1794.4.fasta YJR103W URA8 9.4E+02 0.0252 0.0024 11.6YNL156C_Skud1023.1.fasta YNL156C NSG2 9.4E+02 0.0246 0 6.0YCR045C_Skud1526.4.fasta YCR045C RRT12 9.4E+02 0.0247 0.006 10.3YLR446W_Skud1816.1.fasta YLR446W 9.4E+02 0.0255 0.001 8.4YDR036C_Skud2038.10.fasta YDR036C EHD3 9.4E+02 0.0253 0.0047 10.5YBR049C_Skud1233.1.fasta YBR049C REB1 9.5E+02 0.0243 0.0018 17.6YPR093C_Skud1982.11.fasta YPR093C ASR1 9.5E+02 0.0256 0.0015 5.2YPR120C_Skud1617.4.fasta YPR120C CLB5 9.5E+02 0.0258 0.003 8.5YNL284C_Skud1837.4.fasta YNL284C MRPL10 9.5E+02 0.0275 0.0016 6.8YGR207C_Skud1744.4.fasta YGR207C 9.5E+02 0.0253 0.0017 5.2YBR107C_Skud963.1.fasta YBR107C IML3 9.5E+02 0.025 0 5.1YCR088W_Skud1764.7.fasta YCR088W ABP1 9.5E+02 0.0255 0.0041 12.8YPL269W_Skud2029.8.fasta YPL269W KAR9 9.5E+02 0.0254 0.0082 13.9YLR245C_Skud1869.8.fasta YLR245C CDD1 9.5E+02 0.0263 0.0033 3.2YPR159W_Skud1870.3.fasta YPR159W KRE6 9.6E+02 0.0253 0.0006 12.8YPL223C_Skud1934.3.fasta YPL223C GRE1 9.6E+02 0.0296 0.0078 4.8YNL050C_Skud1564.5.fasta YNL050C 9.6E+02 0.0266 0.0056 4.3YCL016C_Skud2072.26.fasta YCL016C DCC1 9.6E+02 0.0246 0.0101 8.1YFR033C_Skud1504.4.fasta YFR033C QCR6 9.6E+02 0.0244 0.0033 2.1YER139C_Skud1720.2.fasta YER139C RTR1 9.6E+02 0.0282 0.0018 3.5YOL032W_Skud2060.2.fasta YOL032W OPI10 9.6E+02 0.0255 0.0019 5.2YIL137C_Skud1832.7.fasta YIL137C TMA108 9.7E+02 0.0252 0.0062 7.3YDL182W_Skud2045.10.fasta YDL182W LYS20 9.7E+02 0.0246 0 5.0YDL244W_Skud1610.2.fasta YDL244W THI13 9.7E+02 0 0 0.0YKR019C_Skud2000.10.fasta YKR019C IRS4 9.7E+02 0.0245 0.0038 12.4YHR153C_Skud1820.7.fasta YHR153C SPO16 9.7E+02 0.0245 0.019 5.0YLR148W_Skud1736.4.fasta YLR148W PEP3 9.7E+02 0.0244 0.0024 15.6YLR209C_Skud1821.6.fasta YLR209C PNP1 9.7E+02 0.0248 0 6.1YJL187C_Skud1987.9.fasta YJL187C SWE1 9.7E+02 0.0245 0.0028 14.6YPL116W_Skud1951.4.fasta YPL116W HOS3 9.8E+02 0.025 0.0028 16.0YNL053W_Skud1564.2.fasta YNL053W MSG5 9.8E+02 0.0252 0.0078 10.6YLR190W_Skud2032.2.fasta YLR190W MMR1 9.8E+02 0.0242 0.0063 11.2YGL141W_Skud1895.8.fasta YGL141W HUL5 9.9E+02 0.0236 0.0028 14.1YGR234W_Skud1935.7.fasta YGR234W YHB1 9.9E+02 0.0232 0.0419 1.1YJR138W_Skud1942.8.fasta YJR138W IML1 9.9E+02 0.0237 0.0005 24.7

YPL057C_Skud1444.2.fasta YPL057C SUR1 9.9E+02 0.026 0.0081 9.8YKL025C_Skud1981.3.fasta YKL025C PAN3 9.9E+02 0.0255 0.0013 13.0YDR179C_Skud1051.2.fasta YDR179C CSN9 9.9E+02 0.0254 0.0131 4.2YPL174C_Skud1669.1.fasta YPL174C NIP100 9.9E+02 0.0244 0.006 14.6YMR093W_Skud1315.2.fasta YMR093W UTP15 9.9E+02 0.025 0 9.4YBL001C_Skud1586.4.fasta YBL001C ECM15 9.9E+02 0.0228 0 1.1YKR015C_Skud2000.6.fasta YKR015C 9.9E+02 0.0251 0.0041 11.7YOR124C_Skud1941.2.fasta YOR124C UBP2 1.0E+03 0.024 0.001 21.8YJR057W_Skud1911.1.fasta YJR057W CDC8 1.0E+03 0.0246 0.002 6.1YOL110W_Skud1896.3.fasta YOL110W SHR5 1.0E+03 0.0248 0.0081 5.1YDL220C_Skud1815.8.fasta YDL220C CDC13 1.0E+03 0.0238 0.0129 18.4YML078W_Skud562.1.fasta YML078W CPR3 1.0E+03 0.0251 0 5.2YGL015C_Skud1875.8.fasta YGL015C 1.0E+03 0.0245 0.0066 2.1YGR003W_Skud1329.2.fasta YGR003W CUL3 1.0E+03 0.0248 0.0049 14.8YBL095W_Skud1495.2.fasta YBL095W 1.0E+03 0.024 0.0056 6.0YLR057W_Skud1993.11.fasta YLR057W 1.0E+03 0.024 0.0039 17.6YPL228W_Skud1934.8.fasta YPL228W CET1 1.0E+03 0.0248 0.0052 10.5YBL057C_Skud1907.7.fasta YBL057C PTH2 1.0E+03 0.0247 0 5.1YKL029C_Skud1591.3.fasta YKL029C MAE1 1.0E+03 0.0239 0.0021 13.3YPR174C_Skud1422.2.fasta YPR174C 1.0E+03 0.0245 0.0025 6.1YIR010W_Skud1884.2.fasta YIR010W DSN1 1.0E+03 0.0251 0.0035 8.4YIL117C_Skud1925.4.fasta YIL117C PRM5 1.0E+03 0.0253 0.0062 7.4YPL034W_Skud1118.1.fasta YPL034W 1.0E+03 0.0252 0 2.2YBR248C_Skud2064.26.fasta YBR248C HIS7 1.0E+03 0.0246 0.0025 10.4YLR371W_Skud2027.6.fasta YLR371W ROM2 1.0E+03 0.0235 0.0017 25.7YPR167C_Skud1949.7.fasta YPR167C MET16 1.0E+03 0.0245 0.0035 5.1YBR156C_Skud2051.3.fasta YBR156C SLI15 1.0E+03 0.0245 0.0055 14.7YLR227C_Skud1998.2.fasta YLR227C ADY4 1.0E+03 0.0242 0.0078 10.3YNL036W_Skud1809.2.fasta YNL036W NCE103 1.0E+03 0.0248 0.004 4.2YGR235C_Skud1935.6.fasta YGR235C 1.0E+03 0.0249 0.0039 4.2YJR056C_Skud1317.2.fasta YJR056C 1.0E+03 0.0256 0 3.3YLL027W_Skud1745.2.fasta YLL027W ISA1 1.0E+03 0.0247 0.0076 5.2YGR236C_Skud1935.5.fasta YGR236C SPG1 1.0E+03 0.0248 0.0052 2.2YCR020W-B_Skud2048.6.fasta YCR020W-B HTL1 1.0E+03 0.022 0.0054 1.1YMR063W_Skud959.2.fasta YMR063W RIM9 1.0E+03 0.0247 0.002 5.2YJR117W_Skud1903.10.fasta YJR117W STE24 1.0E+03 0.0259 0 8.8YER027C_Skud1757.1.fasta YER027C GAL83 1.0E+03 0.026 0.0031 7.7YGR057C_Skud2031.4.fasta YGR057C LST7 1.0E+03 0.0259 0 4.4YHR008C_Skud2067.13.fasta YHR008C SOD2 1.0E+03 0.0241 0 5.1YPR113W_Skud1431.2.fasta YPR113W PIS1 1.0E+03 0.0257 0.0019 3.3YJL203W_Skud1200.2.fasta YJL203W PRP21 1.0E+03 0.0247 0.0064 5.2_Skud1177.2.fasta 1.0E+03 0.0238 0 2.1YOR261C_Skud1703.8.fasta YOR261C RPN8 1.0E+03 0.0242 0.0027 6.1YKL093W_Skud1258.3.fasta YKL093W MBR1 1.0E+03 0.0268 0.0118 7.9YMR136W_Skud1828.1.fasta YMR136W GAT2 1.0E+03 0.0241 0.0042 12.4YBR111C_Skud1877.5.fasta YBR111C YSA1 1.0E+03 0.0249 0.0062 5.3_Skud2011.11.fasta 1.0E+03 0.0247 0.0098 6.3YJL053W_Skud1556.3.fasta YJL053W PEP8 1.0E+03 0.0244 0.0026 8.3YGR094W_Skud1968.7.fasta YGR094W VAS1 1.0E+03 0.0232 0.0008 18.2YDR297W_Skud2003.4.fasta YDR297W SUR2 1.0E+03 0.0247 0.0029 8.4YBR005W_Skud1395.1.fasta YBR005W RCR1 1.1E+03 0.0246 0.0087 4.2YOR044W_Skud2015.10.fasta YOR044W IRC23 1.1E+03 0.0241 0.0029 3.1YKL055C_Skud2056.14.fasta YKL055C OAR1 1.1E+03 0.0253 0.0082 5.4

YHR177W_Skud2046.10.fasta YHR177W 1.1E+03 0.0248 0.0052 9.5YPL241C_Skud1905.4.fasta YPL241C CIN2 1.1E+03 0.0243 0.0141 2.2YLR332W_Skud2002.7.fasta YLR332W MID2 1.1E+03 0.024 0 9.2YBR269C_Skud2064.5.fasta YBR269C FMP21 1.1E+03 0.0242 0 2.1YIR001C_Skud1595.2.fasta YIR001C SGN1 1.1E+03 0.0248 0.0038 5.3YJR014W_Skud1955.2.fasta YJR014W TMA22 1.1E+03 0.0274 0.0026 5.8YKR035W-A_Skud1606.4.fasta YKR035W-A DID2 1.1E+03 0.0256 0 3.3YCR018C_Skud2048.1.fasta YCR018C SRD1 1.1E+03 0.0241 0.0102 4.1YHR140W_Skud2014.7.fasta YHR140W 1.1E+03 0.0239 0.0019 4.1YIL040W_Skud1799.4.fasta YIL040W APQ12 1.1E+03 0.0282 0 4.8YPL004C_Skud1777.3.fasta YPL004C LSP1 1.1E+03 0.0252 0 6.4YBR204C_Skud1766.4.fasta YBR204C 1.1E+03 0.0241 0.0079 8.2YOR184W_Skud1997.8.fasta YOR184W SER1 1.1E+03 0.0242 0.0012 7.2YPL272C_Skud2029.5.fasta YPL272C 1.1E+03 0.0253 0.0016 8.7YOR285W_Skud1737.6.fasta YOR285W 1.1E+03 0.0239 0 3.1YGR078C_Skud1797.2.fasta YGR078C PAC10 1.1E+03 0.0242 0.002 2.2YHR108W_Skud2024.11.fasta YHR108W GGA2 1.1E+03 0.0241 0.0032 11.5YDR487C_Skud975.2.fasta YDR487C RIB3 1.1E+03 0.0246 0.0022 4.2YGR264C_Skud1748.2.fasta YGR264C MES1 1.1E+03 0.0235 0.0013 15.4YNL097C_Skud1906.6.fasta YNL097C PHO23 1.1E+03 0.0245 0.0014 5.3YHR005C-A_Skud2067.16.fasta YHR005C-A TIM10 1.1E+03 0.0232 0 2.1YPL092W_Skud2058.10.fasta YPL092W SSU1 1.1E+03 0.0243 0.0031 9.4YBR098W_Skud1637.6.fasta YBR098W MMS4 1.1E+03 0.0242 0.0046 11.5YBR100W_Skud1637.4.fasta YBR100W 1.1E+03 0.0242 0.0046 11.5YJL011C_Skud1835.11.fasta YJL011C RPC17 1.1E+03 0.0242 0.0032 4.2YPL089C_Skud2058.13.fasta YPL089C RLM1 1.1E+03 0.0245 0.0042 12.8YGR205W_Skud1744.2.fasta YGR205W TDA10 1.1E+03 0.0242 0 5.2YOL065C_Skud1534.2.fasta YOL065C INP54 1.1E+03 0.0237 0.004 9.2YCR021C_Skud2048.7.fasta YCR021C HSP30 1.1E+03 0.025 0 6.4YGL097W_Skud1919.5.fasta YGL097W SRM1 1.1E+03 0.0243 0.0038 9.5YBR167C_Skud1973.12.fasta YBR167C POP7 1.1E+03 0.0225 0.0065 2.0YGR273C_Skud680.2.fasta YGR273C IBI1 1.1E+03 0.0242 0.0087 3.2YOR313C_Skud1795.5.fasta YOR313C SPS4 1.1E+03 0.0238 0.011 6.2YNR062C_Skud1943.7.fasta YNR062C 1.1E+03 0.0247 0.0088 7.5YFL029C_Skud1145.2.fasta YFL029C CAK1 1.1E+03 0.0254 0.0012 6.6YMR204C_Skud1878.3.fasta YMR204C INP1 1.1E+03 0.024 0.0012 8.3YIR030C_Skud1859.8.fasta YIR030C DCG1 1.1E+03 0.0245 0.0054 4.3YDR282C_Skud1845.11.fasta YDR282C 1.1E+03 0.0237 0.0098 7.2YDR362C_Skud1964.7.fasta YDR362C TFC6 1.1E+03 0.0251 0.0045 10.9YOL109W_Skud1896.2.fasta YOL109W ZEO1 1.1E+03 0.0192 0.0035 1.0YFR045W_Skud1972.10.fasta YFR045W 1.1E+03 0.024 0.0088 6.2YIL096C_Skud1344.3.fasta YIL096C 1.1E+03 0.0236 0.0014 6.1YLR346C_Skud1302.2.fasta YLR346C 1.1E+03 0.0224 0.0099 2.1YJL103C_Skud1954.8.fasta YJL103C GSM1 1.1E+03 0.0236 0.0037 12.4YAL042W_Skud848.2.fasta YAL042W ERV46 1.1E+03 0.0245 0 5.3YMR278W_Skud2070.5.fasta YMR278W PGM3 1.1E+03 0.0246 0.0076 12.9YMR147W_Skud1371.2.fasta YMR147W 1.1E+03 0.0244 0.0019 3.2YHL040C_Skud1947.4.fasta YHL040C ARN1 1.1E+03 0.024 0.0015 12.6YJL073W_Skud1221.3.fasta YJL073W JEM1 1.1E+03 0.0233 0.0074 9.1YOR077W_Skud1829.7.fasta YOR077W RTS2 1.1E+03 0.0237 0 4.1YGL155W_Skud2042.10.fasta YGL155W CDC43 1.1E+03 0.024 0.0061 7.3YGR263C_Skud1748.3.fasta YGR263C SAY1 1.1E+03 0.0242 0.0046 9.5YBR185C_Skud1785.3.fasta YBR185C MBA1 1.1E+03 0.0237 0 5.2

_Skud1886.4.fasta 1.1E+03 0.024 0.0046 13.7YIL014C-A_Skud1960.4.fasta YIL014C-A 1.1E+03 0.0209 0 1.1_Skud475.2.fasta 1.1E+03 0.0193 0 1.0YLR040C_Skud1946.7.fasta YLR040C 1.1E+03 0.0241 0 5.2YLR141W_Skud1518.3.fasta YLR141W RRN5 1.1E+03 0.024 0.0076 6.3YCR054C_Skud2008.4.fasta YCR054C CTR86 1.1E+03 0.0235 0.0068 11.3YLR206W_Skud1413.4.fasta YLR206W ENT2 1.1E+03 0.023 0.0024 9.0YGL185C_Skud1778.4.fasta YGL185C 1.1E+03 0.0247 0.0034 6.5YBL043W_Skud1851.2.fasta YBL043W ECM13 1.1E+03 0.0236 0.0079 6.2YML066C_Skud1576.4.fasta YML066C SMA2 1.1E+03 0.0235 0.0039 7.2YNL315C_Skud1031.1.fasta YNL315C ATP11 1.1E+03 0.0234 0.0048 7.1YBL066C_Skud1889.9.fasta YBL066C SEF1 1.1E+03 0.023 0.0025 22.5YJR024C_Skud1630.4.fasta YJR024C MDE1 1.1E+03 0.0249 0.0019 5.5YOR185C_Skud1997.7.fasta YOR185C GSP2 1.1E+03 0.0232 0 5.1YMR130W_Skud1828.8.fasta YMR130W 1.1E+03 0.0234 0.0031 6.1YDR493W_Skud1671.6.fasta YDR493W AIM8 1.2E+03 0.0223 0.0038 2.1YMR096W_Skud1727.3.fasta YMR096W SNZ1 1.2E+03 0.0257 0 5.6YOR220W_Skud1033.2.fasta YOR220W RCN2 1.2E+03 0.0265 0.0078 7.0YLR295C_Skud2059.7.fasta YLR295C ATP14 1.2E+03 0.0221 0.0036 2.1YKL204W_Skud1772.2.fasta YKL204W EAP1 1.2E+03 0.025 0 2.3YOR158W_Skud1740.4.fasta YOR158W PET123 1.2E+03 0.0234 0.0014 5.1YOR254C_Skud1774.6.fasta YOR254C SEC63 1.2E+03 0.0227 0.0007 13.0YKR038C_Skud1606.7.fasta YKR038C KAE1 1.2E+03 0.0236 0.0025 8.3YDR019C_Skud2061.15.fasta YDR019C GCV1 1.2E+03 0.023 0.0036 8.1YNL292W_Skud1783.5.fasta YNL292W PUS4 1.2E+03 0.0229 0.0036 8.0YDR051C_Skud1362.4.fasta YDR051C DET1 1.2E+03 0.0237 0.0014 6.3YML108W_Skud1963.8.fasta YML108W 1.2E+03 0.0232 0 1.3YBR271W_Skud2064.3.fasta YBR271W 1.2E+03 0.0229 0.0025 10.1YGR127W_Skud1864.2.fasta YGR127W 1.2E+03 0.0243 0.0056 5.4YFR047C_Skud1972.8.fasta YFR047C BNA6 1.2E+03 0.0242 0.0015 5.3YJR116W_Skud1903.11.fasta YJR116W TDA4 1.2E+03 0.0224 0 2.1YKL126W_Skud1719.5.fasta YKL126W YPK1 1.2E+03 0.0248 0.0006 10.9YOR181W_Skud1997.10.fasta YOR181W LAS17 1.2E+03 0.024 0.0071 13.8YKL179C_Skud1782.3.fasta YKL179C COY1 1.2E+03 0.0239 0.0036 14.8YJL163C_Skud1754.6.fasta YJL163C 1.2E+03 0.0246 0.0017 12.0YOR031W_Skud936.2.fasta YOR031W CRS5 1.2E+03 0.0196 0.0136 1.1YPR071W_Skud1652.5.fasta YPR071W 1.2E+03 0.0225 0.0249 3.1YMR252C_Skud674.2.fasta YMR252C 1.2E+03 0.0221 0.0032 2.1YGR133W_Skud1500.4.fasta YGR133W PEX4 1.2E+03 0.0234 0.0028 3.2YHR085W_Skud1367.2.fasta YHR085W IPI1 1.2E+03 0.0229 0.0028 6.1YGR250C_Skud1999.8.fasta YGR250C 1.2E+03 0.0236 0.0037 16.8YDL133W_Skud1961.8.fasta YDL133W 1.2E+03 0.0229 0.001 8.1YPL097W_Skud2058.4.fasta YPL097W MSY1 1.2E+03 0.0233 0.0036 8.3YIR015W_Skud1568.5.fasta YIR015W RPR2 1.2E+03 0.0211 0.0098 2.0YDL043C_Skud1681.5.fasta YDL043C PRP11 1.2E+03 0.0235 0.0035 5.2YMR028W_Skud1450.4.fasta YMR028W TAP42 1.2E+03 0.0249 0.0043 4.5YLR360W_Skud1678.5.fasta YLR360W VPS38 1.2E+03 0.0231 0.0043 8.2YNL168C_Skud1953.3.fasta YNL168C FMP41 1.2E+03 0.0245 0.005 4.4YEL005C_Skud1494.3.fasta YEL005C VAB2 1.2E+03 0.0235 0.0082 5.2_Skud2016.3.fasta 1.2E+03 0.0001 0.0132 0.0YDR014W_Skud2061.10.fasta YDR014W RAD61 1.2E+03 0.0247 0.0053 11.0YDL061C_Skud1991.4.fasta YDL061C RPS29B 1.2E+03 0.0194 0 1.1YKL222C_Skud1775.2.fasta YKL222C 1.2E+03 0.0235 0.0165 13.6

YCL024W_Skud2072.21.fasta YCL024W KCC4 1.2E+03 0.0225 0.0028 21.2YBR170C_Skud1973.9.fasta YBR170C NPL4 1.2E+03 0.0239 0.0023 7.4YGR091W_Skud1356.2.fasta YGR091W PRP31 1.2E+03 0.0233 0.0056 9.3YNL100W_Skud1906.3.fasta YNL100W AIM37 1.2E+03 0.023 0.0097 4.2YDR152W_Skud1298.2.fasta YDR152W GIR2 1.2E+03 0.0225 0.0018 5.1YDL193W_Skud1732.3.fasta YDL193W NUS1 1.2E+03 0.0229 0 7.2YJR125C_Skud1903.2.fasta YJR125C ENT3 1.2E+03 0.0248 0.0031 6.7YNL177C_Skud1435.4.fasta YNL177C MRPL22 1.2E+03 0.0255 0.0032 6.9_Skud1560.4.fasta 1.2E+03 0.0199 0 1.1YLR204W_Skud1413.2.fasta YLR204W QRI5 1.2E+03 0.0196 0.0073 1.1YPL104W_Skud1429.2.fasta YPL104W MSD1 1.2E+03 0.0227 0.0044 13.2YNR035C_Skud1741.6.fasta YNR035C ARC35 1.2E+03 0.0232 0.004 6.3YLR211C_Skud1821.4.fasta YLR211C 1.2E+03 0.0214 0.0031 2.1YNL152W_Skud1924.3.fasta YNL152W INN1 1.2E+03 0.0233 0.0035 8.4YJL181W_Skud1825.6.fasta YJL181W 1.2E+03 0.0232 0.0132 12.5YDL069C_Skud1991.10.fasta YDL069C CBS1 1.2E+03 0.0261 0.0092 5.9YOR168W_Skud2050.10.fasta YOR168W GLN4 1.2E+03 0.0228 0.0029 15.4YIL088C_Skud1880.3.fasta YIL088C AVT7 1.2E+03 0.0227 0.005 9.2YGL019W_Skud1875.4.fasta YGL019W CKB1 1.3E+03 0.0245 0.0015 4.5YLR109W_Skud2004.4.fasta YLR109W AHP1 1.3E+03 0.0226 0 4.1YBL103C_Skud1948.3.fasta YBL103C RTG3 1.3E+03 0.0241 0.0009 8.7YHR032W_Skud1508.1.fasta YHR032W 1.3E+03 0.023 0.0015 10.3YGR262C_Skud1748.4.fasta YGR262C BUD32 1.3E+03 0.0234 0.0031 3.3YDL079C_Skud2062.13.fasta YDL079C MRK1 1.3E+03 0.023 0.0027 8.3YML019W_Skud2017.9.fasta YML019W OST6 1.3E+03 0.0241 0.0052 5.5YHR197W_Skud1689.2.fasta YHR197W RIX1 1.3E+03 0.0257 0.0018 5.8YNR052C_Skud1826.3.fasta YNR052C POP2 1.3E+03 0.0236 0.0011 8.5YHR148W_Skud1820.2.fasta YHR148W IMP3 1.3E+03 0.0222 0.0025 3.1YJL033W_Skud1454.2.fasta YJL033W HCA4 1.3E+03 0.0227 0 13.3YGR279C_Skud683.1.fasta YGR279C SCW4 1.3E+03 0.0251 0.0023 6.8_Skud2040.9.fasta 1.3E+03 0 0 0.0YDR367W_Skud1699.4.fasta YDR367W KEI1 1.3E+03 0.0268 0.0048 4.9_Skud1599.2.fasta 1.3E+03 0 0 0.0YPR005C_Skud1441.3.fasta YPR005C HAL1 1.3E+03 0.0221 0.0067 6.0_Skud1227.2.fasta 1.3E+03 0.0252 0.0014 6.9YOR100C_Skud2018.11.fasta YOR100C CRC1 1.3E+03 0.0226 0 8.2YPL111W_Skud999.1.fasta YPL111W CAR1 1.3E+03 0.0232 0.0014 6.3YEL046C_Skud1931.5.fasta YEL046C GLY1 1.3E+03 0.023 0 6.3YDR412W_Skud1527.4.fasta YDR412W RRP17 1.3E+03 0.0216 0 2.1YOR046C_Skud2015.12.fasta YOR046C DBP5 1.3E+03 0.0223 0.0028 11.1YGR120C_Skud1724.5.fasta YGR120C COG2 1.3E+03 0.0262 0.0055 6.0YKL050C_Skud2056.9.fasta YKL050C 1.3E+03 0.0224 0.009 18.3YML088W_Skud1488.3.fasta YML088W UFO1 1.3E+03 0.0228 0.0091 12.4YNL034W_Skud1789.4.fasta YNL034W 1.3E+03 0.023 0.0133 13.5YGL125W_Skud1717.2.fasta YGL125W MET13 1.3E+03 0.0243 0.0023 9.9YLR154W-A_Skud2074.1.fasta YLR154W-A 1.3E+03 0 0 0.0YMR138W_Skud1802.2.fasta YMR138W CIN4 1.3E+03 0.0217 0.0118 3.1YJR019C_Skud1630.7.fasta YJR019C TES1 1.3E+03 0.0223 0 4.1YDL085C-A_Skud2062.6.fasta YDL085C-A 1.3E+03 0.0173 0 1.0YDL110C_Skud1733.6.fasta YDL110C TMA17 1.3E+03 0.0217 0.0029 2.2YOR322C_Skud1824.2.fasta YOR322C LDB19 1.3E+03 0.0233 0.005 14.8YJR122W_Skud1903.5.fasta YJR122W IBA57 1.3E+03 0.0242 0.0071 11.0YGL173C_Skud1986.6.fasta YGL173C KEM1 1.3E+03 0.0227 0.0006 28.0

YHR179W_Skud2046.8.fasta YHR179W OYE2 1.3E+03 0.0234 0.0012 8.5YER164W_Skud1702.3.fasta YER164W CHD1 1.3E+03 0.0224 0.0013 27.6YOR243C_Skud1958.4.fasta YOR243C PUS7 1.3E+03 0.0225 0 5.2YDR419W_Skud1813.1.fasta YDR419W RAD30 1.3E+03 0.0221 0.0065 12.0YPR100W_Skud1693.2.fasta YPR100W MRPL51 1.3E+03 0.0201 0 2.0YPR094W_Skud1982.12.fasta YPR094W RDS3 1.3E+03 0.0201 0 2.0YGL248W_Skud1499.4.fasta YGL248W PDE1 1.3E+03 0.0222 0.0026 7.1YLR372W_Skud2027.7.fasta YLR372W SUR4 1.3E+03 0.0229 0.004 6.3YMR251W-A_Skud674.3.fasta YMR251W-A HOR7 1.3E+03 0.0325 0 1.9YPR066W_Skud1509.2.fasta YPR066W UBA3 1.3E+03 0.0225 0.0034 6.2_Skud1675.4.fasta 1.3E+03 0.0002 0.0221 0.0_Skud1960.8.fasta 1.3E+03 0 0 0.0YLR420W_Skud1928.10.fasta YLR420W URA4 1.3E+03 0.0229 0 7.3YBR254C_Skud2064.20.fasta YBR254C TRS20 1.3E+03 0.0209 0 2.1YCL027C-A_Skud2072.19.fasta YCL027C-A 1.3E+03 0.0218 0 4.1YLR078C_Skud989.8.fasta YLR078C BOS1 1.3E+03 0.02 0.0035 2.0YKL104C_Skud2010.5.fasta YKL104C GFA1 1.3E+03 0.0232 0.0006 11.6YGR055W_Skud2031.6.fasta YGR055W MUP1 1.3E+03 0.0229 0 11.5YLR407W_Skud2066.21.fasta YLR407W 1.3E+03 0.0224 0.0023 5.2YLR099C_Skud1763.4.fasta YLR099C ICT1 1.3E+03 0.0225 0.0071 7.2YPR107C_Skud1473.3.fasta YPR107C YTH1 1.3E+03 0.0233 0 2.4YOR076C_Skud1829.8.fasta YOR076C SKI7 1.3E+03 0.0235 0.0086 15.0YBL051C_Skud1725.4.fasta YBL051C PIN4 1.3E+03 0.0228 0.0028 12.5YOR286W_Skud1737.5.fasta YOR286W AIM42 1.3E+03 0.0214 0 2.2YOR180C_Skud1997.11.fasta YOR180C DCI1 1.3E+03 0.0219 0.0079 6.0YOR356W_Skud1930.3.fasta YOR356W 1.3E+03 0.0231 0.0036 11.6YNL131W_Skud1749.5.fasta YNL131W TOM22 1.3E+03 0.0211 0.0034 3.0YDR264C_Skud2012.8.fasta YDR264C AKR1 1.3E+03 0.0229 0.0037 14.6YBR194W_Skud1989.4.fasta YBR194W AIM4 1.3E+03 0.0173 0.0099 1.0YJR135C_Skud1942.4.fasta YJR135C MCM22 1.3E+03 0.0231 0.0034 3.3YGL213C_Skud1632.3.fasta YGL213C SKI8 1.3E+03 0.0221 0.0038 8.1YGL197W_Skud1912.4.fasta YGL197W MDS3 1.3E+03 0.0223 0.0045 17.3YEL060C_Skud1923.6.fasta YEL060C PRB1 1.3E+03 0.0232 0.0016 12.7YOL090W_Skud1742.2.fasta YOL090W MSH2 1.3E+03 0.022 0.0025 18.1YJL001W_Skud1686.5.fasta YJL001W PRE3 1.3E+03 0.0216 0 3.1YBR168W_Skud1973.11.fasta YBR168W PEX32 1.3E+03 0.022 0.0069 7.1YBR207W_Skud1766.2.fasta YBR207W FTH1 1.3E+03 0.023 0.004 8.4YPL271W_Skud2029.6.fasta YPL271W ATP15 1.3E+03 0.0181 0 1.1YIR003W_Skud1595.4.fasta YIR003W AIM21 1.3E+03 0.0227 0.0056 13.5YJR006W_Skud1955.11.fasta YJR006W POL31 1.3E+03 0.0229 0.0027 9.5YCR015C_Skud1836.4.fasta YCR015C 1.3E+03 0.0217 0.0013 4.1YNL306W_Skud1519.3.fasta YNL306W MRPS18 1.3E+03 0.0214 0.0043 4.0YDR287W_Skud1767.5.fasta YDR287W INM2 1.3E+03 0.0224 0 6.2YCR024C_Skud2048.9.fasta YCR024C SLM5 1.3E+03 0.0226 0.0047 9.3YOR093C_Skud1647.1.fasta YOR093C CMR2 1.3E+03 0.0221 0.0036 4.2YGR037C_Skud1926.6.fasta YGR037C ACB1 1.3E+03 0.029 0 3.0YDR439W_Skud1425.2.fasta YDR439W LRS4 1.3E+03 0.0217 0.0027 6.0YMR039C_Skud1486.4.fasta YMR039C SUB1 1.3E+03 0.0232 0.0013 4.4YNL207W_Skud1629.1.fasta YNL207W RIO2 1.3E+03 0.0228 0.0033 8.4YOL024W_Skud2060.10.fasta YOL024W 1.3E+03 0.0224 0.0031 4.2YMR040W_Skud1486.3.fasta YMR040W YET2 1.4E+03 0.0204 0.0057 2.1YDR033W_Skud2038.6.fasta YDR033W MRH1 1.4E+03 0.0233 0 5.4YDR237W_Skud2069.10.fasta YDR237W MRPL7 1.4E+03 0.0221 0.0047 5.2

YML109W_Skud1963.7.fasta YML109W ZDS2 1.4E+03 0.0222 0.0063 19.4YER132C_Skud1868.1.fasta YER132C PMD1 1.4E+03 0.0218 0.0031 30.2YER030W_Skud1757.4.fasta YER030W CHZ1 1.4E+03 0.0204 0.0028 2.1YKL004W_Skud1788.6.fasta YKL004W AUR1 1.4E+03 0.0227 0 7.4YKR055W_Skud1873.1.fasta YKR055W RHO4 1.4E+03 0.0215 0.0187 5.0YEL019C_Skud555.1.fasta YEL019C MMS21 1.4E+03 0.0222 0.0016 4.2YDR400W_Skud1573.2.fasta YDR400W URH1 1.4E+03 0.0232 0.0038 5.4YDR343C_Skud1649.2.fasta YDR343C HXT6 1.4E+03 0.0225 0.0015 6.3YBR025C_Skud2061.3.fasta YBR025C OLA1 1.4E+03 0.0224 0 7.3YBR024W_Skud2061.2.fasta YBR024W SCO2 1.4E+03 0.0215 0.003 5.0YOL064C_Skud1534.3.fasta YOL064C MET22 1.4E+03 0.0217 0.0045 8.0YLR341W_Skud1721.2.fasta YLR341W SPO77 1.4E+03 0.0221 0.0095 10.2YOL041C_Skud1723.6.fasta YOL041C NOP12 1.4E+03 0.0223 0.0038 7.2YBR143C_Skud2051.15.fasta YBR143C SUP45 1.4E+03 0.023 0.001 7.5YDL123W_Skud1786.2.fasta YDL123W SNA4 1.4E+03 0.0206 0 3.0YGR232W_Skud1935.9.fasta YGR232W NAS6 1.4E+03 0.0218 0.0021 4.2YBR137W_Skud1178.2.fasta YBR137W 1.4E+03 0.0205 0.0056 3.0YCL059C_Skud2065.14.fasta YCL059C KRR1 1.4E+03 0.0217 0 5.1YIL116W_Skud1925.3.fasta YIL116W HIS5 1.4E+03 0.0244 0.0025 7.9YPL225W_Skud1934.5.fasta YPL225W 1.4E+03 0.0205 0 3.0YLR293C_Skud2059.8.fasta YLR293C GSP1 1.4E+03 0.0218 0 5.1YDR483W_Skud1730.5.fasta YDR483W KRE2 1.4E+03 0.0229 0.0061 7.5YIL003W_Skud1620.3.fasta YIL003W CFD1 1.4E+03 0.0228 0.0048 4.4YHR209W_Skud1975.8.fasta YHR209W CRG1 1.4E+03 0.0215 0.0035 6.0YBR112C_Skud1877.4.fasta YBR112C CYC8 1.4E+03 0.0223 0.0016 19.6YDL218W_Skud1815.6.fasta YDL218W 1.4E+03 0.0222 0.0057 5.2YDL018C_Skud1867.5.fasta YDL018C ERP3 1.4E+03 0.0215 0.007 5.1_Skud1876.2.fasta 1.4E+03 0.0178 0.0129 1.1YNR008W_Skud1932.3.fasta YNR008W LRO1 1.4E+03 0.0227 0.0021 12.6YMR091C_Skud1803.2.fasta YMR091C NPL6 1.4E+03 0.022 0.0021 7.2YNL078W_Skud1628.3.fasta YNL078W NIS1 1.4E+03 0.0219 0.006 7.1YOR271C_Skud1463.2.fasta YOR271C FSF1 1.4E+03 0.0215 0.003 6.0YPL202C_Skud1659.3.fasta YPL202C AFT2 1.4E+03 0.0226 0.007 8.4YOR062C_Skud892.1.fasta YOR062C 1.4E+03 0.0215 0.0033 4.1YGL060W_Skud1952.2.fasta YGL060W YBP2 1.4E+03 0.0225 0.0087 13.5YJL193W_Skud1987.4.fasta YJL193W 1.4E+03 0.0222 0.0049 8.3YLR164W_Skud2071.3.fasta YLR164W 1.4E+03 0.0213 0.0028 3.2YOR130C_Skud1941.8.fasta YOR130C ORT1 1.4E+03 0.0215 0 5.1YLR361C_Skud1678.4.fasta YLR361C DCR2 1.4E+03 0.0223 0.001 9.3YOL019W_Skud2060.15.fasta YOL019W 1.4E+03 0.0229 0.0026 10.6YNL286W_Skud1837.3.fasta YNL286W CUS2 1.4E+03 0.0218 0.0097 5.2YGR084C_Skud1797.8.fasta YGR084C MRP13 1.4E+03 0.0216 0.0044 5.1YKL047W_Skud2056.6.fasta YKL047W ANR2 1.4E+03 0.023 0.0104 8.6YBR130C_Skud1937.5.fasta YBR130C SHE3 1.4E+03 0.0249 0.0009 5.9YLR440C_Skud1816.6.fasta YLR440C SEC39 1.4E+03 0.0216 0.0049 14.0YIL006W_Skud1909.7.fasta YIL006W YIA6 1.4E+03 0.0226 0.0012 7.4YPR116W_Skud1701.2.fasta YPR116W 1.4E+03 0.0215 0.0017 5.1YFL024C_Skud1442.3.fasta YFL024C EPL1 1.4E+03 0.0219 0.0011 16.2YPL216W_Skud1936.2.fasta YPL216W 1.4E+03 0.022 0.0123 19.4YGL230C_Skud1511.3.fasta YGL230C 1.4E+03 0.0205 0.0056 2.2YMR210W_Skud1558.2.fasta YMR210W 1.4E+03 0.0219 0.0021 8.2_Skud1586.3.fasta 1.4E+03 0.0209 0 3.1YOR001W_Skud1890.5.fasta YOR001W RRP6 1.4E+03 0.0221 0.0031 12.3

YHR143W_Skud2014.4.fasta YHR143W DSE2 1.4E+03 0.0216 0.0104 7.1_Skud2014.2.fasta 1.4E+03 0.0216 0.0104 7.1YDR101C_Skud1801.2.fasta YDR101C ARX1 1.4E+03 0.0217 0.0008 10.1YIL132C_Skud1475.4.fasta YIL132C CSM2 1.4E+03 0.0216 0.0046 4.2YLR201C_Skud1827.10.fasta YLR201C COQ9 1.4E+03 0.0216 0.0019 5.2YIR028W_Skud1859.6.fasta YIR028W DAL4 1.4E+03 0.0224 0 11.5YLR369W_Skud2027.4.fasta YLR369W SSQ1 1.4E+03 0.0221 0.0049 9.3YLR237W_Skud675.1.fasta YLR237W THI7 1.4E+03 0.0238 0.0028 8.9YDR174W_Skud1498.3.fasta YDR174W HMO1 1.4E+03 0.0218 0 4.2YLR257W_Skud1971.2.fasta YLR257W 1.4E+03 0.024 0 7.9YKL101W_Skud2010.3.fasta YKL101W HSL1 1.4E+03 0.0222 0.0031 27.9YGR246C_Skud1999.12.fasta YGR246C BRF1 1.4E+03 0.0216 0.0008 11.1YML009C_Skud796.2.fasta YML009C MRPL39 1.4E+03 0.0288 0 1.8YLR377C_Skud2027.12.fasta YLR377C FBP1 1.4E+03 0.0223 0.0013 6.4YML119W_Skud1679.2.fasta YML119W 1.4E+03 0.0223 0.0038 6.4YLR133W_Skud1776.6.fasta YLR133W CKI1 1.4E+03 0.0217 0.0017 11.1YMR055C_Skud1978.2.fasta YMR055C BUB2 1.4E+03 0.0216 0 6.2YNL149C_Skud1924.5.fasta YNL149C PGA2 1.4E+03 0.0164 0 1.0YHR126C_Skud1988.7.fasta YHR126C ANS1 1.4E+03 0.0202 0.0053 2.2YHL031C_Skud1834.5.fasta YHL031C GOS1 1.4E+03 0.0197 0 2.1YER010C_Skud1818.3.fasta YER010C 1.4E+03 0.0209 0.0102 4.1YOL129W_Skud2006.7.fasta YOL129W VPS68 1.4E+03 0.0208 0.003 4.1YGR288W_Skud1888.3.fasta YGR288W MAL13 1.4E+03 0.0224 0.0029 8.4YBR273C_Skud2064.1.fasta YBR273C UBX7 1.4E+03 0.0213 0.0044 8.0YDR307W_Skud1967.5.fasta YDR307W 1.4E+03 0.0222 0.0022 15.5YDR519W_Skud1594.2.fasta YDR519W FPR2 1.4E+03 0.0202 0 2.2YIL031W_Skud1694.2.fasta YIL031W ULP2 1.4E+03 0.0225 0.0049 18.9YMR272C_Skud2070.11.fasta YMR272C SCS7 1.4E+03 0.0211 0.0088 6.0YPR013C_Skud1714.3.fasta YPR013C CMR3 1.4E+03 0.0228 0.007 5.5YGL243W_Skud1407.3.fasta YGL243W TAD1 1.4E+03 0.0216 0.0036 7.2YPR009W_Skud1664.2.fasta YPR009W SUT2 1.4E+03 0.0212 0.0073 5.1YJL167W_Skud1754.2.fasta YJL167W ERG20 1.5E+03 0.0222 0.0026 6.4YCL034W_Skud2072.11.fasta YCL034W LSB5 1.5E+03 0.0207 0.0012 4.1YMR236W_Skud1773.3.fasta YMR236W TAF9 1.5E+03 0.0194 0 2.1YOR242C_Skud1958.3.fasta YOR242C SSP2 1.5E+03 0.0219 0.0036 6.3YMR273C_Skud2070.10.fasta YMR273C ZDS1 1.5E+03 0.022 0.0094 18.5YGR024C_Skud1043.1.fasta YGR024C THG1 1.5E+03 0.0001 0.0123 0.0YJL145W_Skud2041.12.fasta YJL145W SFH5 1.5E+03 0.0209 0.0016 5.1YKR016W_Skud2000.7.fasta YKR016W AIM28 1.5E+03 0.0233 0.0052 9.9YPR031W_Skud1841.1.fasta YPR031W NTO1 1.5E+03 0.0217 0.0032 14.2YBR054W_Skud1787.3.fasta YBR054W YRO2 1.5E+03 0.0223 0 6.4YNL141W_Skud1855.6.fasta YNL141W AAH1 1.5E+03 0.0221 0.0013 5.4YDR295C_Skud2003.6.fasta YDR295C HDA2 1.5E+03 0.0215 0.0056 12.1YOR165W_Skud2050.13.fasta YOR165W SEY1 1.5E+03 0.0228 0.0023 12.9YIL063C_Skud1784.5.fasta YIL063C YRB2 1.5E+03 0.0211 0.0102 6.1YIL093C_Skud1880.8.fasta YIL093C RSM25 1.5E+03 0.0197 0.004 2.1YJR097W_Skud1662.2.fasta YJR097W JJJ3 1.5E+03 0.0195 0.018 2.1YDL134C_Skud1961.7.fasta YDL134C PPH21 1.5E+03 0.0222 0 6.4YMR258C_Skud2070.25.fasta YMR258C 1.5E+03 0.0221 0.001 13.5YNL307C_Skud1519.2.fasta YNL307C MCK1 1.5E+03 0.0217 0.0012 6.3YJR105W_Skud1794.2.fasta YJR105W ADO1 1.5E+03 0.0223 0.0028 6.4YPL127C_Skud2019.3.fasta YPL127C HHO1 1.5E+03 0.0214 0.0017 4.2YMR211W_Skud1558.3.fasta YMR211W DML1 1.5E+03 0.0205 0 3.1

YPL050C_Skud1641.6.fasta YPL050C MNN9 1.5E+03 0.0197 0.0025 3.0YGR161C_Skud1871.5.fasta YGR161C RTS3 1.5E+03 0.0218 0.0055 5.3YGL070C_Skud2057.13.fasta YGL070C RPB9 1.5E+03 0.027 0 2.9YDR435C_Skud1598.4.fasta YDR435C PPM1 1.5E+03 0.021 0.0044 6.1YNL073W_Skud1657.1.fasta YNL073W MSK1 1.5E+03 0.0222 0.0046 9.5YBR250W_Skud2064.24.fasta YBR250W SPO23 1.5E+03 0.0218 0.0009 9.3YKR005C_Skud1938.2.fasta YKR005C 1.5E+03 0.0215 0.0139 9.2YML014W_Skud951.2.fasta YML014W TRM9 1.5E+03 0.0211 0 4.2YGL011C_Skud1261.2.fasta YGL011C SCL1 1.5E+03 0.0211 0.0044 4.2YDR003W_Skud1100.2.fasta YDR003W RCR2 1.5E+03 0.021 0 4.2YCR060W_Skud2008.7.fasta YCR060W TAH1 1.5E+03 0.0154 0.0148 1.0YML102W_Skud1950.9.fasta YML102W CAC2 1.5E+03 0.0213 0.0045 7.1YOR276W_Skud1682.3.fasta YOR276W CAF20 1.5E+03 0.0197 0.0031 2.2YNL092W_Skud1883.5.fasta YNL092W 1.5E+03 0.0223 0.0062 8.5YBR070C_Skud1650.4.fasta YBR070C ALG14 1.5E+03 0.021 0.004 4.2YLR437C_Skud922.2.fasta YLR437C DIF1 1.5E+03 0.0166 0 1.1YOR264W_Skud1703.6.fasta YOR264W DSE3 1.5E+03 0.0223 0.0158 7.5YKL028W_Skud1591.4.fasta YKL028W TFA1 1.5E+03 0.0218 0.0031 10.3YOR107W_Skud2018.6.fasta YOR107W RGS2 1.5E+03 0.0213 0.0129 7.2YOR274W_Skud1682.1.fasta YOR274W MOD5 1.5E+03 0.0217 0.0045 8.3YDR246W_Skud1915.3.fasta YDR246W TRS23 1.5E+03 0.02 0.0018 2.2YER063W_Skud1762.4.fasta YER063W THO1 1.5E+03 0.0201 0.0067 4.0YCR083W_Skud1764.3.fasta YCR083W TRX3 1.5E+03 0.0186 0.0125 2.0YDR350C_Skud2047.10.fasta YDR350C ATP22 1.5E+03 0.0215 0.0042 13.2YOR279C_Skud1682.5.fasta YOR279C RFM1 1.5E+03 0.0215 0.0029 5.3YLR016C_Skud2025.9.fasta YLR016C PML1 1.5E+03 0.0198 0.0066 3.1YFL017W-A_Skud1575.4.fasta YFL017W-A SMX2 1.5E+03 0.0168 0 1.1YBR242W_Skud1651.5.fasta YBR242W 1.5E+03 0.0214 0.002 4.3YBR104W_Skud904.2.fasta YBR104W YMC2 1.5E+03 0.0211 0.003 6.1YNL213C_Skud1138.1.fasta YNL213C 1.5E+03 0.0195 0.0063 3.0YOR177C_Skud2050.2.fasta YOR177C MPC54 1.5E+03 0.022 0.0086 7.4YDL115C_Skud1480.3.fasta YDL115C IWR1 1.5E+03 0.0201 0.0018 3.1YOR246C_Skud1958.7.fasta YOR246C 1.5E+03 0.0236 0.0033 8.0YDR075W_Skud1897.7.fasta YDR075W PPH3 1.5E+03 0.0213 0 5.2YGR027C_Skud1715.2.fasta YGR027C RPS25A 1.5E+03 0.0183 0 2.0YHR120W_Skud1988.2.fasta YHR120W MSH1 1.5E+03 0.0224 0.0045 18.0YBR173C_Skud1973.6.fasta YBR173C UMP1 1.5E+03 0.0198 0 3.1YKR065C_Skud2030.2.fasta YKR065C PAM17 1.5E+03 0.0201 0 3.1YKR072C_Skud2030.9.fasta YKR072C SIS2 1.5E+03 0.0226 0.0031 8.7YLR107W_Skud2004.2.fasta YLR107W REX3 1.5E+03 0.0209 0.0059 7.1YDR079W_Skud1897.3.fasta YDR079W PET100 1.5E+03 0.016 0.0038 1.1YBR063C_Skud1976.2.fasta YBR063C 1.5E+03 0.0217 0.0104 7.4YJL184W_Skud1825.8.fasta YJL184W GON7 1.5E+03 0.018 0.008 2.0YDL063C_Skud1991.5.fasta YDL063C 1.5E+03 0.0216 0.0074 10.3YBL078C_Skud1074.2.fasta YBL078C ATG8 1.5E+03 0.0182 0 2.0YMR078C_Skud1524.3.fasta YMR078C CTF18 1.5E+03 0.0209 0.0015 4.2YER136W_Skud1720.5.fasta YER136W GDI1 1.5E+03 0.0213 0.0022 9.2YJR007W_Skud1955.10.fasta YJR007W SUI2 1.5E+03 0.021 0 6.2YDR151C_Skud1298.3.fasta YDR151C CTH1 1.5E+03 0.0207 0.0061 6.1YOR047C_Skud2015.13.fasta YOR047C STD1 1.5E+03 0.0216 0.004 7.3YDR147W_Skud1848.3.fasta YDR147W EKI1 1.5E+03 0.0216 0.0069 9.4YOR319W_Skud1372.3.fasta YOR319W HSH49 1.5E+03 0.0198 0.0072 4.0YIL017C_Skud1960.7.fasta YIL017C VID28 1.5E+03 0.0212 0.0026 17.1

YIL123W_Skud2022.7.fasta YIL123W SIM1 1.6E+03 0.0221 0.0067 9.6YPL227C_Skud1934.7.fasta YPL227C ALG5 1.6E+03 0.0207 0.0058 6.1YHR142W_Skud2014.5.fasta YHR142W CHS7 1.6E+03 0.0215 0.0014 5.3YJL055W_Skud1314.2.fasta YJL055W 1.6E+03 0.0208 0.0057 4.2YBR161W_Skud1852.4.fasta YBR161W CSH1 1.6E+03 0.0212 0.0064 7.2YDR453C_Skud1543.2.fasta YDR453C TSA2 1.6E+03 0.0199 0 4.0YKL108W_Skud2010.9.fasta YKL108W SLD2 1.6E+03 0.0211 0.0057 6.2YDL161W_Skud1559.5.fasta YDL161W ENT1 1.6E+03 0.022 0.0008 5.5YBR285W_Skud1898.5.fasta YBR285W 1.6E+03 0.0178 0.0066 2.0YPR001W_Skud1777.7.fasta YPR001W CIT3 1.6E+03 0.0212 0.0048 8.2YPR108W_Skud1473.2.fasta YPR108W RPN7 1.6E+03 0.0149 0.0156 1.0YDR163W_Skud801.2.fasta YDR163W CWC15 1.6E+03 0.0199 0.0027 3.1YLR097C_Skud1763.2.fasta YLR097C HRT3 1.6E+03 0.021 0.0051 5.2YMR048W_Skud1978.7.fasta YMR048W CSM3 1.6E+03 0.0221 0.0053 4.5YBR072W_Skud1650.6.fasta YBR072W HSP26 1.6E+03 0.0199 0 2.3YJR086W_Skud1940.4.fasta YJR086W STE18 1.6E+03 0.0179 0.0049 2.0YDR299W_Skud2003.2.fasta YDR299W BFR2 1.6E+03 0.0211 0.006 9.2YDR245W_Skud1915.2.fasta YDR245W MNN10 1.6E+03 0.0214 0.0012 7.3YNL159C_Skud1189.2.fasta YNL159C ASI2 1.6E+03 0.0207 0.0099 5.2YOR378W_Skud2036.7.fasta YOR378W 1.6E+03 0.0227 0.0038 10.9YPR183W_Skud1438.2.fasta YPR183W DPM1 1.6E+03 0.0247 0.0016 3.9YDR398W_Skud1573.4.fasta YDR398W UTP5 1.6E+03 0.0178 0.0231 2.0YJR101W_Skud1794.6.fasta YJR101W RSM26 1.6E+03 0.0239 0.0057 6.0YMR013C_Skud2054.6.fasta YMR013C SEC59 1.6E+03 0.0215 0.004 10.4YBR160W_Skud1852.3.fasta YBR160W CDC28 1.6E+03 0.0203 0.0016 5.1YBR091C_Skud2011.4.fasta YBR091C TIM12 1.6E+03 0.0154 0.0039 1.1YPL157W_Skud2033.11.fasta YPL157W TGS1 1.6E+03 0.0209 0.0063 6.2YMR053C_Skud1978.4.fasta YMR053C STB2 1.6E+03 0.0218 0.0047 13.6YDR225W_Skud1379.3.fasta YDR225W HTA1 1.6E+03 0.0252 0 2.9YDR100W_Skud1801.3.fasta YDR100W TVP15 1.6E+03 0.0189 0.0039 3.0YBL093C_Skud1495.3.fasta YBL093C ROX3 1.6E+03 0.0146 0 1.0YGR044C_Skud1839.3.fasta YGR044C RME1 1.6E+03 0.0203 0.0048 5.1YOL113W_Skud1896.6.fasta YOL113W SKM1 1.6E+03 0.0213 0.0037 12.3YCR030C_Skud2035.3.fasta YCR030C SYP1 1.6E+03 0.0218 0.0041 14.7YHR159W_Skud1735.4.fasta YHR159W TDA11 1.6E+03 0.0214 0.0074 9.4YOR079C_Skud1829.5.fasta YOR079C ATX2 1.6E+03 0.0211 0 5.3YFR031C-A_Skud1504.7.fasta YFR031C-A RPL2A 1.6E+03 0 0 0.0YKR077W_Skud2030.14.fasta YKR077W MSA2 1.6E+03 0.0216 0.0128 7.5YPL172C_Skud1669.3.fasta YPL172C COX10 1.6E+03 0.0214 0.001 8.4YKL098W_Skud1520.2.fasta YKL098W MTC2 1.6E+03 0.0212 0.0051 7.3YOL047C_Skud1622.4.fasta YOL047C 1.6E+03 0.018 0.0055 2.1YGR255C_Skud1999.3.fasta YGR255C COQ6 1.6E+03 0.0219 0 7.6YKL017C_Skud1716.3.fasta YKL017C HCS1 1.6E+03 0.0209 0.005 12.1YPL129W_Skud2019.5.fasta YPL129W TAF14 1.6E+03 0 0 0.0YER107C_Skud1711.3.fasta YER107C GLE2 1.6E+03 0.0215 0 5.4YGR243W_Skud1008.2.fasta YGR243W FMP43 1.6E+03 0.0184 0 2.1YHL039W_Skud1947.5.fasta YHL039W 1.6E+03 0.0218 0.0081 12.7YAL037W_Skud1685.2.fasta YAL037W 1.6E+03 0.0234 0.012 5.9YFL046W_Skud638.2.fasta YFL046W FMP32 1.6E+03 0.0239 0 4.9YJR108W_Skud1281.3.fasta YJR108W ABM1 1.6E+03 0.0152 0.0048 1.1YGL028C_Skud2052.5.fasta YGL028C SCW11 1.6E+03 0.0201 0.0143 5.1YCR020C-A_Skud2048.5.fasta YCR020C-A MAK31 1.6E+03 0.0156 0.0053 1.1YOR278W_Skud1682.4.fasta YOR278W HEM4 1.6E+03 0.0199 0 4.1

YJL090C_Skud1640.2.fasta YJL090C DPB11 1.6E+03 0.0213 0.0057 14.4YDL106C_Skud1733.2.fasta YDL106C PHO2 1.6E+03 0.0208 0.0018 11.1YDR473C_Skud1959.5.fasta YDR473C PRP3 1.6E+03 0.0207 0.0066 7.2YOL027C_Skud2060.7.fasta YOL027C MDM38 1.6E+03 0.0208 0.0033 10.2YFL005W_Skud1648.3.fasta YFL005W SEC4 1.6E+03 0.0234 0.0166 1.7YGR252W_Skud1999.6.fasta YGR252W GCN5 1.6E+03 0.0212 0.0011 8.4YPR172W_Skud1422.4.fasta YPR172W 1.6E+03 0.0192 0.007 3.1_Skud1796.4.fasta 1.6E+03 0.0188 0.0036 3.1YFL023W_Skud1442.2.fasta YFL023W BUD27 1.6E+03 0.021 0.011 14.2YER070W_Skud1843.3.fasta YER070W RNR1 1.6E+03 0.0175 0 2.0YOR368W_Skud2013.4.fasta YOR368W RAD17 1.6E+03 0.0229 0.0024 8.0YNL125C_Skud1922.7.fasta YNL125C ESBP6 1.6E+03 0.0216 0 11.6YGL196W_Skud1912.5.fasta YGL196W DSD1 1.6E+03 0.0208 0.0073 6.3YGR136W_Skud1585.2.fasta YGR136W LSB1 1.6E+03 0.0203 0.0084 4.2YBR193C_Skud1989.3.fasta YBR193C MED8 1.6E+03 0.0193 0.007 4.0YOR142W_Skud1833.4.fasta YOR142W LSC1 1.6E+03 0.0204 0 6.2YDR111C_Skud1927.3.fasta YDR111C ALT2 1.6E+03 0.0213 0.0038 9.4YJR070C_Skud1916.5.fasta YJR070C LIA1 1.7E+03 0.0206 0.0015 6.2YEL009C_Skud1215.2.fasta YEL009C GCN4 1.7E+03 0.0203 0.0047 4.2YKR071C_Skud2030.8.fasta YKR071C DRE2 1.7E+03 0.0202 0.0014 6.1YMR132C_Skud1828.6.fasta YMR132C JLP2 1.7E+03 0.0178 0.0039 2.1YPR162C_Skud1949.2.fasta YPR162C ORC4 1.7E+03 0.0207 0.0045 9.2YKL193C_Skud1765.2.fasta YKL193C SDS22 1.7E+03 0.0223 0.0041 5.7YJL178C_Skud1825.3.fasta YJL178C ATG27 1.7E+03 0.0199 0.0074 5.1YDR410C_Skud1527.2.fasta YDR410C STE14 1.7E+03 0.0203 0.0102 6.1YOR238W_Skud1805.2.fasta YOR238W 1.7E+03 0.0203 0 6.1YER072W_Skud1843.5.fasta YER072W VTC1 1.7E+03 0.0171 0 2.0YPR068C_Skud1509.4.fasta YPR068C HOS1 1.7E+03 0.0212 0.0028 7.4YFR032C-A_Skud1504.5.fasta YFR032C-A RPL29 1.7E+03 0.0151 0 1.1YIL138C_Skud1832.6.fasta YIL138C TPM2 1.7E+03 0.0149 0.0024 1.1YEL033W_Skud1692.8.fasta YEL033W MTC7 1.7E+03 0.0147 0 1.1YOR035C_Skud2015.2.fasta YOR035C SHE4 1.7E+03 0.0208 0.0061 14.1_Skud1970.5.fasta 1.7E+03 0 0 0.0YLR408C_Skud2066.22.fasta YLR408C 1.7E+03 0.025 0.0049 2.9YDR384C_Skud1592.4.fasta YDR384C ATO3 1.7E+03 0.0234 0 4.9YGL212W_Skud1632.2.fasta YGL212W VAM7 1.7E+03 0.0198 0.0107 5.1YKR034W_Skud1606.3.fasta YKR034W DAL80 1.7E+03 0.0191 0.0034 4.0YPL118W_Skud1951.6.fasta YPL118W MRP51 1.7E+03 0.0199 0.0039 5.1YHR112C_Skud2024.7.fasta YHR112C 1.7E+03 0.0202 0.0012 6.1YER055C_Skud2039.10.fasta YER055C HIS1 1.7E+03 0.0208 0 4.4YNL090W_Skud1883.3.fasta YNL090W RHO2 1.7E+03 0.0188 0.0025 3.1YCL005W_Skud1939.5.fasta YCL005W LDB16 1.7E+03 0.0199 0 5.1YDR082W_Skud1929.3.fasta YDR082W STN1 1.7E+03 0.0216 0.0115 9.6YLR167W_Skud2071.6.fasta YLR167W RPS31 1.7E+03 0.0158 0 1.1YLR194C_Skud1827.4.fasta YLR194C 1.7E+03 0.0201 0.0022 5.2YLR011W_Skud2025.14.fasta YLR011W LOT6 1.7E+03 0.0192 0.0099 3.2YPL046C_Skud1641.2.fasta YPL046C ELC1 1.7E+03 0.0171 0 2.0YOR137C_Skud1633.2.fasta YOR137C SIA1 1.7E+03 0.0213 0.0037 10.5YML081W_Skud1623.3.fasta YML081W TDA9 1.7E+03 0.0213 0.0039 20.6YNL101W_Skud1906.2.fasta YNL101W AVT4 1.7E+03 0.0214 0.0013 12.6YDL186W_Skud2045.14.fasta YDL186W 1.7E+03 0.0206 0.0065 5.3YDL188C_Skud2045.15.fasta YDL188C PPH22 1.7E+03 0.0208 0.0013 5.4YPR058W_Skud1546.6.fasta YPR058W YMC1 1.7E+03 0.0198 0.0047 5.1

YIL009C-A_Skud1125.2.fasta YIL009C-A EST3 1.7E+03 0.015 0.01 1.1YMR089C_Skud1803.4.fasta YMR089C YTA12 1.7E+03 0.0212 0.0022 13.5YOR256C_Skud1774.4.fasta YOR256C TRE2 1.7E+03 0.0214 0.0053 11.6YOL025W_Skud2060.9.fasta YOL025W LAG2 1.7E+03 0.022 0.0124 14.0YOR339C_Skud2005.8.fasta YOR339C UBC11 1.7E+03 0.0241 0.0102 4.0YLR258W_Skud1971.3.fasta YLR258W GSY2 1.7E+03 0.0207 0 13.2YNL259C_Skud1199.2.fasta YNL259C ATX1 1.7E+03 0 0 0.0YGR008C_Skud1670.5.fasta YGR008C STF2 1.7E+03 0.0141 0 1.0_Skud2072.23.fasta 1.7E+03 0.0193 0 4.1YOR026W_Skud1983.5.fasta YOR026W BUB3 1.7E+03 0.02 0.0057 6.1YJL164C_Skud1754.5.fasta YJL164C TPK1 1.7E+03 0.0203 0.0026 7.2YPL134C_Skud2019.10.fasta YPL134C ODC1 1.7E+03 0.0198 0.0031 5.1YLR399C_Skud2066.14.fasta YLR399C BDF1 1.7E+03 0.0212 0.004 12.5YDL077C_Skud2062.15.fasta YDL077C VAM6 1.7E+03 0.0208 0.0031 18.2YMR274C_Skud2070.9.fasta YMR274C RCE1 1.7E+03 0.0201 0.0064 6.2YJL069C_Skud1625.7.fasta YJL069C UTP18 1.7E+03 0.0212 0.0045 9.5YKL096W_Skud1520.5.fasta YKL096W CWP1 1.7E+03 0.0199 0.002 3.3YBR284W_Skud1898.6.fasta YBR284W 1.7E+03 0.0209 0.0049 15.3YJR052W_Skud1533.2.fasta YJR052W RAD7 1.7E+03 0.0209 0.0018 11.3YKR079C_Skud2030.16.fasta YKR079C TRZ1 1.7E+03 0.0213 0.005 14.6YNL107W_Skud1428.2.fasta YNL107W YAF9 1.7E+03 0.0191 0.002 3.2YGL136C_Skud1469.1.fasta YGL136C MRM2 1.7E+03 0.0196 0.0014 5.1YCR020C_Skud2048.4.fasta YCR020C PET18 1.7E+03 0.0156 0 1.1YMR215W_Skud1400.3.fasta YMR215W GAS3 1.7E+03 0.0206 0.001 11.2YDR378C_Skud1409.4.fasta YDR378C LSM6 1.7E+03 0.0139 0 1.0YOR363C_Skud2013.7.fasta YOR363C PIP2 1.7E+03 0.0206 0.0015 19.0YDR021W_Skud1760.2.fasta YDR021W FAL1 1.7E+03 0.0202 0 6.2YLR142W_Skud1518.4.fasta YLR142W PUT1 1.7E+03 0.0202 0.0019 7.2YHL024W_Skud1842.3.fasta YHL024W RIM4 1.7E+03 0.0217 0.0026 11.8YOR057W_Skud1846.4.fasta YOR057W SGT1 1.7E+03 0.0205 0.0048 7.3YMR106C_Skud1332.5.fasta YMR106C YKU80 1.7E+03 0.0211 0.0035 9.5YDR361C_Skud1964.6.fasta YDR361C BCP1 1.7E+03 0.0202 0 3.4YBR085W_Skud2011.12.fasta YBR085W AAC3 1.7E+03 0.0204 0 4.4YIL024C_Skud1791.3.fasta YIL024C 1.7E+03 0.0183 0.0026 3.1YDR181C_Skud1600.2.fasta YDR181C SAS4 1.7E+03 0.0203 0.0045 6.3YPL213W_Skud1936.5.fasta YPL213W LEA1 1.7E+03 0.0232 0.0041 5.0YJR003C_Skud1491.2.fasta YJR003C 1.7E+03 0.0208 0.0055 9.4YDR130C_Skud1908.7.fasta YDR130C FIN1 1.7E+03 0.0196 0.0061 4.2YNL151C_Skud1924.4.fasta YNL151C RPC31 1.7E+03 0.0181 0 2.2YBR114W_Skud1877.2.fasta YBR114W RAD16 1.7E+03 0.0211 0.0028 12.5YML129C_Skud1995.7.fasta YML129C COX14 1.7E+03 0.0264 0 2.0YLR289W_Skud2059.12.fasta YLR289W GUF1 1.7E+03 0.0181 0.0047 3.0YJL151C_Skud1424.3.fasta YJL151C SNA3 1.7E+03 0.0143 0.0106 1.1YDR117C_Skud1927.7.fasta YDR117C TMA64 1.7E+03 0.0208 0.0047 8.4YLR354C_Skud1341.2.fasta YLR354C TAL1 1.7E+03 0.0204 0.0015 6.3YOL020W_Skud2060.14.fasta YOL020W TAT2 1.7E+03 0.0209 0 9.4YDR017C_Skud2061.13.fasta YDR017C KCS1 1.7E+03 0.0213 0.0056 17.7YLR426W_Skud1798.2.fasta YLR426W TDA5 1.7E+03 0.0185 0.0021 2.3YGL020C_Skud1875.3.fasta YGL020C GET1 1.7E+03 0.0188 0.0043 4.1YMR192W_Skud1752.5.fasta YMR192W GYL1 1.7E+03 0.0209 0.0079 11.4YOR164C_Skud2050.14.fasta YOR164C GET4 1.7E+03 0.02 0 4.3YML058W-A_Skud1726.2.fasta YML058W-A HUG1 1.7E+03 0 0 0.0YOR196C_Skud1770.5.fasta YOR196C LIP5 1.7E+03 0.0199 0.0069 7.1

YDL204W_Skud1850.6.fasta YDL204W RTN2 1.7E+03 0.0199 0.0138 7.1YPL161C_Skud2033.7.fasta YPL161C BEM4 1.8E+03 0.0202 0.0046 10.1YBL019W_Skud1707.3.fasta YBL019W APN2 1.8E+03 0.0207 0.007 8.4YCL002C_Skud1939.7.fasta YCL002C 1.8E+03 0.0178 0.0033 3.0YOL102C_Skud1755.4.fasta YOL102C TPT1 1.8E+03 0.0228 0.0023 4.9YMR014W_Skud2054.7.fasta YMR014W BUD22 1.8E+03 0.0202 0.0034 7.2YOR297C_Skud1320.2.fasta YOR297C TIM18 1.8E+03 0.0186 0.0023 4.0YGL106W_Skud742.1.fasta YGL106W MLC1 1.8E+03 0.0234 0 2.9YDL177C_Skud2045.6.fasta YDL177C 1.8E+03 0.0179 0.003 3.0YER149C_Skud1636.3.fasta YER149C PEA2 1.8E+03 0.0217 0.0024 8.8YBR149W_Skud2051.10.fasta YBR149W ARA1 1.8E+03 0.0198 0.0013 5.2YGL174W_Skud1986.7.fasta YGL174W BUD13 1.8E+03 0.019 0.0082 4.1YML131W_Skud1995.5.fasta YML131W 1.8E+03 0.0196 0.0013 6.1YER180C_Skud1901.3.fasta YER180C ISC10 1.8E+03 0.0188 0.0034 4.1YOR016C_Skud1656.5.fasta YOR016C ERP4 1.8E+03 0.0182 0.0086 3.1YKL216W_Skud1994.5.fasta YKL216W URA1 1.8E+03 0.0203 0.0022 6.3YNL123W_Skud1922.5.fasta YNL123W NMA111 1.8E+03 0.021 0.0023 16.6YMR107W_Skud1332.6.fasta YMR107W SPG4 1.8E+03 0.0169 0.0045 2.1YKR075C_Skud2030.12.fasta YKR075C 1.8E+03 0.0195 0.0072 4.2YKL052C_Skud2056.11.fasta YKL052C ASK1 1.8E+03 0.0192 0.0062 4.2YMR262W_Skud2070.21.fasta YMR262W 1.8E+03 0.0193 0.0075 5.1_Skud1575.2.fasta 1.8E+03 0 0 0.0YHR005C_Skud2067.17.fasta YHR005C GPA1 1.8E+03 0.0201 0.004 8.2YMR119W_Skud2044.4.fasta YMR119W ASI1 1.8E+03 0.0208 0.0052 10.5YGR054W_Skud2031.7.fasta YGR054W 1.8E+03 0.0208 0 10.5YNL045W_Skud1809.6.fasta YNL045W LAP2 1.8E+03 0.0211 0.0041 11.6YKL208W_Skud1772.6.fasta YKL208W CBT1 1.8E+03 0.0182 0.0016 3.1YNL199C_Skud1680.6.fasta YNL199C GCR2 1.8E+03 0.0205 0.0026 8.4YLR308W_Skud1779.4.fasta YLR308W CDA2 1.8E+03 0.0198 0.0032 5.3YER012W_Skud1818.7.fasta YER012W PRE1 1.8E+03 0.0174 0 2.2YJL085W_Skud1445.2.fasta YJL085W EXO70 1.8E+03 0.0254 0 2.0YOR385W_Skud2036.1.fasta YOR385W 1.8E+03 0.0191 0.0081 4.2YGL257C_Skud2049.7.fasta YGL257C MNT2 1.8E+03 0.0225 0.0109 6.0YNR020C_Skud1660.5.fasta YNR020C ATP23 1.8E+03 0.0183 0.0044 4.0YNL124W_Skud1922.6.fasta YNL124W NAF1 1.8E+03 0.0206 0.0055 7.4_Skud1955.8.fasta 1.8E+03 0.013 0 1.0YBR297W_Skud1849.2.fasta YBR297W MAL33 1.8E+03 0.0203 0 8.3YAL055W_Skud1874.5.fasta YAL055W PEX22 1.8E+03 0.0178 0.0097 2.2YGR249W_Skud1999.9.fasta YGR249W MGA1 1.8E+03 0.0207 0.0035 9.5YCR028C-A_Skud2035.2.fasta YCR028C-A RIM1 1.8E+03 0.0131 0 1.0YHR152W_Skud1820.6.fasta YHR152W SPO12 1.8E+03 0.0169 0.0026 2.1YOR176W_Skud2050.4.fasta YOR176W HEM15 1.8E+03 0.0196 0.0026 7.1YOR249C_Skud1958.9.fasta YOR249C APC5 1.8E+03 0.0205 0.0028 12.3YCL025C_Skud2072.20.fasta YCL025C AGP1 1.8E+03 0.0212 0.0029 10.7YOL069W_Skud1212.3.fasta YOL069W NUF2 1.8E+03 0.0194 0.001 6.1YCR027C_Skud2048.13.fasta YCR027C RHB1 1.8E+03 0.0183 0.0022 3.1YPL183W-A_Skud1462.2.fasta YPL183W-A RTC6 1.8E+03 0.0129 0.0103 1.0YGL169W_Skud1986.2.fasta YGL169W SUA5 1.8E+03 0.0196 0.0045 7.1YER145C_Skud1631.2.fasta YER145C FTR1 1.8E+03 0.0183 0.0013 3.2YDL219W_Skud1815.7.fasta YDL219W DTD1 1.8E+03 0.0162 0 2.0YGR175C_Skud2063.7.fasta YGR175C ERG1 1.8E+03 0.0192 0.0025 6.1YLR413W_Skud1928.4.fasta YLR413W 1.8E+03 0.0207 0.0095 12.5YGR010W_Skud1670.3.fasta YGR010W NMA2 1.8E+03 0.0201 0 5.4

YMR122W-A_Skud2044.7.fasta YMR122W-A 1.8E+03 0.013 0 1.0YDR096W_Skud1417.1.fasta YDR096W GIS1 1.8E+03 0.0203 0.0053 16.1YML065W_Skud1576.3.fasta YML065W ORC1 1.8E+03 0.0212 0.001 13.8YDR523C_Skud2001.2.fasta YDR523C SPS1 1.8E+03 0.0202 0.0009 7.4YLR099W-A_Skud1763.5.fasta YLR099W-A 1.8E+03 0.0254 0.0118 2.0YGR123C_Skud1864.6.fasta YGR123C PPT1 1.8E+03 0.0201 0.0027 8.3YDR076W_Skud1897.6.fasta YDR076W RAD55 1.8E+03 0.0198 0.0024 7.2YDR079C-A_Skud1897.2.fasta YDR079C-A TFB5 1.8E+03 0.0128 0 1.0YNL025C_Skud1892.2.fasta YNL025C SSN8 1.8E+03 0.0187 0 5.0YBR222C_Skud1147.1.fasta YBR222C PCS60 1.8E+03 0.0199 0.0047 8.2YGL163C_Skud2042.1.fasta YGL163C RAD54 1.8E+03 0.0203 0.0005 16.2YKL183W_Skud1483.2.fasta YKL183W LOT5 1.8E+03 0.0188 0.0029 4.2YOR110W_Skud2018.3.fasta YOR110W TFC7 1.8E+03 0.0204 0.0038 5.5YDR321W_Skud1363.2.fasta YDR321W ASP1 1.8E+03 0.0194 0 5.2YBL102W_Skud1948.4.fasta YBL102W SFT2 1.8E+03 0.018 0 3.1YPL024W_Skud1562.3.fasta YPL024W RMI1 1.8E+03 0.018 0.0015 3.1YOR213C_Skud1769.3.fasta YOR213C SAS5 1.8E+03 0.0193 0.015 4.3YLR314C_Skud1965.5.fasta YLR314C CDC3 1.8E+03 0.0215 0.002 11.0YPL132W_Skud2019.8.fasta YPL132W COX11 1.8E+03 0.0195 0.003 4.3YIL042C_Skud1799.6.fasta YIL042C PKP1 1.8E+03 0.022 0 7.0YPR199C_Skud1995.3.fasta YPR199C ARR1 1.8E+03 0.0186 0.0014 4.1YGL119W_Skud2026.11.fasta YGL119W ABC1 1.8E+03 0.0202 0.0055 8.4YDR056C_Skud1307.2.fasta YDR056C 1.8E+03 0.0225 0.0092 3.9YCL008C_Skud1939.3.fasta YCL008C STP22 1.8E+03 0.0198 0.0048 6.3YGR156W_Skud1268.1.fasta YGR156W PTI1 1.9E+03 0.0204 0.0056 7.5YNL044W_Skud1809.5.fasta YNL044W YIP3 1.9E+03 0.0236 0.0033 3.0YLR168C_Skud2071.7.fasta YLR168C UPS2 1.9E+03 0.0186 0.0019 3.3YGL134W_Skud869.2.fasta YGL134W PCL10 1.9E+03 0.0194 0.0065 7.1YJL063C_Skud1625.3.fasta YJL063C MRPL8 1.9E+03 0.022 0.0078 3.8YOR223W_Skud1729.3.fasta YOR223W 1.9E+03 0.0187 0 4.2YOR179C_Skud1997.12.fasta YOR179C SYC1 1.9E+03 0.0164 0 2.1YML022W_Skud2017.6.fasta YML022W APT1 1.9E+03 0.0181 0.0052 3.2YCL007C_Skud1939.4.fasta YCL007C 1.9E+03 0.0132 0.0075 1.1YMR002W_Skud2043.10.fasta YMR002W MIC17 1.9E+03 0.017 0.0034 2.2YGL170C_Skud1986.3.fasta YGL170C SPO74 1.9E+03 0.02 0.0089 4.5YGR159C_Skud1019.2.fasta YGR159C NSR1 1.9E+03 0.0209 0 5.7YLR395C_Skud2066.10.fasta YLR395C COX8 1.9E+03 0 0 0.0YKR058W_Skud1873.4.fasta YKR058W GLG1 1.9E+03 0.0209 0.0098 8.7YHL026C_Skud1842.1.fasta YHL026C 1.9E+03 0.019 0.0062 5.2YIL061C_Skud1784.3.fasta YIL061C SNP1 1.9E+03 0.0192 0.0032 5.2YNL104C_Skud1879.2.fasta YNL104C LEU4 1.9E+03 0.0203 0 11.4YHR110W_Skud2024.9.fasta YHR110W ERP5 1.9E+03 0.0175 0.0022 3.1YOR389W_Skud2029.1.fasta YOR389W 1.9E+03 0.0202 0.0024 11.3YBR088C_Skud2011.7.fasta YBR088C POL30 1.9E+03 0.022 0 6.0YLR035C_Skud1946.3.fasta YLR035C MLH2 1.9E+03 0.02 0.0073 11.2YDR324C_Skud1577.3.fasta YDR324C UTP4 1.9E+03 0.0203 0.0025 12.4YDR214W_Skud1135.1.fasta YDR214W AHA1 1.9E+03 0.0189 0.0062 4.2YOR375C_Skud2036.10.fasta YOR375C GDH1 1.9E+03 0.0202 0.0011 8.4YMR090W_Skud1803.3.fasta YMR090W 1.9E+03 0.0221 0.0023 4.9YLR153C_Skud1743.2.fasta YLR153C ACS2 1.9E+03 0.0203 0 13.3YDL175C_Skud2045.4.fasta YDL175C AIR2 1.9E+03 0.0189 0.0025 4.2YML025C_Skud2017.3.fasta YML025C YML6 1.9E+03 0.0173 0 3.0YPR122W_Skud1617.2.fasta YPR122W AXL1 1.9E+03 0.0204 0.0033 22.3

YDR371W_Skud1687.5.fasta YDR371W CTS2 1.9E+03 0.02 0.0048 9.3YIR009W_Skud1884.3.fasta YIR009W MSL1 1.9E+03 0.0248 0.0042 2.0YIL124W_Skud2022.6.fasta YIL124W AYR1 1.9E+03 0.0192 0.0033 5.2YOR381W_Skud2036.5.fasta YOR381W FRE3 1.9E+03 0.0134 0.0184 1.1YLR115W_Skud2004.10.fasta YLR115W CFT2 1.9E+03 0.0202 0.0053 13.3YLR018C_Skud2025.7.fasta YLR018C POM34 1.9E+03 0.0216 0.0017 5.9YLR292C_Skud2059.9.fasta YLR292C SEC72 1.9E+03 0.0172 0 3.0YNL007C_Skud1479.2.fasta YNL007C SIS1 1.9E+03 0.0194 0.0024 5.3YDR358W_Skud1964.4.fasta YDR358W GGA1 1.9E+03 0.0199 0.0023 7.4YDR261C_Skud2012.5.fasta YDR261C EXG2 1.9E+03 0.0204 0.0056 8.5YGR017W_Skud1408.3.fasta YGR017W 1.9E+03 0.0186 0 3.3YDL107W_Skud1733.3.fasta YDL107W MSS2 1.9E+03 0.0193 0.0073 4.3YDL241W_Skud1899.8.fasta YDL241W 1.9E+03 0.013 0.0303 1.1YAL053W_Skud1874.7.fasta YAL053W FLC2 1.9E+03 0.0198 0.0026 14.0YPL185W_Skud1230.4.fasta YPL185W 1.9E+03 0.0001 0.0068 0.0YLR392C_Skud2066.7.fasta YLR392C 1.9E+03 0.02 0.0044 8.4YER095W_Skud2009.10.fasta YER095W RAD51 1.9E+03 0.0198 0.0046 6.4YML112W_Skud1963.4.fasta YML112W CTK3 1.9E+03 0.0182 0.0017 5.0YNL010W_Skud1566.2.fasta YNL010W 1.9E+03 0.0192 0 2.5YPL162C_Skud2033.6.fasta YPL162C 1.9E+03 0.0183 0.0034 4.1YNL304W_Skud1872.2.fasta YNL304W YPT11 1.9E+03 0 0 0.0YGL117W_Skud2026.9.fasta YGL117W 1.9E+03 0.0182 0.0253 4.1YDR200C_Skud1918.6.fasta YDR200C VPS64 1.9E+03 0.02 0.003 9.4YGR225W_Skud1453.2.fasta YGR225W AMA1 1.9E+03 0.0136 0.0085 1.1YIL092W_Skud1880.7.fasta YIL092W 1.9E+03 0.0201 0.0136 10.4YOL022C_Skud2060.12.fasta YOL022C TSR4 1.9E+03 0.0187 0.0011 6.1YBR131W_Skud1937.6.fasta YBR131W CCZ1 1.9E+03 0 0 0.0_Skud2004.8.fasta 1.9E+03 0.0193 0.0013 7.2YGR121C_Skud1724.6.fasta YGR121C MEP1 1.9E+03 0.02 0.001 9.4YER173W_Skud1863.2.fasta YER173W RAD24 1.9E+03 0.0202 0.0077 10.5YNL275W_Skud1423.2.fasta YNL275W BOR1 1.9E+03 0.0203 0.0048 9.5YMR059W_Skud1449.2.fasta YMR059W SEN15 1.9E+03 0.0153 0.0042 2.0YKL011C_Skud1330.2.fasta YKL011C CCE1 1.9E+03 0.0188 0.0011 3.4YGR230W_Skud1935.11.fasta YGR230W BNS1 1.9E+03 0.0156 0.0103 2.0YFL059W_Skud1990.9.fasta YFL059W SNZ3 1.9E+03 0 0 0.0YBR076W_Skud1661.3.fasta YBR076W ECM8 1.9E+03 0.0191 0 7.1YNL051W_Skud1564.4.fasta YNL051W COG5 1.9E+03 0.0191 0.0092 6.2YPL181W_Skud1972.13.fasta YPL181W CTI6 1.9E+03 0.02 0.0037 8.5YMR154C_Skud1956.9.fasta YMR154C RIM13 1.9E+03 0.0198 0.0052 12.2YDR319C_Skud1476.3.fasta YDR319C YFT2 1.9E+03 0.0195 0.0036 4.5YEL030W_Skud1612.2.fasta YEL030W ECM10 1.9E+03 0.0195 0 11.1YCR079W_Skud1704.2.fasta YCR079W PTC6 1.9E+03 0.0209 0.0033 7.8YGL077C_Skud2057.8.fasta YGL077C HNM1 1.9E+03 0.0201 0.0009 10.5YGR231C_Skud1935.10.fasta YGR231C PHB2 1.9E+03 0.0171 0.0022 3.1YKL110C_Skud2020.12.fasta YKL110C KTI12 1.9E+03 0.0184 0.0016 5.1YIR025W_Skud1859.3.fasta YIR025W MND2 1.9E+03 0.019 0.0066 6.2YNR003C_Skud1932.7.fasta YNR003C RPC34 1.9E+03 0.0184 0 4.2YLR165C_Skud2071.4.fasta YLR165C PUS5 1.9E+03 0.0173 0.0035 3.1YCR067C_Skud1668.2.fasta YCR067C SED4 1.9E+03 0.0206 0.0147 18.7YHR206W_Skud1913.2.fasta YHR206W SKN7 1.9E+03 0.0199 0.0007 9.4YNL158W_Skud1189.3.fasta YNL158W PGA1 2.0E+03 0.0172 0.0122 3.1YCR076C_Skud1704.4.fasta YCR076C 2.0E+03 0.018 0.0041 4.1YJL043W_Skud1920.5.fasta YJL043W 2.0E+03 0.0215 0.0107 3.9

YHR210C_Skud1975.7.fasta YHR210C 2.0E+03 0.0181 0.0015 5.0YCL048W_Skud2065.3.fasta YCL048W SPS22 2.0E+03 0.0212 0.001 8.0YOL098C_Skud1507.2.fasta YOL098C 2.0E+03 0.0206 0.0017 15.7YBL049W_Skud1725.2.fasta YBL049W MOH1 2.0E+03 0.0122 0.0031 1.0YDL089W_Skud2062.2.fasta YDL089W NUR1 2.0E+03 0.0191 0.0084 7.2YBR196C_Skud1989.6.fasta YBR196C PGI1 2.0E+03 0.0203 0.0009 10.6YNL339C_Skud2068.2.fasta YNL339C YRF1-6 2.0E+03 0.0187 0.0068 6.1YOR374W_Skud2036.11.fasta YOR374W ALD4 2.0E+03 0.0197 0 8.4YLR456W_Skud1885.5.fasta YLR456W 2.0E+03 0.0162 0.0063 2.2YIL104C_Skud1790.2.fasta YIL104C SHQ1 2.0E+03 0.0201 0.005 6.6YKR067W_Skud2030.4.fasta YKR067W GPT2 2.0E+03 0.0197 0.0031 11.3YAL032C_Skud1176.1.fasta YAL032C PRP45 2.0E+03 0.0186 0.0025 6.1YGR131W_Skud1500.2.fasta YGR131W 2.0E+03 0.0158 0 2.1YGR074W_Skud1944.3.fasta YGR074W SMD1 2.0E+03 0.0128 0 1.1YHR014W_Skud2067.7.fasta YHR014W SPO13 2.0E+03 0.0178 0.0016 4.1YGL250W_Skud1399.1.fasta YGL250W RMR1 2.0E+03 0.0174 0.0081 4.0YLR135W_Skud1776.3.fasta YLR135W SLX4 2.0E+03 0.0201 0.0079 11.5YLR300W_Skud2059.3.fasta YLR300W EXG1 2.0E+03 0.0195 0.0012 9.3YDR497C_Skud1671.2.fasta YDR497C ITR1 2.0E+03 0.0209 0.0009 12.0YIL097W_Skud1344.2.fasta YIL097W FYV10 2.0E+03 0.0203 0.0051 9.7YDR011W_Skud1100.7.fasta YDR011W SNQ2 2.0E+03 0.0201 0.0025 25.2YDR306C_Skud1967.6.fasta YDR306C 2.0E+03 0.02 0.0033 8.5YGR068C_Skud1944.7.fasta YGR068C ART5 2.0E+03 0.0193 0.0008 10.1YGL237C_Skud1238.2.fasta YGL237C HAP2 2.0E+03 0.0173 0.0112 3.2YMR108W_Skud1332.7.fasta YMR108W ILV2 2.0E+03 0.0206 0.0014 11.8_Skud1939.9.fasta 2.0E+03 0.0174 0.0056 3.2YCR059C_Skud2008.6.fasta YCR059C YIH1 2.0E+03 0.0178 0.003 4.1YDL142C_Skud1005.2.fasta YDL142C CRD1 2.0E+03 0.0178 0.0095 5.0YPL009C_Skud1619.4.fasta YPL009C 2.0E+03 0.0198 0.0042 15.2YGL229C_Skud1511.4.fasta YGL229C SAP4 2.0E+03 0.0193 0.0063 10.1YJR133W_Skud1942.2.fasta YJR133W XPT1 2.0E+03 0.016 0.002 2.1YKL016C_Skud1716.2.fasta YKL016C ATP7 2.0E+03 0.0152 0.0027 2.0YBR003W_Skud1395.3.fasta YBR003W COQ1 2.0E+03 0.0195 0 6.4YNL229C_Skud1866.4.fasta YNL229C URE2 2.0E+03 0.0191 0.0038 5.4YKL176C_Skud1782.5.fasta YKL176C LST4 2.0E+03 0.02 0.0023 13.4YML004C_Skud2043.5.fasta YML004C GLO1 2.0E+03 0.0185 0.0016 6.1YJL205C-A_Skud1389.3.fasta YJL205C-A 2.0E+03 0 0 0.0YLR240W_Skud1869.3.fasta YLR240W VPS34 2.0E+03 0.0199 0.0025 18.2YNL138W_Skud1855.4.fasta YNL138W SRV2 2.0E+03 0.0198 0.0028 9.4YJL190C_Skud1987.7.fasta YJL190C RPS22A 2.0E+03 0.0149 0 2.0YHR107C_Skud2024.12.fasta YHR107C CDC12 2.0E+03 0.0185 0.0012 7.0YBR223C_Skud1244.1.fasta YBR223C TDP1 2.0E+03 0.0197 0.0064 8.4YDR305C_Skud1967.7.fasta YDR305C HNT2 2.0E+03 0.0155 0.0064 2.1YMR054W_Skud1978.3.fasta YMR054W STV1 2.0E+03 0.0205 0.0021 15.8YEL006W_Skud1494.2.fasta YEL006W YEA6 2.0E+03 0.0183 0.0014 5.2YMR303C_Skud1351.2.fasta YMR303C ADH2 2.0E+03 0.019 0.0013 5.4YLR403W_Skud2066.17.fasta YLR403W SFP1 2.0E+03 0.02 0.0034 11.5YIL140W_Skud1832.4.fasta YIL140W AXL2 2.0E+03 0.0201 0.0091 13.5YOR210W_Skud1769.6.fasta YOR210W RPB10 2.0E+03 0 0 0.0YLR357W_Skud1319.2.fasta YLR357W RSC2 2.0E+03 0.0201 0.0038 16.5YLR453C_Skud1420.3.fasta YLR453C RIF2 2.0E+03 0.0189 0.0078 7.2YOR178C_Skud2050.1.fasta YOR178C GAC1 2.0E+03 0.02 0.0077 15.4YHR018C_Skud2067.2.fasta YHR018C ARG4 2.0E+03 0.0199 0 6.6

YBR299W_Skud1970.8.fasta YBR299W MAL32 2.0E+03 0.0198 0.0025 9.5YMR175W_Skud1860.3.fasta YMR175W SIP18 2.0E+03 0.0121 0.0069 1.0YNL117W_Skud1364.3.fasta YNL117W MLS1 2.0E+03 0.0196 0.0017 8.4YJL183W_Skud1825.7.fasta YJL183W MNN11 2.0E+03 0.0187 0.0012 8.0YDR068W_Skud1900.8.fasta YDR068W DOS2 2.0E+03 0.0178 0.0081 4.2YKR056W_Skud1873.2.fasta YKR056W TRM2 2.0E+03 0.0192 0.004 10.1YGR005C_Skud1104.2.fasta YGR005C TFG2 2.0E+03 0.0174 0 4.1YMR199W_Skud1482.3.fasta YMR199W CLN1 2.0E+03 0.0198 0.0017 9.5YBR260C_Skud2064.13.fasta YBR260C RGD1 2.0E+03 0.0192 0.0008 12.0YDR441C_Skud1894.2.fasta YDR441C APT2 2.0E+03 0.0176 0.0079 2.4YHL010C_Skud2034.7.fasta YHL010C BRP2 2.0E+03 0.0191 0.0056 9.2YDR252W_Skud1915.8.fasta YDR252W BTT1 2.0E+03 0.0117 0.0028 1.0YDR088C_Skud1929.9.fasta YDR088C SLU7 2.0E+03 0.0208 0.0093 8.0YCL030C_Skud2072.15.fasta YCL030C HIS4 2.0E+03 0.0201 0.0036 13.6YPR193C_Skud1411.4.fasta YPR193C HPA2 2.0E+03 0.0119 0.0027 1.0YIL016W_Skud1960.6.fasta YIL016W SNL1 2.0E+03 0.0199 0 2.7YBL071W-A_Skud1889.5.fasta YBL071W-A KTI11 2.0E+03 0.0001 0.0057 0.0YGR031W_Skud1665.2.fasta YGR031W 2.0E+03 0.0182 0.0054 5.2YKR002W_Skud1712.2.fasta YKR002W PAP1 2.0E+03 0.0188 0 9.1YBR045C_Skud1853.3.fasta YBR045C GIP1 2.0E+03 0.0189 0.0042 10.0YJL045W_Skud1920.3.fasta YJL045W 2.0E+03 0.0197 0.0045 11.4YNL063W_Skud1596.3.fasta YNL063W MTQ1 2.0E+03 0.0175 0.0014 4.1YJL180C_Skud1825.5.fasta YJL180C ATP12 2.0E+03 0.0172 0.0028 4.1YDR420W_Skud1813.2.fasta YDR420W HKR1 2.1E+03 0.0198 0.0109 25.0YKL207W_Skud1772.5.fasta YKL207W AIM27 2.1E+03 0.0178 0 3.3YLR297W_Skud2059.6.fasta YLR297W 2.1E+03 0.0151 0.0042 2.1YER057C_Skud2039.13.fasta YER057C HMF1 2.1E+03 0.015 0 2.1YPL087W_Skud2058.15.fasta YPL087W YDC1 2.1E+03 0.0181 0.0016 5.2YDR185C_Skud1600.6.fasta YDR185C UPS3 2.1E+03 0.0158 0.0025 2.2YER118C_Skud1856.6.fasta YER118C SHO1 2.1E+03 0.0183 0.0013 6.1YDR496C_Skud1671.3.fasta YDR496C PUF6 2.1E+03 0.0192 0.002 8.3YLR376C_Skud2027.11.fasta YLR376C PSY3 2.1E+03 0.0208 0.0039 4.9_Skud1512.2.fasta 2.1E+03 0.0178 0.0115 4.2YIL065C_Skud1784.7.fasta YIL065C FIS1 2.1E+03 0.0226 0 2.0YBL042C_Skud1851.3.fasta YBL042C FUI1 2.1E+03 0.0191 0.0045 10.2YNL210W_Skud1629.4.fasta YNL210W MER1 2.1E+03 0.0172 0.0035 4.1YNL252C_Skud1557.5.fasta YNL252C MRPL17 2.1E+03 0.0171 0.0016 4.1YJL208C_Skud1990.2.fasta YJL208C NUC1 2.1E+03 0.0182 0.005 3.4YDR485C_Skud1730.7.fasta YDR485C VPS72 2.1E+03 0.0193 0.0037 15.0YDR240C_Skud2069.13.fasta YDR240C SNU56 2.1E+03 0.019 0.0118 8.3YKL083W_Skud651.3.fasta YKL083W 2.1E+03 0.0167 0.0095 3.1YER024W_Skud1593.3.fasta YER024W YAT2 2.1E+03 0.0196 0.0041 15.3YEL057C_Skud1923.3.fasta YEL057C 2.1E+03 0.0159 0.002 3.0YLR017W_Skud2025.8.fasta YLR017W MEU1 2.1E+03 0.0184 0 5.3YLR127C_Skud1611.4.fasta YLR127C APC2 2.1E+03 0.0205 0.005 15.0YLR398C_Skud2066.13.fasta YLR398C SKI2 2.1E+03 0.0202 0.0047 12.8YBL040C_Skud1851.5.fasta YBL040C ERD2 2.1E+03 0.0131 0 1.2YML100W_Skud1950.7.fasta YML100W TSL1 2.1E+03 0.02 0.0016 15.6YNL009W_Skud1566.1.fasta YNL009W IDP3 2.1E+03 0.0193 0.0031 5.6YML081C-A_Skud1623.2.fasta YML081C-A ATP18 2.1E+03 0 0 0.0YLR251W_Skud1857.2.fasta YLR251W SYM1 2.1E+03 0.0161 0 3.1YPR067W_Skud1509.3.fasta YPR067W ISA2 2.1E+03 0.0147 0.0101 2.1YAL020C_Skud655.1.fasta YAL020C ATS1 2.1E+03 0.0177 0.0135 5.1

YFL040W_Skud1695.5.fasta YFL040W 2.1E+03 0.0193 0.0017 9.4YGL037C_Skud2052.14.fasta YGL037C PNC1 2.1E+03 0.0164 0.0045 3.1YDR379C-A_Skud1468.3.fasta YDR379C-A 2.1E+03 0.0217 0 1.9YDR489W_Skud1171.2.fasta YDR489W SLD5 2.1E+03 0.0117 0.0101 1.0YMR203W_Skud1878.4.fasta YMR203W TOM40 2.1E+03 0.0206 0 8.0YOL126C_Skud2006.10.fasta YOL126C MDH2 2.1E+03 0.0184 0.0014 7.1YCL009C_Skud1939.2.fasta YCL009C ILV6 2.1E+03 0.0175 0.0013 5.1YLR284C_Skud2059.18.fasta YLR284C ECI1 2.1E+03 0.0202 0 5.8YNL155W_Skud1023.2.fasta YNL155W 2.1E+03 0.0201 0.0019 5.8YJL066C_Skud1625.5.fasta YJL066C MPM1 2.1E+03 0.0163 0.0018 3.1YPR139C_Skud2053.10.fasta YPR139C VPS66 2.1E+03 0.017 0.0031 4.1YHR043C_Skud1151.2.fasta YHR043C DOG2 2.1E+03 0.0168 0.0037 3.2YLR223C_Skud1998.6.fasta YLR223C IFH1 2.1E+03 0.0181 0.0024 6.1YLR038C_Skud1946.5.fasta YLR038C COX12 2.1E+03 0.0118 0 1.1YBR189W_Skud773.1.fasta YBR189W RPS9B 2.1E+03 0 0 0.0YGL231C_Skud1511.2.fasta YGL231C EMC4 2.1E+03 0.0163 0.0046 2.3YLR147C_Skud1736.5.fasta YLR147C SMD3 2.1E+03 0.0114 0 1.0YKL127W_Skud1719.4.fasta YKL127W PGM1 2.1E+03 0.019 0.0019 6.5YPL165C_Skud2033.3.fasta YPL165C SET6 2.1E+03 0.0181 0.0026 6.1YIR035C_Skud564.1.fasta YIR035C 2.1E+03 0.0162 0.0055 3.1YJL140W_Skud2041.8.fasta YJL140W RPB4 2.1E+03 0.0203 0 4.9YLL063C_Skud1882.2.fasta YLL063C AYT1 2.1E+03 0.018 0.0168 5.2YOR311C_Skud1795.3.fasta YOR311C DGK1 2.1E+03 0.0174 0.0049 4.2YDL071C_Skud1991.12.fasta YDL071C 2.1E+03 0.0114 0.0133 1.0YOR337W_Skud2005.6.fasta YOR337W TEA1 2.1E+03 0.019 0.0037 12.1YPL144W_Skud1644.3.fasta YPL144W POC4 2.1E+03 0.0146 0.0132 2.1YMR061W_Skud1449.4.fasta YMR061W RNA14 2.1E+03 0.0112 0 1.0YOL130W_Skud2006.6.fasta YOL130W ALR1 2.1E+03 0.0199 0.0011 13.7YOR298W_Skud1320.3.fasta YOR298W MUM3 2.1E+03 0.0201 0.0024 4.8YGR233C_Skud1935.8.fasta YGR233C PHO81 2.1E+03 0.0197 0.0016 17.4YKL132C_Skud1555.3.fasta YKL132C RMA1 2.1E+03 0.0179 0.0132 6.1YHR100C_Skud1294.3.fasta YHR100C GEP4 2.1E+03 0.016 0 3.1YPL061W_Skud1974.4.fasta YPL061W ALD6 2.1E+03 0.0143 0 2.0YKR020W_Skud2000.11.fasta YKR020W VPS51 2.1E+03 0.0142 0.0058 2.0YBR182C_Skud1785.6.fasta YBR182C SMP1 2.1E+03 0.0184 0.0063 5.4YGL089C_Skud1808.6.fasta YGL089C MF(ALPHA)2 2.1E+03 0.0117 0.0123 1.1YGR195W_Skud1691.5.fasta YGR195W SKI6 2.1E+03 0.0206 0 5.0YML048W_Skud1980.9.fasta YML048W GSF2 2.1E+03 0.0181 0.0035 6.2YPL066W_Skud1974.8.fasta YPL066W 2.1E+03 0.0183 0.0087 1.7YNL326C_Skud1653.4.fasta YNL326C PFA3 2.1E+03 0.0179 0.0113 5.2YPL166W_Skud2033.2.fasta YPL166W ATG29 2.1E+03 0.0144 0.002 2.0YDR224C_Skud1379.4.fasta YDR224C HTB1 2.1E+03 0.0145 0 2.1YNR057C_Skud1943.2.fasta YNR057C BIO4 2.1E+03 0.0157 0 3.0YPL259C_Skud302.3.fasta YPL259C APM1 2.1E+03 0.0181 0.005 7.1YPL109C_Skud1710.2.fasta YPL109C 2.1E+03 0.019 0.0048 10.3YOR334W_Skud2005.3.fasta YOR334W MRS2 2.1E+03 0.0123 0.0438 1.1YDR383C_Skud1592.3.fasta YDR383C NKP1 2.1E+03 0.0203 0.0022 4.9YNL299W_Skud1872.6.fasta YNL299W TRF5 2.1E+03 0.0189 0.0044 10.2YDR364C_Skud1964.10.fasta YDR364C CDC40 2.1E+03 0.0183 0.0073 6.3YGR080W_Skud1797.4.fasta YGR080W TWF1 2.1E+03 0.0173 0.0053 4.2YHR161C_Skud1735.6.fasta YHR161C YAP1801 2.1E+03 0.0188 0.0049 11.1YNR032C-A_Skud640.2.fasta YNR032C-A HUB1 2.1E+03 0 0 0.0YBR103W_Skud1637.1.fasta YBR103W SIF2 2.1E+03 0.019 0.0036 9.4

YPL186C_Skud1230.3.fasta YPL186C UIP4 2.1E+03 0.017 0.003 4.1YDR119W_Skud1927.9.fasta YDR119W VBA4 2.2E+03 0.0191 0.0052 13.2YKL191W_Skud1765.4.fasta YKL191W DPH2 2.2E+03 0.0185 0.0038 9.1YHR216W_Skud1996.2.fasta YHR216W IMD2 2.2E+03 0.0001 0.0058 0.0YPL011C_Skud1619.2.fasta YPL011C TAF3 2.2E+03 0.0176 0.0055 5.2YDR309C_Skud1967.3.fasta YDR309C GIC2 2.2E+03 0.0161 0.0038 3.1YKR100C_Skud2028.6.fasta YKR100C SKG1 2.2E+03 0.0175 0.0065 5.2YPL187W_Skud1230.2.fasta YPL187W MF(ALPHA)1 2.2E+03 0.0152 0.0029 2.2YPR200C_Skud1995.2.fasta YPR200C ARR2 2.2E+03 0.0113 0.0068 1.0YDR363W-A_Skud1964.9.fasta YDR363W-A SEM1 2.2E+03 0 0 0.0YJR010W_Skud1955.7.fasta YJR010W MET3 2.2E+03 0.0187 0.0018 7.4YER179W_Skud1901.2.fasta YER179W DMC1 2.2E+03 0.0159 0 3.1YLR373C_Skud2027.8.fasta YLR373C VID22 2.2E+03 0.0193 0.0028 16.2YOR126C_Skud1941.4.fasta YOR126C IAH1 2.2E+03 0.017 0 4.2YDR469W_Skud1959.9.fasta YDR469W SDC1 2.2E+03 0.0208 0.0062 3.0YPR089W_Skud1982.8.fasta YPR089W 2.2E+03 0.0192 0.0011 14.2YPR090W_Skud1982.9.fasta YPR090W 2.2E+03 0.0192 0.0011 14.2YLR375W_Skud2027.10.fasta YLR375W STP3 2.2E+03 0.0172 0.0013 4.2YGR132C_Skud1500.3.fasta YGR132C PHB1 2.2E+03 0.0165 0.0017 4.0YGL055W_Skud768.1.fasta YGL055W OLE1 2.2E+03 0.0197 0.0008 5.8YDL130W-A_Skud1961.11.fasta YDL130W-A STF1 2.2E+03 0.0211 0 2.0YGL048C_Skud1607.1.fasta YGL048C RPT6 2.2E+03 0.0179 0 7.1YPR060C_Skud1546.5.fasta YPR060C ARO7 2.2E+03 0.0201 0 4.9_Skud1996.9.fasta 2.2E+03 0 0 0.0YOL104C_Skud1755.2.fasta YOL104C NDJ1 2.2E+03 0.0199 0.0106 6.9_Skud1975.2.fasta 2.2E+03 0.0002 0.0243 0.0_Skud1975.3.fasta 2.2E+03 0.0002 0.0243 0.0YNL230C_Skud1866.3.fasta YNL230C ELA1 2.2E+03 0.0173 0.0024 5.1YEL001C_Skud1819.5.fasta YEL001C IRC22 2.2E+03 0.0157 0 3.1YFR012W_Skud1385.4.fasta YFR012W 2.2E+03 0.0186 0.0048 6.4YER116C_Skud1856.4.fasta YER116C SLX8 2.2E+03 0.0169 0.0144 4.2YOR128C_Skud1941.6.fasta YOR128C ADE2 2.2E+03 0.0192 0.0024 8.6YIL158W_Skud1026.3.fasta YIL158W AIM20 2.2E+03 0.0149 0.0155 2.2YLR323C_Skud756.2.fasta YLR323C CWC24 2.2E+03 0.0207 0.0048 3.0YLR026C_Skud1684.2.fasta YLR026C SED5 2.2E+03 0.0167 0.0012 3.3YMR104C_Skud1332.3.fasta YMR104C YPK2 2.2E+03 0.0187 0.0042 11.1YKL187C_Skud1844.4.fasta YKL187C 2.2E+03 0.02 0.0021 13.9YML018C_Skud2017.10.fasta YML018C 2.2E+03 0.0182 0.0011 5.4YPL065W_Skud1974.7.fasta YPL065W VPS28 2.2E+03 0.017 0.003 4.2YER127W_Skud1822.6.fasta YER127W LCP5 2.2E+03 0.017 0.0026 5.0YGL083W_Skud2057.2.fasta YGL083W SCY1 2.2E+03 0.0201 0.0033 15.0YNR017W_Skud1660.2.fasta YNR017W TIM23 2.2E+03 0.0202 0.0022 4.0YDR373W_Skud1687.3.fasta YDR373W FRQ1 2.2E+03 0.0159 0 3.1YCL049C_Skud2065.4.fasta YCL049C 2.2E+03 0.0174 0.0049 5.2YHR147C_Skud1820.1.fasta YHR147C MRPL6 2.2E+03 0.0154 0.0023 3.0YBR153W_Skud2051.6.fasta YBR153W RIB7 2.2E+03 0.0161 0.0019 3.2YGL224C_Skud1804.6.fasta YGL224C SDT1 2.2E+03 0.016 0 3.2YHR121W_Skud1988.3.fasta YHR121W LSM12 2.2E+03 0.0195 0.0109 2.8YGL045W_Skud1607.4.fasta YGL045W RIM8 2.2E+03 0.0186 0.0018 9.3YGL046W_Skud1607.3.fasta YGL046W 2.2E+03 0.0186 0.0018 9.3YDL030W_Skud1646.5.fasta YDL030W PRP9 2.2E+03 0 0 0.0YCL040W_Skud2072.5.fasta YCL040W GLK1 2.2E+03 0.0194 0 6.8YDR474C_Skud1959.4.fasta YDR474C 2.2E+03 0.0199 0.0118 15.9

YDR475C_Skud1959.3.fasta YDR475C JIP4 2.2E+03 0.0199 0.0118 15.9YPR163C_Skud1949.3.fasta YPR163C TIF3 2.2E+03 0.0184 0.001 6.4YGR193C_Skud1691.3.fasta YGR193C PDX1 2.2E+03 0.0174 0.0057 6.1YLR213C_Skud1821.2.fasta YLR213C CRR1 2.2E+03 0.0183 0.0035 7.3YKL053C-A_Skud2056.12.fasta YKL053C-A MDM35 2.2E+03 0 0 0.0YLR113W_Skud2004.7.fasta YLR113W HOG1 2.2E+03 0.018 0.0012 7.2YBR139W_Skud1278.2.fasta YBR139W 2.2E+03 0.0116 0.0055 1.1YHR117W_Skud2024.2.fasta YHR117W TOM71 2.2E+03 0.0186 0.0055 11.2YJL199C_Skud1642.3.fasta YJL199C MBB1 2.2E+03 0.0107 0 1.0YBR239C_Skud1387.1.fasta YBR239C ERT1 2.2E+03 0.0139 0 2.0YGR188C_Skud1313.2.fasta YGR188C BUB1 2.2E+03 0.011 0.0092 1.1YKL155C_Skud1487.2.fasta YKL155C RSM22 2.2E+03 0.0182 0.0051 9.1YGR033C_Skud1926.2.fasta YGR033C TIM21 2.2E+03 0.0144 0.0069 2.1YDR183W_Skud1600.4.fasta YDR183W PLP1 2.2E+03 0.0196 0 3.9YCR090C_Skud1696.2.fasta YCR090C 2.2E+03 0.0152 0.0029 3.0YER086W_Skud1635.4.fasta YER086W ILV1 2.2E+03 0.0189 0 7.6YNL166C_Skud1953.5.fasta YNL166C BNI5 2.2E+03 0.0179 0.0055 7.2YBR293W_Skud1455.3.fasta YBR293W VBA2 2.2E+03 0.0182 0.0059 8.2YCL067C_Skud1781.3.fasta YCL067C HMLALPHA2 2.2E+03 0 0 0.0YIL021W_Skud761.2.fasta YIL021W RPB3 2.2E+03 0.0172 0 4.3YDL092W_Skud1213.2.fasta YDL092W SRP14 2.2E+03 0.0199 0.0036 2.9YHR025W_Skud855.2.fasta YHR025W THR1 2.2E+03 0.0161 0.0037 3.2YFR053C_Skud1972.2.fasta YFR053C HXK1 2.2E+03 0.0188 0 6.6YFR052W_Skud1972.3.fasta YFR052W RPN12 2.2E+03 0.0196 0.002 5.9YPR154W_Skud556.1.fasta YPR154W PIN3 2.2E+03 0.0145 0.0043 2.1YML043C_Skud1980.6.fasta YML043C RRN11 2.2E+03 0.0183 0.0062 7.4YEL020W-A_Skud1858.6.fasta YEL020W-A TIM9 2.2E+03 0.0201 0 1.9YLR262C_Skud1971.6.fasta YLR262C YPT6 2.2E+03 0.0154 0 3.1YCR097W_Skud2040.6.fasta YCR097W HMRA1 2.2E+03 0.0219 0 1.0YPL096C-A_Skud2058.5.fasta YPL096C-A ERI1 2.2E+03 0 0 0.0YCL047C_Skud2065.2.fasta YCL047C 2.2E+03 0.0157 0.0122 3.1YLR452C_Skud1420.2.fasta YLR452C SST2 2.2E+03 0.0191 0 5.8YKR037C_Skud1606.6.fasta YKR037C SPC34 2.2E+03 0.0164 0.0015 4.1_Skud1992.4.fasta 2.2E+03 0 0 0.0YDR035W_Skud2038.9.fasta YDR035W ARO3 2.2E+03 0.0172 0.0027 6.1YOR292C_Skud1838.4.fasta YOR292C 2.2E+03 0.0179 0.0065 5.4YPR086W_Skud1982.6.fasta YPR086W SUA7 2.2E+03 0.0166 0 4.2YPL156C_Skud2033.12.fasta YPL156C PRM4 2.2E+03 0.0199 0.005 5.0YOR104W_Skud2018.8.fasta YOR104W PIN2 2.2E+03 0.0157 0.011 3.1YKL096W-A_Skud1520.4.fasta YKL096W-A CWP2 2.2E+03 0.0191 0 1.8YLR012C_Skud2025.13.fasta YLR012C 2.2E+03 0.0112 0 1.1YKL138C-A_Skud1823.5.fasta YKL138C-A HSK3 2.2E+03 0 0 0.0YOR209C_Skud1769.7.fasta YOR209C NPT1 2.2E+03 0.011 0.0027 1.1YNL222W_Skud1747.4.fasta YNL222W SSU72 2.2E+03 0.0154 0 3.1YNL189W_Skud1698.3.fasta YNL189W SRP1 2.2E+03 0.0184 0.0008 7.4YDR234W_Skud2069.7.fasta YDR234W LYS4 2.3E+03 0.0188 0 11.4YPL005W_Skud1777.2.fasta YPL005W AEP3 2.3E+03 0 0.0043 0.0YDR235W_Skud2069.8.fasta YDR235W PRP42 2.3E+03 0.0184 0.0101 10.2YBR031W_Skud2061.8.fasta YBR031W RPL4A 2.3E+03 0 0 0.0YOR354C_Skud1930.5.fasta YOR354C MSC6 2.3E+03 0.0187 0.0032 10.4YHR184W_Skud2046.4.fasta YHR184W SSP1 2.3E+03 0.0182 0.0015 7.3YLR374C_Skud2027.9.fasta YLR374C 2.3E+03 0 0 0.0YPL170W_Skud1669.5.fasta YPL170W DAP1 2.3E+03 0.02 0 3.0

YLL023C_Skud1036.2.fasta YLL023C 2.3E+03 0.0162 0.0036 4.1YLR457C_Skud1885.4.fasta YLR457C NBP1 2.3E+03 0.0161 0.0028 4.1YDR184C_Skud1600.5.fasta YDR184C ATC1 2.3E+03 0.0166 0.0016 4.2YJR075W_Skud1916.9.fasta YJR075W HOC1 2.3E+03 0.0166 0 4.2YML037C_Skud1957.7.fasta YML037C 2.3E+03 0.0166 0.0071 5.0YJR010C-A_Skud1955.6.fasta YJR010C-A SPC1 2.3E+03 0.0106 0.0057 1.0YBR265W_Skud2064.8.fasta YBR265W TSC10 2.3E+03 0.0164 0 4.1YOL092W_Skud1742.4.fasta YOL092W 2.3E+03 0.0163 0 4.1YBR151W_Skud2051.8.fasta YBR151W APD1 2.3E+03 0.0156 0.0013 3.1YER114C_Skud1856.2.fasta YER114C BOI2 2.3E+03 0.0197 0.0058 16.8YJL106W_Skud1954.5.fasta YJL106W IME2 2.3E+03 0.0185 0.0021 9.4YIR027C_Skud1859.5.fasta YIR027C DAL1 2.3E+03 0.0181 0.0063 7.3YCR034W_Skud2035.7.fasta YCR034W FEN1 2.3E+03 0.0162 0 4.1YNL003C_Skud1029.1.fasta YNL003C PET8 2.3E+03 0.0163 0 4.1YDR346C_Skud1649.4.fasta YDR346C SVF1 2.3E+03 0.0183 0.0031 8.3YDR505C_Skud1891.2.fasta YDR505C PSP1 2.3E+03 0.0187 0.0011 11.3YJR072C_Skud1916.6.fasta YJR072C NPA3 2.3E+03 0.0168 0 4.3YHR072W_Skud1817.4.fasta YHR072W ERG7 2.3E+03 0.019 0.0012 10.6YER142C_Skud1631.5.fasta YER142C MAG1 2.3E+03 0.0166 0.0089 5.1YER007W_Skud1540.3.fasta YER007W PAC2 2.3E+03 0.0196 0.0091 8.0YOR114W_Skud1174.2.fasta YOR114W 2.3E+03 0.0169 0.0032 4.3YPL199C_Skud1659.6.fasta YPL199C 2.3E+03 0.0161 0.0022 4.1YLR224W_Skud1998.5.fasta YLR224W 2.3E+03 0.017 0.0055 6.0YER007C-A_Skud1540.2.fasta YER007C-A TMA20 2.3E+03 0 0 0.0YPR110C_Skud1108.1.fasta YPR110C RPC40 2.3E+03 0.0166 0.0026 3.4YMR285C_Skud1713.3.fasta YMR285C NGL2 2.3E+03 0.0182 0.0044 7.4YGR012W_Skud1670.2.fasta YGR012W 2.3E+03 0.0168 0 5.1YLR010C_Skud2025.15.fasta YLR010C TEN1 2.3E+03 0.0136 0.019 2.1YKR091W_Skud1223.2.fasta YKR091W SRL3 2.3E+03 0.016 0.0038 4.1YLR363C_Skud1678.2.fasta YLR363C NMD4 2.3E+03 0.0193 0 3.9YDR217C_Skud1811.1.fasta YDR217C RAD9 2.3E+03 0.0198 0.0084 20.9YBR278W_Skud1134.2.fasta YBR278W DPB3 2.3E+03 0.0148 0.0125 3.0YOL068C_Skud1212.2.fasta YOL068C HST1 2.3E+03 0.0195 0.0032 8.9YNL181W_Skud942.1.fasta YNL181W 2.3E+03 0.0195 0.0024 7.0YDR232W_Skud2069.5.fasta YDR232W HEM1 2.3E+03 0.018 0 9.2_Skud1931.8.fasta 2.3E+03 0.011 0.0038 1.1YMR124W_Skud2044.9.fasta YMR124W 2.3E+03 0.0194 0.0076 16.7YPL095C_Skud2058.7.fasta YPL095C EEB1 2.3E+03 0.0174 0.001 6.2YOR342C_Skud1945.2.fasta YOR342C 2.3E+03 0.0168 0.0031 5.1YKR013W_Skud2000.4.fasta YKR013W PRY2 2.3E+03 0.0171 0.0108 5.2YCL027W_Skud2072.18.fasta YCL027W FUS1 2.3E+03 0.0178 0.0055 7.3YMR263W_Skud2070.20.fasta YMR263W SAP30 2.3E+03 0.0134 0.0051 2.0YMR188C_Skud1731.2.fasta YMR188C MRPS17 2.3E+03 0.0189 0.0041 3.9YGR172C_Skud2063.4.fasta YGR172C YIP1 2.3E+03 0.0149 0.0039 3.0YNL194C_Skud1800.4.fasta YNL194C 2.3E+03 0.0157 0.003 3.2YMR152W_Skud1956.11.fasta YMR152W YIM1 2.3E+03 0.0173 0.0078 6.2YIL103W_Skud1790.1.fasta YIL103W DPH1 2.3E+03 0.0171 0.0021 5.3YER028C_Skud1757.2.fasta YER028C MIG3 2.3E+03 0.0172 0.0081 5.3YIL051C_Skud1375.2.fasta YIL051C MMF1 2.3E+03 0.0132 0 2.0YDR086C_Skud1929.7.fasta YDR086C SSS1 2.3E+03 0 0 0.0YCL018W_Skud2072.24.fasta YCL018W LEU2 2.3E+03 0.0195 0.0014 7.0YPR133C_Skud2053.3.fasta YPR133C SPN1 2.3E+03 0.0193 0.0023 6.9YGL253W_Skud1439.3.fasta YGL253W HXK2 2.3E+03 0.0175 0.0035 7.2

YBL064C_Skud1889.10.fasta YBL064C PRX1 2.3E+03 0.0194 0 5.0YNL052W_Skud1564.3.fasta YNL052W COX5A 2.3E+03 0.0134 0 2.1YDR352W_Skud2047.12.fasta YDR352W 2.3E+03 0.0161 0.0102 4.1YBR283C_Skud1898.7.fasta YBR283C SSH1 2.3E+03 0.0189 0.0009 6.8YMR005W_Skud2043.13.fasta YMR005W TAF4 2.3E+03 0.0167 0.006 5.2YAL001C_Skud1550.2.fasta YAL001C TFC3 2.3E+03 0.0189 0.0024 17.3YOR303W_Skud1580.2.fasta YOR303W CPA1 2.3E+03 0.0175 0.0035 6.3YPR192W_Skud1411.3.fasta YPR192W AQY1 2.3E+03 0.0191 0.0032 4.9YPR021C_Skud1887.7.fasta YPR021C AGC1 2.3E+03 0.0184 0.0032 14.1YGR048W_Skud2031.11.fasta YGR048W UFD1 2.3E+03 0.017 0.0012 4.4YIL067C_Skud1784.9.fasta YIL067C 2.3E+03 0.0186 0.0033 9.5YER104W_Skud2009.2.fasta YER104W RTT105 2.3E+03 0.0149 0.0073 3.1YDL103C_Skud1235.2.fasta YDL103C QRI1 2.3E+03 0.0156 0.0041 3.2YML121W_Skud1679.4.fasta YML121W GTR1 2.3E+03 0.0188 0 5.8YLR005W_Skud1904.2.fasta YLR005W SSL1 2.3E+03 0.0171 0 6.2YLR381W_Skud1273.1.fasta YLR381W CTF3 2.3E+03 0.0194 0.0043 13.9YOR224C_Skud1729.4.fasta YOR224C RPB8 2.3E+03 0.013 0.0037 2.0YPL107W_Skud1710.5.fasta YPL107W 2.3E+03 0.0148 0.0036 3.1YAL054C_Skud1874.6.fasta YAL054C ACS1 2.3E+03 0.0183 0.0007 12.2YGR237C_Skud1935.4.fasta YGR237C 2.3E+03 0.0193 0.004 11.9YLR039C_Skud1946.6.fasta YLR039C RIC1 2.4E+03 0.0188 0.0032 15.4YNL086W_Skud1131.2.fasta YNL086W 2.4E+03 0 0 0.0YOL083W_Skud1472.1.fasta YOL083W 2.4E+03 0.017 0.0119 5.3YIL062C_Skud1784.4.fasta YIL062C ARC15 2.4E+03 0.013 0 2.0_Skud1846.2.fasta 2.4E+03 0.0002 0.0158 0.0YKL161C_Skud1554.3.fasta YKL161C 2.4E+03 0.0174 0.0026 6.3YPR104C_Skud1693.6.fasta YPR104C FHL1 2.4E+03 0.0191 0.0038 13.7YMR105C_Skud1332.4.fasta YMR105C PGM2 2.4E+03 0.0178 0 10.1YIR026C_Skud1859.4.fasta YIR026C YVH1 2.4E+03 0.0169 0 6.1YBR155W_Skud2051.4.fasta YBR155W CNS1 2.4E+03 0.016 0.0022 4.2YIL134W_Skud1475.2.fasta YIL134W FLX1 2.4E+03 0.0191 0.0058 6.0YEL004W_Skud1494.4.fasta YEL004W YEA4 2.4E+03 0.0167 0.0086 5.2YKR099W_Skud2028.5.fasta YKR099W BAS1 2.4E+03 0.0188 0.0018 14.4YDR218C_Skud1811.2.fasta YDR218C SPR28 2.4E+03 0.0167 0.0054 5.2YIL105C_Skud1790.3.fasta YIL105C SLM1 2.4E+03 0.0182 0.0022 11.2YER087W_Skud1635.5.fasta YER087W AIM10 2.4E+03 0.0178 0.0048 8.3YHR157W_Skud1735.2.fasta YHR157W REC104 2.4E+03 0.0135 0.0048 2.1YBR243C_Skud1651.4.fasta YBR243C ALG7 2.4E+03 0.019 0 8.9YFR050C_Skud1972.5.fasta YFR050C PRE4 2.4E+03 0.016 0.0019 4.2YMR021C_Skud1286.3.fasta YMR021C MAC1 2.4E+03 0.0171 0.0013 6.2_Skud1979.3.fasta 2.4E+03 0.0182 0 9.4YOR310C_Skud1795.2.fasta YOR310C NOP58 2.4E+03 0.0174 0.0053 8.1YNL236W_Skud1688.3.fasta YNL236W SIN4 2.4E+03 0.0188 0.0005 14.5YKL005C_Skud1788.5.fasta YKL005C BYE1 2.4E+03 0.0173 0.0055 8.1YBL056W_Skud1907.8.fasta YBL056W PTC3 2.4E+03 0.0169 0.002 6.2YDL207W_Skud1850.3.fasta YDL207W GLE1 2.4E+03 0.0176 0.0032 6.4YPL239W_Skud1905.2.fasta YPL239W YAR1 2.4E+03 0.0131 0.0023 2.1YER016W_Skud1461.3.fasta YER016W BIM1 2.4E+03 0.0158 0.004 4.1YPL236C_Skud1578.6.fasta YPL236C ENV7 2.4E+03 0.0164 0.0013 5.2YPL249C-A_Skud302.11.fasta YPL249C-A RPL36B 2.4E+03 0 0 0.0YLR220W_Skud1998.9.fasta YLR220W CCC1 2.4E+03 0.0161 0.0072 4.2YNR014W_Skud1185.2.fasta YNR014W 2.4E+03 0.0186 0.0124 5.9YFL010C_Skud1910.4.fasta YFL010C WWM1 2.4E+03 0.0151 0.0083 3.2

YMR065W_Skud1172.2.fasta YMR065W KAR5 2.4E+03 0.0171 0.0047 7.1YCL004W_Skud1939.6.fasta YCL004W PGS1 2.4E+03 0.0174 0.0027 7.3YDR511W_Skud1416.3.fasta YDR511W ACN9 2.4E+03 0.0128 0.0084 2.0YNL153C_Skud1924.2.fasta YNL153C GIM3 2.4E+03 0.0189 0.0047 3.0YLR262C-A_Skud1971.7.fasta YLR262C-A TMA7 2.4E+03 0.0189 0 0.9YDL045W-A_Skud1386.3.fasta YDL045W-A MRP10 2.4E+03 0 0 0.0YJL091C_Skud1640.3.fasta YJL091C GWT1 2.4E+03 0.0188 0.0053 8.8YHL020C_Skud1229.2.fasta YHL020C OPI1 2.4E+03 0.0183 0.0024 5.8YDR449C_Skud1894.9.fasta YDR449C UTP6 2.4E+03 0.016 0.002 5.1YKR018C_Skud2000.9.fasta YKR018C 2.4E+03 0.0181 0.0013 11.3YDL199C_Skud1535.4.fasta YDL199C 2.4E+03 0.018 0.0057 11.2YDR070C_Skud1900.10.fasta YDR070C FMP16 2.4E+03 0.019 0 2.0YGR216C_Skud1708.2.fasta YGR216C GPI1 2.4E+03 0.0177 0.0037 8.3YMR069W_Skud1522.2.fasta YMR069W NAT4 2.4E+03 0.0001 0.0085 0.0YLR397C_Skud2066.12.fasta YLR397C AFG2 2.4E+03 0.0187 0.003 11.7YBR109C_Skud1877.7.fasta YBR109C CMD1 2.4E+03 0.0112 0.0029 1.2YNR018W_Skud1660.3.fasta YNR018W AIM38 2.4E+03 0.0131 0.0041 2.1YDR448W_Skud1894.8.fasta YDR448W ADA2 2.4E+03 0.0167 0 5.3YKL081W_Skud1563.2.fasta YKL081W TEF4 2.4E+03 0.0161 0.0015 4.3YPR191W_Skud1411.2.fasta YPR191W QCR2 2.4E+03 0.0188 0.004 6.0YNL128W_Skud1749.2.fasta YNL128W TEP1 2.4E+03 0.0167 0 5.3YMR083W_Skud1917.3.fasta YMR083W ADH3 2.4E+03 0.0167 0.0014 6.2YIL121W_Skud1925.7.fasta YIL121W QDR2 2.4E+03 0.0177 0.0049 9.2YFL060C_Skud1484.2.fasta YFL060C SNO3 2.4E+03 0.0096 0.0054 1.0YHR199C_Skud1913.9.fasta YHR199C AIM46 2.4E+03 0.0151 0.0077 4.0YGL033W_Skud2052.10.fasta YGL033W HOP2 2.4E+03 0.0188 0 2.0YHR134W_Skud2014.13.fasta YHR134W WSS1 2.4E+03 0.0144 0.0074 3.1YOR211C_Skud1769.5.fasta YOR211C MGM1 2.4E+03 0.0188 0.0019 11.7YDR005C_Skud1100.4.fasta YDR005C MAF1 2.4E+03 0.0143 0 3.0YPR196W_Skud1448.2.fasta YPR196W 2.4E+03 0.0176 0.0022 8.3YJR048W_Skud715.2.fasta YJR048W CYC1 2.4E+03 0 0 0.0YBR101C_Skud1637.3.fasta YBR101C FES1 2.4E+03 0.0152 0.0034 4.0YGR142W_Skud1517.1.fasta YGR142W BTN2 2.4E+03 0.0159 0.0089 5.1YDR121W_Skud1862.2.fasta YDR121W DPB4 2.4E+03 0.0142 0.0026 3.0YGL153W_Skud2042.12.fasta YGL153W PEX14 2.4E+03 0.0164 0.0015 6.1YAL044C_Skud1247.2.fasta YAL044C GCV3 2.4E+03 0.0098 0.0027 1.0YOR045W_Skud2015.11.fasta YOR045W TOM6 2.4E+03 0.0001 0.0091 0.0YGL205W_Skud1505.2.fasta YGL205W POX1 2.4E+03 0.0179 0.0026 12.1YMR011W_Skud2054.4.fasta YMR011W HXT2 2.4E+03 0.0178 0.0008 7.5YOR172W_Skud2050.8.fasta YOR172W YRM1 2.4E+03 0.0177 0.0053 11.1YNL188W_Skud1698.4.fasta YNL188W KAR1 2.4E+03 0.0164 0.0054 6.1YDL019C_Skud1867.7.fasta YDL019C OSH2 2.4E+03 0.0189 0.0034 17.6YIL034C_Skud1694.4.fasta YIL034C CAP2 2.4E+03 0.0139 0 2.2YDR098C_Skud1801.5.fasta YDR098C GRX3 2.4E+03 0.0129 0.0082 2.1YPR173C_Skud1422.3.fasta YPR173C VPS4 2.4E+03 0.0165 0 6.1YML064C_Skud1576.2.fasta YML064C TEM1 2.4E+03 0.0143 0.0039 3.1YDR531W_Skud2001.10.fasta YDR531W CAB1 2.5E+03 0.0161 0 4.3YJR139C_Skud1942.9.fasta YJR139C HOM6 2.5E+03 0.0161 0.0027 5.1YOR157C_Skud1740.5.fasta YOR157C PUP1 2.5E+03 0.0153 0 4.1YOR099W_Skud2018.12.fasta YOR099W KTR1 2.5E+03 0.0168 0.0104 6.2YLR312W-A_Skud1965.7.fasta YLR312W-A MRPL15 2.5E+03 0.0186 0.0019 4.0YLR264W_Skud1547.3.fasta YLR264W RPS28B 2.5E+03 0 0 0.0YER170W_Skud1123.2.fasta YER170W ADK2 2.5E+03 0.0178 0.0086 3.8

YFR017C_Skud1018.1.fasta YFR017C 2.5E+03 0.0127 0.0024 2.1YKL139W_Skud1823.6.fasta YKL139W CTK1 2.5E+03 0.017 0.0009 7.2YDL192W_Skud1732.2.fasta YDL192W ARF1 2.5E+03 0.0124 0 2.0YNL164C_Skud1953.7.fasta YNL164C IBD2 2.5E+03 0.0152 0.0074 3.3YNL148C_Skud1924.6.fasta YNL148C ALF1 2.5E+03 0.0142 0.004 3.1YOL002C_Skud1890.3.fasta YOL002C IZH2 2.5E+03 0.0152 0.0013 3.3YNL294C_Skud1783.3.fasta YNL294C RIM21 2.5E+03 0.0172 0.0021 9.1YGR206W_Skud1744.3.fasta YGR206W MVB12 2.5E+03 0.0185 0.0051 2.0YLR303W_Skud2059.1.fasta YLR303W MET17 2.5E+03 0.0168 0 4.5YOR266W_Skud1703.4.fasta YOR266W PNT1 2.5E+03 0.0184 0.007 6.9YNL220W_Skud1747.2.fasta YNL220W ADE12 2.5E+03 0.0159 0.001 5.1YCL063W_Skud2065.16.fasta YCL063W VAC17 2.5E+03 0.0167 0.0033 6.2YBR233W-A_Skud1458.3.fasta YBR233W-A DAD3 2.5E+03 0.0094 0 1.0YLR074C_Skud1028.2.fasta YLR074C BUD20 2.5E+03 0.0184 0 2.0YEL059C-A_Skud1923.5.fasta YEL059C-A SOM1 2.5E+03 0 0 0.0YLR414C_Skud1928.5.fasta YLR414C 2.5E+03 0.015 0.0041 4.0YJR008W_Skud1955.9.fasta YJR008W 2.5E+03 0.0157 0.0027 4.2YGR096W_Skud1968.5.fasta YGR096W TPC1 2.5E+03 0.015 0.0031 4.0YDR231C_Skud2069.4.fasta YDR231C COX20 2.5E+03 0.0184 0.0048 3.0YDR047W_Skud1362.1.fasta YDR047W HEM12 2.5E+03 0.0164 0.0059 6.1YMR202W_Skud1878.5.fasta YMR202W ERG2 2.5E+03 0.0135 0.002 2.2YBL030C_Skud2007.9.fasta YBL030C PET9 2.5E+03 0.0156 0.0017 5.0YGL114W_Skud2026.6.fasta YGL114W 2.5E+03 0.0187 0.002 11.8YER167W_Skud1434.2.fasta YER167W BCK2 2.5E+03 0.0185 0.0023 14.5YDR510W_Skud1416.2.fasta YDR510W SMT3 2.5E+03 0 0 0.0YHL004W_Skud2034.12.fasta YHL004W MRP4 2.5E+03 0.0157 0.0012 5.1YKL137W_Skud1823.3.fasta YKL137W CMC1 2.5E+03 0.018 0 2.0YGR124W_Skud1864.5.fasta YGR124W ASN2 2.5E+03 0.0174 0.0018 10.1YMR307W_Skud1541.2.fasta YMR307W GAS1 2.5E+03 0.0153 0.0032 4.1YJL025W_Skud1354.3.fasta YJL025W RRN7 2.5E+03 0.0169 0.0074 7.2YDL129W_Skud1786.8.fasta YDL129W 2.5E+03 0.0148 0.0051 4.0YOR324C_Skud1824.4.fasta YOR324C FRT1 2.5E+03 0.0187 0.0073 9.9YGL031C_Skud2052.8.fasta YGL031C RPL24A 2.5E+03 0.0098 0.0029 1.1YHR105W_Skud2024.14.fasta YHR105W YPT35 2.5E+03 0.0139 0 3.0YOR010C_Skud1310.1.fasta YOR010C TIR2 2.5E+03 0.0138 0.0069 3.0YML122C_Skud1679.5.fasta YML122C 2.5E+03 0 0 0.0YOR043W_Skud2015.9.fasta YOR043W WHI2 2.5E+03 0.0182 0 4.9YKR096W_Skud2028.2.fasta YKR096W ESL2 2.5E+03 0.0189 0.003 17.7YJL179W_Skud1825.4.fasta YJL179W PFD1 2.5E+03 0.0176 0 1.9YBR068C_Skud1650.2.fasta YBR068C BAP2 2.5E+03 0.0177 0.0008 9.4YLR043C_Skud1946.9.fasta YLR043C TRX1 2.5E+03 0.0094 0 1.0YOR167C_Skud2050.11.fasta YOR167C RPS28A 2.5E+03 0 0 0.0YGR247W_Skud1999.11.fasta YGR247W CPD1 2.5E+03 0.0142 0.004 3.1YGR070W_Skud1944.6.fasta YGR070W ROM1 2.5E+03 0.0186 0.0043 16.5YLR409C_Skud2066.23.fasta YLR409C UTP21 2.5E+03 0.0181 0.0036 14.3YGR097W_Skud1968.4.fasta YGR097W ASK10 2.5E+03 0.0185 0.0043 15.5YLR200W_Skud1827.9.fasta YLR200W YKE2 2.5E+03 0.0172 0 1.9_Skud1666.2.fasta 2.5E+03 0 0 0.0YJR060W_Skud1911.4.fasta YJR060W CBF1 2.5E+03 0.0153 0.0051 4.2YMR271C_Skud2070.12.fasta YMR271C URA10 2.5E+03 0.0138 0.0046 3.0YHL023C_Skud1842.4.fasta YHL023C RMD11 2.5E+03 0.0162 0.0064 5.3YLR003C_Skud1904.4.fasta YLR003C CMS1 2.5E+03 0 0.0032 0.0YLR146C_Skud1736.6.fasta YLR146C SPE4 2.5E+03 0.0139 0.0013 2.3

YPR135W_Skud2053.6.fasta YPR135W CTF4 2.5E+03 0.0183 0.0015 13.5YJR022W_Skud1630.5.fasta YJR022W LSM8 2.5E+03 0.0092 0 1.0YBR214W_Skud1615.2.fasta YBR214W SDS24 2.5E+03 0.017 0.0009 8.2YGR086C_Skud1797.10.fasta YGR086C PIL1 2.5E+03 0.0155 0.0031 5.0YDL208W_Skud1850.2.fasta YDL208W NHP2 2.5E+03 0.018 0 3.0YBR197C_Skud1989.7.fasta YBR197C 2.5E+03 0.0126 0.0094 2.1YPR024W_Skud1604.3.fasta YPR024W YME1 2.5E+03 0.0178 0 11.3YOL149W_Skud1876.7.fasta YOL149W DCP1 2.5E+03 0.0124 0.0019 2.1YGR079W_Skud1797.3.fasta YGR079W 2.5E+03 0.0155 0.0121 4.2YGL190C_Skud1778.8.fasta YGL190C CDC55 2.5E+03 0.017 0.0009 8.2YDR239C_Skud2069.12.fasta YDR239C 2.5E+03 0.0177 0.0065 11.3YLR001C_Skud1904.6.fasta YLR001C 2.5E+03 0.0177 0.0027 12.2YMR276W_Skud2070.7.fasta YMR276W DSK2 2.5E+03 0.0098 0.0025 1.1YDR030C_Skud2038.3.fasta YDR030C RAD28 2.5E+03 0.0165 0.0035 6.3YOR283W_Skud1737.8.fasta YOR283W 2.5E+03 0.0142 0.0022 3.1YPL214C_Skud1936.4.fasta YPL214C THI6 2.5E+03 0.017 0.0036 8.2YPR052C_Skud1806.4.fasta YPR052C NHP6A 2.5E+03 0 0 0.0YBL104C_Skud1948.2.fasta YBL104C 2.5E+03 0.0186 0.0009 16.6YPL149W_Skud1266.2.fasta YPL149W ATG5 2.5E+03 0.0138 0.0014 2.3YLR259C_Skud1971.4.fasta YLR259C HSP60 2.5E+03 0.0175 0.0008 8.5YDL045C_Skud1386.2.fasta YDL045C FAD1 2.5E+03 0.0145 0.0029 3.2YJL008C_Skud1552.4.fasta YJL008C CCT8 2.5E+03 0.0173 0 8.4YAL034C-B_Skud1685.5.fasta YAL034C-B 2.5E+03 0 0 0.0YBR058C-A_Skud1976.8.fasta YBR058C-A TSC3 2.5E+03 0 0 0.0YPR148C_Skud2053.17.fasta YPR148C 2.5E+03 0.016 0.0046 6.1YBR058C_Skud1976.9.fasta YBR058C UBP14 2.5E+03 0.0174 0.0037 12.0YBR095C_Skud1359.1.fasta YBR095C RXT2 2.5E+03 0.0156 0 5.1YJL141C_Skud2041.9.fasta YJL141C YAK1 2.5E+03 0.0179 0.0012 12.4YJR034W_Skud826.2.fasta YJR034W PET191 2.5E+03 0.0091 0 1.0YJL147C_Skud2041.14.fasta YJL147C 2.5E+03 0.0179 0.0063 5.9YHR030C_Skud1508.3.fasta YHR030C SLT2 2.5E+03 0.0167 0 8.1YJL093C_Skud1193.2.fasta YJL093C TOK1 2.5E+03 0.0178 0.0042 10.5YNL187W_Skud1698.5.fasta YNL187W SWT21 2.5E+03 0.0163 0.0093 5.4YOR022C_Skud1983.8.fasta YOR022C 2.5E+03 0.0172 0.0049 10.1YBR089C-A_Skud2011.6.fasta YBR089C-A NHP6B 2.5E+03 0.0178 0 2.0YLR193C_Skud1827.3.fasta YLR193C UPS1 2.6E+03 0.0125 0 2.1YLR286C_Skud2059.16.fasta YLR286C CTS1 2.6E+03 0.0167 0.0056 8.1YNL215W_Skud1061.1.fasta YNL215W IES2 2.6E+03 0.0145 0.0089 4.0YKL077W_Skud1436.3.fasta YKL077W 2.6E+03 0.0153 0.0068 4.2YHL034C_Skud1834.2.fasta YHL034C SBP1 2.6E+03 0.0146 0.0016 3.2_Skud1856.5.fasta 2.6E+03 0.0089 0 1.0YGR046W_Skud1839.2.fasta YGR046W TAM41 2.6E+03 0.0182 0.0012 6.0YKR105C_Skud1383.2.fasta YKR105C VBA5 2.6E+03 0.0161 0.0011 5.3YGL121C_Skud2026.13.fasta YGL121C GPG1 2.6E+03 0.0093 0.0116 1.0YOR233W_Skud1805.6.fasta YOR233W KIN4 2.6E+03 0.0177 0.0068 11.4YKL130C_Skud1555.4.fasta YKL130C SHE2 2.6E+03 0.0177 0.004 3.9YKL018C-A_Skud1716.5.fasta YKL018C-A 2.6E+03 0 0 0.0YOR340C_Skud2005.9.fasta YOR340C RPA43 2.6E+03 0.0153 0.0016 5.0YHR087W_Skud1470.4.fasta YHR087W RTC3 2.6E+03 0.009 0 1.0YKL051W_Skud2056.10.fasta YKL051W SFK1 2.6E+03 0.0154 0 4.3YPR158W_Skud1870.4.fasta YPR158W CUR1 2.6E+03 0.015 0.0148 4.1YPR185W_Skud1529.2.fasta YPR185W ATG13 2.6E+03 0.0174 0.003 8.5YBL010C_Skud1914.8.fasta YBL010C 2.6E+03 0.0173 0.0053 3.9

YDR016C_Skud2061.12.fasta YDR016C DAD1 2.6E+03 0 0 0.0YNL015W_Skud1496.2.fasta YNL015W PBI2 2.6E+03 0 0 0.0YDR280W_Skud1845.9.fasta YDR280W RRP45 2.6E+03 0.0146 0 3.3YKL043W_Skud2056.3.fasta YKL043W PHD1 2.6E+03 0.0163 0.0013 5.4YLR208W_Skud1821.7.fasta YLR208W SEC13 2.6E+03 0.0152 0.0033 4.2YER148W_Skud1636.4.fasta YER148W SPT15 2.6E+03 0.013 0 2.2YBR077C_Skud1661.2.fasta YBR077C SLM4 2.6E+03 0.0125 0.0032 2.1YDR434W_Skud1598.5.fasta YDR434W GPI17 2.6E+03 0.0166 0.0018 8.1YOR065W_Skud1854.2.fasta YOR065W CYT1 2.6E+03 0.0089 0 1.0YOR160W_Skud1740.2.fasta YOR160W MTR10 2.6E+03 0.0178 0.004 15.1YBR145W_Skud2051.14.fasta YBR145W ADH5 2.6E+03 0.0147 0.0024 3.3YKL135C_Skud1823.2.fasta YKL135C APL2 2.6E+03 0.0185 0.0047 11.9YMR004W_Skud2043.12.fasta YMR004W MVP1 2.6E+03 0.0163 0.0075 7.1YOR251C_Skud1958.11.fasta YOR251C TUM1 2.6E+03 0.0177 0.0101 4.9YLR260W_Skud1971.5.fasta YLR260W LCB5 2.6E+03 0.0175 0.0053 9.5YBR270C_Skud2064.4.fasta YBR270C BIT2 2.6E+03 0.0165 0.0062 8.1YGR215W_Skud1708.3.fasta YGR215W RSM27 2.6E+03 0 0 0.0YGL038C_Skud2052.15.fasta YGL038C OCH1 2.6E+03 0.0163 0.0059 6.3YDR247W_Skud1915.4.fasta YDR247W VHS1 2.6E+03 0.0167 0.0075 7.3YGL021W_Skud1875.2.fasta YGL021W ALK1 2.6E+03 0.017 0.0032 10.1YAL030W_Skud1086.2.fasta YAL030W SNC1 2.6E+03 0 0 0.0YPR020W_Skud1887.6.fasta YPR020W ATP20 2.6E+03 0.0162 0 1.8YOR386W_Skud1515.1.fasta YOR386W PHR1 2.6E+03 0.0172 0.0033 8.4YML110C_Skud1963.6.fasta YML110C COQ5 2.6E+03 0.0145 0.0032 4.0YML092C_Skud1304.2.fasta YML092C PRE8 2.6E+03 0.0176 0 4.0YIL154C_Skud1285.3.fasta YIL154C IMP2' 2.6E+03 0.0174 0.0012 3.0YDR148C_Skud1848.2.fasta YDR148C KGD2 2.6E+03 0.0164 0.0073 6.3YLR183C_Skud2032.8.fasta YLR183C TOS4 2.6E+03 0.0161 0.0064 6.2YGR101W_Skud1325.2.fasta YGR101W PCP1 2.6E+03 0.0153 0.0015 5.1YJR076C_Skud1916.10.fasta YJR076C CDC11 2.6E+03 0.0151 0.0021 4.2YGL144C_Skud1895.5.fasta YGL144C ROG1 2.6E+03 0.0173 0.0021 10.3YKL124W_Skud2020.2.fasta YKL124W SSH4 2.6E+03 0.0169 0.0016 7.4YBL081W_Skud952.2.fasta YBL081W 2.6E+03 0.016 0.0077 6.2YMR315W_Skud1561.2.fasta YMR315W 2.6E+03 0.018 0.0031 6.0YML041C_Skud1980.4.fasta YML041C VPS71 2.6E+03 0.0173 0.0017 3.9YMR134W_Skud1828.4.fasta YMR134W ERG29 2.6E+03 0.012 0.0018 2.1YPR106W_Skud1473.4.fasta YPR106W ISR1 2.6E+03 0.0158 0.0021 6.1YBL087C_Skud1758.3.fasta YBL087C RPL23A 2.6E+03 0.0088 0 1.0YKR074W_Skud2030.11.fasta YKR074W AIM29 2.6E+03 0.0172 0 2.9YPL145C_Skud1644.2.fasta YPL145C KES1 2.6E+03 0.0157 0.0011 6.1YGR112W_Skud1401.3.fasta YGR112W SHY1 2.6E+03 0.0151 0.0057 4.2YMR068W_Skud1522.3.fasta YMR068W AVO2 2.6E+03 0.015 0.0022 5.0YHR071W_Skud1817.5.fasta YHR071W PCL5 2.6E+03 0.0122 0.0062 2.1YDR110W_Skud1927.2.fasta YDR110W FOB1 2.6E+03 0.0163 0.0015 7.2YBR255W_Skud2064.19.fasta YBR255W MTC4 2.6E+03 0.017 0.004 9.3YNR049C_Skud693.1.fasta YNR049C MSO1 2.6E+03 0.0123 0.0087 2.1YJR134C_Skud1942.3.fasta YJR134C SGM1 2.6E+03 0.0182 0.0042 11.8YNL062C_Skud1596.2.fasta YNL062C GCD10 2.6E+03 0.0158 0.0056 6.1YGR058W_Skud2031.3.fasta YGR058W PEF1 2.6E+03 0.0143 0.0029 4.0YDL126C_Skud1786.5.fasta YDL126C CDC48 2.6E+03 0.0175 0 14.1YDR322C-A_Skud1175.2.fasta YDR322C-A TIM11 2.6E+03 0 0 0.0YHR185C_Skud2046.3.fasta YHR185C PFS1 2.6E+03 0.0002 0.0212 0.0YPR164W_Skud1949.4.fasta YPR164W MMS1 2.6E+03 0.0181 0.0047 21.0

YJL089W_Skud1640.1.fasta YJL089W SIP4 2.6E+03 0.0179 0.0063 14.4YDR354W_Skud1964.1.fasta YDR354W TRP4 2.6E+03 0.0152 0.0038 5.1YDR142C_Skud1410.3.fasta YDR142C PEX7 2.6E+03 0.015 0.0053 5.0YGR149W_Skud1690.5.fasta YGR149W 2.6E+03 0 0.003 0.0YDR260C_Skud2012.4.fasta YDR260C SWM1 2.6E+03 0.0092 0.0025 1.1YCL051W_Skud2065.6.fasta YCL051W LRE1 2.6E+03 0.0169 0.0039 7.5_Skud1899.4.fasta 2.6E+03 0.0167 0.0019 8.3YER087C-B_Skud1635.6.fasta YER087C-B SBH1 2.6E+03 0 0 0.0YBR187W_Skud1785.1.fasta YBR187W GDT1 2.6E+03 0.0148 0.0033 3.4YIL119C_Skud1925.6.fasta YIL119C RPI1 2.6E+03 0.0157 0.0026 6.1YGL018C_Skud1875.5.fasta YGL018C JAC1 2.6E+03 0.0086 0.0023 1.0YOR067C_Skud1854.4.fasta YOR067C ALG8 2.6E+03 0.0168 0 7.4YDR115W_Skud1927.5.fasta YDR115W 2.6E+03 0 0 0.0YMR035W_Skud941.1.fasta YMR035W IMP2 2.6E+03 0.0172 0 3.0YBL003C_Skud1586.2.fasta YBL003C HTA2 2.6E+03 0.0167 0 2.0YBR002C_Skud1395.4.fasta YBR002C RER2 2.6E+03 0.0132 0.0016 3.0YJL004C_Skud1686.2.fasta YJL004C SYS1 2.6E+03 0.0122 0.0038 2.1YDL203C_Skud1850.7.fasta YDL203C ACK1 2.6E+03 0.0171 0.0046 9.4YOR202W_Skud1616.2.fasta YOR202W HIS3 2.6E+03 0.0157 0.0053 5.3YGR081C_Skud1797.5.fasta YGR081C SLX9 2.6E+03 0.0116 0.0044 2.0YDR539W_Skud1570.2.fasta YDR539W 2.6E+03 0.0162 0.0009 6.3YDL121C_Skud1471.2.fasta YDL121C 2.6E+03 0.0165 0.0063 1.9YDR425W_Skud1634.5.fasta YDR425W SNX41 2.6E+03 0.0171 0.0056 10.3YMR310C_Skud1493.3.fasta YMR310C 2.6E+03 0.0143 0.0046 4.1YDR470C_Skud1959.8.fasta YDR470C UGO1 2.6E+03 0.0159 0.002 7.1YIL043C_Skud1799.7.fasta YIL043C CBR1 2.6E+03 0.0142 0 4.0YIL150C_Skud1588.2.fasta YIL150C MCM10 2.6E+03 0.0163 0.0048 7.2YOR141C_Skud1833.3.fasta YOR141C ARP8 2.6E+03 0.0176 0.0026 12.4YML127W_Skud1995.9.fasta YML127W RSC9 2.6E+03 0.0181 0.0029 10.9YGR165W_Skud1871.2.fasta YGR165W MRPS35 2.6E+03 0.0141 0.0095 4.0YBR184W_Skud1785.4.fasta YBR184W 2.7E+03 0.0165 0.011 7.3YDR411C_Skud1527.3.fasta YDR411C DFM1 2.7E+03 0.0154 0.0062 5.2YJL137C_Skud2041.5.fasta YJL137C GLG2 2.7E+03 0.0177 0.0056 6.9YBR014C_Skud1345.3.fasta YBR014C GRX7 2.7E+03 0.0115 0.0095 2.0YBR129C_Skud1937.4.fasta YBR129C OPY1 2.7E+03 0.0147 0.0027 4.2YNL196C_Skud1800.2.fasta YNL196C SLZ1 2.7E+03 0.0146 0.0048 4.2YGR227W_Skud1453.3.fasta YGR227W DIE2 2.7E+03 0.0171 0.0062 7.6YPR101W_Skud1693.3.fasta YPR101W SNT309 2.7E+03 0.0134 0.0049 3.1YBL074C_Skud1889.2.fasta YBL074C AAR2 2.7E+03 0.0159 0.0075 6.2YLR060W_Skud1414.2.fasta YLR060W FRS1 2.7E+03 0.0169 0.0047 8.4YOR038C_Skud2015.5.fasta YOR038C HIR2 2.7E+03 0.0173 0.0021 11.3YJL104W_Skud1954.7.fasta YJL104W PAM16 2.7E+03 0.0087 0 1.0YHR111W_Skud2024.8.fasta YHR111W UBA4 2.7E+03 0.0161 0.0078 7.2YJR121W_Skud1903.6.fasta YJR121W ATP2 2.7E+03 0.0161 0 8.0YGL091C_Skud1808.8.fasta YGL091C NBP35 2.7E+03 0.0142 0.0013 3.3YBR127C_Skud1937.2.fasta YBR127C VMA2 2.7E+03 0.0162 0 7.2YPL007C_Skud925.2.fasta YPL007C TFC8 2.7E+03 0.0164 0.004 8.2YPR103W_Skud1693.5.fasta YPR103W PRE2 2.7E+03 0.0134 0.0016 3.1YGR141W_Skud1517.2.fasta YGR141W VPS62 2.7E+03 0.0161 0.0056 5.5YDR303C_Skud1967.9.fasta YDR303C RSC3 2.7E+03 0.0171 0.0032 13.0YER128W_Skud1822.7.fasta YER128W 2.7E+03 0.0115 0.009 2.0YDR528W_Skud2001.7.fasta YDR528W HLR1 2.7E+03 0.0155 0.0035 6.1YKL065C_Skud1840.5.fasta YKL065C YET1 2.7E+03 0.0092 0 1.1

YFL038C_Skud1695.3.fasta YFL038C YPT1 2.7E+03 0.0166 0 2.9YLR149C_Skud1736.3.fasta YLR149C 2.7E+03 0.0165 0.0008 9.1YOL077W-A_Skud1718.4.fasta YOL077W-A ATP19 2.7E+03 0.0001 0.0084 0.0YER084W_Skud1635.2.fasta YER084W 2.7E+03 0.0089 0.0211 1.1YHR187W_Skud1553.2.fasta YHR187W IKI1 2.7E+03 0.0136 0.0103 3.2YML060W_Skud1531.2.fasta YML060W OGG1 2.7E+03 0.0141 0.0037 4.1YML053C_Skud1667.2.fasta YML053C 2.7E+03 0.0119 0.0079 2.1YNL211C_Skud1629.5.fasta YNL211C 2.7E+03 0 0 0.0YDR351W_Skud2047.11.fasta YDR351W SBE2 2.7E+03 0.0176 0.0055 13.4YNL094W_Skud1883.7.fasta YNL094W APP1 2.7E+03 0.0147 0.0039 4.2YNL021W_Skud1892.6.fasta YNL021W HDA1 2.7E+03 0.017 0.0007 11.2YAR007C_Skud1902.6.fasta YAR007C RFA1 2.7E+03 0.0167 0.0008 9.3YEL056W_Skud1923.2.fasta YEL056W HAT2 2.7E+03 0.0153 0.0047 5.2YGR189C_Skud1129.1.fasta YGR189C CRH1 2.7E+03 0.0169 0.0084 9.4YER089C_Skud1340.1.fasta YER089C PTC2 2.7E+03 0.0154 0.001 6.1YJL065C_Skud1625.4.fasta YJL065C DLS1 2.7E+03 0.0117 0.0033 2.1YER137C_Skud1720.4.fasta YER137C 2.7E+03 0.0084 0.0063 1.0YLR438C-A_Skud243.1.fasta YLR438C-A LSM3 2.7E+03 0.0159 0 1.0YNL202W_Skud1680.3.fasta YNL202W SPS19 2.7E+03 0.0135 0.0032 3.2YNL178W_Skud1435.3.fasta YNL178W RPS3 2.7E+03 0.013 0.0021 3.0YDR538W_Skud1570.3.fasta YDR538W PAD1 2.7E+03 0.012 0.0037 2.1YBR249C_Skud2064.25.fasta YBR249C ARO4 2.7E+03 0.016 0.0012 7.2YDL076C_Skud2062.16.fasta YDL076C RXT3 2.7E+03 0.014 0.0017 4.0YDL194W_Skud1732.4.fasta YDL194W SNF3 2.7E+03 0.0177 0.0016 13.5YGR102C_Skud1325.3.fasta YGR102C 2.7E+03 0.0085 0.0024 1.0YMR112C_Skud1059.2.fasta YMR112C MED11 2.7E+03 0 0 0.0YGL064C_Skud1952.6.fasta YGL064C MRH4 2.7E+03 0.0163 0.0039 7.3YKL119C_Skud2020.6.fasta YKL119C VPH2 2.7E+03 0.0164 0.0067 2.9YDL230W_Skud1979.2.fasta YDL230W PTP1 2.7E+03 0.0147 0.0047 5.1YHR021C_Skud1621.2.fasta YHR021C RPS27B 2.7E+03 0 0 0.0YBL055C_Skud1907.9.fasta YBL055C 2.7E+03 0.0153 0.0036 6.1YKL170W_Skud1780.6.fasta YKL170W MRPL38 2.7E+03 0.0084 0 1.0YMR311C_Skud1493.4.fasta YMR311C GLC8 2.7E+03 0.013 0.0067 3.1YOR094W_Skud1647.2.fasta YOR094W ARF3 2.7E+03 0.0086 0.0024 1.0YDR292C_Skud2003.9.fasta YDR292C SRP101 2.7E+03 0.016 0.0029 7.2YLR405W_Skud2066.19.fasta YLR405W DUS4 2.7E+03 0.015 0.0024 5.2_Skud1901.7.fasta 2.7E+03 0.0132 0.0078 3.1YNL300W_Skud1872.5.fasta YNL300W TOS6 2.7E+03 0.0158 0 1.9YDR105C_Skud1239.2.fasta YDR105C TMS1 2.7E+03 0.0161 0.0032 7.3YBR162W-A_Skud1852.6.fasta YBR162W-A YSY6 2.7E+03 0.0155 0 0.9YMR244W_Skud1985.7.fasta YMR244W 2.7E+03 0.0149 0 5.1YJL214W_Skud1886.3.fasta YJL214W HXT8 2.7E+03 0.0152 0.0074 5.2YPR166C_Skud1949.6.fasta YPR166C MRP2 2.7E+03 0 0 0.0YLR423C_Skud1081.2.fasta YLR423C ATG17 2.7E+03 0.0148 0.0011 5.1YGR001C_Skud1881.8.fasta YGR001C AML1 2.7E+03 0.0132 0.0048 3.1YHR123W_Skud1988.5.fasta YHR123W EPT1 2.7E+03 0.0135 0.0013 3.2YOL142W_Skud1459.5.fasta YOL142W RRP40 2.7E+03 0.0117 0.0037 2.1YCR087C-A_Skud1764.6.fasta YCR087C-A LUG1 2.7E+03 0 0 0.0YNL129W_Skud1749.3.fasta YNL129W NRK1 2.7E+03 0.0168 0 4.0YLR180W_Skud2032.11.fasta YLR180W SAM1 2.7E+03 0.015 0 4.4YJL156C_Skud1272.2.fasta YJL156C SSY5 2.7E+03 0.0085 0.0059 1.0YBL005W_Skud1893.2.fasta YBL005W PDR3 2.7E+03 0.0175 0.0028 14.4_Skud1756.3.fasta 2.7E+03 0.0004 0.0351 0.0

YPL201C_Skud1659.4.fasta YPL201C YIG1 2.7E+03 0.0174 0.0084 7.0YDR529C_Skud2001.8.fasta YDR529C QCR7 2.7E+03 0.0159 0 2.0YGR289C_Skud1888.2.fasta YGR289C MAL11 2.7E+03 0.0164 0.0023 8.3YDR416W_Skud1447.2.fasta YDR416W SYF1 2.7E+03 0.0171 0.0043 11.4YDR259C_Skud2012.3.fasta YDR259C YAP6 2.7E+03 0.0151 0.0051 5.3YLL014W_Skud927.2.fasta YLL014W EMC6 2.7E+03 0.0081 0.0053 1.0_Skud334.2.fasta 2.7E+03 0 0 0.0YFR006W_Skud1792.5.fasta YFR006W 2.7E+03 0.0158 0.0056 8.0YDR288W_Skud1767.6.fasta YDR288W NSE3 2.7E+03 0.0138 0.0017 4.1YBR296C_Skud1849.3.fasta YBR296C PHO89 2.7E+03 0.0161 0.0017 8.2YPL253C_Skud302.8.fasta YPL253C VIK1 2.7E+03 0.0161 0.0034 8.2YLR390W_Skud2066.5.fasta YLR390W ECM19 2.7E+03 0.0001 0.008 0.0YML099C_Skud1950.6.fasta YML099C ARG81 2.7E+03 0.017 0.0027 13.1YLL012W_Skud1427.2.fasta YLL012W YEH1 2.7E+03 0.0176 0 9.0YKL178C_Skud1782.4.fasta YKL178C STE3 2.7E+03 0.0146 0.001 5.1YER048W-A_Skud2039.2.fasta YER048W-A ISD11 2.7E+03 0 0 0.0YER073W_Skud1843.6.fasta YER073W ALD5 2.7E+03 0.0157 0.0019 7.2YOR014W_Skud1656.4.fasta YOR014W RTS1 2.7E+03 0.0169 0.0018 9.5YHR048W_Skud1587.3.fasta YHR048W YHK8 2.8E+03 0.0166 0.0029 8.5YDR437W_Skud1598.2.fasta YDR437W GPI19 2.8E+03 0.0081 0 1.0YOR250C_Skud1958.10.fasta YOR250C CLP1 2.8E+03 0.0151 0.0044 6.1YER023W_Skud1593.4.fasta YER023W PRO3 2.8E+03 0.0137 0 4.0YDL047W_Skud1386.5.fasta YDL047W SIT4 2.8E+03 0.0117 0 2.1YGR147C_Skud1690.3.fasta YGR147C NAT2 2.8E+03 0.0167 0.0116 4.0YHL025W_Skud1842.2.fasta YHL025W SNF6 2.8E+03 0.0127 0.0055 3.0YGL247W_Skud1499.3.fasta YGL247W BRR6 2.8E+03 0.012 0.0103 2.2YKL122C_Skud2020.3.fasta YKL122C SRP21 2.8E+03 0.0159 0.0029 2.0YML015C_Skud951.3.fasta YML015C TAF11 2.8E+03 0.015 0.0016 6.1YGL079W_Skud2057.6.fasta YGL079W 2.8E+03 0.0113 0.0023 2.1YDR454C_Skud1543.3.fasta YDR454C GUK1 2.8E+03 0.011 0 2.0YGL189C_Skud1778.7.fasta YGL189C RPS26A 2.8E+03 0 0.0038 0.0YCL038C_Skud2072.7.fasta YCL038C ATG22 2.8E+03 0.016 0.002 8.2YNL253W_Skud1557.4.fasta YNL253W TEX1 2.8E+03 0.0145 0.0056 5.1YJL047C_Skud1771.4.fasta YJL047C RTT101 2.8E+03 0.017 0.0066 14.1YJL185C_Skud1825.9.fasta YJL185C 2.8E+03 0.0129 0.008 3.1YBR146W_Skud2051.13.fasta YBR146W MRPS9 2.8E+03 0.0113 0.0031 2.1YDR083W_Skud1929.4.fasta YDR083W RRP8 2.8E+03 0.0128 0.0022 3.1YDL226C_Skud1979.5.fasta YDL226C GCS1 2.8E+03 0.014 0.0013 4.1YDL004W_Skud1672.4.fasta YDL004W ATP16 2.8E+03 0.008 0 1.0YLR013W_Skud2025.12.fasta YLR013W GAT3 2.8E+03 0.0154 0 1.9YDL081C_Skud2062.11.fasta YDL081C RPP1A 2.8E+03 0.0082 0 1.0YOR195W_Skud1770.4.fasta YOR195W SLK19 2.8E+03 0.0165 0.0078 11.1YGR113W_Skud1401.2.fasta YGR113W DAM1 2.8E+03 0.0134 0.0051 3.2YBR253W_Skud2064.21.fasta YBR253W SRB6 2.8E+03 0.0087 0.0042 1.1YGL041C_Skud2052.18.fasta YGL041C 2.8E+03 0 0.0048 0.0_Skud1917.4.fasta 2.8E+03 0.0143 0.0051 5.0YML070W_Skud2021.6.fasta YML070W DAK1 2.8E+03 0.0163 0.0058 8.4YPR141C_Skud2053.12.fasta YPR141C KAR3 2.8E+03 0.0177 0.0045 11.0YLL034C_Skud1548.3.fasta YLL034C RIX7 2.8E+03 0.018 0.0006 14.0YBR053C_Skud1787.4.fasta YBR053C 2.8E+03 0.0132 0 3.2YLR307W_Skud1779.3.fasta YLR307W CDA1 2.8E+03 0.0121 0.0042 2.2YOR258W_Skud1774.2.fasta YOR258W HNT3 2.8E+03 0.0165 0.0074 4.0YDL214C_Skud1815.2.fasta YDL214C PRR2 2.8E+03 0.0167 0.005 11.2

YOR159C_Skud1740.3.fasta YOR159C SME1 2.8E+03 0 0 0.0YDR527W_Skud2001.6.fasta YDR527W RBA50 2.8E+03 0.0149 0.0032 5.3YMR110C_Skud1318.2.fasta YMR110C HFD1 2.8E+03 0.0158 0.0018 7.3YNL071W_Skud1657.3.fasta YNL071W LAT1 2.8E+03 0.0155 0.0021 7.1YGR038W_Skud1926.7.fasta YGR038W ORM1 2.8E+03 0.0161 0 3.0YBR176W_Skud1973.4.fasta YBR176W ECM31 2.8E+03 0.0133 0 3.2YHL002W_Skud2034.14.fasta YHL002W HSE1 2.8E+03 0.0155 0.0092 7.2YCL050C_Skud2065.5.fasta YCL050C APA1 2.8E+03 0.0138 0.0055 3.3YJL012C_Skud1835.10.fasta YJL012C VTC4 2.8E+03 0.0176 0 10.9YJL012C-A_Skud1835.9.fasta YJL012C-A 2.8E+03 0.0176 0 10.9YML058W_Skud1726.3.fasta YML058W SML1 2.8E+03 0 0 0.0YLR186W_Skud2032.6.fasta YLR186W EMG1 2.8E+03 0.0161 0.002 3.9YOR335C_Skud2005.4.fasta YOR335C ALA1 2.8E+03 0.0174 0 15.4YOL039W_Skud1723.4.fasta YOL039W RPP2A 2.8E+03 0.0083 0 1.1YNL287W_Skud1837.2.fasta YNL287W SEC21 2.8E+03 0.0168 0 13.1YGL103W_Skud1658.3.fasta YGL103W RPL28 2.8E+03 0 0 0.0YLR288C_Skud2059.13.fasta YLR288C MEC3 2.8E+03 0.0156 0.0011 7.2YBR195C_Skud1989.5.fasta YBR195C MSI1 2.8E+03 0.0147 0.0033 5.2YER125W_Skud1822.4.fasta YER125W RSP5 2.8E+03 0.0168 0.0018 12.2YPR160W_Skud1870.2.fasta YPR160W GPH1 2.8E+03 0.0171 0.0005 11.6YDR363W_Skud1964.8.fasta YDR363W ESC2 2.8E+03 0.0139 0.0019 4.2YJR036C_Skud1706.1.fasta YJR036C HUL4 2.8E+03 0.0179 0.0059 14.0YHL013C_Skud2034.4.fasta YHL013C OTU2 2.8E+03 0.0128 0.0044 3.1YDR062W_Skud1900.3.fasta YDR062W LCB2 2.8E+03 0.0147 0.0008 6.0YJL139C_Skud2041.7.fasta YJL139C YUR1 2.8E+03 0.0148 0.0059 6.1YGL183C_Skud1778.2.fasta YGL183C MND1 2.8E+03 0.0107 0.0091 2.0YDR251W_Skud1915.7.fasta YDR251W PAM1 2.8E+03 0.0166 0.0017 12.1YDR436W_Skud1598.3.fasta YDR436W PPZ2 2.8E+03 0.0162 0.0032 9.3YLR210W_Skud1821.5.fasta YLR210W CLB4 2.8E+03 0.0153 0.0021 6.3YJR042W_Skud1342.2.fasta YJR042W NUP85 2.8E+03 0.0165 0.0032 10.3YEL037C_Skud1692.4.fasta YEL037C RAD23 2.8E+03 0.0151 0.0025 5.4YCL044C_Skud2072.2.fasta YCL044C MGR1 2.8E+03 0.0126 0.0017 3.1YMR121C_Skud1684.5.fasta YMR121C RPL15B 2.8E+03 0.011 0.0027 2.1_Skud1845.7.fasta 2.8E+03 0.0124 0.0187 3.0YPR034W_Skud1603.3.fasta YPR034W ARP7 2.8E+03 0.0144 0.0019 5.1YPL106C_Skud1710.6.fasta YPL106C SSE1 2.8E+03 0.0167 0 10.5YMR150C_Skud1956.12.fasta YMR150C IMP1 2.8E+03 0.0111 0 2.1YDR002W_Skud1100.1.fasta YDR002W YRB1 2.8E+03 0.0123 0.0022 3.0YJL081C_Skud1768.4.fasta YJL081C ARP4 2.8E+03 0.0147 0.0018 5.2YCL064C_Skud2065.17.fasta YCL064C CHA1 2.8E+03 0.0129 0.0012 3.2YOR012W_Skud1656.2.fasta YOR012W 2.8E+03 0.0084 0.0024 1.1YDR499W_Skud1891.7.fasta YDR499W LCD1 2.8E+03 0.0166 0.0029 8.7YMR043W_Skud779.2.fasta YMR043W MCM1 2.8E+03 0.0159 0.0019 3.9YNR019W_Skud1660.4.fasta YNR019W ARE2 2.8E+03 0.0162 0.0031 9.3YDR394W_Skud1446.2.fasta YDR394W RPT3 2.8E+03 0.0145 0 5.2YKL042W_Skud2056.2.fasta YKL042W SPC42 2.8E+03 0.0143 0.0082 5.1YJR001W_Skud1686.6.fasta YJR001W AVT1 2.8E+03 0.016 0.0016 8.3YJR124C_Skud1903.3.fasta YJR124C 2.8E+03 0.0155 0.002 6.4YOL117W_Skud1896.10.fasta YOL117W RRI2 2.8E+03 0.016 0.0043 8.3YMR309C_Skud1493.2.fasta YMR309C NIP1 2.8E+03 0.0165 0.0005 9.5YOR131C_Skud1941.9.fasta YOR131C 2.8E+03 0.0113 0.0043 2.1YBR074W_Skud1661.5.fasta YBR074W 2.8E+03 0.0169 0.001 15.1YBR075W_Skud1661.4.fasta YBR075W 2.8E+03 0.0169 0.001 15.1

YLR401C_Skud2066.15.fasta YLR401C DUS3 2.8E+03 0.016 0.002 8.4YGL186C_Skud1778.5.fasta YGL186C TPN1 2.8E+03 0.0158 0.0017 8.3YHR013C_Skud2067.8.fasta YHR013C ARD1 2.8E+03 0.0124 0.0022 3.1YPL063W_Skud1974.5.fasta YPL063W TIM50 2.8E+03 0.017 0.0032 8.0YNL081C_Skud1628.6.fasta YNL081C SWS2 2.8E+03 0.015 0 2.0YLR195C_Skud1827.5.fasta YLR195C NMT1 2.8E+03 0.0138 0.0027 3.4YBR261C_Skud2064.12.fasta YBR261C TAE1 2.8E+03 0.0124 0 3.1YGR110W_Skud1571.3.fasta YGR110W CLD1 2.8E+03 0.0167 0.0065 6.9YOR027W_Skud1983.4.fasta YOR027W STI1 2.8E+03 0.0162 0.0017 9.3YGR075C_Skud1944.2.fasta YGR075C PRP38 2.8E+03 0.0106 0.0119 2.0YLR114C_Skud2004.9.fasta YLR114C AVL9 2.8E+03 0.0158 0.0024 7.4YML085C_Skud1117.2.fasta YML085C TUB1 2.9E+03 0.0122 0 3.0YFL013C_Skud1910.7.fasta YFL013C IES1 2.9E+03 0.0158 0.0026 8.3YJL118W_Skud1091.2.fasta YJL118W 2.9E+03 0.0141 0.0127 4.3_Skud1091.3.fasta 2.9E+03 0.0141 0.0127 4.3YPL203W_Skud1659.2.fasta YPL203W TPK2 2.9E+03 0.0126 0 3.1YDR248C_Skud1915.5.fasta YDR248C 2.9E+03 0.0155 0.0026 3.0YPL020C_Skud1501.3.fasta YPL020C ULP1 2.9E+03 0.0146 0.0019 4.5YLL009C_Skud1676.4.fasta YLL009C COX17 2.9E+03 0.0142 0.0072 1.0YDR387C_Skud1156.2.fasta YDR387C 2.9E+03 0.0156 0.0017 7.3YCR008W_Skud1966.3.fasta YCR008W SAT4 2.9E+03 0.0157 0.0021 6.5YAL056W_Skud1874.4.fasta YAL056W GPB2 2.9E+03 0.0122 0.0056 3.0YLR404W_Skud2066.18.fasta YLR404W FLD1 2.9E+03 0.0124 0.0017 3.1YJL177W_Skud1825.2.fasta YJL177W RPL17B 2.9E+03 0 0 0.0YNL295W_Skud1783.2.fasta YNL295W 2.9E+03 0.0143 0.0019 5.2YOR289W_Skud1737.2.fasta YOR289W 2.9E+03 0.0108 0.0058 2.1YPR186C_Skud1529.3.fasta YPR186C PZF1 2.9E+03 0.0131 0.0011 4.0YJL036W_Skud1920.2.fasta YJL036W SNX4 2.9E+03 0.0139 0.0022 5.0YBR165W_Skud1852.9.fasta YBR165W UBS1 2.9E+03 0.0125 0.0035 3.1YGR238C_Skud1935.3.fasta YGR238C KEL2 2.9E+03 0.0166 0.0081 12.3YMR208W_Skud1242.2.fasta YMR208W ERG12 2.9E+03 0.0166 0.0034 6.9YJR102C_Skud1794.5.fasta YJR102C VPS25 2.9E+03 0.0109 0.0025 2.1YML113W_Skud1963.3.fasta YML113W DAT1 2.9E+03 0.0085 0.0017 1.1YDL014W_Skud1867.2.fasta YDL014W NOP1 2.9E+03 0.0132 0 4.1YGL081W_Skud2057.4.fasta YGL081W 2.9E+03 0.012 0.0029 3.0YPL120W_Skud1951.8.fasta YPL120W VPS30 2.9E+03 0.0161 0.0056 7.6YKL160W_Skud1554.2.fasta YKL160W ELF1 2.9E+03 0.015 0.0068 2.0YBR029C_Skud2061.6.fasta YBR029C CDS1 2.9E+03 0.0144 0.0011 6.0YLR276C_Skud1933.5.fasta YLR276C DBP9 2.9E+03 0.0164 0 7.8YHR191C_Skud1553.6.fasta YHR191C CTF8 2.9E+03 0.0076 0 1.0YHR031C_Skud1508.2.fasta YHR031C RRM3 2.9E+03 0.0158 0.0013 9.2YKL211C_Skud1202.2.fasta YKL211C TRP3 2.9E+03 0.0146 0.002 6.1YOL128C_Skud2006.8.fasta YOL128C YGK3 2.9E+03 0.0136 0.0037 4.2YGL080W_Skud2057.5.fasta YGL080W FMP37 2.9E+03 0.0076 0 1.0YMR223W_Skud1336.2.fasta YMR223W UBP8 2.9E+03 0.0152 0.0011 7.2YDL212W_Skud1437.2.fasta YDL212W SHR3 2.9E+03 0.0075 0.0044 1.0YDR459C_Skud1572.3.fasta YDR459C PFA5 2.9E+03 0.0144 0.0039 5.2YDR380W_Skud1468.2.fasta YDR380W ARO10 2.9E+03 0.016 0.0052 8.5YPL029W_Skud1112.1.fasta YPL029W SUV3 2.9E+03 0.0162 0.0032 10.3YLL046C_Skud1355.3.fasta YLL046C RNP1 2.9E+03 0.0156 0.0122 3.9YPR168W_Skud1949.8.fasta YPR168W NUT2 2.9E+03 0.0077 0.0061 1.0YBR008C_Skud2013.8.fasta YBR008C FLR1 2.9E+03 0.015 0.0093 6.3YGL228W_Skud1511.5.fasta YGL228W SHE10 2.9E+03 0.0152 0.0033 7.2

YNL244C_Skud1216.2.fasta YNL244C SUI1 2.9E+03 0 0 0.0YHR113W_Skud2024.6.fasta YHR113W 2.9E+03 0.0168 0.0052 8.0YGR214W_Skud1708.4.fasta YGR214W RPS0A 2.9E+03 0 0 0.0YCR095C_Skud2040.10.fasta YCR095C OCA4 2.9E+03 0.012 0.0037 3.0YDL070W_Skud1991.11.fasta YDL070W BDF2 2.9E+03 0.0156 0.0038 9.1YKL059C_Skud2056.18.fasta YKL059C MPE1 2.9E+03 0.0104 0 2.0YOR344C_Skud1945.3.fasta YOR344C TYE7 2.9E+03 0.0131 0.0018 4.1YKL056C_Skud2056.15.fasta YKL056C TMA19 2.9E+03 0.0107 0 2.1YJL134W_Skud2041.3.fasta YJL134W LCB3 2.9E+03 0.0137 0.0012 5.0YGR203W_Skud723.2.fasta YGR203W 2.9E+03 0.0142 0 1.9YOL040C_Skud1723.5.fasta YOL040C RPS15 2.9E+03 0.0077 0 1.0YDL055C_Skud1312.2.fasta YDL055C PSA1 2.9E+03 0.0137 0 5.0YKL167C_Skud1780.4.fasta YKL167C MRP49 2.9E+03 0 0.0029 0.0YJR150C_Skud1645.2.fasta YJR150C DAN1 2.9E+03 0.013 0.0018 4.0YDL179W_Skud2045.7.fasta YDL179W PCL9 2.9E+03 0.016 0.0068 5.0YMR077C_Skud1524.4.fasta YMR077C VPS20 2.9E+03 0.0112 0.006 2.2YDR208W_Skud1549.2.fasta YDR208W MSS4 2.9E+03 0.016 0.0031 10.2YMR286W_Skud1713.2.fasta YMR286W MRPL33 2.9E+03 0.0002 0.0199 0.0YGL061C_Skud1952.3.fasta YGL061C DUO1 2.9E+03 0.0156 0.0021 4.0YKR083C_Skud880.1.fasta YKR083C DAD2 2.9E+03 0.0076 0.004 1.0YKL138C_Skud1823.4.fasta YKL138C MRPL31 2.9E+03 0.0139 0.0041 1.9YDR196C_Skud1918.9.fasta YDR196C CAB5 2.9E+03 0.0105 0.0039 2.1YDR249C_Skud1915.6.fasta YDR249C 2.9E+03 0.0135 0.0062 4.2YKL073W_Skud1361.2.fasta YKL073W LHS1 2.9E+03 0.0162 0.0031 11.2YEL050C_Skud1931.9.fasta YEL050C RML2 2.9E+03 0.013 0.0023 4.1YFR007W_Skud1792.3.fasta YFR007W YFH7 2.9E+03 0.0129 0.0041 4.0YER064C_Skud1762.5.fasta YER064C 2.9E+03 0.0146 0.0085 6.2YGR028W_Skud1715.3.fasta YGR028W MSP1 2.9E+03 0.0134 0.0045 4.2YML020W_Skud2017.8.fasta YML020W 2.9E+03 0.0157 0.0043 9.2YNL227C_Skud1866.5.fasta YNL227C JJJ1 2.9E+03 0.0146 0.0044 6.2YLR290C_Skud2059.11.fasta YLR290C 2.9E+03 0.0106 0.0016 2.1YOR275C_Skud1682.2.fasta YOR275C RIM20 2.9E+03 0.0171 0.0045 11.0YOR145C_Skud1833.8.fasta YOR145C PNO1 2.9E+03 0.0155 0.0018 4.0YER153C_Skud2047.2.fasta YER153C PET122 2.9E+03 0.015 0.0057 3.0YCL021W-A_Skud2072.22.fasta YCL021W-A 2.9E+03 0.0142 0.0088 1.9YBL092W_Skud1495.4.fasta YBL092W RPL32 2.9E+03 0.0073 0 1.0YNL139C_Skud1855.5.fasta YNL139C THO2 2.9E+03 0.0175 0.004 21.4YDL176W_Skud2045.5.fasta YDL176W 2.9E+03 0.0159 0.0018 7.6YNL099C_Skud1906.4.fasta YNL099C OCA1 2.9E+03 0.0104 0.0037 2.1YOL077C_Skud1718.3.fasta YOL077C BRX1 2.9E+03 0.0104 0 2.1YNR036C_Skud1741.5.fasta YNR036C MRPS12 2.9E+03 0.0142 0 1.9YIR032C_Skud1206.2.fasta YIR032C DAL3 2.9E+03 0.0151 0 3.0YBR147W_Skud2051.12.fasta YBR147W RTC2 2.9E+03 0.0122 0.003 3.1YNL254C_Skud1557.3.fasta YNL254C RTC4 2.9E+03 0.0135 0.0074 5.0YJR067C_Skud1916.2.fasta YJR067C YAE1 2.9E+03 0.0075 0.0144 1.0YGL126W_Skud1717.3.fasta YGL126W SCS3 2.9E+03 0.0121 0.0047 3.1YKL024C_Skud1981.4.fasta YKL024C URA6 2.9E+03 0.0079 0.0021 1.1YCR066W_Skud1668.3.fasta YCR066W RAD18 2.9E+03 0.0146 0.0062 7.0YBR264C_Skud2064.9.fasta YBR264C YPT10 2.9E+03 0.0102 0.0051 2.0YFR005C_Skud1792.6.fasta YFR005C SAD1 2.9E+03 0.0161 0.0049 7.8YJR096W_Skud1662.3.fasta YJR096W 2.9E+03 0.0117 0.0035 3.0YLR189C_Skud2032.3.fasta YLR189C ATG26 2.9E+03 0.0173 0.0034 15.8YBL033C_Skud2007.12.fasta YBL033C RIB1 2.9E+03 0.0117 0.0013 3.0

_Skud1889.3.fasta 2.9E+03 0.0002 0.0162 0.0YGR285C_Skud1618.3.fasta YGR285C ZUO1 2.9E+03 0.0143 0.0024 6.1YGL157W_Skud2042.8.fasta YGL157W 2.9E+03 0.0128 0.0025 3.3YDL146W_Skud1602.3.fasta YDL146W LDB17 3.0E+03 0.0141 0.0037 5.2YBR272C_Skud2064.2.fasta YBR272C HSM3 3.0E+03 0.0158 0.0073 6.8YCR036W_Skud2035.9.fasta YCR036W RBK1 3.0E+03 0.0121 0.0014 3.1YMR225C_Skud746.1.fasta YMR225C MRPL44 3.0E+03 0.0001 0.0086 0.0YPR140W_Skud2053.11.fasta YPR140W TAZ1 3.0E+03 0.0135 0.0026 5.0YIR007W_Skud1884.5.fasta YIR007W 3.0E+03 0.0162 0.0043 10.5YKR027W_Skud1613.4.fasta YKR027W BCH2 3.0E+03 0.0157 0.005 10.2YHR200W_Skud1913.8.fasta YHR200W RPN10 3.0E+03 0.0104 0.007 2.1YAL058W_Skud1874.3.fasta YAL058W CNE1 3.0E+03 0.0145 0.0066 6.2YJR073C_Skud1916.7.fasta YJR073C OPI3 3.0E+03 0.0106 0 2.1YEL012W_Skud1338.3.fasta YEL012W UBC8 3.0E+03 0.0117 0.0021 3.0YMR237W_Skud1773.2.fasta YMR237W BCH1 3.0E+03 0.0159 0.0007 12.0YDR277C_Skud1845.6.fasta YDR277C MTH1 3.0E+03 0.0139 0.0033 5.2YDR330W_Skud1638.4.fasta YDR330W UBX5 3.0E+03 0.0148 0.0072 7.2YPL098C_Skud2058.3.fasta YPL098C MGR2 3.0E+03 0 0 0.0YHL038C_Skud1947.6.fasta YHL038C CBP2 3.0E+03 0.0169 0.005 11.0YIL127C_Skud2022.3.fasta YIL127C RRT14 3.0E+03 0.0139 0.0064 1.9YEL024W_Skud1858.2.fasta YEL024W RIP1 3.0E+03 0.0083 0 1.2YJR137C_Skud1942.7.fasta YJR137C ECM17 3.0E+03 0.0178 0.0017 21.9YPL049C_Skud1641.5.fasta YPL049C DIG1 3.0E+03 0.0142 0.0096 5.3YDR397C_Skud1573.5.fasta YDR397C NCB2 3.0E+03 0.0073 0 1.0YDR517W_Skud1594.4.fasta YDR517W GRH1 3.0E+03 0.0136 0.0029 5.1YPL086C_Skud2058.16.fasta YPL086C ELP3 3.0E+03 0.0161 0.0009 7.8YOR382W_Skud2036.4.fasta YOR382W FIT2 3.0E+03 0.0074 0.0032 1.0YKL185W_Skud1844.2.fasta YKL185W ASH1 3.0E+03 0.0153 0.0024 8.3YER018C_Skud1655.6.fasta YER018C SPC25 3.0E+03 0.0115 0 3.0YOR166C_Skud2050.12.fasta YOR166C SWT1 3.0E+03 0.0125 0.0054 3.3YHR169W_Skud1709.4.fasta YHR169W DBP8 3.0E+03 0.0118 0.0016 3.1YER150W_Skud1636.2.fasta YER150W SPI1 3.0E+03 0.0074 0.0039 1.0YCL066W_Skud1781.4.fasta YCL066W HMLALPHA1 3.0E+03 0 0.003 0.0YPL226W_Skud1934.6.fasta YPL226W NEW1 3.0E+03 0.0168 0.0004 15.5YGL127C_Skud1717.4.fasta YGL127C SOH1 3.0E+03 0 0 0.0YGL111W_Skud2026.3.fasta YGL111W NSA1 3.0E+03 0.0161 0.0076 7.0YLR019W_Skud2025.6.fasta YLR019W PSR2 3.0E+03 0.0133 0.0065 5.0YBR235W_Skud1458.5.fasta YBR235W 3.0E+03 0 0 0.0YOR187W_Skud1997.5.fasta YOR187W TUF1 3.0E+03 0.0141 0.0011 5.3YPR169W_Skud1949.9.fasta YPR169W JIP5 3.0E+03 0.0134 0.0009 5.1YOR081C_Skud1829.3.fasta YOR081C TGL5 3.0E+03 0.0155 0.0019 9.3YHR167W_Skud1584.3.fasta YHR167W THP2 3.0E+03 0.012 0.0095 3.2YDR298C_Skud2003.3.fasta YDR298C ATP5 3.0E+03 0.0141 0 2.9YGL187C_Skud1778.6.fasta YGL187C COX4 3.0E+03 0.0139 0 2.0YDL154W_Skud1673.2.fasta YDL154W MSH5 3.0E+03 0.0163 0.0035 11.5YGL142C_Skud1895.7.fasta YGL142C GPI10 3.0E+03 0.0155 0.0041 9.3YML017W_Skud2017.11.fasta YML017W PSP2 3.0E+03 0.0141 0.0032 6.1YDL042C_Skud1681.4.fasta YDL042C SIR2 3.0E+03 0.0144 0.0024 6.2YPL112C_Skud1951.1.fasta YPL112C PEX25 3.0E+03 0.015 0.0026 5.7YDL036C_Skud1357.2.fasta YDL036C PUS9 3.0E+03 0.013 0.0057 4.2YNL162W-A_Skud1700.5.fasta YNL162W-A 3.0E+03 0.013 0.0074 1.0_Skud1899.7.fasta 3.0E+03 0 0.0039 0.0YHL022C_Skud1842.5.fasta YHL022C SPO11 3.0E+03 0.0154 0.004 5.8

YKL100C_Skud2010.2.fasta YKL100C 3.0E+03 0.0103 0.0029 2.1YCR063W_Skud2008.9.fasta YCR063W BUD31 3.0E+03 0 0 0.0YJR118C_Skud1903.9.fasta YJR118C ILM1 3.0E+03 0.0141 0.0028 2.9YOR058C_Skud1846.3.fasta YOR058C ASE1 3.0E+03 0.0161 0.0047 11.4_Skud1989.1.fasta 3.0E+03 0.0139 0 2.0YOR369C_Skud2013.3.fasta YOR369C RPS12 3.0E+03 0.0072 0.0036 1.0YNL224C_Skud1866.7.fasta YNL224C SQS1 3.0E+03 0.0153 0.0042 9.2YFR041C_Skud1262.2.fasta YFR041C ERJ5 3.0E+03 0.0147 0.0034 3.9YKR069W_Skud2030.6.fasta YKR069W MET1 3.0E+03 0.0147 0.0008 7.2YDL112W_Skud1382.1.fasta YDL112W TRM3 3.0E+03 0.017 0.0071 21.1YLR250W_Skud1857.3.fasta YLR250W SSP120 3.0E+03 0.0101 0.004 2.1YMR087W_Skud1803.6.fasta YMR087W 3.0E+03 0.0123 0.0017 3.3YMR265C_Skud2070.18.fasta YMR265C 3.0E+03 0.0134 0.0071 5.1YEL022W_Skud1858.4.fasta YEL022W GEA2 3.0E+03 0.0174 0.0014 23.5YNL328C_Skud1653.2.fasta YNL328C MDJ2 3.0E+03 0 0 0.0YPR030W_Skud1841.2.fasta YPR030W CSR2 3.0E+03 0.0168 0.0029 15.6YOL007C_Skud1977.11.fasta YOL007C CSI2 3.0E+03 0.0117 0.0107 3.1YMR127C_Skud2044.12.fasta YMR127C SAS2 3.0E+03 0.0115 0.004 3.1YBR055C_Skud1787.2.fasta YBR055C PRP6 3.0E+03 0.017 0.0061 13.9YER115C_Skud1856.3.fasta YER115C SPR6 3.0E+03 0.0073 0.007 1.1YCR084C_Skud1764.4.fasta YCR084C TUP1 3.0E+03 0.0154 0.0014 10.1YLR265C_Skud1547.2.fasta YLR265C NEJ1 3.0E+03 0.0143 0.0087 3.0YOR301W_Skud1580.3.fasta YOR301W RAX1 3.0E+03 0.0139 0.002 6.1YBR267W_Skud2064.7.fasta YBR267W REI1 3.0E+03 0.0155 0.0052 5.9YMR041C_Skud1486.2.fasta YMR041C ARA2 3.0E+03 0.0115 0.0051 3.1YLR059C_Skud1414.3.fasta YLR059C REX2 3.0E+03 0.0102 0.0017 2.1YER174C_Skud1863.3.fasta YER174C GRX4 3.0E+03 0.008 0 1.2YPL252C_Skud302.9.fasta YPL252C YAH1 3.0E+03 0.007 0.0028 1.0YKL128C_Skud1719.2.fasta YKL128C PMU1 3.0E+03 0.0117 0.0049 3.1YGL120C_Skud2026.12.fasta YGL120C PRP43 3.0E+03 0.0169 0 13.0YNL046W_Skud1809.7.fasta YNL046W 3.0E+03 0.007 0.0108 1.0YGR163W_Skud1871.3.fasta YGR163W GTR2 3.0E+03 0.0107 0 2.2YLR182W_Skud2032.9.fasta YLR182W SWI6 3.0E+03 0.0155 0.0029 10.2YLR418C_Skud1928.8.fasta YLR418C CDC73 3.0E+03 0.0126 0.0083 4.1YLR110C_Skud2004.5.fasta YLR110C CCW12 3.0E+03 0.0132 0 1.9YOR227W_Skud1729.6.fasta YOR227W HER1 3.0E+03 0.0169 0.0042 17.5YFR010W_Skud1385.2.fasta YFR010W UBP6 3.0E+03 0.0139 0.0019 6.1YJL068C_Skud1625.6.fasta YJL068C 3.0E+03 0.0123 0.0036 4.0YHR203C_Skud1913.5.fasta YHR203C RPS4B 3.0E+03 0 0 0.0YMR201C_Skud1878.6.fasta YMR201C RAD14 3.0E+03 0.0098 0.0014 2.0YMR222C_Skud1336.1.fasta YMR222C FSH2 3.0E+03 0.0078 0 1.1_Skud2030.10.fasta 3.0E+03 0.0001 0.0075 0.0YLR042C_Skud1946.8.fasta YLR042C 3.0E+03 0.0099 0.0084 1.4YBR121C_Skud1759.5.fasta YBR121C GRS1 3.0E+03 0.015 0.0007 8.3YMR238W_Skud1773.1.fasta YMR238W DFG5 3.0E+03 0.0121 0.0027 3.2YIL023C_Skud1791.2.fasta YIL023C YKE4 3.0E+03 0.0115 0.0082 3.1YFL052W_Skud1886.1.fasta YFL052W 3.0E+03 0.0128 0.0029 4.2YLR450W_Skud1639.4.fasta YLR450W HMG2 3.0E+03 0.0164 0.0028 14.4YOL093W_Skud1742.5.fasta YOL093W TRM10 3.0E+03 0.0112 0.005 3.0YIL064W_Skud1784.6.fasta YIL064W SEE1 3.0E+03 0.0142 0.009 3.0YHR007C_Skud2067.14.fasta YHR007C ERG11 3.0E+03 0.0143 0 6.3YHL006C_Skud2034.11.fasta YHL006C SHU1 3.0E+03 0.007 0.0028 1.0YMR302C_Skud1351.3.fasta YMR302C YME2 3.0E+03 0.0154 0.0006 11.0

YGL006W_Skud1881.2.fasta YGL006W PMC1 3.0E+03 0.017 0.0023 15.9YPR027C_Skud1841.5.fasta YPR027C 3.0E+03 0.0125 0.0047 4.1YGR268C_Skud382.1.fasta YGR268C HUA1 3.0E+03 0.0097 0.0027 2.0YJL166W_Skud1754.3.fasta YJL166W QCR8 3.0E+03 0.0125 0 1.0YOL073C_Skud1443.2.fasta YOL073C 3.0E+03 0.0151 0.0147 4.9YMR060C_Skud1449.3.fasta YMR060C SAM37 3.0E+03 0.0146 0.0049 4.8YMR081C_Skud1917.2.fasta YMR081C ISF1 3.0E+03 0.0113 0.0053 3.0YLR329W_Skud2002.5.fasta YLR329W REC102 3.0E+03 0.0071 0.0022 1.0YMR295C_Skud1793.7.fasta YMR295C IBI2 3.0E+03 0.01 0 2.1YDL027C_Skud1646.2.fasta YDL027C 3.1E+03 0.0132 0.0049 5.1YIL015W_Skud1960.5.fasta YIL015W BAR1 3.1E+03 0.014 0.0019 6.2YEL047C_Skud1931.6.fasta YEL047C 3.1E+03 0.0132 0.0028 4.3YLR170C_Skud2071.9.fasta YLR170C APS1 3.1E+03 0 0 0.0YDR281C_Skud1845.10.fasta YDR281C PHM6 3.1E+03 0.0001 0.0116 0.0YKL091C_Skud1457.3.fasta YKL091C 3.1E+03 0.0151 0.007 5.0YBR120C_Skud1759.4.fasta YBR120C CBP6 3.1E+03 0.0068 0 1.0YML046W_Skud1980.7.fasta YML046W PRP39 3.1E+03 0.014 0.0056 6.2YPL103C_Skud1429.1.fasta YPL103C FMP30 3.1E+03 0.0139 0.0021 6.2YOR129C_Skud1941.7.fasta YOR129C AFI1 3.1E+03 0.0161 0.0063 12.5YBR186W_Skud1785.2.fasta YBR186W PCH2 3.1E+03 0.0127 0.0032 1.9YGL010W_Skud1261.3.fasta YGL010W 3.1E+03 0.014 0.0066 3.0YER090W_Skud1340.2.fasta YER090W TRP2 3.1E+03 0.0136 0.0027 5.3YKL175W_Skud1782.6.fasta YKL175W ZRT3 3.1E+03 0.0135 0.0041 5.2YHR109W_Skud2024.10.fasta YHR109W CTM1 3.1E+03 0.0147 0.0082 7.4YKL173W_Skud1264.2.fasta YKL173W SNU114 3.1E+03 0.016 0.0063 14.1YDL183C_Skud2045.11.fasta YDL183C 3.1E+03 0.0147 0.0044 4.0YKL003C_Skud1788.7.fasta YKL003C MRP17 3.1E+03 0 0 0.0YBL020W_Skud1707.4.fasta YBL020W RFT1 3.1E+03 0.0138 0.0016 6.1YKL113C_Skud2020.10.fasta YKL113C RAD27 3.1E+03 0.0122 0.0063 4.0YNL237W_Skud1688.4.fasta YNL237W YTP1 3.1E+03 0.0136 0.0021 5.3YHL011C_Skud2034.6.fasta YHL011C PRS3 3.1E+03 0.0104 0 2.2YGL145W_Skud1895.4.fasta YGL145W TIP20 3.1E+03 0.016 0.0042 9.8YBR200W_Skud1989.10.fasta YBR200W BEM1 3.1E+03 0.0137 0.0017 6.1YGL116W_Skud2026.8.fasta YGL116W CDC20 3.1E+03 0.0145 0.0015 7.3YJL138C_Skud2041.6.fasta YJL138C TIF2 3.1E+03 0.0129 0 5.0YPL219W_Skud1305.2.fasta YPL219W PCL8 3.1E+03 0.013 0.0035 4.3YHR064C_Skud1807.2.fasta YHR064C SSZ1 3.1E+03 0.0143 0.0018 7.2YER081W_Skud1738.5.fasta YER081W SER3 3.1E+03 0.013 0.0019 4.3YOL087C_Skud1391.3.fasta YOL087C DUF1 3.1E+03 0.0163 0.0046 14.4YCR086W_Skud1764.5.fasta YCR086W CSM1 3.1E+03 0 0 0.0YKL144C_Skud1111.2.fasta YKL144C RPC25 3.1E+03 0.0072 0.002 1.1YDR067C_Skud1900.7.fasta YDR067C OCA6 3.1E+03 0.007 0.0019 1.1YLR442C_Skud1816.4.fasta YLR442C SIR3 3.1E+03 0.0167 0.0073 14.8YJL198W_Skud1642.2.fasta YJL198W PHO90 3.1E+03 0.0155 0 12.1YLR333C_Skud2002.8.fasta YLR333C RPS25B 3.1E+03 0 0 0.0YHR051W_Skud1347.2.fasta YHR051W COX6 3.1E+03 0.0127 0.0036 1.9YJR083C_Skud1940.7.fasta YJR083C ACF4 3.1E+03 0.0122 0.0018 4.1YHR178W_Skud2046.9.fasta YHR178W STB5 3.1E+03 0.0151 0.0019 9.3YGR098C_Skud1968.3.fasta YGR098C ESP1 3.1E+03 0.0128 0.0069 4.3YLR084C_Skud989.3.fasta YLR084C RAX2 3.1E+03 0.0166 0.0048 17.4YPL036W_Skud1396.1.fasta YPL036W PMA2 3.1E+03 0.0161 0.0021 13.4YGR009C_Skud1670.4.fasta YGR009C SEC9 3.1E+03 0.0152 0.0032 10.2YNL072W_Skud1657.2.fasta YNL072W RNH201 3.1E+03 0.01 0.0057 2.1

YJR059W_Skud1911.3.fasta YJR059W PTK2 3.1E+03 0.0157 0.0018 11.4YOR380W_Skud2036.6.fasta YOR380W RDR1 3.1E+03 0.0137 0.0035 6.2YDR219C_Skud1811.3.fasta YDR219C MFB1 3.1E+03 0.0126 0.0075 4.2YJR136C_Skud1942.6.fasta YJR136C TTI2 3.1E+03 0.0134 0.0047 6.0YJR080C_Skud1940.9.fasta YJR080C AIM24 3.1E+03 0.015 0.0027 5.9YBL052C_Skud1725.5.fasta YBL052C SAS3 3.1E+03 0.0153 0.0051 11.1YJL105W_Skud1954.6.fasta YJL105W SET4 3.1E+03 0.014 0.0015 5.5YPL030W_Skud1532.1.fasta YPL030W TRM44 3.1E+03 0.014 0.0027 7.1YIL087C_Skud1880.2.fasta YIL087C AIM19 3.1E+03 0.0067 0 1.0YDR026C_Skud1760.6.fasta YDR026C 3.1E+03 0.0137 0.0076 6.2YLR305C_Skud1779.1.fasta YLR305C STT4 3.1E+03 0.0172 0.0008 29.0YDR382W_Skud1592.2.fasta YDR382W RPP2B 3.1E+03 0.0001 0.0075 0.0YBL037W_Skud1851.8.fasta YBL037W APL3 3.1E+03 0.0167 0.0028 14.0YGL222C_Skud1804.8.fasta YGL222C EDC1 3.1E+03 0.0094 0.0068 2.0YFR011C_Skud1385.3.fasta YFR011C AIM13 3.1E+03 0.0126 0.0058 1.9YDR484W_Skud1730.6.fasta YDR484W VPS52 3.1E+03 0.0144 0.0008 8.1YPL021W_Skud1501.4.fasta YPL021W ECM23 3.1E+03 0.0068 0.0049 1.0YNL167C_Skud1953.4.fasta YNL167C SKO1 3.1E+03 0.015 0.0015 9.3YCR005C_Skud1966.7.fasta YCR005C CIT2 3.1E+03 0.0127 0.001 5.0YEL048C_Skud1931.7.fasta YEL048C 3.1E+03 0.013 0 2.0YLR389C_Skud2066.4.fasta YLR389C STE23 3.1E+03 0.0157 0.005 13.2YGL226W_Skud1804.3.fasta YGL226W MTC3 3.1E+03 0 0 0.0YNL126W_Skud1922.8.fasta YNL126W SPC98 3.1E+03 0.0162 0.0026 10.9YOR232W_Skud1805.7.fasta YOR232W MGE1 3.1E+03 0.0137 0 3.0YEL062W_Skud1923.8.fasta YEL062W NPR2 3.1E+03 0.0144 0.0032 8.1YNL111C_Skud1428.5.fasta YNL111C CYB5 3.1E+03 0 0 0.0YGR210C_Skud1744.7.fasta YGR210C 3.1E+03 0.012 0.0012 4.0YKL045W_Skud2056.4.fasta YKL045W PRI2 3.1E+03 0.0153 0.0045 6.9YKL120W_Skud2020.5.fasta YKL120W OAC1 3.1E+03 0.0109 0 3.0YNL293W_Skud1783.4.fasta YNL293W MSB3 3.1E+03 0.0129 0.0035 5.1YLR243W_Skud1869.6.fasta YLR243W 3.1E+03 0.0111 0 3.1YBL067C_Skud1889.8.fasta YBL067C UBP13 3.1E+03 0.0067 0.0112 1.0YHR127W_Skud1988.8.fasta YHR127W 3.1E+03 0.0137 0.0056 3.0YLR055C_Skud1993.9.fasta YLR055C SPT8 3.1E+03 0.0143 0.0061 8.1YHR003C_Skud2067.19.fasta YHR003C 3.1E+03 0.0115 0.003 3.2YJR025C_Skud1630.3.fasta YJR025C BNA1 3.1E+03 0 0 0.0YFL004W_Skud1648.4.fasta YFL004W VTC2 3.1E+03 0.0161 0.0041 10.9YKL149C_Skud1301.2.fasta YKL149C DBR1 3.1E+03 0.0121 0.0023 4.1YNL279W_Skud1277.2.fasta YNL279W PRM1 3.1E+03 0.013 0.0031 5.2YOL015W_Skud1977.3.fasta YOL015W IRC10 3.1E+03 0.0135 0.0025 6.1YKL080W_Skud1563.3.fasta YKL080W VMA5 3.1E+03 0.0114 0 3.2YMR193W_Skud1752.4.fasta YMR193W MRPL24 3.1E+03 0.0132 0.0056 2.9YNL225C_Skud1866.6.fasta YNL225C CNM67 3.1E+03 0.0154 0.0025 7.9YKL154W_Skud1487.1.fasta YKL154W SRP102 3.1E+03 0.0133 0 2.9YFL034C-B_Skud1327.2.fasta YFL034C-B MOB2 3.1E+03 0.011 0.0021 3.1YBL031W_Skud2007.10.fasta YBL031W SHE1 3.1E+03 0.0112 0.0027 3.1YPR145W_Skud2053.15.fasta YPR145W ASN1 3.1E+03 0.0141 0.0008 6.4YPR029C_Skud1841.3.fasta YPR029C APL4 3.1E+03 0.0146 0.0026 8.3YPL094C_Skud2058.8.fasta YPL094C SEC62 3.1E+03 0.014 0 3.9YDR124W_Skud1862.5.fasta YDR124W 3.1E+03 0.0145 0.0107 4.9YOR080W_Skud1829.4.fasta YOR080W DIA2 3.1E+03 0.0142 0.0041 7.3YDR118W_Skud1927.8.fasta YDR118W APC4 3.1E+03 0.0137 0.0035 7.0YDR123C_Skud1862.4.fasta YDR123C INO2 3.1E+03 0.0122 0.0036 4.2

YJL016W_Skud1835.5.fasta YJL016W 3.1E+03 0.014 0.0088 7.2YJL017W_Skud1835.4.fasta YJL017W 3.1E+03 0.014 0.0088 7.2YCL017C_Skud2072.25.fasta YCL017C NFS1 3.1E+03 0.0135 0.002 6.2YMR284W_Skud1713.4.fasta YMR284W YKU70 3.1E+03 0.0138 0.0052 6.3YHR081W_Skud1728.3.fasta YHR081W LRP1 3.1E+03 0.0127 0.0052 2.0YOL016C_Skud1977.2.fasta YOL016C CMK2 3.1E+03 0.0152 0 7.0YER044C_Skud1569.4.fasta YER044C ERG28 3.1E+03 0.0066 0 1.0YJR104C_Skud1794.3.fasta YJR104C SOD1 3.2E+03 0.0065 0 1.0YHR114W_Skud2024.5.fasta YHR114W BZZ1 3.2E+03 0.014 0.0015 7.2YPR046W_Skud1654.5.fasta YPR046W MCM16 3.2E+03 0.0126 0.0107 2.0YCR102C_Skud1751.3.fasta YCR102C 3.2E+03 0 0 0.0YDR192C_Skud1170.3.fasta YDR192C NUP42 3.2E+03 0.0132 0.0024 5.3YOR118W_Skud1746.5.fasta YOR118W RTC5 3.2E+03 0.0138 0.0026 7.1YJL122W_Skud1257.3.fasta YJL122W ALB1 3.2E+03 0.0067 0.0023 1.1YOL012C_Skud1977.6.fasta YOL012C HTZ1 3.2E+03 0 0 0.0YLR248W_Skud1857.5.fasta YLR248W RCK2 3.2E+03 0.014 0.0023 7.2YDR050C_Skud1362.3.fasta YDR050C TPI1 3.2E+03 0.01 0.0016 2.2YLL057C_Skud1882.7.fasta YLL057C JLP1 3.2E+03 0.012 0.0034 4.1YLL028W_Skud1745.3.fasta YLL028W TPO1 3.2E+03 0.0143 0.0008 7.4YDR072C_Skud1306.2.fasta YDR072C IPT1 3.2E+03 0 0 0.0YFR021W_Skud1466.2.fasta YFR021W ATG18 3.2E+03 0.0133 0.0009 5.3YKL033W-A_Skud1337.2.fasta YKL033W-A 3.2E+03 0.0069 0.0037 1.1YLL058W_Skud1882.6.fasta YLL058W 3.2E+03 0.0137 0.0043 7.1YPR134W_Skud2053.5.fasta YPR134W MSS18 3.2E+03 0.0091 0.007 2.0YMR260C_Skud2070.23.fasta YMR260C TIF11 3.2E+03 0.0064 0 1.0YGL143C_Skud1895.6.fasta YGL143C MRF1 3.2E+03 0.0119 0.0045 4.1YJR152W_Skud1830.2.fasta YJR152W DAL5 3.2E+03 0.0136 0 6.3YJR135W-A_Skud1942.5.fasta YJR135W-A TIM8 3.2E+03 0.0108 0 1.0YLR065C_Skud817.1.fasta YLR065C 3.2E+03 0.0126 0.0081 2.0YBR026C_Skud2061.4.fasta YBR026C ETR1 3.2E+03 0.0147 0.0054 5.9YML101C_Skud1950.8.fasta YML101C CUE4 3.2E+03 0.0065 0.0149 1.0YMR241W_Skud1985.10.fasta YMR241W YHM2 3.2E+03 0.014 0 4.0YDL057W_Skud1366.2.fasta YDL057W 3.2E+03 0.0107 0.0072 3.0YIL049W_Skud1236.2.fasta YIL049W DFG10 3.2E+03 0.0107 0 3.0YJR113C_Skud787.1.fasta YJR113C RSM7 3.2E+03 0.0064 0.0052 1.0YJL026W_Skud1354.4.fasta YJL026W RNR2 3.2E+03 0.0119 0 4.1YER078C_Skud1738.2.fasta YER078C ICP55 3.2E+03 0.0132 0.0039 6.1YHR176W_Skud2046.11.fasta YHR176W FMO1 3.2E+03 0.0128 0.0093 5.2YGL071W_Skud2057.12.fasta YGL071W AFT1 3.2E+03 0.0149 0.0044 10.3YLR435W_Skud1014.1.fasta YLR435W TSR2 3.2E+03 0.009 0 2.0YNL310C_Skud1034.2.fasta YNL310C ZIM17 3.2E+03 0.0063 0.0111 1.0YIL115C_Skud1925.2.fasta YIL115C NUP159 3.2E+03 0.017 0.0094 21.0YNL231C_Skud1866.2.fasta YNL231C PDR16 3.2E+03 0.0141 0.0015 4.9YMR101C_Skud1157.1.fasta YMR101C SRT1 3.2E+03 0.012 0 4.2YGL086W_Skud1808.3.fasta YGL086W MAD1 3.2E+03 0.0153 0.0063 8.8YCR077C_Skud1704.3.fasta YCR077C PAT1 3.2E+03 0.0149 0.0029 9.4YML006C_Skud2043.3.fasta YML006C GIS4 3.2E+03 0.0144 0.0034 8.3YGL246C_Skud1499.2.fasta YGL246C RAI1 3.2E+03 0.0141 0.0089 4.9YER020W_Skud1655.3.fasta YER020W GPA2 3.2E+03 0.0142 0.0052 4.9YBR148W_Skud2051.11.fasta YBR148W YSW1 3.2E+03 0.0154 0.0065 8.9YNR022C_Skud1660.7.fasta YNR022C MRPL50 3.2E+03 0.0118 0.0081 1.9YPL152W_Skud1589.2.fasta YPL152W RRD2 3.2E+03 0.0114 0.0037 3.3YBR141C_Skud2051.17.fasta YBR141C 3.2E+03 0.0105 0.0056 3.0

YOR315W_Skud1795.6.fasta YOR315W SFG1 3.2E+03 0.0117 0.0044 4.1YER019C-A_Skud1655.4.fasta YER019C-A SBH2 3.2E+03 0.0109 0 1.0_Skud1946.4.fasta 3.2E+03 0.0002 0.0181 0.0YBR175W_Skud1973.5.fasta YBR175W SWD3 3.2E+03 0.0106 0.0014 3.0YER163C_Skud1702.2.fasta YER163C 3.2E+03 0.0089 0.0088 2.0YKR046C_Skud1674.5.fasta YKR046C PET10 3.2E+03 0.0126 0.0017 2.8YOR284W_Skud1737.7.fasta YOR284W HUA2 3.2E+03 0.0068 0.0083 1.1YLR385C_Skud1643.3.fasta YLR385C SWC7 3.2E+03 0.012 0.009 1.9_Skud1885.2.fasta 3.2E+03 0.0001 0.0062 0.0_Skud1447.1.fasta 3.2E+03 0.0123 0 2.0YLR327C_Skud2002.3.fasta YLR327C TMA10 3.2E+03 0.011 0 1.0YMR186W_Skud1731.4.fasta YMR186W HSC82 3.2E+03 0.0143 0 8.3YLR144C_Skud1736.8.fasta YLR144C ACF2 3.2E+03 0.0144 0.0006 7.5YOR040W_Skud2015.7.fasta YOR040W GLO4 3.2E+03 0.0105 0.0073 3.0YMR075W_Skud1528.5.fasta YMR075W RCO1 3.2E+03 0.0136 0.0043 6.3YNL119W_Skud1922.2.fasta YNL119W NCS2 3.2E+03 0.0125 0.0019 5.1YEL034W_Skud1692.7.fasta YEL034W HYP2 3.2E+03 0.0065 0 1.0YBR181C_Skud2058.12.fasta YBR181C RPS6B 3.2E+03 0 0 0.0YFL009W_Skud1910.3.fasta YFL009W CDC4 3.2E+03 0.0145 0.005 10.0YAL034C_Skud1685.7.fasta YAL034C FUN19 3.2E+03 0.0117 0.0057 4.1YOL116W_Skud1896.9.fasta YOL116W MSN1 3.2E+03 0.0117 0.0039 4.1YGL175C_Skud1986.8.fasta YGL175C SAE2 3.2E+03 0.0138 0.0054 4.0YNL042W_Skud1809.4.fasta YNL042W BOP3 3.2E+03 0.0114 0.0011 3.3YPL224C_Skud1934.4.fasta YPL224C MMT2 3.2E+03 0.0125 0.0039 5.1YML123C_Skud1679.6.fasta YML123C PHO84 3.2E+03 0.0138 0 8.0YOR291W_Skud1838.5.fasta YOR291W YPK9 3.2E+03 0.0166 0.0047 19.7YCL054W_Skud2065.8.fasta YCL054W SPB1 3.2E+03 0.0143 0.0016 8.3YPR073C_Skud1652.2.fasta YPR073C LTP1 3.2E+03 0.0064 0 1.0YFR001W_Skud1697.4.fasta YFR001W LOC1 3.2E+03 0 0 0.0YER093C-A_Skud2009.12.fasta YER093C-A AIM11 3.2E+03 0.0001 0.0057 0.0YGR208W_Skud1744.5.fasta YGR208W SER2 3.2E+03 0.0106 0.0113 3.1YDL116W_Skud1480.2.fasta YDL116W NUP84 3.2E+03 0.0144 0.0048 9.2YDR202C_Skud1918.4.fasta YDR202C RAV2 3.2E+03 0.0115 0.0015 4.0YGL062W_Skud1952.4.fasta YGL062W PYC1 3.2E+03 0.0164 0.0008 16.8YMR131C_Skud1828.7.fasta YMR131C RRB1 3.2E+03 0.0129 0.004 6.0YHR074W_Skud1817.1.fasta YHR074W QNS1 3.2E+03 0.0142 0.0007 8.3YJR009C_Skud1691.2.fasta YJR009C TDH2 3.2E+03 0 0 0.0YMR244C-A_Skud1985.6.fasta YMR244C-A 3.2E+03 0 0.0046 0.0YOL063C_Skud1534.4.fasta YOL063C CRT10 3.2E+03 0.0163 0.0016 15.0_Skud1797.9.fasta 3.2E+03 0 0 0.0YHR149C_Skud1820.3.fasta YHR149C SKG6 3.2E+03 0.0145 0.0038 8.5YEL023C_Skud1858.3.fasta YEL023C 3.2E+03 0.0138 0.0047 7.3YJL165C_Skud1754.4.fasta YJL165C HAL5 3.2E+03 0.0146 0.0031 9.4YDR289C_Skud1767.7.fasta YDR289C RTT103 3.2E+03 0 0.0024 0.0YNL146W_Skud1924.8.fasta YNL146W 3.2E+03 0.0001 0.0145 0.0YGL047W_Skud1607.2.fasta YGL047W ALG13 3.2E+03 0.013 0 3.0YMR183C_Skud1353.2.fasta YMR183C SSO2 3.2E+03 0.0115 0 4.1YPL071C_Skud1974.13.fasta YPL071C 3.2E+03 0.0063 0.0033 1.0YNR007C_Skud1932.4.fasta YNR007C ATG3 3.2E+03 0 0.0021 0.0YHL008C_Skud2034.9.fasta YHL008C 3.2E+03 0.0138 0.0038 7.3YDL238C_Skud1369.2.fasta YDL238C GUD1 3.2E+03 0.0126 0.0114 3.7YLR052W_Skud1993.6.fasta YLR052W IES3 3.2E+03 0.0065 0.0017 1.1YJR085C_Skud1940.5.fasta YJR085C 3.2E+03 0.0105 0 1.0

YPL076W_Skud1921.6.fasta YPL076W GPI2 3.2E+03 0.013 0.0068 3.0YKL142W_Skud1823.9.fasta YKL142W MRP8 3.2E+03 0.0121 0 2.8YKL041W_Skud2056.1.fasta YKL041W VPS24 3.2E+03 0.009 0.0023 2.1YDL197C_Skud1535.2.fasta YDL197C ASF2 3.2E+03 0.0145 0.0079 6.8YML005W_Skud2043.4.fasta YML005W TRM12 3.2E+03 0 0.0042 0.0YJL107C_Skud1954.3.fasta YJL107C 3.2E+03 0.0147 0.0048 9.5YJL108C_Skud1954.2.fasta YJL108C PRM10 3.2E+03 0.0147 0.0048 9.5YHR194W_Skud1689.5.fasta YHR194W MDM31 3.2E+03 0.015 0.0026 8.0YJR088C_Skud1940.3.fasta YJR088C EMC2 3.2E+03 0.0135 0.0116 4.8YHL014C_Skud2034.3.fasta YHL014C YLF2 3.2E+03 0.0113 0.0024 4.0YPL026C_Skud1562.4.fasta YPL026C SKS1 3.2E+03 0.0147 0.0033 6.9YJR030C_Skud1630.2.fasta YJR030C 3.2E+03 0.0146 0.0076 9.4YJL049W_Skud1771.2.fasta YJL049W 3.2E+03 0.0143 0.0044 5.9YBR218C_Skud1523.3.fasta YBR218C PYC2 3.2E+03 0.016 0 17.4YLL033W_Skud1548.4.fasta YLL033W IRC19 3.2E+03 0.0088 0.0055 2.0YKR051W_Skud1397.3.fasta YKR051W 3.2E+03 0.0118 0.0011 4.2YBR203W_Skud1766.5.fasta YBR203W COS111 3.2E+03 0.0152 0.0032 13.2YIR008C_Skud1884.4.fasta YIR008C PRI1 3.2E+03 0.0113 0.0024 4.0YJR017C_Skud1630.8.fasta YJR017C ESS1 3.2E+03 0.01 0.005 0.9YNL169C_Skud1953.2.fasta YNL169C PSD1 3.2E+03 0.0124 0.0019 5.2YLR287C_Skud2059.15.fasta YLR287C 3.2E+03 0.0134 0.0079 4.0YDL164C_Skud1559.4.fasta YDL164C CDC9 3.2E+03 0.0142 0.0006 8.4YGR283C_Skud783.1.fasta YGR283C 3.2E+03 0.0134 0.0014 4.0YJR061W_Skud1911.5.fasta YJR061W 3.2E+03 0.015 0.0026 13.1YOR144C_Skud1833.7.fasta YOR144C ELG1 3.2E+03 0.0142 0.0085 8.4YGL179C_Skud1465.4.fasta YGL179C TOS3 3.2E+03 0.0127 0.005 6.0YPL163C_Skud2033.5.fasta YPL163C SVS1 3.3E+03 0.0086 0.0038 2.0_Skud1947.2.fasta 3.3E+03 0.0116 0.0128 4.1YKL078W_Skud1436.2.fasta YKL078W DHR2 3.3E+03 0.0142 0.0007 10.0YDR081C_Skud1929.2.fasta YDR081C PDC2 3.3E+03 0.015 0.002 11.4YJL143W_Skud2041.10.fasta YJL143W TIM17 3.3E+03 0.0063 0.0044 1.1YKR078W_Skud2030.15.fasta YKR078W 3.3E+03 0.0133 0.0062 7.1YPR011C_Skud1714.4.fasta YPR011C 3.3E+03 0.0103 0.0061 3.1YFL031W_Skud1132.1.fasta YFL031W HAC1 3.3E+03 0.0123 0 2.9YGL226C-A_Skud1804.2.fasta YGL226C-A OST5 3.3E+03 0.0104 0.0117 1.0YPR051W_Skud1806.3.fasta YPR051W MAK3 3.3E+03 0 0 0.0_Skud2044.6.fasta 3.3E+03 0 0 0.0YMR255W_Skud490.1.fasta YMR255W GFD1 3.3E+03 0.0118 0.0051 2.0YDR472W_Skud1959.6.fasta YDR472W TRS31 3.3E+03 0.0087 0.0033 2.0YPL088W_Skud2058.14.fasta YPL088W 3.3E+03 0.0112 0.0015 4.0YLR348C_Skud986.1.fasta YLR348C DIC1 3.3E+03 0.0126 0.0032 3.0YLR246W_Skud1869.9.fasta YLR246W ERF2 3.3E+03 0.0105 0.0039 3.1YLR034C_Skud1946.2.fasta YLR034C SMF3 3.3E+03 0.0142 0 6.8YGR085C_Skud1693.4.fasta YGR085C RPL11B 3.3E+03 0.006 0 1.0YOR237W_Skud1805.3.fasta YOR237W HES1 3.3E+03 0.0139 0.0011 5.0YOL003C_Skud1890.2.fasta YOL003C PFA4 3.3E+03 0.0114 0.004 4.1YPL091W_Skud2058.11.fasta YPL091W GLR1 3.3E+03 0.0124 0.004 5.2YDR279W_Skud1845.8.fasta YDR279W RNH202 3.3E+03 0.0103 0.0068 3.1YGR150C_Skud1690.6.fasta YGR150C DMR1 3.3E+03 0.0148 0.0061 9.6YBL025W_Skud2007.3.fasta YBL025W RRN10 3.3E+03 0 0 0.0YDL137W_Skud1961.4.fasta YDL137W ARF2 3.3E+03 0 0 0.0YGL112C_Skud2026.4.fasta YGL112C TAF6 3.3E+03 0.0139 0.003 6.7YOL143C_Skud1459.4.fasta YOL143C RIB4 3.3E+03 0.0062 0.003 1.1

YOR052C_Skud1328.3.fasta YOR052C 3.3E+03 0 0 0.0YPR037C_Skud1404.3.fasta YPR037C ERV2 3.3E+03 0 0.0021 0.0YJR099W_Skud1794.8.fasta YJR099W YUH1 3.3E+03 0.0126 0.0022 3.0YPL234C_Skud1578.4.fasta YPL234C TFP3 3.3E+03 0.0061 0 1.0YBR028C_Skud2061.5.fasta YBR028C 3.3E+03 0.0109 0.0016 3.3YFL039C_Skud1695.4.fasta YFL039C ACT1 3.3E+03 0.0116 0 4.2YER099C_Skud2009.7.fasta YER099C PRS2 3.3E+03 0.0132 0.0016 4.0YGR220C_Skud1159.2.fasta YGR220C MRPL9 3.3E+03 0.0086 0.0018 2.0YJL099W_Skud1545.2.fasta YJL099W CHS6 3.3E+03 0.0141 0.0058 9.2YGR276C_Skud1350.2.fasta YGR276C RNH70 3.3E+03 0.0111 0.0037 3.3YFL037W_Skud1695.2.fasta YFL037W TUB2 3.3E+03 0.0117 0 4.2YPR018W_Skud1887.4.fasta YPR018W RLF2 3.3E+03 0.0147 0.0034 8.8YNL116W_Skud1364.2.fasta YNL116W DMA2 3.3E+03 0.0129 0.0018 6.2YNR034W-A_Skud1741.7.fasta YNR034W-A 3.3E+03 0.0098 0 1.0YGL104C_Skud1658.2.fasta YGL104C VPS73 3.3E+03 0.0128 0.0031 6.2YDR022C_Skud1760.3.fasta YDR022C CIS1 3.3E+03 0.006 0.0098 1.0YPL096W_Skud2058.6.fasta YPL096W PNG1 3.3E+03 0.0137 0.0071 5.0YDL033C_Skud1539.2.fasta YDL033C SLM3 3.3E+03 0.012 0.0034 5.1YFR043C_Skud1972.12.fasta YFR043C IRC6 3.3E+03 0.0061 0.0078 1.0YDR253C_Skud1915.9.fasta YDR253C MET32 3.3E+03 0.0114 0.0079 2.0YEL043W_Skud1931.2.fasta YEL043W 3.3E+03 0.0157 0.0073 13.8YKL020C_Skud1981.8.fasta YKL020C SPT23 3.3E+03 0.0153 0.0034 13.5YIL122W_Skud2022.8.fasta YIL122W POG1 3.3E+03 0.0107 0.0041 3.2YBR262C_Skud2064.11.fasta YBR262C AIM5 3.3E+03 0.0001 0.0095 0.0YPL075W_Skud1921.7.fasta YPL075W GCR1 3.3E+03 0.0141 0.0031 8.5YDR468C_Skud1959.10.fasta YDR468C TLG1 3.3E+03 0.0087 0.0024 2.1YOR021C_Skud1983.9.fasta YOR021C 3.3E+03 0.0116 0.0044 2.0YLR085C_Skud989.2.fasta YLR085C ARP6 3.3E+03 0.0121 0.0046 5.1YPL001W_Skud1777.6.fasta YPL001W HAT1 3.3E+03 0.0101 0.0025 3.1YOR367W_Skud2013.5.fasta YOR367W SCP1 3.3E+03 0.0114 0 2.0YDL099W_Skud1542.3.fasta YDL099W BUG1 3.3E+03 0.0137 0.012 5.0YBL069W_Skud1889.6.fasta YBL069W AST1 3.3E+03 0.0112 0.0011 4.1YOR323C_Skud1824.3.fasta YOR323C PRO2 3.3E+03 0.0121 0.0022 5.1YPR069C_Skud1509.5.fasta YPR069C SPE3 3.3E+03 0.0101 0 3.1YNL233W_Skud1688.1.fasta YNL233W BNI4 3.3E+03 0.0149 0.0036 11.5YGL027C_Skud2052.4.fasta YGL027C CWH41 3.3E+03 0.0146 0.0018 11.3YPR188C_Skud1529.5.fasta YPR188C MLC2 3.3E+03 0.0114 0.0032 2.0YHR011W_Skud2067.10.fasta YHR011W DIA4 3.3E+03 0.0113 0.0073 4.1YOR255W_Skud1774.5.fasta YOR255W OSW1 3.3E+03 0.0059 0.0047 1.0YNL011C_Skud1566.3.fasta YNL011C 3.3E+03 0.0122 0.0011 5.2YCL035C_Skud2072.10.fasta YCL035C GRX1 3.3E+03 0.0094 0.0046 0.9YPL059W_Skud1974.1.fasta YPL059W GRX5 3.3E+03 0 0 0.0YDL098C_Skud1542.2.fasta YDL098C SNU23 3.3E+03 0.0113 0.005 2.0YML031W_Skud1957.2.fasta YML031W NDC1 3.3E+03 0.0112 0.0164 1.9YBR240C_Skud1387.2.fasta YBR240C THI2 3.3E+03 0.0112 0.001 4.1YOR111W_Skud2018.2.fasta YOR111W 3.3E+03 0.0061 0.0039 1.1YDR238C_Skud2069.11.fasta YDR238C SEC26 3.3E+03 0.0146 0 11.3YDL180W_Skud2045.8.fasta YDL180W 3.3E+03 0.0121 0.0025 5.2YOR136W_Skud1633.3.fasta YOR136W IDH2 3.3E+03 0.0101 0.0013 3.1YCL029C_Skud2072.16.fasta YCL029C BIK1 3.3E+03 0.0119 0.0034 5.1YDR273W_Skud1845.3.fasta YDR273W DON1 3.3E+03 0.0131 0.009 4.0YOR004W_Skud966.1.fasta YOR004W UTP23 3.3E+03 0.0121 0.0019 2.9YBL058W_Skud1907.6.fasta YBL058W SHP1 3.3E+03 0.0103 0 3.1

YNL023C_Skud1892.4.fasta YNL023C FAP1 3.3E+03 0.0146 0.0037 11.3YDL132W_Skud1961.9.fasta YDL132W CDC53 3.3E+03 0.0155 0.0019 12.9YLR020C_Skud2025.5.fasta YLR020C YEH2 3.3E+03 0.012 0.0026 5.1YMR187C_Skud1731.3.fasta YMR187C 3.3E+03 0.0112 0.0065 4.1YLL008W_Skud1676.3.fasta YLL008W DRS1 3.3E+03 0.0137 0.0025 9.1YDR275W_Skud1845.4.fasta YDR275W BSC2 3.3E+03 0.0123 0 3.0YJR058C_Skud1911.2.fasta YJR058C APS2 3.3E+03 0 0 0.0YNL200C_Skud1680.5.fasta YNL200C 3.3E+03 0.0083 0 2.0_Skud1886.2.fasta 3.3E+03 0.0002 0.0175 0.0YPR143W_Skud2053.13.fasta YPR143W RRP15 3.3E+03 0.0115 0.0021 2.8YIL131C_Skud1475.5.fasta YIL131C FKH1 3.3E+03 0.0119 0.001 5.1YOL026C_Skud2060.8.fasta YOL026C MIM1 3.3E+03 0.0098 0 1.0YBR011C_Skud1345.2.fasta YBR011C IPP1 3.3E+03 0.013 0 4.0YLR002C_Skud1904.5.fasta YLR002C NOC3 3.3E+03 0.0123 0.0013 5.3YDR404C_Skud1246.3.fasta YDR404C RPB7 3.3E+03 0.0058 0.0031 1.0YDL227C_Skud1979.4.fasta YDL227C HO 3.3E+03 0.0128 0.0024 6.3YGR095C_Skud1968.6.fasta YGR095C RRP46 3.3E+03 0.006 0.002 1.1YML034W_Skud1957.4.fasta YML034W SRC1 3.3E+03 0.0129 0.0075 7.1YDL046W_Skud1386.4.fasta YDL046W NPC2 3.3E+03 0.0057 0 1.0YGL129C_Skud1717.6.fasta YGL129C RSM23 3.3E+03 0.0139 0.0056 6.0YDR310C_Skud1967.2.fasta YDR310C SUM1 3.3E+03 0.0153 0.004 13.6YDL119C_Skud1471.4.fasta YDL119C 3.3E+03 0.0083 0.0015 2.0YEL071W_Skud1962.1.fasta YEL071W DLD3 3.3E+03 0.0123 0.001 6.0YIL057C_Skud1784.2.fasta YIL057C RGI2 3.3E+03 0.0109 0 1.9YBR163W_Skud1852.7.fasta YBR163W DEM1 3.3E+03 0.0144 0.0044 7.9YGL172W_Skud1986.5.fasta YGL172W NUP49 3.3E+03 0.0117 0.0034 5.1YDL100C_Skud1542.4.fasta YDL100C GET3 3.3E+03 0.0108 0.0015 4.0YGR099W_Skud1968.2.fasta YGR099W TEL2 3.3E+03 0.0147 0.0062 8.9_Skud1525.2.fasta 3.3E+03 0.012 0.0147 5.2YMR290C_Skud1793.2.fasta YMR290C HAS1 3.3E+03 0.0136 0.001 6.7YDL157C_Skud1673.5.fasta YDL157C 3.3E+03 0.0094 0.0042 1.0YPR085C_Skud1982.5.fasta YPR085C ASA1 3.3E+03 0.0105 0 3.2YOR019W_Skud1983.11.fasta YOR019W 3.3E+03 0.0132 0.0049 7.3YJL209W_Skud1990.3.fasta YJL209W CBP1 3.3E+03 0.0127 0.0008 7.0YIL066C_Skud1784.8.fasta YIL066C RNR3 3.3E+03 0.0144 0 11.2YLL007C_Skud1676.2.fasta YLL007C 3.3E+03 0.0132 0.0037 8.0YOR042W_Skud2015.8.fasta YOR042W CUE5 3.3E+03 0.0108 0.0068 4.0YCR003W_Skud1966.9.fasta YCR003W MRPL32 3.3E+03 0.0096 0.0023 1.0YGR253C_Skud1999.5.fasta YGR253C PUP2 3.3E+03 0.006 0.0017 1.1YLR197W_Skud1827.7.fasta YLR197W NOP56 3.3E+03 0.0104 0 3.2YLR022C_Skud2025.3.fasta YLR022C SDO1 3.3E+03 0.0118 0 2.9YDR494W_Skud1671.5.fasta YDR494W RSM28 3.3E+03 0.0097 0.0066 3.0YPL037C_Skud1396.2.fasta YPL037C EGD1 3.3E+03 0.0058 0 1.0YMR250W_Skud1985.2.fasta YMR250W GAD1 3.3E+03 0.0124 0.004 6.1YPR149W_Skud2053.18.fasta YPR149W NCE102 3.3E+03 0.0111 0 2.0YDR191W_Skud1170.2.fasta YDR191W HST4 3.3E+03 0.0127 0.0026 4.0YBR191W_Skud1921.3.fasta YBR191W RPL21A 3.3E+03 0 0 0.0YBR169C_Skud1973.10.fasta YBR169C SSE2 3.3E+03 0.0001 0.009 0.0YDL038C_Skud1681.1.fasta YDL038C 3.3E+03 0.0133 0.0169 7.4YDL039C_Skud1681.2.fasta YDL039C PRM7 3.3E+03 0.0133 0.0169 7.4YDR135C_Skud1908.2.fasta YDR135C YCF1 3.3E+03 0.0157 0.0023 21.0YOR175C_Skud2050.5.fasta YOR175C ALE1 3.3E+03 0.0123 0.0007 5.4YOR293W_Skud1838.3.fasta YOR293W RPS10A 3.3E+03 0.0095 0 1.0

YBR268W_Skud2064.6.fasta YBR268W MRPL37 3.4E+03 0.0001 0.0051 0.0YNL064C_Skud1596.4.fasta YNL064C YDJ1 3.4E+03 0.0109 0 4.1YGL252C_Skud1439.4.fasta YGL252C RTG2 3.4E+03 0.0118 0 5.2YLR125W_Skud1611.2.fasta YLR125W 3.4E+03 0.0093 0.0239 1.0YER049W_Skud2039.3.fasta YER049W TPA1 3.4E+03 0.0126 0.0015 7.0YIR012W_Skud1568.2.fasta YIR012W SQT1 3.4E+03 0.0113 0.0021 4.3YOR117W_Skud1746.6.fasta YOR117W RPT5 3.4E+03 0.0134 0.0012 5.9YPR049C_Skud1806.2.fasta YPR049C ATG11 3.4E+03 0.0148 0.0059 14.2YFR049W_Skud1972.6.fasta YFR049W YMR31 3.4E+03 0.0001 0.0095 0.0YIL162W_Skud1969.6.fasta YIL162W SUC2 3.4E+03 0.0125 0.0019 6.2YGR170W_Skud2063.2.fasta YGR170W PSD2 3.4E+03 0.0151 0.0035 12.8YDR339C_Skud1160.2.fasta YDR339C FCF1 3.4E+03 0.0107 0 1.9YLR362W_Skud1678.3.fasta YLR362W STE11 3.4E+03 0.0126 0.002 7.0YOL151W_Skud1876.6.fasta YOL151W GRE2 3.4E+03 0.0098 0.0087 3.1YLR179C_Skud2032.12.fasta YLR179C 3.4E+03 0.0056 0.0025 1.0YDR331W_Skud1638.5.fasta YDR331W GPI8 3.4E+03 0.0083 0.0014 2.1YDR085C_Skud1929.6.fasta YDR085C AFR1 3.4E+03 0.0121 0.0055 5.3YDR004W_Skud1100.3.fasta YDR004W RAD57 3.4E+03 0.0101 0.0068 3.2YDR182W_Skud1600.3.fasta YDR182W CDC1 3.4E+03 0.0116 0.0029 5.1YKL186C_Skud1844.3.fasta YKL186C MTR2 3.4E+03 0.0057 0 1.0YOL061W_Skud907.1.fasta YOL061W PRS5 3.4E+03 0.0114 0.002 5.0YNL088W_Skud1883.2.fasta YNL088W TOP2 3.4E+03 0.0154 0.0028 17.4YKL058W_Skud2056.17.fasta YKL058W TOA2 3.4E+03 0.0091 0 1.0YAL046C_Skud1247.4.fasta YAL046C AIM1 3.4E+03 0.0089 0 1.0YOL010W_Skud1977.8.fasta YOL010W RCL1 3.4E+03 0.0097 0.0013 3.1_Skud1872.4.fasta 3.4E+03 0.0108 0.0044 2.0YLR009W_Skud2025.16.fasta YLR009W RLP24 3.4E+03 0.0104 0 1.9YJL125C_Skud1365.2.fasta YJL125C GCD14 3.4E+03 0.0096 0.0024 3.1YBL086C_Skud1758.2.fasta YBL086C 3.4E+03 0.0113 0.0032 5.0YDR125C_Skud1862.6.fasta YDR125C ECM18 3.4E+03 0.0135 0.0068 6.0YDR476C_Skud1959.2.fasta YDR476C 3.4E+03 0.0104 0 1.9YNL019C_Skud1789.3.fasta YNL019C 3.4E+03 0.0081 0.0053 2.1YPR165W_Skud1949.5.fasta YPR165W RHO1 3.4E+03 0.0107 0 2.0YOR152C_Skud1349.2.fasta YOR152C 3.4E+03 0.0057 0.0017 1.1YBR110W_Skud1877.6.fasta YBR110W ALG1 3.4E+03 0.0108 0.0043 4.1YGR209C_Skud1744.6.fasta YGR209C TRX2 3.4E+03 0.0001 0.0051 0.0YPR144C_Skud2053.14.fasta YPR144C NOC4 3.4E+03 0.0132 0.0081 7.4YBR060C_Skud1976.6.fasta YBR060C ORC2 3.4E+03 0.0129 0.0015 7.3YBR192W_Skud1989.2.fasta YBR192W RIM2 3.4E+03 0.0096 0 3.1YBR035C_Skud1675.1.fasta YBR035C PDX3 3.4E+03 0.0079 0 2.0YGL258W_Skud1515.2.fasta YGL258W VEL1 3.4E+03 0.0107 0 2.0YOR171C_Skud2050.9.fasta YOR171C LCB4 3.4E+03 0.0122 0.0044 6.2YMR017W_Skud2054.10.fasta YMR017W SPO20 3.4E+03 0.0097 0.0046 3.1YER184C_Skud1901.6.fasta YER184C 3.4E+03 0 0 0.0YDL225W_Skud1979.6.fasta YDL225W SHS1 3.4E+03 0.0117 0.0008 5.2YPL240C_Skud1905.3.fasta YPL240C HSP82 3.4E+03 0.0131 0.0008 8.2YPL254W_Skud302.7.fasta YPL254W HFI1 3.4E+03 0.0131 0.001 5.8YNL327W_Skud1653.3.fasta YNL327W EGT2 3.4E+03 0.0148 0.0081 13.5YPL099C_Skud2058.2.fasta YPL099C AIM43 3.4E+03 0.0102 0 1.9YER103W_Skud2009.3.fasta YER103W SSA4 3.4E+03 0.012 0.0007 6.1YGL007W_Skud1881.1.fasta YGL007W BRP1 3.4E+03 0.009 0.0137 1.0YJL174W_Skud1166.2.fasta YJL174W KRE9 3.4E+03 0.0081 0.0018 2.1YOL127W_Skud2006.9.fasta YOL127W RPL25 3.4E+03 0 0 0.0

YHR035W_Skud1289.2.fasta YHR035W 3.4E+03 0.0109 0.0081 4.2YOR206W_Skud1616.5.fasta YOR206W NOC2 3.4E+03 0.0123 0.0006 6.2YML098W_Skud1950.5.fasta YML098W TAF13 3.4E+03 0.0102 0 1.9YPR091C_Skud1982.10.fasta YPR091C 3.4E+03 0.0135 0.0044 9.2YCR016W_Skud1836.6.fasta YCR016W 3.4E+03 0.0109 0.0051 2.8YLR088W_Skud1626.1.fasta YLR088W GAA1 3.4E+03 0.0123 0.0023 6.2YDR443C_Skud1894.3.fasta YDR443C SSN2 3.4E+03 0.0158 0.0018 22.3YMR001C_Skud2043.9.fasta YMR001C CDC5 3.4E+03 0.0122 0 6.2YKL057C_Skud2056.16.fasta YKL057C NUP120 3.4E+03 0.0149 0.0041 12.8YHR183W_Skud2046.5.fasta YHR183W GND1 3.4E+03 0.0113 0 4.4YPL027W_Skud1562.5.fasta YPL027W SMA1 3.4E+03 0.0113 0 2.9YOR212W_Skud1769.4.fasta YOR212W STE4 3.4E+03 0.0084 0 2.2YKL206C_Skud1772.4.fasta YKL206C ADD66 3.4E+03 0.0055 0.0016 1.0YOR384W_Skud2036.2.fasta YOR384W FRE5 3.4E+03 0.0136 0.0037 9.3_Skud1782.2.fasta 3.4E+03 0 0.0047 0.0YML096W_Skud1950.3.fasta YML096W 3.4E+03 0.0133 0.0065 6.0YDL029W_Skud1646.4.fasta YDL029W ARP2 3.4E+03 0.0093 0 3.0YBR083W_Skud1761.2.fasta YBR083W TEC1 3.4E+03 0.0121 0 6.2YLR128W_Skud1611.5.fasta YLR128W DCN1 3.4E+03 0.0104 0.009 2.0YBL013W_Skud1914.6.fasta YBL013W FMT1 3.4E+03 0.0123 0.0073 4.0YOR205C_Skud1616.4.fasta YOR205C LRC5 3.4E+03 0.0118 0.0072 6.0YGL115W_Skud2026.7.fasta YGL115W SNF4 3.4E+03 0.0119 0.0017 3.9YMR016C_Skud2054.9.fasta YMR016C SOK2 3.4E+03 0.0142 0.0039 10.6YOL112W_Skud1896.5.fasta YOL112W MSB4 3.4E+03 0.0079 0.0049 2.0_Skud1305.1.fasta 3.4E+03 0.0053 0 1.0YMR294W_Skud1793.6.fasta YMR294W JNM1 3.4E+03 0.0094 0.0085 3.1YIL009W_Skud1909.3.fasta YIL009W FAA3 3.4E+03 0.0129 0.0014 8.1YPL250C_Skud302.10.fasta YPL250C ICY2 3.4E+03 0.0001 0.0072 0.0YPR033C_Skud1603.2.fasta YPR033C HTS1 3.4E+03 0.0119 0.0019 6.1YCL001W_Skud1939.8.fasta YCL001W RER1 3.4E+03 0.0101 0 1.9YLR244C_Skud1869.7.fasta YLR244C MAP1 3.4E+03 0.0096 0.0024 3.1YPR057W_Skud1546.7.fasta YPR057W BRR1 3.4E+03 0.0094 0.0058 3.1YLR253W_Skud1857.1.fasta YLR253W 3.4E+03 0.0136 0.0009 7.8YPL173W_Skud1669.2.fasta YPL173W MRPL40 3.4E+03 0.0114 0 3.0YMR129W_Skud1828.9.fasta YMR129W POM152 3.4E+03 0.0151 0.0031 16.5YLR050C_Skud1993.4.fasta YLR050C 3.4E+03 0.01 0 1.9YNL190W_Skud1698.2.fasta YNL190W 3.4E+03 0.0078 0 2.0YPR078C_Skud1537.2.fasta YPR078C 3.4E+03 0.0093 0.0104 3.1YOR174W_Skud2050.6.fasta YOR174W MED4 3.4E+03 0.0113 0.0069 3.0YJR093C_Skud865.1.fasta YJR093C FIP1 3.4E+03 0.0095 0.0015 3.1YDL200C_Skud1535.5.fasta YDL200C MGT1 3.4E+03 0.0095 0 1.8YGR154C_Skud1477.3.fasta YGR154C GTO1 3.4E+03 0.0121 0.0042 4.0YDR357C_Skud1964.3.fasta YDR357C 3.4E+03 0.0085 0 1.0YER065C_Skud1762.6.fasta YER065C ICL1 3.4E+03 0.0117 0 5.3YDL066W_Skud1991.8.fasta YDL066W IDP1 3.4E+03 0.0121 0.0017 4.0YBL072C_Skud2009.4.fasta YBL072C RPS8A 3.4E+03 0.0053 0 1.0YDR376W_Skud1409.2.fasta YDR376W ARH1 3.4E+03 0.0131 0.004 6.0YLR196W_Skud1827.6.fasta YLR196W PWP1 3.4E+03 0.0124 0.0009 7.2YNL208W_Skud1629.2.fasta YNL208W 3.4E+03 0 0 0.0YLR229C_Skud1756.6.fasta YLR229C CDC42 3.4E+03 0 0 0.0YEL039C_Skud1692.2.fasta YEL039C CYC7 3.4E+03 0.0084 0 1.0YER155C_Skud2047.4.fasta YER155C BEM2 3.4E+03 0.0163 0.0035 29.6YLR315W_Skud1965.4.fasta YLR315W NKP2 3.4E+03 0.0099 0.0079 1.9

YCL036W_Skud2072.9.fasta YCL036W GFD2 3.4E+03 0.0125 0.0048 4.9YCR038C_Skud1781.2.fasta YCR038C BUD5 3.4E+03 0.0105 0.0058 4.2YOR338W_Skud2005.7.fasta YOR338W 3.4E+03 0.0093 0.0092 3.1YLR330W_Skud2002.6.fasta YLR330W CHS5 3.4E+03 0.0137 0.0058 8.0YIR013C_Skud1568.3.fasta YIR013C GAT4 3.4E+03 0.008 0.0043 0.9YEL058W_Skud1923.4.fasta YEL058W PCM1 3.4E+03 0.0127 0.0036 5.8YGR239C_Skud1935.2.fasta YGR239C PEX21 3.4E+03 0.009 0.0115 2.4YNR009W_Skud1932.2.fasta YNR009W NRM1 3.4E+03 0.0076 0.0021 2.0YGL137W_Skud1469.2.fasta YGL137W SEC27 3.4E+03 0.0128 0.0013 8.2YGR020C_Skud821.2.fasta YGR020C VMA7 3.4E+03 0.0083 0 1.0YNL067W_Skud1275.1.fasta YNL067W RPL9B 3.4E+03 0.0051 0 1.0YHR129C_Skud1988.10.fasta YHR129C ARP1 3.5E+03 0.0079 0.0023 2.1YDR028C_Skud2038.2.fasta YDR028C REG1 3.5E+03 0.0115 0.002 5.3YOR265W_Skud1703.5.fasta YOR265W RBL2 3.5E+03 0.0079 0 0.9YOR101W_Skud2018.10.fasta YOR101W RAS1 3.5E+03 0.0076 0.0123 2.0YOR140W_Skud1833.2.fasta YOR140W SFL1 3.5E+03 0.0136 0.004 9.6YDR405W_Skud1246.2.fasta YDR405W MRP20 3.5E+03 0.0051 0.0035 1.0YLR285W_Skud2059.17.fasta YLR285W NNT1 3.5E+03 0.0075 0.002 2.0YJR084W_Skud1940.6.fasta YJR084W CSN12 3.5E+03 0.0103 0.006 3.5YBR102C_Skud1637.2.fasta YBR102C EXO84 3.5E+03 0.0127 0.0025 8.2YJR021C_Skud1630.6.fasta YJR021C REC107 3.5E+03 0.008 0.0046 1.0YCR046C_Skud1526.3.fasta YCR046C IMG1 3.5E+03 0.0078 0 0.9YKL075C_Skud1436.4.fasta YKL075C 3.5E+03 0.0124 0.0021 5.0YML055W_Skud1726.6.fasta YML055W SPC2 3.5E+03 0.0095 0.0032 1.9YDR325W_Skud1577.2.fasta YDR325W YCG1 3.5E+03 0.0139 0.0027 12.2YHR038W_Skud1326.2.fasta YHR038W RRF1 3.5E+03 0 0.0017 0.0YDL155W_Skud1673.3.fasta YDL155W CLB3 3.5E+03 0.0103 0.0034 4.1YLR356W_Skud1319.1.fasta YLR356W 3.5E+03 0.01 0 2.0YGL004C_Skud1881.4.fasta YGL004C RPN14 3.5E+03 0.0091 0.0022 3.1YEL026W_Skud890.2.fasta YEL026W SNU13 3.5E+03 0.0078 0 0.9_Skud2049.6.fasta 3.5E+03 0.01 0 2.0YMR123W_Skud2044.8.fasta YMR123W PKR1 3.5E+03 0.0001 0.0091 0.0YLR387C_Skud2066.2.fasta YLR387C REH1 3.5E+03 0.0101 0.0067 4.1YPR075C_Skud1537.3.fasta YPR075C OPY2 3.5E+03 0.0079 0.005 2.1YBL021C_Skud1707.5.fasta YBL021C HAP3 3.5E+03 0 0.0034 0.0YHR059W_Skud1807.7.fasta YHR059W FYV4 3.5E+03 0.0079 0.0119 1.0YOL086C_Skud1263.1.fasta YOL086C ADH1 3.5E+03 0.0097 0.002 3.3_Skud2039.11.fasta 3.5E+03 0.0112 0.0019 5.2YDL145C_Skud1602.2.fasta YDL145C COP1 3.5E+03 0.0147 0.0016 15.5YKR062W_Skud1873.8.fasta YKR062W TFA2 3.5E+03 0.0114 0 3.9YCL014W_Skud2072.27.fasta YCL014W BUD3 3.5E+03 0.015 0.0114 20.0YDR143C_Skud1410.2.fasta YDR143C SAN1 3.5E+03 0.0117 0.0086 6.2YDR032C_Skud2038.5.fasta YDR032C PST2 3.5E+03 0.0051 0 1.0YLR212C_Skud1821.3.fasta YLR212C TUB4 3.5E+03 0.0102 0.001 4.1YKR044W_Skud1674.3.fasta YKR044W UIP5 3.5E+03 0.0122 0.0034 4.9YGR143W_Skud1751.4.fasta YGR143W SKN1 3.5E+03 0.0124 0.0012 7.3YOR320C_Skud1372.2.fasta YOR320C GNT1 3.5E+03 0.0128 0.0011 6.8YMR159C_Skud1956.4.fasta YMR159C ATG16 3.5E+03 0.0077 0.004 0.9YMR003W_Skud2043.11.fasta YMR003W AIM34 3.5E+03 0.0096 0.0052 1.9YPL210C_Skud1936.8.fasta YPL210C SRP72 3.5E+03 0.0129 0.0059 8.4YHR002W_Skud2067.20.fasta YHR002W LEU5 3.5E+03 0.0078 0.0013 2.1YLR053C_Skud1993.7.fasta YLR053C 3.5E+03 0.0079 0.005 1.0YNR053C_Skud1826.4.fasta YNR053C NOG2 3.5E+03 0.0107 0 2.9

YJL003W_Skud1686.3.fasta YJL003W COX16 3.5E+03 0.0081 0 1.0YGL036W_Skud2052.13.fasta YGL036W 3.5E+03 0.0146 0.0072 12.9YKR043C_Skud1674.2.fasta YKR043C 3.5E+03 0.0105 0 2.9YJR062C_Skud1911.6.fasta YJR062C NTA1 3.5E+03 0.0089 0.003 3.0YDR356W_Skud1964.2.fasta YDR356W SPC110 3.5E+03 0.0141 0.0029 10.9YLR163C_Skud2071.2.fasta YLR163C MAS1 3.5E+03 0.0099 0.0032 4.0YDR308C_Skud1967.4.fasta YDR308C SRB7 3.5E+03 0.0079 0 1.0YER186C_Skud1984.7.fasta YER186C 3.5E+03 0.0001 0.0053 0.0YCR091W_Skud1696.3.fasta YCR091W KIN82 3.5E+03 0.0119 0.0019 6.3YMR184W_Skud1353.3.fasta YMR184W ADD37 3.5E+03 0.0096 0 2.0YJL030W_Skud1454.4.fasta YJL030W MAD2 3.5E+03 0.0096 0.0028 2.0YOR069W_Skud1854.6.fasta YOR069W VPS5 3.5E+03 0.0118 0.0049 7.0YCR004C_Skud1966.8.fasta YCR004C YCP4 3.5E+03 0.0051 0.0019 1.0YJR069C_Skud1916.4.fasta YJR069C HAM1 3.5E+03 0.0097 0.0082 2.0YJL097W_Skud1739.4.fasta YJL097W PHS1 3.5E+03 0.0103 0.0087 2.8YLR443W_Skud1816.3.fasta YLR443W ECM7 3.5E+03 0.009 0 3.1YMR010W_Skud2054.3.fasta YMR010W 3.5E+03 0.0088 0.0012 3.0YER101C_Skud2009.5.fasta YER101C AST2 3.5E+03 0.009 0.0043 3.1YGL098W_Skud1919.6.fasta YGL098W USE1 3.5E+03 0.0052 0.0165 1.1YMR026C_Skud1450.2.fasta YMR026C PEX12 3.5E+03 0.0116 0.0069 4.8YLR384C_Skud1643.2.fasta YLR384C IKI3 3.5E+03 0.0125 0.0011 7.5YKR095W_Skud1574.3.fasta YKR095W MLP1 3.5E+03 0.0127 0.0047 7.6YOL132W_Skud2006.4.fasta YOL132W GAS4 3.5E+03 0.01 0.002 4.1YNL165W_Skud1953.6.fasta YNL165W 3.5E+03 0.0103 0.0025 4.2YML047C_Skud1980.8.fasta YML047C PRM6 3.5E+03 0.0113 0.0015 3.9YBR079C_Skud1489.1.fasta YBR079C RPG1 3.5E+03 0.0135 0.0015 11.3YMR157C_Skud1956.6.fasta YMR157C AIM36 3.5E+03 0.0095 0.0141 2.0YJL124C_Skud1365.3.fasta YJL124C LSM1 3.5E+03 0 0 0.0YBL039C_Skud1851.6.fasta YBL039C URA7 3.5E+03 0.0107 0.0008 4.4YKL018W_Skud1716.4.fasta YKL018W SWD2 3.5E+03 0.0115 0.0016 4.0YDR451C_Skud1234.2.fasta YDR451C YHP1 3.5E+03 0.0087 0.0058 3.0YJR011C_Skud1955.5.fasta YJR011C 3.5E+03 0 0.0015 0.0YGR212W_Skud1744.9.fasta YGR212W SLI1 3.5E+03 0.0106 0.0066 5.0YDL165W_Skud1559.3.fasta YDL165W CDC36 3.5E+03 0.0095 0 2.0YER009W_Skud1818.2.fasta YER009W NTF2 3.5E+03 0.0077 0 1.0YDR013W_Skud2061.9.fasta YDR013W PSF1 3.5E+03 0.0092 0.0025 1.9YKL046C_Skud2056.5.fasta YKL046C DCW1 3.5E+03 0.0099 0 4.1YMR135W-A_Skud1828.2.fasta YMR135W-A 3.5E+03 0.0001 0.0127 0.0YJL083W_Skud1768.2.fasta YJL083W TAX4 3.5E+03 0.0114 0.0097 6.2_Skud1834.3.fasta 3.5E+03 0.005 0.004 1.0YMR019W_Skud2054.12.fasta YMR019W STB4 3.5E+03 0.0133 0.0037 10.4YKL106W_Skud2010.7.fasta YKL106W AAT1 3.5E+03 0.0089 0.003 3.1YCR098C_Skud1992.5.fasta YCR098C GIT1 3.5E+03 0.01 0.0009 4.1YDL087C_Skud2062.4.fasta YDL087C LUC7 3.5E+03 0.0106 0.004 3.0YBR080C_Skud1489.2.fasta YBR080C SEC18 3.5E+03 0.005 0.0044 1.0YDR063W_Skud1900.4.fasta YDR063W AIM7 3.5E+03 0.0076 0.0033 1.0YPL222W_Skud1934.2.fasta YPL222W FMP40 3.5E+03 0.0131 0.0043 7.9YDL224C_Skud1979.7.fasta YDL224C WHI4 3.5E+03 0.0112 0.0015 6.1YPR129W_Skud586.1.fasta YPR129W SCD6 3.5E+03 0.0086 0 3.0YMR133W_Skud1828.5.fasta YMR133W REC114 3.5E+03 0.0099 0.0178 3.5YGR169C_Skud2063.1.fasta YGR169C PUS6 3.5E+03 0.0087 0.0024 3.1YLR225C_Skud1998.4.fasta YLR225C 3.5E+03 0.0096 0.0026 4.0YOR247W_Skud1958.8.fasta YOR247W SRL1 3.5E+03 0.0093 0.0052 2.0

YJL133W_Skud2041.2.fasta YJL133W MRS3 3.5E+03 0.0001 0.0065 0.0YDL002C_Skud1672.6.fasta YDL002C NHP10 3.5E+03 0 0 0.0_Skud1995.4.fasta 3.5E+03 0 0.0017 0.0YOR204W_Skud1616.3.fasta YOR204W DED1 3.5E+03 0.0113 0.0016 6.2YPL019C_Skud1501.2.fasta YPL019C VTC3 3.5E+03 0.0136 0.003 10.7YBR157C_Skud2051.2.fasta YBR157C ICS2 3.5E+03 0 0.0031 0.0YKR089C_Skud1490.2.fasta YKR089C TGL4 3.5E+03 0.0127 0.0036 9.2YHL009C_Skud2034.8.fasta YHL009C YAP3 3.5E+03 0.0111 0.0064 3.9YPL151C_Skud1589.3.fasta YPL151C PRP46 3.5E+03 0.0089 0.004 3.1YHR104W_Skud2024.15.fasta YHR104W GRE3 3.5E+03 0.0111 0.0017 3.9YML030W_Skud1957.1.fasta YML030W AIM31 3.5E+03 0.0068 0 0.9_Skud1888.1.fasta 3.5E+03 0.0101 0.0031 4.2YKL168C_Skud1780.5.fasta YKL168C KKQ8 3.5E+03 0.0115 0.005 6.3YLR098C_Skud1763.3.fasta YLR098C CHA4 3.5E+03 0.013 0 8.7YBR113W_Skud1877.3.fasta YBR113W 3.5E+03 0.0075 0.0089 1.0YOL139C_Skud1088.2.fasta YOL139C CDC33 3.5E+03 0.0093 0 2.0YJR159W_Skud1448.3.fasta YJR159W SOR1 3.5E+03 0.0048 0.0076 1.0YJR082C_Skud1940.8.fasta YJR082C EAF6 3.5E+03 0.0001 0.0099 0.0YHL007C_Skud2034.10.fasta YHL007C STE20 3.5E+03 0.0136 0.0025 10.8YFR002W_Skud1697.3.fasta YFR002W NIC96 3.5E+03 0.0121 0.0026 8.1YAL035W_Skud1685.4.fasta YAL035W FUN12 3.5E+03 0.0141 0.0024 12.0YNL314W_Skud1031.2.fasta YNL314W DAL82 3.5E+03 0.0071 0.0101 2.0YLR291C_Skud2059.10.fasta YLR291C GCD7 3.5E+03 0.0111 0 4.0YHR009C_Skud2067.12.fasta YHR009C TDA3 3.5E+03 0.0089 0.0008 3.2YJR063W_Skud1911.7.fasta YJR063W RPA12 3.5E+03 0.0073 0 1.0YML001W_Skud2043.8.fasta YML001W YPT7 3.5E+03 0 0 0.0YBR061C_Skud1976.4.fasta YBR061C TRM7 3.5E+03 0.0104 0 3.0YHR062C_Skud1807.4.fasta YHR062C RPP1 3.5E+03 0.01 0 2.9YPL256C_Skud302.5.fasta YPL256C CLN2 3.5E+03 0.0111 0.0029 6.1YDR077W_Skud1897.5.fasta YDR077W SED1 3.5E+03 0.011 0.0018 3.9YIL039W_Skud1799.3.fasta YIL039W TED1 3.5E+03 0.0104 0.0022 5.1YIL089W_Skud1880.4.fasta YIL089W 3.5E+03 0.0047 0.0156 1.0YAL049C_Skud915.2.fasta YAL049C AIM2 3.5E+03 0.0048 0.0078 1.0YDR236C_Skud2069.9.fasta YDR236C FMN1 3.5E+03 0.0047 0.0041 1.0YMR072W_Skud1528.2.fasta YMR072W ABF2 3.5E+03 0.0091 0 2.0YJR068W_Skud1916.3.fasta YJR068W RFC2 3.5E+03 0.0102 0.0027 3.0YER124C_Skud1822.3.fasta YER124C DSE1 3.5E+03 0.0096 0.0047 4.1YPR064W_Skud1546.1.fasta YPR064W 3.5E+03 0.0072 0.0098 1.0YDL173W_Skud2045.2.fasta YDL173W PAR32 3.5E+03 0.0069 0.0018 2.0YLR393W_Skud2066.8.fasta YLR393W ATP10 3.5E+03 0.0102 0.0019 3.0YDR429C_Skud1634.2.fasta YDR429C TIF35 3.5E+03 0.0092 0 2.0YMR155W_Skud1956.8.fasta YMR155W 3.5E+03 0.0096 0.0052 4.1YDL138W_Skud1961.3.fasta YDL138W RGT2 3.5E+03 0.0118 0.0018 7.3YBR171W_Skud1973.8.fasta YBR171W SEC66 3.5E+03 0.0089 0 1.9YJL210W_Skud1990.4.fasta YJL210W PEX2 3.5E+03 0.009 0.0086 2.0YDR466W_Skud1959.11.fasta YDR466W PKH3 3.5E+03 0.0125 0.0026 9.2YHR063C_Skud1807.3.fasta YHR063C PAN5 3.6E+03 0.0109 0 3.9YHR166C_Skud1584.2.fasta YHR166C CDC23 3.6E+03 0.0131 0 8.9YKR003W_Skud1712.1.fasta YKR003W OSH6 3.6E+03 0.0116 0 5.0YJL217W_Skud1861.4.fasta YJL217W REE1 3.6E+03 0.0001 0.0065 0.0YDR414C_Skud1527.5.fasta YDR414C ERD1 3.6E+03 0.0084 0.01 3.0YIL073C_Skud1847.6.fasta YIL073C SPO22 3.6E+03 0.0127 0.0022 10.2YML012W_Skud1245.2.fasta YML012W ERV25 3.6E+03 0.0089 0 2.0

YKR070W_Skud2030.7.fasta YKR070W 3.6E+03 0.0069 0.0048 2.0YHL003C_Skud2034.13.fasta YHL003C LAG1 3.6E+03 0.0116 0.0013 5.0YDR177W_Skud812.2.fasta YDR177W UBC1 3.6E+03 0.0089 0.0049 2.0YNL080C_Skud1628.5.fasta YNL080C EOS1 3.6E+03 0.0108 0.0014 3.9YLR459W_Skud1885.3.fasta YLR459W GAB1 3.6E+03 0.0083 0.0038 3.0YBL006C_Skud1893.3.fasta YBL006C LDB7 3.6E+03 0.0001 0.0086 0.0YOR073W_Skud1854.8.fasta YOR073W SGO1 3.6E+03 0.0107 0.0032 5.3YNL006W_Skud1479.3.fasta YNL006W LST8 3.6E+03 0.0069 0 2.0YNL201C_Skud1680.4.fasta YNL201C PSY2 3.6E+03 0.0125 0.0017 10.1YER112W_Skud1720.6.fasta YER112W LSM4 3.6E+03 0.007 0.0059 1.0YPL119C_Skud1951.7.fasta YPL119C DBP1 3.6E+03 0.0109 0.0016 6.1YPR082C_Skud1982.2.fasta YPR082C DIB1 3.6E+03 0 0.0035 0.0YDR337W_Skud1044.2.fasta YDR337W MRPS28 3.6E+03 0.009 0 2.0YDL003W_Skud1672.5.fasta YDL003W MCD1 3.6E+03 0.0115 0.0053 5.0YOR134W_Skud1633.4.fasta YOR134W BAG7 3.6E+03 0.0085 0.0048 3.1YPL093W_Skud2058.9.fasta YPL093W NOG1 3.6E+03 0.0106 0 5.3YGR082W_Skud1797.6.fasta YGR082W TOM20 3.6E+03 0 0 0.0YGR030C_Skud1665.3.fasta YGR030C POP6 3.6E+03 0.007 0.0062 1.0YDL049C_Skud1196.2.fasta YDL049C KNH1 3.6E+03 0.0045 0.0054 1.0YDR294C_Skud2003.7.fasta YDR294C DPL1 3.6E+03 0.0108 0.0026 6.1YGR254W_Skud1999.4.fasta YGR254W ENO1 3.6E+03 0.0093 0 4.0YGR256W_Skud1999.2.fasta YGR256W GND2 3.6E+03 0.0095 0.005 4.1YLR086W_Skud989.1.fasta YLR086W SMC4 3.6E+03 0.0147 0.0028 19.6YDR007W_Skud1100.6.fasta YDR007W TRP1 3.6E+03 0.0045 0.0092 1.0YNL161W_Skud1700.3.fasta YNL161W CBK1 3.6E+03 0.011 0.005 6.2YBL038W_Skud1851.7.fasta YBL038W MRPL16 3.6E+03 0.0087 0.0022 2.0YOL031C_Skud2060.3.fasta YOL031C SIL1 3.6E+03 0.0114 0.0051 5.0YCL056C_Skud2065.10.fasta YCL056C 3.6E+03 0.0067 0 0.9YOR197W_Skud1770.6.fasta YOR197W MCA1 3.6E+03 0.0095 0.0038 4.1YPL128C_Skud2019.4.fasta YPL128C TBF1 3.6E+03 0.01 0.0009 5.0YJR111C_Skud1027.2.fasta YJR111C 3.6E+03 0.0067 0 2.0YML067C_Skud1576.5.fasta YML067C ERV41 3.6E+03 0.0098 0 2.9YLR419W_Skud1928.9.fasta YLR419W 3.6E+03 0.0136 0.0038 15.1YMR074C_Skud1528.4.fasta YMR074C 3.6E+03 0.0068 0 1.0YOL009C_Skud1977.9.fasta YOL009C MDM12 3.6E+03 0.0086 0 1.9YPR114W_Skud1431.3.fasta YPR114W 3.6E+03 0.0068 0.0064 2.0YGL085W_Skud1808.2.fasta YGL085W 3.6E+03 0.0067 0.005 2.0YOR007C_Skud1007.1.fasta YOR007C SGT2 3.6E+03 0.007 0.0069 2.1YLR051C_Skud1993.5.fasta YLR051C FCF2 3.6E+03 0.0084 0 1.9YOR252W_Skud1958.12.fasta YOR252W TMA16 3.6E+03 0.0066 0 0.9YNL056W_Skud1464.3.fasta YNL056W OCA2 3.6E+03 0 0 0.0YJR004C_Skud1491.3.fasta YJR004C SAG1 3.6E+03 0.0108 0.0095 6.2YCR035C_Skud2035.8.fasta YCR035C RRP43 3.6E+03 0.0067 0.0023 2.0YJL023C_Skud1354.1.fasta YJL023C PET130 3.6E+03 0.0098 0.0084 3.0YER126C_Skud1822.5.fasta YER126C NSA2 3.6E+03 0.0084 0 1.9YDR078C_Skud1897.4.fasta YDR078C SHU2 3.6E+03 0.0044 0.0091 1.0YMR176W_Skud1860.4.fasta YMR176W ECM5 3.6E+03 0.0136 0.0067 14.4YGR177C_Skud2063.8.fasta YGR177C ATF2 3.6E+03 0.0122 0.002 7.0YBR034C_Skud1675.2.fasta YBR034C HMT1 3.6E+03 0.008 0 3.0YGL095C_Skud1919.2.fasta YGL095C VPS45 3.6E+03 0.0119 0.0019 6.8YCR026C_Skud2048.12.fasta YCR026C NPP1 3.6E+03 0.0115 0.0063 7.3YDR069C_Skud1900.9.fasta YDR069C DOA4 3.6E+03 0.0117 0.0024 8.2YCL028W_Skud2072.17.fasta YCL028W RNQ1 3.6E+03 0.0081 0.004 3.1

YGR146C_Skud1690.2.fasta YGR146C 3.6E+03 0.0084 0.0077 1.9YER156C_Skud2047.5.fasta YER156C 3.6E+03 0.0095 0 2.9YPL133C_Skud2019.9.fasta YPL133C RDS2 3.6E+03 0.0106 0.001 4.0YFR048W_Skud1972.7.fasta YFR048W RMD8 3.6E+03 0.0107 0.0029 6.2YBR252W_Skud2064.22.fasta YBR252W DUT1 3.6E+03 0 0.0034 0.0YGL063W_Skud1952.5.fasta YGL063W PUS2 3.6E+03 0.0066 0.006 2.0YMR038C_Skud1486.5.fasta YMR038C CCS1 3.6E+03 0 0 0.0YPL015C_Skud1393.2.fasta YPL015C HST2 3.6E+03 0.0103 0.0029 3.9YOR193W_Skud1770.2.fasta YOR193W PEX27 3.6E+03 0.0093 0.014 2.9YDR228C_Skud2069.2.fasta YDR228C PCF11 3.6E+03 0.0099 0.0023 5.1YIL071C_Skud1847.4.fasta YIL071C PCI8 3.6E+03 0.0091 0.0011 4.1YML038C_Skud1957.8.fasta YML038C YMD8 3.6E+03 0.008 0.0022 3.0YJR119C_Skud1903.8.fasta YJR119C JHD2 3.6E+03 0.0111 0.006 7.1YGL176C_Skud1986.9.fasta YGL176C 3.6E+03 0.0098 0.0072 5.0YBL014C_Skud1914.5.fasta YBL014C RRN6 3.6E+03 0.0124 0.01 10.2YPL131W_Skud2019.7.fasta YPL131W RPL5 3.6E+03 0.0065 0 2.0YBR286W_Skud1898.4.fasta YBR286W APE3 3.6E+03 0.0094 0.0026 4.2YGR071C_Skud1944.5.fasta YGR071C 3.6E+03 0.0127 0.0104 8.9YOR148C_Skud728.1.fasta YOR148C SPP2 3.6E+03 0.0067 0.0073 1.0YKR036C_Skud1606.5.fasta YKR036C CAF4 3.6E+03 0.0099 0.0079 5.1YIR005W_Skud843.2.fasta YIR005W IST3 3.6E+03 0.0066 0.0035 1.0YHR052W_Skud1347.3.fasta YHR052W CIC1 3.6E+03 0.0098 0.0029 3.7YPR026W_Skud1460.1.fasta YPR026W ATH1 3.6E+03 0.0129 0.0022 11.5YER188W_Skud1949.10.fasta YER188W 3.6E+03 0.0002 0.0152 0.0YPR198W_Skud1565.3.fasta YPR198W SGE1 3.6E+03 0.0093 0 4.2YML114C_Skud1963.2.fasta YML114C TAF8 3.6E+03 0.009 0.0075 4.1YGR180C_Skud2063.11.fasta YGR180C RNR4 3.6E+03 0.008 0 3.1YJL158C_Skud1663.2.fasta YJL158C CIS3 3.6E+03 0.0081 0 1.9YPL247C_Skud302.13.fasta YPL247C 3.6E+03 0.0116 0.004 6.0YOR245C_Skud1958.6.fasta YOR245C DGA1 3.6E+03 0.0102 0.0036 3.9YFL001W_Skud1697.5.fasta YFL001W DEG1 3.6E+03 0.0079 0.0033 3.0YBL098W_Skud1295.2.fasta YBL098W BNA4 3.6E+03 0.009 0.0011 4.1YML111W_Skud1963.5.fasta YML111W BUL2 3.6E+03 0.0117 0.002 8.3YER046W_Skud1073.1.fasta YER046W SPO73 3.6E+03 0.0065 0 1.0YJL041W_Skud1812.4.fasta YJL041W NSP1 3.6E+03 0.0064 0.004 1.0YIL142W_Skud1832.3.fasta YIL142W CCT2 3.6E+03 0.0113 0 5.9YPR017C_Skud1887.3.fasta YPR017C DSS4 3.6E+03 0 0.0037 0.0_Skud1818.5.fasta 3.6E+03 0 0 0.0YPR084W_Skud1982.4.fasta YPR084W 3.6E+03 0.0078 0.0021 3.0YKL188C_Skud1844.5.fasta YKL188C PXA2 3.6E+03 0.0125 0.0036 9.7YEL051W_Skud1931.10.fasta YEL051W VMA8 3.6E+03 0.0082 0.002 2.0YDR108W_Skud1293.2.fasta YDR108W GSG1 3.6E+03 0.0109 0.0028 7.1YBL036C_Skud1851.9.fasta YBL036C 3.6E+03 0.0082 0.0019 2.0YCR032W_Skud2035.5.fasta YCR032W BPH1 3.6E+03 0.0107 0.0054 6.3YKR006C_Skud1938.3.fasta YKR006C MRPL13 3.6E+03 0.0083 0.0056 2.0YNL041C_Skud1809.3.fasta YNL041C COG6 3.6E+03 0.0126 0.0024 9.8YER168C_Skud1434.3.fasta YER168C CCA1 3.6E+03 0.0044 0.0012 1.1YOR355W_Skud1930.4.fasta YOR355W GDS1 3.6E+03 0.0096 0.0029 5.0YLR150W_Skud1736.2.fasta YLR150W STM1 3.6E+03 0.0065 0 1.0YLR429W_Skud1798.4.fasta YLR429W CRN1 3.6E+03 0.0098 0.0051 5.1YDL101C_Skud1542.5.fasta YDL101C DUN1 3.6E+03 0.0108 0.0019 4.9YKL112W_Skud2020.11.fasta YKL112W ABF1 3.6E+03 0.0125 0.0062 8.9YNL291C_Skud1783.6.fasta YNL291C MID1 3.6E+03 0.0098 0.0046 5.1

YBR205W_Skud1766.3.fasta YBR205W KTR3 3.6E+03 0.0109 0.0025 5.0YMR158W_Skud1956.5.fasta YMR158W MRPS8 3.6E+03 0.0061 0 0.9YER013W_Skud1818.8.fasta YER013W PRP22 3.6E+03 0.0128 0.0042 12.3YDR368W_Skud1699.3.fasta YDR368W YPR1 3.6E+03 0.0042 0.0047 1.0YLR421C_Skud1928.11.fasta YLR421C RPN13 3.6E+03 0.0063 0 1.0YDR501W_Skud1891.5.fasta YDR501W PLM2 3.6E+03 0.0107 0.0019 4.9YBL024W_Skud2007.2.fasta YBL024W NCL1 3.6E+03 0.0119 0 7.8YDR427W_Skud1634.4.fasta YDR427W RPN9 3.6E+03 0.0094 0.0047 3.0YHR181W_Skud2046.7.fasta YHR181W SVP26 3.6E+03 0.008 0 1.9YHR106W_Skud2024.13.fasta YHR106W TRR2 3.6E+03 0.0064 0.0045 2.0YNL255C_Skud1557.2.fasta YNL255C GIS2 3.6E+03 0 0.0034 0.0YNL098C_Skud1906.5.fasta YNL098C RAS2 3.6E+03 0.0065 0.0032 2.1YGL067W_Skud2057.15.fasta YGL067W NPY1 3.6E+03 0.0101 0.0055 4.0YGR138C_Skud1585.3.fasta YGR138C TPO2 3.6E+03 0.0095 0 5.0YGL249W_Skud1499.5.fasta YGL249W ZIP2 3.6E+03 0.0102 0.0095 6.0YBR122C_Skud1759.6.fasta YBR122C MRPL36 3.6E+03 0.0061 0 1.0YPL179W_Skud1980.2.fasta YPL179W PPQ1 3.6E+03 0.0113 0.0019 6.0YBR210W_Skud1525.1.fasta YBR210W ERV15 3.6E+03 0.0001 0.0121 0.0YOR143C_Skud1833.6.fasta YOR143C THI80 3.6E+03 0.009 0 2.9YMR027W_Skud1450.3.fasta YMR027W 3.6E+03 0.0068 0.0046 2.2YMR153W_Skud1956.10.fasta YMR153W NUP53 3.6E+03 0.0107 0.0033 5.0YGL001C_Skud1881.7.fasta YGL001C ERG26 3.6E+03 0.0063 0.0015 2.0YDL108W_Skud1733.4.fasta YDL108W KIN28 3.6E+03 0.0043 0.0019 1.1YOR095C_Skud1647.3.fasta YOR095C RKI1 3.6E+03 0.008 0.0039 2.0YOR051C_Skud1328.2.fasta YOR051C 3.6E+03 0.0106 0.0054 4.9YFL012W_Skud1910.6.fasta YFL012W 3.6E+03 0.0001 0.006 0.0YNR039C_Skud1741.2.fasta YNR039C ZRG17 3.6E+03 0.0096 0.0024 5.1YER079W_Skud1738.3.fasta YER079W 3.6E+03 0.0042 0 1.0YDR212W_Skud1339.2.fasta YDR212W TCP1 3.6E+03 0.008 0 3.2YBR199W_Skud1989.9.fasta YBR199W KTR4 3.6E+03 0.0078 0.0051 3.1YNL113W_Skud791.2.fasta YNL113W RPC19 3.6E+03 0.0062 0.0039 1.0YML002W_Skud2043.7.fasta YML002W 3.6E+03 0.0121 0.0061 11.1YML003W_Skud2043.6.fasta YML003W 3.6E+03 0.0121 0.0061 11.1YLR455W_Skud1885.6.fasta YLR455W 3.6E+03 0.0076 0.0077 1.9YIL128W_Skud2022.2.fasta YIL128W MET18 3.6E+03 0.013 0.004 12.7YMR313C_Skud1561.4.fasta YMR313C TGL3 3.6E+03 0.0113 0.0032 6.8YBR183W_Skud1785.5.fasta YBR183W YPC1 3.6E+03 0.0062 0.0017 2.0YLR215C_Skud1998.13.fasta YLR215C CDC123 3.6E+03 0.01 0.006 4.0_Skud1690.4.fasta 3.6E+03 0.0057 0.0035 0.9YOR150W_Skud1064.2.fasta YOR150W MRPL23 3.6E+03 0.0059 0 1.0YER043C_Skud1569.3.fasta YER043C SAH1 3.6E+03 0.0086 0 4.0YER025W_Skud1593.2.fasta YER025W GCD11 3.6E+03 0.0079 0.0008 3.2_Skud1666.6.fasta 3.6E+03 0.0002 0.0246 0.0YDR418W_Skud1203.2.fasta YDR418W RPL12B 3.6E+03 0.0061 0 1.0YER096W_Skud2009.9.fasta YER096W SHC1 3.6E+03 0.0087 0.0028 4.1YBL101C_Skud1948.5.fasta YBL101C ECM21 3.6E+03 0.0125 0.0046 11.5YLR216C_Skud1998.12.fasta YLR216C CPR6 3.6E+03 0.0099 0 4.0YLR298C_Skud2059.5.fasta YLR298C YHC1 3.6E+03 0.0079 0.0022 2.0YMR239C_Skud1271.3.fasta YMR239C RNT1 3.6E+03 0.0062 0.0028 2.0YGR194C_Skud1691.4.fasta YGR194C XKS1 3.6E+03 0.0111 0.0043 6.0YDR155C_Skud711.2.fasta YDR155C CPR1 3.6E+03 0.0061 0.0032 1.0YEL038W_Skud1692.3.fasta YEL038W UTR4 3.6E+03 0.0001 0.0099 0.0YDR349C_Skud2047.9.fasta YDR349C YPS7 3.6E+03 0.0086 0.0029 4.1

YBR291C_Skud1455.2.fasta YBR291C CTP1 3.6E+03 0.0077 0 1.9YLR340W_Skud1721.3.fasta YLR340W RPP0 3.6E+03 0.0061 0 2.0YNL322C_Skud1096.1.fasta YNL322C KRE1 3.6E+03 0.0088 0.0017 2.9YER015W_Skud1461.2.fasta YER015W FAA2 3.6E+03 0.01 0.0019 6.1YJL031C_Skud1454.3.fasta YJL031C BET4 3.7E+03 0.0077 0 2.0YLR068W_Skud1316.2.fasta YLR068W FYV7 3.7E+03 0.0058 0.0034 1.0YGR093W_Skud1968.8.fasta YGR093W DRN1 3.7E+03 0.0077 0.0072 3.1YPL190C_Skud1252.2.fasta YPL190C NAB3 3.7E+03 0.011 0.0037 7.4YHR004C_Skud2067.18.fasta YHR004C NEM1 3.7E+03 0.0097 0.0022 3.9YOR357C_Skud1930.2.fasta YOR357C SNX3 3.7E+03 0.0001 0.0094 0.0YDR204W_Skud1918.3.fasta YDR204W COQ4 3.7E+03 0.0088 0.0016 2.9YPL211W_Skud1936.7.fasta YPL211W NIP7 3.7E+03 0.0059 0 1.0YKL009W_Skud933.1.fasta YKL009W MRT4 3.7E+03 0 0.003 0.0YJR123W_Skud1903.4.fasta YJR123W RPS5 3.7E+03 0 0 0.0YLR134W_Skud1776.5.fasta YLR134W PDC5 3.7E+03 0.0089 0.0008 4.3YIR014W_Skud1568.4.fasta YIR014W 3.7E+03 0.0039 0.0063 1.0YMR171C_Skud1608.4.fasta YMR171C EAR1 3.7E+03 0.0086 0.0017 4.1YKR098C_Skud2028.4.fasta YKR098C UBP11 3.7E+03 0.0114 0.0067 7.0YGR060W_Skud2031.1.fasta YGR060W ERG25 3.7E+03 0.006 0 2.0YGR108W_Skud2023.4.fasta YGR108W CLB1 3.7E+03 0.0086 0.0011 4.1YMR139W_Skud1802.3.fasta YMR139W RIM11 3.7E+03 0.0074 0 3.0YIL094C_Skud1880.9.fasta YIL094C LYS12 3.7E+03 0.0088 0 3.0YOR336W_Skud2005.5.fasta YOR336W KRE5 3.7E+03 0.013 0.0039 15.3YKL152C_Skud1291.1.fasta YKL152C GPM1 3.7E+03 0.0076 0 2.0YIL098C_Skud1344.1.fasta YIL098C FMC1 3.7E+03 0.0057 0.0106 1.0YPR023C_Skud1604.2.fasta YPR023C EAF3 3.7E+03 0.0088 0.0024 3.0YCR094W_Skud2040.11.fasta YCR094W CDC50 3.7E+03 0.0061 0.0037 2.1YBR092C_Skud2011.3.fasta YBR092C PHO3 3.7E+03 0.0084 0.0012 4.0YML036W_Skud1957.6.fasta YML036W CGI121 3.7E+03 0.0001 0.0061 0.0YDL206W_Skud1850.4.fasta YDL206W 3.7E+03 0.0104 0.0064 7.1YLR166C_Skud2071.5.fasta YLR166C SEC10 3.7E+03 0.0118 0.0017 8.8YPR054W_Skud1806.6.fasta YPR054W SMK1 3.7E+03 0.0073 0.0028 3.0YBR245C_Skud1651.2.fasta YBR245C ISW1 3.7E+03 0.0126 0.0019 12.5YJR127C_Skud1503.2.fasta YJR127C RSF2 3.7E+03 0.0133 0.0057 16.4YPL124W_Skud930.2.fasta YPL124W SPC29 3.7E+03 0 0.0034 0.0YGL171W_Skud1986.4.fasta YGL171W ROK1 3.7E+03 0.0098 0.0009 4.7YFL006W_Skud1648.2.fasta YFL006W 3.7E+03 0.0085 0.0023 4.1YDR226W_Skud1379.2.fasta YDR226W ADK1 3.7E+03 0.0039 0.004 1.0YER029C_Skud1757.3.fasta YER029C SMB1 3.7E+03 0.0055 0.0075 0.9YNL193W_Skud1800.5.fasta YNL193W 3.7E+03 0.0105 0.0038 5.8YPL245W_Skud1021.2.fasta YPL245W 3.7E+03 0.006 0.001 2.1YMR314W_Skud1561.3.fasta YMR314W PRE5 3.7E+03 0 0 0.0YKR045C_Skud1674.4.fasta YKR045C 3.7E+03 0 0.003 0.0YIL139C_Skud1832.5.fasta YIL139C REV7 3.7E+03 0.0072 0.0022 1.9YBR162C_Skud1852.5.fasta YBR162C TOS1 3.7E+03 0.0074 0.0021 3.1YBR004C_Skud1395.2.fasta YBR004C GPI18 3.7E+03 0.0094 0.0036 3.9YHL012W_Skud2034.5.fasta YHL012W 3.7E+03 0.0061 0.0035 2.1YOL135C_Skud2006.2.fasta YOL135C MED7 3.7E+03 0.0057 0.0086 1.0YML074C_Skud2021.2.fasta YML074C FPR3 3.7E+03 0.006 0.0024 2.1YMR234W_Skud1773.5.fasta YMR234W RNH1 3.7E+03 0 0.0023 0.0_Skud943.2.fasta 3.7E+03 0.0001 0.0118 0.0YKL166C_Skud1780.3.fasta YKL166C TPK3 3.7E+03 0.0095 0 4.0YMR049C_Skud1978.6.fasta YMR049C ERB1 3.7E+03 0.0103 0.0012 7.1

YGL123W_Skud2026.15.fasta YGL123W RPS2 3.7E+03 0 0 0.0YDR296W_Skud2003.5.fasta YDR296W MHR1 3.7E+03 0 0.004 0.0YPR201W_Skud1995.1.fasta YPR201W ARR3 3.7E+03 0.0061 0.0038 2.1YIL157C_Skud1026.2.fasta YIL157C COA1 3.7E+03 0.0055 0.0128 1.0YDR122W_Skud1862.3.fasta YDR122W KIN1 3.7E+03 0.012 0.0032 11.4YDR201W_Skud1918.5.fasta YDR201W SPC19 3.7E+03 0.0052 0 0.9YCR047C_Skud1526.2.fasta YCR047C BUD23 3.7E+03 0.0056 0.0031 1.0YMR120C_Skud2044.5.fasta YMR120C ADE17 3.7E+03 0.0106 0 6.0YMR135C_Skud1828.3.fasta YMR135C GID8 3.7E+03 0.0094 0.0033 4.0YDL078C_Skud2062.14.fasta YDL078C MDH3 3.7E+03 0.0083 0.0016 2.9YGR171C_Skud2063.3.fasta YGR171C MSM1 3.7E+03 0.0081 0.0017 4.0YDR266C_Skud2012.10.fasta YDR266C 3.7E+03 0.0082 0.0021 4.1YNL022C_Skud1892.5.fasta YNL022C 3.7E+03 0.006 0.0009 2.1YDR518W_Skud1594.3.fasta YDR518W EUG1 3.7E+03 0.0103 0.0021 5.8YHR202W_Skud1913.6.fasta YHR202W 3.7E+03 0.0083 0.0039 4.1YMR198W_Skud1482.2.fasta YMR198W CIK1 3.7E+03 0.0104 0.0067 5.9YDR126W_Skud1862.7.fasta YDR126W SWF1 3.7E+03 0.0057 0.0032 2.0_Skud1861.5.fasta 3.7E+03 0.0072 0.0052 3.1YHR124W_Skud1988.6.fasta YHR124W NDT80 3.7E+03 0.0104 0.0008 5.9YLR441C_Skud1816.5.fasta YLR441C RPS1A 3.7E+03 0.007 0 1.9YDR065W_Skud1900.6.fasta YDR065W 3.7E+03 0.0053 0.0041 1.0YLR188W_Skud2032.4.fasta YLR188W MDL1 3.7E+03 0.009 0 5.1YDR198C_Skud1918.7.fasta YDR198C RKM2 3.7E+03 0.0057 0.0028 2.0YGR076C_Skud1944.1.fasta YGR076C MRPL25 3.7E+03 0 0.0035 0.0YDR541C_Skud2016.7.fasta YDR541C 3.7E+03 0.0037 0.0027 1.0YGR059W_Skud2031.2.fasta YGR059W SPR3 3.7E+03 0.007 0.0028 3.0YGL200C_Skud1912.2.fasta YGL200C EMP24 3.7E+03 0.0054 0 1.0YER134C_Skud1358.2.fasta YER134C 3.7E+03 0.0053 0 1.0YNR061C_Skud1943.6.fasta YNR061C 3.7E+03 0.0001 0.0128 0.0YER161C_Skud1052.2.fasta YER161C SPT2 3.7E+03 0.0071 0.0069 2.0YNR001C_Skud1932.12.fasta YNR001C CIT1 3.7E+03 0.0091 0.001 3.9YBR150C_Skud2051.9.fasta YBR150C TBS1 3.7E+03 0.0107 0.0029 8.3YPL178W_Skud1957.10.fasta YPL178W CBC2 3.7E+03 0.0053 0 1.0YPL148C_Skud1266.3.fasta YPL148C PPT2 3.7E+03 0 0.0027 0.0YPR036W_Skud1404.4.fasta YPR036W VMA13 3.7E+03 0.0086 0 3.7YDL185W_Skud2045.12.fasta YDL185W TFP1 3.7E+03 0.0087 0 5.0YPR088C_Skud1982.7.fasta YPR088C SRP54 3.7E+03 0.0084 0 4.3YNL001W_Skud1932.13.fasta YNL001W DOM34 3.7E+03 0.0082 0 3.0YLR100W_Skud1763.6.fasta YLR100W ERG27 3.7E+03 0.0082 0.0031 3.0YOR267C_Skud1703.3.fasta YOR267C HRK1 3.7E+03 0.0089 0.0026 5.2_Skud1873.5.fasta 3.7E+03 0.0058 0.0023 2.1YMR305C_Skud1521.2.fasta YMR305C SCW10 3.7E+03 0.0056 0.0013 2.0YKL023W_Skud1981.5.fasta YKL023W 3.7E+03 0.0052 0.0114 1.0YDR503C_Skud1891.3.fasta YDR503C LPP1 3.7E+03 0.0036 0 1.0YIR024C_Skud1859.2.fasta YIR024C 3.7E+03 0 0.0045 0.0YMR009W_Skud2054.2.fasta YMR009W ADI1 3.7E+03 0.0051 0.003 1.0YGL043W_Skud2052.20.fasta YGL043W DST1 3.7E+03 0.0051 0.0032 1.0YNL298W_Skud1872.7.fasta YNL298W CLA4 3.7E+03 0.01 0 7.2YDR254W_Skud1915.10.fasta YDR254W CHL4 3.7E+03 0.0069 0.0044 3.1YPL072W_Skud1974.14.fasta YPL072W UBP16 3.7E+03 0.007 0.0076 3.1YML057W_Skud1726.4.fasta YML057W CMP2 3.7E+03 0.0086 0.0058 5.0YPR008W_Skud1664.3.fasta YPR008W HAA1 3.7E+03 0.0096 0.0026 6.3YJL052W_Skud1556.2.fasta YJL052W TDH1 3.7E+03 0.0069 0 2.0

YCR023C_Skud2048.8.fasta YCR023C 3.7E+03 0.008 0.0032 4.1YGL135W_Skud869.1.fasta YGL135W RPL1B 3.7E+03 0.0051 0 1.0YIL146C_Skud1210.2.fasta YIL146C ECM37 3.7E+03 0.0069 0.0009 3.1YKL007W_Skud1788.2.fasta YKL007W CAP1 3.7E+03 0.0069 0.004 2.0YOR388C_Skud2029.2.fasta YOR388C FDH1 3.7E+03 0.005 0 1.0YPL164C_Skud2033.4.fasta YPL164C MLH3 3.7E+03 0.0092 0.0055 6.1YOL103W_Skud1755.3.fasta YOL103W ITR2 3.7E+03 0.0078 0.0008 4.1YDL040C_Skud1681.3.fasta YDL040C NAT1 3.7E+03 0.0097 0.0044 7.0YPL069C_Skud1974.11.fasta YPL069C BTS1 3.7E+03 0.008 0 3.0YLR390W-A_Skud2066.6.fasta YLR390W-A CCW14 3.7E+03 0.0067 0.0045 1.9YIR029W_Skud1859.7.fasta YIR029W DAL2 3.7E+03 0.0036 0.0083 1.0YGR260W_Skud1418.2.fasta YGR260W TNA1 3.7E+03 0.007 0.0009 3.1YJL018W_Skud1835.3.fasta YJL018W 3.7E+03 0.0096 0.0042 6.3YJL019W_Skud1835.2.fasta YJL019W MPS3 3.7E+03 0.0096 0.0042 6.3YJR089W_Skud1940.2.fasta YJR089W BIR1 3.7E+03 0.0099 0.0084 7.2YKR052C_Skud1397.2.fasta YKR052C MRS4 3.7E+03 0.0037 0.0016 1.1YDL131W_Skud1961.10.fasta YDL131W LYS21 3.7E+03 0 0 0.0YNL016W_Skud1496.3.fasta YNL016W PUB1 3.7E+03 0.0068 0.0011 3.0YJR078W_Skud1940.10.fasta YJR078W BNA2 3.7E+03 0.0086 0.0035 3.9YPL243W_Skud1905.6.fasta YPL243W SRP68 3.7E+03 0.0092 0.0016 4.8YHR190W_Skud1553.5.fasta YHR190W ERG9 3.7E+03 0.0086 0.0033 3.9YPL023C_Skud1562.2.fasta YPL023C MET12 3.7E+03 0.0104 0 6.9YDR374C_Skud1687.2.fasta YDR374C 3.7E+03 0.0067 0.0068 1.9YLR312C_Skud1965.8.fasta YLR312C QNQ1 3.7E+03 0.0079 0.0148 2.9YOL055C_Skud1251.2.fasta YOL055C THI20 3.7E+03 0.0095 0 5.0_Skud1895.2.fasta 3.7E+03 0.005 0 1.0YFL011W_Skud1910.5.fasta YFL011W HXT10 3.7E+03 0.0078 0.0037 4.1YLL010C_Skud1676.5.fasta YLL010C PSR1 3.7E+03 0.0068 0.0042 2.0YPL117C_Skud1951.5.fasta YPL117C IDI1 3.7E+03 0.0066 0.0018 1.9YLR145W_Skud1736.7.fasta YLR145W RMP1 3.7E+03 0.0001 0.0079 0.0YKR009C_Skud1938.6.fasta YKR009C FOX2 3.7E+03 0.0098 0.0026 7.2YLR337C_Skud1721.4.fasta YLR337C VRP1 3.7E+03 0.0101 0.0049 7.4YBL032W_Skud2007.11.fasta YBL032W HEK2 3.7E+03 0.0035 0.0024 1.0YDR171W_Skud1516.2.fasta YDR171W HSP42 3.7E+03 0.0078 0.0176 2.9YLR007W_Skud2025.18.fasta YLR007W NSE1 3.7E+03 0.0067 0.0045 2.0YIR002C_Skud1595.3.fasta YIR002C MPH1 3.7E+03 0.0101 0.0047 8.1YJL002C_Skud1686.4.fasta YJL002C OST1 3.7E+03 0.0066 0.0043 3.0YDR263C_Skud2012.7.fasta YDR263C DIN7 3.7E+03 0.0054 0.0056 2.1YHR132C_Skud2014.16.fasta YHR132C ECM14 3.7E+03 0.0086 0.0013 3.9YGL073W_Skud2057.11.fasta YGL073W HSF1 3.7E+03 0.008 0.0025 4.3YIL010W_Skud1125.1.fasta YIL010W DOT5 3.7E+03 0.0047 0.0023 1.0YLR335W_Skud2002.9.fasta YLR335W NUP2 3.7E+03 0.0083 0.0037 4.4YNL032W_Skud1789.2.fasta YNL032W SIW14 3.7E+03 0.0065 0 2.0YMR218C_Skud1734.3.fasta YMR218C TRS130 3.7E+03 0.0116 0.0031 10.9YKL209C_Skud1772.7.fasta YKL209C STE6 3.7E+03 0.0077 0.0057 4.1YHR171W_Skud1709.2.fasta YHR171W ATG7 3.7E+03 0.0091 0.0038 4.9YHR094C_Skud1506.1.fasta YHR094C HXT1 3.7E+03 0.0076 0.0009 4.1YCR014C_Skud1836.3.fasta YCR014C POL4 3.7E+03 0.0092 0.0035 4.9YGL078C_Skud2057.7.fasta YGL078C DBP3 3.7E+03 0.0082 0 3.8YMR264W_Skud2070.19.fasta YMR264W CUE1 3.7E+03 0.0046 0.0026 1.0YPL130W_Skud2019.6.fasta YPL130W SPO19 3.7E+03 0.0001 0.0136 0.0YLR222C_Skud1998.7.fasta YLR222C UTP13 3.7E+03 0.0085 0.0045 4.0YBR125C_Skud1334.2.fasta YBR125C PTC4 3.7E+03 0.0052 0 2.0

YDR456W_Skud1543.4.fasta YDR456W NHX1 3.7E+03 0.0069 0.0007 3.2YAR008W_Skud1902.5.fasta YAR008W SEN34 3.7E+03 0.0064 0.0035 2.0YBR251W_Skud2064.23.fasta YBR251W MRPS5 3.7E+03 0.0033 0.0017 1.0YKL116C_Skud2020.8.fasta YKL116C PRR1 3.7E+03 0.0084 0.0028 3.9YHR174W_Skud2046.13.fasta YHR174W ENO2 3.7E+03 0.0038 0.0011 1.2YMR235C_Skud1773.4.fasta YMR235C RNA1 3.7E+03 0.0075 0.0038 3.0YDR023W_Skud1760.4.fasta YDR023W SES1 3.7E+03 0.0076 0.0021 3.0YDL109C_Skud1733.5.fasta YDL109C 3.7E+03 0.0081 0.007 5.0YOR070C_Skud1854.7.fasta YOR070C GYP1 3.7E+03 0.0077 0.0029 4.2YIL038C_Skud1799.2.fasta YIL038C NOT3 3.7E+03 0.009 0.0017 6.2YBR257W_Skud2064.16.fasta YBR257W POP4 3.7E+03 0 0.0033 0.0YGL184C_Skud1778.3.fasta YGL184C STR3 3.7E+03 0.0084 0.0011 4.0YDR502C_Skud1891.4.fasta YDR502C SAM2 3.7E+03 0.0075 0 3.0YER011W_Skud1818.4.fasta YER011W TIR1 3.7E+03 0 0 0.0YCR057C_Skud2008.5.fasta YCR057C PWP2 3.7E+03 0.0108 0.0015 11.0YOR002W_Skud1890.6.fasta YOR002W ALG6 3.7E+03 0.0065 0.0009 3.1YPL232W_Skud1578.2.fasta YPL232W SSO1 3.7E+03 0.0063 0 2.0YJL035C_Skud1920.1.fasta YJL035C TAD2 3.7E+03 0.0046 0.0025 1.0YHR128W_Skud1988.9.fasta YHR128W FUR1 3.7E+03 0.0043 0 0.9YGL113W_Skud2026.5.fasta YGL113W SLD3 3.7E+03 0.0093 0.0045 5.8YML042W_Skud1980.5.fasta YML042W CAT2 3.7E+03 0.0095 0.0023 6.0YGR002C_Skud1329.1.fasta YGR002C SWC4 3.7E+03 0.005 0.002 2.0YDR233C_Skud2069.6.fasta YDR233C RTN1 3.7E+03 0.0061 0.0038 1.9YDR293C_Skud2003.8.fasta YDR293C SSD1 3.7E+03 0.011 0.0019 12.1YDL211C_Skud1437.1.fasta YDL211C 3.7E+03 0.0032 0.0067 1.0YER059W_Skud2039.15.fasta YER059W PCL6 3.7E+03 0.0074 0.0024 3.0YLR181C_Skud2032.10.fasta YLR181C VTA1 3.7E+03 0.0062 0.0077 2.0YML130C_Skud1995.6.fasta YML130C ERO1 3.7E+03 0.0061 0.0068 1.9YBR040W_Skud1753.3.fasta YBR040W FIG1 3.7E+03 0 0 0.0YHR101C_Skud1294.2.fasta YHR101C BIG1 3.7E+03 0.006 0.0019 1.9YIL070C_Skud1847.3.fasta YIL070C MAM33 3.7E+03 0.0001 0.0053 0.0YMR283C_Skud1713.5.fasta YMR283C RIT1 3.7E+03 0.0081 0.0021 3.9YER123W_Skud1822.2.fasta YER123W YCK3 3.7E+03 0.0062 0 3.0YDL017W_Skud1867.4.fasta YDL017W CDC7 3.7E+03 0.0082 0 4.0YDR421W_Skud1813.3.fasta YDR421W ARO80 3.7E+03 0.0092 0.0039 7.1YMR180C_Skud1860.8.fasta YMR180C CTL1 3.7E+03 0 0.0028 0.0YPR180W_Skud1197.2.fasta YPR180W AOS1 3.7E+03 0.006 0.003 1.9YLR136C_Skud1776.2.fasta YLR136C TIS11 3.7E+03 0.0044 0.008 1.0YPR016C_Skud1887.2.fasta YPR016C TIF6 3.7E+03 0.0043 0 1.0YLR049C_Skud1993.3.fasta YLR049C 3.7E+03 0.006 0.0032 2.0YMR015C_Skud2054.8.fasta YMR015C ERG5 3.7E+03 0.0052 0.0008 2.1YGR103W_Skud1325.4.fasta YGR103W NOP7 3.7E+03 0.008 0.0016 3.9YDR145W_Skud1848.5.fasta YDR145W TAF12 3.7E+03 0.0071 0 4.0YPL215W_Skud1936.3.fasta YPL215W CBP3 3.7E+03 0.006 0 2.0YMR079W_Skud1524.2.fasta YMR079W SEC14 3.7E+03 0.0043 0 1.0YNL221C_Skud1747.3.fasta YNL221C POP1 3.7E+03 0.009 0.0067 7.1YDR146C_Skud1848.4.fasta YDR146C SWI5 3.7E+03 0.0043 0.0082 1.0YHR006W_Skud2067.15.fasta YHR006W STP2 3.7E+03 0.0061 0.0055 3.0YPL078C_Skud1921.4.fasta YPL078C ATP4 3.7E+03 0 0.0042 0.0YDL229W_Skud1629.3.fasta YDL229W SSB1 3.7E+03 0.007 0 4.0YIL126W_Skud2022.4.fasta YIL126W STH1 3.7E+03 0.0117 0.0014 13.8YOR064C_Skud1854.1.fasta YOR064C YNG1 3.7E+03 0.004 0.0048 0.9YOR332W_Skud2005.2.fasta YOR332W VMA4 3.7E+03 0 0.0023 0.0

YMR212C_Skud1558.4.fasta YMR212C EFR3 3.7E+03 0.0095 0.0032 6.9YJL110C_Skud1451.2.fasta YJL110C GZF3 3.7E+03 0.006 0.0045 3.0YPL121C_Skud1951.9.fasta YPL121C MEI5 3.7E+03 0.0041 0.0025 1.0YFR042W_Skud1262.3.fasta YFR042W KEG1 3.7E+03 0.0037 0 0.9YDL010W_Skud809.1.fasta YDL010W GRX6 3.7E+03 0.0042 0.0022 1.0YBR128C_Skud1937.3.fasta YBR128C ATG14 3.7E+03 0.003 0.0058 1.0YGL002W_Skud1881.6.fasta YGL002W ERP6 3.7E+03 0.0042 0 1.0YKR008W_Skud1938.5.fasta YKR008W RSC4 3.7E+03 0.0089 0 5.8YGR173W_Skud2063.5.fasta YGR173W RBG2 3.7E+03 0.0059 0 2.0YBL011W_Skud1914.7.fasta YBL011W SCT1 3.7E+03 0.0077 0.0026 5.0YMR293C_Skud1793.5.fasta YMR293C HER2 3.7E+03 0.003 0.0029 1.0YGR211W_Skud1744.8.fasta YGR211W ZPR1 3.7E+03 0.0049 0.002 2.1YMR242C_Skud1985.9.fasta YMR242C RPL20A 3.7E+03 0 0.0046 0.0YKL151C_Skud1291.2.fasta YKL151C 3.7E+03 0.0059 0.003 2.0YOL028C_Skud2060.6.fasta YOL028C YAP7 3.7E+03 0.0078 0.007 4.0YOL029C_Skud2060.5.fasta YOL029C 3.7E+03 0.0078 0.007 4.0YER001W_Skud1819.4.fasta YER001W MNN1 3.7E+03 0.0078 0.005 5.1YML007W_Skud2043.2.fasta YML007W YAP1 3.7E+03 0.0061 0.0054 3.1YDR197W_Skud1918.8.fasta YDR197W CBS2 3.7E+03 0.0058 0.0037 2.0YPL154C_Skud1190.2.fasta YPL154C PEP4 3.7E+03 0.007 0 3.0YNL084C_Skud1232.2.fasta YNL084C END3 3.7E+03 0.0001 0.0062 0.0YBR198C_Skud1989.8.fasta YBR198C TAF5 3.7E+03 0.0087 0.0006 7.0YNL217W_Skud1384.2.fasta YNL217W 3.7E+03 0.0057 0.0016 2.0YDR465C_Skud1959.12.fasta YDR465C RMT2 3.7E+03 0.0067 0.0013 2.9YMR232W_Skud1283.2.fasta YMR232W FUS2 3.7E+03 0.0077 0.0007 4.0YJL196C_Skud1987.2.fasta YJL196C ELO1 3.8E+03 0.0057 0 2.0YHR017W_Skud2067.3.fasta YHR017W YSC83 3.8E+03 0.0057 0.0038 2.0_Skud1932.9.fasta 3.8E+03 0.0038 0.0019 0.9YMR178W_Skud1860.6.fasta YMR178W 3.8E+03 0.004 0 1.0YPR072W_Skud1652.3.fasta YPR072W NOT5 3.8E+03 0.0083 0 5.0YMR125W_Skud2044.10.fasta YMR125W STO1 3.8E+03 0.0093 0.0034 6.9YHR170W_Skud1709.3.fasta YHR170W NMD3 3.8E+03 0.0075 0 3.9YGL003C_Skud1881.5.fasta YGL003C CDH1 3.8E+03 0.0058 0.0009 3.0YBR041W_Skud1753.4.fasta YBR041W FAT1 3.8E+03 0.0083 0.006 5.0YDR301W_Skud1321.2.fasta YDR301W CFT1 3.8E+03 0.0108 0.0011 13.2YPL068C_Skud1974.10.fasta YPL068C 3.8E+03 0 0.0033 0.0YOL011W_Skud1977.7.fasta YOL011W PLB3 3.8E+03 0.0068 0.0021 4.1YGL225W_Skud1804.5.fasta YGL225W VRG4 3.8E+03 0.0056 0 2.0YPL070W_Skud1974.12.fasta YPL070W MUK1 3.8E+03 0.0047 0.0022 2.1YCR012W_Skud1836.2.fasta YCR012W PGK1 3.8E+03 0.0067 0 3.0YOR078W_Skud1829.6.fasta YOR078W BUD21 3.8E+03 0.0001 0.0082 0.0YIL002C_Skud1620.2.fasta YIL002C INP51 3.8E+03 0.0081 0.0015 6.1YNL024C_Skud1892.3.fasta YNL024C 3.8E+03 0 0.0042 0.0YJR050W_Skud1020.2.fasta YJR050W ISY1 3.8E+03 0.0038 0.0069 1.0YGR162W_Skud1871.4.fasta YGR162W TIF4631 3.8E+03 0.0077 0.0014 5.3YJL095W_Skud1739.2.fasta YJL095W BCK1 3.8E+03 0.0111 0.0022 13.7YJL006C_Skud1552.2.fasta YJL006C CTK2 3.8E+03 0.0053 0.0032 1.9YIL090W_Skud1880.5.fasta YIL090W ICE2 3.8E+03 0.0038 0 1.0YJL044C_Skud1920.4.fasta YJL044C GYP6 3.8E+03 0.0063 0.0047 2.9YDR099W_Skud1801.4.fasta YDR099W BMH2 3.8E+03 0.0038 0 1.0YBR133C_Skud1937.8.fasta YBR133C HSL7 3.8E+03 0.0074 0.0011 5.1YOR109W_Skud2018.4.fasta YOR109W INP53 3.8E+03 0.0093 0.0004 9.1YHR080C_Skud1728.2.fasta YHR080C 3.8E+03 0.0103 0.0068 11.5

YBR096W_Skud1359.2.fasta YBR096W 3.8E+03 0.0037 0.0049 1.0YLL045C_Skud1355.2.fasta YLL045C RPL8B 3.8E+03 0.0037 0 1.0YLR242C_Skud1869.5.fasta YLR242C ARV1 3.8E+03 0.0053 0 2.0YJL014W_Skud1835.7.fasta YJL014W CCT3 3.8E+03 0.0063 0 2.9YPR083W_Skud1982.3.fasta YPR083W MDM36 3.8E+03 0.0072 0.0043 4.0YDR061W_Skud1900.2.fasta YDR061W 3.8E+03 0.0043 0.001 2.0YMR246W_Skud1985.4.fasta YMR246W FAA4 3.8E+03 0.0071 0.0008 5.0YLR231C_Skud1756.2.fasta YLR231C BNA5 3.8E+03 0.0027 0.0021 1.0YDR393W_Skud1446.3.fasta YDR393W SHE9 3.8E+03 0.0052 0.0053 2.0YDR446W_Skud1894.6.fasta YDR446W ECM11 3.8E+03 0.0035 0.0065 1.0YCR105W_Skud1992.3.fasta YCR105W ADH7 3.8E+03 0.0001 0.005 0.0YDL080C_Skud2062.12.fasta YDL080C THI3 3.8E+03 0.0044 0.0022 2.1YJL039C_Skud1812.3.fasta YJL039C NUP192 3.8E+03 0.0115 0.0029 17.0YLR056W_Skud1993.10.fasta YLR056W ERG3 3.8E+03 0.0051 0.0015 2.0YLR267W_Skud1237.2.fasta YLR267W BOP2 3.8E+03 0.0068 0.0048 3.9YGR222W_Skud995.2.fasta YGR222W PET54 3.8E+03 0.0034 0.0069 1.0YIL143C_Skud1832.2.fasta YIL143C SSL2 3.8E+03 0.008 0 7.0YGL110C_Skud2026.2.fasta YGL110C CUE3 3.8E+03 0.006 0.0084 2.9YDL160C_Skud1255.1.fasta YDL160C DHH1 3.8E+03 0.006 0 2.9YNL055C_Skud1464.2.fasta YNL055C POR1 3.8E+03 0.0034 0 1.0YIL014W_Skud1960.3.fasta YIL014W MNT3 3.8E+03 0.0075 0.0017 4.9YGR106C_Skud2023.3.fasta YGR106C VOA1 3.8E+03 0.0001 0.0063 0.0YKL107W_Skud2010.8.fasta YKL107W 3.8E+03 0.0033 0.0017 1.0YPL160W_Skud2033.8.fasta YPL160W CDC60 3.8E+03 0.0084 0.0023 8.1YNL005C_Skud1479.4.fasta YNL005C MRP7 3.8E+03 0.0032 0.0037 1.0YIL072W_Skud1847.5.fasta YIL072W HOP1 3.8E+03 0.0067 0 3.9YNL035C_Skud1789.5.fasta YNL035C 3.8E+03 0.0033 0.0059 1.0YLR412W_Skud1928.3.fasta YLR412W BER1 3.8E+03 0.0033 0.0019 1.0YLR353W_Skud1341.3.fasta YLR353W BUD8 3.8E+03 0.0027 0.0036 1.1YER069W_Skud1843.2.fasta YER069W ARG5,6 3.8E+03 0.0079 0.0034 5.9YGR066C_Skud1944.9.fasta YGR066C 3.8E+03 0.0032 0.007 1.0YPR056W_Skud1546.8.fasta YPR056W TFB4 3.8E+03 0.0032 0.0015 1.0YMR243C_Skud1985.8.fasta YMR243C ZRC1 3.8E+03 0.0024 0.0012 1.0YPL115C_Skud1951.3.fasta YPL115C BEM3 3.8E+03 0.0082 0.0021 8.1YER106W_Skud1711.2.fasta YER106W MAM1 3.8E+03 0.0032 0.0041 1.0YLR172C_Skud2071.10.fasta YLR172C DPH5 3.8E+03 0.0032 0 1.0YLR004C_Skud1904.3.fasta YLR004C THI73 3.8E+03 0.0056 0.001 2.9YLR219W_Skud1998.10.fasta YLR219W MSC3 3.8E+03 0.0067 0.0035 5.2YOR244W_Skud1958.5.fasta YOR244W ESA1 3.8E+03 0.0045 0 2.0YDR018C_Skud2061.14.fasta YDR018C 3.8E+03 0.0045 0.004 2.0YFL027C_Skud1198.2.fasta YFL027C GYP8 3.8E+03 0.0044 0.0068 1.9YDL085W_Skud2062.7.fasta YDL085W NDE2 3.8E+03 0.0054 0.002 2.9YIL035C_Skud1694.5.fasta YIL035C CKA1 3.8E+03 0.003 0.0039 1.0YDL015C_Skud1867.3.fasta YDL015C TSC13 3.8E+03 0.0028 0.0037 0.9YMR177W_Skud1860.5.fasta YMR177W MMT1 3.8E+03 0.0044 0.0039 2.0YOL076W_Skud1718.2.fasta YOL076W MDM20 3.8E+03 0.0071 0.0059 5.7YHR078W_Skud1323.2.fasta YHR078W 3.8E+03 0.0022 0.0019 1.0YDR460W_Skud1572.4.fasta YDR460W TFB3 3.8E+03 0.0027 0 0.9YMR261C_Skud2070.22.fasta YMR261C TPS3 3.8E+03 0.0086 0.0015 9.0YOL021C_Skud2060.13.fasta YOL021C DIS3 3.8E+03 0.0082 0.0024 8.0YDR359C_Skud1964.5.fasta YDR359C EAF1 3.8E+03 0.0062 0.0034 5.1YIL026C_Skud1791.4.fasta YIL026C IRR1 3.8E+03 0.0087 0.0036 9.8YML035C_Skud1957.5.fasta YML035C AMD1 3.8E+03 0.0066 0.0012 4.9

YJL146W_Skud2041.13.fasta YJL146W IDS2 3.8E+03 0 0.0038 0.0YOR075W_Skud1829.9.fasta YOR075W UFE1 3.8E+03 0.0027 0.0046 1.0YOR262W_Skud1703.7.fasta YOR262W 3.8E+03 0.0027 0 1.0YDR524C_Skud2001.3.fasta YDR524C AGE1 3.8E+03 0.0041 0.0044 2.0YBR259W_Skud2064.14.fasta YBR259W 3.8E+03 0.0034 0.0111 2.0YML126C_Skud1995.10.fasta YML126C ERG13 3.8E+03 0.004 0 2.0YLR173W_Skud2071.11.fasta YLR173W 3.8E+03 0.0049 0.0034 2.9YKR011C_Skud2000.2.fasta YKR011C 3.8E+03 0.0025 0.0062 1.0YER003C_Skud1819.2.fasta YER003C PMI40 3.8E+03 0.0025 0 1.0YMR047C_Skud1978.8.fasta YMR047C NUP116 3.8E+03 0.007 0.0045 6.9YGL016W_Skud1875.7.fasta YGL016W KAP122 3.8E+03 0.0042 0.0024 3.1YNL091W_Skud1883.4.fasta YNL091W NST1 3.8E+03 0.0069 0.0032 8.0YDR166C_Skud1810.2.fasta YDR166C SEC5 3.8E+03 0.0058 0.0031 4.9YMR012W_Skud2054.5.fasta YMR012W CLU1 3.8E+03 0.0076 0.0032 8.9YBR118W_Skud1759.2.fasta YBR118W TEF2 3.8E+03 0.0022 0 1.0YGR083C_Skud1797.7.fasta YGR083C GCD2 3.8E+03 0.0022 0.001 1.0YMR179W_Skud1860.7.fasta YMR179W SPT21 3.8E+03 0.0029 0.0026 2.0YEL042W_Skud1931.1.fasta YEL042W GDA1 3.8E+03 0.002 0.001 1.0YLR396C_Skud2066.11.fasta YLR396C VPS33 3.8E+03 0.0031 0.0036 2.0YLL029W_Skud1745.4.fasta YLL029W FRA1 3.8E+03 0.0039 0.0021 3.0YCR053W_Skud2008.3.fasta YCR053W THR4 3.8E+03 0.0018 0.0032 1.0YDR481C_Skud1730.3.fasta YDR481C PHO8 3.8E+03 0.0016 0 1.0YLR249W_Skud1857.4.fasta YLR249W YEF3 3.8E+03 0.0037 0 3.9YIL013C_Skud1960.2.fasta YIL013C PDR11 3.8E+03 0.0043 0.0011 5.9

3E+04

2E-020.0207

The "GAL?" column shows whether a gene is a GAL gene (Y) or not (N), or whether it is adjacent (A).

n S N NGdS NGdN bp GAL? AA?116.0 173.9 468.1 1.8589 0.2331 642 Y N141.3 196.9 505.1 1.4556 0.2467 702 Y N102.2 153.8 404.2 1.4611 0.2268 558 Y N

53.7 76.9 271.1 1.2717 0.197 348 Y N118.6 299.7 867.3 0.7732 0.1252 ### A N317.5 425.6 1101.4 0.5926 0.2562 ### Y N148.2 294.4 785.6 0.5 0.1724 ### Y N

8.2 341.6 840.4 0.3889 0.01 ### N Y2.1 22.7 79.3 0.2697 0.0254 102 N N

266.5 704.1 1911.9 0.2626 0.1268 ### A N1.0 33.8 185.2 0.1421 0.0058 219 N Y

31.9 264.4 668.6 0.2602 0.0432 933 A N4.1 168.2 407.8 0.2298 0.0113 576 N N

15.3 302.8 786.2 0.1803 0.0181 ### N N53.2 777.5 2054.5 0.1732 0.0242 ### N N

8.2 322 797 0.171 0.0094 ### N Y7.1 324.2 770.8 0.1708 0.0084 ### N N

16.5 572.5 1323.5 0.1797 0.011 ### A N6.1 275.1 738.9 0.1529 0.0077 ### N N8.0 240.7 626.3 0.147 0.0121 867 N N

14.0 170.9 423.1 0.1522 0.03 594 N N16.6 287.6 762.4 0.1339 0.0203 ### N N23.8 162.7 425.3 0.1301 0.0524 588 N N11.3 365.2 939.8 0.1315 0.0111 ### N Y

1.0 346.7 949.3 0.1251 0.001 ### N N6.2 271.6 802.4 0.1088 0.0075 ### N N

22.2 365.2 1047.8 0.1173 0.0201 ### N N16.1 279.5 755.5 0.1225 0.0199 ### N N24.2 337.5 910.5 0.1179 0.0251 ### N N46.5 1032.3 2717.7 0.1184 0.016 ### N N46.5 1032.3 2717.7 0.1184 0.016 ### N N

7.0 376.6 991.4 0.1077 0.0067 ### N N6.0 171.9 572.1 0.088 0.0105 744 N N

18.6 612.4 1418.6 0.1209 0.0117 ### N N14.1 582.6 1568.4 0.1027 0.0085 ### N N18.3 232.1 676.9 0.1069 0.0255 909 N N15.2 308.5 819.5 0.1109 0.0169 ### N N

8.0 447.2 1472.8 0.09 0.0054 ### N N6.3 309.8 731.2 0.1081 0.0076 ### N N

) and Portuguese (ZP591) reference strains.Hittinger et al.

) are shown in bold and sorted by the maximum likelihood estimate of dS (MLdS).-values based on Poisson sampling of of the genome-wide average dS of 0.0207.

) substitutions, and the number of synonymous (S) and non-synonymous (N) sites estimated by ML are shown.) are shown, but no genes had significantly elevated dN/dS ratios after Bonferroni-corrected C2 tests.

ORFs with annotated single-copy orthologs in S. cerevisiae have systematic names, common names, and descriptions that correspond to the characterized S. cerevisiaeFor significantly divergent genes, putative homologs and functions were assigned based on synteny (when available) and the best BLASTX score to the S. cerevisiae

The "AA?" column shows whether a gene is involved in amino acid transport or metabolism in S. cerevisiae (Y) or not (N).), and genes involved in amino acid transport and metabolism (P < 10-5) are over-represented among highly divergent genes.

3.0 413.1 1071.9 0.1035 0.0026 ### N Y21.7 565.8 1192.2 0.0946 0.0165 ### N N20.7 276.5 677.5 0.1025 0.0273 954 N N22.8 827.9 2037.1 0.0988 0.01 ### N N

3.0 623.2 1761.8 0.0879 0.0016 ### N Y18.9 497.3 1119.7 0.1087 0.0145 ### N Y11.3 484.5 1264.5 0.0862 0.0082 ### N N

7.6 400.6 1144.4 0.0785 0.0065 ### N N9.2 308.7 810.3 0.084 0.0104 ### N N5.1 451 1265 0.0771 0.0038 ### N N2.1 471.4 1148.6 0.0873 0.0016 ### N N3.0 507.4 1301.6 0.0846 0.0021 ### N N6.1 267.6 743.4 0.076 0.0078 ### N Y

11.2 389.2 1065.8 0.0866 0.0095 ### N N7.0 346.7 964.3 0.0672 0.007 ### N Y6.2 427.5 973.5 0.076 0.0057 ### N Y2.1 601 1172 0.0806 0.0015 ### N N5.1 488.8 1185.2 0.0623 0.004 ### N Y

10.0 867.3 2633.7 0.0485 0.0039 ### N N7.1 193.5 574.5 0.0756 0.012 768 N N6.1 219.1 725.9 0.067 0.0085 945 N N1.0 246.9 614.1 0.0815 0.0015 861 N N4.1 382.1 1009.9 0.0649 0.0037 1392 N N2.0 179.1 459.9 0.0972 0.004 639 N N1.0 136.4 298.6 0.1125 0.003 435 N N7.3 282.6 611.4 0.081 0.0103 894 A N

10.1 289.1 619.9 0.0667 0.0153 909 N N4.1 413.5 885.5 0.0789 0.0039 1299 N N

12.2 273.4 836.6 0.0637 0.014 1110 N N5.1 895.4 2026.6 0.0544 0.0022 2922 N N4.0 380.3 1242.7 0.0505 0.0032 1623 N N0.0 14.5 36.5 0.2628 0 51 N0.0 41.7 120.3 0.1342 0 162 N N2.1 422.2 1146.8 0.0592 0.0016 1569 N N

11.0 515.5 1713.5 0.0477 0.0063 2229 N N6.0 248.8 708.2 0.0634 0.0081 957 N N

13.3 780.2 2138.8 0.0473 0.0058 2919 N N5.0 550.8 1843.2 0.0457 0.0027 2394 N N2.0 180.3 602.7 0.0649 0.0033 783 N N2.0 292.2 910.8 0.0528 0.0022 1203 N N4.0 162.1 812.9 0.0494 0.0051 975 N N1.0 242.8 735.2 0.0542 0.0013 978 N N5.0 522.5 1211.5 0.0563 0.0037 1734 N N1.1 364.6 1174.4 0.0487 0.0008 1539 N N1.0 166 458 0.0625 0.0021 624 N N

11.4 74 178 0.103 0.0555 252 N N6.0 437.6 1203.4 0.0549 0.0047 1641 N N4.9 376.7 1147.3 0.053 0.0041 1524 N N6.1 442.7 1264.3 0.0521 0.0045 1707 N N1.0 348.8 1205.2 0.0446 0.0008 1554 N N1.0 348.8 1205.2 0.0446 0.0008 1554 N5.1 579.8 1643.2 0.0495 0.0029 2223 N N1.0 233.7 627.3 0.0706 0.0015 861 N N

3.1 895.2 2371.8 0.0458 0.0012 3267 N N0.0 327.7 1022.3 0.0512 0 1350 N N1.0 269.9 828.1 0.0553 0.0023 1098 N N6.1 363.1 995.9 0.0513 0.0058 1359 N Y5.2 769.2 2002.8 0.0475 0.0023 2772 N N

17.1 738.2 2309.8 0.0388 0.0072 3048 N N30.2 706.7 1639.3 0.0518 0.0164 2346 N N

1.0 87.2 317.8 0.0664 0.0032 405 N N2.0 46.8 151.2 0.0921 0.0133 198 N0.0 47.6 111.4 0.1172 0 159 N4.2 198.7 509.3 0.0594 0.0084 708 N N

11.2 199.7 754.3 0.0518 0.0147 954 N N8.0 291.9 935.1 0.0494 0.0082 1227 N N9.1 357.6 935.4 0.0515 0.0089 1293 N N9.3 263 622 0.0578 0.0136 885 N N6.1 526.4 1636.6 0.0432 0.0035 2163 N N1.0 147.8 410.2 0.0611 0.0024 558 N N1.0 96.1 398.9 0.0615 0.0025 495 N N6.2 72.6 254.4 0.0682 0.0244 327 N N4.1 462.4 1103.6 0.0543 0.0033 1566 N N

17.8 98.2 264.8 0.0749 0.0601 363 N N1.0 270.9 1064.1 0.0393 0.001 1335 N N

15.4 240.9 614.1 0.0604 0.0229 855 N N10.1 681.2 2102.8 0.039 0.0046 2784 N N

7.9 681.7 2081.3 0.0392 0.0037 2763 N N12.2 437.5 1122.5 0.0486 0.0101 1560 N N

6.1 127.1 427.9 0.0592 0.014 555 N18.4 685.8 1765.2 0.0457 0.0095 2451 N N28.9 373.6 1036.4 0.0495 0.0262 1410 N N28.9 373.6 1036.4 0.0495 0.0262 1410 N N

7.1 278.1 732.9 0.0566 0.0089 1011 N N6.0 343.1 859.9 0.0556 0.0064 1203 N N2.0 157.9 529.1 0.0534 0.0038 687 N N

11.1 512.7 1224.3 0.0506 0.0082 1737 N N9.0 410.9 1194.1 0.0417 0.0073 1605 N N3.0 131.6 435.4 0.0637 0.0067 567 N N8.1 283.1 589.9 0.0669 0.0118 873 N N0.0 283.5 1051.5 0.0369 0 1335 N N

10.9 556.4 1621.6 0.0405 0.0065 2178 N N0.0 82.6 202.4 0.0804 0 285 N N4.0 223.9 706.1 0.0512 0.0055 930 N N0.0 164.2 414.8 0.0658 0 579 N N0.0 82.8 307.2 0.0595 0 390 N N4.1 387.3 848.7 0.0533 0.0042 1236 N N4.1 526.4 1318.6 0.0496 0.0028 1845 N N

11.4 421.9 1474.1 0.0388 0.0075 1896 N N6.1 746 1855 0.0444 0.003 2601 N N1.0 322.6 859.4 0.0491 0.0011 1182 N N1.0 111.1 383.9 0.0605 0.0026 495 N N0.0 85.4 226.6 0.0701 0 312 N N2.1 229.1 712.9 0.0494 0.0027 942 N N1.0 112 338 0.0636 0.0028 450 N N1.0 86 235 0.0735 0.004 321 N N

2.0 86 229 0.0627 0.0087 315 N N0.0 112.3 448.7 0.05 0 561 N N2.1 62.9 144.1 0.0774 0.0132 207 N N4.2 434.3 1665.7 0.0384 0.0024 2100 N N0.0 64 242 0.0647 0 306 N N1.0 89.2 501.8 0.0552 0.0021 591 N N1.0 144.3 311.7 0.0698 0.0029 456 N N

11.3 543.4 1286.6 0.0488 0.0077 1830 N Y3.0 267.9 629.1 0.0569 0.0043 897 N N6.1 144.8 542.2 0.0469 0.0113 687 N N0.0 22.7 49.3 0.119 0 72 N0.0 270.3 920.7 0.0443 0 1191 N N8.1 371.1 1056.9 0.045 0.0073 1428 N N3.0 147.9 521.1 0.0491 0.0058 669 N N1.0 306.3 668.7 0.0491 0.0014 975 N N2.0 209.2 483.8 0.0621 0.0037 693 N N0.0 23.8 84.2 0.0842 0 108 N N7.0 211 569 0.054 0.0116 780 N N2.1 631.1 1480.9 0.0404 0.0012 2112 N Y3.0 95.3 291.7 0.0647 0.0099 387 N N4.0 215.5 861.5 0.0378 0.0048 1077 N N3.0 248.1 837.9 0.0405 0.0036 1086 N N

14.2 604.3 1279.7 0.0478 0.0096 1884 N N3.1 284.1 618.9 0.0531 0.0044 903 N N2.1 251.4 684.6 0.0486 0.0034 936 N N0.0 388.9 1141.1 0.0399 0 1530 N N6.2 681.8 1865.2 0.0375 0.0033 2547 N N1.0 354.4 1145.6 0.0393 0.0009 1500 N N2.0 354.7 965.3 0.0478 0.0019 1320 N N

17.8 758.6 1710.4 0.0433 0.0092 2469 N N5.0 497.6 1386.4 0.0407 0.0034 1884 N N1.0 320.7 1227.3 0.0382 0.0008 1548 N N7.1 253.8 727.2 0.0475 0.0092 981 N N3.0 535.8 1654.2 0.035 0.0018 2190 N N1.0 190.6 445.4 0.0578 0.002 636 N N3.1 323.3 960.7 0.0429 0.003 1284 N N

18.5 255.6 644.4 0.0517 0.0262 900 N N1.0 190.8 469.2 0.055 0.002 660 N N3.0 223 737 0.0433 0.004 960 N N3.0 291.5 734.5 0.0494 0.0038 1026 N N1.0 326 1000 0.0432 0.001 1326 N N2.0 75 288 0.0587 0.0069 363 N N1.0 50 124 0.1064 0.007 174 N N5.6 50.1 111.9 0.0914 0.0404 162 N6.0 654.3 1727.7 0.0398 0.0033 2382 N N0.0 161.9 402.1 0.057 0 564 N N6.2 50.8 165.2 0.0638 0.0368 216 N2.1 103.6 448.4 0.032 0.0071 552 N N

15.3 811.8 1915.2 0.0432 0.0071 2727 A N5.1 400.3 1102.7 0.0441 0.0043 1503 N N2.0 133.4 397.6 0.0542 0.0048 531 N N3.0 228.4 608.6 0.0517 0.0046 837 N N

12.4 510.6 1190.4 0.0449 0.0092 1701 N N

2.0 262.6 613.4 0.0506 0.003 876 N N4.1 332.3 921.7 0.0442 0.0041 1254 N N4.1 587.4 1245.6 0.0455 0.0029 1833 N N2.0 403.6 1177.4 0.0421 0.0016 1581 N N1.0 105.8 245.2 0.0673 0.0037 351 N N5.1 232.1 532.9 0.0549 0.0085 765 N N

31.6 901.1 2080.9 0.0398 0.0135 2982 N N3.0 233.3 669.7 0.0479 0.0042 903 N N3.0 169.1 475.9 0.0523 0.0059 645 N N6.2 410.3 1014.7 0.046 0.0054 1425 N N1.1 169.9 421.1 0.0492 0.0023 591 N N4.0 484 1385 0.0366 0.0028 1869 N N0.0 484.1 1327.9 0.0372 0 1812 N N3.1 235.9 508.1 0.058 0.0052 744 N N4.0 447.7 1121.3 0.0408 0.0034 1569 N Y0.0 109.3 313.7 0.0569 0 423 N N1.0 270.6 686.4 0.045 0.0014 957 N N1.0 270.6 686.4 0.045 0.0014 957 N N2.9 55.2 118.8 0.0692 0.0237 174 N N2.0 171.8 416.2 0.0539 0.0044 588 N N4.1 524.6 1518.4 0.0381 0.0025 2043 N N1.0 172.4 292.6 0.0718 0.0028 465 N N

12.2 601 1505 0.0413 0.0074 2106 N N7.2 205.2 568.8 0.0489 0.0117 774 N N1.0 141.2 533.8 0.0423 0.0019 675 N N2.0 205.4 511.6 0.048 0.0037 717 N N3.0 379.2 1261.8 0.0349 0.0023 1641 N N2.0 274.7 766.3 0.0445 0.0025 1041 N N5.1 417.4 1298.6 0.0391 0.0037 1716 N N3.0 83.4 255.6 0.0614 0.0111 339 N N4.0 175 536 0.0452 0.0073 711 N N4.1 241.6 667.4 0.0439 0.0058 909 N N0.0 175.2 613.8 0.0416 0 789 N N3.0 84 297 0.0506 0.0101 381 N N1.0 84.1 299.9 0.0524 0.0033 384 N N4.1 383 724 0.0536 0.0047 1107 N N0.0 419.7 1059.3 0.042 0 1479 N N7.1 493.9 1168.1 0.046 0.0054 1662 N N0.0 176 487 0.0519 0 663 N N5.0 384.7 968.3 0.0467 0.0047 1353 N N0.0 278.3 732.7 0.0459 0 1011 N N6.2 885.1 2210.9 0.0363 0.0025 3096 N N1.0 146 499 0.0467 0.002 645 N N2.0 279.9 809.1 0.0437 0.0023 1089 N N5.0 729 2256 0.0344 0.0021 2985 N N2.0 86.8 339.2 0.0502 0.0058 426 N N6.1 539.5 1440.5 0.0361 0.0039 1980 N N0.0 87.6 149.4 0.0798 0 237 N N5.1 428.8 903.2 0.0444 0.005 1332 N N5.1 355.6 751.4 0.0539 0.0057 1107 N N8.3 35.4 120.6 0.0582 0.0696 156 N N1.0 181.7 508.3 0.0436 0.0019 690 N N1.0 118 314 0.0532 0.003 432 N N

1.0 60.5 236.5 0.0454 0.0044 297 N N6.0 215.9 633.1 0.0431 0.0092 849 N N1.0 149.9 351.1 0.0585 0.0025 501 N N4.0 506.7 1647.3 0.0325 0.0024 2154 N N2.0 251.3 750.7 0.0392 0.0026 1002 N N0.0 150.8 332.2 0.0544 0 483 N N0.0 322.4 739.6 0.0505 0 1062 N N0.0 61.4 196.6 0.0477 0 258 N N7.1 546.3 1112.7 0.0412 0.0056 1659 N N8.2 432.9 1028.1 0.0437 0.0071 1461 N N1.0 396.6 1040.4 0.0405 0.0009 1437 N N3.0 218.3 705.7 0.0398 0.0042 924 N N2.0 288.2 1163.8 0.0342 0.0017 1452 N N6.2 253.3 601.7 0.0496 0.009 855 N N2.1 219.8 503.2 0.0509 0.0036 723 N N2.1 91 338 0.0325 0.0079 429 N N0.0 15.8 20.2 0.1553 0 36 N1.0 186.9 407.1 0.049 0.0022 594 N4.1 475.6 1132.4 0.038 0.0033 1608 N N6.1 154.3 664.7 0.0305 0.0098 819 N Y1.0 364.3 1126.7 0.0376 0.0009 1491 N N1.0 154.9 427.1 0.0434 0.0023 582 N N3.0 365.5 948.5 0.0429 0.0029 1314 N N5.0 222.9 686.1 0.039 0.0072 909 N N2.0 293.9 876.1 0.0394 0.0022 1170 N N5.1 673.8 1756.2 0.0395 0.0026 2430 N N7.1 294.6 845.4 0.043 0.0078 1140 N N7.1 124.4 403.6 0.0425 0.0174 528 N N

10.4 753.9 1646.1 0.0443 0.0053 2400 N N6.2 635.9 1818.1 0.0345 0.0032 2454 N N4.1 295.5 799.5 0.0419 0.0047 1095 N N

11.2 369 966 0.0424 0.0106 1335 A N5.2 332.3 744.7 0.0471 0.006 1077 N N2.0 190.8 523.2 0.0477 0.0036 714 N N

12.5 716.2 1689.8 0.0362 0.0068 2406 N N8.0 676.7 1951.3 0.0327 0.0039 2628 N N0.0 296.8 804.2 0.0409 0 1101 N N4.0 521.8 1218.2 0.0404 0.003 1740 N N4.1 191.7 393.3 0.053 0.009 585 N N2.0 370.5 910.5 0.0421 0.002 1281 N Y2.0 561.8 1820.2 0.0312 0.0011 2382 N N1.1 95.4 216.6 0.0571 0.0042 312 N N5.0 640.6 1666.4 0.0383 0.0028 2307 N Y3.2 410.1 792.9 0.0485 0.0032 1203 N N2.0 228.5 734.5 0.037 0.0027 963 N N4.0 411.1 1124.9 0.0375 0.0034 1536 N N7.2 604.1 1498.9 0.0381 0.0043 2103 N N0.0 194.3 669.7 0.037 0 864 N N1.0 40.4 166.6 0.0562 0.0059 207 N N2.0 194.9 552.1 0.0434 0.0034 747 N N6.1 527.9 1785.1 0.0301 0.0034 2313 N N2.0 97.2 298.8 0.0452 0.0066 396 N N6.0 161.4 486.6 0.049 0.0116 648 N N

8.1 161.6 471.4 0.0472 0.0161 633 N0.0 129 300 0.0528 0 429 N N0.0 302.3 840.7 0.0392 0 1143 N N6.2 196 485 0.0476 0.0114 681 N N8.1 687.6 1610.4 0.0385 0.0045 2298 N N0.0 196.7 730.3 0.0337 0 927 N N0.0 68.5 225.5 0.0443 0 294 N N0.0 531.7 1565.3 0.0345 0 2097 N N2.0 69 213 0.048 0.0093 282 N N1.0 98.9 312.1 0.0438 0.0032 411 N N4.1 268.5 886.5 0.0384 0.0044 1155 N N0.0 130.7 349.3 0.0482 0 480 N N0.0 18.6 41.4 0.1022 0 60 N N8.0 233.9 840.1 0.0344 0.0096 1074 N N2.1 132.5 290.5 0.0559 0.0061 423 N N3.0 421 1148 0.0395 0.0024 1569 N N2.1 100.8 286.2 0.0497 0.0066 387 N N0.0 133.1 412.9 0.0424 0 546 N N6.0 657 1704 0.0383 0.0032 2361 N N6.1 462.6 1265.4 0.0362 0.0045 1728 N N3.1 134.6 297.4 0.0501 0.0092 432 N N4.1 203 538 0.0466 0.0069 741 N N7.0 203.5 603.5 0.0407 0.0112 807 N Y2.9 239.1 864.9 0.0346 0.0035 1104 N N0.0 169.4 481.6 0.0449 0 651 N N0.0 169.5 475.5 0.0449 0 645 N N0.0 240 972 0.0276 0 1212 N N0.0 135.9 383.1 0.045 0 519 N N1.0 388.7 1048.3 0.0392 0.0009 1437 N N1.0 276.8 860.2 0.0332 0.0012 1137 N Y2.0 240.6 626.4 0.0416 0.003 867 N N5.1 466.3 982.7 0.045 0.0044 1449 N N5.0 427.7 1117.3 0.0395 0.0042 1545 N N1.0 44.8 126.2 0.0517 0.0077 171 N2.1 351.7 977.3 0.0381 0.0019 1329 N N3.0 170.6 663.4 0.0338 0.0046 834 N N1.1 205.7 556.3 0.0396 0.0017 762 N N0.0 206 655 0.0392 0 861 N N4.0 353 763 0.0447 0.0047 1116 N N3.0 242.3 732.7 0.0344 0.0041 975 N N0.0 468.8 1103.2 0.0396 0 1572 N N2.0 137.9 543.1 0.036 0.0037 681 N N2.0 137.9 375.1 0.0422 0.0051 513 N Y1.0 105.2 467.8 0.033 0.0022 573 N N0.0 45.7 272.3 0.0306 0 318 N N9.2 470.3 972.7 0.0445 0.0081 1443 N N0.0 138.7 479.3 0.0379 0 618 N N

12.2 394.4 1381.6 0.0325 0.0086 1776 N N0.0 433.1 967.9 0.0408 0 1401 N N7.1 472.1 1009.9 0.0426 0.0061 1482 N N6.0 916 2324 0.0365 0.0024 3240 N N7.9 394.8 1471.2 0.0312 0.0054 1866 N N3.0 244.9 574.1 0.0439 0.0048 819 N N

1.0 209.1 492.9 0.0463 0.0018 702 N N6.0 245.3 720.7 0.0422 0.0078 966 N N2.0 139.9 397.1 0.043 0.0048 537 N N5.9 209.8 738.2 0.0355 0.0081 948 N N0.0 140.6 516.4 0.0355 0 657 N N

10.1 837.3 2150.7 0.0325 0.0044 2988 N N0.0 397.1 922.9 0.0393 0 1320 N N2.0 397.3 856.7 0.0471 0.002 1254 N N4.0 321.2 1010.8 0.0325 0.0039 1332 N N0.0 247 629 0.0412 0 876 N N6.1 397.8 1060.2 0.0409 0.0053 1458 N N2.0 141.1 446.9 0.039 0.0044 588 N4.3 175.8 421.2 0.0515 0.0088 597 N N0.0 76.6 157.4 0.0567 0 234 N N0.0 285 645 0.0433 0 930 N N2.0 176.4 504.6 0.0418 0.0038 681 N N2.1 360.9 821.1 0.0433 0.0022 1182 N Y0.0 176.6 432.4 0.048 0 609 N N8.3 47.8 135.2 0.0493 0.059 183 N N1.0 77.2 390.8 0.0302 0.0027 468 N N

11.4 882.9 2276.1 0.0328 0.0048 3159 N N2.1 286 686 0.0437 0.0026 972 N N0.0 48 204 0.0334 0 252 N N8.1 478.7 1474.3 0.0345 0.0052 1953 N N1.0 286.6 679.4 0.0393 0.0014 966 N N2.0 143 550 0.0343 0.0037 693 N N9.1 679.8 1939.2 0.0327 0.0045 2619 N N1.0 249.9 617.1 0.0455 0.0015 867 N N

24.7 969 2745 0.028 0.0087 3714 N N5.1 520 1046 0.0429 0.0042 1566 N N3.0 110.1 303.9 0.0432 0.0095 414 N N2.0 402.4 1430.6 0.0264 0.0018 1833 N N8.1 640.8 1885.2 0.0334 0.0041 2526 N N4.1 288 711 0.0392 0.0053 999 N N3.1 251 715 0.037 0.004 966 N N4.1 326.1 942.9 0.0372 0.004 1269 N N0.0 78.6 212.4 0.0432 0 291 N N1.0 110.6 354.4 0.0404 0.0028 465 N N6.1 110.6 360.4 0.0389 0.0166 471 N N3.1 179.2 504.8 0.0434 0.0056 684 N N4.2 482 1096 0.0387 0.0033 1578 N Y

27.6 1055.5 2607.5 0.0342 0.0096 3663 N N0.0 49.6 130.4 0.0444 0 180 N N5.1 253.3 715.7 0.0371 0.0067 969 N Y0.0 111.8 260.2 0.0478 0 372 N N1.0 216.6 551.4 0.0412 0.0017 768 N N0.0 809 2032 0.0314 0 2841 N N1.0 79.7 355.3 0.0342 0.0029 435 N N1.0 79.7 286.3 0.0384 0.0035 366 N N1.0 445.3 1012.7 0.0391 0.0009 1458 N N

10.4 485 1069 0.0426 0.0083 1554 N N3.1 146.2 372.8 0.0426 0.0076 519 N N1.0 146.2 462.8 0.0371 0.0021 609 N N

2.1 525.8 1592.2 0.0306 0.0012 2118 N N1.0 80.2 261.8 0.0436 0.0037 342 N N0.0 112.7 214.3 0.0605 0 327 N N2.9 146.7 699.3 0.0279 0.0045 846 N N1.0 407.7 846.3 0.0425 0.001 1254 N Y6.1 447.1 1445.9 0.0321 0.0041 1893 N N5.1 369 966 0.0378 0.0048 1335 N N4.1 408 912 0.0406 0.0039 1320 N N0.0 292.7 1117.3 0.0319 0 1410 N N4.0 218.5 678.5 0.0369 0.0057 897 N N0.0 182.6 441.4 0.0389 0 624 N N2.0 113.4 351.6 0.0403 0.0055 465 N N0.0 50.8 156.2 0.0416 0 207 N N2.0 219.2 773.8 0.031 0.0026 993 N N

28.7 1150.1 3082.9 0.0328 0.0085 4233 N N15.4 528.8 1430.2 0.0338 0.01 1959 N N

7.0 294.2 710.8 0.0404 0.0091 1005 N N0.0 114.1 320.9 0.043 0 435 N N1.0 410.8 897.2 0.0407 0.001 1308 N N2.0 220.3 580.7 0.0377 0.0033 801 N N2.0 148.6 508.4 0.0341 0.004 657 N N8.3 571.1 1429.9 0.0364 0.0055 2001 N N4.1 295.6 709.4 0.0419 0.0051 1005 N N0.0 82.2 271.8 0.0394 0 354 N N0.0 221.2 807.8 0.0314 0 1029 N N0.0 334.4 901.6 0.0352 0 1236 N N0.0 51.7 74.3 0.0781 0 126 N N0.0 296.3 702.7 0.0431 0 999 N N0.0 258.9 482.1 0.0497 0 741 N N1.0 149.9 492.1 0.0359 0.002 642 N N4.0 185.6 588.4 0.036 0.0067 774 N N

11.2 493.2 1204.8 0.0392 0.0083 1698 N N4.1 374.8 867.2 0.0397 0.0042 1242 N N1.0 186 516 0.04 0.0018 702 N N2.1 453.8 1232.2 0.0327 0.0016 1686 N Y0.0 83.2 282.8 0.0371 0 366 N N6.2 222.9 578.1 0.0369 0.01 801 N N6.1 863.6 2667.4 0.0288 0.0022 3531 N N4.1 223.2 601.8 0.0363 0.0064 825 N N1.0 455.3 1107.7 0.0402 0.0008 1563 N N0.0 5 28 0 0 33 N N

12.0 907 2546 0.0329 0.0044 3453 N N2.0 151.4 508.6 0.0376 0.0038 660 N N2.0 151.6 295.4 0.0516 0.0058 447 N N0.0 187.6 445.4 0.0431 0 633 N N0.0 84.1 131.9 0.0678 0 216 N N0.0 152.1 348.9 0.0442 0 501 N N0.0 225.3 797.7 0.0317 0 1023 N N0.0 117.9 335.1 0.0377 0 453 N N1.0 458.1 1080.9 0.0371 0.0008 1539 N N4.1 378.9 989.1 0.0354 0.0038 1368 N N2.1 458.2 1032.8 0.0376 0.0018 1491 N Y4.2 301.4 637.6 0.0498 0.0055 939 N N

0.0 26 205 0.0378 0 231 N N2.0 263.3 927.7 0.0308 0.0022 1191 N N2.0 226.4 484.6 0.044 0.0037 711 N N4.0 459.5 1424.5 0.0306 0.0028 1884 N N4.0 118.7 373.3 0.0401 0.0103 492 N N2.0 85.3 241.7 0.0428 0.0079 327 N N0.0 118.9 412.1 0.0376 0 531 N N2.0 226.9 652.1 0.0387 0.0029 879 N N4.1 227 610 0.0376 0.0062 837 N N1.0 154 440 0.0394 0.0022 594 N N0.0 341.8 900.2 0.0339 0 1242 N Y5.0 541.2 1516.8 0.0348 0.0031 2058 N N6.5 265.2 565.8 0.0467 0.0108 831 N N

16.3 342.8 1124.2 0.0317 0.0141 1467 N N10.1 343.3 838.7 0.0398 0.0109 1182 N N

0.0 86.7 159.3 0.0551 0 246 N N7.1 423.1 1052.9 0.0398 0.006 1476 N N

14.9 876 2568 0.0297 0.0056 3444 N N3.0 229.1 619.9 0.0376 0.0046 849 N N0.0 267 570 0.0421 0 837 N N3.0 267.1 590.9 0.0447 0.0045 858 N N0.0 305.7 621.3 0.0443 0 927 N N2.1 344.9 1098.1 0.0323 0.0018 1443 N N9.4 192.5 419.5 0.0476 0.0189 612 N N1.0 156.5 395.5 0.0445 0.0023 552 N N0.0 230.2 792.8 0.0302 0 1023 N N0.0 87.5 305.5 0.0345 0 393 N N5.1 193.2 436.8 0.042 0.0104 630 N N1.0 87.8 260.2 0.043 0.0036 348 N N6.1 346.4 1120.6 0.0315 0.0053 1467 N N1.0 88.1 388.9 0.0306 0.0027 477 N N1.0 194.4 462.6 0.0434 0.0019 657 N N2.0 122.4 480.6 0.0313 0.0042 603 N N0.0 427.1 1036.9 0.0356 0 1464 N N5.1 630.9 1760.1 0.0316 0.0027 2391 N N7.1 348.1 815.9 0.0375 0.0079 1164 N N1.0 232.2 628.8 0.0363 0.0015 861 N N0.0 232.3 652.7 0.0388 0 885 N N1.0 194.9 519.1 0.0394 0.0018 714 N N0.0 56.8 135.2 0.0457 0 192 N N3.1 388.9 1186.1 0.0315 0.0025 1575 N N0.0 159 519 0.0363 0 678 N N0.0 271.4 742.6 0.0344 0 1014 N N1.0 89.3 216.7 0.0433 0.0043 306 N N

35.7 592.3 1579.7 0.0339 0.021 2172 N N4.0 196.3 622.7 0.0341 0.0063 819 N N1.0 196.4 646.6 0.032 0.0015 843 N N0.0 6.1 32.9 0 0 39 N1.0 89.8 207.2 0.045 0.0044 297 N N0.0 90 165 0.0627 0 255 N N1.0 431.7 1236.3 0.0334 0.0008 1668 N N

16.1 678.1 2009.9 0.0293 0.0077 2688 N N1.0 197.6 423.4 0.0356 0.0022 621 N N

0.0 273.7 638.3 0.0386 0 912 N N0.0 125.4 333.6 0.041 0 459 N N2.0 313.5 778.5 0.0401 0.0023 1092 N N0.0 58.6 277.4 0.0313 0 336 N N0.0 199.5 487.5 0.0396 0 687 N N3.0 91.8 202.2 0.0515 0.0129 294 N N5.0 354.9 1109.1 0.0318 0.0044 1464 N N2.0 315.5 1013.5 0.0284 0.002 1329 N N3.1 276.4 560.6 0.0468 0.0046 837 N N

34.2 852.4 2633.6 0.0291 0.0125 3486 N N2.1 163.3 376.7 0.0398 0.0049 540 N N2.1 163.3 448.7 0.0383 0.0042 612 N Y

13.0 810.2 2327.8 0.0309 0.0053 3138 N N20.5 1196.3 3060.7 0.0326 0.0061 4257 N N

3.0 127.7 385.3 0.0377 0.0075 513 N N3.0 201.3 662.7 0.0309 0.0045 864 N N0.0 127.8 292.2 0.0392 0 420 N N0.0 60 117 0.0491 0 177 N N8.3 1155.5 3596.5 0.0265 0.0023 4752 N N0.0 164.4 399.6 0.0376 0 564 N N

20.5 812.9 2205.1 0.031 0.0086 3018 N N5.0 201.8 761.2 0.0286 0.0067 963 N N

10.2 479.1 1161.9 0.0366 0.0079 1641 N N2.0 202.1 802.9 0.0282 0.0025 1005 N N4.1 279.1 641.9 0.0404 0.0056 921 N N0.0 93.6 491.4 0.0247 0 585 N N2.1 165.2 395.8 0.0421 0.0046 561 N N3.9 772.7 2185.3 0.0317 0.0017 2958 N N0.0 241.1 685.9 0.0329 0 927 N N0.0 241.1 529.9 0.0424 0 771 N N1.0 165.6 404.4 0.0418 0.0022 570 N N4.1 203.2 423.8 0.0411 0.0084 627 N N2.0 241.5 796.5 0.0302 0.0025 1038 N N2.0 319.8 955.2 0.034 0.002 1275 N N

16.1 986.9 2919.1 0.0286 0.0053 3906 N N0.0 359.7 873.3 0.037 0 1233 N N1.0 242.1 645.9 0.0355 0.0015 888 N N0.0 166.5 640.5 0.0274 0 807 N N3.0 166.6 496.4 0.0337 0.0059 663 N N0.0 281.6 696.4 0.0356 0 978 N N5.1 401.5 1008.5 0.0381 0.0045 1410 N N4.3 361.4 1123.6 0.0299 0.0039 1485 N N

12.4 733.9 1654.1 0.0373 0.0065 2388 N N1.0 282.2 566.8 0.0366 0.0016 849 N5.1 130.5 301.5 0.0426 0.0151 432 N N6.1 525.1 1376.9 0.0334 0.0041 1902 N N3.9 167.2 621.8 0.0318 0.0064 789 N N8.2 282.3 680.7 0.0366 0.0109 963 N N0.0 402.9 878.1 0.0377 0 1281 N N2.0 205.5 823.5 0.0259 0.0025 1029 N N3.0 821.6 2160.4 0.0318 0.0013 2982 N N

26.4 1428.4 3254.6 0.0328 0.0072 4683 N N10.3 568.8 1282.2 0.035 0.0071 1851 N Y

0.0 62.4 210.6 0.0306 0 273 N N4.0 486.1 1166.9 0.0379 0.0031 1653 N N7.2 445.3 1234.7 0.0332 0.0054 1680 N N1.0 284.3 600.7 0.0405 0.0015 885 N N2.0 131.9 420.1 0.0341 0.0046 552 N N3.0 245.4 618.6 0.0346 0.0046 864 N6.1 570.1 1685.9 0.0295 0.0035 2256 N N7.3 696.3 1460.7 0.043 0.0041 2157 N N6.2 739.6 1591.4 0.0355 0.0034 2331 N N4.1 285.5 701.5 0.0362 0.0053 987 N N4.1 571.4 1426.6 0.034 0.0026 1998 N N2.0 132.8 467.2 0.029 0.0044 600 N3.1 207.9 416.1 0.0482 0.0061 624 N N6.6 246.8 728.2 0.0318 0.0085 975 N N2.0 247 608 0.0406 0.003 855 N N4.8 208.4 433.6 0.0448 0.0092 642 N N1.9 326.6 1206.4 0.0239 0.0017 1533 N Y2.0 247.4 853.6 0.0296 0.0023 1101 N N3.1 133.5 310.5 0.037 0.0091 444 N N4.0 286.9 808.1 0.0356 0.0046 1095 N N4.1 133.6 409.4 0.0339 0.0095 543 N N0.0 209 637 0.0289 0 846 N N4.1 247.9 643.1 0.0327 0.006 891 N N2.1 248.1 684.9 0.0348 0.0028 933 N N1.0 98.2 378.8 0.0298 0.0027 477 N N0.0 64.2 211.8 0.0317 0 276 N N3.1 64.5 169.5 0.0376 0.0169 234 N4.0 328.9 889.1 0.0331 0.0043 1218 N N0.0 134.9 468.1 0.0315 0 603 N N7.2 788.2 2247.8 0.0299 0.003 3036 N N1.0 172.5 499.5 0.0319 0.002 672 N N0.0 370.1 1072.9 0.0299 0 1443 N N0.0 99.2 182.8 0.0511 0 282 N N2.0 211 1019 0.0262 0.0021 1230 N N1.0 289.6 970.4 0.0294 0.001 1260 N N4.1 289.6 901.4 0.0299 0.0044 1191 N N9.3 535.6 1429.4 0.0317 0.006 1965 N N2.1 250.4 613.6 0.0353 0.003 864 N N3.0 135.7 338.3 0.0365 0.0083 474 N N2.0 33.7 110.3 0.031 0.0182 144 N2.0 412.4 1183.6 0.0324 0.0016 1596 N N0.0 173.8 456.2 0.0345 0 630 N N0.0 291.1 632.9 0.0377 0 924 N N7.3 173.9 378.1 0.0404 0.0167 552 N4.0 136.4 358.6 0.0368 0.0105 495 N N5.0 495.8 1328.2 0.0351 0.0035 1824 N N6.0 454.6 1162.4 0.0344 0.0048 1617 N N4.0 372.5 1031.5 0.0323 0.0037 1404 N N6.1 580.7 1303.3 0.0349 0.0042 1884 N N

11.2 414.4 1094.6 0.0342 0.0094 1509 N N0.0 137.4 267.6 0.0363 0 405 N N2.0 101 421 0.0268 0.0049 522 N N3.0 175.4 340.6 0.0474 0.0074 516 N N

9.1 1098.8 2516.2 0.031 0.0033 3615 N N0.0 175.5 496.5 0.0345 0 672 N N1.0 101.3 294.7 0.0377 0.0032 396 N

12.2 456.9 1082.1 0.0354 0.0101 1539 N N0.0 333.9 767.1 0.0356 0 1101 N N9.1 293.6 744.4 0.0353 0.0112 1038 N Y2.0 175.9 910.1 0.0213 0.0024 1086 N N2.1 541.3 1144.7 0.0369 0.0015 1686 N N2.0 66.8 230.2 0.0311 0.0087 297 N N1.0 34.8 145.2 0.0245 0.0073 180 N N4.1 214.9 517.1 0.0368 0.0071 732 N N7.1 458 880 0.0438 0.0067 1338 N N2.1 254.4 708.6 0.0336 0.0027 963 N N3.1 883.8 2203.2 0.035 0.0012 3087 N N0.0 34.9 73.1 0.0367 0 108 N4.0 138.7 467.3 0.0309 0.0085 606 N N1.0 215.4 414.6 0.0443 0.002 630 N N0.0 139 242 0.052 0 381 N N3.0 627.8 2171.2 0.0237 0.0014 2799 N N3.0 177.3 482.7 0.0349 0.0059 660 N N0.0 8.8 30.2 0 0 39 N4.1 216.3 698.7 0.0291 0.0057 915 N N1.0 501.9 1235.1 0.0329 0.0008 1737 N Y2.0 178.1 559.9 0.0303 0.0035 738 N N0.0 140.1 408.9 0.033 0 549 N N5.0 337.4 1039.6 0.03 0.0047 1377 N N5.0 461.6 1416.4 0.0296 0.0034 1878 N N

10.2 217.8 604.2 0.0314 0.0161 822 N N3.0 297.7 893.3 0.0286 0.0033 1191 N N3.1 462.5 1271.5 0.0318 0.0022 1734 N N1.0 297.8 731.2 0.0361 0.0012 1029 N N3.9 420.9 1559.1 0.0221 0.0026 1980 N N

12.1 1240.2 3370.8 0.0283 0.0034 4611 N N1.0 218.2 510.8 0.0374 0.0018 729 N N4.0 890.3 2376.7 0.0297 0.0016 3267 N N0.0 179.6 630.4 0.0297 0 810 N N0.0 68.9 231.1 0.0289 0 300 N N1.0 36.2 152.8 0.026 0.0067 189 N0.0 339.5 776.5 0.037 0 1116 N N6.0 218.8 600.2 0.0348 0.0094 819 N N7.2 179.8 519.2 0.0331 0.013 699 N N3.2 633.3 1796.7 0.0296 0.0019 2430 N N2.0 340.5 847.5 0.0354 0.0022 1188 N N2.0 299.8 1107.2 0.0261 0.0018 1407 N N

13.4 341 805 0.0368 0.0147 1146 N1.0 220 503 0.0369 0.0018 723 N N9.3 423.8 1187.2 0.0299 0.0073 1611 N N4.0 465.9 1151.1 0.0328 0.0032 1617 N N6.1 636 1689 0.0314 0.0033 2325 N N3.0 383 1264 0.0286 0.0023 1647 N N2.0 105.6 353.4 0.0284 0.0057 459 N N1.0 143.1 417.9 0.0305 0.0023 561 N N1.0 37 164 0.0245 0.0063 201 N

2.1 301.4 1090.6 0.0245 0.0019 1392 N N4.0 221.1 678.9 0.0322 0.0057 900 N N4.1 143.5 438.5 0.0379 0.009 582 N N3.0 261.5 671.5 0.0326 0.0042 933 N N0.0 221.6 648.4 0.0318 0 870 N N5.0 221.7 615.3 0.0337 0.0077 837 N N3.1 510.3 1298.7 0.0344 0.0021 1809 N N0.0 468.4 1112.6 0.033 0 1581 N Y8.0 343.7 916.3 0.0368 0.008 1260 N N1.0 343.9 1120.1 0.029 0.0009 1464 N N4.1 427 1145 0.0327 0.0033 1572 N N2.9 427.2 1339.8 0.0292 0.0022 1767 N N0.0 37.6 55.4 0.0461 0 93 N0.0 222.6 611.4 0.0327 0 834 N N6.0 183.3 632.7 0.0292 0.0094 816 N N1.0 107.1 219.9 0.0451 0.0039 327 N N2.0 222.9 617.1 0.0305 0.0031 840 N N2.0 344.9 879.1 0.0327 0.0021 1224 N N8.2 386.5 1431.5 0.0223 0.0059 1818 N N1.1 71.4 123.6 0.0504 0.0065 195 N6.1 223.4 694.6 0.0266 0.0088 918 N N2.0 387.1 1328.9 0.0268 0.0015 1716 N N3.1 304.6 787.4 0.0344 0.0035 1092 N N1.2 38.1 171.9 0.0316 0.0093 210 N N3.0 346.2 706.8 0.033 0.0039 1053 N N2.1 145.7 337.3 0.0412 0.0052 483 N N9.1 642.3 1547.7 0.032 0.0054 2190 N N1.0 224.2 549.8 0.0352 0.0017 774 N N4.1 264.5 614.5 0.0353 0.0059 879 N N0.0 38.3 90.7 0.0328 0 129 N2.0 305.5 846.5 0.0309 0.0023 1152 N N7.1 515.2 1413.8 0.0343 0.0046 1929 N N0.0 38.5 90.5 0.0371 0 129 N N0.0 38.5 90.5 0.0371 0 129 N N6.1 146.5 429.5 0.0326 0.0134 576 N0.0 185.6 456.4 0.035 0 642 N N1.0 266.2 843.8 0.0288 0.0012 1110 N N3.0 266.3 792.7 0.03 0.0037 1059 N N1.0 147.3 395.7 0.0336 0.0024 543 N N2.0 186.4 704.6 0.028 0.0028 891 N N4.1 109.4 244.6 0.0408 0.0145 354 N

12.1 517.6 1492.4 0.0304 0.0077 2010 N Y0.0 186.6 350.4 0.0553 0 537 N N1.0 186.8 521.2 0.0355 0.0018 708 N N3.0 226.8 655.2 0.0306 0.0044 882 N N1.0 187.1 655.9 0.0279 0.0015 843 N N4.0 308.5 891.5 0.032 0.0042 1200 N N2.0 777.8 2261.2 0.0275 0.0009 3039 N N2.0 187.4 673.6 0.0295 0.0029 861 N N2.0 392.4 792.6 0.0378 0.0022 1185 N N

12.1 691.7 1921.3 0.0313 0.0059 2613 N N6.3 110.4 294.6 0.033 0.0195 405 N N2.1 309.4 665.6 0.0364 0.0027 975 N N

2.0 39.6 161.4 0.0225 0.0129 201 N1.0 188 517 0.0348 0.0018 705 N N1.0 148.8 304.2 0.0418 0.0028 453 N N1.0 477.7 1163.3 0.0328 0.0008 1641 N N3.1 269 718 0.0328 0.0039 987 N N0.0 228.4 449.6 0.0395 0 678 N N9.2 351.9 1046.1 0.0297 0.0083 1398 N N0.0 39.9 167.1 0.0214 0 207 N N1.0 39.9 161.1 0.0248 0.0063 201 N2.1 564.4 1079.6 0.04 0.0016 1644 N N2.0 188.9 522.1 0.0343 0.0036 711 N N5.1 269.8 666.2 0.0325 0.007 936 N N3.1 394.6 1177.4 0.0277 0.0025 1572 N N0.0 189.4 527.6 0.0328 0 717 N N2.0 311.8 1035.2 0.0263 0.0019 1347 N N6.1 523.1 1225.9 0.035 0.0044 1749 N N5.1 150.4 407.6 0.0318 0.0117 558 N N0.0 395.8 912.2 0.0347 0 1308 N N6.0 396 1419 0.025 0.0043 1815 N N3.0 312.4 710.6 0.0406 0.0037 1023 N N5.2 354.3 650.7 0.0442 0.0063 1005 N N3.0 190.4 742.6 0.0234 0.0042 933 N N2.0 151.2 403.8 0.0349 0.0046 555 N N3.1 190.9 505.1 0.0318 0.0056 696 N N0.0 75.7 167.3 0.0347 0 243 N N0.9 191.1 948.9 0.0204 0.0011 1140 N N0.0 272.4 648.6 0.0337 0 921 N N5.1 397.7 877.3 0.0359 0.0051 1275 N N2.0 231.9 650.1 0.0317 0.0029 882 N N1.0 191.7 393.3 0.0359 0.0023 585 N N0.0 192 513 0.0314 0 705 N N1.0 113.6 315.4 0.0319 0.003 429 N N8.0 232.5 769.5 0.0279 0.0103 1002 N N1.0 76.5 301.5 0.0223 0.0035 378 N N0.0 153 483 0.0301 0 636 N N

21.5 614.7 1890.3 0.0269 0.0111 2505 N N1.0 192.9 665.1 0.0284 0.0015 858 N N4.0 193.1 523.9 0.0322 0.0072 717 N N2.0 77 181 0.0319 0.0104 258 N N7.2 317.1 843.9 0.0327 0.0077 1161 N N0.0 193.8 628.2 0.03 0 822 N N0.0 154 449 0.0303 0 603 N N1.0 234.6 656.4 0.029 0.0015 891 N N2.1 359.5 861.5 0.0302 0.0022 1221 N N4.0 317.6 1164.4 0.0246 0.0035 1482 N N1.0 154.2 415.8 0.0283 0.0024 570 N N1.0 115.3 343.7 0.0298 0.0028 459 N N6.5 402.6 941.4 0.0329 0.0062 1344 N N9.1 488.3 1344.7 0.0298 0.0064 1833 N N0.0 78 264 0.0266 0 342 N N1.0 195.3 854.7 0.0208 0.0012 1050 N N

23.5 751.1 1993.9 0.0299 0.0109 2745 N N6.0 490.2 1051.8 0.0351 0.0051 1542 N N

11.1 404.6 1167.4 0.0304 0.009 1572 N N0.0 12.3 68.7 0 0 81 N4.1 621.1 1475.9 0.0368 0.0024 2097 N N2.1 116.9 375.1 0.0368 0.0053 492 N N2.0 278.8 747.2 0.0284 0.0026 1026 N N3.2 577.9 1261.1 0.0352 0.0021 1839 N N5.9 320.9 825.1 0.0313 0.0068 1146 N N2.0 156.5 509.5 0.0274 0.0039 666 N N2.0 156.6 377.4 0.0345 0.0048 534 N N1.0 363.8 992.2 0.0304 0.0009 1356 N N1.0 238.2 472.8 0.0388 0.0018 711 N N5.0 321.7 1043.3 0.0297 0.0046 1365 N N5.1 321.8 974.2 0.0284 0.005 1296 N N

16.2 536.2 1449.8 0.0304 0.0104 1986 N N5.2 407.2 1053.8 0.0297 0.0045 1461 N N3.0 197.7 624.3 0.0288 0.0047 822 N N2.0 157.4 343.6 0.0381 0.0051 501 N N8.1 197.9 675.1 0.0254 0.012 873 N N

11.1 322.6 871.4 0.0318 0.0118 1194 N N3.0 624.4 1499.6 0.0298 0.0019 2124 N N1.0 44 67 0.036 0.0122 111 N4.0 494.3 1389.7 0.0306 0.0027 1884 N N4.1 281.1 630.9 0.0351 0.0057 912 N N2.0 323.3 1185.7 0.0262 0.0017 1509 N N4.1 365.9 969.1 0.0322 0.0038 1335 N N0.0 44.3 210.7 0.0176 0 255 N N6.1 366.2 1085.8 0.0261 0.0055 1452 N N2.0 118.8 349.2 0.0306 0.0055 468 N N4.2 80.5 276.5 0.041 0.0143 357 N N8.1 324 852 0.032 0.0087 1176 N N2.0 324 702 0.0363 0.0025 1026 N N7.0 409.2 1249.8 0.0272 0.0055 1659 N N3.1 282 618 0.0324 0.0044 900 N N2.1 626.6 1488.4 0.0313 0.0012 2115 N N0.0 119.2 345.8 0.0276 0 465 N N5.1 452.9 1080.1 0.0314 0.0043 1533 N N2.0 199.7 463.3 0.0342 0.0039 663 N N3.0 81 171 0.0348 0.0157 252 N N1.1 159.2 425.8 0.0379 0.0022 585 N N0.0 159.3 290.7 0.0559 0 450 N N2.0 159.4 500.6 0.0287 0.0039 660 N N5.1 410.7 960.3 0.0351 0.0046 1371 N N0.0 241.4 505.6 0.0366 0 747 N N4.0 119.8 546.2 0.0219 0.0076 666 N N2.0 159.8 383.2 0.0347 0.0047 543 N N6.2 498 1155 0.0321 0.0047 1653 N N5.0 326.1 933.9 0.029 0.0051 1260 N N

14.6 850.4 1966.6 0.0319 0.0065 2817 N N0.0 13.3 22.7 0 0 36 N1.9 45.2 188.8 0.0206 0.0109 234 N N0.0 81.7 266.3 0.025 0 348 N N

11.3 201 543 0.031 0.0192 744 N0.0 201 393 0.0362 0 594 N N

1.0 284.4 618.6 0.0331 0.0015 903 N N1.0 160.4 406.6 0.0329 0.0023 567 N N0.0 326.8 774.2 0.0341 0 1101 N N4.0 82 284 0.0248 0.0142 366 N N1.0 45.5 119.5 0.0251 0.0081 165 N N4.1 413.2 1191.8 0.0297 0.0032 1605 N N

18.4 986.6 2334.4 0.0311 0.0071 3321 N N1.0 161 472 0.0285 0.002 633 N N3.9 370.5 1309.5 0.0249 0.0031 1680 N N3.1 500.2 1293.8 0.0293 0.0022 1794 N Y3.1 243.5 656.5 0.0298 0.0043 900 N N3.1 285.5 902.5 0.0275 0.0032 1188 N N2.1 243.6 452.4 0.0392 0.0037 696 N N2.9 82.5 187.5 0.0299 0.015 270 N N2.0 328.1 853.9 0.0322 0.0022 1182 N N1.1 82.6 142.4 0.0486 0.0055 225 N2.0 161.7 675.3 0.0229 0.003 837 N N7.2 286.8 613.2 0.0362 0.01 900 N N3.0 458.7 1269.3 0.0276 0.0023 1728 N N0.0 244.9 646.1 0.0295 0 891 N N7.1 415.5 1183.5 0.0276 0.0057 1599 N N1.0 329.6 957.4 0.0277 0.001 1287 N N5.1 415.7 1087.3 0.0299 0.0043 1503 N N3.0 722.8 1668.2 0.0362 0.0016 2391 N N1.0 203.6 660.4 0.0265 0.0015 864 N N3.0 330 984 0.0296 0.0029 1314 N N1.0 245.5 636.5 0.0347 0.0015 882 N N1.0 204 579 0.0287 0.0017 783 N N0.0 204.2 530.8 0.0303 0 735 N N5.0 503.8 1227.2 0.0312 0.0037 1731 N N

11.3 547.6 1381.4 0.0331 0.0074 1929 N N1.0 122.9 303.1 0.0302 0.0031 426 N N1.0 504 1650 0.0249 0.0006 2154 N N2.5 163.3 325.7 0.0436 0.0066 489 N N4.0 163.4 715.6 0.0222 0.0058 879 N N8.1 331.3 805.7 0.0317 0.0092 1137 N N1.0 84.2 308.8 0.0266 0.0032 393 N N1.0 123.4 554.6 0.0219 0.0019 678 N N1.0 205 530 0.03 0.0018 735 N N5.0 289.2 808.8 0.0283 0.0059 1098 N N0.0 205.2 391.8 0.038 0 597 N Y0.0 14.3 48.7 0 0 63 N N5.0 505.9 1327.1 0.029 0.0036 1833 N N7.4 205.8 391.2 0.0387 0.0152 597 N N5.1 638.4 2118.6 0.0263 0.0023 2757 N N0.0 247.7 679.3 0.0277 0 927 N N5.1 594.3 1808.7 0.0254 0.003 2403 N N4.0 639.1 1442.9 0.0334 0.0025 2082 N N8.0 419.7 1029.3 0.0295 0.0073 1449 N N6.2 463.3 976.7 0.0347 0.0054 1440 N N5.9 595.7 2098.3 0.0228 0.0028 2694 N N6.2 47.8 147.2 0.0223 0.0412 195 N N1.8 1043.3 3696.7 0.0227 0.0005 4740 N N

6.3 377.3 774.7 0.0406 0.0067 1152 N N2.0 508.2 1522.8 0.0274 0.0013 2031 N N4.1 165.6 314.4 0.0411 0.0106 480 N N

12.1 596.6 2016.4 0.0258 0.0058 2613 N N0.0 377.8 1158.2 0.0254 0 1536 N N0.0 48.1 227.9 0.0164 0 276 N N5.0 464.9 1224.1 0.0316 0.0038 1689 N N2.9 909.4 2915.6 0.0255 0.001 3825 N N1.0 249.5 506.5 0.0366 0.0017 756 N N4.1 207.5 500.5 0.0284 0.0076 708 N N

25.5 775.1 1978.9 0.029 0.0119 2754 N N0.0 207.6 425.4 0.0355 0 633 N N2.0 86.1 303.9 0.0248 0.0065 390 N N8.0 598.1 1636.9 0.0303 0.0045 2235 N N3.1 250.3 553.7 0.0334 0.0049 804 N N7.1 731.8 1815.2 0.0306 0.0035 2547 N N6.1 422.7 1170.3 0.029 0.0048 1593 N N0.0 208.4 460.6 0.0327 0 669 N N3.0 554.7 1437.3 0.0275 0.002 1992 N Y1.0 250.7 412.3 0.0383 0.002 663 N N3.0 336.3 857.7 0.0302 0.0033 1194 N N4.1 293.4 654.6 0.031 0.0056 948 N N0.0 86.7 423.3 0.0181 0 510 N N3.1 423.6 1232.4 0.0267 0.0024 1656 N Y5.0 1093.3 2929.7 0.0283 0.0016 4023 N N2.0 209 574 0.0297 0.0033 783 N Y8.1 600.3 1469.7 0.0306 0.005 2070 N N8.2 424.2 1051.8 0.0335 0.0069 1476 N N2.0 167.7 501.3 0.0277 0.0038 669 N N2.0 167.9 522.1 0.027 0.0037 690 N N0.0 127 551 0.0217 0 678 N N4.1 209.7 537.3 0.0296 0.007 747 N N1.0 87.2 194.8 0.0312 0.0046 282 N N1.0 49.2 184.8 0.02 0.0055 234 N N1.0 209.9 498.1 0.0293 0.0019 708 N N0.0 338.1 1020.9 0.0271 0 1359 N N2.9 295.1 946.9 0.0268 0.0031 1242 N N0.0 168.3 551.7 0.0268 0 720 N N0.0 210.1 488.9 0.0321 0 699 N N1.0 128 529 0.0201 0.002 657 N N4.0 211 623 0.029 0.0061 834 N N0.0 88 152 0.0432 0 240 N2.0 253.5 751.5 0.0286 0.0025 1005 N N8.4 296.5 714.5 0.0317 0.0111 1011 N N4.1 515 976 0.0362 0.0035 1491 N N3.1 211.4 493.6 0.0332 0.0055 705 N N7.2 253.9 730.1 0.0268 0.0093 984 N2.1 340 794 0.0315 0.0023 1134 N N2.0 783 2523 0.0238 0.0008 3306 N Y2.0 340.2 706.8 0.0358 0.0024 1047 N N4.1 169.7 469.3 0.0262 0.0083 639 N N1.0 128.6 342.4 0.0284 0.0028 471 N N5.0 211.9 613.1 0.0262 0.008 825 N N

5.1 384.1 974.9 0.029 0.0048 1359 N N3.1 88.6 217.4 0.0337 0.0123 306 N N0.0 384.2 758.8 0.0317 0 1143 N N0.0 88.7 283.3 0.0227 0 372 N N2.0 212.2 537.8 0.0316 0.0034 750 N N1.0 212.5 393.5 0.0458 0.0021 606 N N0.0 129.2 482.8 0.0231 0 612 N N5.1 170.6 495.4 0.0289 0.0096 666 N N1.0 170.6 546.4 0.0238 0.0018 717 N N0.0 170.8 243.2 0.0567 0 414 N N0.0 255.5 734.5 0.0264 0 990 N N6.1 341.9 777.1 0.034 0.0069 1119 N N1.1 298.9 880.1 0.026 0.0011 1179 N Y1.9 343.1 1195.9 0.0247 0.0017 1539 N N0.0 130.3 286.7 0.0325 0 417 N N1.0 90 507 0.0159 0.0021 597 N N4.1 475.6 1273.4 0.028 0.003 1749 N N1.0 172.2 448.8 0.0287 0.0021 621 N N2.1 653.9 1590.1 0.0316 0.0011 2244 N Y1.0 214.6 709.4 0.0248 0.0014 924 N N0.0 90.3 185.7 0.036 0 276 N N3.0 387.9 977.1 0.0294 0.0029 1365 N N7.0 476.1 1530.9 0.0258 0.0045 2007 N N7.0 476.1 1530.9 0.0258 0.0045 2007 N N1.0 172.5 310.5 0.043 0.0026 483 N N5.9 520.6 1414.4 0.0276 0.004 1935 N N0.0 214.8 652.2 0.0273 0 867 N N4.0 388.1 1009.9 0.0296 0.0037 1398 N N0.0 257.7 726.3 0.0265 0 984 N N4.0 388.9 1057.1 0.0284 0.0036 1446 N N2.0 90.8 311.2 0.0232 0.0064 402 N N3.0 131.6 345.4 0.0268 0.0083 477 N N8.2 258.6 749.4 0.0265 0.0104 1008 N N6.2 301.9 700.1 0.0298 0.0079 1002 N N1.0 258.8 836.2 0.0252 0.0012 1095 N N1.1 345.8 875.2 0.0308 0.001 1221 N N3.1 173.6 570.4 0.025 0.0052 744 N N9.1 302.3 930.7 0.026 0.0094 1233 N N7.0 434.2 1560.8 0.0227 0.0045 1995 N N1.0 52.3 286.7 0.0148 0.0037 339 N N5.2 259.6 589.4 0.0306 0.0077 849 N N1.0 259.7 748.3 0.03 0.0012 1008 N N2.1 91.6 208.4 0.03 0.0087 300 N N5.0 523.8 1348.2 0.0297 0.0034 1872 N N0.0 216.9 1007.1 0.0179 0 1224 N N

10.1 524 1330 0.0304 0.0069 1854 N N1.0 132.6 524.4 0.0213 0.0019 657 N N2.1 524.1 1368.9 0.0269 0.0014 1893 N N8.1 391.1 1099.9 0.0285 0.0069 1491 N N0.0 174.7 530.3 0.0261 0 705 N N5.0 303.7 818.3 0.0292 0.0057 1122 N N4.1 391.8 883.2 0.033 0.004 1275 N N0.0 217.6 616.4 0.0274 0 834 N N

6.1 569.8 1335.2 0.0289 0.0042 1905 N0.0 52.9 235.1 0.0163 0 288 N N0.0 52.9 79.1 0.0333 0 132 N0.0 217.8 454.2 0.031 0 672 N N6.0 261 795 0.0232 0.0076 1056 N N8.1 481.1 1195.9 0.0317 0.0061 1677 N N3.0 392.7 1251.3 0.0265 0.0023 1644 N N3.0 261.5 875.5 0.0246 0.0034 1137 N N4.1 261.6 518.4 0.0362 0.0066 780 N N3.1 305.5 795.5 0.0269 0.0036 1101 N N3.1 305.5 639.5 0.0349 0.0041 945 N N6.2 979.4 2470.6 0.0282 0.0023 3450 N N1.0 218.9 519.1 0.0318 0.0017 738 N Y0.0 218.9 441.1 0.0351 0 660 N N2.1 262.2 664.8 0.0306 0.0028 927 N N1.0 93.3 266.7 0.0246 0.0036 360 N N0.0 219.5 671.5 0.0246 0 891 N N4.2 262.8 532.2 0.0378 0.0066 795 N N1.0 93.4 278.6 0.0232 0.0035 372 N N0.0 93.5 329.5 0.0218 0 423 N N1.0 219.8 728.2 0.024 0.0014 948 N N1.0 573.4 1421.6 0.0305 0.0006 1995 N N2.0 351 801 0.0307 0.0023 1152 N N3.1 351.3 860.7 0.0294 0.0032 1212 N Y3.1 351.4 857.6 0.0299 0.0032 1209 N N1.0 263.8 738.2 0.0292 0.0013 1002 N N0.0 54.2 236.8 0.0181 0 291 N N2.0 440.3 807.7 0.0366 0.0021 1248 N N4.0 220.7 718.3 0.0241 0.0055 939 N N1.0 220.8 664.2 0.0255 0.0015 885 N N0.0 94.2 493.8 0.0154 0 588 N N1.0 440.8 1596.2 0.022 0.0006 2037 N N9.2 575.7 1296.3 0.0277 0.0065 1872 N N5.1 620.8 1407.2 0.0344 0.0032 2028 N N2.0 486.1 1178.9 0.0284 0.0016 1665 N N2.1 54.8 152.2 0.0268 0.0119 207 N N

10.3 136.4 412.6 0.025 0.0238 549 N N1.0 94.9 307.1 0.0239 0.0032 402 N N1.0 136.5 352.5 0.0281 0.0026 489 N N2.1 265.5 736.5 0.0268 0.0026 1002 N N6.0 712.9 1621.1 0.0333 0.0033 2334 N N1.0 353.8 972.2 0.027 0.001 1326 N N4.0 354.1 1118.9 0.0239 0.0035 1473 N Y3.1 95.3 312.7 0.0208 0.0097 408 N N2.0 222.7 575.3 0.0286 0.0032 798 N N3.9 179.7 918.3 0.0177 0.0046 1098 N N4.1 354.6 947.4 0.0286 0.0039 1302 N N3.0 179.8 597.2 0.0228 0.005 777 N N5.1 223.1 619.9 0.0274 0.0076 843 N N1.0 18.6 77.4 0 0.0134 96 N7.9 444.6 1487.4 0.0256 0.0052 1932 N N0.0 55.7 112.3 0.0292 0 168 N N

25.3 580 1532 0.0289 0.0153 2112 N N

6.0 944.3 2145.7 0.0296 0.0025 3090 N N2.0 311.7 852.3 0.028 0.0022 1164 N N6.1 400.6 1084.4 0.0274 0.0052 1485 N N5.1 180.9 527.1 0.0262 0.0091 708 N N1.0 224.6 570.4 0.0316 0.0016 795 N N0.0 312.7 797.3 0.0289 0 1110 N N3.0 268.7 961.3 0.0226 0.0031 1230 N N2.1 268.8 652.2 0.0337 0.0028 921 N N0.0 56.4 126.6 0.0247 0 183 N2.0 56.4 273.6 0.0137 0.0078 330 N N6.1 582.7 1385.3 0.0313 0.0039 1968 N Y3.0 269.6 753.4 0.0269 0.0038 1023 N N1.0 97.4 322.6 0.0234 0.003 420 N N3.0 358.4 856.6 0.0288 0.0032 1215 N N

16.5 538.3 1246.7 0.0307 0.0116 1785 N N4.3 226.3 463.7 0.0397 0.0075 690 N N5.0 675.1 1730.9 0.0294 0.0027 2406 N Y5.3 403.8 1063.2 0.0239 0.005 1467 N N1.0 183 645 0.024 0.0015 828 N N0.0 183 345 0.0348 0 528 N N1.0 359.7 1104.3 0.0249 0.0009 1464 N N2.1 449.5 1386.5 0.0229 0.0014 1836 N N2.0 140.4 639.6 0.0171 0.0033 780 N N2.1 360 762 0.0331 0.0023 1122 N N4.0 227.3 768.7 0.0231 0.0052 996 N N1.1 227.5 585.5 0.0326 0.0016 813 N N1.0 360.5 944.5 0.0298 0.001 1305 N N1.0 140.8 405.2 0.0259 0.0023 546 N N0.0 586.2 1723.8 0.0254 0 2310 N N2.0 271.7 868.3 0.0214 0.0023 1140 N N0.0 19.7 46.3 0 0 66 N2.1 184.3 442.7 0.0358 0.0041 627 N N0.0 19.8 61.2 0 0 81 N4.0 272.3 600.7 0.0315 0.0059 873 N N1.0 272.4 738.6 0.0286 0.0013 1011 N0.0 361.5 721.5 0.031 0 1083 N N1.0 272.6 720.4 0.0257 0.0013 993 N Y0.0 272.6 882.4 0.0223 0 1155 N Y0.0 99.1 602.9 0.0145 0 702 N N3.2 496.9 1132.1 0.0305 0.0024 1629 N N3.1 228.6 557.4 0.0353 0.0049 786 N N

17.5 816.3 1943.7 0.0294 0.008 2760 N N13.3 542.4 1461.6 0.0282 0.0083 2004 N N16.3 588 1224 0.0313 0.0116 1812 N N

3.2 407 1375 0.0256 0.0022 1782 N Y0.0 20 79 0 0 99 N N5.1 141.8 431.2 0.0233 0.0114 573 N N0.0 185.1 861.9 0.0164 0 1047 N N0.0 58.2 103.8 0.0306 0 162 N N1.0 99.4 350.6 0.0218 0.0028 450 N N9.0 634.1 1807.9 0.0248 0.0048 2442 N N7.3 452.5 1026.5 0.0331 0.0062 1479 N N2.0 1232.9 3330.1 0.0279 0.0006 4563 N N

1.0 362.8 828.2 0.0301 0.0011 1191 N N4.1 1233.4 3149.6 0.0285 0.0012 4383 N N0.0 229.5 676.5 0.0255 0 906 N N8.2 544 1262 0.0307 0.0057 1806 N N0.0 99.9 320.1 0.021 0 420 N N0.0 100 194 0.0348 0 294 N N2.0 318.9 785.1 0.0281 0.0024 1104 N N3.0 274.5 760.5 0.0253 0.0038 1035 N N0.0 58.9 115.1 0.0444 0 174 N N2.1 274.7 610.3 0.0301 0.0029 885 N N1.1 20.5 48.5 0 0.0202 69 N0.0 20.5 105.5 0 0 126 N0.0 319.9 805.1 0.0287 0 1125 N N0.0 100.7 421.3 0.0174 0 522 N N0.0 187.2 388.8 0.0297 0 576 N N1.0 100.9 292.1 0.0227 0.0033 393 N N1.0 501 1644 0.0224 0.0006 2145 N N0.0 501 1215 0.0277 0 1716 N Y1.0 231.3 449.7 0.0338 0.0019 681 N N6.1 320.5 861.5 0.0268 0.0066 1182 N N0.0 101 523 0.0163 0 624 N N

13.6 638.1 1578.9 0.0306 0.0076 2217 N N4.1 546.9 1472.1 0.0272 0.0026 2019 N N0.0 101.1 345.9 0.0193 0 447 N N4.2 276 537 0.0337 0.0064 813 N N5.0 501.5 1388.5 0.0255 0.0035 1890 N N1.1 144 312 0.0298 0.0028 456 N N6.1 638.7 1647.3 0.0278 0.0034 2286 N N3.1 59.6 309.4 0.0119 0.0106 369 N N1.9 144.2 572.8 0.019 0.0036 717 N N3.1 366.2 815.8 0.0303 0.0033 1182 N N8.1 777 1797 0.029 0.0041 2574 N N2.0 547.9 1246.1 0.0305 0.0014 1794 N N5.2 823.2 2062.8 0.0288 0.0022 2886 N N0.0 144.5 431.5 0.0221 0 576 N N6.2 321.8 899.2 0.0263 0.0063 1221 N N4.1 367.1 1024.9 0.0251 0.0038 1392 N N0.0 60.1 125.9 0.0219 0 186 N N8.1 595 1445 0.0279 0.0051 2040 N N3.0 412.9 1126.1 0.0268 0.0025 1539 N N1.0 189 774 0.0198 0.0013 963 N N2.0 189 471 0.0275 0.0039 660 N N0.0 278 598 0.0306 0 876 N N5.0 413.3 1068.7 0.0273 0.0044 1482 N Y2.1 189.3 569.7 0.0227 0.0035 759 N N0.0 102.4 152.6 0.0577 0 255 N N2.1 278.2 762.8 0.0261 0.0025 1041 N N1.0 189.4 734.6 0.0206 0.0014 924 N N3.0 368.4 906.6 0.0306 0.003 1275 N N1.0 189.5 320.5 0.0388 0.0025 510 N N2.0 102.6 353.4 0.0203 0.0056 456 N N0.0 233.9 708.1 0.0244 0 942 N N3.0 233.9 639.1 0.0266 0.0044 873 N N

12.3 873.1 1958.9 0.0307 0.0057 2832 N N11.9 1384.2 3850.8 0.0245 0.003 5235 N N

1.0 102.8 350.2 0.0224 0.0028 453 N N0.0 323.8 879.2 0.0249 0 1203 N N

10.3 234.2 551.8 0.0257 0.0172 786 N N1.0 189.9 608.1 0.0229 0.0016 798 N N3.0 234.3 782.7 0.0218 0.0038 1017 N N1.0 279.1 686.9 0.0262 0.0014 966 N N0.0 324.1 854.9 0.027 0 1179 N N2.0 234.5 668.5 0.0249 0.0029 903 N N3.1 369.7 692.3 0.0333 0.0037 1062 N Y9.2 460.6 967.4 0.0334 0.0081 1428 N N4.0 324.7 1055.3 0.0234 0.0037 1380 N N1.0 324.8 986.2 0.0243 0.001 1311 N N0.0 146.7 270.3 0.0306 0 417 N N1.0 190.8 478.2 0.0269 0.0019 669 N N2.0 146.9 360.1 0.028 0.005 507 N N0.0 235.4 712.6 0.0253 0 948 N N2.1 325.3 826.7 0.0305 0.0023 1152 N Y0.0 147 288 0.0335 0 435 N N0.0 235.5 421.5 0.0354 0 657 N N6.0 325.7 979.3 0.0262 0.0058 1305 N N3.0 191.5 627.5 0.0209 0.0048 819 N N2.1 280.9 595.1 0.0326 0.0029 876 N N3.2 876.9 1985.1 0.0295 0.0014 2862 N N4.1 236.2 711.8 0.0223 0.0056 948 N N3.1 236.3 438.7 0.0356 0.0057 675 N N2.0 61.8 154.2 0.0227 0.0118 216 N3.0 554.3 1419.7 0.0288 0.0019 1974 N N2.0 326.3 969.7 0.0247 0.002 1296 N N5.1 326.4 843.6 0.0242 0.0057 1170 N N2.1 281.3 684.7 0.0251 0.0028 966 N N6.1 371.9 867.1 0.0297 0.0062 1239 N N2.0 192 606 0.0235 0.0032 798 N N

12.2 600.7 1403.3 0.0301 0.0077 2004 N N4.1 372 831 0.0283 0.0044 1203 N N1.0 147.9 365.1 0.0241 0.0026 513 N N0.0 236.7 636.3 0.0238 0 873 N Y1.0 417.7 1037.3 0.0284 0.0009 1455 N N3.0 463.4 1162.6 0.0277 0.0024 1626 N N6.1 236.8 624.2 0.0283 0.0089 861 N N3.1 236.9 699.1 0.0238 0.0042 936 N N

12.2 372.4 1172.6 0.0243 0.01 1545 N N0.9 237 1047 0.019 0.001 1284 N N7.1 648.4 1457.6 0.032 0.0042 2106 N N1.0 327.8 833.2 0.0248 0.0011 1161 N N1.0 237.8 581.2 0.0271 0.0016 819 N N1.9 741.3 1760.7 0.0307 0.001 2502 N N

29.4 880.4 2392.6 0.0272 0.0114 3273 N N2.0 105.2 356.8 0.0207 0.0055 462 N N2.0 373.6 973.4 0.0265 0.0019 1347 N N0.0 148.9 241.1 0.032 0 390 N5.1 556.8 1639.2 0.0247 0.0029 2196 N N

6.4 328.2 613.8 0.0275 0.0088 942 N N6.4 328.2 613.8 0.0275 0.0088 942 N1.0 465.7 1310.3 0.0239 0.0007 1776 N N2.0 193.8 433.2 0.0297 0.0041 627 N N1.0 238.6 538.4 0.0289 0.0017 777 N N0.0 512 1390 0.026 0 1902 N N6.1 420.9 1241.1 0.0236 0.0047 1662 N N3.9 375.2 1400.8 0.0201 0.0029 1776 N N0.0 194.4 540.6 0.0241 0 735 N N0.0 329.8 627.2 0.0378 0 957 N N

10.2 1256.9 3282.1 0.0264 0.0029 4539 N N1.0 513.2 1268.8 0.0283 0.0007 1782 N N0.0 63.4 143.6 0.0409 0 207 N N1.0 284.8 756.2 0.0251 0.0013 1041 N N3.0 284.8 780.2 0.0262 0.0036 1065 N N2.1 513.5 1226.5 0.0285 0.0015 1740 N N0.0 284.9 630.1 0.0279 0 915 N N0.0 63.6 296.4 0.0127 0 360 N N2.0 106.6 376.4 0.0173 0.0055 483 N N0.0 106.7 559.3 0.0132 0 666 N N5.2 195.3 506.7 0.0239 0.0095 702 N N1.1 195.3 353.7 0.0309 0.0024 549 N N3.0 376.6 1042.4 0.0258 0.0027 1419 N N4.1 376.7 922.3 0.0277 0.004 1299 N N3.0 699.5 1385.5 0.0327 0.0019 2085 N N0.0 106.9 289.1 0.0204 0 396 N N

11.1 839.1 2256.9 0.0272 0.0046 3096 N N6.2 286 701 0.0266 0.008 987 N N5.0 240.8 707.2 0.0232 0.0069 948 N N3.0 331.8 838.2 0.0281 0.0033 1170 N N4.1 241.1 565.9 0.028 0.0064 807 N N2.0 286.6 769.4 0.0271 0.0024 1056 N N1.0 196.3 862.7 0.0163 0.0012 1059 N N0.0 107.5 360.5 0.0181 0 468 N N3.0 286.8 826.2 0.0251 0.0035 1113 N N

17.1 840.9 1814.1 0.0308 0.0083 2655 N N2.0 23.5 162.5 0 0.0135 186 N N1.0 241.8 634.2 0.0285 0.0014 876 N N6.2 424.7 1186.3 0.0282 0.0048 1611 N N5.1 655.9 1585.1 0.0295 0.0029 2241 N N0.0 287.5 738.5 0.0262 0 1026 N N1.0 242.1 792.9 0.022 0.0012 1035 N N8.1 563.4 1446.6 0.028 0.0051 2010 N N4.1 563.7 1764.3 0.0245 0.0022 2328 N N7.1 287.9 693.1 0.0288 0.0092 981 N N2.0 108.2 503.8 0.0146 0.0042 612 N N7.1 108.3 392.7 0.02 0.0177 501 N N0.0 288.1 737.9 0.0276 0 1026 N N1.0 610.7 1048.3 0.0401 0.0008 1659 N N1.0 288.4 836.6 0.0239 0.0012 1125 N N2.0 288.5 725.5 0.0252 0.0026 1014 N N1.0 197.9 588.1 0.0223 0.0017 786 N N0.0 153.1 569.9 0.0191 0 723 N N

1.0 153.1 410.9 0.0248 0.0023 564 N N3.0 243.5 548.5 0.026 0.005 792 N N0.0 108.9 218.1 0.043 0 327 N N3.1 289.2 694.8 0.0271 0.004 984 N N6.0 427.1 1303.9 0.0242 0.0044 1731 N Y1.0 427.1 1141.9 0.0261 0.0008 1569 N N

15.5 427.1 1114.9 0.0265 0.0126 1542 N N0.0 198.5 617.5 0.0219 0 816 N N2.1 198.6 467.4 0.027 0.0039 666 N N0.0 198.6 425.4 0.0293 0 624 N N4.1 65.6 276.4 0.0118 0.0157 342 N N5.1 335.3 1137.7 0.0196 0.0045 1473 N N1.0 109.2 319.8 0.0219 0.003 429 N N5.0 381.3 812.7 0.0312 0.0054 1194 N N2.0 198.8 509.2 0.0251 0.0037 708 N N0.0 65.8 327.2 0.0109 0 393 N N

15.1 335.8 957.2 0.0243 0.0151 1293 N N3.0 474.3 971.7 0.0338 0.0026 1446 N N9.2 336.2 710.8 0.0304 0.0112 1047 N N4.0 382.2 895.8 0.0299 0.004 1278 N N1.0 109.7 547.3 0.0143 0.0019 657 N N3.0 199.5 451.5 0.0278 0.006 651 N N3.1 109.9 250.1 0.0253 0.0108 360 N N6.0 614.3 1434.7 0.0297 0.0038 2049 N N2.0 245.1 696.9 0.0238 0.0028 942 N N3.0 154.7 457.3 0.0224 0.0063 612 N N0.0 66.3 134.7 0.0216 0 201 N N1.0 199.9 508.1 0.026 0.0018 708 N N2.1 291.1 683.9 0.0259 0.0027 975 N N3.0 154.8 481.2 0.0218 0.0061 636 N N9.1 337.1 1057.9 0.0257 0.0081 1395 N N1.0 155.2 564.8 0.0211 0.0017 720 N N2.1 337.7 640.3 0.0366 0.0027 978 N N0.0 246 666 0.0251 0 912 N N0.0 110.6 210.4 0.027 0 321 N N9.3 803 2074 0.0286 0.004 2877 N N0.0 155.5 288.5 0.031 0 444 N N0.0 155.7 432.3 0.0218 0 588 N N4.0 384.6 1289.4 0.0217 0.0031 1674 N N5.1 338.6 861.4 0.027 0.0054 1200 N N1.0 67.1 259.9 0.0142 0.0039 327 N N9.1 339 876 0.0271 0.0095 1215 N N2.1 111.3 257.7 0.0231 0.0071 369 N N

10.2 478.1 1375.9 0.0254 0.0069 1854 N N0.0 111.4 239.6 0.0261 0 351 N N1.0 201.7 659.3 0.0208 0.0015 861 N N2.0 432.1 920.9 0.0305 0.0019 1353 N N0.0 293.7 618.3 0.0305 0 912 N N4.1 293.7 675.3 0.028 0.0053 969 N N4.0 339.9 992.1 0.0233 0.0039 1332 N N8.0 433.1 1165.9 0.0271 0.0064 1599 N N3.1 202.6 433.4 0.0297 0.006 636 N N5.1 806.9 1947.1 0.0284 0.0023 2754 N N

6.0 433.3 901.7 0.0266 0.0061 1335 N N4.1 294.6 710.4 0.0275 0.0051 1005 N N1.0 248.6 699.4 0.0226 0.0014 948 N N3.0 202.9 532.1 0.0253 0.0052 735 N N5.0 341 787 0.029 0.0057 1128 N N0.0 203.1 384.9 0.0292 0 588 N N6.1 295 1064 0.0198 0.0057 1359 N N0.9 249 1167 0.017 0.0009 1416 N N2.0 112.6 310.4 0.0226 0.006 423 N N5.1 387.9 1055.1 0.024 0.0045 1443 N N4.1 68.3 264.7 0.0145 0.0153 333 N N1.0 157.9 367.1 0.0273 0.0024 525 N N4.0 249.5 788.5 0.0238 0.0049 1038 N N4.0 203.7 750.3 0.0197 0.0054 954 N N0.0 113.1 528.9 0.0146 0 642 N N1.0 113.1 207.9 0.029 0.004 321 N N7.1 435.2 1178.8 0.0273 0.0055 1614 N N1.0 342.3 827.7 0.0289 0.0011 1170 N N6.1 250 620 0.0256 0.009 870 N N4.0 482.2 1059.8 0.0275 0.0034 1542 N N1.0 158.6 636.4 0.0214 0.0017 795 N N7.3 113.5 315.5 0.0211 0.0213 429 N N3.1 250.5 544.5 0.0339 0.0049 795 N N4.2 482.8 1047.2 0.0286 0.0034 1530 N N1.0 251.2 636.8 0.0257 0.0015 888 N N1.0 69.3 251.7 0.014 0.004 321 N N4.0 297.5 629.5 0.0303 0.0055 927 N N9.0 624.5 1904.5 0.0241 0.0046 2529 N N0.0 114.2 266.8 0.0322 0 381 N N1.1 159.7 269.3 0.0294 0.0031 429 N N0.0 69.5 125.5 0.0211 0 195 N N3.0 252.2 620.8 0.0253 0.0045 873 N N5.1 578.9 1380.1 0.0288 0.0033 1959 N N7.2 672.9 1751.1 0.0249 0.0038 2424 N N8.0 438.5 1082.5 0.026 0.0069 1521 N N0.0 252.4 683.6 0.0232 0 936 N N0.0 26.7 126.3 0 0 153 N N9.1 345.3 713.7 0.0287 0.0112 1059 N N1.0 392.3 993.7 0.0244 0.001 1386 N N4.0 345.8 791.2 0.0271 0.0046 1137 N N1.0 115.1 184.9 0.0313 0.0043 300 N N0.0 345.9 1085.1 0.0209 0 1431 N N7.3 580 1454 0.0272 0.0044 2034 N N0.0 26.9 108.1 0 0 135 N N0.0 253.1 835.9 0.0207 0 1089 N N0.0 115.3 322.7 0.019 0 438 N N8.6 580.4 1060.6 0.0369 0.0063 1641 N N6.4 253.3 532.7 0.0342 0.01 786 N N0.0 207.1 413.9 0.0404 0 621 N N1.0 70.4 205.6 0.0151 0.0048 276 N N8.3 253.5 580.5 0.0222 0.0133 834 N N1.0 70.6 187.4 0.0165 0.0051 258 N N0.0 207.6 614.4 0.0214 0 822 N N

9.2 676 1619 0.0284 0.005 2295 N N2.1 534.9 1145.1 0.032 0.0015 1680 N Y7.0 347.6 1056.4 0.0246 0.0063 1404 N N4.0 488.9 1227.1 0.0258 0.003 1716 N N4.5 71.3 273.7 0.0181 0.0174 345 N N1.0 395.4 918.6 0.029 0.001 1314 N N3.1 162.6 437.4 0.0237 0.0064 600 N N1.0 162.6 290.4 0.0299 0.0029 453 N

17.2 677.8 1560.2 0.0301 0.0097 2238 N N0.0 116.8 264.2 0.0224 0 381 N N2.1 348.8 854.2 0.0309 0.0021 1203 N N0.0 536.6 1446.4 0.0227 0 1983 N N7.1 302.2 975.8 0.0206 0.0072 1278 N Y4.1 209.1 492.9 0.0251 0.0074 702 N N3.2 209.1 450.9 0.0265 0.0059 660 N N0.0 302.3 684.7 0.0256 0 987 N N4.1 442.9 1072.1 0.0263 0.0034 1515 N N1.0 302.4 666.6 0.0278 0.0013 969 N N3.0 209.3 636.7 0.0202 0.0047 846 N Y1.0 302.5 741.5 0.0266 0.0012 1044 N N2.0 117.1 506.9 0.0163 0.004 624 N N5.1 443.3 1143.7 0.0258 0.0041 1587 N N3.1 256.1 757.9 0.0272 0.0038 1014 N N4.2 256.1 562.9 0.0288 0.0063 819 N N6.2 302.8 606.2 0.0301 0.0086 909 N N0.0 302.8 594.2 0.0324 0 897 N N0.0 117.3 269.7 0.0213 0 387 N N3.0 349.7 1063.3 0.0232 0.0027 1413 N N0.0 71.9 96.1 0.0273 0 168 N N1.0 71.9 411.1 0.0114 0.0025 483 N N0.0 71.9 171.1 0.0185 0 243 N N

10.3 679.4 1681.6 0.0263 0.0055 2361 N N0.0 27.9 41.1 0 0 69 N1.0 117.4 203.6 0.0432 0.004 321 N N0.0 209.8 603.2 0.0266 0 813 N N7.1 256.7 667.3 0.0244 0.0098 924 N N2.0 210.2 590.8 0.0222 0.0032 801 N N3.0 256.9 775.1 0.0216 0.0038 1032 N N1.0 303.7 830.3 0.023 0.0012 1134 N N0.0 210.4 677.6 0.0192 0 888 N Y1.0 164 409 0.0226 0.0023 573 N N0.0 257.2 519.8 0.0289 0 777 N N

11.9 445.2 1033.8 0.0295 0.0101 1479 N N0.0 72.5 380.5 0.01 0 453 N N1.1 257.6 492.4 0.025 0.0018 750 N N4.1 164.5 411.5 0.0236 0.009 576 N N0.0 118.3 184.7 0.0311 0 303 N N5.1 492.8 1376.2 0.0252 0.0034 1869 N N

10.2 966.4 2609.6 0.0249 0.0036 3576 N N2.0 587.4 1548.6 0.0248 0.0012 2136 N Y4.0 257.9 615.1 0.0269 0.0059 873 N N1.0 258 792 0.0225 0.0012 1050 N N3.1 258 660 0.0226 0.0043 918 N N

2.0 72.8 200.2 0.0163 0.0095 273 N N4.0 635 1834 0.0241 0.0021 2469 N N

10.0 540.8 1886.2 0.0208 0.0053 2427 N N16.7 635.4 1344.6 0.0323 0.0105 1980 N N

3.1 165.1 302.9 0.0399 0.0083 468 N N0.0 635.7 1455.3 0.0279 0 2091 N N0.0 28.6 136.4 0 0 165 N N0.0 73.2 166.8 0.0201 0 240 N N0.0 212 397 0.0311 0 609 N4.1 305.8 714.2 0.0266 0.0051 1020 N N2.0 352.9 787.1 0.03 0.0022 1140 N N2.1 259.1 664.9 0.0228 0.0029 924 N N6.0 589.3 1492.7 0.0267 0.0037 2082 N N7.0 873.9 2273.1 0.0265 0.0029 3147 N N4.1 306.1 635.9 0.0276 0.0056 942 N N6.1 447.5 1355.5 0.0226 0.0043 1803 N N1.0 165.7 491.3 0.0191 0.002 657 N N8.1 731.6 1650.4 0.0291 0.0043 2382 N N2.1 542.2 1158.8 0.0323 0.0015 1701 N N9.1 684.4 1826.6 0.027 0.0047 2511 N N1.0 165.9 512.1 0.0207 0.0019 678 N N1.0 259.5 697.5 0.0242 0.0013 957 N N0.0 73.6 295.4 0.012 0 369 N N1.0 542.8 1008.2 0.0313 0.0008 1551 N N0.0 73.8 184.2 0.0172 0 258 N N3.1 923.1 2073.9 0.0295 0.0013 2997 N N0.0 307.2 889.8 0.0228 0 1197 N N2.0 354.4 1076.6 0.021 0.0018 1431 N Y4.0 543.7 1532.3 0.0255 0.0024 2076 N N4.0 354.6 836.4 0.027 0.0043 1191 N N4.9 449.1 1410.9 0.022 0.0035 1860 N N0.0 166.7 682.3 0.0174 0 849 N N0.0 214 707 0.0186 0 921 N N1.0 167.2 399.8 0.0259 0.0022 567 N N4.0 308.2 882.8 0.0236 0.0043 1191 N N2.0 214.1 499.9 0.0313 0.0036 714 N N6.1 450.1 1112.9 0.0268 0.0049 1563 N N4.0 214.3 652.7 0.0206 0.006 867 N N0.0 120.8 635.2 0.0127 0 756 N N5.0 592.8 1795.2 0.0237 0.0027 2388 N N0.0 74.6 135.4 0.0414 0 210 N N2.0 167.7 432.3 0.0222 0.0043 600 N N3.0 74.8 285.2 0.0115 0.0111 360 N N6.0 403.7 1282.3 0.0221 0.0046 1686 N N1.0 309.4 695.6 0.0263 0.0013 1005 N N0.0 452.1 1314.9 0.0218 0 1767 N Y

13.0 832.8 2329.2 0.0258 0.0052 3162 N N1.0 121.7 463.3 0.0155 0.0022 585 N N2.1 215.6 489.4 0.0265 0.0036 705 N N

13.1 547.3 1657.7 0.0227 0.0076 2205 N N0.0 215.7 717.3 0.0208 0 933 N N0.0 30 165 0 0 195 N N6.2 357.7 893.3 0.0242 0.0063 1251 N N

11.4 357.8 824.2 0.0269 0.0121 1182 N N6.1 500.4 1335.6 0.0245 0.0042 1836 N N8.0 405.4 1145.6 0.0237 0.0067 1551 N N1.1 169 320 0.0262 0.0027 489 N N1.0 216.1 455.9 0.0334 0.0019 672 N N4.0 358.1 1174.9 0.0233 0.0033 1533 N N1.0 216.3 440.7 0.0263 0.002 657 N N0.0 122.4 318.6 0.0308 0 441 N N1.0 169.4 343.6 0.0277 0.0025 513 N N2.0 406.1 853.9 0.0327 0.002 1260 N N1.0 263.9 765.1 0.0214 0.0013 1029 N N5.1 216.8 620.2 0.0231 0.0076 837 N N1.0 311.8 783.2 0.0242 0.0012 1095 N N2.0 217.1 583.9 0.0238 0.0032 801 N N4.1 169.9 478.1 0.0208 0.008 648 N N2.0 312.2 917.8 0.0221 0.0021 1230 N N5.1 788.9 2199.1 0.0231 0.0022 2988 N N1.0 123.2 221.8 0.0294 0.0036 345 N N4.9 217.6 685.4 0.0216 0.007 903 N N4.0 217.6 643.4 0.0219 0.0059 861 N N5.1 265.1 673.9 0.0241 0.0069 939 N N0.0 30.7 89.3 0 0 120 N4.0 407.9 1008.1 0.0273 0.0036 1416 N N7.1 503.2 1356.8 0.024 0.0049 1860 N N0.0 503.3 1419.7 0.0227 0 1923 N N6.0 551 1459 0.0251 0.0038 2010 N N1.0 170.7 633.3 0.0164 0.0016 804 N N3.0 408.2 1169.8 0.0224 0.0025 1578 N N2.0 265.7 634.3 0.0259 0.0028 900 N N0.0 123.8 470.2 0.0146 0 594 N N0.0 76.9 151.1 0.0383 0 228 N N5.0 218.5 621.5 0.0226 0.0076 840 N N7.3 266.2 669.8 0.0298 0.0096 936 N N2.0 218.7 462.3 0.0287 0.0037 681 N N6.0 361.4 1084.6 0.0226 0.0053 1446 N N0.0 77.1 144.9 0.0192 0 222 N0.0 409.1 976.9 0.0257 0 1386 N N4.0 124.1 412.9 0.0165 0.0097 537 N N3.1 456.9 884.1 0.029 0.0029 1341 N N0.0 77.2 138.8 0.0223 0 216 N N1.0 124.2 376.8 0.0202 0.0025 501 N N2.1 361.7 811.3 0.0263 0.0022 1173 N N4.1 600.4 1454.6 0.0281 0.0025 2055 N N3.9 505 1361 0.0231 0.0028 1866 N Y1.0 314.5 1038.5 0.0216 0.0009 1353 N N1.0 171.9 455.1 0.0214 0.0021 627 N Y2.0 77.6 198.4 0.0153 0.0096 276 N N4.1 362.6 912.4 0.0229 0.0042 1275 N N1.0 172.4 754.6 0.0143 0.0014 927 N N0.0 125.1 240.9 0.0258 0 366 N Y2.9 315.6 1172.4 0.0151 0.0026 1488 N N

13.4 602.8 1410.2 0.025 0.0086 2013 N N0.0 268.1 910.9 0.0187 0 1179 N N

0.0 78.2 158.8 0.0164 0 237 N N10.2 794.9 1932.1 0.0272 0.0047 2727 N N

2.1 651.3 2075.7 0.0222 0.0009 2727 N N1.0 364.2 1090.8 0.0217 0.0009 1455 N N2.2 78.4 182.6 0.0341 0.01 261 N N3.0 412.2 1123.8 0.0251 0.0025 1536 N N2.0 364.7 841.3 0.0271 0.0021 1206 N N0.0 78.6 137.4 0.0218 0 216 N N0.0 269.2 699.8 0.023 0 969 N N5.2 412.8 1096.2 0.0233 0.0043 1509 N N0.9 796.5 1888.5 0.0268 0.0005 2685 N N2.0 221.7 687.3 0.0198 0.0028 909 N N3.9 269.7 1038.3 0.0173 0.004 1308 N N0.0 269.8 873.2 0.0188 0 1143 N Y0.0 174.2 464.8 0.0199 0 639 N N1.0 174.2 671.8 0.016 0.0015 846 N N8.1 222 540 0.0245 0.0136 762 N N2.1 509.8 1035.2 0.0355 0.0016 1545 N N2.0 222.2 668.8 0.0197 0.0029 891 N N0.0 318 843 0.0266 0 1161 N N1.0 222.4 704.6 0.0196 0.0014 927 N N6.0 414.3 1094.7 0.0239 0.0052 1509 N N3.1 174.7 341.3 0.0356 0.0075 516 N N4.1 318.4 845.6 0.0219 0.0045 1164 N N5.1 366.6 902.4 0.0247 0.0051 1269 N N1.0 127.1 310.9 0.0286 0.003 438 N N1.0 174.9 515.1 0.0214 0.0018 690 N N6.1 366.7 932.3 0.0249 0.0059 1299 N N4.2 175 533 0.0242 0.0074 708 N N0.0 222.9 653.1 0.0206 0 876 N N0.0 127.2 430.8 0.017 0 558 N N2.0 175.1 385.9 0.0237 0.0046 561 N N1.0 79.7 136.3 0.0218 0.0059 216 N N1.0 127.4 295.6 0.0205 0.0031 423 N N8.9 223.2 1003.8 0.0163 0.0093 1227 N N0.0 271.2 889.8 0.0187 0 1161 N N0.0 32.7 150.3 0 0 183 N N

14.0 415.3 1432.7 0.0206 0.0097 1848 N N4.1 271.4 661.6 0.0234 0.0056 933 N N2.0 271.5 625.5 0.0246 0.0029 897 N N0.0 559.9 1219.1 0.0269 0 1779 N Y1.0 175.6 460.4 0.0214 0.002 636 N N3.1 560 1279 0.0263 0.0021 1839 N N0.0 271.6 502.4 0.0355 0 774 N N

11.2 560.1 1527.9 0.0233 0.0069 2088 N N4.1 608.4 1638.6 0.0248 0.0023 2247 N N5.0 223.8 805.2 0.0177 0.0063 1029 N N1.0 416.1 930.9 0.0259 0.001 1347 N Y1.1 223.9 457.1 0.0322 0.0019 681 N N0.0 656.8 1383.2 0.0273 0 2040 N N2.0 224.2 804.8 0.0187 0.0025 1029 N N0.0 176.2 342.8 0.0256 0 519 N N8.3 1091 2527 0.0282 0.0028 3618 N N

5.1 465 1065 0.0292 0.0041 1530 N N1.0 80.5 246.5 0.0272 0.004 327 N N2.0 272.6 615.4 0.0248 0.0029 888 N N4.0 80.6 219.4 0.0145 0.0176 300 N N

10.2 658.2 1921.8 0.0224 0.005 2580 N N1.1 272.9 627.1 0.0289 0.0015 900 N N0.0 176.7 402.3 0.0237 0 579 N N2.0 273 819 0.0196 0.0024 1092 N N3.0 369.4 1292.6 0.0191 0.0023 1662 N N7.1 417.7 1268.3 0.022 0.0053 1686 N N0.0 176.9 702.1 0.0169 0 879 N N6.0 225.3 818.7 0.0186 0.0073 1044 N N8.2 81.1 269.9 0.0138 0.0294 351 N N4.2 707.8 1629.2 0.0258 0.0022 2337 N N1.0 33.7 143.3 0 0.0071 177 N N5.0 419 1135 0.0244 0.0041 1554 N N4.0 323 868 0.0212 0.0044 1191 N N1.0 274.9 613.1 0.0256 0.0015 888 N N0.0 130 593 0.0133 0 723 N N2.0 226.7 598.3 0.0219 0.0031 825 N N0.0 34 113 0 0 147 N N

14.4 226.8 568.2 0.0234 0.0229 795 N N4.0 468.5 1346.5 0.0222 0.0029 1815 N N3.0 82 353 0.0103 0.0089 435 N N

19.4 517.3 1426.7 0.0231 0.0127 1944 N N1.0 324 888 0.0232 0.0011 1212 N N0.0 34.2 163.8 0 0 198 N N1.1 372.6 815.4 0.0269 0.0011 1188 N1.0 469.4 1009.6 0.026 0.0009 1479 N N

11.1 518.2 1443.8 0.0241 0.0072 1962 N N6.0 469.9 1252.1 0.0224 0.0046 1722 N N1.0 131 244 0.0249 0.0034 375 N N1.0 179.5 876.5 0.0132 0.0012 1056 N N3.0 131.1 288.9 0.0222 0.0092 420 N N0.0 34.5 127.5 0 0 162 N N0.0 373.9 682.1 0.0332 0 1056 N N8.1 325.6 880.4 0.0223 0.0086 1206 N N4.0 422.6 1089.4 0.0247 0.0034 1512 N N8.1 616.5 1564.5 0.0249 0.0047 2181 N N2.0 228.7 560.3 0.0232 0.0033 789 N N0.0 568.2 1336.8 0.0245 0 1905 N N3.1 374.6 930.4 0.0265 0.003 1305 N N1.0 520.2 1162.8 0.026 0.0008 1683 N N1.0 180.5 455.5 0.0196 0.0021 636 N N1.1 277.7 658.3 0.024 0.0014 936 N N5.0 326.3 762.7 0.0273 0.0058 1089 N N0.0 229.2 718.8 0.0201 0 948 N N2.0 180.7 575.3 0.0182 0.0034 756 N N

30.3 908.3 2061.7 0.0249 0.0131 2970 N N1.0 472.4 1390.6 0.0219 0.0007 1863 N N5.1 181.1 418.9 0.0205 0.0111 600 N N2.0 230 487 0.0235 0.0037 717 N N6.3 181.4 592.6 0.0183 0.0113 774 N N

1.0 278.8 693.2 0.0222 0.0013 972 N N1.0 376.1 1012.9 0.0264 0.0009 1389 N N4.0 764.5 2325.5 0.0226 0.0017 3090 N N1.0 84 330 0.0113 0.0031 414 N N9.1 376.4 1087.6 0.0226 0.0079 1464 N N1.0 522.2 1127.8 0.0275 0.0008 1650 N N5.1 328 752 0.0243 0.0061 1080 N N0.0 425.6 1125.4 0.0222 0 1551 N N3.0 133.2 475.8 0.0151 0.0063 609 N N5.9 328.4 1186.6 0.0195 0.005 1515 N N5.1 571.7 1633.3 0.0192 0.0036 2205 N N2.0 328.5 808.5 0.0231 0.0023 1137 N N0.0 133.4 388.6 0.0157 0 522 N N0.0 84.6 347.4 0.0095 0 432 N N1.0 231.4 641.6 0.0202 0.0015 873 N N4.1 231.4 506.6 0.0254 0.007 738 N N

13.1 572.6 1662.4 0.0225 0.0075 2235 N N1.0 475.3 862.7 0.0324 0.0009 1338 N N1.0 572.7 1152.3 0.029 0.0008 1725 N N5.2 475.5 1012.5 0.0327 0.0043 1488 N N8.0 1252.8 3211.2 0.0231 0.0026 4464 N N3.3 426.9 1007.1 0.0268 0.0032 1434 N N1.0 524.4 1203.6 0.025 0.0008 1728 N N5.0 183 444 0.0209 0.0105 627 N N2.1 573.3 1475.7 0.0229 0.0013 2049 N Y3.0 183.1 539.9 0.0197 0.0053 723 N2.1 232.1 688.9 0.019 0.0028 921 N Y5.3 281 556 0.0247 0.008 837 N N9.2 768.2 2192.8 0.0246 0.0039 2961 N N8.1 525 1287 0.0264 0.0056 1812 N N1.0 134.3 492.7 0.0145 0.0021 627 N N1.0 134.3 372.7 0.0177 0.0026 507 N N0.0 330.1 1106.9 0.0176 0 1437 N N3.0 281.3 801.7 0.0222 0.0035 1083 N N4.1 671.3 1782.7 0.0236 0.0021 2454 N N1.0 330.2 647.8 0.0302 0.0013 978 N N0.0 36.2 113.8 0 0 150 N N4.2 915.2 1697.8 0.0332 0.002 2613 N N3.1 477.1 1106.9 0.0251 0.0025 1584 N N0.0 134.7 255.3 0.0232 0 390 N N1.0 379.6 838.4 0.0262 0.0011 1218 N N8.1 428.5 1260.5 0.021 0.0062 1689 N N2.0 134.8 318.2 0.0205 0.0057 453 N N4.0 769.7 1891.3 0.0258 0.0019 2661 N N1.0 282 729 0.0208 0.0013 1011 N N1.0 282.1 761.9 0.0198 0.0013 1044 N Y5.1 575.1 1506.9 0.025 0.0031 2082 N N

16.3 672.8 1796.2 0.0228 0.0085 2469 N N0.0 36.5 158.5 0 0 195 N N7.0 819.1 1844.9 0.0269 0.0034 2664 N N6.2 380.3 792.7 0.028 0.0066 1173 N N

12.3 770.6 1602.4 0.028 0.0066 2373 N N0.0 331.5 1057.5 0.0194 0 1389 N Y

3.1 478.4 1222.6 0.0259 0.0022 1701 N N1.0 86.1 144.9 0.0255 0.0052 231 N N2.1 429.8 1220.2 0.022 0.0016 1650 N N1.0 429.8 833.2 0.0285 0.001 1263 N N6.1 233.9 753.1 0.0214 0.0076 987 N N5.1 528.5 1280.5 0.0251 0.0036 1809 N N0.0 234.6 962.4 0.0161 0 1197 N N2.0 480.1 1157.9 0.0258 0.0016 1638 N N1.1 627.2 1352.8 0.0276 0.0007 1980 N N2.9 136.5 367.5 0.0175 0.0078 504 N N7.1 480.7 1268.3 0.025 0.0051 1749 N N1.0 87 357 0.0101 0.0029 444 N N7.1 383.1 765.9 0.0345 0.0077 1149 N N6.2 677.2 1710.8 0.0239 0.0033 2388 N Y1.0 87.4 374.6 0.0104 0.0027 462 N N0.0 137.2 321.8 0.0317 0 459 N N1.0 37.6 169.4 0 0.006 207 N N4.0 285.5 737.5 0.0207 0.0052 1023 N N0.0 482 1213 0.0241 0 1695 N N6.0 531.5 1427.5 0.0244 0.0039 1959 N N6.0 580.5 1342.5 0.0239 0.0041 1923 N N1.0 236.6 729.4 0.0178 0.0014 966 N N2.1 236.6 738.4 0.0178 0.0027 975 N N

33.8 1264.3 3100.7 0.0221 0.0102 4365 N N0.0 187.5 565.5 0.0188 0 753 N N1.0 137.9 243.1 0.024 0.0034 381 N N0.0 137.9 249.1 0.0225 0 387 N N1.1 286.5 664.5 0.0238 0.0014 951 N N1.0 138 393 0.0177 0.0024 531 N N1.0 335.9 768.1 0.0241 0.0012 1104 N N3.1 434.3 1533.7 0.019 0.0019 1968 N N2.1 237.5 533.5 0.0294 0.0034 771 N N7.0 237.6 608.4 0.0199 0.011 846 N0.0 88.4 373.6 0.0184 0 462 N N6.1 533.3 1365.7 0.0226 0.0041 1899 N N2.0 237.9 581.1 0.0219 0.0032 819 N N1.0 237.9 620.1 0.021 0.0015 858 N N4.0 188.4 795.6 0.0136 0.0053 984 N N6.1 779 1642 0.0292 0.0032 2421 N N

12.2 435.6 1031.4 0.0245 0.0106 1467 N N4.1 188.6 426.4 0.0206 0.0086 615 N N8.1 779.3 1980.7 0.024 0.0038 2760 N N1.0 188.7 510.3 0.02 0.0018 699 N N0.0 288 723 0.0221 0 1011 N Y9.1 731 1828 0.0276 0.0045 2559 N N9.0 633 1920 0.0214 0.0045 2553 N N0.0 89.1 378.9 0.0098 0 468 N N4.0 780.3 2492.7 0.02 0.0016 3273 N N3.0 288.7 971.3 0.0184 0.0031 1260 N N0.0 38.8 138.2 0 0 177 N N0.0 189.5 389.5 0.0227 0 579 N N4.1 139.6 403.4 0.0165 0.0096 543 N N9.3 288.9 686.1 0.02 0.0127 975 N N

2.0 486.4 1199.6 0.0246 0.0015 1686 N N2.1 189.7 458.3 0.0215 0.004 648 N N0.0 89.5 144.5 0.0405 0 234 N N2.0 89.5 198.5 0.015 0.0091 288 N N0.0 388.1 763.9 0.0295 0 1152 N N1.0 388.1 742.9 0.0259 0.0012 1131 N N1.1 289.2 814.8 0.0192 0.0012 1104 N Y0.0 289.3 547.7 0.0335 0 837 N N1.0 289.3 532.7 0.0356 0.0015 822 N N1.0 189.9 563.1 0.0182 0.0017 753 N N2.0 239.7 657.3 0.0197 0.0029 897 N N2.0 190 542 0.0183 0.0035 732 N N2.0 339 813 0.0265 0.0022 1152 N N0.0 89.8 159.2 0.0214 0 249 N N0.0 39.1 98.9 0 0 138 N N2.0 140.2 429.8 0.016 0.0045 570 N N0.0 90 204 0.0139 0 294 N N2.0 339.6 1073.4 0.0187 0.0018 1413 N N2.0 339.6 782.4 0.0256 0.0023 1122 N N3.1 190.5 565.5 0.0175 0.0052 756 N N0.0 240.4 422.6 0.0357 0 663 N N

12.3 290.3 729.7 0.0208 0.0156 1020 N N3.1 240.6 626.4 0.0211 0.0045 867 N N3.0 90.2 227.8 0.0123 0.0128 318 N N6.1 636.4 1640.6 0.0239 0.0034 2277 N N4.1 140.8 309.2 0.0189 0.0118 450 N N0.0 90.4 176.6 0.0168 0 267 N N2.1 686 1876 0.0226 0.001 2562 N N1.1 241.2 448.8 0.036 0.0018 690 N N4.1 882.8 2579.2 0.0227 0.0015 3462 N N

11.4 340.7 862.3 0.0221 0.012 1203 N N0.0 191.4 363.6 0.0239 0 555 N N0.0 141.2 272.8 0.0206 0 414 N N2.0 141.2 350.8 0.0196 0.0052 492 N N6.0 291.4 950.6 0.0178 0.0063 1242 N N3.0 90.8 245.2 0.0129 0.0117 336 N N0.0 241.9 496.1 0.0292 0 738 N N3.0 341.5 867.5 0.023 0.0032 1209 N N2.4 91 275 0.0175 0.009 366 N N8.1 292.1 715.9 0.0223 0.0103 1008 N N1.0 141.9 491.1 0.0151 0.002 633 N N0.0 142 251 0.0214 0 393 N N0.0 192.4 515.6 0.0177 0 708 N N5.2 392.4 1032.6 0.022 0.0045 1425 N N6.2 541.1 1285.9 0.0251 0.0042 1827 N N

13.5 91.7 307.3 0.0151 0.0431 399 N N1.0 243.1 470.9 0.0336 0.0018 714 N N6.1 541.3 1381.7 0.0244 0.004 1923 N N7.0 343.1 958.9 0.0214 0.0069 1302 N N4.0 243.3 752.7 0.0179 0.0052 996 N N6.2 591.5 1259.5 0.0256 0.0043 1851 N N0.0 40.6 178.4 0 0 219 N N4.1 492.7 1139.3 0.0253 0.0032 1632 N N

2.0 243.9 659.1 0.0212 0.0028 903 N N8.2 690.8 1583.2 0.0256 0.0046 2274 N N4.2 493 1097 0.0242 0.0033 1590 N N1.0 40.7 169.3 0 0.0062 210 N N4.0 294.1 731.9 0.0226 0.005 1026 N N2.0 193.8 526.2 0.0181 0.0036 720 N N5.0 294.3 776.7 0.0217 0.006 1071 N N1.0 143.4 345.6 0.0188 0.0026 489 N N2.0 92.5 297.5 0.0118 0.0066 390 N N0.0 40.9 226.1 0 0 267 N N2.0 394.4 1132.6 0.0198 0.0017 1527 N Y0.0 194.3 471.7 0.02 0 666 N N5.2 840 1848 0.0272 0.0024 2688 N N0.0 244.7 469.3 0.026 0 714 N N2.0 143.8 327.2 0.0287 0.0055 471 N N2.1 741.7 1913.3 0.0247 0.001 2655 N N2.1 741.7 1913.3 0.0247 0.001 2655 N N1.0 245 784 0.0174 0.0013 1029 N N1.0 245 613 0.0197 0.0015 858 N N1.0 295.3 1216.7 0.0152 0.0008 1512 N N0.0 93 165 0.0349 0 258 N N0.0 395.5 819.5 0.0254 0 1215 N N0.0 245.4 522.6 0.0308 0 768 N Y0.0 41.3 135.7 0 0 177 N7.3 345.9 689.1 0.0326 0.0086 1035 N N2.1 41.4 87.6 0 0.0194 129 N2.1 41.4 87.6 0 0.0194 129 N2.0 296 823 0.02 0.0023 1119 N N0.0 195.4 479.6 0.0196 0 675 N N5.0 346.2 1048.8 0.0192 0.0046 1395 N N8.1 245.9 564.1 0.023 0.0127 810 N N3.0 446.1 1266.9 0.0199 0.0023 1713 N N6.0 144.8 386.2 0.0172 0.0147 531 N N2.0 144.9 422.1 0.0265 0.0044 567 N N1.0 195.8 815.2 0.0142 0.0013 1011 N N6.0 595.8 1435.2 0.0244 0.0038 2031 N N3.2 695 1525 0.0259 0.0018 2220 N N1.0 296.8 879.2 0.0184 0.0011 1176 N N2.0 246.6 671.4 0.0201 0.0028 918 N N2.0 297 768 0.0215 0.0024 1065 N N5.2 745 1586 0.029 0.0028 2331 N N1.0 196.6 472.4 0.0236 0.002 669 N N0.0 196.6 373.4 0.0253 0 570 N N3.1 297.7 638.3 0.025 0.0041 936 N N1.0 196.9 445.1 0.0199 0.002 642 N N1.0 197 529 0.0178 0.0018 726 N N0.0 197.1 639.9 0.0164 0 837 N N3.3 146.1 300.9 0.0326 0.0085 447 N N2.0 498.6 1124.4 0.0245 0.0016 1623 N N2.0 498.6 1124.4 0.0245 0.0016 1623 N N0.0 42.4 251.6 0 0 294 N N0.0 349.1 1132.9 0.0197 0 1482 N N

23.7 797.3 2010.7 0.024 0.011 2808 N N

23.7 797.3 2010.7 0.024 0.011 2808 N N1.0 349.2 973.8 0.0203 0.001 1323 N N5.0 349.2 883.8 0.022 0.0052 1233 N N3.0 399.5 860.5 0.0249 0.0031 1260 N N0.0 42.6 203.4 0 0 246 N N1.1 399.8 878.2 0.025 0.001 1278 N N2.0 95.2 360.8 0.0098 0.0057 456 N N7.2 599.5 1308.5 0.0262 0.0047 1908 N N0.0 95.4 186.6 0.0153 0 282 N N0.0 147.2 260.8 0.0229 0 408 N N2.1 95.5 225.5 0.0145 0.008 321 N N7.1 500.8 1386.2 0.0219 0.0048 1887 N N4.1 147.4 587.6 0.0116 0.0072 735 N N0.0 198.7 479.3 0.0284 0 678 N N1.0 198.7 347.3 0.0271 0.0023 546 N N0.0 400.9 1318.1 0.0171 0 1719 N Y5.1 400.9 919.1 0.0248 0.0049 1320 N N7.3 451.1 1228.9 0.0196 0.0055 1680 N Y0.0 43.1 61.9 0 0 105 N N0.0 249.9 701.1 0.0196 0 951 N N1.0 147.8 287.2 0.0326 0.0029 435 N N2.0 199.1 541.9 0.0168 0.0036 741 N Y0.0 351.1 1094.9 0.0185 0 1446 N N1.0 300.9 518.1 0.0364 0.0015 819 N N2.0 148 464 0.0143 0.0043 612 N N7.0 401.9 1134.1 0.0219 0.0058 1536 N N0.0 96.3 164.7 0.0398 0 261 N N0.0 199.6 448.4 0.0217 0 648 N N0.0 43.4 97.6 0.036 0 141 N N0.0 43.4 160.6 0 0 204 N N7.0 199.7 571.3 0.018 0.0117 771 N N0.0 301.4 607.6 0.0305 0 909 N N1.0 250.8 652.2 0.0204 0.0014 903 N N0.0 43.5 97.5 0 0 141 N2.0 352.1 754.9 0.0249 0.0023 1107 N Y4.1 301.6 625.4 0.0253 0.0055 927 N N0.0 250.9 781.1 0.0172 0 1032 N N3.1 251 610 0.0255 0.0046 861 N N7.1 200.1 642.9 0.0176 0.0105 843 N N0.0 96.7 170.3 0.0282 0 267 N N0.0 96.7 200.3 0.0165 0 297 N N0.0 43.7 163.3 0 0 207 N N1.0 96.8 377.2 0.0104 0.0027 474 N N0.0 200.3 414.7 0.0232 0 615 N N1.0 403.1 1213.9 0.0192 0.0008 1617 N N0.0 603.8 1457.2 0.0225 0 2061 N Y1.0 43.8 235.2 0 0.0046 279 N N

10.9 553.9 1078.1 0.0306 0.0082 1632 N N0.0 43.9 109.1 0 0 153 N N5.1 554.3 1581.7 0.0222 0.003 2136 N N1.9 403.8 1297.2 0.0199 0.0015 1701 N N0.0 44 163 0 0 207 N N0.0 149.6 303.4 0.0297 0 453 N N

2.1 252.5 572.5 0.0213 0.0032 825 N N2.0 252.5 704.5 0.0185 0.0027 957 N N1.0 252.6 635.4 0.0217 0.0014 888 N N0.0 252.6 725.4 0.0192 0 978 N N5.1 303.6 716.4 0.0233 0.0063 1020 N N1.1 97.7 184.3 0.016 0.0046 282 N N0.0 252.8 707.2 0.0186 0 960 N N0.0 252.8 671.2 0.019 0 924 N N1.0 201.6 746.4 0.014 0.0014 948 N N

13.2 855.1 2270.9 0.0225 0.0054 3126 N N3.0 505.6 1432.4 0.0214 0.002 1938 N N6.1 405.2 965.8 0.0218 0.0058 1371 N N0.0 253.1 775.9 0.0168 0 1029 N N0.0 253.3 595.7 0.0195 0 849 N Y3.0 456.2 974.8 0.0272 0.0027 1431 N N2.1 606.9 1871.1 0.0211 0.001 2478 N N0.0 253.6 904.4 0.0161 0 1158 N N2.0 557 1633 0.0207 0.0012 2190 N N6.1 304.7 685.3 0.0235 0.0078 990 N N

10.3 406.1 1126.9 0.0246 0.0084 1533 N N2.0 253.9 625.1 0.0231 0.0028 879 N N1.0 253.9 475.1 0.0263 0.0017 729 N N4.1 355.7 748.3 0.0253 0.0047 1104 N N0.0 44.8 171.2 0 0 216 N N2.0 202.7 775.3 0.0136 0.0027 978 N N5.0 406.5 1132.5 0.0221 0.0041 1539 N N0.0 305.1 873.9 0.0186 0 1179 N N6.2 151 326 0.0204 0.0161 477 N N2.0 254.2 525.8 0.0222 0.0034 780 N N0.0 203 424 0.0314 0 627 N N

24.3 1057.2 2890.8 0.0238 0.0078 3948 N N5.1 203.2 408.8 0.0228 0.0105 612 N N3.1 457.9 964.1 0.0299 0.0027 1422 N N2.1 356.8 855.2 0.0268 0.0021 1212 N N0.0 508.5 1117.5 0.0234 0 1626 N N1.0 99.1 260.9 0.011 0.0037 360 N

14.4 859.1 1891.9 0.0269 0.0066 2751 N N1.0 357.1 1007.9 0.0193 0.001 1365 N N2.0 306.3 650.7 0.024 0.0027 957 N N7.1 306.5 656.5 0.018 0.0106 963 N N6.1 408.2 1109.8 0.02 0.0052 1518 N N2.0 152 400 0.0184 0.0045 552 N N2.1 204.2 503.8 0.0264 0.0036 708 N N2.1 204.2 536.8 0.0176 0.0035 741 N N2.0 204.4 674.6 0.0148 0.003 879 N N6.2 358.3 790.7 0.0242 0.0067 1149 N N2.1 307.4 976.6 0.0179 0.002 1284 N N7.1 307.5 871.5 0.0178 0.0079 1179 N N0.0 152.7 282.3 0.0199 0 435 N Y0.0 45.8 191.2 0 0 237 N N1.0 358.8 733.2 0.0267 0.0012 1092 N Y2.0 358.9 877.1 0.0252 0.0021 1236 N N3.1 409.8 874.2 0.0251 0.003 1284 N N

0.0 256.8 526.2 0.0289 0 783 N N0.0 153.2 305.8 0.0188 0 459 N N7.1 257 697 0.0178 0.0097 954 N N1.0 359.4 1107.6 0.017 0.0009 1467 N N5.1 308.4 846.6 0.0186 0.0057 1155 N N6.2 913.2 2572.8 0.0223 0.0022 3486 N N3.0 360.2 869.8 0.0208 0.0032 1230 N Y2.1 258 657 0.0224 0.0029 915 N N6.2 764.4 1932.6 0.0249 0.0028 2697 N Y1.0 258.1 827.9 0.0166 0.0012 1086 N N5.0 513.2 1511.8 0.019 0.0032 2025 N N3.0 206.6 417.4 0.0227 0.0062 624 N N3.0 206.7 726.3 0.0145 0.0042 933 N N0.0 310 614 0.0316 0 924 N N0.0 361.2 1024.8 0.0198 0 1386 N N6.3 715.2 1471.8 0.0279 0.0036 2187 N N1.0 154.5 280.5 0.02 0.003 435 N N2.0 207.1 548.9 0.0186 0.0034 756 N N1.0 665.7 1464.3 0.0239 0.0006 2130 N N7.0 615.4 1742.6 0.0215 0.0038 2358 N N7.1 816.9 2213.1 0.0234 0.0029 3030 N N0.0 47.1 192.9 0 0 240 N N

11.0 311.1 921.9 0.0192 0.0114 1233 N N0.0 155.2 300.8 0.0181 0 456 N N2.0 47.2 123.8 0 0.0151 171 N3.0 362.7 1161.3 0.0181 0.0025 1524 N N8.1 717.5 2138.5 0.0206 0.0036 2856 N N0.0 566.4 1140.6 0.0259 0 1707 N N0.0 363 726 0.0254 0 1089 N N2.0 260.1 894.9 0.017 0.0022 1155 N N4.2 311.8 723.2 0.0241 0.0051 1035 N N6.1 311.8 714.2 0.0215 0.0076 1026 N N3.0 768.2 1661.8 0.0258 0.0016 2430 N Y5.1 311.9 936.1 0.0188 0.0051 1248 N N3.1 617.7 1410.3 0.0254 0.0019 2028 N N6.0 465.8 1256.2 0.0221 0.0044 1722 N N2.0 156.1 413.9 0.0168 0.0045 570 N N0.0 466.2 877.8 0.0289 0 1344 N N1.0 261.1 530.9 0.0217 0.0017 792 N N1.0 364.2 799.8 0.0241 0.0011 1164 N N0.0 517.4 1153.6 0.0232 0 1671 N7.2 466.6 1360.4 0.0199 0.0049 1827 N N1.1 770.3 2139.7 0.0223 0.0004 2910 N N7.1 466.9 1282.1 0.0215 0.0051 1749 N N2.1 364.7 1033.3 0.0201 0.0018 1398 N N4.0 365 1249 0.0168 0.0032 1614 N N1.0 157 440 0.0154 0.0021 597 N N3.0 262.2 757.8 0.0183 0.0038 1020 N N1.0 314.1 771.9 0.0202 0.0012 1086 N N0.0 48.4 194.6 0 0 243 N N5.0 262.6 697.4 0.0172 0.0069 960 N N

11.6 314.7 936.3 0.018 0.0123 1251 N N3.1 210.7 377.3 0.0229 0.0066 588 N N

5.1 417.9 1079.1 0.022 0.0043 1497 N N3.1 418 1145 0.0197 0.0025 1563 N N2.0 158.2 240.8 0.0233 0.0064 399 N N1.1 158.3 225.7 0.0396 0.0033 384 N N0.0 48.9 119.1 0.0304 0 168 N N0.0 49 236 0 0 285 N N5.3 470 997 0.0263 0.0045 1467 N N2.1 315.8 854.2 0.0236 0.0022 1170 N N2.0 315.8 1001.2 0.0189 0.0019 1317 N N2.0 622.7 1543.3 0.0231 0.0012 2166 N N8.2 622.7 1432.3 0.0229 0.0051 2055 N N0.0 104.7 174.3 0.0343 0 279 N N5.1 470.2 1371.8 0.0193 0.0035 1842 N N1.0 49.1 121.9 0 0.0074 171 N N5.1 623.4 1707.6 0.0199 0.0028 2331 N N1.0 105 333 0.0105 0.0029 438 N N2.1 159.1 503.9 0.013 0.004 663 N N0.0 316.6 979.4 0.0184 0 1296 N N1.0 264.6 650.4 0.0205 0.0014 915 N N3.1 316.7 784.3 0.0225 0.0036 1101 N N0.0 316.7 895.3 0.0193 0 1212 N N1.1 368.5 756.5 0.0222 0.0012 1125 N Y6.1 522.4 1247.6 0.0212 0.0045 1770 N N1.0 105.3 191.7 0.0161 0.0043 297 N N6.2 265 803 0.0157 0.0074 1068 N N0.0 105.4 206.6 0.0332 0 312 N N4.0 212.6 543.4 0.0179 0.0069 756 N N3.9 624.8 2063.2 0.0185 0.0019 2688 N N0.0 212.8 504.2 0.0195 0 717 N N2.0 472.6 928.4 0.0267 0.0018 1401 N N0.0 49.9 274.1 0 0 324 N N2.0 265.9 601.1 0.0212 0.003 867 N N8.1 318.1 905.9 0.0203 0.0083 1224 N Y1.0 213.5 392.5 0.0222 0.0021 606 N N1.0 370.1 655.9 0.0286 0.0012 1026 N N1.0 106.1 367.9 0.0089 0.0028 474 N Y1.0 50.1 114.9 0 0.008 165 N N4.1 677.3 1566.7 0.0235 0.0023 2244 N N1.0 422.1 1206.9 0.0187 0.0008 1629 N N9.2 626.9 1728.1 0.0212 0.0049 2355 N N5.0 370.8 931.2 0.0214 0.0049 1302 N N

10.0 931 2939 0.0202 0.0033 3870 N N0.0 161 697 0.0105 0 858 N N3.1 161 376 0.0171 0.0072 537 N N0.0 371.3 933.7 0.0206 0 1305 N N2.0 214.5 520.5 0.0175 0.0036 735 N N0.0 267.4 806.6 0.0173 0 1074 N N2.0 319.7 748.3 0.0196 0.0025 1068 N Y0.0 267.5 509.5 0.0219 0 777 N N8.3 371.8 798.2 0.0252 0.0087 1170 N N1.0 214.9 529.1 0.0233 0.0018 744 N N0.0 50.7 144.3 0 0 195 N N4.2 215 490 0.0227 0.0076 705 N N

1.0 161.6 420.4 0.0156 0.0022 582 N N1.0 423.9 1118.1 0.0209 0.0008 1542 N N0.0 161.7 327.3 0.0182 0 489 N N5.0 215.3 672.7 0.0164 0.0071 888 N N2.0 215.3 507.7 0.0174 0.0037 723 N N1.0 215.4 762.6 0.0139 0.0013 978 N N2.3 527.5 1071.5 0.0245 0.002 1599 N N1.0 107.6 195.4 0.0321 0.0042 303 N N0.0 268.6 1063.4 0.0128 0 1332 N Y6.3 373.1 892.9 0.025 0.0061 1266 N N1.0 321.1 968.9 0.0167 0.001 1290 N N3.0 373.2 901.8 0.0208 0.0031 1275 N N0.0 107.8 177.2 0.016 0 285 N N0.0 107.9 369.1 0.0176 0 477 N N0.0 51.3 170.7 0 0 222 N N2.1 269.3 513.7 0.0222 0.0033 783 N N2.0 269.5 735.5 0.0187 0.0025 1005 N N2.1 269.5 675.5 0.0174 0.0028 945 N N2.1 163 437 0.0238 0.0042 600 N N4.2 374.3 708.7 0.0255 0.0048 1083 N N1.0 163.1 502.9 0.0136 0.0019 666 N N1.0 322.2 613.8 0.0225 0.0014 936 N N3.1 632.3 1536.7 0.0215 0.0018 2169 N N4.1 785.1 1761.9 0.0244 0.002 2547 N N0.0 51.8 248.2 0 0 300 N N1.0 322.9 859.1 0.0176 0.0011 1182 N N0.0 108.9 200.1 0.0323 0 309 N N2.0 581.9 1122.1 0.0263 0.0015 1704 N Y2.0 270.7 632.3 0.0202 0.0029 903 N N8.2 427.6 1102.4 0.021 0.0067 1530 N N3.0 270.9 593.1 0.0202 0.0045 864 N N9.2 530.9 1263.1 0.0245 0.0066 1794 N N1.0 109.2 346.8 0.0096 0.0029 456 N N0.0 217.9 424.1 0.0212 0 642 N N3.0 217.9 439.1 0.0173 0.0063 657 N N0.0 52.2 121.8 0 0 174 N N0.0 271.1 532.9 0.03 0 804 N N8.0 938.8 2655.2 0.0226 0.0028 3594 N N0.0 109.3 193.7 0.0321 0 303 N N1.0 531.4 1289.6 0.0214 0.0007 1821 N Y0.0 109.4 193.6 0.015 0 303 N N0.0 52.3 148.7 0 0 201 N N2.0 218.2 501.8 0.0179 0.0036 720 N N

11.0 888.6 2567.4 0.021 0.0041 3456 N N7.3 787.5 2026.5 0.0217 0.0033 2814 N N8.1 838.5 1894.5 0.0246 0.0038 2733 N N0.0 109.8 226.2 0.0291 0 336 N N0.0 52.6 235.4 0 0 288 N4.0 272 787 0.0175 0.0048 1059 N Y2.1 218.9 456.1 0.0187 0.0039 675 N N5.0 324.9 788.1 0.0191 0.0059 1113 N N1.0 52.7 313.3 0 0.0035 366 N N0.9 165.3 728.7 0.0105 0.0014 894 N N

3.1 738.4 2036.6 0.0215 0.0014 2775 N N0.0 110.3 216.7 0.0145 0 327 N N1.0 482 1072 0.0211 0.0009 1554 N N2.1 325.7 679.3 0.0221 0.0026 1005 N N0.0 165.7 299.3 0.0295 0 465 N N5.0 165.7 536.3 0.0122 0.0094 702 N N0.0 636.7 1589.3 0.021 0 2226 N N1.0 165.8 530.2 0.0141 0.0018 696 N N

10.1 273.2 833.8 0.0158 0.0118 1107 N N1.0 482.5 1086.5 0.0257 0.0008 1569 N N

11.2 637.1 1720.9 0.0205 0.0061 2358 N N5.0 688.4 1864.6 0.0208 0.0025 2553 N N1.0 110.8 396.2 0.0089 0.0025 507 N N4.0 378.8 1136.2 0.0187 0.0034 1515 N N1.0 220.2 466.8 0.0204 0.0019 687 N N4.1 482.9 1128.1 0.021 0.0033 1611 N N0.0 53.4 225.6 0 0 279 N N2.0 893.4 2217.6 0.0238 0.0008 3111 N N1.0 166.5 688.5 0.0108 0.0015 855 N N1.0 483.9 1229.1 0.0194 0.0008 1713 N N2.0 220.9 688.1 0.0155 0.0028 909 N N0.0 484 1220 0.0202 0 1704 N N0.0 53.7 102.3 0 0 156 N N0.0 53.7 165.3 0 0 219 N N4.0 379.9 874.1 0.023 0.0041 1254 N N6.1 690.2 1649.8 0.0244 0.0033 2340 N N0.0 327.5 974.5 0.0171 0 1302 N N2.0 690.4 1676.6 0.0234 0.0011 2367 N N0.0 111.7 212.3 0.015 0 324 N N5.2 328 818 0.0231 0.0057 1146 N N0.0 484.9 940.1 0.0264 0 1425 N N6.1 588.9 1460.1 0.0212 0.0038 2049 N N9.0 328.8 964.2 0.0169 0.0091 1293 N N7.2 589.3 1459.7 0.0225 0.0044 2049 N N0.0 112.3 190.7 0.0306 0 303 N N0.0 167.9 354.1 0.017 0 522 N N6.3 486 1122 0.0206 0.005 1608 N N6.1 276 684 0.0201 0.008 960 N N6.1 276.1 899.9 0.016 0.0065 1176 N N1.0 222.5 638.5 0.0164 0.0015 861 N N0.0 112.5 232.5 0.0122 0 345 N1.0 329.2 825.8 0.0236 0.0011 1155 N N1.0 329.2 909.8 0.0167 0.0011 1239 N N3.0 112.6 262.4 0.0116 0.0105 375 N N

12.1 641.6 1779.4 0.0195 0.0065 2421 N N2.0 222.8 512.2 0.0251 0.0035 735 N N0.0 54.6 197.4 0 0 252 N N1.0 329.6 648.4 0.0248 0.0013 978 N N0.0 112.8 217.2 0.0131 0 330 N N0.0 276.6 764.4 0.0174 0 1041 N N9.1 276.6 614.4 0.0211 0.013 891 N N5.0 486.9 1655.1 0.0171 0.003 2142 N N3.3 223 617 0.0196 0.0053 840 N N

0.0 54.7 227.3 0 0 282 N N0.0 54.7 170.3 0 0 225 N N0.0 223.1 688.9 0.0146 0 912 N N1.0 330.1 758.9 0.0204 0.0012 1089 N N2.0 277.1 610.9 0.0193 0.003 888 N N0.0 169 548 0.0122 0 717 N N1.0 169 311 0.0188 0.0027 480 N N2.0 488.1 1125.9 0.0226 0.0016 1614 N N0.0 113.4 249.6 0.0108 0 363 N N8.3 848.6 2064.4 0.0232 0.0036 2913 N N2.0 223.8 817.2 0.0122 0.0025 1041 N Y7.2 643.7 1534.3 0.0249 0.0042 2178 N N8.2 436.3 1096.7 0.0215 0.0067 1533 N N6.3 277.9 625.1 0.0248 0.0087 903 N N7.9 540.6 1496.4 0.02 0.0051 2037 N N7.1 488.7 1149.3 0.0219 0.0055 1638 N N0.0 55.3 268.7 0 0 324 N N6.1 384.1 1025.9 0.0195 0.0055 1410 N N7.2 436.7 955.3 0.0232 0.0065 1392 N N5.1 592.8 1603.2 0.0207 0.0029 2196 N N0.0 55.4 169.6 0 0 225 N N0.0 114 231 0.025 0 345 N N4.0 489.4 1202.6 0.023 0.003 1692 N N2.1 278.5 642.5 0.0193 0.0028 921 N N0.0 224.7 525.3 0.0217 0 750 N N1.1 170.1 885.9 0.0128 0.0012 1056 N N7.2 384.8 983.2 0.0182 0.0068 1368 N N7.0 384.9 1094.1 0.0182 0.0061 1479 N N1.1 332.2 702.8 0.0209 0.0013 1035 N N2.0 278.9 969.1 0.0139 0.0021 1248 N N3.1 593.9 1464.1 0.0218 0.0019 2058 N N2.1 437.9 1284.1 0.0189 0.0015 1722 N N5.2 385.6 679.4 0.0248 0.0061 1065 N N2.2 333.1 713.9 0.0226 0.0031 1047 N N1.0 226 614 0.021 0.0015 840 N N1.0 171.2 539.8 0.0132 0.0018 711 N N2.0 386.5 942.5 0.0193 0.002 1329 N N0.0 115.1 229.9 0.0122 0 345 N N0.0 171.3 269.7 0.0335 0 441 N N1.0 386.6 915.4 0.0208 0.001 1302 N N5.0 280.2 883.8 0.0153 0.0056 1164 N N2.0 333.7 908.3 0.0173 0.0021 1242 N N3.0 171.6 488.4 0.014 0.0058 660 N N1.9 439.8 1294.2 0.0187 0.0015 1734 N N6.0 544.8 1507.2 0.0199 0.0038 2052 N N4.0 172 455 0.0136 0.0084 627 N N6.1 648.9 1457.1 0.0274 0.0036 2106 N N6.1 387.9 1085.1 0.0187 0.0052 1473 N N2.1 281.4 714.6 0.0181 0.0026 996 N N0.0 804 1695 0.0246 0 2499 N N0.0 57 231 0 0 288 N N2.0 57.1 95.9 0 0.0169 153 N N

14.4 1162.7 3061.3 0.0227 0.0043 4224 N N

10.6 805.3 1681.7 0.029 0.0051 2487 N N3.1 335.9 810.1 0.0185 0.0034 1146 N Y4.2 336 786 0.0206 0.0046 1122 N N1.0 57.6 323.4 0 0.0033 381 N N1.0 117 393 0.009 0.0025 510 N N5.0 443 1285 0.0182 0.0037 1728 N N2.1 495.6 1103.4 0.0216 0.0016 1599 N0.0 57.7 188.3 0 0 246 N N2.0 229 608 0.0147 0.0032 837 N N2.1 390.3 788.7 0.0248 0.0021 1179 N N1.0 117.2 434.8 0.0086 0.0023 552 N N0.0 443.3 1281.7 0.0183 0 1725 N N0.0 57.8 215.2 0 0 273 N N0.0 173.9 357.1 0.0237 0 531 N N0.0 117.3 251.7 0.0228 0 369 N N1.0 229.2 619.8 0.0158 0.0015 849 N N2.0 174 531 0.0126 0.0037 705 N N6.0 548.5 1308.5 0.0222 0.0042 1857 N N4.0 337.4 754.6 0.0199 0.0048 1092 N Y2.0 174.1 455.9 0.0144 0.0041 630 N N1.0 390.9 1112.1 0.0174 0.0009 1503 N N2.1 117.6 326.4 0.0207 0.0058 444 N N7.1 601.2 1270.8 0.0246 0.0048 1872 N N3.0 284.1 660.9 0.0175 0.0042 945 N N2.1 444.4 1055.6 0.0216 0.0017 1500 N N0.0 284.4 564.6 0.0205 0 849 N N6.1 444.5 1262.5 0.0195 0.0045 1707 N N5.0 705.8 1934.2 0.0214 0.0024 2640 N N4.1 602.2 1425.8 0.0233 0.0026 2028 N N7.1 284.7 750.3 0.0172 0.0088 1035 N N

13.2 445.1 1195.9 0.0207 0.0101 1641 N N4.1 339 666 0.0209 0.0053 1005 N N4.2 392.4 747.6 0.0279 0.0045 1140 N N4.1 175.3 436.7 0.0141 0.0086 612 N N2.0 285.3 731.7 0.0198 0.0025 1017 N N3.0 285.3 620.7 0.0212 0.0042 906 N N7.0 446 1129 0.0199 0.0058 1575 N N2.0 231.1 410.9 0.0231 0.0039 642 N N5.1 393 681 0.0274 0.0059 1074 N N6.0 498.9 1283.1 0.0206 0.0043 1782 N Y4.1 655.8 1948.2 0.0183 0.0022 2604 N N0.0 118.8 331.2 0.0098 0 450 N N8.1 446.5 1032.5 0.0203 0.0071 1479 N N0.0 499.5 1033.5 0.0213 0 1533 N N1.0 231.6 752.4 0.0132 0.0013 984 N N0.0 446.8 1092.2 0.0203 0 1539 N N5.0 499.6 1261.4 0.021 0.0036 1761 N N1.0 231.7 623.3 0.0151 0.0015 855 N N6.0 340.3 1072.7 0.0166 0.0054 1413 N N6.1 760.7 1897.3 0.0229 0.0029 2658 N N4.1 176.3 453.7 0.0141 0.0083 630 N N3.0 394 869 0.0216 0.0031 1263 N N0.0 119.3 498.7 0.0072 0 618 N N

0.0 176.4 441.6 0.0218 0 618 N N1.1 552.9 1355.1 0.0213 0.0007 1908 N N1.0 59.4 123.6 0 0.0071 183 N N5.1 119.6 240.4 0.0107 0.019 360 N N7.0 232.8 682.2 0.0148 0.0099 915 N N3.1 287.6 837.4 0.0162 0.0034 1125 N N3.0 177.2 380.8 0.0177 0.0068 558 N N0.0 59.8 192.2 0 0 252 N N

10.0 762.8 1826.2 0.0235 0.0049 2589 N N3.0 287.9 780.1 0.0162 0.0037 1068 N N1.0 659.1 1455.9 0.024 0.0006 2115 N N1.0 554.6 1305.4 0.0227 0.0007 1860 N N4.0 342.4 854.6 0.0189 0.0043 1197 N N8.4 554.9 1005.1 0.023 0.0069 1560 N N1.0 396.2 986.8 0.0191 0.0009 1383 N N1.0 177.8 305.2 0.0177 0.0027 483 N N2.0 120.5 320.5 0.0098 0.0059 441 N N0.0 60.2 203.8 0.0163 0 264 N N2.0 233.9 636.1 0.0143 0.003 870 N N1.0 233.9 486.1 0.0176 0.0018 720 N N2.0 178.2 538.8 0.0114 0.0037 717 N N1.0 450.3 872.7 0.0234 0.001 1323 N Y1.0 289.1 592.9 0.0209 0.0015 882 N N3.0 765.2 1868.8 0.0213 0.0015 2634 N N1.0 121.1 427.9 0.0079 0.0024 549 N N0.0 60.6 284.4 0 0 345 N N5.0 450.9 1292.1 0.0174 0.0038 1743 N N3.1 178.8 463.2 0.0209 0.0061 642 N N3.1 344 664 0.0227 0.0038 1008 N N0.0 60.8 278.2 0 0 339 N N3.0 398 841 0.0225 0.0031 1239 N N0.0 121.5 292.5 0.0106 0 414 N N3.0 235.2 451.8 0.0215 0.0055 687 N N1.0 121.7 421.3 0.0084 0.0024 543 N N4.1 451.8 1405.2 0.0172 0.0028 1857 N N2.0 344.6 843.4 0.019 0.0022 1188 N N4.2 235.3 541.7 0.0172 0.0067 777 N0.0 121.8 217.2 0.0219 0 339 N N3.1 452.1 960.9 0.0214 0.0028 1413 N N0.0 61.1 136.9 0.0224 0 198 N N0.0 344.9 687.1 0.0213 0 1032 N N7.2 345 969 0.0163 0.007 1314 N N0.0 61.2 283.8 0 0 345 N N1.0 345.3 908.7 0.0196 0.001 1254 N N2.1 236 430 0.022 0.0038 666 N N1.0 236.4 798.6 0.0128 0.0013 1035 N N2.0 180.3 539.7 0.0121 0.0036 720 N N0.0 61.7 352.3 0 0 414 N N0.0 237.3 482.7 0.0266 0 720 N N0.0 292.6 838.4 0.0152 0 1131 N Y2.0 123.3 338.7 0.0097 0.0056 462 N N6.2 822.9 2201.1 0.021 0.0026 3024 N N6.2 62.2 177.8 0 0.0319 240 N

8.2 401.4 975.6 0.0232 0.0075 1377 N N0.0 123.5 257.5 0.0232 0 381 N N3.1 508.5 1327.5 0.0194 0.0021 1836 N N8.1 666.8 1892.2 0.0201 0.004 2559 N N4.0 347.8 789.2 0.0203 0.0045 1137 N N1.1 123.7 200.3 0.0141 0.004 324 N N0.0 62.6 195.4 0 0 258 N6.1 509.4 1089.6 0.0234 0.0048 1599 N N1.0 293.8 615.2 0.02 0.0014 909 N N2.1 509.5 1206.5 0.0195 0.0015 1716 N N5.0 509.6 1458.4 0.0198 0.0032 1968 N N1.0 62.7 129.3 0 0.0071 192 N N5.0 772.7 1861.3 0.0226 0.0024 2634 N Y0.0 509.8 1209.2 0.0248 0 1719 N N1.1 348.7 1055.3 0.0155 0.0009 1404 N N0.0 62.8 216.2 0 0 279 N N2.1 456.6 1091.4 0.0191 0.0017 1548 N N3.1 563.2 1707.8 0.0182 0.0017 2271 N N3.0 510.3 1040.7 0.0218 0.0026 1551 N N0.0 124.5 253.5 0.0113 0 378 N N4.1 403.4 928.6 0.02 0.0039 1332 N N0.0 294.6 560.4 0.0195 0 855 N Y0.0 182.8 741.2 0.0097 0 924 N N7.2 239.3 624.7 0.0209 0.0105 864 N N4.1 239.3 741.7 0.0135 0.0053 981 N N5.0 182.9 489.1 0.0134 0.0096 672 N N1.0 124.8 352.2 0.0182 0.0027 477 N N1.0 404.1 630.9 0.0287 0.0012 1035 N N1.0 183.4 437.6 0.0151 0.0021 621 N N0.0 183.4 374.6 0.0159 0 558 N N1.0 63.5 257.5 0 0.004 321 N N2.1 511.8 1063.2 0.0219 0.0017 1575 N Y5.1 350.5 915.5 0.0185 0.0051 1266 N N

11.2 827.9 1698.1 0.027 0.0055 2526 N N5.0 240.6 620.4 0.0152 0.0076 861 N N2.0 184 650 0.0104 0.0031 834 N N2.1 240.7 932.3 0.0125 0.0022 1173 N N1.0 296.3 753.7 0.0174 0.0012 1050 N N0.0 125.7 351.3 0.0084 0 477 N N0.0 125.8 291.2 0.0204 0 417 N N0.0 125.8 189.2 0.0137 0 315 N N

14.1 671.9 1812.1 0.0223 0.0071 2484 N N4.0 241 788 0.013 0.005 1029 N N1.0 125.9 234.1 0.0129 0.0036 360 N N1.0 64 209 0 0.0048 273 N N4.1 351.5 797.5 0.0193 0.0045 1149 N7.1 513.4 1232.6 0.0193 0.0053 1746 N N7.1 619.6 1567.4 0.0237 0.0041 2187 N N1.0 777.6 1724.4 0.0249 0.0005 2502 N N0.0 241.4 826.6 0.013 0 1068 N N3.0 184.7 706.3 0.0104 0.0043 891 N N3.0 241.5 409.5 0.0318 0.0058 651 N N7.1 672.9 1415.1 0.0239 0.0043 2088 N N

0.0 64.3 190.7 0 0 255 N N3.0 352.6 931.4 0.019 0.003 1284 N N2.0 461.1 1128.9 0.0201 0.0016 1590 N N2.0 461.1 969.9 0.0203 0.0019 1431 N N0.0 185.4 480.6 0.0196 0 666 N N0.0 242.3 693.7 0.0142 0 936 N N8.2 461.5 894.5 0.0232 0.0077 1356 N N4.0 242.4 720.6 0.0149 0.0053 963 N N0.0 621.7 1541.3 0.0231 0 2163 N N0.0 621.7 1541.3 0.0231 0 2163 N N0.0 64.8 244.2 0 0 309 N N1.0 242.7 513.3 0.0228 0.0017 756 N N0.0 884.6 1980.4 0.0237 0 2865 N Y0.0 127.2 181.8 0.013 0 309 N N0.0 780.5 2018.5 0.0209 0 2799 N N0.0 65.1 282.9 0 0 348 N N1.1 462.8 956.2 0.0225 0.0009 1419 N N3.0 354.5 908.5 0.0181 0.0031 1263 N N3.0 728.9 1692.1 0.0217 0.0016 2421 N N1.0 676.2 2026.8 0.0189 0.0005 2703 N N2.0 299.5 1047.5 0.0139 0.0019 1347 N N

11.2 781.7 1891.3 0.0243 0.0053 2673 N N3.0 243.7 686.3 0.0163 0.004 930 N N1.0 409.3 1219.7 0.0159 0.0008 1629 N N5.1 409.5 856.5 0.0229 0.005 1266 N N3.0 187.1 334.9 0.0191 0.0072 522 N N3.0 730 1784 0.0223 0.0015 2514 N N5.0 571.3 1564.7 0.0179 0.0031 2136 N N2.0 410 958 0.0209 0.0019 1368 N N5.1 624.7 1607.3 0.0206 0.0029 2232 N N2.0 355.8 817.2 0.0178 0.0023 1173 N N1.0 244.8 607.2 0.0156 0.0015 852 N N1.0 187.7 382.3 0.0158 0.0023 570 N N

13.5 244.9 721.1 0.0148 0.0173 966 N2.0 356.2 1071.8 0.0161 0.0018 1428 N N0.0 626.1 1446.9 0.0219 0 2073 N N0.0 188.2 378.8 0.016 0 567 N N1.0 245.5 459.5 0.0213 0.0018 705 N N2.0 357 1098 0.0152 0.0018 1455 N N1.0 245.8 834.2 0.0121 0.0012 1080 N Y1.0 129.7 410.3 0.0087 0.0024 540 N N5.0 521.1 1716.9 0.0166 0.0029 2238 N N1.0 246.7 539.3 0.0246 0.0016 786 N N4.2 575.1 1344.9 0.0218 0.0027 1920 N N0.0 358.5 919.5 0.0167 0 1278 N N6.0 358.5 730.5 0.0219 0.007 1089 N N2.1 521.6 1284.4 0.0184 0.0015 1806 N Y2.0 413.4 999.6 0.0183 0.0019 1413 N N6.1 521.7 1410.3 0.0203 0.0039 1932 N N0.9 575.7 1854.3 0.0172 0.0005 2430 N N2.0 190.1 463.9 0.0144 0.0039 654 N N2.0 893.6 2019.4 0.0232 0.0009 2913 N N2.0 893.6 2019.4 0.0232 0.0009 2913 N N

3.0 522.8 1493.2 0.0182 0.0019 2016 N N2.0 522.9 1205.1 0.02 0.0015 1728 N N1.0 247.8 466.2 0.0204 0.0018 714 N N3.1 468.9 965.1 0.0259 0.0027 1434 N N0.0 131.1 279.9 0.0222 0 411 N N3.0 248.1 1110.9 0.0104 0.0028 1359 N N0.0 248.1 447.9 0.019 0 696 N N6.1 414.9 941.1 0.023 0.0057 1356 N N2.0 577.1 1180.9 0.0241 0.0015 1758 N N6.2 190.6 517.4 0.0137 0.0108 708 N N4.0 469.4 1681.6 0.0156 0.0024 2151 N N0.0 248.7 483.3 0.0186 0 732 N N4.0 524.2 1527.8 0.0178 0.0025 2052 N N9.0 305.3 711.7 0.0164 0.0118 1017 N N9.0 305.3 711.7 0.0164 0.0118 1017 N0.0 248.9 873.1 0.012 0 1122 N N1.0 191.5 396.5 0.0241 0.0022 588 N N3.0 305.7 1560.3 0.0104 0.002 1866 N N1.0 68.4 138.6 0.0268 0.0059 207 N N2.0 470.9 1191.1 0.0176 0.0016 1662 N N2.9 416.4 1395.6 0.0148 0.0021 1812 N N4.0 249.3 710.7 0.0144 0.0054 960 N N1.0 249.4 605.6 0.0156 0.0015 855 N N0.0 68.5 243.5 0 0 312 N N2.1 361.6 1084.4 0.0165 0.0018 1446 N N3.0 191.9 519.1 0.0138 0.0053 711 N N1.0 306.2 908.8 0.016 0.001 1215 N N2.0 362 907 0.0189 0.002 1269 N N2.0 249.9 578.1 0.0178 0.003 828 N N

15.4 739.9 1900.1 0.0204 0.0074 2640 N N3.1 417.4 911.6 0.0232 0.0029 1329 N N1.0 192.4 410.6 0.0162 0.0021 603 N N1.0 132.9 575.1 0.0064 0.0018 708 N N0.0 307.2 673.8 0.0165 0 981 N N2.0 250.6 703.4 0.0138 0.0027 954 N N6.5 473 1153 0.0218 0.0051 1626 N N2.0 133.2 298.8 0.0221 0.0059 432 N N1.0 418.5 946.5 0.0196 0.0009 1365 N N0.0 473.3 1272.7 0.0209 0 1746 N N0.0 133.3 265.7 0.0111 0 399 N N2.0 581.5 1575.5 0.018 0.0012 2157 N N2.1 418.7 1027.3 0.0177 0.0018 1446 N Y3.0 307.8 823.2 0.0166 0.0034 1131 N N0.0 133.4 253.6 0.0113 0 387 N N1.0 473.5 942.5 0.024 0.0009 1416 N N1.0 133.5 235.5 0.0121 0.0035 369 N Y3.0 364 776 0.0196 0.0034 1140 N N7.1 528.5 1370.5 0.0191 0.0048 1899 N Y5.0 636.4 1568.6 0.0208 0.0029 2205 N N6.2 252 510 0.0262 0.01 762 N N2.1 134.1 336.9 0.0097 0.0055 471 N N

10.2 420.5 1097.5 0.017 0.0087 1518 N N4.1 475.3 1243.7 0.019 0.003 1719 N N

0.0 70.2 253.8 0 0 324 N N5.2 475.5 991.5 0.0241 0.0044 1467 N N0.0 70.3 94.7 0 0 165 N N3.0 252.8 818.2 0.0129 0.0036 1071 N N5.0 584.1 1305.9 0.0229 0.0034 1890 N N0.0 194.8 444.2 0.0137 0 639 N N1.0 309.8 563.2 0.0214 0.0015 873 N N0.0 194.9 306.1 0.0198 0 501 N N1.0 366.2 854.8 0.0178 0.0011 1221 N N0.0 135 303 0.0189 0 438 N N0.0 135 291 0.0101 0 426 N N0.0 366.3 704.7 0.0201 0 1071 N N1.0 70.9 340.1 0 0.0031 411 N N1.0 310.8 559.2 0.0167 0.0016 870 N N4.2 311 616 0.0229 0.0057 927 N N2.8 195.9 467.1 0.0183 0.0048 663 N N5.1 640 1643 0.0199 0.0028 2283 N N3.2 71.1 159.9 0 0.0172 231 N N1.0 254.2 483.8 0.025 0.0017 738 N N1.0 135.7 260.3 0.0124 0.0032 396 N N1.1 135.8 257.2 0.0242 0.0032 393 N N2.1 196.2 526.8 0.0127 0.0036 723 N N5.0 311.5 804.5 0.0163 0.0058 1116 N N6.0 694.2 1945.8 0.0187 0.0029 2640 N N2.0 311.6 867.4 0.0138 0.0023 1179 N N3.1 311.6 747.4 0.0169 0.0037 1059 N N9.2 423.2 1076.8 0.0175 0.0079 1500 N N4.0 311.7 891.3 0.0143 0.0044 1203 N N6.0 586.9 1402.1 0.0207 0.0039 1989 N N6.0 424.3 1360.7 0.0165 0.0042 1785 N N1.0 197.1 624.9 0.0108 0.0016 822 N N6.1 642.1 1364.9 0.0258 0.0038 2007 N N1.0 255.8 572.2 0.0212 0.0016 828 N N3.1 197.4 543.6 0.0158 0.0055 741 N N2.1 137 235 0.0246 0.0069 372 N N0.0 137 253 0.0112 0 390 N N

14.2 1224.1 3542.9 0.0205 0.0038 4767 N N3.0 480.3 1640.7 0.0156 0.0018 2121 N N2.0 197.8 537.2 0.0122 0.0035 735 N N0.0 197.8 675.2 0.0107 0 873 N N0.0 137.2 306.8 0.018 0 444 N N0.0 198 387 0.0225 0 585 N N2.0 257 667 0.0141 0.0028 924 N N6.1 370.8 820.2 0.0191 0.0065 1191 N N4.1 137.9 282.1 0.0112 0.0122 420 N N4.1 257.3 864.7 0.0102 0.0049 1122 N N1.0 138 474 0.0073 0.0021 612 N N6.1 482 982 0.0224 0.0053 1464 N N2.0 198.9 398.1 0.0144 0.0044 597 N N4.2 482.3 861.7 0.0286 0.0038 1344 N N2.0 257.7 582.3 0.0161 0.0031 840 N N9.1 912.6 2690.4 0.019 0.0032 3603 N N1.0 258 765 0.0124 0.0013 1023 N N

2.1 73.2 127.8 0 0.0128 201 N2.1 427.9 871.1 0.0213 0.002 1299 N N1.9 258.3 779.7 0.0129 0.0025 1038 N N4.0 372.3 1091.7 0.016 0.0035 1464 N N7.4 428.1 1011.9 0.0224 0.0063 1440 N N1.0 258.6 743.4 0.0133 0.0013 1002 N N1.0 73.6 112.4 0 0.0067 186 N N2.0 372.7 779.3 0.0196 0.0022 1152 N N7.1 647.3 1647.7 0.02 0.0039 2295 N N8.1 647.4 1626.6 0.0201 0.0045 2274 N N4.1 200.4 579.6 0.0111 0.0067 780 N N7.0 429.2 1067.8 0.0179 0.0061 1497 N N0.0 200.6 477.4 0.0132 0 678 N N1.0 259.8 469.2 0.0208 0.0017 729 N N1.0 756.5 1403.5 0.0251 0.0006 2160 N N3.0 374.1 921.9 0.0175 0.003 1296 N N7.2 485.6 996.4 0.0213 0.0061 1482 N N0.0 74.4 261.6 0 0 336 N N6.2 649.3 1243.7 0.0272 0.0041 1893 N N3.1 140.1 480.9 0.0149 0.0062 621 N N0.0 140.1 501.9 0.0066 0 642 N N5.3 1233.1 3092.9 0.0225 0.0015 4326 N N9.0 375.1 941.9 0.0168 0.0089 1317 N N0.0 140.6 246.4 0.0122 0 387 N N2.1 375.2 713.8 0.0195 0.0024 1089 N N1.1 486.7 1181.3 0.021 0.0008 1668 N N1.0 140.7 312.3 0.008 0.0031 453 N N2.9 542 1225 0.0196 0.0022 1767 N N0.0 261.3 392.7 0.019 0 654 N N6.0 261.7 1109.3 0.0103 0.0056 1371 N N1.0 261.9 650.1 0.0141 0.0014 912 N N1.0 141.4 266.6 0.0094 0.0033 408 N N1.0 75.4 329.6 0 0.0032 405 N N1.0 920.2 2598.8 0.0189 0.0004 3519 N N0.0 75.5 290.5 0 0 366 N N7.3 432.9 956.1 0.0231 0.0065 1389 N N5.1 376.9 784.1 0.0198 0.0055 1161 N N0.0 75.6 233.4 0 0 309 N N1.0 377.1 924.9 0.0164 0.001 1302 N N1.0 377.1 1104.9 0.0161 0.0009 1482 N N3.1 598.5 1615.5 0.0176 0.0018 2214 N N4.9 262.5 520.5 0.0202 0.0074 783 N N0.0 203.4 435.6 0.0202 0 639 N N0.0 142 323 0.0178 0 465 N N7.0 707.4 1995.6 0.019 0.0033 2703 N N5.1 599 1243 0.0216 0.0035 1842 N N4.1 433.8 1270.2 0.0162 0.003 1704 N N3.0 434 1261 0.0157 0.0023 1695 N N2.1 378.2 803.8 0.0226 0.0022 1182 N N6.0 321.4 1052.6 0.0135 0.0056 1374 N N1.0 76.3 139.7 0.0212 0.006 216 N N1.0 76.3 250.7 0 0.004 327 N3.2 378.6 797.4 0.0232 0.0033 1176 N N

2.0 204.5 680.5 0.0104 0.0029 885 N N0.0 76.5 385.5 0 0 462 N N1.1 204.7 380.3 0.0245 0.0022 585 N N9.1 709.8 1933.2 0.0195 0.0044 2643 N N0.0 143.3 279.7 0.021 0 423 N1.0 143.3 285.7 0.0098 0.0031 429 N N7.0 601.5 1678.5 0.0186 0.0039 2280 N N2.1 264.6 614.4 0.022 0.0029 879 N N1.0 491.6 1278.4 0.017 0.0007 1770 N Y

21.7 1242.1 3056.9 0.0226 0.0063 4299 N N2.0 205.2 493.8 0.0139 0.0036 699 N N1.0 264.8 572.2 0.0163 0.0015 837 N N7.0 380.1 990.9 0.0164 0.0066 1371 N N4.2 1349 3025 0.0252 0.0012 4374 N N0.0 77.5 324.5 0 0 402 N N7.0 927 2415 0.0196 0.0027 3342 N N8.1 265.9 760.1 0.0127 0.0102 1026 N N3.0 265.9 739.1 0.0136 0.0038 1005 N N

11.4 820.3 1870.7 0.0241 0.0053 2691 N N3.0 144.4 428.6 0.0075 0.0069 573 N N2.0 658.3 1441.7 0.0201 0.0013 2100 N N4.2 206.4 483.6 0.0191 0.0076 690 N N2.0 437.7 1014.3 0.0178 0.0018 1452 N N4.1 381.5 785.5 0.0251 0.0043 1167 N N4.0 266.2 783.8 0.0129 0.0049 1050 N N1.0 206.7 603.3 0.011 0.0016 810 N N0.0 144.8 584.2 0.0063 0 729 N N1.0 145 365 0.0081 0.0026 510 N N3.0 266.8 618.2 0.0149 0.0044 885 N N0.0 768.2 1523.8 0.0254 0 2292 N N4.1 145.2 379.8 0.0077 0.0102 525 N N0.0 207.4 815.6 0.0089 0 1023 N N5.0 660.2 1736.8 0.0198 0.0027 2397 N N7.2 325.6 862.4 0.015 0.0077 1188 N N0.0 145.5 253.5 0.0182 0 399 N N

11.2 1036.8 2677.2 0.0201 0.0039 3714 N N2.0 439.9 1057.1 0.0194 0.0017 1497 N N2.1 326.1 570.9 0.0202 0.0029 897 N N0.0 78.7 371.3 0 0 450 N N1.0 208.1 712.9 0.0105 0.0014 921 N N0.0 145.9 523.1 0.0064 0 669 N N1.0 78.8 137.2 0 0.0059 216 N2.7 146 319 0.0126 0.0073 465 N N1.0 551.8 1440.2 0.0184 0.0006 1992 N Y3.0 268.3 1093.7 0.01 0.0028 1362 N N6.1 268.3 745.7 0.0119 0.0079 1014 N N3.1 326.7 1053.3 0.0129 0.0028 1380 N N6.2 878.2 2229.8 0.0194 0.0025 3108 N N3.0 268.4 604.6 0.0161 0.0044 873 N N4.3 208.6 472.4 0.0206 0.0075 681 N N0.0 441.1 1133.9 0.0172 0 1575 N N1.0 146.5 360.5 0.0077 0.0027 507 N N1.1 717 1824 0.0193 0.0005 2541 N N

5.9 932.6 2580.4 0.0189 0.0022 3513 N N3.1 327.3 659.7 0.0186 0.0039 987 N N1.0 209 367 0.014 0.0023 576 N N0.0 79.5 157.5 0.0196 0 237 N N

10.6 327.8 719.2 0.0199 0.0127 1047 N N3.1 327.8 641.2 0.0241 0.004 969 N N4.1 269.4 765.6 0.0122 0.0051 1035 N N1.0 147 453 0.0076 0.0021 600 N N0.0 209.5 381.5 0.0159 0 591 N N4.1 385.8 829.2 0.0189 0.0042 1215 N N2.1 442.5 1096.5 0.0166 0.0017 1539 N N2.9 328.6 1051.4 0.0123 0.0029 1380 N N0.0 80 385 0 0 465 N N2.0 80.1 171.9 0 0.0102 252 N N4.2 328.9 595.1 0.0254 0.0055 924 N N0.0 147.7 338.3 0.0096 0 486 N N8.1 443.2 1440.8 0.0156 0.0054 1884 N N2.0 443.4 960.6 0.0193 0.0018 1404 N N

12.1 774.2 1922.8 0.0205 0.0057 2697 N N1.1 148 329 0.019 0.0027 477 N N2.1 210.8 320.2 0.0268 0.0048 531 N N3.1 387.3 1130.7 0.0145 0.0026 1518 N Y4.9 387.3 1199.7 0.0138 0.0041 1587 N N

10.2 500.7 1242.3 0.0187 0.0074 1743 N N13.3 883.9 2113.1 0.0206 0.0057 2997 N N

3.0 271.7 688.3 0.0187 0.004 960 N N0.0 80.9 312.1 0 0 393 N N2.0 445.2 1270.8 0.0156 0.0015 1716 N N5.1 330.8 803.2 0.0162 0.0057 1134 N N2.1 388.5 982.5 0.0158 0.0019 1371 N N0.0 211.9 748.1 0.0088 0 960 N N6.2 612.9 1466.1 0.0221 0.0037 2079 N N2.1 445.8 1213.2 0.016 0.0016 1659 N N2.0 502.1 1333.9 0.0167 0.0014 1836 N N0.0 389 733 0.0203 0 1122 N N4.0 331.3 1135.7 0.0127 0.0035 1467 N N2.0 502.7 1108.3 0.0187 0.0016 1611 N N2.0 331.8 1069.2 0.0123 0.0019 1401 N Y

11.2 886.5 2437.5 0.0192 0.0043 3324 N N0.0 81.7 482.3 0 0 564 N N1.0 150.2 485.8 0.0072 0.002 636 N N1.0 150.2 518.8 0.0069 0.0019 669 N N

15.4 887.7 2112.3 0.0231 0.0064 3000 N N0.0 779.7 1833.3 0.0196 0 2613 N N0.0 82.2 232.8 0 0 315 N N1.1 150.5 293.5 0.0203 0.0029 444 N N1.0 333.2 572.8 0.0215 0.0014 906 N N3.0 615.9 1589.1 0.018 0.0018 2205 N N8.0 333.3 1163.7 0.0122 0.0069 1497 N N

12.4 1050 2592 0.0203 0.0043 3642 N N4.0 835.1 1894.9 0.0199 0.0019 2730 N N4.0 671.7 1263.3 0.0254 0.0026 1935 N N4.0 214.4 703.6 0.0096 0.0057 918 N N

3.1 727.3 1708.7 0.0207 0.0016 2436 N N4.1 449.4 1167.6 0.0154 0.0033 1617 N N8.0 334.4 1060.6 0.0133 0.0074 1395 N N4.1 449.6 873.4 0.0197 0.004 1323 N N2.1 392.5 786.5 0.0226 0.0022 1179 N N9.1 727.9 1792.1 0.0208 0.0046 2520 N N2.0 392.7 1302.3 0.0136 0.0015 1695 N N3.1 506.6 1143.4 0.0197 0.0023 1650 N N0.0 151.9 319.1 0.008 0 471 N N8.1 450.2 1061.8 0.0192 0.0067 1512 N N3.2 1686.7 3983.3 0.0225 0.0007 5670 N N1.9 83.3 249.7 0 0.008 333 N N6.3 837.4 2234.6 0.0197 0.0026 3072 N N2.1 215.3 303.7 0.0175 0.005 519 N N2.1 152 358 0.0176 0.0051 510 N N1.1 563.2 1350.8 0.0199 0.0007 1914 N N2.0 152.2 405.8 0.008 0.0046 558 N N2.0 619.1 1321.9 0.0197 0.0014 1941 N N1.0 393.8 983.2 0.0155 0.001 1377 N Y0.0 152.5 306.5 0.0197 0 459 N N

11.1 838.7 2221.3 0.0196 0.0046 3060 N N0.0 83.8 282.2 0 0 366 N N4.2 674.9 1602.1 0.0223 0.0023 2277 N N0.0 216.2 467.8 0.0206 0 684 N N4.1 564.4 1277.6 0.0192 0.0028 1842 N Y0.0 84 273 0 0 357 N N1.1 336.4 890.6 0.0139 0.0011 1227 N N5.1 452 1123 0.0211 0.004 1575 N N0.0 277.5 694.5 0.013 0 972 N N4.1 395.3 1158.7 0.0152 0.0033 1554 N N0.0 278 538 0.0172 0 816 N N4.1 153.6 362.4 0.009 0.01 516 N N3.1 217.2 547.8 0.0175 0.0051 765 N N7.1 566.2 1170.8 0.0211 0.0052 1737 N N3.0 278.9 1005.1 0.0106 0.003 1284 N N0.0 85.1 445.9 0 0 531 N N7.2 678.5 1763.5 0.0211 0.0037 2442 N N2.0 338.7 870.3 0.016 0.0021 1209 N N3.0 397.2 970.8 0.0161 0.0029 1368 N N3.0 454.7 1198.3 0.0167 0.0023 1653 N N0.0 279.6 896.4 0.0114 0 1176 N N3.1 218.5 555.5 0.0182 0.005 774 N N3.0 511.7 1219.3 0.0221 0.0022 1731 N N0.0 218.8 513.2 0.0176 0 732 N N1.0 280.3 493.7 0.0186 0.0016 774 N N2.0 280.4 727.6 0.013 0.0026 1008 N N1.0 456 1257 0.0156 0.0008 1713 N Y5.0 569.3 1911.7 0.0144 0.0026 2481 N N0.0 280.6 538.4 0.022 0 819 N N7.1 340.3 664.7 0.023 0.009 1005 N N7.1 513.3 1730.7 0.0148 0.004 2244 N N5.0 513.6 1442.4 0.0161 0.0033 1956 N N2.0 340.8 565.2 0.02 0.0028 906 N N

10.2 513.9 1157.1 0.0196 0.0077 1671 N N10.2 513.9 1157.1 0.0196 0.0077 1671 N N

2.1 457 1025 0.017 0.0018 1482 N N7.0 457.3 1342.7 0.0161 0.0049 1800 N N2.0 156.3 392.7 0.0177 0.0046 549 N N0.0 457.6 886.4 0.0236 0 1344 N N0.0 156.4 287.6 0.0098 0 444 N N0.0 156.8 302.2 0.0088 0 459 N N2.1 515.3 1371.7 0.0171 0.0014 1887 N N4.1 156.9 383.1 0.0165 0.0096 540 N N0.0 87.1 263.9 0 0 351 N N2.1 400.8 880.2 0.0158 0.0021 1281 N N3.1 515.6 1182.4 0.0192 0.0023 1698 N N1.0 157 440 0.007 0.0022 597 N N0.0 87.3 311.7 0 0 399 N N3.0 516.1 1310.9 0.0174 0.0021 1827 N N1.0 221.5 603.5 0.0106 0.0016 825 N N3.0 342.9 893.1 0.0145 0.0031 1236 N N1.0 516.6 1232.4 0.0167 0.0008 1749 N N0.0 87.6 224.4 0 0 312 N N1.0 401.9 1086.1 0.0147 0.0009 1488 N N2.0 157.7 547.3 0.006 0.0037 705 N N5.1 516.9 1196.1 0.0179 0.0038 1713 N N4.0 222.2 575.8 0.0118 0.0064 798 N N0.0 157.9 298.1 0.0113 0 456 N N4.0 343.7 889.3 0.0142 0.0042 1233 N N0.0 460.3 1165.7 0.0162 0 1626 N Y0.0 88 173 0.0177 0 261 N N3.1 158.2 387.8 0.0164 0.0071 546 N N4.2 402.8 782.2 0.0221 0.0044 1185 N N6.1 158.3 408.7 0.0073 0.0141 567 N N0.0 284.4 651.6 0.0182 0 936 N N5.0 284.4 699.6 0.0132 0.0067 984 N N0.0 284.4 462.6 0.0177 0 747 N N3.0 158.4 582.6 0.0055 0.0054 741 N N0.0 344.8 753.2 0.0181 0 1098 N N4.1 461.7 1059.3 0.0179 0.0034 1521 N N8.2 403.9 883.1 0.0178 0.008 1287 N N6.0 688.1 1366.9 0.0227 0.0037 2055 N N0.0 223.8 394.2 0.0168 0 618 N N4.0 159.3 362.7 0.0087 0.0099 522 N N

29.7 1232.4 3159.6 0.0199 0.0086 4392 N N1.1 345.9 704.1 0.0215 0.0012 1050 N N0.0 346 686 0.0182 0 1032 N N

10.3 576.8 1631.2 0.0207 0.0057 2208 N N5.0 633.4 1727.6 0.0168 0.0028 2361 N N6.0 577.2 1756.8 0.0159 0.0033 2334 N N7.3 346.4 817.6 0.0198 0.0077 1164 N N5.2 346.5 1000.5 0.0164 0.0048 1347 N N8.1 577.4 1249.6 0.0244 0.0055 1827 N N2.1 159.9 257.1 0.0222 0.0062 417 N N2.9 286.6 787.4 0.0132 0.0036 1074 N N4.0 286.6 721.4 0.0135 0.0051 1008 N N

3.0 347 679 0.0177 0.0038 1026 N N0.0 89.7 174.3 0.0151 0 264 N N3.0 89.7 168.3 0 0.0151 258 N1.0 287 703 0.0129 0.0013 990 N N4.1 225.2 467.8 0.0122 0.0076 693 N N1.0 225.3 614.7 0.015 0.0016 840 N N5.0 160.6 598.4 0.0063 0.0084 759 N N2.1 160.7 232.3 0.0216 0.0067 393 N N1.0 90.1 164.9 0 0.0052 255 N0.0 160.9 331.1 0.0175 0 492 N0.0 90.2 167.8 0.0186 0 258 N N0.0 579.5 1403.5 0.0193 0 1983 N N1.1 523 1811 0.0136 0.0006 2334 N N4.1 288.2 566.8 0.0161 0.006 855 N N7.0 465.7 1631.3 0.0141 0.0042 2097 N N2.0 407.6 1065.4 0.0162 0.0017 1473 N N0.0 161.4 309.6 0.0099 0 471 N N0.0 90.6 356.4 0 0 447 N N8.2 692.7 1641.3 0.0188 0.0045 2334 N N5.0 348.9 878.1 0.0145 0.0053 1227 N N3.1 348.9 791.1 0.0158 0.0034 1140 N N4.0 288.6 740.4 0.018 0.005 1029 N N1.0 288.7 887.3 0.0112 0.0011 1176 N N4.0 408.2 1034.8 0.014 0.0037 1443 N N0.0 581.2 1170.8 0.02 0 1752 N N

15.2 1185.8 3239.2 0.0189 0.0044 4425 N N3.1 581.5 1926.5 0.0155 0.0015 2508 N N0.0 162.2 320.8 0.0101 0 483 N N0.0 91.2 517.8 0 0 609 N N1.0 91.3 181.7 0 0.0047 273 N N7.2 289.7 637.3 0.0147 0.0098 927 N Y7.1 638.5 1488.5 0.0198 0.0042 2127 N N1.1 350.4 702.6 0.0184 0.0012 1053 N N2.0 1026.1 2483.9 0.0195 0.0007 3510 N N4.2 468.8 1055.2 0.0179 0.0034 1524 N N1.1 583.7 1555.3 0.0165 0.0006 2139 N N0.0 92.1 228.9 0 0 321 N N1.0 92.1 219.9 0 0.004 312 N N3.1 918.2 1946.8 0.0236 0.0014 2865 N N0.0 92.3 405.7 0 0 498 N6.0 584.4 1590.6 0.0167 0.0036 2175 N N7.1 527.6 1506.4 0.0162 0.0044 2034 N N5.9 641.5 1908.5 0.0165 0.003 2550 N N1.0 92.6 402.4 0 0.0026 495 N N3.0 92.7 210.3 0 0.0128 303 N N0.0 229.6 433.4 0.0199 0 663 N N0.0 352.7 604.3 0.0204 0 957 N N1.0 164.3 303.7 0.011 0.0027 468 N N1.0 92.8 465.2 0 0.0023 558 N N5.0 528.6 1322.4 0.016 0.0036 1851 N N7.6 292.7 667.3 0.0159 0.0102 960 N N1.0 164.8 573.2 0.0062 0.0017 738 N N0.0 93.3 170.7 0.0153 0 264 N N

4.2 230.5 612.5 0.0152 0.0062 843 N N0.0 230.5 426.5 0.0206 0 657 N N1.0 230.5 441.5 0.0146 0.0019 672 N N8.3 472.1 1051.9 0.0205 0.0068 1524 N N1.0 93.5 242.5 0 0.0038 336 N N8.1 644 1684 0.0167 0.0045 2328 N N8.1 644 1684 0.0167 0.0045 2328 N N3.1 530.2 1194.8 0.0204 0.0023 1725 N N8.5 354.6 734.4 0.021 0.0095 1089 N N2.1 354.6 857.4 0.015 0.0021 1212 N N3.1 472.7 946.3 0.0226 0.0027 1419 N N

15.1 644.5 1989.5 0.0154 0.0074 2634 N N4.1 414.4 938.6 0.0216 0.0037 1353 N N0.0 1087.4 2425.6 0.0208 0 3513 N N3.0 232 548 0.0117 0.0049 780 N N1.0 355.6 901.4 0.0143 0.001 1257 N N6.1 869 1900 0.0209 0.0028 2769 N N2.0 355.9 850.1 0.0154 0.0021 1206 N N2.1 94.5 412.5 0.0086 0.0051 507 N N2.1 415.6 1087.4 0.015 0.0017 1503 N N6.1 295.1 772.9 0.0175 0.0072 1068 N N1.0 589.6 1666.4 0.0158 0.0006 2256 N N1.0 295.3 724.7 0.0173 0.0013 1020 N N5.0 870.8 1934.2 0.0219 0.0023 2805 N N

15.0 591.1 1763.9 0.0157 0.0082 2355 N N6.1 475.8 1210.2 0.0152 0.0047 1686 N N2.0 233.5 531.5 0.0098 0.0036 765 N N

10.2 357.6 794.4 0.0163 0.0112 1152 N1.1 704.8 1500.2 0.0201 0.0006 2205 N N4.0 761.1 2019.9 0.0186 0.0018 2781 N N2.0 167.9 456.1 0.0065 0.0043 624 N N8.1 534.7 1307.3 0.0183 0.0055 1842 N N4.1 297.1 677.9 0.0127 0.0054 975 N N0.0 234.2 452.8 0.0192 0 687 N N2.1 95.8 180.2 0.0152 0.0096 276 N N0.0 95.9 426.1 0 0 522 N N0.0 95.9 477.1 0 0 573 N2.0 168.4 392.6 0.0173 0.0045 561 N N2.0 234.6 611.4 0.0102 0.0031 846 N N1.0 358.8 667.2 0.0175 0.0013 1026 N N2.1 234.7 650.3 0.0144 0.003 885 N N3.0 297.9 770.1 0.0125 0.0036 1068 N N0.0 477.8 935.2 0.0204 0 1413 N N0.0 168.8 329.2 0.0089 0 498 N N1.0 359.2 939.8 0.0174 0.001 1299 N N3.1 359.2 774.8 0.0162 0.0034 1134 N N4.1 419.9 1023.1 0.0153 0.0036 1443 N N5.1 298.9 751.1 0.013 0.0061 1050 N N

11.9 651.9 1958.1 0.0166 0.0058 2610 N N0.0 96.9 335.1 0 0 432 N N0.0 96.9 392.1 0 0 489 N N3.2 479.5 1068.5 0.0195 0.0025 1548 N N1.0 169.8 331.2 0.0088 0.0026 501 N N

0.0 97.1 328.9 0 0 426 N N1.0 97.1 484.9 0 0.0022 582 N N1.0 236.4 474.6 0.0192 0.0018 711 N N0.0 170.1 321.9 0.0082 0 492 N N2.0 299.7 1275.3 0.0087 0.0016 1575 N N0.0 361.1 712.9 0.0165 0 1074 N N1.0 299.8 648.2 0.0179 0.0014 948 N N1.0 236.6 570.4 0.0108 0.0016 807 N N9.2 654 1581 0.0183 0.0052 2235 N N5.0 300.6 1355.4 0.0084 0.0039 1656 N N0.0 362.1 999.9 0.0133 0 1362 N N4.0 597.2 1187.8 0.0239 0.0029 1785 N N2.0 481.3 1102.7 0.0165 0.0016 1584 N N0.0 98 193 0.0146 0 291 N N3.1 481.6 1006.4 0.0173 0.0026 1488 N N4.1 171.2 413.8 0.0082 0.0087 585 N N5.2 362.6 726.4 0.0224 0.0058 1089 N N3.0 423.2 896.8 0.0162 0.003 1320 N N3.0 171.6 383.4 0.0088 0.0068 555 N N3.1 171.8 389.2 0.0172 0.0068 561 N Y

14.7 880.9 2008.1 0.0209 0.0065 2889 N N7.9 881.1 2337.9 0.0187 0.0032 3219 N N3.0 302.2 729.8 0.0128 0.0038 1032 N N2.1 98.8 219.2 0 0.008 318 N N5.9 599.4 1908.6 0.0142 0.0031 2508 N N1.0 238.8 433.2 0.0149 0.0019 672 N N2.1 172.2 466.8 0.0146 0.004 639 N N4.1 424.3 886.7 0.0175 0.0039 1311 N N2.0 302.6 819.4 0.0126 0.0023 1122 N N0.0 172.5 424.5 0.0151 0 597 N N8.3 364.5 694.5 0.0231 0.0096 1059 N N1.0 364.6 916.4 0.0143 0.001 1281 N N2.1 425.1 939.9 0.0161 0.0019 1365 N Y0.0 303.2 572.8 0.0158 0 876 N N6.9 771.3 1928.7 0.0187 0.0033 2700 N N3.1 771.5 1721.5 0.0213 0.0015 2493 N N1.0 173 316 0.0198 0.0026 489 N N7.1 365.3 972.7 0.0136 0.0068 1338 N Y3.0 173.2 645.8 0.0057 0.0047 819 N N1.0 426 903 0.0169 0.001 1329 N N1.0 100 227 0.0138 0.004 327 N N0.0 100 347 0 0 447 N N2.0 173.6 408.4 0.0167 0.0043 582 N N6.3 173.6 384.4 0.0149 0.0143 558 N N1.0 366 972 0.0138 0.001 1338 N N2.0 173.8 519.2 0.0068 0.0037 693 N N0.0 773.3 2121.7 0.0171 0 2895 N N3.0 426.9 1208.1 0.014 0.0024 1635 N N1.0 304.8 799.2 0.011 0.0012 1104 N Y3.0 427.1 889.9 0.018 0.0029 1317 N N6.1 304.9 679.1 0.0191 0.0078 984 N N1.0 241.2 529.8 0.0178 0.0017 771 N N0.0 305 973 0.0103 0 1278 N N

7.9 774.2 2123.8 0.018 0.0035 2898 N N3.1 831 1611 0.0252 0.0016 2442 N N3.1 428.1 1185.9 0.0146 0.0024 1614 N N6.1 367.7 934.3 0.0142 0.0059 1302 N N4.0 662.2 1596.8 0.0182 0.0023 2259 N N0.0 242.7 468.3 0.0187 0 711 N N0.0 101.5 291.5 0 0 393 N N0.0 242.8 495.2 0.0118 0 738 N N3.2 101.6 180.4 0 0.0134 282 N1.0 242.9 486.1 0.0197 0.0017 729 N N1.0 430.1 1021.9 0.0152 0.0009 1452 N N0.0 102 234 0.0136 0 336 N N0.0 307.5 547.5 0.0217 0 855 N N2.0 430.4 1525.6 0.0115 0.0013 1956 N N1.0 176.4 333.6 0.0086 0.0026 510 N N3.0 490.2 1264.8 0.0154 0.0022 1755 N N1.0 176.6 492.4 0.0063 0.002 669 N N

11.1 549.3 1481.7 0.0162 0.0069 2031 N N0.0 176.8 339.2 0.008 0 516 N N5.2 431.2 921.8 0.0197 0.0048 1353 N N9.1 891.7 2267.3 0.0185 0.0037 3159 N N1.0 244.4 673.6 0.0088 0.0015 918 N N1.0 491.1 996.9 0.0182 0.0009 1488 N N0.0 177.1 269.9 0.0226 0 447 N N5.2 550.4 1186.6 0.0216 0.0037 1737 N N3.1 431.9 909.1 0.0152 0.003 1341 N N1.0 371.2 681.8 0.018 0.0012 1053 N N8.3 608.7 1335.3 0.021 0.0053 1944 N N

14.4 432.1 980.9 0.0152 0.0131 1413 N1.0 491.8 1020.2 0.0202 0.0009 1512 N N1.0 103.1 247.9 0.0137 0.0036 351 N N0.0 309.3 1019.7 0.0104 0 1329 N N8.0 551.1 1635.9 0.015 0.0047 2187 N N1.0 551.3 1263.7 0.0178 0.0007 1815 N N0.0 781.2 1792.8 0.0188 0 2574 N N5.1 609.8 1382.2 0.0179 0.0033 1992 N N6.1 372.1 893.9 0.0148 0.0061 1266 N N1.0 103.6 442.4 0.0086 0.0023 546 N N1.0 178.2 598.8 0.0055 0.0017 777 N N0.0 310.2 1189.8 0.0093 0 1500 N N0.0 246 504 0.0185 0 750 N N5.1 310.5 772.5 0.013 0.0059 1083 N N0.0 178.7 292.3 0.0098 0 471 N N5.0 494 1261 0.0155 0.0037 1755 N Y0.0 179 334 0.0164 0 513 N N2.0 311.2 780.8 0.0166 0.0024 1092 N N0.0 104.4 336.6 0 0 441 N N2.1 104.6 231.4 0 0.0078 336 N N

20.2 554.3 1194.7 0.0146 0.0152 1749 N N20.2 554.3 1194.7 0.0146 0.0152 1749 N N

7.4 1339.1 3196.9 0.0204 0.002 4536 N N1.0 436.1 1411.9 0.0125 0.0007 1848 N N0.0 105.2 176.8 0.0165 0 282 N N

1.1 105.8 209.2 0 0.0041 315 N N0.0 376.3 850.7 0.0146 0 1227 N N0.0 437.5 1326.5 0.0119 0 1764 N N6.2 106 260 0.0121 0.0215 366 N N2.0 557.2 1359.8 0.0176 0.0013 1917 N N2.0 376.8 964.2 0.0133 0.0019 1341 N N1.0 438 855 0.0203 0.001 1293 N N

15.2 957.3 2582.7 0.0186 0.0054 3540 N N2.0 106.3 211.7 0 0.0082 318 N N2.1 498.4 1094.6 0.0176 0.0016 1593 N N9.0 845.3 2574.7 0.0162 0.0034 3420 N N0.0 182 376 0.0166 0 558 N N3.1 558.4 1538.6 0.0152 0.0018 2097 N N6.1 315.5 704.5 0.0133 0.0076 1020 N N1.0 182.4 414.6 0.0074 0.0022 597 N N1.0 250.8 733.2 0.0095 0.0013 984 N N7.9 439.7 1441.3 0.0122 0.0055 1881 N N7.0 316.1 1024.9 0.01 0.0068 1341 N N3.0 440.3 1026.7 0.0157 0.0026 1467 N N0.0 183.3 341.7 0.009 0 525 N N2.1 441 1026 0.0141 0.0018 1467 N N9.3 1128.7 3317.3 0.018 0.0026 4446 N N0.0 107.9 258.1 0.0123 0 366 N N0.0 107.9 225.1 0.0126 0 333 N N1.0 317.2 783.8 0.0116 0.0012 1101 N N2.1 184.2 472.8 0.0127 0.004 657 N0.0 184.2 397.8 0.0169 0 582 N N2.0 318 840 0.0118 0.0022 1158 N N3.0 442.5 946.5 0.0159 0.0028 1389 N N6.1 442.6 892.4 0.0213 0.0057 1335 N N0.0 184.7 478.3 0.0123 0 663 N N3.0 253.5 574.5 0.01 0.0048 828 N N0.0 184.9 442.1 0.0137 0 627 N N1.0 184.9 586.1 0.0059 0.0017 771 N N4.1 381.8 956.2 0.0137 0.0038 1338 N N1.0 109 197 0 0.0043 306 N N8.7 563.4 1077.6 0.0209 0.0067 1641 N N1.9 563.5 1296.5 0.0172 0.0014 1860 N N0.0 319.3 802.7 0.0118 0 1122 N N0.0 254.1 495.9 0.012 0 750 N N0.0 185.4 429.6 0.0137 0 615 N N6.0 504.5 1367.5 0.0145 0.0041 1872 N N4.0 319.5 877.5 0.0122 0.0042 1197 N N0.0 109.4 397.6 0 0 507 N N1.0 444.2 1202.8 0.014 0.0008 1647 N N1.1 623.7 1356.3 0.0192 0.0006 1980 N N1.0 444.8 1016.2 0.0186 0.0009 1461 N N

18.5 911 2278 0.016 0.0076 3189 N N0.0 186.2 353.8 0.0176 0 540 N N1.0 505.7 1405.3 0.0134 0.0007 1911 N N3.1 110 226 0.0121 0.012 336 N N1.0 255.2 566.8 0.0099 0.0016 822 N N0.0 110.2 318.8 0 0 429 N N

11.1 384 1374 0.0102 0.0081 1758 N N1.0 507.2 1607.8 0.0133 0.0006 2115 N N0.0 187.4 307.6 0.0189 0 495 N N7.1 684.7 1619.3 0.0178 0.0039 2304 N N3.0 256.7 592.3 0.0179 0.0044 849 N N3.0 508 1322 0.0142 0.0021 1830 N N5.1 1414 2843 0.0241 0.0015 4257 N N0.0 508.1 1600.9 0.0129 0 2109 N N9.2 857.8 2250.2 0.0192 0.0037 3108 N N0.0 385.8 1069.2 0.0119 0 1455 N N0.0 257.2 474.8 0.0187 0 732 N N0.0 257.2 1017.8 0.0071 0 1275 N N1.0 188.1 612.9 0.0058 0.0016 801 N N5.1 686 1390 0.0194 0.0031 2076 N N1.0 111.6 221.4 0 0.004 333 N7.2 448.7 1108.3 0.0168 0.0059 1557 N N0.0 323.7 681.3 0.0131 0 1005 N N0.0 509.8 945.2 0.019 0 1455 N N3.1 188.9 348.1 0.0176 0.0071 537 N N6.1 323.9 840.1 0.0135 0.007 1164 N Y9.2 510.1 1271.9 0.0151 0.0066 1782 N N1.1 324.1 641.9 0.0181 0.0013 966 N N6.2 746.1 1578.9 0.0189 0.0034 2325 N N3.0 258.9 620.1 0.011 0.0043 879 N N0.0 189.6 350.4 0.0086 0 540 N7.1 325 830 0.0125 0.0077 1155 N N2.0 630.8 1439.2 0.0171 0.0013 2070 N N2.0 113.1 279.9 0 0.0066 393 N N2.1 512 1102 0.0163 0.0016 1614 N Y0.0 190.4 364.6 0.0171 0 555 N N2.0 325.8 835.2 0.0117 0.0022 1161 N N4.1 325.8 700.2 0.0143 0.0049 1026 N N1.0 572.4 1131.6 0.0215 0.0008 1704 N N0.0 261 630 0.0153 0 891 N N9.0 1092.4 2915.6 0.018 0.0029 4008 N N0.0 192 291 0.0177 0 483 N N0.0 261.8 350.2 0.014 0 612 N N8.1 328 782 0.0127 0.0092 1110 N N4.1 262.5 595.5 0.0162 0.006 858 N N1.0 328.7 649.3 0.014 0.0013 978 N N0.0 192.8 368.2 0.0167 0 561 N N3.1 328.9 739.1 0.0173 0.0036 1068 N N0.0 115.4 247.6 0.0136 0 363 N N0.0 455.5 1209.5 0.0137 0 1665 N N1.1 329.6 624.4 0.0189 0.0014 954 N Y0.0 193.6 394.4 0.0072 0 588 N N4.1 456.7 1019.3 0.0182 0.0035 1476 N N1.0 578.3 1155.7 0.0189 0.0007 1734 N N0.0 116.3 489.7 0 0 606 N N0.0 116.4 456.6 0 0 573 N N0.0 116.5 222.5 0.0139 0 339 N N

16.3 1813.2 4648.8 0.0206 0.0032 6462 N N2.2 194.6 273.4 0.0181 0.0056 468 N N

6.2 395.5 1284.5 0.013 0.0047 1680 N N5.1 395.7 885.3 0.0144 0.005 1281 N N7.0 331.8 763.2 0.0128 0.0082 1095 N N7.2 580.6 1237.4 0.0199 0.005 1818 N N1.1 117.4 245.6 0.0113 0.0037 363 N N4.3 459 1191 0.0147 0.0035 1650 N N6.8 266.2 588.8 0.0138 0.0097 855 N N1.0 266.3 483.7 0.0118 0.0017 750 N N2.0 641.1 1566.9 0.016 0.0012 2208 N N0.0 117.8 236.2 0.0127 0 354 N N0.0 196.3 367.7 0.0081 0 564 N N2.0 267.4 881.6 0.0076 0.0023 1149 N N3.0 461.6 1509.4 0.0116 0.002 1971 N N0.0 118.9 187.1 0.0151 0 306 N N8.2 268.1 664.9 0.0098 0.0111 933 N N6.1 702.9 1523.1 0.0182 0.0035 2226 N N2.0 197.6 579.4 0.0056 0.0034 777 N N1.0 268.2 514.8 0.0115 0.0016 783 N N5.6 335.1 939.9 0.0123 0.0056 1275 N N4.0 644.2 1605.8 0.0167 0.0023 2250 N N1.0 119.3 225.7 0.0126 0.0038 345 N N0.0 119.4 372.6 0.008 0 492 N N2.0 400 950 0.0181 0.0019 1350 N N1.1 198.2 335.8 0.0178 0.0024 534 N N6.0 878.7 2235.3 0.0176 0.0025 3114 N N1.0 119.8 570.2 0 0.0019 690 N N3.0 400.6 880.4 0.0138 0.003 1281 N N0.0 198.6 389.4 0.0128 0 588 N N2.0 336.4 911.6 0.0107 0.0021 1248 N N0.0 120.1 257.9 0.011 0 378 N N0.0 199.2 418.8 0.0136 0 618 N2.2 120.4 239.6 0 0.0072 360 N N6.1 401.7 906.3 0.0144 0.0059 1308 N N4.0 270.4 800.6 0.0083 0.0048 1071 N N1.0 120.7 305.3 0 0.003 426 N N3.2 120.8 266.2 0.012 0.01 387 N N1.9 337.7 973.3 0.0097 0.002 1311 N Y2.1 465.3 1094.7 0.0136 0.0017 1560 N4.1 1053.6 2537.4 0.0187 0.0014 3591 N N0.0 338.2 645.8 0.0188 0 984 N N

39.8 1334.9 3489.1 0.0183 0.0106 4824 N N11.2 528.3 1304.7 0.0144 0.0078 1833 N N

0.0 200.7 393.3 0.0068 0 594 N N1.0 403.8 1006.2 0.0126 0.0009 1410 N N3.1 403.9 913.1 0.0167 0.003 1317 N N2.1 589.6 1717.4 0.0138 0.0011 2307 N N1.0 529.2 940.8 0.0224 0.0009 1470 N N1.0 122.1 258.9 0.0123 0.0033 381 N N2.1 201.5 398.5 0.0147 0.0043 600 N N7.5 650.6 1263.4 0.0218 0.0047 1914 N N1.0 273.1 794.9 0.0081 0.0012 1068 N N1.0 122.6 207.4 0.0151 0.0038 330 N N0.0 273.3 542.7 0.0168 0 816 N N

0.0 122.7 231.3 0.0132 0 354 N N13.5 886.3 1879.7 0.0226 0.006 2766 N N

0.0 274.2 535.8 0.0165 0 810 N N3.0 341.6 996.4 0.0102 0.0029 1338 N N6.0 771.5 2063.5 0.0193 0.0027 2835 N N3.1 406.9 961.1 0.0123 0.0029 1368 N N0.0 123.7 251.3 0.0125 0 375 N N2.0 123.7 377.3 0 0.0051 501 N N3.0 532.7 1603.3 0.0128 0.0018 2136 N N0.0 203.7 381.3 0.015 0 585 N N1.1 203.8 384.2 0.0147 0.0022 588 N N7.1 594.4 1442.6 0.0161 0.0044 2037 N N1.0 204 531 0.0056 0.0018 735 N N3.2 204.2 386.8 0.0159 0.0065 591 N N4.4 275.8 501.2 0.0165 0.0068 777 N N0.0 343.4 997.6 0.0095 0 1341 N N1.0 343.5 868.5 0.0113 0.0011 1212 N N4.1 343.6 946.4 0.0103 0.004 1290 N N

12.1 204.7 734.3 0.0051 0.0163 939 N N5.4 409.6 781.4 0.0185 0.0055 1191 N N2.0 596.6 1863.4 0.0127 0.0011 2460 N N7.2 596.8 1527.2 0.0175 0.0042 2124 N N2.0 410.2 996.8 0.0134 0.0018 1407 N N2.0 410.6 810.4 0.0148 0.0021 1221 N N1.1 345.5 710.5 0.0181 0.0012 1056 N N3.1 835.9 2044.1 0.0175 0.0013 2880 N N7.3 206.4 516.6 0.0119 0.0127 723 N N0.0 126.3 389.7 0 0 516 N N1.1 411.7 1325.3 0.0103 0.0007 1737 N N1.0 346.4 640.6 0.0185 0.0013 987 N N4.0 346.6 697.4 0.0127 0.005 1044 N N1.0 126.7 647.3 0 0.0016 774 N N6.3 475.8 949.2 0.0166 0.0054 1425 N N0.0 207.4 359.6 0.0158 0 567 N N0.0 127.1 247.9 0.0127 0 375 N N1.0 207.6 416.4 0.0151 0.002 624 N N0.0 413 931 0.013 0 1344 N N4.0 127.3 316.7 0 0.0121 444 N N

13.1 539.7 1350.3 0.0136 0.0091 1890 N N2.0 208.6 511.4 0.0059 0.0036 720 N7.2 782.1 1938.9 0.0177 0.0033 2721 N N3.0 349.3 1003.7 0.0103 0.0028 1353 N Y1.0 414.9 1133.1 0.0112 0.0008 1548 N N2.1 281.3 519.7 0.0168 0.0032 801 N N3.0 209.3 690.7 0.0048 0.0044 900 N N1.0 128.6 309.4 0.0101 0.003 438 N N6.2 603.7 1451.3 0.0175 0.0038 2055 N N2.1 542.4 1377.6 0.0135 0.0014 1920 N N0.0 350.6 666.4 0.013 0 1017 N N

16.1 350.8 903.2 0.0128 0.016 1254 N N2.0 350.8 849.2 0.0109 0.0022 1200 N N2.1 416.8 804.2 0.0156 0.0021 1221 N N2.1 210.7 395.3 0.0122 0.0046 606 N N

1.9 129.7 299.3 0 0.0063 429 N N0.0 129.7 464.3 0 0 594 N N1.0 129.8 569.2 0 0.0018 699 N2.0 544.7 1267.3 0.0144 0.0014 1812 N N5.1 787.2 1714.8 0.0206 0.0026 2502 N N2.0 130.5 634.5 0 0.0033 765 N N7.1 727.9 1978.1 0.0147 0.0034 2706 N N4.1 353.2 642.8 0.0195 0.0051 996 N N4.0 353.3 996.7 0.0097 0.0039 1350 N N1.1 353.4 627.6 0.0187 0.0013 981 N N0.0 131.1 291.9 0.0108 0 423 N N4.0 419.8 1275.2 0.0113 0.003 1695 N8.0 546.9 1598.1 0.0125 0.0048 2145 N N0.0 670.3 1273.7 0.0206 0 1944 N Y3.1 132 345 0.0088 0.0083 477 N N0.0 213.6 419.4 0.0145 0 633 N N3.1 213.6 404.4 0.0069 0.0064 618 N N2.0 132.1 206.9 0 0.0074 339 N N4.9 791 1972 0.0157 0.0024 2763 N N5.2 671.2 1986.8 0.014 0.0024 2658 N N5.1 850.3 2104.7 0.0185 0.0022 2955 N N5.0 286.7 496.3 0.0108 0.0084 783 N N0.0 355.9 775.1 0.0154 0 1131 N N1.0 356.2 1206.8 0.0084 0.0008 1563 N N0.0 132.8 242.2 0.0118 0 375 N N0.0 132.8 488.2 0 0 621 N N0.0 287.5 633.5 0.0144 0 921 N N0.0 287.5 579.5 0.0149 0 867 N N3.1 549.8 1070.2 0.0172 0.0024 1620 N N1.0 356.6 579.4 0.0155 0.0015 936 N N2.0 487.4 931.6 0.0166 0.0018 1419 N N6.2 215.1 399.9 0.0074 0.0126 615 N N4.1 215.3 519.7 0.0061 0.007 735 N N2.0 215.5 498.5 0.0061 0.0037 714 N N0.0 215.6 339.4 0.0176 0 555 N N2.1 289.3 769.7 0.0126 0.0024 1059 N N6.0 424.8 1285.2 0.0108 0.0045 1710 N N3.1 134.4 312.6 0.009 0.009 447 N N1.0 290.1 576.9 0.0105 0.0015 867 N N1.0 290.2 546.8 0.0165 0.0015 837 N N0.0 217.3 598.7 0.0109 0 816 N N6.1 426.1 1181.9 0.0105 0.0049 1608 N N3.0 616 1682 0.0127 0.0017 2298 N N0.0 217.4 400.6 0.0154 0 618 N N5.1 217.7 592.3 0.0101 0.0082 810 N N5.1 738.8 1955.2 0.0146 0.0024 2694 N N0.0 361.7 772.3 0.0157 0 1134 N N0.0 680.1 1191.9 0.0222 0 1872 N N0.0 428.7 846.3 0.0181 0 1275 N N3.0 136.7 457.3 0 0.0066 594 N N7.2 362.2 717.8 0.0123 0.0084 1080 N N4.1 801.2 1856.8 0.0176 0.0019 2658 N N0.0 219.4 404.6 0.014 0 624 N N

4.1 293.1 852.9 0.0078 0.0045 1146 N N1.0 429.9 797.1 0.0187 0.001 1227 N N2.1 220.3 424.7 0.0137 0.004 645 N N1.0 363.6 716.4 0.0159 0.0012 1080 N N3.1 363.6 809.4 0.0106 0.0034 1173 N N4.0 137.8 465.2 0 0.0087 603 N N4.0 495.6 1241.4 0.0131 0.003 1737 N N0.0 294.6 614.4 0.0095 0 909 N N3.0 804.1 1769.9 0.0184 0.0015 2574 N N2.1 138.1 347.9 0.011 0.0051 486 N N2.1 559.5 1288.5 0.0141 0.0014 1848 N N1.0 138.4 290.6 0 0.0029 429 N N0.0 221.5 555.5 0.0113 0 777 N N6.4 432 1203 0.0123 0.0052 1635 N N4.1 365.2 846.8 0.0113 0.0043 1212 N N0.0 497 1438 0.012 0 1935 N N0.0 138.8 398.2 0 0 537 N N2.1 138.9 335.1 0.0097 0.0054 474 N N3.1 222.4 566.6 0.0052 0.0051 789 N N3.1 562.3 1198.7 0.0146 0.0022 1761 N N0.0 433.8 751.2 0.0145 0 1185 N N5.1 434.1 1026.9 0.0117 0.0045 1461 N N8.2 1332.3 2912.7 0.0214 0.0026 4245 N N4.1 224.3 450.7 0.0065 0.0077 675 N Y6.2 564.4 1247.6 0.0157 0.0042 1812 N N1.0 224.6 471.4 0.0129 0.0019 696 N N4.1 436.2 811.8 0.0191 0.0041 1248 N N0.0 141.5 290.5 0.0106 0 432 N N3.1 436.7 823.3 0.0144 0.0031 1260 N N1.1 502 1178 0.0129 0.0008 1680 N N0.0 299.7 546.3 0.0102 0 846 N N0.0 299.8 546.2 0.0166 0 846 N N

12.2 1108.6 3199.4 0.0157 0.0036 4308 N N0.0 142.6 292.4 0.0106 0 435 N N0.0 226.5 589.5 0.0111 0 816 N N4.1 301.3 643.7 0.0095 0.0055 945 N N3.1 301.3 622.7 0.01 0.0042 924 N N5.1 301.4 736.6 0.0087 0.0062 1038 N N0.0 227.2 423.8 0.0158 0 651 N N0.0 143.6 279.4 0.0119 0 423 N N0.0 143.6 447.4 0 0 591 N N

12.4 569.5 1308.5 0.0133 0.0085 1878 N N2.0 303.1 875.9 0.0074 0.0022 1179 N N6.1 303.8 731.2 0.0135 0.0074 1035 N N0.0 229.5 550.5 0.0115 0 780 N N4.0 229.5 436.5 0.0072 0.0076 666 N N

19.2 1057.2 2866.8 0.0166 0.0062 3924 N N2.1 572.5 1029.5 0.0206 0.0016 1602 N N0.0 375.3 668.7 0.0136 0 1044 N N2.1 572.8 1107.2 0.0195 0.0015 1680 N N

10.1 636.6 1595.4 0.0148 0.0057 2232 N N5.0 699.4 2078.6 0.0133 0.0023 2778 N N3.2 376.9 799.1 0.0117 0.0033 1176 N N

3.1 231.3 401.7 0.0138 0.0062 633 N N0.0 306.6 701.4 0.0136 0 1008 N N1.0 377.3 966.7 0.0133 0.001 1344 N N4.1 575.4 1401.6 0.0134 0.0026 1977 N N1.0 147 294 0 0.003 441 N N5.1 307.3 853.7 0.0072 0.0057 1161 N N0.0 147.4 590.6 0 0 738 N N2.1 378.4 707.6 0.0159 0.0024 1086 N N9.5 308.2 681.8 0.0145 0.0116 990 N N3.1 512.8 1335.2 0.0128 0.0021 1848 N N1.0 447.1 899.9 0.0145 0.0009 1347 N N2.1 379.3 937.7 0.0098 0.002 1317 N N9.1 641 1516 0.0153 0.0053 2157 N N8.2 513.4 1145.6 0.0132 0.0063 1659 N N

18.4 826.4 1843.6 0.0168 0.0087 2670 N N0.0 309.3 575.7 0.0099 0 885 N N3.0 448.2 1159.8 0.0114 0.0024 1608 N N

17.4 704.5 1674.5 0.0172 0.0092 2379 N N3.0 148.8 412.2 0.0082 0.0069 561 N N

11.2 514.7 1417.3 0.0117 0.0074 1932 N N1.0 149.1 294.9 0.0103 0.0029 444 N N2.1 380.8 741.2 0.0165 0.0023 1122 N N6.1 888.3 2756.7 0.0136 0.0021 3645 N N6.0 149.5 396.5 0 0.0146 546 N N0.0 449.6 1173.4 0.0103 0 1623 N N8.0 450.2 1070.8 0.0117 0.0068 1521 N N0.0 382.2 646.8 0.0145 0 1029 N N0.0 235.7 412.3 0.0121 0 648 N N4.1 517.2 1036.8 0.0172 0.0033 1554 A N3.1 383.1 867.9 0.0138 0.0031 1251 N N3.1 383.1 933.9 0.0104 0.0029 1317 N N1.0 451.4 928.6 0.0131 0.0009 1380 N N4.1 708.4 2048.6 0.0136 0.0019 2757 N N0.0 150.9 278.1 0.0105 0 429 N N1.1 151.5 265.5 0.0115 0.003 417 N N0.0 520 1055 0.0162 0 1575 N N1.0 152.2 273.8 0 0.003 426 N N0.0 152.3 285.7 0 0 438 N2.1 386.4 984.6 0.0096 0.0019 1371 N N6.2 774.7 1712.3 0.0181 0.0031 2487 N N1.1 239.2 531.8 0.0118 0.0017 771 N N4.0 650.4 1443.6 0.0157 0.0024 2094 N N1.0 239.4 531.6 0.0122 0.0017 771 N Y9.1 586.9 1684.1 0.0128 0.005 2271 N N3.1 239.5 552.5 0.0113 0.0049 792 N N4.2 775.5 1738.5 0.0185 0.002 2514 N N1.0 239.7 804.3 0.0044 0.0012 1044 N N3.1 522.4 1058.6 0.0138 0.0025 1581 N N0.0 153.8 263.2 0.0104 0 417 N N7.2 522.9 1406.1 0.0112 0.0047 1929 N N2.0 456.6 1076.4 0.0151 0.0017 1533 N N9.1 714.9 1463.1 0.0204 0.0052 2178 N N5.1 523.3 1114.7 0.0137 0.0039 1638 N N

2.1 456.8 830.2 0.0187 0.002 1287 N N0.0 154.7 304.3 0.0096 0 459 N N

10.4 960.6 2483.4 0.0153 0.0039 3444 N N3.1 241.5 652.5 0.0048 0.0044 894 N N0.0 155.3 315.7 0.0104 0 471 N N2.1 458.7 1092.3 0.0139 0.0017 1551 N N0.0 654.5 1382.5 0.0183 0 2037 N N4.0 318.5 857.5 0.012 0.0043 1176 N N0.0 242 433 0.0124 0 675 N N3.1 318.8 683.2 0.0084 0.0039 1002 N N1.0 155.9 303.1 0 0.0027 459 N N2.0 319.6 634.4 0.0094 0.0027 954 N N4.2 391.6 757.4 0.0155 0.0045 1149 N N0.0 527.3 1011.7 0.014 0 1539 N N

14.4 592.7 1516.3 0.0136 0.0085 2109 N N0.0 157.1 373.9 0.0083 0 531 N N2.1 528.8 1118.2 0.016 0.0016 1647 N N3.2 157.4 265.6 0 0.0093 423 N N0.0 321.3 632.7 0.0144 0 954 N N5.0 322.5 1084.5 0.0065 0.0046 1407 N N3.2 463.7 958.3 0.0159 0.0027 1422 N N1.1 322.8 703.2 0.0087 0.0013 1026 N N1.0 246 528 0.0059 0.0017 774 N N2.1 246.4 527.6 0.0114 0.0034 774 N N4.1 464.9 765.1 0.02 0.0041 1230 N N3.0 159.7 503.3 0 0.0058 663 N N3.1 532.9 1276.1 0.0117 0.0022 1809 N N0.0 247.4 388.6 0.0071 0 636 N N0.0 397.3 1273.7 0.0075 0 1671 N N5.1 397.5 991.5 0.0106 0.0045 1389 N N1.0 160.7 262.3 0.0109 0.003 423 N N

14.4 913.7 2353.3 0.0155 0.0055 3267 N N14.4 913.7 2353.3 0.0155 0.0055 3267 N N

5.1 248.7 660.3 0.0102 0.0071 909 N N8.4 974.7 2106.3 0.019 0.0034 3081 N Y4.2 601 1319 0.0164 0.0027 1920 N N1.1 326.7 624.3 0.009 0.0014 951 N N4.1 399.6 686.4 0.0174 0.0047 1086 N N1.1 162 306 0.0094 0.0028 468 N0.0 162.1 326.9 0.0092 0 489 N N0.0 469.7 871.3 0.0133 0 1341 N Y1.0 400.4 1237.6 0.008 0.0008 1638 N N

13.3 162.6 539.4 0 0.0242 702 N0.0 162.7 329.3 0.0086 0 492 N N3.1 471.1 1100.9 0.0111 0.0025 1572 N N

11.1 918.4 2405.6 0.0144 0.0043 3324 N N0.0 401.8 696.2 0.0172 0 1098 N N1.0 251.6 441.4 0.0129 0.0019 693 N N3.0 329.3 1086.7 0.0067 0.0027 1416 N N5.2 539.3 1200.7 0.0154 0.0037 1740 N N1.0 163.8 316.2 0.0089 0.0027 480 N N5.1 164 514 0 0.0097 678 N Y3.1 472.5 1054.5 0.0111 0.0026 1527 N N

0.0 252.7 635.3 0.0091 0 888 N N0.0 330.9 602.1 0.009 0 933 N N1.0 331.2 592.8 0.0115 0.0015 924 N N3.1 607.5 1618.5 0.0117 0.0018 2226 N N0.0 253.6 448.4 0.0142 0 702 N N1.0 165.2 287.8 0.011 0.0028 453 N N8.0 404.8 1116.2 0.0093 0.0067 1521 N N6.1 673.8 1660.2 0.0143 0.0033 2334 N N2.0 406.2 931.8 0.0134 0.0019 1338 N N3.0 166.4 316.6 0 0.008 483 N N1.0 333.5 650.5 0.0133 0.0013 984 N N0.0 166.7 376.3 0.0082 0 543 N N1.0 167.2 342.8 0 0.0025 510 N N0.0 167.4 507.6 0 0 675 N N0.9 478 1172 0.0106 0.0008 1650 N Y3.1 256.7 484.3 0.0057 0.0053 741 N N2.0 478.5 1162.5 0.0113 0.0016 1641 N N

10.2 612.9 1520.1 0.0149 0.0061 2133 N N0.0 335.8 591.2 0.01 0 927 N N1.0 479.7 936.3 0.0139 0.0009 1416 N N0.0 409.6 697.4 0.0128 0 1107 N N0.0 336.3 773.7 0.0111 0 1110 N Y

11.3 1173.4 2906.6 0.017 0.0035 4080 N N0.0 258.7 473.3 0.012 0 732 N N3.1 169.5 295.5 0.0099 0.0083 465 N N2.1 337.5 859.5 0.0113 0.0022 1197 N N3.1 337.6 829.4 0.0079 0.0033 1167 N N1.0 482 874 0.0138 0.0009 1356 N N2.1 170.2 336.8 0 0.0051 507 N N

10.3 681.7 1604.3 0.0132 0.0057 2286 N N3.2 746.1 1863.9 0.0162 0.0015 2610 N N2.1 412.1 748.9 0.0117 0.0022 1161 N N4.2 995.8 2202.2 0.019 0.0016 3198 N N

16.2 1236.5 2846.5 0.0171 0.0051 4083 N N2.0 171.1 587.9 0 0.0034 759 N N1.1 483.4 1190.6 0.0135 0.0008 1674 N N3.0 483.6 1304.4 0.0102 0.0022 1788 N N2.1 261 522 0.0057 0.0033 783 N N3.1 171.8 416.2 0.0076 0.0066 588 N N4.2 554.3 1110.7 0.0161 0.0031 1665 N N1.0 341.9 1017.1 0.0066 0.0009 1359 N N0.0 173.3 528.7 0 0 702 N N1.0 173.4 348.6 0 0.0026 522 N N1.0 263.4 471.6 0.0128 0.0017 735 N N2.0 416.7 945.3 0.0093 0.0019 1362 N N3.2 417 882 0.0136 0.003 1299 N N4.0 343.2 1135.8 0.0061 0.0035 1479 N N4.1 174.1 473.9 0.0067 0.0081 648 N N2.0 343.4 835.6 0.0082 0.0021 1179 N N2.0 174.4 869.6 0 0.0025 1044 N N5.1 174.5 434.5 0 0.0106 609 N0.0 418 767 0.0158 0 1185 N N2.1 689.5 1719.5 0.0133 0.0011 2409 N N

0.0 175.9 583.1 0 0 759 N N2.0 176.4 501.6 0 0.0038 678 N N3.1 346.5 814.5 0.0076 0.0034 1161 N N5.3 176.8 411.2 0.0071 0.0113 588 N N7.1 947.2 2220.8 0.016 0.0028 3168 N N0.0 177.9 326.1 0.0092 0 504 N N2.0 178.1 643.9 0.0055 0.0031 822 N N0.0 563.3 1194.7 0.0145 0 1758 N N3.1 424.3 925.7 0.0138 0.0028 1350 N N1.1 350 679 0.0123 0.0013 1029 N N2.1 496.3 1222.7 0.0105 0.0015 1719 N Y3.0 496.4 1426.6 0.0096 0.002 1923 N N1.0 351.2 1112.8 0.0062 0.0009 1464 N N2.1 566.4 984.6 0.0174 0.0017 1551 N N5.0 497.5 1293.5 0.0101 0.0036 1791 N N8.1 566.7 1212.3 0.0163 0.0057 1779 N N2.1 352.2 652.8 0.0086 0.0026 1005 N N5.1 427.2 973.8 0.0095 0.0046 1401 N1.1 568 1313 0.0142 0.0007 1881 N N0.0 272.7 549.3 0.0109 0 822 N N2.0 181.8 499.2 0.0066 0.0038 681 N N0.0 569 1504 0.0099 0 2073 N Y3.0 354.4 1073.6 0.0065 0.0027 1428 N N1.0 182.5 288.5 0 0.0027 471 N N2.0 274.2 757.8 0.0042 0.0025 1032 N N3.1 431.4 1089.6 0.0094 0.0025 1521 N N0.0 184.3 421.7 0.0074 0 606 N N0.0 185.1 348.9 0.0089 0 534 N N6.1 185.1 477.9 0 0.0121 663 N N5.0 277.2 718.8 0.0091 0.0065 996 N N1.0 433.4 1000.6 0.012 0.0009 1434 N Y7.1 774.4 2450.6 0.0119 0.0028 3225 N N0.0 185.9 441.1 0.0074 0 627 N N1.0 186 381 0 0.0023 567 N N0.0 435.4 986.6 0.0127 0 1422 N N0.0 577.8 1267.2 0.0116 0 1845 N N0.0 508.8 1099.2 0.0115 0 1608 N N0.0 362.4 786.6 0.0127 0 1149 N N2.1 363.5 677.5 0.0127 0.0025 1041 N N4.0 581.5 1524.5 0.0112 0.0024 2106 N N2.0 363.9 878.1 0.0072 0.0021 1242 N1.0 364.1 763.9 0.007 0.0012 1128 N N7.1 190 620 0.0057 0.0111 810 N N0.0 283.6 568.4 0.0053 0 852 N N2.0 190.9 454.1 0 0.0039 645 N N1.0 191.2 342.8 0.0088 0.0024 534 N Y1.0 191.3 324.7 0.0092 0.0025 516 N N0.0 720.7 1769.3 0.0123 0 2490 N N4.1 443.5 924.5 0.0099 0.0038 1368 N N8.1 443.7 1065.3 0.0091 0.0068 1509 N N7.2 586.5 1234.5 0.0122 0.005 1821 N N3.9 655 1514 0.0129 0.0024 2169 N N0.0 286.5 523.5 0.0106 0 810 N N

4.1 517.6 1291.4 0.0097 0.0029 1809 N N0.0 193.8 343.2 0.0087 0 537 N N1.0 445.4 1165.6 0.0081 0.0008 1611 N N2.1 287.5 516.5 0.012 0.0032 804 N N0.0 194.7 381.3 0.0074 0 576 N N8.3 658.3 1501.7 0.0127 0.0048 2160 N N1.1 520.4 1330.6 0.0092 0.0007 1851 N N8.1 726.4 1835.6 0.0128 0.004 2562 N N0.0 371.4 624.6 0.0141 0 996 N N2.1 289.5 460.5 0.0102 0.0036 750 N N6.1 289.5 736.5 0.0043 0.0076 1026 N N1.0 447.9 1145.1 0.0084 0.0008 1593 N N5.8 659.7 1377.3 0.0151 0.0034 2037 N N5.8 659.7 1377.3 0.0151 0.0034 2037 N N

18.1 727 2150 0.0116 0.008 2877 N N1.0 289.9 616.1 0.0047 0.0014 906 N N0.0 196 809 0 0 1005 N Y1.0 448.5 913.5 0.0108 0.0009 1362 N N3.1 448.8 892.2 0.0131 0.0029 1341 N N2.0 522 1275 0.0129 0.0014 1797 N N3.1 449.2 939.8 0.0135 0.0028 1389 N N0.0 661.4 1291.6 0.0158 0 1953 N N4.1 291 609 0.0104 0.0057 900 N N

12.4 373.2 835.8 0.0117 0.0127 1209 N N0.0 523.3 1126.7 0.0132 0 1650 N N0.0 198.4 350.6 0.0082 0 549 N4.1 525.7 1100.3 0.0103 0.0032 1626 N N2.1 293.6 495.4 0.0112 0.0033 789 N N1.0 294.8 566.2 0.0115 0.0015 861 N N3.1 200.4 396.6 0 0.0064 597 N N5.1 735 1953 0.0111 0.0024 2688 N N7.9 735.1 1619.9 0.0111 0.0047 2355 N N2.0 295.3 841.7 0.0038 0.0023 1137 N N

12.3 378.1 698.9 0.0122 0.0146 1077 N N3.1 296 694 0.0091 0.0039 990 N N

10.1 803.6 2157.4 0.0128 0.0043 2961 N N4.2 456.7 971.3 0.0095 0.0036 1428 N N5.1 380 907 0.007 0.005 1287 N N1.1 458.5 816.5 0.0148 0.001 1275 N N4.9 532.4 1969.6 0.0075 0.0025 2502 N N1.0 203.8 447.2 0.0066 0.002 651 N N5.9 533 1603 0.0083 0.0036 2136 N N0.0 301.1 538.9 0.0117 0 840 N N7.3 940.6 2356.4 0.0156 0.0027 3297 N N8.2 535.9 1438.1 0.0088 0.0053 1974 N N5.1 536 1354 0.0117 0.0034 1890 N N1.0 536.2 1098.8 0.0108 0.0008 1635 N N4.2 536.6 1191.4 0.014 0.0029 1728 N N0.0 463.1 1066.9 0.0118 0 1530 N N1.0 206.7 396.3 0.0074 0.0021 603 N N6.2 206.9 459.1 0 0.0117 666 N N5.2 465.3 1154.7 0.0104 0.0041 1620 N N0.0 389.4 771.6 0.0077 0 1161 N N

1.0 467.8 1425.2 0.0068 0.0007 1893 N N2.1 307 587 0.0098 0.0029 894 N N1.0 307.2 607.8 0.0049 0.0014 915 N N3.0 469.2 1081.8 0.0112 0.0025 1551 N N1.0 308.3 909.7 0.0035 0.0011 1218 N N3.1 393.4 815.6 0.0112 0.0032 1209 N N2.1 393.8 992.2 0.0103 0.0018 1386 N Y9.2 618.8 1313.2 0.0112 0.0061 1932 N N4.0 547.1 1363.9 0.0095 0.0027 1911 N N3.1 689.5 1830.5 0.0108 0.0015 2520 N N2.0 214.1 619.9 0 0.0031 834 N N1.0 473.6 921.4 0.0124 0.0009 1395 N Y0.0 395.6 756.4 0.0113 0 1152 N Y0.0 214.6 490.4 0 0 705 N N3.2 1022.2 2109.8 0.0155 0.0012 3132 N N1.0 475.6 1150.4 0.008 0.0008 1626 N N0.0 313.2 547.8 0.0112 0 861 N N1.0 216.5 416.5 0.0073 0.002 633 N N0.0 218.7 429.3 0.0069 0 648 N N6.2 626.9 1383.1 0.0132 0.0039 2010 N N3.2 627.3 1370.7 0.0141 0.0019 1998 N N2.0 401.7 1023.3 0.0063 0.0018 1425 N N2.1 316.9 562.1 0.0098 0.003 879 N N5.0 1095.6 2645.4 0.0142 0.0017 3741 N N5.2 317.8 777.2 0.0037 0.0061 1095 N N2.0 403 854 0.0106 0.0021 1257 N N5.1 318.4 665.6 0.0094 0.0065 984 N N4.2 318.6 614.4 0.0099 0.0055 933 N N0.0 220.9 667.1 0 0 888 N N1.0 319.8 541.2 0.0105 0.0015 861 N N3.1 222.2 575.8 0 0.0048 798 N N2.1 484.8 988.2 0.0123 0.0017 1473 N N0.0 486.7 1079.3 0.0091 0 1566 N N0.0 487.1 1033.9 0.0122 0 1521 N N8.1 776.4 2082.6 0.0109 0.0036 2859 N Y2.0 225.2 713.8 0 0.0027 939 N N2.1 324.1 704.9 0.0089 0.0025 1029 N N5.1 226.4 640.6 0.0051 0.0075 867 N N0.0 226.4 508.6 0.0056 0 735 N N3.0 325.8 943.2 0.0072 0.003 1269 N N1.0 411.7 1190.3 0.0057 0.0008 1602 N N2.1 492.1 1304.9 0.0105 0.0014 1797 N N0.0 568.2 1012.8 0.0117 0 1581 N N0.0 328 674 0.0089 0 1002 N N0.0 229.4 457.6 0.0067 0 687 N N

12.2 784.4 1816.6 0.0122 0.006 2601 N N4.1 229.9 502.1 0.0063 0.007 732 N N6.1 495.2 1100.8 0.0081 0.0049 1596 N N2.1 230.4 501.6 0 0.0036 732 N N0.0 571.6 1063.4 0.0105 0 1635 N N4.0 1181 2866 0.0161 0.0013 4047 N N2.0 230.7 426.3 0.0071 0.0039 657 N N1.1 233.7 459.3 0 0.0018 693 N N

5.2 721.3 1615.7 0.0135 0.0028 2337 N N5.1 500.9 1137.1 0.0079 0.004 1638 N N1.0 235.4 403.6 0.0083 0.0019 639 N N0.0 235.6 364.4 0.007 0 600 N N1.0 235.7 460.3 0.0064 0.0019 696 N N4.0 336.1 695.9 0.0045 0.0049 1032 N N0.0 236.5 411.5 0.0073 0 648 N N0.0 654.9 1217.1 0.0157 0 1872 N N0.0 337.6 760.4 0.0079 0 1098 N N4.1 655.2 1561.8 0.01 0.0023 2217 N N3.1 338.2 1053.8 0.003 0.0029 1392 N N2.1 425.3 1026.7 0.0063 0.0018 1452 N N2.1 238.1 445.9 0 0.0037 684 N N2.0 338.6 675.4 0.0089 0.0025 1014 N N7.2 508 1022 0.0117 0.0059 1530 N N7.2 508 1022 0.0117 0.0059 1530 N N8.1 658.7 1615.3 0.0106 0.0045 2274 N N7.9 508.7 1471.3 0.0073 0.0051 1980 N N3.0 340.8 820.2 0.0079 0.0033 1161 N N0.0 428.1 780.9 0.0108 0 1209 N N5.0 240.3 806.7 0 0.006 1047 N N0.9 805.6 1579.4 0.0133 0.0005 2385 N N1.0 345.9 632.1 0.0095 0.0013 978 N N1.0 434.3 795.7 0.0114 0.001 1230 N N1.1 516.4 1508.6 0.0093 0.0006 2025 N N0.0 347.4 633.6 0.009 0 981 N N3.1 348.3 803.7 0.0079 0.0033 1152 N N1.0 247.6 529.4 0.006 0.0016 777 N0.0 247.9 571.1 0.0055 0 819 N N0.0 596.8 1080.2 0.0147 0 1677 N N6.2 746.2 1827.8 0.013 0.003 2574 N N0.0 523.1 1030.9 0.0118 0 1554 N N1.1 523.3 1171.7 0.0075 0.0008 1695 N N8.4 601.1 1405.9 0.0112 0.0052 2007 N N3.1 1221.4 2834.6 0.0145 0.001 4056 N N2.1 251.6 621.4 0 0.003 873 N N3.0 604.3 1432.7 0.0085 0.0019 2037 N N0.0 356.2 636.8 0.0085 0 993 N N3.0 445.1 1384.9 0.005 0.0021 1830 N N0.0 445.4 799.6 0.0103 0 1245 N N4.0 254.2 492.8 0 0.0068 747 N N3.1 754.7 2068.3 0.0096 0.0014 2823 N N2.1 255.9 488.1 0 0.0035 744 N N3.1 256.4 445.6 0.007 0.0054 702 N N3.0 683.9 2160.1 0.0079 0.0014 2844 N N7.1 1233 3207 0.0128 0.0021 4440 N N2.1 361 665 0.0089 0.0025 1026 N N0.0 260.2 528.8 0.0059 0 789 N N4.2 454.9 901.1 0.0105 0.0038 1356 N N0.0 261.8 509.2 0.0057 0 771 N N2.0 691.8 1786.2 0.009 0.001 2478 N N0.9 976.7 2338.3 0.0119 0.0004 3315 N N

20.1 1112.5 2958.5 0.0121 0.0064 4071 N N

2.1 263.9 426.1 0.007 0.0037 690 N N0.0 267 495 0.0056 0 762 N N0.0 372.4 587.6 0.0095 0 960 N N0.0 466.2 1120.8 0.0083 0 1587 N N5.1 551.2 1179.8 0.0103 0.0037 1731 N N1.1 468.5 1076.5 0.006 0.0008 1545 N N1.1 708.5 1355.5 0.0107 0.0006 2064 N N2.1 380.9 978.1 0.0032 0.0019 1359 N N5.1 382.2 958.8 0.007 0.0048 1341 N N4.1 279.3 623.7 0.0051 0.0057 903 N N4.0 281.2 792.8 0 0.0049 1074 N N3.0 480.7 1373.3 0.0047 0.0021 1854 N Y

10.3 1476.9 3563.1 0.0152 0.0026 5040 N N1.0 389.8 699.2 0.0086 0.0012 1089 N N5.3 568.7 1096.3 0.011 0.0039 1665 N N4.2 287 604 0.005 0.0058 891 N N0.0 878.9 1725.1 0.0121 0 2604 N N

11.3 488.9 1344.1 0.0074 0.0078 1833 N N0.0 489.2 1022.8 0.0089 0 1512 N N0.0 289.8 544.2 0.005 0 834 N N2.1 657.1 1229.9 0.012 0.0014 1887 N N3.2 294.2 500.8 0 0.0049 795 N N1.1 297.9 626.1 0.005 0.0014 924 N N5.2 965 2251 0.0116 0.002 3216 N Y3.0 299.2 813.8 0.004 0.0035 1113 N N0.0 586.6 1207.4 0.0103 0 1794 N N5.1 299.5 864.5 0.0039 0.0055 1164 N N1.0 300.6 539.4 0.0055 0.0015 840 N N4.9 410.7 1365.3 0.0023 0.0037 1776 N N6.2 753 1827 0.0098 0.0031 2580 N Y4.1 306.2 584.8 0.0051 0.0058 891 N N1.0 307.1 691.9 0.0044 0.0013 999 N N1.1 417.2 875.8 0.0033 0.001 1293 N N5.0 982.7 2377.3 0.0105 0.0019 3360 N N3.0 310.2 730.8 0.0048 0.0036 1041 N N0.0 310.7 589.3 0.0049 0 900 N N1.1 525.9 1055.1 0.0083 0.0008 1581 N N5.0 775.3 1438.7 0.0098 0.0029 2214 N N0.0 434.2 903.8 0.0069 0 1338 N N3.2 435 789 0.0075 0.0031 1224 N N7.1 442.1 1048.9 0.0062 0.006 1491 N N2.2 540.6 1079.4 0.008 0.0016 1620 N N3.0 333 780 0.0044 0.0034 1113 N N2.2 338.2 588.8 0.0051 0.0027 927 N N4.2 454.1 1069.9 0.0055 0.0035 1524 N N9.4 804.6 1598.4 0.0119 0.0048 2403 N N2.1 454.8 1096.2 0.0029 0.0017 1551 N N0.0 345.6 614.4 0.0051 0 960 N N3.2 1041.4 2114.6 0.013 0.0012 3156 N N5.1 974.2 2112.8 0.0115 0.0021 3087 N N7.2 822 2103 0.0076 0.0031 2925 N N8.3 1129.4 2311.6 0.0135 0.003 3441 N N2.0 745.6 1678.4 0.0094 0.0011 2424 N N

4.0 357.8 1049.2 0 0.0036 1407 N N3.1 359.8 678.2 0.0046 0.0037 1038 N N0.0 364.5 676.5 0.0045 0 1041 N N5.1 481.6 1162.4 0.0054 0.0039 1644 N N

16.4 589.5 1480.5 0.0044 0.01 2070 N N0.0 495.3 884.7 0.0064 0 1380 N N4.2 601.2 1222.8 0.0075 0.0028 1824 N N4.2 386.5 672.5 0.0045 0.0048 1059 N N0.0 395.7 744.3 0.0041 0 1140 N N

10.4 992.6 2304.4 0.0091 0.004 3297 N N6.0 746.9 2493.1 0.0042 0.0024 3240 N N8.1 1166.5 2535.5 0.0102 0.0028 3702 N N6.3 841.1 2032.9 0.0085 0.0026 2874 N N8.4 1171.9 2617.1 0.0108 0.0027 3789 N N0.0 446.7 873.3 0.0033 0 1320 N N1.1 452 1054 0.0027 0.0009 1506 N N4.1 693.7 1586.3 0.004 0.0023 2280 N N1.0 498.5 1046.5 0.0028 0.0008 1545 N N5.2 636 1434 0.0044 0.0031 2070 N N3.1 758.6 1473.4 0.006 0.0017 2232 N N3.2 545.3 990.7 0.0029 0.0025 1536 N Y0.0 599 1087 0.0026 0 1686 N N0.0 1063.9 2056.1 0.0057 0 3120 N N3.1 1380.8 2807.2 0.0064 0.0009 4188 N N

1E+04 1E+06 3E+06

4E-03

DescriptionGalactose permease, required for utilization of galactose; also able to transport glucoseGalactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4pUDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomersGalactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolismProtein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutationDNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3pTranscriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p bindingLysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids

GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167pPutative SAM4 homologPutative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome lossMitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteinsProtein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNAGlucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutationsCytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase

Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cuesPutative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological roleBasic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions

Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3pHistone deacetylase; regulates transcription and silencing; plays a role in regulating Ty1 transpositionEndo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectinsProtein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations

Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X

Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pHProtein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1pFerric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levelsSubunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3pProtein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genesProtein of unknown function proposed to be involved in the assembly of the spore wallMicrosomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides

) sites estimated by ML are shown.

ORFs with annotated single-copy orthologs in S. cerevisiae have systematic names, common names, and descriptions that correspond to the characterized S. cerevisiae ortholog.For significantly divergent genes, putative homologs and functions were assigned based on synteny (when available) and the best BLASTX score to the S. cerevisiae genome.

) are over-represented among highly divergent genes.

Lysyl-tRNA synthetase

Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternMembrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutantProton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT familyPutative CHA4 homologPutative HER2 homologLow affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions

High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose

Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complexPutative SDL1 homologNucleolar protein required for 60S ribosomal subunit biogenesisPutative CAR2 homologGeneral amino acid permease; localization to the plasma membrane is regulated by nitrogen sourceEnzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidineLow-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transpositionProtein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate

Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availabilityAlpha 7 subunit of the 20S proteasomeDNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint controlComponent of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clusteringMitochondrial ribosomal protein of the small subunitPutative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutantsMannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wallCatalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain

Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis IIMembrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity

Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethalZinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virusUbiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions

Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeasesEssential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexesPeroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32pCatalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidationComponent of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane

Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p

Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosomeProtein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds

Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeatsEssential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles

NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levelsMember of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolismOmega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasmNADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sourcesU3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNAGTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth

Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin

Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processomePutative lipoate-protein ligase A family member; null mutant is viable and displays reduced frequency of mitochondrial genome loss

Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression

Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis

Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleusPheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene familyRepressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNAUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasomeComponent of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hookEssential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family

Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes

Peroxisomal membrane E3 ubiquitin ligase required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disordersOuter kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assemblyNon-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1pPutative alpha-1,3-mannosyltransferase, not required for protein O-glycosylationProtein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole

Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingersComponent of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56

Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5pMitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphateMitochondrial ribosomal protein of the large subunitPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance is decreased upon intracellular iron depletionRNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere lengthComponent of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteinsAcyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen

Protein of unknown function, required for growth at high temperatureDeletion suppressor of mpt5 mutationER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activityProtein required for assembly of cytochrome c oxidase

Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2pPolyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases

RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis

Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficientlyD-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitroProtein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levelsTrans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycleEssential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice

6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase AMu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathwayProtein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4pProtein required for spore wall maturation; expressed during sporulation; may be a component of the spore wallTranscriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH responseSubunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesisMitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17pMitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stressProtein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathwayTranscriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expressionPlasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditionsO-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoproteinNADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMIDProtein of unknown function; null mutant is resistant to 2-deoxy-D-glucoseGlucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemiaCatalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signalingPutative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neckProtein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated

Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypesProtein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7

Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p fociNuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)

Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7pMitochondrial intermembrane space cysteine motif protein of 14 kDaMetallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C

Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharidesProtein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export

Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidificationTransportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosisArginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathwayProtein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleusPutative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assemblyPutative protein of with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss

Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritanceEssential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartmentsLactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannoseTranscriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleusProtein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvationMitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genomeSubstrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesisInositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviableSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinoneMulticopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transportRab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene

High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1pProtein of unknown function; null mutant shows K1 killer toxin resistanceNitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene

Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels

Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ERExosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translationNucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine productionAmphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stressProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternProtein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleusSecurin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nucleiNon-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p

Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11pA guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitinWD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene

Protein necessary for structural stability of L-A double-stranded RNA-containing particlesKinesin motor protein involved in mitotic spindle assembly and chromosome segregationSubunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeresGamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvationProtein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternVacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodiumPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiationSulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes

Mitochondrial ribosomal protein of the large subunit

Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation6-phosphogluconolactonase with similarity to Sol3pPhosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleusComponent of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translationInosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressedIntegral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intronSubunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonHistone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity

Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteinsProbable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteinsEssential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNASyntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins

Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs

Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cellsMeiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatidsProtein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transportProtein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination

Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationPhosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicingMitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membraneMitochondrial elongation factor involved in translational elongationMitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transportUracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleusDNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamilyTranscription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this geneProtein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungalsProbable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)

Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiencySubunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulationMitochondrial intermembrane space protein, forms a complex with Tim8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like mannerTranscriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducerGlycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-MMember of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturationMitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate

Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assemblyCytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1pProtein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functionsComponent of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p

RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2pNAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon sourceU1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicingDual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1pProtein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity

Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesisRibonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndromeCyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches

Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentationEpsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteinsComponent of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complexProtein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particlesProtein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperoneHexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucoseProtein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubulesPhosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheinePeptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histonesEssential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregationRNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation

Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesisAlanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases

Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p

Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKBProtein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4pAlpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stressTarget membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin

3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activityAcetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growthRNA polymerase I subunit A34.5Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32pHydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex

Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73pProtein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternProtein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transportEssential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein familyTranscription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphataseVacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathwayPutative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthaseBifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52pEssential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassemblySingle-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 proteinProtein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domainProtein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesiclesProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4pMitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respirationProtein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5pActivator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulationCholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcriptionMitochondrial ribosomal component of the small subunit

Mitochondrial protein of unknown functionSubunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chainProtein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo

Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyrv-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane

Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoAMember of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteinsBAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesisProtein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitroPutative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA exportMitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilizationComponent of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepressionMultistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2pPeripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAPCadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport functionPost-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane trafficMitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal proteinProbable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particlesCytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomesNADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallinSubunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonComponent of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein

Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particlesRegulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulatedHigh-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential geneSubunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding proteinMultistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stressesS-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratioMitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2pExosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genesCalcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombinationFumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondriaProtein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11pMitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxiaPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway

Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p

Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transpositionArginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate

Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recyclingSUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrateComponent of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivityComponent of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27pProtein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNAInhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogenRNA polymerase subunit, found in RNA polymerase complexes I, II, and IIIProtein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery

Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7pProtein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear divisionCytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stressHistone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75pOrotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compoundGTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosisCytoplasmic protein of unknown function; ubiquitinated protein with similarity to the human ring finger motif protein, RNF10; predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes hydrolysis of alkylated DNA

Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteinsNuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acidsProtein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteinsTranscription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromoneOne of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transitionProtein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathwaysPutative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome lossF-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strainsUBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48pGTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosisPermease of basic amino acids in the vacuolar membraneRNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit

Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growthPutative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulationEssential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control

S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeresConstituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasmCeramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesisEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosisJ-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16pProtein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviableVacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathwayNuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein bindingDihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexesDeoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated

Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm FUBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and cholinePossible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding siteEssential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family

Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathwaysMitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequencesRING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domainComponent of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartmentsGTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factorCytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cellsGuanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tipMember of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1pGlutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock

Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcriptionJmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombeProtein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4

Acetyltransferase required for Smc3p acetylation during the establishment of sister chromatid cohesion during DNA replication; required in response to double-strand breaks and during postreplicative double-strand break repairRNA polymerase III subunit C37Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesisSubunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediolProtein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11pPutative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome lossDelta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleusCentromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-APseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated proteinComponent of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses

Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stressDimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome

Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permeaseKey component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosisActin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167pInhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNADolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylationIntegral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrityEvolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPaseSubunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonPutative protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles

Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenineProtein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature

1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1pZinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1pMannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall

Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expressionIntegral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experimentsCytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complexRING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF

Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidaseProtein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinaseMitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotoleranceIntegral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complexProtein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesS-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratioHistone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domainZinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elementsPutative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvationDiacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism

Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structureMembrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1pSubunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116pMitochondrial ribosomal protein of the small subunitUbiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring fingerProtein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport

Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrievalPositive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolismEndoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesiclesBeta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases

Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase familyNuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleusRegulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulationMitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature

S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmCThiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents

Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L

Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ringSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway

Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transductionMember of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viabilityComponent of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrateAmino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance

Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal proteintRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNAPeroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential geneInositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproateMethionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan

Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance

Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shiftProtein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress

Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factorProbable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase familyEssential protein with similarity to phosducins, which are G-protein regulators; interacts with CCT (chaperonin containing TCP-1) complex; lethality of null mutation is complemented by expression of mouse phosducin-like protein MgcPhLPProtein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesiclesAromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolismPeripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animalsProtein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminaseProtein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase IPeripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)Mitochondrial ribosomal protein of the large subunit

Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to GolgiMitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressorRho GDP dissociation inhibitor involved in the localization and regulation of Cdc42pCytoplasmic protein with a role in regulation of Ty1 transpositionProtein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wallSubunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombinationProtein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1pProtein of unknown function, affects chromosome stability when overexpressedRNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNAProtein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins

Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesCoenzyme Q (ubiquinone) binding protein, functions in the delivery of Q₆ to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotesG1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth

Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assemblyComponent of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formationComponent of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrateSubunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover

Putative protein of unknown function; proposed to be involved in iron or copper homeostatis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structureCo-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ

Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin AMember of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46pInositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genesPutative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesSubunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex

Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper saltsCholine phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferasesSer/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10

Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleusDihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function

Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21pProtein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly

N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenineAlpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutantZinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteinsSoluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factorPhospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phaseEndosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factorPeptidyl-prolyl cis/trans-isomerase, activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complexPutative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential geneProtein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; functions as a heterotetramerProtein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractionsLipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interactPutative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization

Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis

Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutantSubunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenanceOligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates

Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis

Beta 6 subunit of the 20S proteasomeNucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96pTranscriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genesPutative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs

Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17

Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulationSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' endsPutative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome lossComponent of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAsPeroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21pProbable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploidsAspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesisSubunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2AMitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6pPalmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2pCatalytic subunit of TRAMP, a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; has 5'-dRP lyase activity; disputed role as a DNA polymerase

Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separationCytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate

Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1pProtein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr.

Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k proteinMajor apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosineProtein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domainO-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation

Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome lossPutative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patchesEssential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p

D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stressOne of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteinsMembrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism

Essential protein involved in rRNA processing and ribosome biogenesis

Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32pProtein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surfaceConstituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesisSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationProtein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4pSyntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formationComponent of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoAmRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38pPutative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesisTransverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrateSubunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomesPorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p

Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosisPhosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosolLipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groupsMajor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10Peroxisomal membrane protein (PMP) required required for the proper localization and stability of PMPs; interacts with Pex19p

Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranesCo-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activityPutative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein traffickingProtein of unknown function; mtc6 is synthetically sick with cdc13-1High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiaeAcyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membraneIntegral membrane protein of unknown function; member of the SUN-like family of proteins

Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeatsPutative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradientsChaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane

Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) familyConserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formationER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ERN-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA

Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolismCytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesSubunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha

RNA polymerase I subunit A14R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homologProtein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signalingSubunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA

Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bondsEssential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28pRNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigenPutative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p fociMitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier familyVacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporterNuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104pOne of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal mediumNucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediateCyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential geneVesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteinsMitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradationPutative zinc cluster protein; YBR033W is not an essential geneTail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate

High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon

E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domainProtein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genesProtein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome lossTransmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homologProtein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoterProtein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolusComponent of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditionsHistone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activityRiboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathwayNuclear pore protein involved in nuclear export of pre-tRNAEssential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunitsInner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycleProtein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradationSubunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunitPhospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress

Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteinsPhospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss

Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylatedSporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance

Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human NarfProtein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movementsProtein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stressExopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix

Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repairSubunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfideComponent of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phaseConserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviableEssential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18pGTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-GolgiPolyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamilyDNA replication licensing factor, required for pre-replication complex assemblyNon-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; null mutant excretes excess acetic acidProtein of unknown function, transcript accumulates in response to any combination of stress conditions

Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathwayNonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p

Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20pMitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteinsPlasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process

Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia

Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10

Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ERMitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains

Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potentialTranscription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses

Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1pRibosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing proteinHigh affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permeaseER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-LpNuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gammaIntegral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternProtein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II

TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIAProbable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiaeMinor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesisProtein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteinsPutative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription

3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosisRNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcriptionUbiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 proteinB-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phaseMitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels

Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19pActin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organizationKaryogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphaseCytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasmProtein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1pHydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway

Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenanceSubunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1Protein with a role in transcription; interacts with Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 shows genetic interactions with RPB4, 5, 7, and 9Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous cholineProtein that associates with ribosomes; putative metalloproteaseHomocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21pProtein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PASMeiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulationComponent of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesisPurine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathwayProtein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrateTrichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeatsDual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3pPhosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2pUbiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERADNitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responsesProtein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane

Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1pEssential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexesSubunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signalingLarge subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNANon-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis

Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activityThymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1pSubunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localizationSingle stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere cappingMitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria

Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21

Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptideOne of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growthMitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids

Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregationPheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling

Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursorGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolismSubunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassemblyStructural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membraneCarbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway

Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sourcesProtein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesComponent of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenanceProtein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane proteinHighly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spansOne of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domainProtein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surfaceMitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylatedPhosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteinsSubunit of the SF3a splicing factor complex, required for spliceosome assembly

Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11pProtein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutantsProtein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucineNudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate

Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transportMitochondrial and cytoplasmic valyl-tRNA synthetaseSphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheisProtein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membranePutative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p fociMitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p

GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesCytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiationProtein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumorsProtein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation

Protein involved in nucleocytoplasmic transport of mRNAPrimary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways

3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p

Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein foldingGolgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respirationMethionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAsProbable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this processPlasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily proteinSubunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair

RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complexMADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2pATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinasesPhosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteinsHydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phaseNucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28pSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' endsPutative protein of unknown function; deletion mutant has no readily detectable phenotype; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiationProtein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage

Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinasesPeripheral membrane protein of peroxisomes involved in peroxisomal inheritanceProtein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain

One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria

Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysisProtein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transportPhosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential

Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophoresDnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replicationBeta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesisSterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulumProtein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane

Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10pEssential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesisEpsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus

Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiationProtein of unknown function involved in the assembly of the prospore membrane during sporulationMolecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthasePutative transcription factor, has homolog in Kluyveromyces lactis5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistantGTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability

Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss; detected in mitochondria in high-throughput studiesProtein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteinsProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factorSubunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesiseIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascadeMitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activatorEssential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ERPutative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complexT subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasmPseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)Protein involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel

Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1pPutative protein of unknown functionSerine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGKActin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function

Copper-binding metallothionein, required for wild-type copper resistance

Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesisEssential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles

Mitochondrial tyrosyl-tRNA synthetaseSubunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunitsSubunit of the SF3a splicing factor complex, required for spliceosome assemblyEssential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunitsPart of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activityPutative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Protein involved in sister chromatid cohesion; mutation confers radiation sensitivity; related to the human Wapl protein that dissociates cohesin from interphase chromatinProtein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins

Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1pEndoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradationSplicing factor, component of the U4/U6-U5 snRNP complexPutative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome losHighly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPYProtein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2pMitochondrial ribosomal protein of the large subunit

Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNAMitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral geneSubunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin

Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function

Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leaderGlutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactionsPutative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transportersBeta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerasesThiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1pBasic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways

Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7pGlycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradationSubunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3pEssential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particlesRNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylationComponent of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNAPutative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesisCell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating

Golgi localized protein of unknown function; YDR367W is not an essential gene

Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p

Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidationArginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze toleranceThreonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesisComponent of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditionsCytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation terminationEssential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation

Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway

GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homologPeroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids

Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletionProtein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dyeMitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid systemEvolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance

Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolismNucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexesPseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteriaDNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteinsMitochondrial ribosomal protein of the large subunitComponent of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistanceLow-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translationElongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesisProtein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factorProtein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotateOne of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder

v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the GolgiGlutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesisHigh affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake

Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stressEssential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylationCoupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotypeProtein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damageProtein of unknown function; overexpression causes a cell cycle delay; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome lossPeroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini

Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexesPalmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeatsProtein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stressProtein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent mannerSki complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotypeProtein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditionsVacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulationProtein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATPBeta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptidesPeroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29pPutative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosisEpsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylatedProtein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; YIR003W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome lossDNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair

Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteinsInositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophyMitochondrial asparaginyl-tRNA synthetasePutative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agentsAcyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processesProtein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosinTranscriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genesEssential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p

Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 proteinProtein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2pMitochondrial ribosomal protein of the large subunit

Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1pProtein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditionsHistone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motifPhosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistanceNon-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polaritySUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombinationUridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathwaysHigh-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxideProtein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2pBisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathwayMeiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosisNucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1pPolypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocinProtein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylatedRegulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6

Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunitHistidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homologAlpha1,2-mannosyltransferase of the Golgi involved in protein mannosylationHighly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosolPutative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistanceGeneral transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]

Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport

Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferaseComponent of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere lengthProtein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling networkPutative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasisIron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p

Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p

Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndromePhosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START

Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)Mitochondrial ribosomal protein of the small subunitPutative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasmProtein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritanceProtein of unknown function proposed to be involved in protein secretion; interacts with Dsl1p and localizes to the ER and nuclear envelopeMitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs

Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb

Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10)

Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP

Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complexProtein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosisProtein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymesAllantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradationMitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxiaPlasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemiaChromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase

Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1pTFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIBMitochondrial ribosomal protein of the large subunitFructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p

Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathwayMitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damageEssential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defectPutative protein of unknown function; transcription dependent upon Azf1pv-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28

Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondriaMAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288CUBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p

Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein traffickingPeptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrateSphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growthPutative zinc finger protein; YPR013C is not an essential genetRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-AlaPutative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1pFarnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesisProtein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerizationSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosisProtein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of PKA subunit Bcy1p; implicated in mRNA nuclear export; involved in mitotic exit through regulation of Cdc14ptRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotesPutative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITPMitochondrial protein of unknown function; null mutant displays a slow growth defect in combination with a null mutation in the mitochondrial GTPase GEM1; null mutant displays reduced frequency of mitochondrial genome lossSubunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1pAdenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasomeSubunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenanceProtein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective)Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essentialMitochondrial ribosomal protein of the small subunitProtein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ proteinCatalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis

Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 familyAdenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycleHistone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulationEssential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family

Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongationPutative component of the protein phosphatase type 2A complexRNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenanceCarboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunitsMitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)Protein of unknown function; associates with meiosis-specific protein Spo1p

tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocinAlpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondriaVacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1pHSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifsComponent of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humansPhosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E

Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferasesProtein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 proteinDaughter cell-specific protein, may help establish daughter fateTFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter openingNegative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2pDelta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic formsOne of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutationMitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1pMitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesisDNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenanceSubunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1pCore Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G

Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p

Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrateProtein of unknown function, deletion causes hypersensitivity to the K1 killer toxin

Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3pProtein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal proteinDNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosisShort-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assemblyPresequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocaseNegative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progressionRNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleasesChaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme

Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p

Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formationSubunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpointGDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteinsAlpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTPMember of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasisProtein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1pEthanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathwayU2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm

Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulatedUDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulumProtein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER

Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1pStress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutantsProtein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrateEpsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus

Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrateEssential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunitsNon-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15pPutative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studiesProtein required for accurate chromosome segregation during meiosisSmall heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cellsG protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signalingEssential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shockSubunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase familyIntegral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals

Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylationSubunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunitMitochondrial ribosomal protein of the small subunitDolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylationCatalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substratesEssential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteinsTrimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphologyProtein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1pHistone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4pIntegral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2pSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzymeZinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulationMember of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growthProtein of unknown function that may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organizationPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrateGolgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutationProtein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteinsPutative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiationHeme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disordersProtein of unknown function; mtc2 is synthetically sick with cdc13-1

Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymesHexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activitiesSubunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domainComponent of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1pPutative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein of unknown function, required for normal microtubule organizationCell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12pNon-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein familyUroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway

Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activityHomeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4pSplicing factor, component of the U4/U6-U5 snRNP complexMitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndromeSecretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membraneHistone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily

Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transpositionOne of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunitsCheckpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteinsProtein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membraneD-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrateProtein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerizationSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationAlpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylatedPutative alanine transaminase (glutamic pyruvic transaminase)Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioningBasic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levelsProtein of unknown function required for iron-sulfur cluster assembly and sister chromatid cohesion; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencingConserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosisType I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly siteFarnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane

Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPasePutative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complexProtein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rateMinor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1pPredicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutantProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization

Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transportersComponent of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein traffickingNegative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1pMitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences

ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid controlNon-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assemblyProtein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondriaTelomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere cappingFusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B

FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditionsElongin C, forms heterodimer with Ela1p that participates in transcription elongation; required for ubiquitin-dependent degradation of the RNA Polymerase II subunit RPO21; expression dramatically upregulated during sporulationProtein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucosePutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential geneVacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosisMitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p

Component of the telomerase holoenzyme, involved in telomere replicationComponent, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexesProtein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cellsUbiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphataseCytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptakeProtein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein

Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3pcAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3pMitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutationProtein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2pVacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7pType II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromonePossible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction dataCell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization; required for propionic acid resistance

Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complextRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domainMitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJProtein required for respiratory growth and stability of the mitochondrial genomePutative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wallLsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNAAutoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genesNucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicasesProline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen sourcePutative RNA-binding protein required for the expression of early and middle sporulation genesCochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexesSubunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repairEssential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transportMitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration

Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2pComponent of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein

Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependentRNA polymerase III subunit C31; contains HMG-like C-terminal domainProtein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complexMitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexesMitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factorIntegral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targetingProtein of unknown function that associates with ribosomes; has a putative RNA binding domainTransaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphateHigh affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistanceInositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenancePutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocinSubunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritancePutative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167pProtein of unknown function, highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2pProtein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damageProtein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase

Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamilyProtein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere lengthClass II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII

tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamideProtein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar patternComponent of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complexEssential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition

Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growthNADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation productSubunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern

Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cellsProtein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transportDihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acidSerine protease and general molecular chaperone; involved in response to heat stress; may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteasesProtein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources

Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases

GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosomePutative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals

Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleusProtein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2pTranscriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1pChitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wallBeta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycleSubunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding

Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycansPutative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complexRNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p

MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288CPutative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutationProtein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutantsSingle-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replicationNucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosisFerrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathwaySubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionLow-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clusteringPutative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteinsHomolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivityProtein required for N6-threonylcarbamoyl adenosine (t6A) modification at position 37 in the anticodon loop of ANN-decoding tRNAs; null mutant is extremely slow-growing and respiratory growth deficient; member of conserved YrdC/Sua5 familyHigh affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by ironD-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotesSqualene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine

Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)

JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activityPutative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis

Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processingProtein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57pComponent of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repairCyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenancePeroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetaseDNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF familyProtein of unknown function; gene expression increases in cultures shifted to a lower temperatureOne of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genesCytosolic L-asparaginase, involved in asparagine catabolismNon-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phaseSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activityComponent of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EMMitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1pMitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6pTranscriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compoundsProtein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis

Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotypeEssential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1pPutative protein of unknown function; similar to Ups1p, Ydr185Cp and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growthPho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrateMitochondrial ribosomal protein of the large subunit

Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAsAdenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis

Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential geneComponent of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formationNucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesisSubunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chainSelf-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin

Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K proteinAlpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathwayProtein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport

Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repairProtein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1pSubunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcriptCo-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shockNADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources

Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditionsRING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1pMitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteinsHaploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells

Protein similar to Ashbya gossypii sporulation-specific chitinaseU2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family membersNADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormonesFerric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levelsSubunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complexNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ERType II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteinsGolgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late GolgiExo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p

Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance

Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA proteinGamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity

Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells

Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membraneActivator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis

Cytoplasmic protein of unknown function; essential gene in S288C background, while tsr4 null mutations in a CEN.PK2 background confer a reduced growth rateProtein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway

Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulationCheckpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 proteinBoron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54pMitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNAProtein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosisMember of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3Non-essential protein of unknown functionComponent of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartmentsProtein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domainCalpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palBPutative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screensHeat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregationsMitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenaseCholine/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositolSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregationProtein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19pSubunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligaseRNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complexPseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viabilityIntegral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12pNuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulationEssential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes

Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall

Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phaseProtein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrateGlycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulationHelicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28pMitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed

Protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5pGlycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesisProtein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis IIProtein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleusEndonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealingMajor exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymesMyo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4pProtein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosisPlasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species

Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membraneSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA bindingAcetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control

Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT geneCardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis

Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190pXanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanineSubunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesisHexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesisNitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prionProtein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surfaceMonomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress

Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1pCAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesisProtein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteinsComponent of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EMTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANIDinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteinsSubunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuolePutative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human orthologGlucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulationIntegral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrateRNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and IIIComponent of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenanceProtein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongationRegulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shockArgininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway

Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288CProtein of unknown function whose expression is induced by osmotic stressMalate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid mediumSubunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10pProtein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasmtRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repairTFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organizationApparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activityPutative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequencesBeta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domainMultifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesisTetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activityProtein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 proteinZn-ribbon protein that co-purifies with Dph1, Dph2, Eft2 and Elongator subunits Iki3p, Elp2p, and Elp3p as a complex required for synthesis of diphthamide, a modified histidine residue, and for modification of wobble nucleosides in tRNA

Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAsMeiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p

S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential geneConserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiencySerine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1Putative protein of unknown function, required for respiratory growth; YKL207W is not an essential gene

Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitroAlkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activityMitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1pTransmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathwayPumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNAProtein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair; deletion results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C

Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentationHigh affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transportProtein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombinationMitochondrial ribosomal protein of the large subunitMajor mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidyHtz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sortingComponent of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex

Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane

Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expressionSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53pSki complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decayHDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteinsLarge subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share functionPeroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acidsSubunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organismsProtein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutationsProtein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle

Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span

Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machineryComponent of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting poreCytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondriaPeroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced

Mitochondrial membrane protein of unknown function, contains no hydrophobic stretchesCytoplasmic protein of unknown function involved in vacuolar protein sorting.2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressedEssential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrateSubunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylatedProtein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteinsPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; over-expression confers increased resistance to hydrogen peroxide; human ortholog TMEM85 may function in apoptosisCore Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolismSET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability

RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditionsAcetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesisDiacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain

Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding proteinComponent of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditionsCleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complexPlasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ionsProtein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferasesCyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1pPutative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein of unknown function required for respiratory growth; detected in highly purified mitochondria in high-throughput studies; null mutation confers sensitivity to tunicamycin and DTT and decreased levels of phosphatidylethanolCytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stressComponent of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1pPutative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factorsMating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression

Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditionsAutophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conservedHistone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylationDethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levelsMu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting

Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II intronsNon-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Pap2p, genetic interactions with PAP2 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerasePre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeatsTwinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assemblyProtein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein familyUbiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clearWD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus

Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelopeProtein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential geneProtein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11pInosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitationTFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiationRedundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic regionTransmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cellMating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factorArsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3pComponent of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolismMeiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA proteinGlycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesiclesIsoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewingSubunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30

Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acidsSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregationDelta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondriaProtein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p proteinOne of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycleChorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis

Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement

Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complexPutative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci

Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domainPhosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adeninePutative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome lossEssential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24pcis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteinsProtein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK

Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20pEssential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolusPutative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinaseEssential protein of the mitochondrial inner membrane, component of the mitochondrial import systemN-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily

Mitochondrial ribosomal protein of the large subunitDiaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathwayPyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivativesProtein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMSProtein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF; essential for anaerobic growth

Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complexGlucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources

Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequenceTranslation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNADihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) corePutative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulationMitochondrial intermembrane space cysteine motif protein; mutation affects mitochondrial distribution and morphologyMitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p

Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteinsDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studiesPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; plays a role in restricting Ty1 transpositionProtein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1pMitochondrial ribosomal protein of the small subunitConstituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexesProtein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators

Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulationProtein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent mannerPermease of basic amino acids in the vacuolar membraneSilenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expressionRNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunitSignal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathwayHexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2pSubunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3pProtein that induces appearance of [PIN+] prion when overproducedProtein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7pMitochondrial intermembrane space protein, forms a complex with Mrs11p/Tim10p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like mannerGTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cellsEndoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein

GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) familyEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body

3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan

Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase IIPheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shiftProtein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylatedCovalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored

Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosisNicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleusTranscription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivoKaryopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradationHomoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathwayPeripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complexU1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeatsN-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteinsProtein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis

Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis

Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complexNuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding patternAlpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele

Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family

Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleusProtein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domainSerine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1pAllantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repressionFatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathwayS-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growthProtein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosisAsn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibitionEssential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complexLanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repairedMicrotubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl

Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1RNA polymerase subunit, common to RNA polymerase I and IIIProtein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p

Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1pCytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrateProtein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathwayDNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrateThird-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycleNAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance

5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p

Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification

Protein of unknown functionMembrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrateSubunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenanceMitochondrial ribosomal protein of the small subunitIntegral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles

Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11pProbable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genesMitochondrial protein involved in maintenance of the mitochondrial genomeSubunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1pBeta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathwayProtein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotypeHexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene

Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylatedSubunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth

Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essentialTFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrateLargest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA bindingSmall subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leaderSpore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze toleranceMitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesisProtein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol

Protein with a role in regulation of Ty1 transpositionUDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesisCytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagBComponent of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4pOuter kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubulesRNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III

Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions

Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches

Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferaseProtein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatasesTPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletionProtein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membraneUridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ERMyb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genesSporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formationPhosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complexProtein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome lossProtein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombinationUDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycinBeta 7 subunit of the 20S proteasomeCopper-sensing transcription factor involved in regulation of genes required for high affinity copper transport

Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNASubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcriptionNegative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunitType 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivationCytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signalCytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shockMicrotubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally

Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNAPutative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation

WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1

Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromonePhosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesisProtein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotesSubunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to itProtein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyinMitochondrial ribosomal protein of the small subunitProtein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchorsTranscriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenanceNucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesMembrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologsN alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2AATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAsCalmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurinPutative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome lossTranscription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexesTranslation elongation factor EF-1 gammaSubunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and hemeHomolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulationMitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol productionMultidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptakeProtein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiaminPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome lossMeiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repairSumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forksMitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophyNegative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB

Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respirationHsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulumv-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPaseShared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencingPeroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13pH subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasmComponent of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complexFatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrixHigh-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucoseZn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genesEssential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31pMember of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viabilityBeta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patchesHydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damageAAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolismGTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesisPantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA)Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regionsBeta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit ZAlpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase familyMitochondrial ribosomal protein of the large subunitProtein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal proteinMitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background

Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelityADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2pComponent of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1pAlpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenancePlasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zincComponent of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalHESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatinMethionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesisMitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidineAdenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequencePhosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2pEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosisProtein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar patternSubunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates

Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier familyMitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidaseUroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tardaC-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesisMajor ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene

Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutationsUbiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2Mitochondrial ribosomal protein of the small subunitEvolutionarily conserved copper-binding protein of the mitochondrial inner membrane, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motifAsparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathwayBeta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchorProtein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein

Tail-anchored, endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stressRibosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rateEndosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transportPutative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis

Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expressionProtein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domainSubunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulinHigh-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domainsCytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritanceProtein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal proteinCyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpressionGDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEPSubunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucomaComponent of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genesSubunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin

Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNAMinor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5Protein of unknown function; null mutant displays delays in meiotic DNA replication, nuclear divisions, and double-strand break repairSubunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viableSpermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid

Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesionLsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNAOne of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosisPrimary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondriaNuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing

Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnoverSubunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p

Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at the bud neck and at the bud tip

Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasomeProtein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair

Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate patternHigh-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters

Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formationTetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylatedFlavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavinSubunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo

Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis

Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase TSubunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growthSerine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signalProtein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif

Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathwayOutward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxinProtein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats

High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promotersMitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELIEndochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2pProtein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions

Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11

Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the budPutative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogenyProposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curingSerine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neckRNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud

RNA polymerase I subunit A43Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivityPlasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membraneProtein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2pRegulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling

Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosisCytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusionExosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrateComponent of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesiclesTATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viabilityComponent of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homologCytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complexNuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3pAlcohol dehydrogenase isoenzyme V; involved in ethanol productionBeta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sortingProtein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuoleMitochondrial protein, required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs; has similarity to mammalian thiosulfate sulfurtransferase (rhodanese)Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling moleculesSubunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61pMitochondrial ribosomal protein of the small subunitMannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteinsCytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1pProtein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspinsVesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteinsSubunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complexDNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymesAlpha 2 subunit of the 20S proteasomeTranscriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeatDihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylatedForkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; similar to PLM2Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidasesComponent of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EMProtein with putative serine active lipase domainSpecificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases

Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sortingProtein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetesPredicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase CProtein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteinsPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome lossMember of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complexMitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh SyndromeComponent of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growthCyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacityNucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrasesProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulationProtein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatusSubunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expressionPenta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasomeSubunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthaseSporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregationProtein that acts with Mms22p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; implicated in regulation of Ty1 transposition

C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleusAnthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesisPeroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)

Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturationProtein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes

Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2pPutative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesisPutative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutationSpecialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrixGlucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p

Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1pHistone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4pCis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sortingIntegral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutationProtein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondriaImidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4pProtein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant

Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p

Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusionMicrosomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemiaEssential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication originsNuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexesComponent of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathwayMitochondrial ribosomal protein of the small subunit

ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxesSelf-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogeninCis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesSporulation-specific protein with a leucine zipper motifDolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19pComponent of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistronBeta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality controlSubunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1pConstituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domainProtein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress responseBeta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylatedEssential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPasesSubunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasmOne of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasomeVacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteinsComponent of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p

Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase AEndoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein

Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)

Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase

Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocinMitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA

Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growthProtein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organizationPutative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylationSubunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombinationSubunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencingPutative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditionsType 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivationSubunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNAPeroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleateProtein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteinsPhenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophanSubunit of the RPD3L complex; involved in histone deacetylationPlasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential proteinMitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial functionIntegral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondriaProtein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein

Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gelsRegulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polaritySignal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with Srp102pDihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p

Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acidVacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistanceProtein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion

Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucoseMitochondrial ribosomal protein of the small subunitScaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activityPutative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiaesn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viabilityExosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3)Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential geneNicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesisS-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1pTranscriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)

Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosolSubunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assemblyInducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotrioseComponent of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck proteinPutative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolismPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene

Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growthNa+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4pProtein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesZinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82pSteryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranesReceptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCRProtein required for mitochondrial iron-sulfur cluster biosynthesisMitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressedB-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2APresumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azolesSubunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-PSubunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturationDelta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesisType 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organizationProtein with an apparent role in acetylation of N-terminal methionine residuesSubunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5pEssential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear poresSubunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasmTFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors

Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteinsProtein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal proteinVacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvationProtein involved in mRNA export, component of the transcription export (TREX) complexCullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p

Mitochondrial ribosomal protein of the small subunitNucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutationADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3pDelta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylatedProtein containing GATA family zinc finger motifsRibosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk componentKinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrateEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachmentsSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptationMinus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substratePutative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions

Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wallMember of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxiaSerine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor

Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm EProtein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndromeDihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoAEvolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulumKetopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoateSubunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranesDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2pVacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion

Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phaseMember of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimersCytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homologRibosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasmGamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargoRibosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistanceDNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domainNon-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathwayProtein involved in silencing; may recruit or stabilize Sir proteins; role in Rad51-dependent homologous recombination repair and intra S-phase DNA damage checkpoint; member of the RENi (Rad60-Esc2-Nip45) family of SUMO-like domain proteinsProtein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viabilityProtein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localizationComponent of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganineMannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatusProtein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaksEssential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotypeSerine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotoleranceB-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradationSubunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear traffickingProtein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteinsSubunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNAProtein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA

Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulationATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasmCatalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1pRan GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexesCatabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine

Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIPTranscription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexesAcyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygenOne of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase BCentral plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membraneVacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone responseSubunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection

Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter regionPlasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22pSubunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cellsConstituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocationPutative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiencyN-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transductionPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; has a role in protein synthesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential geneMitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop proteinUnique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assemblyConserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organismsAlpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubulesSubunit of the INO80 chromatin remodeling complex

cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p

Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophaseCopper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase

Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1pMultistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1pSeipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophyProtein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins

Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNASorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20pUbiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activityProtein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrateMevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonateComponent of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosomeDNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viabilityNucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin

Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expressionPhosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipidsATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunitSubunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesionDNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1pBifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2pProtein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradationPutative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesUbiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2BEndoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surfacePalmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domainPhenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathwayATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAsRibonucleoprotein that contains two RNA recognition motifs (RRM)Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcriptionPlasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugsPutative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest

Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase

Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethalCytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hostsProtein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1pEssential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motifSerine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expressionProtein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stressLong-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids

Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteinsGDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structureMitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translationCell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growthCyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5pMyristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranesPhosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutationMitochondrial ribosomal protein of the large subunitEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosisEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosisMitochondrial ribosomal protein of the large subunitProbable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies

Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathwayMitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factorPutative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases

Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase

Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis

Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formationEssential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domainMitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane

Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencingSubunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids

Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNANucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motifMitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteinsUreidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repressionProtein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; detected in highly purified mitochondria; null mutant suppresses cdc13-1; similar to a G-protein coupled receptor from S. pombeProtein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleusProtein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditionsProtein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositolUridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motifGTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesiclesConserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle

UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagyGTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p

Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surfaceChaperone that associates with and participates in the assembly of the 19S proteasomal regulatory particle; involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p; related to human 19S subunit S5bPutative ribokinaseMitochondrial ribosomal protein of the large subunitLyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome

Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membraneNon-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a proteinCalnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeastPhospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesisUbiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitroMember of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomesNegative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradationUBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48pProtein required for growth of cells lacking the mitochondrial genomeMitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA genePutative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesisUbiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respirationSulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionineRegulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcriptionSubunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2betaAcetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranesSubunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxinMannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wallZinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrateComponent of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clusteringRNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domainATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esp2pGPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1pSilenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expressionATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; homologous to mRNA export factor from S. pombe and similar protein from C. albicansSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunitsConstituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesisFunctionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p

Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humansEssential protein of unknown function; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; tagged protein localizes to nucleus and nucleolus; similar to WDR55, a human WD repeat proteinTriacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrateSubunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenanceSubunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylatedSubunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylatedProtein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humansIntegral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homologAsn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicingConserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replicationPeripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27pMitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs at position 32

Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation

Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar patternProtein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growthMitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate

Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleusType I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein responseS-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAsProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1pConstituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domainNuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2pProtein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential geneHistone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase familySplicing factor, component of the U4/U6-U5 snRNP complexProtein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulationGeneral repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genesProtein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1pProtein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamilyCytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling networkNAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonucleaseHydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damageFerredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxinPutative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutantRNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome

Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagDTranscription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrateConstituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenanceCell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factorProtein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experimentsUbiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to polyubiquitin elongation activity of Hul5p

Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal proteinProtein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA proteinPutative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2

Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formationPutative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1pZinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family

One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stackstRNA methyltransferase, methylates the N-1 position of guanosine in tRNAsProtein with a role in intracellular transport; has sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand familyLanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 familyProtein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2pIntegral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases

Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a

Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assemblySubunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p

Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stabilitySerine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutantProtein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombinationProtein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene

Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest

Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complexProtein of unknown function, expression is regulated by phosphate levels

Mitochondrial translational activator of the COB mRNA; phosphorylatedU1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeatsProtein of unknown function proposed to be involved in N-acylethanolamine metabolism; related to human NAPE-selective phospholipase D enzyme; native protein is detected in highly purified mitochondria in high-throughput studiesArf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7pNucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA

Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3pVacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiencyCytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growthGTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2

Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activatorEssential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 familyProbable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexesPeripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20pProtein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1pCell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrateTranslation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4GCyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylationHsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acidNucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenanceRNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7pCytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTTSilencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1pLow-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growthProtein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal proteinSubunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levelsProtein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrateActivator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assaySeparase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1pN-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5pPlasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potentialt-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homologRibonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1); related to human AGS4 that causes Aicardi-Goutieres syndrome

Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptakeTranscriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteinsMitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during buddingPutative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasmProtein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome lossHistone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethalityProtein of unknown function, contains a SET domaintRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential genePutative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth

Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organizationRibosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasmAlpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transportRNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome lossComponent of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitinNon-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1pBasic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responsesCitrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors

Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme familyProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaqueProtein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpEProtein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicinCytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation

Subunit of DNA primase, which is required for DNA synthesis and double-strand break repairMitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier familyGTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth

Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions

Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters

3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1pVacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusionRNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transpositionPheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12pPutative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p fociSubunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membraneMitochondrial ribosomal protein of the large subunitComponent of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migrationSignal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membraneComponent of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like proteinMitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structureAsparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathwayGamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transportEssential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER

Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growthSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionComponent of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion

Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondriaSubunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repairNuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombinationCalmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase IIEndoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6pCytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humansSH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosinsProtein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA

Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivityShuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1pHistone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatinProtein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutationsTriose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding regionFe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membraneInositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocinPhosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein

Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functionsTranslation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instabilityAllantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repressionMitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome

2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesisProtein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitinationMitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family

Protein of unknown function, involved in filamentous growthMitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal proteinRibonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunitsMitochondrial protein of unknown function; expression repressed by inositol and choline in an OPI1-dependent mannerFlavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteinsTranscription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availabilityProtein with a potential role in pre-rRNA processingHeat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrixNucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA exportPhosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17pCis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phaseCoiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2pTopoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1pCAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathwayNuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processingNucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell peripheryProtein expressed specifically in sporesMitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translationActivator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex

Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrateSsh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p

Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5

Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchangeCytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assemblyProtein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin

Protein of unknown function that associates with ribosomesCytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shockIntracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assemblyMitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactateEssential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3pProtein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiaeTranslation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; possible role in translation elongation; undergoes an essential hypusination modificationProtein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal proteinF-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1pNon-essential protein of unknown function; expression induced in response to heat stressTranscriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleusEndonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agentsProtein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercuryPutative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1pHigh-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86pVacuolar protein of unknown function; shares sequence similarity with the type V P-type ATPase Spf1p; null mutant is hypersensitive to manganese; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease 9AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutantsProtein phosphotyrosine phosphatase of unknown cellular role; activated by adenineNuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particlesPutative protein of unknown function; YER093C-A contains an intron; YER093C-A is not an essential genePhosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen sourceSubunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesisSubunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzymePyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosisEssential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3pGlutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotideGlyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall

Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat

Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p

Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transportersProtein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition

Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferasesPlasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p

E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt

Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase culturesSubunit of the INO80 chromatin remodeling complex

Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C proteinProtein of unknown function; undergoes sumoylation; MRP8 transcription in induced in response to cell wall stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysisOne of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathwayAnti-silencing protein that causes derepression of silent loci when overexpressedS-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA

Pheromone-regulated protein, predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiationMitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulumProtein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesPutative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway

Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosisPutative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci

Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesSubunit of DNA primase, which is required for DNA synthesis and double-strand break repairPeptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domainPhosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine

DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination

Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repairProtein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndromeCell wall and vacuolar protein, required for wild-type resistance to vanadate

Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesisTranscription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genesEssential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import

Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesisZeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteinsCatalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus

Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutationOne of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic

Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrixSubunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuolePutative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteinsProtein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferasesCytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathioneRibonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndromeProtein of unknown function containing pentatricopeptide repeat (PPR) motif; mutant is respiratory deficient and has defective plasma membrane electron transport; authentic non-tagged protein is detected in highly purified mitochondriaProtein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase IADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1pSubunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin

Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ERUbiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1pVacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen

Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexesMitochondrial ribosomal protein of the large subunitMember of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcriptsBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubulesLargest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatinProtein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr

Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter familyAutophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletionConserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23ptRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p fociZinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p

ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targetingPutative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulatedProtein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome lossTranscriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2pEssential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p

Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2ACatalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repairComponent of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelinCis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranesPeripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid raftsGamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesisSpermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cellsTargeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5pProcessing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stressRegulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ringProbable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growthProtein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p

Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damageHydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4pComponent of U4/U6.U5 snRNP involved in mRNA splicing via spliceosomeNuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis IIZinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes

Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylatedMicrotubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis IIEssential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for functionUBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate

Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradationSteryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism

Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particlesProtein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expressionSmall subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex

Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAsForkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switchingMitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conservedCytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPaseProtein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiationRNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4pSite-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1pExosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; possible role in chromatid segregationFunctional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomesMitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1pTranscriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint

D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasmPutative protein of unknown function; expression induced under carbon limitation and repressed under high glucoseMitochondrial protein of unknown function; null mutant has defects in cell morphology and in response to air drying; may be regulated by the transcription factor Ace2Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomesGuanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activityEssential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect

ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles

Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery

Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309pOne of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits

Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternMitochondrial ribosomal protein of the large subunitAlpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zetaEssential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defectsEssential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotesMitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiationSubunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3bGlutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stressProtein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolismProtein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal proteinMember of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p

Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elementsVacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTRLysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipidsProtein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10

Mitochondrial ribosomal protein of the large subunitProtein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ familySensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p

Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stabilityEssential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assayOne of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcriptionAdapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutivelyPhosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolaminePutative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1pSignal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway

ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homologProtein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12pProtein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55pPutative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distributionmRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexesEssential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosisTFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIAProtein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome lossSubunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; similar to RNA terminal phosphate cyclase-like proteins but RNA cyclase activity not detected

Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesisSubunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression

Protein of unknown function, similar to Rlp24p

GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)

Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human orthologCytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritanceNucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunitsSubunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28pMitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier familyPyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolismProtein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutantsSphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomesMeiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog

One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesisHsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1pAdaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functionsGlycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent mannerProtein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome lossHeat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvationDubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defectsPrimary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif

Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursorsTFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors

Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ERSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulationPolo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrateSubunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stressProtein of unknown function involved in the assembly of the prospore membrane during sporulationG protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeatsProtein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assemblyPutative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarityTranscription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family memberPutative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domainMethionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrateProtein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studiesActivating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesisNuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factorsGTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization

Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase BLong chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell peripheryProtein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrateCytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequenceProtein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ERMethionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2psnRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed

Mitochondrial ribosomal protein of the large subunitNuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationSubunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activityDNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damageOmega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization

Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucoseMitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processesProtein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal proteinOxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viabilityProtein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily

Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septinsCytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respirationRho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergenceNon-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)

Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutationGTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types

Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membraneProtein containing GATA family zinc finger motifsEssential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchorsPeroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18pTranscriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phaseEssential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COPSubunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membraneProtein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteinsActin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractinRegulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genesProtein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor AGTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenesTranscriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2pMitochondrial ribosomal protein of the large subunitPutative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determinationSubunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in mRNA splicing and adaptation to pheromone signalingEssential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosisProtein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formationMitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome

Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolusMitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondriaB-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation

Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p; localizes to the cytoplasmRNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein

V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V₀); overproduction confers resistance to Pichia farinosa killer toxinProtein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domainsIntegral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromoneSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA bindingProtein of unknown function, required for survival upon exposure to K1 killer toxinAlcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway

Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathwayTFIIE small subunit, involved in RNA polymerase II transcription initiationProtein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of buddingUbiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteinsProtein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesGamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole bodyProtein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugatesProtein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6pN-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatusConserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagyProtein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome lossCore component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membraneMitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized

Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation

Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase

Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradationInner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent mannerSmaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteinsSubunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p

Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamilyProtein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential geneComponent of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1pNexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17pProtein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesConserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurineEssential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein traffickingNon-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency

Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactionsEssential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1pC3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disordersSubunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall

Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during matingSubunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomesProtein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studiesLsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAsMajor CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesisSubunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription terminationOne of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval

N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocinComponent of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factorNuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transportSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machineryPutative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p

EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS

Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transportersMitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesisPlasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availabilityEssential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNAATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSFPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays elevated frequency of mitochondrial genome lossPutative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesPutative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell divisionProtein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrinProtein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic divisionPseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability

Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants

Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cationsProtein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex

ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertilityVacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusionProtein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilizationTriacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; phosphorylated and activated by Cdc28p; required with Tgl3p for timely bud formationBasic leucine zipper (bZIP) transcription factorSplicing factor that is found in the Cef1p subcomplex of the spliceosomeAldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathwayPutative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss

Putative serine/threonine protein kinase with unknown cellular roleDNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain

Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xyloseSubunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response, pseudohyphal/invasive growth, and vacuole inheritance; GBB motif (found in noncatalytic domains of PAKs) binds Ste4pComponent of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49pGTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domainBeta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expressionPutative protein of unknown function; not an essential geneRNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complexGTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab72'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loopSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' endsG1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellitesConserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactorRiboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membraneMitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylationSubunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonDaughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential geneMitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation

Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genesNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ERRING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein importProtein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panESubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionMember of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell peripheryCytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cyclePredicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosisProtein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport

Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1pUbiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress responseProtein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential geneGPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPIComponent of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functionsComponent of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stabilityProtein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeatPutative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; putative homolog of mammalian R3Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNAPutative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa proteinMitochondrial ribosomal protein of the small subunitEssential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phaseRho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7pPutative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteinsComponent of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteinsSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' endsProtein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistanceDihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrateEnolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactoneSubunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substratePhosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separationMitochondrial ribosomal protein of the large subunitNucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein

Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon hydrogen peroxide treatment; proposed to be involved in cell cycle progressionTelobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation

Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein

Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins

Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulonProtein of unknown function that associates with ribosomesPutative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential geneAlpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchorExosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNAProtein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2pNon-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necksAlcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewingNuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutantsProtein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartmentNucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvationUbiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate

Zinc cluster transcriptional activator involved in conferring resistance to ketoconazoleCytosolic protein required for sporulationdUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stabilityMitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modificationCopper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivationCytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitroPeripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25pmRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domainPutative nucleotide sugar transporter, has similarity to Vrg4pJmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase

Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding proteinProtein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assemblyVacuolar aminopeptidase Y, processed to mature form by Prb1p

Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reactionWD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fissionComponent of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicingEssential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particlesAcid trehalase required for utilization of extracellular trehalose

Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutationsTFIID subunit (65 kDa), involved in RNA polymerase II transcription initiationRibonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunitsMannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family

Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particlesNon-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasmKynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington diseaseComponent of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosisEssential component of the nuclear pore complex, which mediates nuclear import and exportSubunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoGuanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol

Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteinsSubunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysisSubunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication

PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sortingMitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translationComponent of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartmentsATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sitesProtein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesProtein required for optimal translation under nutrient stress; involved in TOR signaling pathway; binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structureCoronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assemblyCell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repairDNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repairN-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer

Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase familyMitochondrial ribosomal protein of the small subunitDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexesNADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductasesSubunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stabilityForkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defectsIntegral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartmentMitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FADProtein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathwayGTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenesNADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomesPolyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamilyMeiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosisMitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding regionPutative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressorsProtein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14pThiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)

Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complexC-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesisSerine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promotersRibose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis

Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc

Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin proteinPutative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase familyRNA polymerase subunit, common to RNA polymerases I and III

DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenanceTriacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes; required with Tgl4p for timely bud formationAlkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistanceProtein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein

Mitochondrial ribosomal protein of the large subunitS-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptorGamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met

Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteinsSporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pHProtein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elementsPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activityComponent of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice siteRNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' endXylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strainsCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin AProtein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleusPutative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum

Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier familyConserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptorLong chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acidsAlpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4pEssential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxinPutative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleusSingle stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1pProbable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein DullardSorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3pProtein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complexNucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43pProtein involved in mRNA turnover and ribosome assembly, localizes to the nucleolusProtein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteinsMinor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism

Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2pUbiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteinsC-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterolB-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasomeProtein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-betaHomo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipateProtein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defectsTetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesisMitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1pEsa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transpositionEndosomal protein that regulates cell polarity, controls polarized growth; similar to Ynr048wp and Lem3pConstitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiaminProtein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121

Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosisMiddle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2pMember of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiationZinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functionsInner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplicationATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis

Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequenceCore Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'

Alpha 6 subunit of the 20S proteasome

Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damageCovalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171CFunctional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationNucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1pRibonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)

cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2pProtein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1

Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; similar to E. coli S5 and rat S2 ribosomal proteinsProtein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioningArsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arseniteMitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assemblySerine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2pEssential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole bodyProtein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar patternEnzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidineProtein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of STARTPeroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycleMitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p

Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER

Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1pPalmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion

Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein

Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stressRibosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12BpMitochondrial ribosomal protein of the large subunit

Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFIIntegral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport

Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteinsCitrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial proteinPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesSmall subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motifPhosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylationSubunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPaseVacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonucleaseSignal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domainEndoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophsProtein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis

Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p

Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA

Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditionsGeneral transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sitesCdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10pOuter kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19pDeubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondriaCalcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stressGlyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall

N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethalNon-essential protein of unknown functionAlpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patchesNAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formateProtein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instabilityMyo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutivelySubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencingGeranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular trafficCovalently linked cell wall glycoprotein, present in the inner layer of the cell wallAllantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradationHigh affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movementSubunit of the chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; C-terminal region binds Sli15p, and the middle region, upon phosphorylation, localizes Cbf2p to the spindle at anaphaseIron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cationsHomocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20pPoly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assemblyPutative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2pCore component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membraneFarnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathwayProtein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR

Putative protein of unknown functionMultifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p

Putative hexose transporter, expressed at low levels and expression is repressed by glucosePlasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2pIsopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viabilitySubunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase PMultifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activitiesProline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-KSmall heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shockEssential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomesMember of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotypeAlpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteinsMitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombinationPutative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assemblyTrimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulatedNuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growthNucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organizationTyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasmOne of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cellsAutophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formationLow-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limitingDNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase betaPutative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesisEndoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitinationMeiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall proteinNucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNACytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity

Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shockSubunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonucleaseMitochondrial ribosomal protein of the small subunitSerine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factorEnolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucoseGTPase activating protein (GAP) for Gsp1p, involved in nuclear transportCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p

Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusionSubunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradationSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase PCystathionine beta-lyase, converts cystathionine into homocysteineS-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shakingConserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesisAlpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with diseasePlasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2pSubunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAsUracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathwayProtein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45pCarnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranesComponent of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complexER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; also interacts with Sbh1p; null mutant has an altered (mostly cisternal) ER morphology; member of the RTNLA (reticulon-like A) subfamilyProtein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence

Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C bindingMultivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domainThiol oxidase required for oxidative protein folding in the endoplasmic reticulumIntegral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during matingIntegral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucanAcidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNAPalmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathwayDDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expressionZinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acidsRNA 5'-triphosphatase, localizes to both the nucleus and cytoplasmNuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viabilitymRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasisConstituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits

C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugsNucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G₀ and the initiation of cell proliferationSubunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2AMitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4pPhosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPsSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase PTranscription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinaseTranscription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genesSubunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylatedCytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1pATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2pSubunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane

Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylatedGATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1pMeiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1pIntegral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viabilityCis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human BarkorProtein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studiesComponent of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodelingProtein with similarity to mammalian developmentally regulated GTP-binding proteinGlycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribedMitochondrial protein required for remodeling of ER caused by Hmg2p overexpression; null has decreased mitochondrial genome loss and decreased cardiolipin and phosphatidylethanolamine levels; like bacterial glutamyl-tRNA amidotransferasesEssential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein

Putative basic leucine zipper (bZIP) transcription factor

Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 familyBasic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmiumMitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leaderVacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activatesEH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1pSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification

Arginine methyltransferase; ribosomal protein L12 is a substrateCytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during matingElongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acidsNon-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradationLarge subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complexCell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1pFatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acidsRNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF

Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitroGolgi GDP-mannose transporter; regulates Golgi function and glycosylation in GolgiCytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesisComponent of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding patternPhosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth

Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrestTranslation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632pMitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2pBeta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelityIntegral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cellsGTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signalingProtein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1pPolyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains

Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunitsProtein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 proteinSubunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoProtein required for normal mitochondrial morphology and inheritance

Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipidsKynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1pMitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complexNon-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structureNADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde toleranceProbable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesisEssential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sourcesProtein of unknown functionMitochondrial inner membrane protein that binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicingComponent of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitinationCytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translationMitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylatedAlpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylationEndoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval

Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNAMitochondrial ribosomal protein of the large subunitMeiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation

Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 geneProtein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal poleProtein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p

Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1pVacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasmRho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assemblyMonopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindleMethyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasmPutative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occursProtein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrateCatalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus

GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transportMitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chainAlpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerasesEnoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4pPutative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2pNon-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly

Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunitRegulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathwayExosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3Component of the NuA4 histone acetyltransferase complex; required for initiation of pre-meiotic DNA replication, probably due to its requirement for significant expression of IME1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viabilityAMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools

Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulationt-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex

ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis

Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylationSubunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100pKaryopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistanceProtein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosiseIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutantTranslational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomesDelta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expressionProtein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenanceGuanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrateATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transportProtein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formationThreonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathwayRepressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptidesTranslational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATPATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth

Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA

Basic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions

Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X

Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p

Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes

Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides

Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidineLow-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transpositionProtein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate