Figure SM-1: Formula developed for: (a) Acetaminophen, and (b)

Erythromycin ethylsuccinate.

a b

Figure SM-2: Examples of EEM fluorescence spectra: (a) at pH 7.0 ± 0.1 of S-EPS from

GS-Eer, (b) with quenching effects obtained for 135 µmol/L of ACE, and (c) for 755

µmol/L of ERY. The white arrows indicate areas of interest, i.e. peaks A and B.

a

c

b

ERYpeak

A A

A

B B

Figure SM-3: Modeling of the fluorescence data from Figure S2

(B-EPS from GS-Eer) using the Stern-Volmer model. The F0/F

curve is represented at the Ex/Em couple: 222 nm / 300 nm

(aromatic protein region) (in blue), and 277 nm / 305 nm (soluble

microbial by-product-like region) (in red).

Acetaminophen (Paracetamol)

Erythromycin ethylsuccinate

CAS Number 103-90-2 1264-62-6

Formula C8H9NO2 C43H75NO16

Molecular mass (g/mol) 151.17 862.05

Density (g/cm³) 1.263 -

Melting point (°C) 169  229-224

Solubility in water (mg/mL) ()

12.78 VERY SLIGHTLY

IN WATER

pKa () 9.5 7.1

Log P 0.49 2.1

Table SM-1: Identification and characteristics of the drugs used in this study (Clarke, 1986; Tolls, 2001)