female reproductive system
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Female Reproductive System. The Highlights. Hormones of the Female Reproductive Cycle. Control the reproductive cycle Coordinate the ovarian and uterine cycles. Hormones of the Female Reproductive Cycle. Key hormones include: FSH Stimulates follicular development LH - PowerPoint PPT PresentationTRANSCRIPT
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Female Reproductive System
The Highlights
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Hormones of the Female Reproductive Cycle
• Control the reproductive cycle
• Coordinate the ovarian and uterine cycles
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Hormones of the Female Reproductive Cycle
• Key hormones include:– FSH
• Stimulates follicular development
– LH • Maintains structure and secretory function of corpus
luteum
– Estrogens • Have multiple functions
– Progesterones • Stimulate endometrial growth and secretion
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Female Reproductive Organs
• Ovary: female gonad• Uterine Tubes (fallopian tube, oviduct)
- three parts: infundibulum, ampulla, isthmus
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Figure 28.13
The Female Reproductive System in Midsagital View
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Figure 28.14a, b
The Ovaries and Their Relationships to the Uterine Tube and Uterus
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The Uterus• Muscular organ
– Mechanical protection– Nutritional support– Waste removal for the developing embryo and fetus
• Supported by the broad ligament and 3 pairs of suspensory ligaments
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Uterine Wall Consists of 3 Layers:
• Myometrium – outer muscular layer
• Endometrium – a thin, inner, glandular mucosa
• Perimetrium – an incomplete serosa continuous with the peritoneum
• The site of implantation of developing embryo• And 3 parts: fundus, body, and cervix
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Female Accessory Sex Organs: Uterus
• Uterine endometrium has two layers:
- basal layer
- functional layer: built up and shed each cycle
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Figure 28.18c
The Uterus
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Figure 28.19b
The Uterine Wall
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Figure 28.20
The Uterine CycleTo be discussed below
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Functions of the Ovary
• Production of a mature oocyte, capable of fertilization and embryonic development.
• Production of ovarian steroids (estradiol, progesterone).
• Production of gonadal peptides (inhibin, activin).
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Structural Organization of the Ovary
• The main functional unit of the ovary is the follicle.
• Follicles are composed of the oocyte, granulosa cells, and theca cells.
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Stages of Follicular Growth
• Follicles are present in a number of different stages of growth:- primordial follicles (resting)- primary, secondary, and antral follicles- preovulatory (Graafian) follicles
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The Corpus Luteum
• After the preovulatory follicle ovulates (releases its egg), it forms the corpus luteum.
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FEMALE REPRODUCTIVE SYSTEM The Ovarian Cycle
OVARY
3 to 5 million OOGONIA differentiate into PRIMARY OOCYTES during early development
OOCYTES becomes surrounded by squamous (follicular) cells to become PRIMORDIAL FOLLICLES
most PRIMORDIAL FOLLICLES undergo atresia leaving 400,000 at birth
oocytes at birth arrested at Meiosis I (prophase)oocytes at birth arrested at Meiosis I (prophase)
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FEMALE REPRODUCTIVE SYSTEM
OVARY
THREE STAGES OF OVARIAN FOLLICLES CAN BE IDENTIFIED FOLLOWING PUBERTY:(each follicle contains one oocyte)
(1) PRIMORDIAL FOLLICLES
- very prevalent; located in the periphery of the cortex
- a single layer of squamous follicular cells surround the oocyte
(2) GROWING FOLLICLES
- three recognizable stages:
(a) early primary follicle
(b) late primary follicle(c) secondary (antral) follicle
(3) MATURE (GRAAFIAN) FOLLICLES- follicle reaches maximum size
OO
GEN
ESIS
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FEMALE REPRODUCTIVE SYSTEM
OVARIAN FOLLICLES
(1) PRIMORDIAL FOLLICLES
(2) GROWING FOLLICLES
(a) early primary follicle
- follicular cells still unilaminar but now are cuboidal in appearance
- oocyte begins to enlarge
(b) late primary follicle
- multilaminar follicular layer; cells now termed granulosa cells
- zona pellucida appears; gel-like substance rich in GAGs
- surrounding stromal cells differentiate into theca interna and theca externa
(b) secondary (antral) follicle
- cavities appear between granulosa cells forming an antrum
- follicle continues to grow
- formation of cumulus oophorus and corona radiata
(3) MATURE (GRAAFIAN) FOLLICLES
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FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF OOGENSIS AND OVULATION
HYPOTHALAMUS release of GnRF which stimulates release of LH and FSH from the adenohypophysis (ANTERIOR PITUITARY)
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Neuroendocrine Regulation of Ovarian Functions
OVARY
E2, P
inhibin,
activin
Ovulation
Pituitary
GnRH
FSHLH
CNS
hypothalamus
Follicle
Development
Luteinization
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Effects of GnRH on Gonadotropins
• GnRH is released in a pulsatile manner, stimulating the synthesis and release of LH and FSH.
• GnRH acts through its receptor on the pituitary gonadotroph cells, stimulating production of phospholipase C.
• Recall that IP3 pathway causes gonadotropin release, while the DAG/PKC pathway causes gonadotropin synthesis.
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Actions of FSH on Granulosa Cells
FSH
Gs
AC
ATP
cAMP
PKA
CREB CRE
Steroidogenic
enzymes
LH Receptor
Inhibin Subunits
Plasminogen
activator
Gene Expression
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LH
androgens
estradiol
Theca cells
Granulosa cells
aromatase
FSH
Ovarian Estradiol Production
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Regulation of Progesterone Production
• Progesterone is produced from theca cells, mature granulosa cells, and from the corpus luteum.
• In this case, gonadotropins induce expression of
- steroidogenic acute regulatory protein
- P450 side chain cleavage
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• Estradiol also has important actions in a number of other tissues:- causes proliferation of uterine endometrium- increases contractility of uterine myometrium- stimulates development of mammary glands- stimulates follicle growth (granulosa cell proliferation)- effects on bone metabolism, hepatic lipoprotein production, genitourinary tract, mood, and cognition
• Effects are mediated through the intracellular estrogen receptors (alpha and beta), and possible membrane effects.
Actions of Estradiol
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Actions of Progesterone
• Progesterone exerts positive and negative feedback effects on gonadotropin synthesis and release.
• Progesterone also acts on many tissues:- stimulates secretory activity of the uterine endometrium- inhibits contractility of the uterine myometrium- stimulates mammary growth
• The actions of progesterone are mediated through an intracellular P receptor, which acts as a transcription factor.
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FEMALE REPRODUCTIVE SYSTEM The Menstrual Cycle
HORMONAL REGULATION OF OOGENSIS AND OVULATION
FOLLICULAR PHASE LUTEAL PHASEOVULATION
10-20 primordial follicles begin to develop in response to FSH and LH levels
FSH and LH stimulate theca and granulosa production of estrogen and progesterone
surge of LH induces ovulation
theca and granulosa cells transform into the corpus luteum and secrete large amounts of progesterone
if fertilization does not occur, corpus luteum degenerates ... if fertilization does occur, HCG released from the embryo maintains corpus luteum
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FEMALE REPRODUCTIVE SYSTEM The Menstrual Cycle
HORMONAL REGULATION OF OOGENSIS AND OVULATION
OVULATION:
sharp surge in LH with simulataneous increase in FSH
Meiosis I resumes; oocyte and surrounding cumulus break away and are extruded
oocyte passes into oviduct
ECTOPIC IMPLANTATIONS
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The Menstrual Cycle
• Women have ovulatory cycles of about 28 days in length.
• Day 1 of the cycle is defined as the first day of menstruation.
• There are two phases of the cycle, named after ovarian and uterine function during that phase:- first two weeks: follicular or proliferative stage- second two weeks: luteal or secretory stage
• The preovulatory gonadotropin surges occur in the middle of the cycle (around day 14).
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The Menstrual Cycle: The Ovary
• Follicular phase: small antral follicles develop, a dominant follicle is selected and grows to the preovulatory stage.
• Midcycle: the gonadotropin surges cause ovulation of the dominant follicle.
• Luteal phase: the corpus luteum forms and becomes functional, secreting large amounts of progesterone, followed by estradiol (results in negative feedback, not positive feedback, because P increases before E2).
• If pregnancy does not take place, the corpus luteum regresses, and P and E2 levels decrease.
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• Proliferative stage: increasing estradiol levels stimulate proliferation of the functional layer of the uterine endometrium.- Results in increased thickness of the endometrium.- Increased growth of uterine glands (secrete mucus) and uterine arteries.
• Secretory stage: progesterone acts on the endometrium.- uterine glands become coiled and secrete more mucus- uterine arteries become coiled (spiral arteries)
The Menstrual Cycle: The Uterus
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The Menstrual Cycle: The Uterus
• If pregnancy doesn’t occur, P and E2 levels decrease at the end of the secretory stage.
- vasospasm of arteries causes necrosis of tissue
- loss of functional layer with bleeding of uterine arteries (menstruation)
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FEMALE REPRODUCTIVE SYSTEM
UTERUS
ENDOMETRIUM
TWO LAYERS:
undergoes cyclic changes which prepare it for implantation of a fertilized ovum
(1) FUNCTIONAL LAYER (stratum functionalis)
(2) BASAL LAYER (stratum basale)
- BORDERS UTERINE LUMEN- SLOUGHED OFF AT MENSTRATION
- RETAINED AT MENSTRATION- SOURCE OF CELLS FOR REGENERATION OF
FUNCTIONAL LAYER
- CONTAINS UTERINE GLANDS
STRAIGHT AND SPIRAL ARTERIESSTRAIGHT AND SPIRAL ARTERIES
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FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF UTERINE CYCLE
(1) PROLIFERATIVE PHASE concurrent with follicular maturation and influenced by estrogens
(2) SECRETORY PHASE concurrent with luteal phase and influenced by progesterone
(3) MENSTRUAL PHASE commences as hormone production by corpus luteum declines
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Male Reproductive System
The Highlights
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The Male Reproductive System in Midsagital View
Figure 28.1
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MALE REPRODUCTIVE SYSTEM
TESTIS
- thick connective tissue capsule- connective tissue septa divide
testis into 250 lobules
TUNICA ALBUGINEA
(1) SEMINIFEROUS TUBULES(1) SEMINIFEROUS TUBULES
- each lobule contains 1-4 seminiferous tubules and interstitial connective tissue
- produce sperm
INTERSTITIAL TISSUE
- contains Leydig cells which produce testosterone
(2) RECTUS TUBULES(2) RECTUS TUBULES
(3) RETE TESTIS(3) RETE TESTIS
(4) EFFERENT DUCTULES(4) EFFERENT DUCTULES
(5) EPIDIDYMIS(5) EPIDIDYMIS
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MALE REPRODUCTIVE SYSTEM
SERTOLI CELLS
SERTOLI CELLS
SPERMATOGONIASPERMATOGONIA
1º SPERMATOCYTE1º SPERMATOCYTE
2º SPERMATOCYTE2º SPERMATOCYTE
SPERMATIDSSPERMATIDS
SPERMATOGENESISSPERMATOGONIASPERMATOGONIA 1º SPERMATOCYTE1º SPERMATOCYTE 2º SPERMATOCYTE2º SPERMATOCYTE SPERMATIDSSPERMATIDS
SERTOLI CELLS:SERTOLI CELLS:
- columnar with adjoining lateral processes- columnar with adjoining lateral processes
- Sertoli-Sertoli junctions divide seminiferous tubules into basal and adluminal compartments
- Sertoli-Sertoli junctions divide seminiferous tubules into basal and adluminal compartments
- extend from basal lamina to lumen- extend from basal lamina to lumen
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Basal Lamina
2n2n 2n2nSpermatogonia (stem cells)
2n2nmitosis
Daughter cell Type A spermatogonium remain at basal lamina as a precursor cell
Daughter cell Type B Spermatagonium
Moves to adluminal compartment
nn
nn 1° spermatocyte
nn
Meiosis I completed
2° spermatocyte
nn nn nn nn Early spermatids
n n n n Late spermatids
Meiosis II
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MALE REPRODUCTIVE SYSTEM
SPERMATOGENESISTHREE PHASES:
(1) Spermatogonial Phase (Mitosis)
(2) Spermatocyte Phase (Meiosis)
(3) Spermatid Phase (Spermiogenesis)
- acrosome formation; golgi granules fuse to form acrosome that contains hydrolytic enzymes which will enable the spermatozoa to move through the investing layers of the oocyte
- flagellum formation; centrioles and associate axoneme (arrangement of microtubules in cilia)
- changes in size and shape of nucleus; chromatin condenses and shedding of residual body (cytoplasm)
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MALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF MALE REPRODUCTIVE FUNCTION
HYPOTHALAMUS REGULATES ACTIVITY OF ANTERIOR PITUITARY (ADENOHYPOPHYSIS)
ADENOHYPOPHYSIS SYNTHESIZES HORMONES (LH and FSH) THAT MODULATE ACTIVITY OF SERTOLI AND LEYDIG CELLS
Luteinizing Hormone (LH): stimulates testosterone production by Leydig cells
Follicle Stimulating Hormone (FSH): stimulates production of sperm in conjunction with testosterone by regulating activity of Sertoli cells
SERTOLI CELLS STIMULATED BY FSH AND TESTOSTERONE RELEASE ANDROGEN BINDING PROTEIN WHICH BINDS TESTOSTERONE; THEREBY INCREASING TESTOSTERONE CONCENTRATION WITHIN THE SEMINIFEROUS TUBULES AND STIMULATING SPERMATOGENESIS
SERTOLI CELLS STIMULATED BY FSH AND TESTOSTERONE RELEASE ANDROGEN BINDING PROTEIN WHICH BINDS TESTOSTERONE; THEREBY INCREASING TESTOSTERONE CONCENTRATION WITHIN THE SEMINIFEROUS TUBULES AND STIMULATING SPERMATOGENESIS