felipe fregni office address: 79/96 13 st. spauld
TRANSCRIPT
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Harvard Medical School
Curriculum Vitae
Date Prepared: December, 2013
Name: Felipe Fregni
Office Address: 79/96 13th
St.
Spaulding Center for Neuromodulation
Charlestown, MA 02129
United States
330 Brookline Ave – KS158
Berenson-Allen for Noninvasive Brain Stimulation
Boston MA 02215
United States
Home Address: 4 Hackensack Terrace
Chestnut Hill, MA 02467 United States
Work Phone: (617) 952-6156
Work Email: [email protected]
Work FAX: (617) 952-6060
Place of Birth: Sao Paulo, Brazil
Education
1999 M.D. Medicine University of Sao Paulo
2004 PH.D. Medical Sciences/Psychiatry University of Sao Paulo
2006 M.M.SC. Scholars in Clinical Science
Program
Harvard Medical School
2007 M.P.H. Clinical Effectiveness Harvard School Of Public
Health
2012 M.Ed Master of Education Harvard Graduate School
of Education
Postdoctoral Training
01/00-12/01 Intern Internal Medicine University of Sao Paulo
(Clinics Hospital)
01/01-12/03 Resident Neurology University of Sao Paulo
(Clinics Hospital)
01/03-12/05 Post Doctoral Fellow Neuroscience Beth Israel Deaconess
Medical Center (East)
01/04-12/04 Visiting Fellow Neurophysiology Federal University of
Pernambuco
01/04-12/04 Visiting Fellow Clinical Neurophysiology University of Goettingen
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12/08-12/08 Visiting Professor Neurosciences University of Sydney
Faculty Academic Appointments
2002-2006 Research Associate
(non-voting
appointment)
Institute of Psychiatry University of Sao Paulo,
Sao Paulo, Brazil
2003-2005 Research Fellow Neurology Beth Israel Deaconess
Medical Center, Boston,
MA
2005-2007 Instructor Neurology Beth Israel Deaconess
Medical Center (East),
Boston, MA
2007-2008 Instructor Population and International
Health
Harvard School of Public
Health, Boston, MA
2007-2011 Assistant Professor Neurology Harvard Medical School,
Boston, MA
2008- Adjunct Professor in
the post-graduation
program (non-voting
appointment)
Psychology School University of Sao Paulo
(NEC - Nucleo de
Neurociencias), Sao Paulo,
Brazil
2011 Associate Professor Neurology Harvard Medical School,
Boston, MA
2011 Associate Professor Physical Medicine and
Rehabilitation
Harvard Medical School,
Boston, MA
Major Administrative Leadership Positions
Local
2006- Director, Clinical Trials Network Beth Israel Deaconess Medical Center
(East), Boston, MA
2008- Course planning, development and overall
leadership, Scholars in Clinical Science
Program
Harvard Medical School, Boston, MA
2008- Symposium organizer and speaker
I International Symposium in
Neuromodulation
Scala Institute and Mackenzie University,
Sao Paulo, Brazil
2008-2009 Director, Continuing Education, Scholars in
Clinical Science Program
Harvard Medical School, Boston, MA
2008 Course Director, Clinical Trials Course
Scholars in Clinical Science Program
Harvard Medical School, Boston, MA
2008- Course Director, teleconference symposium
on brain stimulation offered from Boston to
University Federal of Espirito Santo (UFES),
Brazil
Beth Israel Deaconess Medical Center,
Boston, MA
2009 International Planning, organization and
teaching for the I International Symposium
in Placebo
Scala Institute and Mackenzie University,
Sao Paulo, Brazil
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2009 Course Planning, Development and Overall
Leadership – I Symposium International on
Updates in Epilepsy – Sao Paulo, Brazil
Instituto Scala and University of Sao Paulo,
Sao Paulo, Brazil
2009-2010 Advisor, Catalyst Biostatistics BIDMC, Harvard Medical School, Boston,
MA
2009 Associate Researcher, Physical Medicine &
Rehabilitation
Massachusetts General Hospital, Boston,
MA
2009- Director, Spaulding Center for
Neuromodulation (laboratory with 10 large
rooms, 24 fellows/research assistants)
Spaulding Rehabilitation Hospital
2010 Conference Chair – II International
Symposium in Neuromodulation (large
international symposium with 400
participants and 30 speakers (15
international speakers))
University of Sao Paulo, Brazil; Mackenzie
University, Brazil and Scala Institute
2010 Course Director – Clinical, Assessment, and
Intervention Updates in Neurorehabilitation
Scala Institute & Spaulding Rehabilitation
Hospital, Boston, MA
Massachusetts Eye and Ear Infirmary
2010 Conference Chair – DRCLAS – David
Rockefeller Center for Latin American
Studies
Harvard University, Boston, MA
2010 Program Chair - “Integrating Technology
and Medicine for a Healthier Tomorrow.”
EMBC 2011 Conference
Institute of Electrical and Electronics
Engineers and the Engineering in Medicine
and Biology Society (IEEE-EMBS).
Boston, MA
2011 Conference Chair—III International
Symposium in Neuromodulation
(Symposium scheduled for June 2011)
University of Sao Paulo, Brazil; Mackenzie
University, Brazil and Scala Institute
2011 Course Director – Clinical, Assessment, and
Intervention Updates in Neurorehabilitation
Harvard Medical School, Boston, MA
2011 Program Co-director-Spaulding-Harvard
Spinal Cord Model Systems
Spaulding Rehabilitation Hospital-Harvard
Medical School-NIDRR Grant
2012 Research Director of Boston-Harvard Burn
Injury Model System
Spaulding Rehabilitation Hospital- Harvard
Medical School- NIDRR Grant
Committee Service
Local
2007- Admission Committee, Scholars in Clinical
Science Program
Harvard Medical School
Committee Member
2008- David Rockefeller Center for Latin
American Studies
Harvard Medical School
Advisory Board Member
2010 Harvard David Rockefeller Center for Latin
American Studies’ Summer Research
Harvard University
Committee Member
4
Travel Grant (SRTG) Committee
2010 Thesis Committee, Research School of
Biological Sciences, The Australian
National University
The Australian National University,
Australia
2010 Data Safety Monitoring Board –
International Multicenter Study on Deep
Transcranial Magnetic Stimulation
Brainsway DSMB
Committee Chair
2012 Data Safety Monitoring Board- for NIH
sponsored study entitled “Transcranial
Direct Current Stimulation to Treat
Aphasia: Phase II Trial” at the University
of South Carolina in Columbia and the
Medical University of South Carolina in
Charleston
NIH DSMB
Committee Chair
Professional Societies
2003-2006 Brazilian Neurological Association
2003-2006
Member
2004-2005 International Society of Movement
Disorders
2004-2005
Member
2009- American Medical Association (AMA)
2009-
Member
Grant Review Activities
2006 Interdisciplinary Studies on the Combat
Readiness and Health
2007
USAMRMC (CDMRP)
Grant Reviewer
2007 ALW Open Programme
2007
Netherlands Organization for Scientific
Research
Grant Reviewer
2007 MRC New Investigator Grant
2007
Medical Research Council (MRC)
Grant Reviewer
2007- Research Fellowship Program (PIBIC)
2007-
Mackenzie University
Reviewer
2008 Information & Communication Technology
(ICT), Biotechnology, and Sustainable
Energy and Energy Efficient Technologies
2008
Science Foundation Ireland
Grant Reviewer
2008 Research Fellowship
2008
Università degli Studi di Padova
External Reviewer
2009 Psychobiology Research The National Institute for Psychobiology in
Israel
5
2009 Grant Reviewer
2008-2009 Parkinson’s Disease Program, 2008-2009 Parkinson’s Disease Society
Grant Reviewer
2010-2011 Research Project Grant (RPG), 2010 James & Esther King Biomedical Research
Program, Florida Department of Health
Grant Reviewer
2010 Scientific Advisory Council, 2010 Reumafonds (Dutch Arthritis Association)
Netherlands
Grant Reviewer
2010 Research Project Grant, 2010 CIMIT (Center for Integration of Medicine
& Innovative Technology)
Grant Reviewer
2010 Fellowship Reviewer, 2010 National Committee in Sigma Delta
Epsilon, Graduate Women in Science
State University, NY
2010 Research Proposal Reviewer, 2010 Technology Foundation, STW – Dutch
Funding Agency for Academic Research
2010 Reviewer, Study Section (Neural Injury and
Epilepsy) – scheduled for Jan 2011
NIH, Brain Disorders and Clinical
Neuroscience
2010 Review Panel Member, 2010 Spinal Cord Injury Research Program
QR/CTR
2011 FAPESP – Pre-doctoral Grant Review
Section, 2011
Brazilian Sao Paulo State Fund Agency -
FAPESP
Editorial Activities
Acta Neurologica Scandinavica
Addiction
Alcoholism: Clinical and Experimental Research
American Journal of Physical Medicine & Rehabilitation
Annals of Neurology
Appetite
Archives of General Psychiatry
Archives of Physical Medicine and Rehabilitation
Arthritis & Rheumatism
Behavioral and Brain Functions
Biological Psychiatry
Biological Psychology
Bipolar Disorder
BMC Neuroscience
Brain
Brain Language
Brain Research
Brain Stimulation
Cerebral Cortex
Clinical Neurophysiology
Cognitive and Behavioral Neurology
Contemporary Clinical Trials
6
Disability and Rehabilitation
Epilepsy Research
Epilepsy Research Review
European Journal of Neuroscience
European Neuropsychopharmacology
European Journal of Pain
Experimental Brain Research
Experimental Neurology
Expert Review of Neurotherapeutics
Expert Reviews in Anticancer Therapy
Frontiers in Human Neuroscience
Human Brain Mapping (HBM)
Human Psychopharmacology: Clinical and Experimental
International Archives of Medicine
International Psychogeriatrics
Journal of Clinical Investigation (JCI)
Journal of Clinical Neurophysiology
Journal of Clinical Psychiatry
Journal of Dental Research
Journal of NeuroEngineering and Rehabilitation
Journal of Neurology Neurosurgery & Psychiatry (JNNP)
Journal of Neurophysiology
Journal of Neuroscience
Journal of Neurotrauma
Journal of Orofacial Pain
Journal of Pain
Journal of Pain and Symptom Management
Journal of Psychiatry and Neuroscience
Journal of Rehabilitation Medicine
Lancet Neurology
Movement Disorders
Neuroimage
Neurology
Neuromodulation
Neuropsychologia
Neuroscience and BioBehavioral Reviews
Neuroscience Letters
Neurosciences
Pain Medicine
Pain Practice
Parkinsonism & Related Disorders
PLOS ONE
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Psychiatry Research
Psychological Science
Psychology and Neuroscience
Psychoneuroendocrinology
Psychopharmacology
7
Respiration
Reviewer, Journal of Cognitive Neuroscience
Seizure
Stress
Stroke
The International Journal of Neuropsychopharmacology
The Journal of Clinical Investigation
The Journal of Nuclear Medicine
The Word Journal of Biological Psychiatry
Transactions on Biomedical Engineering
Other Editorial Roles
2004- Co-Editor Focus on Neurology
2008- Co-Editor Restorative Neurology and Neuroscience
(RNN)
2009- Co-Editor Neuromodulation, Technology at the Neural
Interface
2009- Co-Editor Journal of Neuroplasticity and
Neuromodulation (journal to start in
March/2010)
2010 Field Editor International Journal of
Neuropsychopharmacology
2010 Co-Editor ISNR Neurology
2011 Section Editor The All Results Journal of Biology
2011 Associate Editor International Journal of
Neuropsychopharmacology
2011 Associate Editor Expert Medical Review Journal
Honors and Prizes
2004 Travel award to the 8th
International
conference of
Parkinson’s Disease
MDS
2006-2007 National Pancreas
Foundation Award
National Pancreas Foundation
2006-2007 Jorge Paulo Lemann
Fellowship
Harvard University
2007 Travel award University of Sao Paulo Program of visiting
professor
2007-2010 Scientist Development
Award
American Heart Association
2007-2008 Small Science Award CIMIT
2007 Australia-Harvard
Fellowship Award
Harvard Club of Australia
Foundation
8
2007 Einstein Award -
Clinical Medicine
Albert Einstein - Israel - Hospital
2008-2009 Small Science Award CIMIT
2009 Top 10 cited papers
(2006-2008)
PAIN (journal)
Report of Funded and Unfunded Projects
Funding Information
Past
2005-2008 Co-investigator NIDDK
R03DK071851
Evaluating pain and applying transcranial magnetic stimulation, analyzing results and writing manuscript
To investigate the mechanisms and effects of repetitive TMS for chronic pain in pancreatitis
2006-2007 PI Foundation - National
Pancreas Foundation
$25,000
Evaluate the effects of rTMS for pain in pancreatic cancer
2006-2007 PI (fellowship grant) Lemann Fellowship -
Harvard University David
Rockefeller Center for Latin
America Studies
$25,000
Fellowship grant – MPH – clinical effectiveness
2006-2007 PI N.I.H. (M01 RR01032) -
Creff/GCRC, N-133
$14,000
To evaluate the analgesic effects of rTMS in pancreatic cancer
2006-2007 Co-PI Company - Northstar $50,000
To evaluate the effects of high-frequency rTMS of the prefrontal cortex for the treatment of PTSD
2007-2008 Co-investigator CIMIT
To provide tDCS expertise to the project
To assess the feasibility of a novel method - Direct Current (DC) carotid body stimulation - to treat
periodic breathing and central sleep apnea (SA)
2007-2008 PI CIMIT $40,000
To assess the anticonvulsive and antiepileptic properties of transcranial direct current stimulation (tDCS)
9
in an animal seizure model
2007-2008 PI Company - Aspect Medical
Systems
$85,000
To investigate the effects of electrical stimulation of the nervous system with EEG in healthy subjects
2007-2011 PI American Heart Association $180,000
To study the neurophysiological effects of tDCS coupled with CIMT in stroke patients
2009 PI David Rockefeller Center
for Latin American Studies -
Harvard University
$5,000
Small grant to organize the I International Symposium in Placebo (in Sao Paulo, Brazil)
2009-2011 Co-PI NIH R21
R21 HD058049-01A2
Role: Expertise on tDCS for the grant
Study to assess cortical modulation for the treatment of chronic pain in spinal cord injury
2009-2011 Consultant NIH R21
R211BS062317-01A2
Consultant
Role: Expertise on tDCS for the grant
Study to assess the effects of tDCS in visuospatial rehabilitation (Recovering Brain Damage by Direct
Current Stimulation)
2009-2010 Consultant CTSA high-tech funding
UL1RR024986 – University
of Michigan
Consultant
MICHR Clinical Trial Planning Program 2009-2010 -“Brain as a Research and Therapeutic Target in
Trigeminal Neuropathic Pain”'
The main goal of this Clinical Trial Planning Proposal is to integrate neuroimaging techniques with non-
invasive brain stimulation for the investigation and modulation of faulty neuromechanisms in patients
with chronic trigeminal neuropathic pain (TNP).
2009-2012 PI R21 NIDDK
1R21DK081773 - 01A1
$286,000
To investigate the central nervous system dysfunction in chronic pelvic pain using magnetic resonance
spectroscopy and tDCS
2008-2012 PI CIMIT $40,000
To investigate the effects of transcranial direct current stimulation combined with functional task training
on motor recovery in traumatic brain injury survivors
2008-2012 PI RJG Foundation (PD
foundation)
$300,000
To investigate the selective modulation of cognitive, affective and motor function by transcranial direct
current stimulation as co-adjuvant therapy in Parkinson’s disease.
2009-2013 PI Christopher and Dana $150,000
10
Reeve Foundation
Investigation of the mechanisms of transcranial direct current stimulation of motor cortex for the
treatment of chronic pain in spinal cord injury
Current
2009-2013 PI CIMIT $40,000
Investigation of a closed-loop system to detect and treat epilepsy
2010-2013 PI Company – Highland
Instruments
$ 140,000
Study to assess behavioral and neurophysiological effects of ultrasound combined with tDCS in
osteoarthritis
2011-2015 PI To Be First AG $16,100
Study to utilize computer modeling to measure the effects of Cranial Electrical Stimulation on the brain.
2011-2015 Co-I Department of Defense $1,750,000
This study aims to evaluate the safety and effect of Huperzine A on measures of executive function,
memory, mood, behavior, functional outcome, and quality of life after moderate to severe TBI, as
compared to placebo.
2011-2012 Co-I MGH Departmental Grant $15,000
This study is investigating the use of tDCS in alleviating chronic pain due to a previous burn injury.
2011-2013 Co-I Coulter Foundation $120,000
This study investigates the use of a specific version of noninvasive brain stimulation (HD-tDCS), which is
more focal than previous versions, for the alleviation of chronic pain due to fibromyalgia syndrome.
2011-2014 Co-I NIDRR 2,100,000
The purpose is to investigate the effects of active tDCS as compared to sham tDCS stimulation for the
relief of chronic pain in spinal cord injury patients.
2011-2014 Co-I Prader-Willi Syndrome
Association
$16,000
This study is investigating the use of noninvasive brain stimulation in the reduction of appetite in
individuals with Prader-Willi Syndrome.
2012-2013 PI Company- Highland
Instruments
$105,000
Effects of non-invasive neurostimulation methods on motor function in Parkinson’s disease patients.
2012-2014 PI Pedal With Pete $25,000
Effects of tDCS in cortical plasticity and motor learning in children with Cerebral Palsy
2013-2014 PI Company- ElMindA $73,188
This is a phase II study investigating the effects of HD-tDCS in fibromyalgia patients
11
2013-2015 PI NIH $343,202.00
This is a phase II study investigating the use of noninvasive brain stimulation methods on motor function
in Parkinson’s disease patients.
2013-2018 PI Company- BrainGear $1,000,000
This study is investigating the optimal parameters of tPCS, as well as the cortical and subcortical
plasticity induced by tPCS
Current Unfunded Projects
2006-2008 P.I./Effects of rTMS in patients with cerebral palsy
2006-2008 P.I./Study of transcranial direct current stimulation for the treatment of pain in
fibromyalgia
2006- Co-P.I./Antidepressant effects of tDCS
2006-2007 P.I./Effects of noninvasive brain stimulation in relieving smoking, cocaine, alcohol and
food cue-provoked craving
2006-2008 Co-P.I./Effects of cortical stimulation with tDCS on cognitive function in Alzheimer's
disease
2007-2008 P.I./Investigation of repetitive transcranial magnetic brain stimulation combined with
movement
2007-2009 P.I./Effect of repetitive transcranial magnetic stimulation on chronic orofacial pain
2007-2009 P.I./Effect of repetitive transcranial direct current stimulation (tDCS) on pain in chronic
migraine
2006-2008 P.I./Therapeutic effect of repetitive transcranial magnetic stimulation after severe stroke: a
study guided by Diffusion Tensor Imaging
2009 P.I./Study to investigate a novel biomarker using cortical excitability for mild traumatic
brain injury in sports
2010 P.I./Study to investigate the role of the motor cortex in pain modulation using
neurophysiological assessments
2010 P.I./Study to investigate the effects of Repetitive Transcranial Magnetic Stimulation and
Transcranial DC Stimulation on Motor Function in Stroke Patients
Report of Local Teaching and Training
Teaching of Students in Courses
2001-2003 Principles of Neuropharmacology
20 Graduate Students
University of Sao Paulo
12 hours/year
2002-2003 Principles of Neurology
24 Other Students
University of Sao Paulo
6 hours/year
2002-2003 Clinical Clerkship – Neurology
24 Medical Students
University of Sao Paulo
24 hours/year
2002-2003 Neurological Exam
30 Medical Students
University of Sao Paulo
3 hours/month for 3 months
2007- Noninvasive Brain Stimulation in Research University of Sao Paulo
12
and Clinical Practice
15 Phd and MSc students
30 hours/month for 1 month
2010- Harvard Language Initiative: Medical
Portuguese
12 HMS students
Harvard medical School
4 hours/month for 1 month
2011- Introduction to Physical Medicine and
Rehabilitation
Harvard Medical School
1 hour/month for 1 month
Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)
2005- Mini-fellowship in noninvasive brain
stimulation
8 Post-doc Students
8 Residents
8 Other Students
Harvard Medical School
12 hours/year
2007- PIH542 - Field Trip to Brazil
15 Graduate Students
40 hours per year
2007- HMS-CME - Principles and Practice of
Clinical Research
50 Post-doc Students
30 hours/year
Laboratory and Other Research Supervisory and Training Responsibilities
2003- Mentoring medical students in research
projects, University of Sao Paulo
4 Medical Students for 25 hrs/year
2004- Mentoring medical students in research
projects, Harvard Medical School/BIDMC
2 Medical Students for 20 hrs/year
2004- PhD student/co-mentoring, University of
Sao Paulo
1 Graduate Student for 40 hrs/year
2006- Mentoring post-doctoral fellows, Harvard
Medical School
6 Fellows for 50 hrs/year
2008- Thesis Advisor, Harvard School Of Public
Health
1 Graduate Student for 10 hrs/year
2009- Thesis Advisor, M.D. Honors in a Special
Field Thesis, Harvard Medical School
1 Medical Student for 50 hrs/year
2011- Thesis Co-advisor – Demort University
(UK)
1 Graduate Student for 10 hrs/year
Formally Supervised Trainees
2004-2006 Paulo S. Boggio / Assistant Professor (Became Laboratory Director in the Psychology
Depto, Mackenzie University, Brazil)
2005 Renata Marcondes / Other - Clinical Fellow (Finished successfully her PhD)
2005 Raphael Boechat / Assistant Professor (Finished successfully his PhD)
2005-2006 Moises Cunha / Other - Clinical Fellow (Became an attending in a large PRM academic
service in Brazil)
2005-2006 Franca Parizi / Other - Clinical Fellow
2005-2006 Roberta Ferrucci / Other - Research Associate (Became an established research in the
tDCS field)
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2006 Sami Bajwa / Other - Medical Student
2006- Asli Dermitas / Other (Returned to her home country and accept a research position in a
large university in Turkey)
2007- Laura Tadini / Research Fellow
2007- Soroush Zaghi / Other (He is being considered for Special Honors at HMS)
2007- Maria Passos / Assistant Professor
2007- Mariana Z Lopes / Other (Became a established research in Minas Gerais, Brazil)
2007- Julie Williams/Research Assistant (She is now a study coordinator at a large research
group at BWH)
2007- Andre Brunoni / Resident (He is now starting his PhD with more than 10 peer-reviewed
papers)
2008- Fernando Carvas / Other
2008- Marcelo Carvas / Other
2008- Mariana Acar / Other
2008- Nadia Bolognini / Assistant Professor
2008- Brittney A. Hultgren / Student
2008- Bruno Carvas / Medical Student
2008- Rasheda El-Nazer / Research Assistant
2008- Bruna Thiele / Medical Student
2009- Lais Oliveira / Medical Student
2009- Larissa Rezende / Medical Student
2009- Marco Bianchi / Medical Student
2009- Debora Duarte / PhD Student
2009- Bruna Berbel / Medical Student
2009- Thaisa Thiele / Medical Student
2009- Brenno Gomes / Medical Student
2009- Rodrigo Leao / Medical Student (as a result of his internship, he published a first author
paper in a prestigious medical device journal)
2009- Marilia Matos / Medical Student
2009- Fabiano Moulin / Neurology Resident
2009- Fabio Feini / Neurology Resident
2009- Lydia Latif / PMR Physician
2009- Nathalia Baptista / Graduate Student (Psychology)
2009- Angela Do Valle / Assistant Professor (Neurophysiology)
2010- Bruno Zanon / Medical Student
2010- Carla Moreira Albhy/ Medical Student
2010- Caio Casella / Medical Student
2010- Samuel Santos / Medical Student
2010- Daniel Pimentel / Post Doctoral Fellow
2010- Joao Amadera / Post Doctoral Fellow
2010- Thais Pimentel / PhD Student
2010- Marcus Santana
2010- Mariana De Mendonca
2010- Ana Maria Roux Cesar
2010- Jorge Da Costa Leite
2010- Sandra Ribeiro Carvalho
2010- Dafne Carralho Andrade
2010- Igor Carmo Borges
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2010- Debora Macea
2010- Richard Chi
2010- Soo Jeong Han
2010- Huashun Cui
2010- Fernando Santos Pinheiro
2010- Manuella Oliveira
2010- Magdalena Volz
2011- Vanessa Suarez Contreras
2011- Andrea Santos Purtilla
2011- Mauricio Villamar
2011- Pakorn Wivatvongvana
2011- Liubiana Arantes de Araujo Regazzoni
2011- Bianca Fernandes Marcondes
Formal Teaching of Peers (e.g., CME and other continuing education courses)
2006-
Clinical Applications of Transcranial Magnetic
Stimulation in Neurology and Psychiatry
Course: Transcranial Magnetic Stimulation
Harvard, CME
2
Harvard Medical School
2008- (1) Selection of the Questions
(2) Statistical Tests
(3) Other Issues in Statistics I
(4) Other Issues in Statistics II
Course: Principles and Practice of Clinical Research,
Harvard, CME
4
Harvard Medical School
Local Invited Presentations
2006- A novel approach for the treatment of visceral pain/Invited lecture
General Clinical Research Ctr, Beth Israel Deaconess Medical Center
2006- Clinical use of noninvasive brain stimulation for the treatment of chronic pain/Seminar
Beth Israel Deaconess Medical Center
2008- Modulating brain activity with an old, simple and powerful technique of noninvasive brain
stimulation- transcranial direct current stimulation/Invited lecture
Behavioral Neuroscience Seminar, Harvard Medical School
2008- The placebo effect in Parkinson's Disease/Grand Rounds
Harvard Medical School
2009- Noninvasive brain stimulation for the treatment of chronic pain/Grand Rounds
Boston Pain Care Center, Boston, MA
2010- Therapeutic application of transcranial magnetic stimulation in stroke: challenges and
future directions / Grand Rounds
McLean Hospital, Harvard Medical School, Belmont, MA
15
2010- Transcranial Direct Stimulation for Pain Modulation
Center for Pain -- Beth Israel Deaconness Hospital, Boston, MA
2011- Collaboration with Brazil: Ad distance learning program in clinical research and projects
exploring neuroplasticity in rehabilitation.
Harvard University / David Rockefeller Center for Latin American Studies -- Boston, MA
2011- Updates in Clinical Research: Principals and Practice of Clinical Research: Clinical
Research methodology changes over the last 60 years – Harvard Medical School &
University Hospital Coimbra, Coimbra, Portugal
2011- Updates on the mechanisms of chronic pain: exploring novel non-pharmacological
treatments—University of Cuenca, Cuenca, Ecuador
2011- Symposium about transcranial Nueruomodulation in neuroscience: Diagnosis and
Treatment – University of Rio Grande do Sul, Porto Alegre, Sao Paulo
2011- TMS (Transcranial Magnetic Stimulation) in Depression
Day of Functional Neurosurgery and Pain Management - Hospital 9 de Julho Center of
Pain and Functional Neurosurgery - Sao Paulo, Brazil
Report of Regional, National and International Invited Teaching and
Presentations
Invited Presentations and Courses
National
2007- A Powerful Neuromodulatory Tool for the Treatment of Chronic Pain/Visiting
Professorship
Beaumont Hospital, Detroit, Michigan
2008- Noninvasive Brain Stimulation as a Neuromodulatory Approach: review on the clinical
and neurophysiological effects/Plenary Presentation
ISNR - San Antonio, Texas
2009- Transcranial Direct Current Stimulation (tDCS): putative mechanisms of action and
clinical effects of a simple and powerful method of brain stimulation /Plenary Presentation
ISNR - Indianapolis, Indiana
2009- Electrical Stimulation in Neurologic Rehabilitation: pain and epilepsy / Invited Speaker /
Electrical Stimulation in Neurologic Rehabilitation
A Symposium Sponsored by: The Neuro-Cognitive Rehabilitation Research Network
(NCRRN) and The Center for Experimental Neurorehabilitation Training (CENT)
Philadelphia, Pennsylvania
2009- Basic Practical and Theoretical Principles of Transcranial Direct Current Stimulation / 4-
hour workshop course (course director and speaker)
University of Washington (Department of PMR)
16
Seattle, Washington
2009- Clinical Use of Transcranial Direct Current Stimulation, Neuromodulation and Motor
Training / Practical Presentation/Workshop
Accelerating Healthcare Solutions through Technology – CIMIT Innovation Congress
2009
Boston, MA
2009- Research Methodology for Acupuncture Research (Post-Graduation course) / Invited
Speaker (via video-conference)
Sao Paulo, Brazil
2009- Industry Standardization of GCP Investigator Training (case study of a collaborative
learning model) / Invited Presentation
Clinical Training Forum 2009
Boston, MA
2010- Enhancing Brain Plasticity and Rehabilitation Outcomes through Neuro-Imaging and
NIBS / Invited Presentation
Brain Injury Rehabilitation Conference 2010
San Diego, CA
2010- Effects of transcranial magnetic stimulation and transcranial direct current stimulation on
cognitive function / I Symposium of Neuropsychology of Frontal Lobe (I Simposio de
Neuropsicologica do Lobo Frontal), 2010 (via video-conference)
Curitiba, Brazil
2010- Current and Future Applications of Non-Invasive Brain Stimulation in Rehabilitation /
Non-Invasive Brain Stimulation Techniques
AAPMR Conference
Seattle, WA
2010- Introducing the course Principles and Practice of Clinical Research (PPCR) – Department
of Continuing Education at Harvard Medical School / Groundbreaking in Clinical
Research: An Overview of the PPCR Course
4th
International Interdisciplinary Symposium of Residency, Specialization & Post-
Graduation (R&E-MED)
Minas Gerais Medical Association convention center, Belo Horizonte, Brazil
2010- Transcranial Magnetic Stimulation: Current and Future Applications
2010 NANS Annual Meeting
Las Vegas, Nevada
2010- Investigating The Mechanisms Of Non-Invasive Brain Stimulation For The Treatment Of
Pain In Spinal Cord Injury: Preliminary Study With Healthy Controls
Christopher & Dana Reeve Foundation Spinal Cord Symposium
Chandler, AZ
17
2010- Brazil Studies Program Seminar
The Health System in Brazil and Challenges in Clinical Research
Cambridge, MA
2011- Law and Memory Conference
Brain activity and false memories: insights from noninvasive brain stimulation studies
Stanford University
Stanford, CA
2011- Critical analysis of scientific articles in orthopedic surgery
V Inter-institutional Course of Knee Surgery - Instituto de Ensino e Pesquisa do Hospital
Sirio Libanes
Sao Paulo, Brazil
2011- Post Graduate Program in Physical Therapy Keynote speech
Non-invasive brain stimulation: current clinical use and future perspectives
Federal University of Pernambuco
Recife, Brazil
2011- AAPM&R Annual Assembly & Technical Exhibition – two talks:
Novel Therapies in Rehabilitation: Non-Invasive Techniques of Brain Stimulation-
Clinical Evidence and Future Perspectives and Non-invasive Brain Stimulation Techniques
Workshop
Orlando, FL
2012- Spinal Cord Injury Model Systems Research: Noninvasive Transcranial Stimulation in the
Treatment of Pain in Spinal Cord Injury
Rebuilidng Lives: New Advances in Trauma Rehabilitation Conference
Spaulding Rehab Hospital, Boston, MA, May, 2012
2012- Noninvasive nonpharmacological approach to modulate cognition and decision making in
addiction.
American College of Neuropsychopharmacology 51st annual meeting
Hollywood, Florida, December, 2012
2013- Goddard House Dinner Lecture
Parkinson’s Disease: Next Generation Treatments and Technologies
Brookline, MA, April, 2013
2013- Future Directions and Challenges Soterix Medical East 2013
Workshops on tDCS and HD tDCS
Burke Rehab Hospital
White Plains, NY, April, 2013
2013- ASIA Conference
The Application of tDCS on Chronic Neuropathic Pain in SCI
Chicago, IL, May, 2013
18
International
2003-2005 Brain Plasticity Symposium/Invited Lecture
FIEO University (Sao Paulo, Brazil)
2004- Innovative Non-pharmacological Treatments in Mood Disorders: Transcranial Magnetic
Stimulation (TMS) and Vagus Nerve Stimulation/Invited Lecture
Belgian College of Neuropsychopharmacology and Biological Psychiatry (Liege,
Belgium)
2004-2005 Basic Principles of Non-invasive Brain Stimulation/Invited Lecture
Federal University of Pernambuco (Brazil)
2006- International Workshop on Neuromodulation/Invited Lecture
Capital University of Medical Sciences (China)
2006- International Workshop on New Techniques for the Clinical Psychiatrist/Invited Lecture
International Society for Affective Disorders (Milan, Italy)
2007- Noninvasive Brain Stimulation in Rehabilitation/Invited Lecture
University of Sao Paulo-Physical Medicine Department-(Sao Paulo, Brazil)
2007- Use of Non-invasive Brain Stimulation in the Clinical Practice/Invited Lecture
Hospital 9 de Julho (Sao Paulo, Brazil)
2007- Neuromodulation for Chronic Pain/Plenary presentation
Italian Society of Clinical Neurophysiology
Rome, Italy
2007- The Use of an Old, Simple and Powerful Neuromodulatory Tool in Psychiatry:
Transcranial Direct Current Stimulation/Invited Lecture
University of Munich – Munich, Germany
2007- Clinical Use of Transcranial Direct Current Stimulation/Invited Lecture
Guttman Institut (Barcelona, Spain)
2007- An Old, Simple and Powerful Neuromodulatory Tool : transcranial direct current
stimulation/Invited Lecture
University of Montreal – Montreal, Canada
2008- Mechanisms of Action of Transcranial Cortical Stimulation/Plenary Presentation
Société de Neurophysiologie (Paris, France)
2008 Recent Findings and Insights from Clinical and Animal Studies / Invited Presentation
The First International tDCS Club (Milan, Italy)
2008- Risk of Seizures Associated with rTMS/Invited Lecture
Clinical Neurophysiology Society (Siena, Italy)
19
2008- Use of tDCS for the Treatment of Major Depression/Invited Lecture
CINP (Munich, Germany)
2008 Therapeutic Potential of rTMS/tDCS/extradural Stimulation in Other Neuropsychiatric
disorders/ Plenary Presentation
University of Gottingen (Gottingen, Germany)
2008- Noninvasive Brain Stimulation as a Neuromodulatory Approach for
Rehabilitation/Visiting Professorship
Universita di Milano-Bicocca (Milan, Italy)
2008- Use of tDCS for Motor Recovery in Stroke/Visiting Professorship
Policlinico Universitario Agostino Gemelli (Rome, Italy)
2008- An Old, Simple and Powerful Neuromodulatory Tool: transcranial direct current
stimulation/Visiting Professorship
Black Dog Institute - University of New South Wales (Australia)
2009- Use of Transcranial Magnetic Stimulation for the Treatment of Major Depression/ Plenary
Presentation
University Estadual of Paraiba (Paraiba, Brazil)
2009- Noninvasive Methods of Brain Stimulation/Plenary Presentation
Psychology Department, Mackenzie University (Sao Paulo, Brazil)
2009- New Perspectives for Clinical Research in PRM / Course Faculty
Congress Course - 5th World Congress of the ISPRM (Istanbul, Turkey)
2009- Scientific Writing / Course Director
Congress Course - 5th World Congress of the ISPRM (Istanbul, Turkey)
2009- Challenges for Manuscript Writing - XX Congresso Mineiro de Cardiologia (Mineiro
Congress of Cardiology)/ Plenary Presentation
(Minas Gerais, Brazil)
2009- Noninvasive Methods of Brain Stimulation - XXII Congresso Brasileiro de Medicina
Fisica e Reabilitacao (XXII Brazilian Congress of Physical Medicine and Rehabilitation) /
Plenary Presentation
(Sao Paulo, Brazil)
2009- A Simple and Powerful Technique of Noninvasive Brain Stimulation: transcranial direct
current stimulation / Grand Round
Faculté de médecine, neurochirurgie / Université de Sherbrooke (Montreal, Canada)
2010- Other Techniques Using Electrical Stimulation with Weak Currents (tACS) / Plenary
Presentation (II International Symposium in Neuromodulation)
Sao Paulo, Brazil
20
2010- Non-invasive Brain Stimulation in Chronic Pain / Plenary Presentation (II International
Symposium in Neuromodulation)
Sao Paulo, Brazil
2010- Non-invasive Brain Stimulation in Neurology / Invited Speaker (Santa Casa Medical
School)
Sao Paulo, Brazil
2010- Neuromodulation with Magnetic Fields and Electric Currents of Weak Intensity / Plenary
Presentation (I International Symposium in Prefrontal Cortex)
Vitoria, Brazil
2010- Talks: Transcranial Magnetic Stimulation for the Treatment of Major Depression
Transcranial Magnetic Stimulation in Parkinson’s disease
Transcranial Magnetic Stimulation in Stroke Recovery
Plenary Presentations (Beijing Transcranial Magnetic Stimulation Conference)
Beijing, China
2010- Talks: Cortical Excitability Measurements with Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation: State of Art and Future Developments
Transcranial Magnetic Stimulation as a Clinical Tool
Basic Principles of Transcranial Direct Current Stimulation
(Jornada de Brasileira de Neurofisiologia Clinica)
Indaiatuba, Brazil
2010- Transcranial magnetic stimulation - cognitive modulation
(Estimulação magnética transcraniana (TMS) - Modulação cognitiva com técnicas de
neuromodulação)
CHRONOS 2010 - International Conference on Aging
Sao Paulo, Brazil, August, 2010
2010- Brain activity and salutogenesis - modulating cerebral activity with TMS
(Atividade cerebral e salutogenesis - Modulando a atividade cerebral para produzir
saúde)
CHRONOS 2010 - International Conference on Aging
Sao Paulo, Brazil, August, 2010
2010- Transcranial Direct Current Stimulation (tDCS): Principles and Applications
Recent Advances in Brain Stimulation (RABS) Conference
Montreal, Canada, October, 2010
2010- Changes in clinical trials methodology over time: a systematic review of six decades of
research in psychopharmacology
UNIDADE NÃO INVASIVA DE ESTIMULAÇÃO CEREBRAL UNIEC – Programa de
inauguração
Portugal, November, 2010
21
2010- Measuring and Enhancing Neuroplasticity with Brain Stimulation in Rehabilitation
XXII Brazilian Congress of Physical Medicine and Rehabilitation
Sao Paulo, Brazil
2011- Development and future challenges of therapeutic non-invasive brain stimulation in
neurology and rehabilitation: from bench to bedside
2011 TMS Summer School
England, May, 2011
2011- Non invasive brain stimulation in neuropathic pain management
International Symposium of Neuroscience
Colombia, July 2011
2011- Transcranial magnetic stimulation in headaches and Craniofacial Algia
Brazilian Symposium and International Meeting on Pain
Brazil, September, 2011
2011- Two talks: Enhancing and measuring plasticity with tDCS and Translating findings from
neurophysiological studies to design optimal tools of neuromodulation in rehabilitation
II International Symposium of Prefrontal Cortex
University of Espirito Santo
Vitoria-ES, Brazil, October, 2011
2011- Planning statistical analysis: the basics
6th
International Symposium on Intensive Care and Emergency Medicine for Latin
America (video conference – Albert Einstein Hospital, Sao Paulo)
Sao Paulo, Brazil, June, 2011
2011- Workshop in Noninvasive Brain Stimulation
33rd
International Conference of the IEEE Engineering in Medicine and Biology Society
(EBMC 11)
Boston, MA, August, 2011
2012- Modulation of neuroplasticity with non-invasive brain stimulation in addiction
Dutch Endo-Neuro-Psycho Meeting
Lunteren, Netherlands, May, 2012
2012- Prefrontal Cortex tDCS stimulation via a Combined High Definition and Conventional
Electrode Montage: A FEM Modeling Study
34th
Annual International IEEE EMBS Conference
San Diego, California, August 2012
2012- The basics of neuroimaging and brain interference techniques
14th
World Congress on Pain
Milan, Italy, August 2012
22
2012- Recent Advances in Brain Stimulation: The debate Series
Douglas Hall, University of Montreal, Canada
September, 2012
2012- Endogenous I-Opoid System as a Research and Therapeutic Target in Migraine.
Annual Meeting of the American Neurological Association in partnership with Association
of British Neurologists
October, 2012
2013- 2nd
International Conference on Clinical Research: Clinical Research: From Theory to
Practice.
Intercontinental Hotel
Jeddah, Saudi Arabia, March, 2013
2013- Course: Introduction to theoretical and practical aspects of tDCS
Institut Guttman
Barcelona, Spain, June, 2013
Report of Technological and Other Scientific Innovations (Patents)
Development of a portable device of transcranial direct current
stimulation for the treatment of major depression
2006 Jan 1.
Fregni F, Pascual-Leone A,
Boggio P; BIDMC.
PENDING/being processed.
Development of EEG algorithms for an EEG-guided tDCS system to
enhance the antiepileptic effects of tDCS
2006 Jan 1.
Fregni F, Pascual-Leone A,
Schachter S; BIDMC.
PENDING/being processed.
A novel method - Direct Current (DC) carotid body stimulation - to
treat periodic breathing and central sleep apnea (SA) 2007 Jan 1.
Thomas R, Fregni F.
(PENDING).
Transcranial direct current stimulation apparatus and methods
2009 Jun 1.
Hoffman F, Ferris, F Fregni F.
Treatment Methods
(development of a noninvasive brain stimulation system for knee
osteoarthritis) 2011 Oct 6.
Wagner T, Fregni F.
23
Report of Scholarship
Publications
Peer reviewed publications in print or other media
Research investigations
1. Fregni F, Santos CM, Myczkowski ML, Rigolino R, Gallucci-Neto J, Barbosa ER,
Valente KD, Pascual-Leone A, Marcolin MA. Repetitive transcranial magnetic stimulation is as
effective as fluoxetine in the treatment of depression in patients with Parkinson's disease. J Neurol
Neurosurg Psychiatry 2004;75(8):1171-4.
2. Bermpohl F, Fregni F, Boggio PS, Thut G, Northoff G, Otachi PT, Rigonatti SP, Marcolin
MA, Pascual-Leone A. Left prefrontal repetitive transcranial magnetic stimulation impairs
performance in affective go/no-go task. Neuroreport 2005;16(6):615-9.
3. Boggio PS, Fregni F, Bermpohl F, Mansur CG, Rosa M, Rumi DO, Barbosa ER,
Odebrecht Rosa M, Pascual-Leone A, Rigonatti SP, Marcolin MA, Araujo Silva MT. Effect of
repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and
concurrent depression. Mov Disord 2005;20(9):1178-84.
4. Fregni F, Boggio PS, Mansur CG, Wagner T, Ferreira MJ, Lima MC, Rigonatti SP,
Marcolin MA, Freedman SD, Nitsche MA, Pascual-Leone A. Transcranial direct current
stimulation of the unaffected hemisphere in stroke patients. Neuroreport 2005;16(14):1551-5.
5. Fregni F, Boggio PS, Nitsche M, Bermpohl F, Antal A, Feredoes E, Marcolin MA,
Rigonatti SP, Silva MT, Paulus W, Pascual-Leone A. Anodal transcranial direct current
stimulation of prefrontal cortex enhances working memory. Exp Brain Res 2005;166(1):23-30.
6. Fregni F, Monte-Silva KK, Oliveira MB, Freedman SD, Pascual-Leone A, Guedes RC.
Lasting accelerative effects of 1 Hz and 20 Hz electrical stimulation on cortical spreading
depression: relevance for clinical applications of brain stimulation. Eur J Neurosci
2005;21(8):2278-84.
7. Kahn I, Pascual-Leone A, Theoret H, Fregni F, Clark D, Wagner AD. Transient disruption
of ventrolateral prefrontal cortex during verbal encoding affects subsequent memory performance.
J Neurophysiol 2005;94(1):688-98.
8. Mansur CG, Fregni F, Boggio PS, Riberto M, Gallucci-Neto J, Santos CM, Wagner T,
Rigonatti SP, Marcolin MA, Pascual-Leone A. A sham stimulation-controlled trial of rTMS of the
unaffected hemisphere in stroke patients. Neurology 2005;64(10):1802-4.
9. Rumi DO, Gattaz WF, Rigonatti SP, Rosa MA, Fregni F, Rosa MO, Mansur C,
Myczkowski ML, Moreno RA, Marcolin MA. Transcranial magnetic stimulation accelerates the
antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled
study. Biol Psychiatry 2005;57(2):162-6.
10. Theoret H, Halligan E, Kobayashi M, Fregni F, Tager-Flusberg H, Pascual-Leone A.
Impaired motor facilitation during action observation in individuals with autism spectrum
disorder. Curr Biol 2005;15(3):R84-5.
11. Bermpohl F, Fregni F, Boggio PS, Thut G, Northoff G, Otachi PT, Rigonatti SP, Marcolin
MA, Pascual-Leone A. Effect of low-frequency transcranial magnetic stimulation on an affective
go/no-go task in patients with major depression: role of stimulation site and depression severity.
Psychiatry Res 2006;141(1):1-13.
12. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D,
Schlaug G, Northoff G. Attentional modulation of emotional stimulus processing: an fMRI study
using emotional expectancy. Hum Brain Mapp 2006;27(8):662-77.
24
13. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D,
Schlaug G, Northoff G. Dissociable networks for the expectancy and perception of emotional
stimuli in the human brain. Neuroimage 2006;30(2):588-600.
14. . Boggio PS, Alonso-Alonso M, Mansur CG, Rigonatti SP, Schlaug G, Pascual-Leone A,
Fregni F. Hand function improvement with low-frequency repetitive transcranial magnetic
stimulation of the unaffected hemisphere in a severe case of stroke. Am J Phys Med Rehabil
2006;85(11):927-30.
15. Boggio PS, Castro LO, Savagim EA, Braite R, Cruz VC, Rocha RR, Rigonatti SP, Silva
MT, Fregni F. Enhancement of non-dominant hand motor function by anodal transcranial direct
current stimulation. Neurosci Lett 2006;404(1-2):232-6.
16. Boggio PS, Ferrucci R, Rigonatti SP, Covre P, Nitsche M, Pascual-Leone A, Fregni F.
Effects of transcranial direct current stimulation on working memory in patients with Parkinson's
disease. J Neurol Sci 2006;249(1):31-8.
17. Carey JR, Fregni F, Pascual-Leone A. rTMS combined with motor learning training in
healthy subjects. Restor Neurol Neurosci 2006;24(3):191-9.
18. Conforto AB, Fregni F, Puglia P, Jr., Leite Cda C, Yamamoto FI, Coracini KF, Scaff M.
Comparison between digital subtraction angiography and magnetic resonance angiography in
investigation of nonlacunar ischemic stroke in young patients: preliminary results. Arq
Neuropsiquiatr 2006;64(2B):353-8.
19. Dias AE, Barbosa ER, Coracini K, Maia F, Marcolin MA, Fregni F. Effects of repetitive
transcranial magnetic stimulation on voice and speech in Parkinson's disease. Acta Neurol Scand
2006;113(2):92-9.
20. Fregni F, Boggio PS, Bermpohl F, Maia F, Rigonatti SP, Barbosa ER, Pascual-Leone A.
Immediate placebo effect in Parkinson's disease--is the subjective relief accompanied by objective
improvement? Eur Neurol 2006;56(4):222-9.
21. Fregni F, Boggio PS, Lima MC, Ferreira MJ, Wagner T, Rigonatti SP, Castro AW, Souza
DR, Riberto M, Freedman SD, Nitsche MA, Pascual-Leone A. A sham-controlled, phase II trial of
transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord
injury. Pain 2006;122(1-2):197-209.
22. Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A.
Treatment of major depression with transcranial direct current stimulation. Bipolar Disord
2006;8(2):203-4.
23. Fregni F, Boggio PS, Nitsche MA, Rigonatti SP, Pascual-Leone A. Cognitive effects of
repeated sessions of transcranial direct current stimulation in patients with depression. Depress
Anxiety 2006;23(8):482-4.
24. Fregni F, Boggio PS, Santos MC, Lima M, Vieira AL, Rigonatti SP, Silva MT, Barbosa
ER, Nitsche MA, Pascual-Leone A. Noninvasive cortical stimulation with transcranial direct
current stimulation in Parkinson's disease. Mov Disord 2006;21(10):1693-702.
25. Fregni F, Boggio PS, Valle AC, Otachi P, Thut G, Rigonatti SP, Marcolin MA, Fecteau S,
Pascual-Leone A, Fiore L, Valente K. Homeostatic effects of plasma valproate levels on
corticospinal excitability changes induced by 1Hz rTMS in patients with juvenile myoclonic
epilepsy. Clin Neurophysiol 2006;117(6):1217-27.
26. Fregni F, Boggio PS, Valle AC, Rocha RR, Duarte J, Ferreira MJ, Wagner T, Fecteau S,
Rigonatti SP, Riberto M, Freedman SD, Pascual-Leone A. A sham-controlled trial of a 5-day
course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke
patients. Stroke 2006;37(8):2115-22.
27. Fregni F, Gimenes R, Valle AC, Ferreira MJ, Rocha RR, Natalle L, Bravo R, Rigonatti
SP, Freedman SD, Nitsche MA, Pascual-Leone A, Boggio PS. A randomized, sham-controlled,
25
proof of principle study of transcranial direct current stimulation for the treatment of pain in
fibromyalgia. Arthritis Rheum 2006;54(12):3988-98.
28. Fregni F, Marcolin MA, Myczkowski M, Amiaz R, Hasey G, Rumi DO, Rosa M,
Rigonatti SP, Camprodon J, Walpoth M, Heaslip J, Grunhaus L, Hausmann A, Pascual-Leone A.
Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation. Int J
Neuropsychopharmacol 2006;9(6):641-54.
29. Fregni F, Ono CR, Santos CM, Bermpohl F, Buchpiguel C, Barbosa ER, Marcolin MA,
Pascual-Leone A, Valente KD. Effects of antidepressant treatment with rTMS and fluoxetine on
brain perfusion in PD. Neurology 2006;66(11):1629-37.
30. Fregni F, Otachi PT, Do Valle A, Boggio PS, Thut G, Rigonatti SP, Pascual-Leone A,
Valente KD. A randomized clinical trial of repetitive transcranial magnetic stimulation in patients
with refractory epilepsy. Ann Neurol 2006;60(4):447-55.
31. Fregni F, Thome-Souza S, Nitsche MA, Freedman SD, Valente KD, Pascual-Leone A. A
controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy. Epilepsia
2006;47(2):335-42.
32. Liebetanz D, Fregni F, Monte-Silva KK, Oliveira MB, Amancio-dos-Santos A, Nitsche
MA, Guedes RC. After-effects of transcranial direct current stimulation (tDCS) on cortical
spreading depression. Neurosci Lett 2006;398(1-2):85-90.
33. Patrizi F, Freedman SD, Pascual-Leone A, Fregni F. Novel therapeutic approaches to the
treatment of chronic abdominal visceral pain. ScientificWorldJournal 2006;6:472-90.
34. Rosa MA, Gattaz WF, Pascual-Leone A, Fregni F, Rosa MO, Rumi DO, Myczkowski M,
Silva MF, Mansur C, Rigonatti SP, Jacobsen Teixeira M, Marcolin MA. Comparison of repetitive
transcranial magnetic stimulation and electroconvulsive therapy in unipolar non-psychotic
refractory depression: a randomized, single-blind study. Int J Neuropsychopharmacol
2006;9(6):667-76.
35. Wagner T, Fregni F, Eden U, Ramos-Estebanez C, Grodzinsky A, Zahn M, Pascual-Leone
A. Transcranial magnetic stimulation and stroke: a computer-based human model study.
Neuroimage 2006;30(3):857-70.
36. Boggio PS, Bermpohl F, Vergara AO, Muniz AL, Nahas FH, Leme PB, Rigonatti SP,
Fregni F. Go-no-go task performance improvement after anodal transcranial DC stimulation of
the left dorsolateral prefrontal cortex in major depression. J Affect Disord 2007;101(1-3):91-8.
37. Boggio PS, Nunes A, Rigonatti SP, Nitsche MA, Pascual-Leone A, Fregni F. Repeated
sessions of noninvasive brain DC stimulation is associated with motor function improvement in
stroke patients. Restor Neurol Neurosci 2007;25(2):123-9.
38. Cappelletti M, Barth H, Fregni F, Spelke ES, Pascual-Leone A. rTMS over the
intraparietal sulcus disrupts numerosity processing. Exp Brain Res 2007;179(4):631-42.
39. Cohen R, Boggio P, Fregni F. An evaluation of factors affecting duration of treatment
with repetitive transcranial magnetic stimulation for depression. Einstein 2007 2007;5(4):368-71.
40. Fecteau S, Knoch D, Fregni F, Sultani N, Boggio P, Pascual-Leone A. Diminishing risk-
taking behavior by modulating activity in the prefrontal cortex: a direct current stimulation study.
J Neurosci 2007;27(46):12500-5.
41. Fecteau S, Pascual-Leone A, Zald DH, Liguori P, Theoret H, Boggio PS, Fregni F.
Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk
during ambiguous decision making. J Neurosci 2007;27(23):6212-8.
42. Fregni F, Liebetanz D, Monte-Silva KK, Oliveira MB, Santos AA, Nitsche MA, Pascual-
Leone A, Guedes RC. Effects of transcranial direct current stimulation coupled with repetitive
electrical stimulation on cortical spreading depression. Exp Neurol 2007;204(1):462-6.
43. Kuo MF, Grosch J, Fregni F, Paulus W, Nitsche MA. Focusing effect of acetylcholine on
26
neuroplasticity in the human motor cortex. J Neurosci 2007;27(52):14442-7.
44. Nair DG, Hutchinson S, Fregni F, Alexander M, Pascual-Leone A, Schlaug G. Imaging
correlates of motor recovery from cerebral infarction and their physiological significance in well-
recovered patients. Neuroimage 2007;34(1):253-63.
45. Ramos-Estebanez C, Merabet LB, Machii K, Fregni F, Thut G, Wagner TA, Romei V,
Amedi A, Pascual-Leone A. Visual phosphene perception modulated by subthreshold crossmodal
sensory stimulation. J Neurosci 2007;27(15):4178-81.
46. Roizenblatt S, Fregni F, Gimenez R, Wetzel T, Rigonatti SP, Tufik S, Boggio PS, Valle
AC. Site-specific effects of transcranial direct current stimulation on sleep and pain in
fibromyalgia: a randomized, sham-controlled study. Pain Pract 2007;7(4):297-306.
47. Rosa MA, Rosa MO, Marcolin MA, Fregni F. Cardiovascular effects of anesthesia in
ECT: a randomized, double-blind comparison of etomidate, propofol, and thiopental. J ECT
2007;23(1):6-8.
48. Valle AC, Dionisio K, Pitskel NB, Pascual-Leone A, Orsati F, Ferreira MJ, Boggio PS,
Lima MC, Rigonatti SP, Fregni F. Low and high frequency repetitive transcranial magnetic
stimulation for the treatment of spasticity. Dev Med Child Neurol 2007;49(7):534-8.
49. Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial
direct current stimulation: a computer-based human model study. Neuroimage 2007;35(3):1113-
24.
50. Bajwa S, Bermpohl F, Rigonatti SP, Pascual-Leone A, Boggio PS, Fregni F. Impaired
interhemispheric interactions in patients with major depression. J Nerv Ment Dis
2008;196(9):671-7.
51. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Wrase J, Schlagenhauf
F, Bauer M, Heinz A, Schlaug G, Northoff G. Novelty seeking modulates medial prefrontal
activity during the anticipation of emotional stimuli. Psychiatry Res 2008;164(1):81-5.
52. Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A,
Fregni F. A randomized, double-blind clinical trial on the efficacy of cortical direct current
stimulation for the treatment of major depression. Int J Neuropsychopharmacol 2008;11(2):249-
54.
53. Boggio PS, Rocha RR, da Silva MT, Fregni F. Differential modulatory effects of
transcranial direct current stimulation on a facial expression go-no-go task in males and females.
Neurosci Lett 2008;447(2-3):101-5.
54. Boggio PS, Sultani N, Fecteau S, Merabet L, Mecca T, Pascual-Leone A, Basaglia A,
Fregni F. Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving:
a double-blind, sham-controlled study. Drug Alcohol Depend 2008;92(1-3):55-60.
55. Boggio PS, Zaghi S, Lopes M, Fregni F. Modulatory effects of anodal transcranial direct
current stimulation on perception and pain thresholds in healthy volunteers. Eur J Neurol
2008;15(10):1124-30.
56. Cappelletti M, Fregni F, Shapiro K, Pascual-Leone A, Caramazza A. Processing nouns
and verbs in the left frontal cortex: a transcranial magnetic stimulation study. J Cogn Neurosci
2008;20(4):707-20.
57. Cardoso EF, Fregni F, Martins Maia F, Boggio PS, Luis Myczkowski M, Coracini K,
Lopes Vieira A, Melo LM, Sato JR, Antonio Marcolin M, Rigonatti SP, Cruz AC, Jr., Reis
Barbosa E, Amaro E, Jr. rTMS treatment for depression in Parkinson's disease increases BOLD
responses in the left prefrontal cortex. Int J Neuropsychopharmacol 2008;11(2):173-83.
58. Fregni F, Liguori P, Fecteau S, Nitsche MA, Pascual-Leone A, Boggio PS. Cortical
stimulation of the prefrontal cortex with transcranial direct current stimulation reduces cue-
provoked smoking craving: a randomized, sham-controlled study. J Clin Psychiatry
27
2008;69(1):32-40.
59. Fregni F, Orsati F, Pedrosa W, Fecteau S, Tome FA, Nitsche MA, Mecca T, Macedo EC,
Pascual-Leone A, Boggio PS. Transcranial direct current stimulation of the prefrontal cortex
modulates the desire for specific foods. Appetite 2008;51(1):34-41.
60. Imamura M, Imamura ST, Kaziyama HH, Targino RA, Hsing WT, de Souza LP, Cutait
MM, Fregni F, Camanho GL. Impact of nervous system hyperalgesia on pain, disability, and
quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum
2008;59(10):1424-31.
61. Rigonatti SP, Boggio PS, Myczkowski ML, Otta E, Fiquer JT, Ribeiro RB, Nitsche MA,
Pascual-Leone A, Fregni F. Transcranial direct stimulation and fluoxetine for the treatment of
depression. Eur Psychiatry 2008;23(1):74-6.
62. Rosa MA, Rosa MO, Belegarde IM, Bueno CR, Fregni F. Recovery after ECT:
comparison of propofol, etomidate and thiopental. Rev Bras Psiquiatr 2008;30(2):149-51.
63. Wagner T, Eden U, Fregni F, Valero-Cabre A, Ramos-Estebanez C, Pronio-Stelluto V,
Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial magnetic stimulation and brain atrophy: a
computer-based human brain model study. Exp Brain Res 2008;186(4):539-50.
64. Boggio P, Oliveira MO, Fecteau S, Cohen RB, Campanha C, Ferreira-Santos E, Meleiro
A, Corchs F, Zaghi S, Pascual-Leone A, Fregni F. Noninvasive brain stimulation with high-
frequency and low-intensity repetitive transcranial magnetic stimulation treatment for
posttraumatic stress disorder. J Clin Psychiatry 2010 Aug;71(8):992-9.
65. Boggio PS, Amancio EJ, Correa CF, Cecilio S, Valasek C, Bajwa Z, Freedman SD,
Pascual-Leone A, Edwards DJ, Fregni F. Transcranial DC stimulation coupled with TENS for the
treatment of chronic pain: a preliminary study. Clin J Pain 2009;25(8):691-5.
66. Valle A, Roizenblatt S, Botte S, Zaghi S, Riberto M, Tufik S, Boggio PS, Fregni F.
Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia:
Results of a randomized, sham-controlled longitudinal clinical trial. Journal of Pain Management
2009;2(3):353-64.
67. Boggio PS, Fregni F, Valasek C, Ellwood S, Chi R, Gallate J, Pascual-Leone A, Snyder
A. Temporal lobe cortical electrical stimulation during the encoding and retrieval phase reduces
false memories. PLoS One 2009;4(3):e4959.
68. Boggio PS, Khoury LP, Martins DC, Martins OE, de Macedo EC, Fregni F. Temporal
cortex direct current stimulation enhances performance on a visual recognition memory task in
Alzheimer disease. J Neurol Neurosurg Psychiatry 2009;80(4):444-7.
69. Boggio PS, Liguori P, Sultani N, Rezende L, Fecteau S, Fregni F. Cumulative priming
effects of cortical stimulation on smoking cue-induced craving. Neurosci Lett 2009;463(1):82-6.
70. Boggio PS, Zaghi S, Fregni F. Modulation of emotions associated with images of human
pain using anodal transcranial direct current stimulation (tDCS). Neuropsychologia
2009;47(1):212-7.
71. Cardoso EF, Maia FM, Fregni F, Myczkowski ML, Melo LM, Sato JR, Marcolin MA,
Rigonatti SP, Cruz AC, Jr., Barbosa ER, Amaro E, Jr. Depression in Parkinson's disease:
convergence from voxel-based morphometry and functional magnetic resonance imaging in the
limbic thalamus. Neuroimage 2009;47(2):467-72.
72. Cohen RB, Boggio PS, Fregni F. Risk factors for relapse after remission with repetitive
transcranial magnetic stimulation for the treatment of depression. Depress Anxiety
2009;26(7):682-8.
73. Fenton B, Fanning J, Palmieri P, Boggio P, Fregni F. A preliminary study of transcranial
direct current stimulation for the treatment of refractory chronic pelvic pain. Brain Stimulation
2009;2(2):103-7.
28
74. Fiquer JT, Boggio PS, Silva MTA, Gorenstein C, Fregni F, Rigonatti SP, Otta E.
Affective changes in depressed patients treated with Transcranial Direct Current Stimulation.
Temas em Psicologia 2009;15(2):149-59.
75. Martin PI, Naeser MA, Ho M, Doron KW, Kurland J, Kaplan J, Wang Y, Nicholas M,
Baker EH, Fregni F, Pascual-Leone A. Overt naming fMRI pre- and post-TMS: Two nonfluent
aphasia patients, with and without improved naming post-TMS. Brain Lang 2009;111(1):20-35.
76. Soler D, Kumru H, Vidal J, Pelayo R, Tormos J, Navarro X, Fregni F, Pascual-Leone A.
Referred sensations and neuropathic pain following spinal cord injury. PAIN 2010 Jul;150(1):192-
8.
77. Boggio PS, Campanha C, Valasek CA, Fecteau S, Fregni F. Modulation of decision-
making in a gambling task in older adults with transcranial direct current stimulation (tDCS).
European Journal of Neuroscience 2010;31(3):593-7.
78. Cardoso E, Fregni F, Maia F, Melo LM, Sato J, Cruz AC, Bianchi E, Fernandes D,
Monteiro M, Barbosa ER, Amaro E. Abnormal visual activation in Parkinson’s disease patients.
Movement Disorders 2010 Aug 15;25(11):1590-6.
79. Williams JA, Pascual-Leone A, Fregni F. Interhemispheric Modulation Induced by
Cortical Stimulation and Motor Training. Physical Therapy 2010 Mar; 90(3):398-410.
80. Datta A, Bikson M, Fregni F. Transcranial direct current stimulation in patients with skull
defects and skull plates: High-resolution computational FEM study of factors altering cortical
current flow. Neuroimage. 2010 Oct 1;52(4):1268-78.
81. Zaghi S, de Freitas Rezende L, Machado de Oliveira L, El-Nazer R, Menning S, Tadini L,
Fregni F. Inhibition of motor cortex excitability with 15Hz transcranial alternating current
stimulation (tACS). Neuroscience Letters 2010;479(3):211-4.
82. Boggio PS, Zaghi S, Villani AB, Fecteau S, Pascual-Leone A, Fregni F. Modulation of
risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral
prefrontal cortex (DLPFC). Drug Alcohol Depend 2010 Dec 1:112(3):220-5.
83. Bolognini N, Fregni F, Casati C, Olgiati E, Vallar G. Brain polarization of parietal cortex
augments training-induced improvement of visual exploratory and attentional skills. Brain Res
2010 Aug 19;1349:76-89.
84. Cohen RB, Brunoni AR, Boggio PS, Fregni F. Clinical predictors associated with
duration of repetitive transcranial magnetic stimulation treatment for remission in bipolar
depression: a naturalistic study. J Nerv Ment Dis 2010 Sep;198(9):679-81.
85. Soler MD, Kumru H, Pelayo R, Vidal J, Tormos JM, Fregni F, Navarro X, Pascual-Leone
A. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain
in spinal cord injury. Brain 2010 Sep;133(9):2565-77.
86. Tadini L, El-Nazer R, Brunoni
A, Williams
J, Carvas
M, Boggio
P, Priori
A, Pascual-Leone
A, Fregni F. Cognitive, Mood and EEG effects of noninvasive cortical stimulation with weak
electrical currents. J ECT. 2011 Jun;27(2):134-40.
87. Chi RP, Fregni F, Snyder AW. Visual memory improved by non-invasive brain
stimulation. Brain Res 2010 Sep 24;1353:168-75.
88. Fregni F, Potvin K, Dasilva D, Wang X, Lenkinski RE, Freedman SD, Pascual-Leone A.
Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for
visceral pain. Eur J Pain 2011 Jan:15(1):53-60.
89. Mahmoudi H, Haghighi AB, Petramfar P, Jahanshahi S, Salehi Z, Fregni F. Transcranial
direct current stimulation: electrode montage in stroke. Disabil Rehabil. 2011;33(15-16):1383-8.
90. San-Juan D, Calcáneo Jde D, González-Aragón MF, Bermúdez Maldonado L, Avellán
AM, Argumosa EV, Fregni F. Transcranial direct current stimulation in adolescent and adult
Rasmussen's encephalitis. Epilepsy Behav. 2011 Jan;20(1):126-31.
29
91. Bueno VF, Brunoni AR, Boggio PS, Bensenor IM, Fregni F. Mood and cognitive effects
of transcranial direct current stimulation in post-stroke depression. Neurocase. 2011 Jan 6:1-5.
92. Bae EH, Theodore WH, Fregni F, Cantello R, Pascual-Leone A, Rotenberg A. An
estimate of placebo effect of repetitive transcranial magnetic stimulation in epilepsy. Epilepsy
Behav. 2011 Feb;20(2):355-9.
93. Mendonca ME, Santana MB, Baptista AF, Datta A, Bikson M, Fregni F, Araujo CP.
Transcranial DC stimulation in fibromyalgia: optimized cortical target supported by high-
resolution computational models. J Pain. 2011 May;12(5):610-7. doi: 10.1016/j.jpain.2010.12.015.
94. Shin BM, Han SJ, Jung JH, Kim JE, Fregni F. Effect of mild cognitive impairment on
balance. J Neurol Sci. 2011 Jun 15;305(1-2):121-5.
95. Riberto M, Marcon Alfieri F, Monteiro de Benedetto Pacheco K, Dini Leite V,Nemoto
Kaihami H, Fregni F, Rizzo Battistella L. Efficacy of transcranial direct current stimulation
coupled with a multidisciplinary rehabilitation program for the treatment of fibromyalgia. Open
Rheumatol J. 2011;5:45-50.
96. Fernandes TL, Protta TR, Fregni F, Neto RB, Pedrinelli A, Camanho GL, Hernandez AJ.
Isokinetic muscle strength and knee function associated with double femoral pin fixation and
fixation with interference screw in anterior cruciate ligament reconstruction. Knee Surg Sports
Traumatol Arthrosc. 2011 Jun 28.
97. Nakamura-Palacios EM, de Almeida Benevides MC, da Penha Zago-Gomes M, deOliveira
RW, de Vasconcellos VF, de Castro LN, da Silva MC, Ramos PA, Fregni F. Auditory event-
related potentials (P3) and cognitive changes induced by frontal direct current stimulation in
alcoholics according to Lesch alcoholism typology. Int J Neuropsychopharmacol. 2011 Jul 22:1-
16.
98. Boggio PS, Ferrucci R, Mameli F, Martins D, Martins O, Vergari M, Tadini L, Scarpini E,
Fregni F, Priori A. Prolonged visual memory enhancement after direct current stimulation in
Alzheimer's disease. Brain Stimul. 2011 Jul 27.
99. Giacobbe V, Volpe BT, Thickbroom GW, Fregni F, Pascual-Leone A, Krebs HI, Edwards
DJ. Reversal of TMS-induced motor twitch by training is associated with a reduction in
excitability of the antagonist muscle. J Neuroeng Rehabil. 2011 Aug 24;8:46.
100. Faber M, Vanneste S, Fregni F, De Ridder D. Top down prefrontal affective modulation
of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex. Brain Stimul. 2011
Oct 5.
101. Campanhã C, Minati L, Fregni F, Boggio PS. Responding to unfair offers made by a
friend: neuroelectrical activity changes in the anterior medial prefrontal cortex. J Neurosci. 2011
Oct 26;31(43):15569-74.
102. Ladeira A, Fregni F, Campanhã C, Valasek CA, De Ridder D, Brunoni AR, Boggio PS.
Polarity
103. Suemoto CK, Nitrini R, Grinberg LT, Ferretti RE, Farfel JM, Leite RE, Menezes PR,
Fregni F, Jacob-Filho W, Pasqualucci CA; Brazilian Aging Brain Study Group. Atherosclerosis
and dementia: a cross-sectional study with pathological analysis of the carotid arteries. Stroke.
2011 Dec;42(12):3614-5.
104. Leite J, Carvalho S, Fregni F, Gonçalves ÓF. Task-specific effects of tDCS-induced
cortical excitability changes on cognitive and motor sequence set shifting performance. PLoS One.
2011;6(9):e24140.
105. Naeser MA, Martin PI, Theoret H, Kobayashi M, Fregni F, Nicholas M, Tormos JM,
Steven MS, Baker EH, Pascual-Leone A. TMS suppression of right pars triangularis, but not pars
opercularis, improves naming in aphasia. Brain Lang. 2011 Dec;119(3):206-13.
106. Bolognini N, Vallar G, Casati C, Latif LA, El-Nazer R, Williams J, Banco E, Macea DD,
30
Tesio L, Chessa C, Fregni F. Neurophysiological and behavioral effects of tDCS combined with
constraint-induced movement therapy in poststroke patients. Neurorehabil Neural Repair. 2011
Nov-Dec;25(9):819-29.
107. Volz MS, Mendonca M, Pinheiro FS, Cui H, Santana M, Fregni F. Dissociation of motor
task-induced cortical excitability and pain perception changes in healthy volunteers. PLoS One.
2012;7(3):e34273.
108. Schneider JC, Trinh NH, Selleck E, Fregni F, Salles SS, Ryan CM, Stein J. The long-term
impact of physical and emotional trauma: the station nightclub fire. PLoS One.
2012;7(10):e47339.
109. Fecteau S, Boggio P, Fregni F, Pascual-Leone A. Modulation of untruthful responses with
non-invasive brain stimulation. Front Psychiatry. 2012;3:97.
110. DosSantos MF, Love TM, Martikainen IK, Nascimento TD, Fregni F, Cummiford C,
Deboer MD, Zubieta JK, Dasilva AF. Immediate effects of tDCS on the μ-opioid system of a
chronic pain patient. Front Psychiatry. 2012;3:93.
111. Fernandes TL, Protta TR, Fregni F, Neto RB, Pedrinelli A, Camanho GL, Hernandez AJ.
Isokinetic muscle strength and knee function associated with double femoral pin fixation and
fixation with interference screw in anterior cruciate ligament reconstruction. Knee Surg Sports
112. Traumatol Arthrosc. 2012 Feb;20(2):275-80.
113. Gladwin TE, den Uyl TE, Fregni FF, Wiers RW. Enhancement of selective attention by
tDCS: interaction with interference in a Sternberg task. Neurosci Lett. 2012 Mar 14;512(1):33-7.
114. Hsing WT, Imamura M, Weaver K, Fregni F, Azevedo Neto RS. Clinical effects of scalp
electrical acupuncture in stroke: a sham-controlled randomized clinical trial. J Altern Complement
Med. 2012 Apr;18(4):341-6.
115. Stefani LC, Torres IL, de Souza IC, Rozisky JR, Fregni F, Caumo W. BDNF as an effect
modifier for gender effects on pain thresholds in healthy subjects. Neurosci Lett. 2012 Apr
11;514(1):62-6.
116. Reidler JS, Mendonca ME, Santana MB, Wang X, Lenkinski R, Motta AF, Marchand S,
Latif L, Fregni F. Effects of motor cortex modulation and descending inhibitory systems on pain
thresholds in healthy subjects. J Pain. 2012 May;13(5):450-8.
117. Nakamura-Palacios EM, de Almeida Benevides MC, da Penha Zago-Gomes M, de
Oliveira RW, de Vasconcellos VF, de Castro LN, da Silva MC, Ramos PA, Fregni F. Auditory
event-related potentials (P3) and cognitive changes induced by frontal direct current stimulation in
alcoholics according to Lesch alcoholism typology. Int J Neuropsychopharmacol. 2012
Jun;15(5):601-16.
118. Plow EB, Obretenova SN, Fregni F, Pascual-Leone A, Merabet LB. Comparison of visual
field training for hemianopia with active versus sham transcranial direct cortical stimulation.
Neurorehabil Neural Repair. 2012 Jul-Aug;26(6):616-26.
119. Boggio PS, Ferrucci R, Mameli F, Martins D, Martins O, Vergari M, Tadini L, Scarpini E,
Fregni F, Priori A. Prolonged visual memory enhancement after direct current stimulation in
Alzheimer's disease. Brain Stimul. 2012 Jul;5(3):223-30.
120. Laste G, Caumo W, Adachi LN, Rozisky JR, de Macedo IC, Filho PR, Partata WA, Fregni
F, Torres IL. After-effects of consecutive sessions of transcranial direct current stimulation (tDCS)
in a rat model of chronic inflammation. Exp Brain Res. 2012 Aug;221(1):75-83.
121. Dasilva AF, Mendonca ME, Zaghi S, Lopes M, Dossantos MF, Spierings EL, Bajwa Z,
Datta A, Bikson M, Fregni F. tDCS-induced analgesia and electrical fields in pain-related neural
networks in chronic migraine. Headache. 2012 Sep;52(8):1283-95.
122. Batista-de-Oliveira M, Monte-Silva-Machado KK, Paiva AK, Lima H, Fregni F, Guedes
RC. Favorable and unfavorable lactation modulates the effects of electrical stimulation on brain
31
excitability: a spreading depression study in adult rats. Life Sci. 2012 Sep 24;91(9-10):306-11.
123. Faber M, Vanneste S, Fregni F, De Ridder D. Top down prefrontal affective modulation
of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex. Brain Stimul. 2012
Oct;5(4):492-8.
124. Lapenta OM, Fregni F, Oberman LM, Boggio PS. Bilateral temporal cortex transcranial
direct current stimulation worsens male performance in a multisensory integration task. Neurosci
Lett. 2012 Oct 11;527(2):105-9.
125. Sehn F, Chachamovich E, Vidor LP, Dall-Agnol L, de Souza IC, Torres IL, Fregni F,
Caumo W. Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain
catastrophizing scale. Pain Med. 2012 Nov;13(11):1425-35.
126. Faria P, Fregni F, Sebastião F, Dias AI, Leal A. Feasibility of focal transcranial DC
polarization with simultaneous EEG recording: preliminary assessment in healthy subjects and
human epilepsy. Epilepsy Behav. 2012 Nov;25(3):417-25.
127. Leite J, Carvalho S, Fregni F, Boggio PS, Gonçalves OF. The effects of cross-hemispheric
dorsolateral prefrontal cortex transcranial direct current stimulation (tDCS) on task switching.
Brain Stimul. 2012 Nov 2. [In press]
128. Fernandes TL, Fregni F, Weaver K, Pedrinelli A, Camanho GL, Hernandez AJ. The
influence of femoral tunnel position in single-bundle ACL reconstruction on functional outcomes
and return to sports. Knee Surg Sports Traumatol Arthrosc. 2012 Nov 7. [In press]
129. Schestatsky P, Janovik N, Lobato MI, Belmonte-de-Abreu P, Schestatsky S, Shiozawa P,
Fregni F. Rapid therapeutic response to anodal tDCS of right dorsolateral prefrontal cortex in
acute mania. Brain Stimul. 2012 Nov 7. [In press]
130. Brunoni AR, Ferrucci R, Bortolomasi M, Scelzo E, Boggio PS, Fregni F, Dell'osso B,
Giacopuzzi M, Altamura AC, Priori A. Interactions between transcranial direct current stimulation
(tDCS) and pharmacological interventions in the Major Depressive Episode: Findings from a
naturalistic study. Eur Psychiatry. 2012 Nov 23. [In press]
131. Vidor LP, Torres IL, de Souza IC, Fregni F, Caumo W. Analgesic and Sedative Effects of
Melatonin in Temporomandibular Disorders: A Double-Blind, Randomized, Parallel-Group,
Placebo-Controlled Study. J Pain Symptom Manage. 2012 Nov 27. [In press]
132. Wang S, Yuan J, Guo X, Peng P, Gu H, Niu S, Fregni F, Chen AC, Hu W. Neurochemical
correlates of cognitive dysfunction in patients with leukoaraiosis: a proton magnetic resonance
spectroscopy study. Neurol Res. 2012 Dec;34(10):989-97.
133. Spezia Adachi LN, Caumo W, Laste G, Fernandes Medeiros L, Ripoll Rozisky J, de Souza
A, Fregni F, Torres IL. Reversal of chronic stress-induced pain by transcranial direct current
stimulation (tDCS) in an animal model. Brain Res. 2012 Dec 13;1489:17-26.
134. Brunoni AR, Vanderhasselt MA, Boggio PS, Fregni F, Dantas EM, Mill JG, Lotufo PA,
Benseñor IM. Polarity- and valence-dependent effects of prefrontal transcranial direct current
stimulation on heart rate variability and salivary cortisol. Psychoneuroendocrinology. 2013
Jan;38(1):58-66.
135. Volz MS, Suarez-Contreras V, Mendonca ME, Pinheiro FS, Merabet LB, Fregni F.
Effects of sensory behavioral tasks on pain threshold and cortical excitability. PLoS One.
2013;8(1):e52968.
136. Portilla AS, Bravo GL, Miraval FK, Villamar MF, Schneider JC, Ryan CM, Fregni F. A
feasibility study assessing cortical plasticity in chronic neuropathic pain following burn injury. J
Burn Care Res. 2013 Jan-Feb;34(1):e48-52.
137. Datta A, Dmochowski JP, Guleyupoglu B, Bikson M, Fregni F. Cranial electrotherapy
stimulation and transcranial pulsed current stimulation: a computer based high-resolution
modeling study. Neuroimage. 2013 Jan 15;65:280-7.
32
138. Foerster A, Rocha S, Wiesiolek C, Chagas AP, Machado G, Silva E, Fregni F, Monte-
Silva K. Site-specific effects of mental practice combined with transcranial direct current
stimulation on motor learning. Eur J Neurosci. 2013 Mar;37(5):786-94.
139. Oliveira JF, Zanão TA, Valiengo L, Lotufo PA, Benseñor IM, Fregni F, Brunoni AR.
Acute working memory improvement after tDCS in antidepressant-free patients with major
depressive disorder. Neurosci Lett. 2013 Mar 14;537:60-4.
140. Brunoni AR, Valiengo L, Baccaro A, Zanão TA, de Oliveira JF, Goulart A, Boggio PS,
Lotufo PA, Benseñor IM, Fregni F. The sertraline vs. electrical current therapy for treating
depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry.
2013 Apr;70(4):383-91.
141. Villamar MF, Wivatvongvana P, Patumanond J, Bikson M, Truong DQ, Datta A, Fregni
F. Focal modulation of the primary motor cortex in fibromyalgia using 4×1-ring high-definition
transcranial direct current stimulation (HD-tDCS): immediate and delayed analgesic effects of
cathodal and anodal stimulation. J Pain. 2013 Apr;14(4):371-83.
142. de Brito CM, Garcia AC, Takayama L, Fregni F, Battistella LR, Pereira RM. Bone loss in
chronic hemiplegia: a longitudinal cohort study. J Clin Densitom. 2013 Apr;16(2):160-7.
143. Couto C, de Souza IC, Torres IL, Fregni F, Caumo W. Paraspinal Stimulation Combined
With Trigger Point Needling and Needle Rotation for the Treatment of Myofascial Pain: A
Randomized Sham-controlled Clinical Trial. Clin J Pain. 2013 Apr 25. [In Press]
144. Valiengo L, Benseñor IM, Goulart AC, de Oliveira JF, Zanao TA, Boggio PS, Lotufo PA,
Fregni F, Brunoni AR. THE SERTRALINE VERSUS ELECTRICAL CURRENT THERAPY
FOR TREATING DEPRESSION CLINICAL STUDY (SELECT-TDCS): RESULTS OF THE
CROSSOVER AND FOLLOW-UP PHASES. Depress Anxiety. 2013 Apr 26. [In Press]
145. de Souza Custódio JC, Martins CW, Lugon MD, Fregni F, Nakamura-Palacios EM.
Epidural direct current stimulation over the left medial prefrontal cortex facilitates spatial working
memory performance in rats. Brain Stimul. 2013 May;6(3):261-9.
146. Jensen MP, Sherlin LH, Askew RL, Fregni F, Witkop G, Gianas A, Howe JD, Hakimian S.
Effects of non-pharmacological pain treatments on brain states. Clin Neurophysiol. 2013 May 22.
[In Press]
147. Brunoni AR, Zanao TA, Vanderhasselt MA, Valiengo L, de Oliveira JF, Boggio PS,
Lotufo PA, Benseñor IM, Fregni F. Enhancement of Affective Processing Induced by Bifrontal
Transcranial Direct Current Stimulation in Patients With Major Depression. Neuromodulation.
2013 May 24. [In Press]
148. Brunoni AR, Zanao TA, Ferrucci R, Priori A, Valiengo L, de Oliveira JF, Boggio PS,
Lotufo PA, Benseñor IM, Fregni F. Bifrontal tDCS prevents implicit learning acquisition in
antidepressant-free patients with major depressive disorder. Prog Neuropsychopharmacol Biol
Psychiatry. 2013 Jun 3;43:146-50.
149. Brunoni AR, Kemp AH, Dantas EM, Goulart AC, Nunes MA, Boggio PS, Mill JG,
Lotufo PA, Fregni F, Benseñor IM. Heart rate variability is a trait marker of
major depressive disorder: evidence from the sertraline vs. electric current
therapy to treat depression clinical study. Int J Neuropsychopharmacol. 2013
Oct;16(9):1937-49. doi: 10.1017/S1461145713000497.
150. Lapenta OM, Minati L, Fregni F, Boggio PS. Je pense donc je fais: transcranial
direct current stimulation modulates brain oscillations associated with motor
imagery and movement observation. Front Hum Neurosci. 2013 Jun 6;7:256. doi:
10.3389/fnhum.2013.00256.
151. Volz MS, Medeiros LF, Tarragô Mda G, Vidor LP, Dall'Agnol L, Deitos A,
Brietzke A, Rozisky JR, Rispolli B, Torres IL, Fregni F, Caumo W. The
33
relationship between cortical excitability and pain catastrophizing in myofascial
pain. J Pain. 2013 Oct;14(10):1140-7.
152. Santos MD, Gagliardi RJ, Mac-Kay AP, Boggio PS, Lianza R, Fregni F.
Transcranial direct-current stimulation induced in stroke patients with aphasia:
a prospective experimental cohort study. Sao Paulo Med J. 2013;131(6):422-6.
153. Gonçalves GS, Borges IC, Goes BT, de Mendonça ME, Gonçalves RG, Garcia LB, Sá
KN, Coutinho MR, Castro Filho BG, Fregni F, Baptista AF. Effects of tDCS Induced
Motor Cortex Modulation on Pain in HTLV-1: A Blind Randomized Clinical Trial.
Clin J Pain. 2013 Nov 28. [Epub ahead of print] PubMed PMID: 24300224.
154. Suemoto CK, Apolinario D, Nakamura-Palacios EM, Lopes L, Paraizo Leite RE,
Sales MC, Nitrini R, Brucki SM, Morillo LS, Magaldi RM, Fregni F. Effects of a
Non-focal Plasticity Protocol on Apathy in Moderate Alzheimer's Disease: A
Randomized, Double-blind, Sham-controlled Trial. Brain Stimul. 2013 Oct 25. [In Press]
155. Simis M, Adeyemo BO, Medeiros LF, Miraval F, Gagliardi RJ, Fregni F. Motor
cortex-induced plasticity by noninvasive brain stimulation: a comparison between
transcranial direct current stimulation and transcranial magnetic stimulation.
Neuroreport. 2013 Dec 4;24(17):973-5.
156. Xu J, Fregni F, Brody AL, Rahman AS. Transcranial direct current stimulation
reduces negative affect but not cigarette craving in overnight abstinent smokers.
Front Psychiatry. 2013 Sep 20;4:112.
157. Brunoni AR, Júnior RF, Kemp AH, Lotufo PA, Benseñor IM, Fregni F.
Differential improvement in depressive symptoms for tDCS alone and combined with
pharmacotherapy: an exploratory analysis from The Sertraline Vs. Electrical
Current Therapy For Treating Depression Clinical Study. Int J
Neuropsychopharmacol. 2014 Jan;17(1):53-61.
158. Brunoni AR, Schestatsky P, Lotufo PA, Benseñor IM, Fregni F. Comparison of
blinding effectiveness between sham tDCS and placebo sertraline in a 6-week major
depression randomized clinical trial. Clin Neurophysiol. 2013 Aug 29. pii:
S1388-2457(13)00980-2. doi: 10.1016/j.clinph.2013.07.020. [Epub ahead of print]
PubMed PMID: 23994192.
159. Giacobbe V, Krebs HI, Volpe BT, Pascual-Leone A, Rykman A, Zeiarati G, Fregni
F, Dipietro L, Thickbroom GW, Edwards DJ. Transcranial direct current stimulation
(tDCS) and robotic practice in chronic stroke: the dimension of timing.
NeuroRehabilitation. 2013;33(1):49-56.
160. da Silva MC, Conti CL, Klauss J, Alves LG, do Nascimento Cavalcante HM,
Fregni F, Nitsche MA, Nakamura-Palacios EM. Behavioral effects of transcranial
Direct Current Stimulation (tDCS) induced dorsolateral prefrontal cortex
plasticity in alcohol dependence. J Physiol Paris. 2013 Dec;107(6):493-502. doi:
10.1016/j.jphysparis.2013.07.003. Epub 2013 Jul 25. PubMed PMID: 23891741.
161. Farfel JM, Nitrini R, Suemoto CK, Grinberg LT, Ferretti RE, Leite RE,
Tampellini E, Lima L, Farias DS, Neves RC, Rodriguez RD, Menezes PR, Fregni F,
Bennett DA, Pasqualucci CA, Jacob Filho W; Brazilian Aging Brain Study Group.
Very low levels of education and cognitive reserve: a clinicopathologic study.
Neurology. 2013 Aug 13;81(7):650-7. doi: 10.1212/WNL.0b013e3182a08f1b. Epub 2013
Jul 19. PubMed PMID: 23873971; PubMed Central PMCID: PMC3775692.
34
162. Wagner T, Eden U, Rushmore J, Russo CJ, Dipietro L, Fregni F, Simon S, Rotman
S, Pitskel NB, Ramos-Estebanez C, Pascual-Leone A, Grodzinsky AJ, Zahn M,
Valero-Cabré A. Impact of brain tissue filtering on neurostimulation fields: A
modeling study. Neuroimage. 2014 Jan 15;85 Pt 3:1048-57. doi:
10.1016/j.neuroimage.2013.06.079. Epub 2013 Jul 10. PubMed PMID: 23850466.
Other peer-reviewed publications
163. Fregni F, DaSilva D, Potvin K, Ramos-Estebanez C, Cohen D, Pascual-Leone A,
Freedman SD. Treatment of chronic visceral pain with brain stimulation. Ann Neurol
2005;58(6):971-2.
164. Fregni F, Pascual-Leone A. Transcranial magnetic stimulation for the treatment of
depression in neurologic disorders. Curr Psychiatry Rep 2005;7(5):381-90.
165. Fregni F, Schachter SC, Pascual-Leone A. Transcranial magnetic stimulation treatment for
epilepsy: can it also improve depression and vice versa? Epilepsy Behav 2005;7(2):182-9.
166. Fregni F, Simon DK, Wu A, Pascual-Leone A. Non-invasive brain stimulation for
Parkinson's disease: a systematic review and meta-analysis of the literature. J Neurol Neurosurg
Psychiatry 2005;76(12):1614-23.
167. Naeser MA, Martin PI, Nicholas M, Baker EH, Seekins H, Helm-Estabrooks N, Cayer-
Meade C, Kobayashi M, Theoret H, Fregni F, Tormos JM, Kurland J, Doron KW, Pascual-Leone
A. Improved naming after TMS treatments in a chronic, global aphasia patient--case report.
Neurocase 2005;11(3):182-93.
168. Naeser MA, Martin PI, Nicholas M, Baker EH, Seekins H, Kobayashi M, Theoret H,
Fregni F, Maria-Tormos J, Kurland J, Doron KW, Pascual-Leone A. Improved picture naming in
chronic aphasia after TMS to part of right Broca's area: an open-protocol study. Brain Lang
2005;93(1):95-105.
169. Boggio PS, Fregni F, Rigonatti SP, Marcolin MA, Silva MT. [Transcranial magnetic
stimulation in neuropsychology: new horizons for brain research]. Rev Bras Psiquiatr
2006;28(1):44-9.
170. Fregni F, Marcondes R, Boggio PS, Marcolin MA, Rigonatti SP, Sanchez TG, Nitsche
MA, Pascual-Leone A. Transient tinnitus suppression induced by repetitive transcranial magnetic
stimulation and transcranial direct current stimulation. Eur J Neurol 2006;13(9):996-1001.
171. Fregni F, Pascual-Leone A. Hand motor recovery after stroke: tuning the orchestra to
improve hand motor function. Cogn Behav Neurol 2006;19(1):21-33.
172. Marcolin MA, Souza Filho JL, Teixeira MJ, Fregni F. Transient visual changes associated
with repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in cases of
major depression. Rev Bras Psiquiatr 2006;28(3):251.
173. Marcondes R, Fregni F, Pascual-Leone A. Tinnitus and brain activation: insights from
transcranial magnetic stimulation. Ear Nose Throat J 2006;85(4):233-4.
174. Alonso-Alonso M, Fregni F, Pascual-Leone A. Brain stimulation in poststroke
rehabilitation. Cerebrovasc Dis 2007;24 Suppl 1:157-66.
175. Edwards DJ, Mastaglia FL, Byrnes ML, Fregni F, Pascual-Leone A, Thickbroom GW.
Supraspinal inputs reduce corticomotor excitability during passive movement: evidence from a
pure sensory stroke. Restor Neurol Neurosci 2007;25(5-6):527-33.
176. Fregni F, Freedman S, Pascual-Leone A. Recent advances in the treatment of chronic pain
with non-invasive brain stimulation techniques. Lancet Neurol 2007;6(2):188-91.
177. Fregni F, Pascual-Leone A. Technology insight: noninvasive brain stimulation in
neurology-perspectives on the therapeutic potential of rTMS and tDCS. Nat Clin Pract Neurol
35
2007;3(7):383-93.
178. Fregni F, Pascual-Leone A, Freedman SD. Pain in chronic pancreatitis: a salutogenic
mechanism or a maladaptive brain response? Pancreatology 2007;7(5-6):411-22.
179. Gross M, Nakamura L, Pascual-Leone A, Fregni F. Has repetitive transcranial magnetic
stimulation (rTMS) treatment for depression improved? A systematic review and meta-analysis
comparing the recent vs. the earlier rTMS studies. Acta Psychiatr Scand 2007;116(3):165-73.
180. Hemond C, Fregni F. Transcranial magnetic stimulation in neurology: what we have
learned from randomized controlled studies. Neuromodulation 2007;10(4):333-44.
181. Negreiros D, Fregni F, Scalco A, . Global aphasia without hemiparesis: stroke or
conversion disorder? Revista de Psiquiatria Clinica 2007;34(1):23-7.
182. Nitsche M, Fregni F. Transcranial Direct Current Stimulation - An Adjuvant Tool for the
Treatment of Neuropsychiatric Diseases? Current Psychiatry Reviews 2007;3(3).
183. Silva G, Miksad R, Freedman SD, Pascual-Leone A, Jain S, Gomes DL, Amancio EJ,
Boggio PS, Correa CF, Fregni F. Treatment of cancer pain with noninvasive brain stimulation. J
Pain Symptom Manage 2007;34(4):342-5.
184. Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical
studies on major depression and BDNF levels: implications for the role of neuroplasticity in
depression. Int J Neuropsychopharmacol 2008;11(8):1169-80.
185. Cecilio SB, Zaghi S, Cecilio LB, Correa CF, Fregni F. Exploring a novel therapeutic
approach with noninvasive cortical stimulation for vulvodynia. Am J Obstet Gynecol
2008;199(6):e6-7.
186. Cohen RB, Ferreira MS, Ferreora MJL, Fregni F. Use of repetitive transcranial magnetic
stimulation for the management of bipolar disorder during the postpartum period. Brain
Stimulation 2008;1(3):224-6.
187. Edwards D, Fregni F. Modulating the healthy and affected motor cortex with repetitive
transcranial magnetic stimulation in stroke: development of new strategies for neurorehabilitation.
NeuroRehabilitation 2008;23(1):3-14.
188. Jensen MP, Hakimian S, Sherlin LH, Fregni F. New insights into neuromodulatory
approaches for the treatment of pain. J Pain 2008;9(3):193-9.
189. Lima MC, Fregni F. Motor cortex stimulation for chronic pain: systematic review and
meta-analysis of the literature. Neurology 2008;70(24):2329-37.
190. Miniussi C, Cappa S, Cohen L, Floel A, Fregni F, Nitsche M, Oliveri M, Pascual-Leone
A, Paulus W, Priori A, Walsh V. Efficacy of repetitive transcranial magnetic stimulation/
transcranial direct current stimulation in cognitive neurorehabilitation. Brain Stimulation
2008;1:326-36.
191. Passos Mdo C, Duro D, Fregni F. CNS or classic drugs for the treatment of pain in
functional dyspepsia? A systematic review and meta-analysis of the literature. Pain Physician
2008;11(5):597-609.
192. Wu AD, Fregni F, Simon DK, Deblieck C, Pascual-Leone A. Noninvasive brain
stimulation for Parkinson's disease and dystonia. Neurotherapeutics 2008;5(2):345-61.
193. Zago S, Ferrucci R, Fregni F, Priori A. Bartholow, Sciamanna, Alberti: pioneers in the
electrical stimulation of the exposed human cerebral cortex. Neuroscientist 2008;14(5):521-8.
194. Boggio PS, de Macedo EC, Schwartzman JS, Brunoni D, Teixeira MC, Fregni F.
Transcranial direct current stimulation: a novel approach to control hyperphagia in Prader-Willi
syndrome. J Child Neurol 2009;24(5):642-3.
195. Boggio PS, Macedo EC, Pascual-Leone A, Munoz JMT, Schwartzman JS, Fregni F.
Neuromodulation in hypoxic-ischemic injury. Brain Stimulation 2009;2(3):179-81.
196. Bolognini N, Pascual-Leone A, Fregni F. Using non-invasive brain stimulation to
36
augment motor training-induced plasticity. J Neuroeng Rehabil 2009;6(8).
197. Brunoni A, Fragas R, Fregni F. Pharmacological and combined interventions for the acute
depressive episode: focus on efficacy and tolerability. Therapeutics and Clinical Risk Management
2009;5:897-910.
198. Brunoni A, Fregni F. Clinical Trial Design in Noninvasive Brain Stimulation Psychiatric
Research. Int J Methods Psychiatr Res. 2011 Jun;20(2):e19-30.
199. Brunoni AR, Correa C, Imamura M, Teng CT, Brazil-Neto JP, Boechat R, Rosa M,
Caramelli P, Choen R, Del Prto JA, Boggio PS, Fregni F. Neuromodulation approaches for the
treatment of major depression: challenges and recommendations from a working group meeting.
Arquivos de NeuroPsiquiatria 2010 Jun;68(3):433-51.
200. Brunoni AR, Fraguas R, Fregni F. Pharmacological and combined interventions for the
acute depressive episode: focus on efficacy and tolerability. Ther Clin Risk Manag 2009;5:897-
910.
201. Brunoni AR, Lopes M, Kaptchuk TJ, Fregni F. Placebo response of non-pharmacological
and pharmacological trials in major depression: a systematic review and meta-analysis. PLoS One
2009;4(3):e4824.
202. Williams JA, Imamura M, Fregni F. Updates on the use of non-invasive brain stimulation
in physical and rehabilitation medicine. J Rehabil Med 2009;41(5):305-11.
203. Freitas C, Fregni F, Pascual-Leone A. Meta-analysis of the effects of repetitive
transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia.
Schizophr Res 2009;108(1-3):11-24.
204. Hultgren B, Zaghi S, Carvas M, Nascimento B, Kwiakowski J, Fregni F. Challenges in
consenting subjects for studies with brain stimulation: feasibility of multimedia video use during
the informed consent process. Brain Stimulation 2009;2(3):174-8.
205. Murphy DN, Boggio P, Fregni F. Transcranial direct current stimulation as a therapeutic
tool for the treatment of major depression: insights from past and recent clinical studies. Curr Opin
Psychiatry 2009;22(3):306-11.
206. Nitsche MA, Boggio PS, Fregni F, Pascual-Leone A. Treatment of depression with
transcranial direct current stimulation (tDCS): a review. Exp Neurol 2009;219(1):14-9.
207. Williams JA, Colton K, Fregni F, Pascual-Leone A, Alexander MP. Feasibility of a home
constraint-induced movement therapy for hand weakness after stroke. J Rehabil Med
2009;41(1):92-3.
208. Zaghi S, Heine N, Fregni F. Brain stimulation for the treatment of pain: A review of costs,
clinical effects, and mechanisms of treatment for three different central neuromodulatory
approaches. Journal of Pain Management 2009;2(3):339-52.
209. Zaghi S, Acar M, Hultgren B, Boggio P, Fregni F. Noninvasive brain stimulation with
low-intensity electrical currents: putative mechanisms of action for direct and alternating current
stimulation. Neuroscientist 2010 Jun;16(3):285-307.
210. Jensen MP, Sherlin LH, Hakimian S, Fregni F. Neuromodulatory approaches for chronic
pain management: Research findings and clinical implications. Journal of Neurotherapy 2009;
13(4):196-213.
211. Zaghi S, DaSilva AF, Acar M, Lopes M, Fregni F. One-year rTMS treatment for
refractory trigeminal neuralgia. J Pain Symptom Manage 2009;38(4):e1-5.
212. Carvas M, Imamura M, Hsing W, Dewey-Platt L, Fregni F. An innovative method of
global clinical research training using collaborative learning with Web 2.0 tools. Med Teach.
2010;32(3):270.
213. Fregni F, Imamura M, Lew H, Boggio PS, Kaptchuk T, Chien HF, Riberto M, Hsing WT,
Battistella L, Furlan A. Challenges and recommendations for placebo controls in randomized trials
37
in Physical and Rehabilitation Medicine: a report of the international placebo symposium working
group. American Journal of Physical Medicine and Rehabilitation 2010 Feb;89(2):160-72.
214. Edelmuth RCL, Nitsche M, Battistella L, Fregni F. Why do some promising brain-
stimulation devices fail the next steps of clinical development? Expert Rev Med Devices
2010;7(1).
215. Brunoni AR, Tadini L, Fregni F. Changes in clinical trials methodology over time: a
systematic review of six decades of research in psychopharmacology. PLoS One 2010;
5(3):e9479.
216. Brunoni AR, Fregni F. Accelerating response to antidepressant treatment in depression: a
review and clinical suggestions. Prog Neuropsychopharmacol Biol Psychiatry 2010;34(2):437-8.
217. Fecteau S, Fregni F, Boggio PS, Camprodon JA, Pascual-Leone A. Neuromodulation of
decision-making in the addictive brain. Subst Use Misuse 2010;45(11):1766-86
218. Macea DD, Gajos K, Daglia Calil YA, Fregni F. The Efficacy of Web-Based Cognitive
Behavioral Interventions for Chronic Pain: A Systematic Review and Meta-Analysis. J Pain 2010,
Oct:11(10):917-29.
219. Brunoni AR, Valiengo L, Baccaro A, Zanao TA, de Oliveira JF, Vieira GP, Bueno VF,
Goulart AC, Boggio PS, Lotufo PA, Bensenor IM, Fregni F. Sertraline vs. Electrical Current
Therapy for Treating Depression Clinical Trial - SELECT TDCS: Design, rationale and
objectives. Contemp Clin Trials. 2011 Jan;32(1):90-8.
220. Fregni F. Analgesia with noninvasive electrical cortical stimulation: challenges to find
optimal parameters of stimulation. Anesth Analg. 2010 Nov;111(5):1083-5.
221. Horvath JC, Perez JM, Forrow L, Fregni F, Pascual-Leone A. Transcranial magnetic
stimulation: a historical evaluation and future prognosis of therapeutically relevant ethical
concerns. J Med Ethics. 2011 mar;37(3):137-43.
222. Lefaucheur JP, Antal A, Ahdab R, Ciampi de Andrade D, Fregni F, Khedr EM, Nitsche
M, Paulus W. The use of repetitive transcranial magnetic stimulation (rTMS) and transcranial
direct current stimulation (tDCS) to relieve pain. Brain Stimul. 2008 Oct;1(4):337-44.
223. Azeka E, Fregni F. Cardiovascular research: new model of collaborative training program.
Arq Bras Cardiol. 2010 Sep;95(3):281-2.
224. Brunoni AR, Valim C, Fregni F. Combination of noninvasive brain stimulation with
pharmacotherapy. Expert Rev Med Devices. 2011 Jan;8(1):31-9. Review.
225. Abdul Latif L, Daud Amadera JE, Pimentel D, Pimentel T, Fregni F. Sample size
calculation in physical medicine and rehabilitation: a systematic review of reporting,
characteristics, and results in randomized controlled trials. Arch Phys Med Rehabil. 2011
Feb;92(2):306-15. Review.
226. Bashir S, Mizrahi I, Weaver K, Fregni F, Pascual-Leone A. Assessment and modulation
of neural plasticity in rehabilitation with transcranial magnetic stimulation. PM R. 2010 Dec;2(12
Suppl 2):S253-68. Review.
227. Oliveira L, Fregni F. Pharmacological and electrical stimulation in chronic disorders of
consciousness: New insights and future directions. Brain Inj. 2011;25(4):315-27.
228. Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F. A systematic review
on reporting and assessment of adverse effects associated with transcranial direct current
stimulation. Int J Neuropsychopharmacol. 2011 Feb 15:1-13.
229. Demange MK, Fregni F. Limits to clinical trials in surgical areas. Clinics (Sao Paulo).
2011;66(1):159-61.
230. Brunoni AR, Valiengo L, Zanao T, de Oliveira JF, Bensenor IM, Fregni F. Manic
psychosis after sertraline and transcranial direct-current stimulation. J Neuropsychiatry Clin
Neurosci. 2011 Summer;23(3):E4-5.
38
231. Boggio PS, Valasek CA, Campanhã C, Giglio AC, Baptista NI, Lapenta OM, Fregni F.
Non-invasive brain stimulation to assess and modulate neuroplasticity in Alzheimer's disease.
Neuropsychol Rehabil. 2011 Oct;21(5):703-16.
232. Brunoni AR, Fregni F, Pagano RL. Translational research in transcranial direct current
stimulation (tDCS): a systematic review of studies in animals. Rev Neurosci. 2011;22(4):471-81.
Review.
233. Azeka E, Fregni F, Auler Junior JO. The past, present and future of clinical research.
Clinics (Sao Paulo). 2011;66(6):931-2.
234. DaSilva AF, Volz MS, Bikson M, Fregni F. Electrode positioning and montage in
transcranial direct current stimulation. J Vis Exp. 2011 May 23;(51).
235. Brunoni AR, Fregni F. Clinical trial design in non-invasive brain stimulation psychiatric
research. Int J Methods Psychiatr Res. 2011 Jun;20(2):e19-30. doi: 10.1002/mpr.338. Review.
236. Wilson ME, Fregni F, de S M Veras MA, Dyett J, Shei A, Ribeiro GS, David J, Castro
MC, Segurado AC, Ko AI, Reis MG. Collaborative teaching and learning: a model for building
capacity and partnerships to address NTDs. PLoS Negl Trop Dis. 2011 Mar 29;5(3):e939. Erratum
in: PLoS Negl Trop Dis. 2011 Aug;5(8). doi: 10.1371/annotation/d33a8e45-4a41-49c7-81b1-
1355a4c28a81. Fregni, Felipe [added]; de S M Veras, Maria Amelia [added]; Dyett, Jason
[added]; Shei, Amie [added];Ribeiro, Guilherme Sousa [added]; David, John [added]; Castro,
Marcia C [added];Segurado, Aluisio Cotrim [added].
237. Adeyemo BO, Simis M, Macea DD, Fregni F. Systematic review of parameters of
stimulation, clinical trial design characteristics, and motor outcomes in non-invasive brain
stimulation in stroke. Front Psychiatry. 2012;3:88.
238. Medeiros LF, de Souza IC, Vidor LP, de Souza A, Deitos A, Volz MS, Fregni F, Caumo
W, Torres IL. Neurobiological effects of transcranial direct current stimulation: a review. Front
Psychiatry. 2012;3:110.
239. Volz MS, Volz TS, Brunoni AR, de Oliveira JP, Fregni F. Analgesic effects of
noninvasive brain stimulation in rodent animal models: a systematic review of translational
findings. Neuromodulation. 2012 Jul;15(4):283-95.
240. Bikson M, Rahman A, Datta A, Fregni F, Merabet L. High-resolution modeling assisted
design of customized and individualized transcranial direct current stimulation protocols.
Neuromodulation. 2012 Jul;15(4):306-15.
241. Fregni F, Merabet LB. Bench to clinical translational applications of noninvasive brain
stimulation. Neuromodulation. 2012 Jul;15(4):281-2.
242. Villamar MF, Santos Portilla A, Fregni F, Zafonte R. Noninvasive brain stimulation to
modulate neuroplasticity in traumatic brain injury. Neuromodulation. 2012 Jul;15(4):326-38.
243. Brunoni AR, Nitsche MA, Bolognini N, Bikson M, Wagner T, Merabet L, Edwards DJ,
Valero-Cabre A, Rotenberg A, Pascual-Leone A, Ferrucci R, Priori A, Boggio PS, Fregni F.
Clinical research with transcranial direct current stimulation (tDCS): challenges and future
directions. Brain Stimul. 2012 Jul;5(3):175-95.
244. Brunoni AR, Ferrucci R, Fregni F, Boggio PS, Priori A. Transcranial direct current
stimulation for the treatment of major depressive disorder: a summary of preclinical, clinical and
translational findings. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):9-16.
245. Shiozawa P, da Silva ME, Raza R, Uchida RR, Cordeiro Q, Fregni F, Brunoni AR. Safety
of Repeated Transcranial Direct Current Stimulation in Impaired Skin: A Case Report. J ECT.
2013 Jan 8. [In press]
246. Brunoni AR, Boggio PS, Ferrucci R, Priori A, Fregni F. Transcranial direct current
stimulation: challenges, opportunities, and impact on psychiatry and neurorehabilitation. Front
Psychiatry. 2013;4:19.
39
247. Shiozawa P, da Silva ME, Cordeiro Q, Fregni F, Brunoni AR. Transcranial Direct Current
Stimulation (tDCS) for the Treatment of Persistent Visual and Auditory Hallucinations in
Schizophrenia: A Case Study. Brain Stimul. 2013 Apr 2. [In press]
248. Brunoni AR, Kemp AH, Shiozawa P, Cordeiro Q, Valiengo LC, Goulart AC, Coprerski B,
Lotufo PA, Brunoni D, Perez AB, Fregni F, Benseñor IM. Impact of 5-HTTLPR and BDNF
polymorphisms on response to sertraline versus transcranial direct current stimulation:
Implications for the serotonergic system. Eur Neuropsychopharmacol. 2013 Apr 21. [In press]
249. Shiozawa P, da Silva ME, Cordeiro Q, Fregni F, Brunoni AR. Transcranial direct current
stimulation (tDCS) for catatonic schizophrenia: a case study. Schizophr Res. 2013 May;146(1-
3):374-5.
250. Cano T, Morales-Quezada JL, Bikson M, Fregni F. Methods to focalize noninvasive
electrical brain stimulation: principles and future clinical development for the treatment of pain.
Expert Rev Neurother. 2013 May;13(5):465-7.
251. Andrade DC, Borges I, Bravo GL, Bolognini N, Fregni F. Therapeutic time window of
noninvasive brain stimulation for pain treatment: inhibition of maladaptive plasticity with early
intervention. Expert Rev Med Devices. 2013 May;10(3):339-52.
252. Schestatsky P, Simis M, Freeman R, Pascual-Leone A, Fregni F. Non-invasive brain
stimulation and the autonomic nervous system. Clin Neurophysiol. 2013 May 16. [In press]
253. Villamar MF, Contreras VS, Kuntz RE, Fregni F. The reporting of blinding in physical
medicine and rehabilitation randomized controlled trials: A systematic review. J Rehabil Med.
2013 May 21;45(1):6-13.
254. Shiozawa P, da Silva ME, Raza R, Uchida RR, Cordeiro Q, Fregni F, Brunoni AR. Safety
of repeated transcranial direct current stimulation in impaired skin: a case report. J ECT. 2013
Jun;29(2):147-8.
255. Moreno-Duarte I, Morse LR, Alam M, Bikson M, Zafonte R, Fregni F. Targeted
therapies using electrical and magnetic neural stimulation for the treatment of
chronic pain in spinal cord injury. Neuroimage. 2014 Jan 15;85 Pt 3:1003-13. doi:
10.1016/j.neuroimage.2013.05.097. Epub 2013 May 30. PubMed PMID: 23727533.
256. Fidalgo TM, Morales-Quezada JL, Muzy GS, Chiavetta NM, Mendonca ME, Santana
MV, Goncalves OF, Brunoni AR, Fregni F. Biological Markers in Noninvasive Brain
Stimulation Trials in Major Depressive Disorder: A Systematic Review. J ECT. 2013
Jul 10. [Epub ahead of print] PubMed PMID: 23845938.
257. Simis M, Bravo GL, Boggio PS, Devido M, Gagliardi RJ, Fregni F. Transcranial
Direct Current Stimulation in de novo Artistic Ability After Stroke.
Neuromodulation. 2013 Dec 9. doi: 10.1111/ner.12140. [Epub ahead of print] PubMed
PMID: 24320745.
258. Shiozawa P, Cordeiro Q, Fregni F, Brunoni AR. Is sertraline plus transcranial
direct current stimulation the future of effective depression treatment? J Comp
Eff Res. 2013 May;2(3):213-5. doi: 10.2217/cer.13.28. PubMed PMID: 24236617.
259. Grecco LA, Duarte Nde A, de Mendonça ME, Pasini H, Lima VL, Franco RC, de
Oliveira LV, de Carvalho Pde T, Corrêa JC, Collange NZ, Sampaio LM, Galli M,
Fregni F, Oliveira CS. Effect of transcranial direct current stimulation combined
with gait and mobility training on functionality in children with cerebral palsy:
study protocol for a double-blind randomized controlled clinical trial. BMC
Pediatr. 2013 Oct 11;13:168. doi: 10.1186/1471-2431-13-168. PubMed PMID:
24112817; PubMed Central PMCID: PMC3852945.
260. Andrade AC, Magnavita GM, Allegro JV, Neto CE, Lucena RD, Fregni F.
Feasibility of Transcranial Direct Current Stimulation Use in Children Aged 5 to
40
12 Years. J Child Neurol. 2013 Sep 18. [Epub ahead of print] PubMed PMID:
24049057.
261. Shiozawa P, Leiva AP, Castro CD, da Silva ME, Cordeiro Q, Fregni F, Brunoni
AR. Transcranial Direct Current Stimulation for Generalized Anxiety Disorder: A
Case Study. Biol Psychiatry. 2013 Aug 16. pii: S0006-3223(13)00643-4. doi:
10.1016/j.biopsych.2013.07.014. [Epub ahead of print] PubMed PMID: 23958182.
262. Guleyupoglu B, Schestatsky P, Edwards D, Fregni F, Bikson M. Classification
of methods in transcranial electrical stimulation (tES) and evolving strategy
from historical approaches to contemporary innovations. J Neurosci Methods. 2013
Oct 15;219(2):297-311. doi: 10.1016/j.jneumeth.2013.07.016. Epub 2013 Aug 14.
PubMed PMID: 23954780; PubMed Central PMCID: PMC3833074.
263. Bolognini N, Spandri V, Olgiati E, Fregni F, Ferraro F, Maravita A. Long-term
analgesic effects of transcranial direct current stimulation of the motor cortex
on phantom limb and stump pain: a case report. J Pain Symptom Manage. 2013
Oct;46(4):e1-4. doi: 10.1016/j.jpainsymman.2013.06.014. Epub 2013 Aug 7. PubMed
PMID: 23932177.
264. Villamar MF, Volz MS, Bikson M, Datta A, Dasilva AF, Fregni F. Technique and
considerations in the use of 4x1 ring high-definition transcranial direct current
stimulation (HD-tDCS). J Vis Exp. 2013 Jul 14;(77):e50309. doi: 10.3791/50309.
PubMed PMID: 23893039; PubMed Central PMCID: PMC3735368.
265. Schestatsky P, Morales-Quezada L, Fregni F. Simultaneous EEG monitoring
during transcranial direct current stimulation. J Vis Exp. 2013 Jun 17;(76). doi: 10.3791/50426.
PubMed PMID: 23851401; PubMed Central PMCID: PMC3727533.
Non-peer reviewed scientific or medical publications/materials in print or other media
Proceedings of meetings or other non-peer reviewed research publications
1. Fregni F, Thome-Souza S, Bermpohl F, Marcolin MA, Herzog A, Pascual-Leone A,
Valente KD. Antiepileptic effects of repetitive transcranial magnetic stimulation in patients with
cortical malformations: an EEG and clinical study. Stereotact Funct Neurosurg 2005;83(2-3):57-
62.
2. Gonçalves ÓF, Carvalho S, Leite J, Pocinho F, Relvas J, Fregni F. Obsessive Compulsive
Disorder as a functional interhemispheric imbalance at the thalamic level. Med Hypotheses.
2011 Sep;77(3):445-7.
Reviews, chapters, monographs and editorials 3. Fregni F, Pascual-Leone A. Transcranial magnetic stimulation: a new tool in the
treatment of depression? . Rev Psiq Clin 2001;28(5):253-65.
4. Fregni F, Pascual-Leone A. Repetitive transcranial magnetic stimulation to treat
Parkinson Disease. Journal Watch Neurology 2003;5(10):73-4.
5. Fregni F, MA. M. Clinical applications of Transcranial Magnetic Stimulation in
Neuropsychiatric disorders: Transcranial Magnetic Stimulation in the Clinical Practice. Rev Psiq
Clin 2004;31(5):216-20.
6. Fregni F, Pascual-Leone A, Valente K. A therapeutic window for transcranial magnetic
stimulation in refractory epilepsy. J Epilepsy Clin Neurophysiol 2005;11(4):177-81.
7. Pascual-Leone A, Amedi A, Fregni F, Merabet LB. The plastic human brain cortex. Annu
Rev Neurosci 2005;28:377-401.
41
8. Fregni F, Lima M, Riberto M, Batistella L, Boggio P. Brain Stimulation for the
Neuropathic Pain Treatment. Revista Psicologia Teoria e Pratica 2007;9(2):142-9.
9. Imamura M, Imamura ST, Fregni F. Sindrome Dolorosa Miofascial
10. Papel da medicina fisica no tratamento reumatologico. In: Lopes AC, ed. Tratado de
clinica medica. Sao Paulo: Editora Roca; 2007.
11. Padberg F, Grossheinrich N, Pogarell O, Moller H, Fregni F. Efficacy and Saftey of
Prefrontal Repetitive Transcranial Magnetic Stimulation in Affective Disorders. In: Padberg F,
Marcolin M, eds. Transcranial Brain Stimulation for Treatment of Psychiatric Disorders. Basel:
Karger AG; 2007:53-83.
12. Brunoni AR, Boggio PS, Fregni F. Can the 'yin and yang' BDNF hypothesis be used to
predict the effects of rTMS treatment in neuropsychiatry? Med Hypotheses 2008;71(2):279-82.
13. Fregni F. Towards novel treatments for pediatric stroke: is transcranial magnetic
stimulation beneficial? Lancet Neurol 2008;7(6):472-3.
14. Fregni F, Thut G, Rotenberg A, Pascual-Leone A. Successful transcranial magnetic
stimulation in a patient with medically intractable focal epilepsy. In: Luders HO, ed. Textbook
of Epilepsy Surgery. London: Informa Healthcare, Telephone House; 2008:1511-7.
15. Hummel F, Celnik P, Pascual-Leone A, Fregni F, Byblow D, Buetefisch C, Rothwell J,
Cohen L, Gerloff C. Controversy: Noninvasive and invasive cortical stimulation show efficacy
in treating stroke patients. Brain Stimulation 2008;1(4):370-82.
16. Langguth B, Ridder D, Dornhoffer J, Eichhammer P, Folmer R, Frank E, Fregni F,
Gerloff C, Khedr E, Kleinjung T, Landgrebe M, Lee S, Lefaucheur J, Londero A, Marcondes R,
Moller A, Pascual-Leone A, Plewnia C, Rossi S, Sanchez T, Sand P, Schlee W, Steffens T,
Heyning P, Hajak G. Controversy: Does repetitive transcranial magnetic stimulation/
transcranial direct current stimulation show efficacy in treating tinnitus patients? Brain
Stimulation 2008;1(3).
17. Nitsche MA, Cohen LG, Wassermann EM, Priori A, Lang N, Antal A, Paulus W,
Hummel F, Boggio PS, Fregni F, Pascual-Leone A. Transcranial direct current stimulation:
State of the art 2008. Brain Stimulation 2008;1(3):206-23.
18. Zanardi R, Barbini B, Rossini D, Bernasconi A, Fregni F, Padberg F, Rossi S, Wirz-
Justice A, Terman M, Martiny K, Bersani G, Hariri AR, Pezawas L, Roiser JP, Bertolino A,
Calabrese G, Magri L, Benedetti F, Pontiggia A, Malaguti A, Smeraldi E, Colombo C. New
perspectives on techniques for the clinical psychiatrist: Brain stimulation, chronobiology and
psychiatric brain imaging. Psychiatry Clin Neurosci 2008;62(6):627-37.
19. Boggio PS, Carreiro LR, Fregni F. Cortical stimulation with weak electrical currents for
cognitive modulation in attention deficit hyperactivity disorder. Med Hypotheses
2009;72(5):613-4.
20. Cogiamanian F, Brunoni AR, Boggio PS, Fregni F, Ciocca M, Priori A. Non-invasive
brain stimulation for the management of arterial hypertension. Med Hypotheses 2010
Feb;74(2):332-6.
21. Imamura M, Cassius DA, Fregni F. Fibromyalgia: From treatment to rehabilitation.
European Journal of Pain Supplements 2009 Nov 1;3(2):117-122.
22. Imamura M, Hsing WT, Platt LD, Fregni F. How to develop research capacity using a
collaborative training approach: the International Society of Physical and Rehabilitation
Medicine (ISPRM) international training program experience. J Rehabil Med 2009;41(4):295-6.
23. Williams JA, Fregni F. Transcranial direct current stimulation. In: Swartz CM, ed.
Electroconvulsive and Neuromodulation Therapies. Cambridge: Cambridge Press; 2009:573-82.
24. Williams JA, Rotenberg A, Fregni F. Transcranial Magnetic Stimulation (rTMS) as a
Therapeutic Tool for Epilepsy. In: Mally J, ed. The Repetitive Transcranial Magnetic Simulation
42
in the Treatment and Rehabilitation of Central Nervous Diseases. Budapest: Eurobidge Co.;
2009:123-30.
25. Simis M, Fregni F. Transcranial Magnetic Stimulation and Neuromodulation. In: Cukiert
A. (ed.), Neuromodulation (1st edition), São Paulo: Alaúde Editorial, 2010.
26. Reidler J.S., Zaghi S., Fregni F. Neurophysiological Effects of Transcranial Direct
Current Stimulation, In Coben R., and Evans J. (eds). Neurofeedback of Neuromodulation
Technique and Applications, 2011: 319-44, Elselvier.
27. Azeka E, Fregni F. Cardiovascular research: new model of collaborative training
program. Arq Bras Cardiol. 2010 Sep;95(3):281-2.
28. Han SJ, Imamura M, Fregni, F. Non-pharmacological placebo controlled randomized
trials and the role of pragmatic trials in PRM. In: Franchignoni, F. (ed.), Research issues in
Physical& Rehabilitation Medicine, Maugeri Foundation Books (Vol. 19), Pavia, Italy, 2010
29. Iasemidis LD, Schachter S, Fregni F, Ilmoniemi R. Introduction. Int J Neural Syst. 2013
Feb;23(1):1203003.
Letters to the Editor 30. Fregni F, O'Connor M, Pascual-Leone A. ECT and rTMS for depression. Br J Psychiatry
2005;187:386.
31. Fregni F, Pascual-Leone A. Repetitive transcranial magnetic stimulation for the treatment
of depression. J Psychiatry Neurosci 2005;30(6):434.
32. Fregni F, Kaptchuk TJ, Imamura M, Chien HF, Riberto M, Hsing WT, Battistella LR,
Lew HL, Boggio P, Furlan A. Re: challenges and recommendations for placebo controls in
randomized trials in physical and rehabilitation medicine: a report of the international placebo
symposium working group. Am J Phys Med Rehabil. 2010 Dec;89(12):1046-7.
33. Villamar MF, Fregni F. Response to the letter to the editor by Berger. J Rehabil Med.
2013 Feb;45(2):221-2.
34. Imamura M, Özçakar L, Fregni F, Hsing WT, Battistella LR. Exploring a long-term
global approach for musculoskeletal ultrasound training: WORLD-MUSCULUS. J Rehabil
Med. 2012 Nov 5;44(11):991-2.
Publications without named authorship (working group articles) 35. Rossi S, Hallett M, Rossini PM, Pascual-Leone A. Safety, ethical considerations, and
application guidelines for the use of transcranial magnetic stimulation in clinical practice and
research. Clin Neurophysiol 2009;120(12):2008-39.
36. Schachter SC, Guttag J, Schiff SJ, Schomer DL. Advances in the application of
technology to epilepsy: the CIMIT/NIO Epilepsy Innovation Summit. Epilepsy Behav
2009;16(1):3-46.
Clinical Guidelines and Reports
1. Syllabus for the Course: Field Trip to Brazil PIH 542 (HSPH)
Published at http://www.hsph.harvard.edu/registrar/courses/wintersession/all.shtml
Audience: Graduate Students from HSPH
I was a co-founder and instructor of this course (now led by Dr. Mary Wilson only)
2. Syllabus for the HMS CME course: Principles and Practice of Clinical Research
Published at http://www.clinicalresearchlearning.org
Audience: Physicians and Clinical Researchers
43
I am the course director
3. 22 Teaching cases (cases of an average of 8 pages each case) for the HMS CME course Principles
and Practice of Clinical Research
Published at http://www.clinicalresearchlearning.org
Audience: Physicians and Clinical Researchers
Role: Author of these cases
Thesis
1. Fregni F. Comparison of rapid-rate transcranial magnetic stimulation and fluoxetine in
patients with Parkinson’s disease and depression: a randomized trial (PhD thesis). Sao Paulo,
Brazil: University of Sao Paulo;2004.
2. Fregni F. Clinical Applications of Noninvasive Brain Stimulation in Neurology (MMSs
thesis). Boston, MA: Harvard Medical School;2006.
3. Fregni F. Use of a non-expensive method of noninvasive brain stimulation for the
treatment of fibromyalgia (MPH thesis). Boston, MA: Harvard School of Public Health;2007.
Narrative Report (limit to 500 words)
The focus of my research has largely been centered upon developing methods of neuromodulation as
potential treatment tools as well investigating their mechanisms and impact on brain plasticity. The
majority of my effort is dedicated to research, teaching, mentoring and administrative activities to run my
laboratory.
I have conducted several clinical trials and also mechanistic studies investigating the effects of
noninvasive neuromodulatory tools in neuropsychiatry. Some of these studies are highly cited studies and
have a significant impact on the field of neuromodulation such as my work in Parkinson’s disease in
which we investigated the impact of neuromodulation on motor function, mood and cognition; also
assessing the neural correlates using neuroimaging (SPECT). Another important area is my work in
chronic pain. We were the first to publish a trial investigating the impact of transcranial direct current
stimulation for chronic pain in spinal cord injury. This study received an award as the top 10 most cited
paper in the period of 2006-2008 in the journal PAIN (the highest impact in the field of pain). In addition,
this and my other studies in this field have led to successful grant applications (two NIH R21 grants).
Along the same lines, some of my studies in stroke using methods of neuromodulation resulted also in
important contributions to the field, as other research laboratories are now interested and conducting
research in this area, using the approach I developed of balancing bi-hemispheric activity with brain
stimulation.
I have also been conducting studies using animal models in collaboration with other laboratories. We have
been exploring the effects of rTMS, repetitive electrical stimulation and tDCS on the brain, measuring
several outcomes including invasive EEG recordings, cortical spreading depression and assessment of
LTD/LTP in animal slices.
Besides my research efforts, I have been actively involved in teaching. I have focused my efforts in two
major areas: Neuromodulation and clinical research methodology. In Neuromodulation, I have organized
and chaired 4 international symposiums. The most recent was a large International Symposium, in which
10 renowned speakers and faculty members from Europe and US met in Sao Paulo, Brazil for a 4-day
44
meeting (there was 400 participants in this symposium). Also, in the area of clinical research
methodology, I have created a 6-month distance and collaborative learning course in clinical research
with several colleagues. This is a large international HMS course (with an average of 120 students). The
goal is to train clinical researchers across the world. We developed a highly interactive and collaborative
learning method (it can be seen in www.clinicalresearchlearning.org) including also the case teaching
method.
In conclusion, this report can be summarized by the mission of the laboratory I direct (Laboratory of
Neuromodulation & Clinical Research Learning Center) that is to investigate the main techniques of
neuromodulation including their mechanisms of action in neurology and rehabilitation. In addition my
laboratory is an active center for training in neuromodulation and clinical research, offering several
training programs. The ultimate goal is to develop novel clinical tools using noninvasive brain
stimulation.