fasting hdl (mg/dl) fasting ldl (mg/dl) fasting tg (mg/dl)

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Fasting HDL (mg/dL) Fasting LDL (mg/dL) Fasting TG (mg/dL) Study N WMD (95% CI) WMD (95% CI) WMD (95% CI) Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144 Favors Metformin p=0.21 Favors Metformin p<0.001 Favors Metformin p=0.11 Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144 -1.02 (-3.99, 1.94) Favors Rosiglitazone p=0.50 Fasting Insulin (mU/L) Fasting Glucose (mg/dL) Study N WMD (95% CI) WMD (95% CI) 0.80 (0.47, 1.14) 0.03 (0.01, 0.05) Favors Metformin p<0.001 Favors Metformin p=0.01 Favors Metformin p=0.39 Body Mass Index (kg/m2) Waist to Hip Ratio Visceral Abdominal Fat (cm2) Study N WMD (95% CI) WMD (95% CI) WMD (95% CI) Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144 9.88 (-12.55, 32.32), * Favors Metformin p=0.55 eighted mean difference (based on change from baseline for each group), calculated using random effects models t for heterogeneity p=0.06; ***only two studies so source of heterogeneity could not be determined 1.09 (-2.48, 4.65) -6.94 (-9.50, - 4.37) 7.38 (-4.17, 18.93) 45.05 (-10.50, 100.6)

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Fasting Insulin (mU/L)Fasting Glucose (mg/dL) Study N WMD (95% CI) WMD (95% CI). Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144. -1.02 (-3.99, 1.94). 1.09 (-2.48, 4.65). - PowerPoint PPT Presentation

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Page 1: Fasting HDL (mg/dL) Fasting LDL (mg/dL) Fasting TG (mg/dL)

Fasting HDL (mg/dL) Fasting LDL (mg/dL) Fasting TG (mg/dL)

Study N WMD (95% CI) WMD (95% CI) WMD (95% CI)

Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144

Favors Metforminp=0.21

Favors Metforminp<0.001

Favors Metforminp=0.11

Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144

-1.02 (-3.99, 1.94)Favors Rosiglitazone

p=0.50

Fasting Insulin (mU/L) Fasting Glucose (mg/dL)

Study N WMD (95% CI) WMD (95% CI)

0.80 (0.47, 1.14) 0.03 (0.01, 0.05)Favors Metformin

p<0.001Favors Metformin

p=0.01Favors Metformin

p=0.39

Body Mass Index (kg/m2) Waist to Hip Ratio Visceral Abdominal Fat (cm2)Study N WMD (95% CI) WMD (95% CI) WMD (95% CI)

Rosiglitazone vs. Metformin Mulligan 53 van Wijk/Coll 31 Tomazic 60 Overall 144

9.88 (-12.55, 32.32), *

Favors Metforminp=0.55

WMD=weighted mean difference (based on change from baseline for each group), calculated using random effects models

* Test for heterogeneity p=0.06; ***only two studies so source of heterogeneity could not be determined

1.09 (-2.48, 4.65)

-6.94 (-9.50, -4.37) 7.38 (-4.17, 18.93) 45.05 (-10.50, 100.6)

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