Presented by :

ANTOINETTE RHEMA LOUIS (III – BDS)

HERTWIG’S EPITHELIAL ROOT SHEATH

FORMATION

SCHEMATIC DIAGRAM :

F :

EPITHELIAL

CELL RESTS

OF MALASSEZ

EPITHELIAL CELL RESTS OF MALASSEZ

LOCATION

FUNCTIONS :

Cementoblast

differentiation

Periodontal

homeostasis and

regeneration

Protection against

root resorption

Maintains periodontal

space

KNOWN FACT :

INFLAMMATORY

CYTOKINES ARE

RESPONSIBLE

FOR RADICULAR

CYST

AIM OF MY PRESENTATION :

ON NET SEARCH :

SOME INTERESTING

FACTS ON EPITHELIAL

CELL RESTS OF

MALASSEZ :

PERIODONTAL

HOMEOSTASIS –

REGENERATION

AND REPAIR

CEMENTAL REPAIR

Noggins

Bone morphogenicprotein.

EXPRESSION OF CK8, OPG, OPN GENES

STEM CELL

SUBPOPULATION

Epithelial –

mesenchymal

interaction

ON ELECTRON

MICROSCOPY :

IN RESTING STATE :

IN ACTIVE STATE :

In resting state :

In active state :

EXPRESSION

OF MARKERS :

HSP

VEGF

OPN

Mechanical stress

ALTERED Gli2

EXPRESSION

PTCH -1

GENE

MUTATION

XRCC – 1

POLY

- MORPHISM

predicts

Ameloblastom

a

N - METHYL N -

NITROSOUREA

INDUCES

AMELOBLASTOMA

BUT THE QUESTION

IS YET

UNANSWERED…????

??