ezetimibe - cvgkacc 2015 . improve-it: externe validiteit ... alter the splicing process at sites of...
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Ezetimibe:
• Ook hiermee reductie van events van een niet-statine middels LDL daling
• Improve-It • Ook ondersteuning door Mendelian Randomization
studies
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NEJM 2015
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NEJM 2006
LDL 100 mg/dl = 2.5 mmol/l
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ACC 2015
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Improve-It: externe validiteit
• Middel is effectief en veilig …. • Enge interpretatie: alleen tbv streven naar zeer lage
LDL waarden post ACS.. • Ruime interpretatie: te gebruiken naast max
getolereerde statine therapie bij streven naar voldoende LDL daling cq streven naar LDL doelwaarde ..
• Immers: rosuva ook te gebruiken buiten prim preventie populatie met licht verhoogd CRP ….
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Dus visie tav ezetimibe:
• Genetisch gevalideerd • Externe validiteit • Ook incorporatie in toekomstige adviezen tav PCSK9
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Nb: LDL daling .. het hoe is ook van belang !!
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PCSK9:
• Alles wijst op een succesvolle uitkomst van de studies • Genetisch gevalideerd • Safety zal zelden in een RCT goed tot uiting komen • Primair inzetten bij patiënten met een zeer hoog
residueel risico (maar denk tegelijkertijd aan andere medicatie .. langer geven van DAPT etc)..
• Game-changer: vergelijkbaar met introductie van NOACs bij AF
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