extern interesting case group 3 7 june 2007. history case 5 months-old boy chief complaint : dyspnea...
TRANSCRIPT
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Extern Interesting Case
Group 3
7 June 2007
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History
Case 5 months-old boyChief complaint :
Dyspnea during breastfeeding 2 months PTA
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Present history
2 months PTA, his mother noticed that
her child had dyspnea during breastfeeding.
He took time about 2-3 minutes each feeding
and rested 30 minutes before continue
next feeding.
At the appointment for vaccination,
He was detected that his weight didn’t gain well.
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Present history (cont’)
3 wk PTA, He had fever, productive
cough with progressive dyspnea. He
was brought to a private hospital.
Physical examination shown coarse
crepitation both lung, pansystolic murmur
grade III/VI at left parasternal border and liver
was palpated 1 cm. below right costal margin
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Present history (cont’)
He was diagnosed pneumonia with
congestive heart failure and was admitted.
Cefotaxime 150 mg IV q 8 hr and Digoxin
0.4 ml oral bid was given for eight days.
After pneumonia resolved, he was referred
to Siriraj hospital.
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Other history
Developmental history :Rolling , Palmar grasp, Turn to voice and bubbling.
Food history : Breast feeding , infant formula and supplementary foods.
Drug and Vaccination : Last vaccination at 4 month-old. No drug allergy
Delivery history :Normal labour , term AGA BW 3150 Apgar 9,9
Family history : No congenital heart disease , genetic disease in family
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Physical examination
V/S : T. 36.7C, RR 80/min , PR 177/min
BP 71/53 75/47 O2 sat 99 98 90/40 80/53 99 98
BW 4.4 kg (<p3)
Lt. 61 cm (p25) HC 40 cm (p25)
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Growth Chart
Weight < p3
Length p25
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Physical examination
GA : Alert ,mildly pale ,no jaundice, tachypnea, marked dyspnea (suprasternal, substernal
and subcostal retraction), no central and peripheral cyanosis, no clubbing of finger,
no paradoxical of chest movement, no dysmorphic feature
HEENT : pharynx and tonsils not injected , no thyroid enlargement
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Physical examination
RS : Pectus carinatum, normal breath sound,
no adventitious sound
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Physical examination
CVS : PMI at 5th Intercostal space just lateral to midclavicular line, Apical heaving. Loud P2
No bounding pulse
- Pansystolic murmur gr III/VI at Left lower sternal border
- Diastolic rumbling murmur gr II at apex
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Physical examination
Abdomen : soft, not tender, liver 2 cm Below right costal margin , smooth surface rubbery consistency. spleen not palpable
NS : active, symmetrical movement,
normal muscle tone, good motor power
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Problem list
1. Dyspnea during breastfeeding for 2 months
2. Poor weight gain
3. Tachypnea , tachycardia , hepatomegaly
and cardiomegaly
4. Heart murmurs
5. History of pneumonia
6. Mildly pale
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Approach to dyspnea
Cardiology cause Respiratory cause Metabolic cause Neurologic cause
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Congestive heart failure
Cardinal signs
1. Tachycardia
2. Tachypnea
3. Cardiomegaly Pectus carinatum
4. Hepatomegaly History of dyspnea on lactation
( feeding difficulties > 20 min ) Poor weight gain failure to thrive
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Investigation
Complete blood count
Hb 9.1 g/dl Hct 31.1 % MCV 58.2 fl
RDW 18.3%
Wbc 12,020 /mm3 ( N 32 % L 59 % )
Platelet 523,000 /mm3 Peripheral blood smear
Hypochromic microcytic anemia
no anisopoikilocytosis
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Investigation
Blood chemistrry
BUN 11 , Cr 0.2 , Na 139 ,K 3.8, Cl 104 ,
HCO3 22
Ca 9.4, Mg 2.1, PO4 57
VBG ( on oxygen 1 LPM )
pH 7.363 pCO2 43.80 pO2 72.5 HCO3 25.1
O2sat 93.7
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Investigation
CT ratio = 0.65 Increase pulmonary
vasculature
CXR Portable
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EKG Left atrial enlargementLeft ventricular hypertrophy
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Etiology of Heart disease
Congenital heart disease Acquired heart disease
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Approach to congenital heart disease
CHD
Acyanosis Cyanosis
PBF
L/BVH RVH
PBF
BVH LVH RVH
PBF
LVH RVH
PBF
L/BVH RVH
-Large VSD-PDA-ECD
-ASD (often RBBB)-PAPVR
-AS-AR-CoA-MR
-PS-CoA-MS
-Truncus arteriosus-Common ventricle-TGA+VSD
-TGA-TAPVR-HLHS
-TGA + PS-Common ventricle c PS
-TA-PA cHypoplasia RV
-TOF-Ebstein anomaly-PVOD 2 to VSD, PDA
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Approach to congenital heart disease
CHD
Acyanosis Cyanosis
PBF
L/BVH
-Large VSD-PDA-ECD
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Approach to acyanotic heart disease
CHD
Acyanosis
PBF
L/CVH
PBF
L/BVH
-Large VSD-PDA-ECD
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Echocardiogram
Gold standard for diagnosis Moderate perimembranous extended to
inlet VSD 8 mm , left to right shunt , no PDA no coarctation of aorta
EF 70 %
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Large ventricular septal defect
Pansystolic murmur grade III at LLSB
Diastolic rumbling murmur grade II at apex
( Relative mitral stenosis )
Loud P2
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Definite diagnosis
Congestive heart failure with moderate ventricular septal defect with failure to thrive
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Ventricular septal defect
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Type of VSD
Type I ( outlet or
subpulmonary or
subarterial type) Type II (membranous
type) Type III (inlet type) Type IV (muscular type)
I Subpulmonary
II membranous
III inlet
IV Muscular
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Sign and symptoms
Size of VSD Symptom Sign
Small asymptomatic pansystolic murmur at LLSB
Moderate Dyspnea on exertion
CHF (about age 6-8th weeks), loud P2 , Pansytolic murmur at
Large dyspnea at rest LLSB and mild diastolic rumbing murmur at apex (relative MS)
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Clinical course
Small defects, close spontaneously
(during the first 2 years) esp Type II and IV The vast majority of defects, close before
aged 4 years (may be in adults) Moderate or Large VSD : mostly remain
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Complication
Pulmonary vascular obstruction disease or Eisenmenger syndrome
VSD c PS Recurrent pneumonia Infective endocarditis Aortic regurgitation esp Type I
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Treatment
Small VSD : F/U q 1-2 yr ,
check AR q 2-3 years esp Type I
Moderate or large VSD : treat CHF ,surgery for
repairment before age
at 2 nd years
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Surgery in VSD
Age <6 mo : CHF or recurrent pneumonia or FTT (HC) Age 6-24 mo : moderate or large VSD
P pulmonary a. > P lt venticle 2 times Age >24 mo : Qp : Qs > 2:1 Complication : pericarditis , aortic cusp prolapse ,
murmur of aortic regurgitation (< 10 yr)
Indication for surgery
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Management
1. Support breathing and ventilation
2. Posture : semi-fowler position
3. Decrease physical activities :
rest often and sleep adequately
+/- sedation/analgesia
4. Medication : inotropic support, preload and afterload reduction
5. Diet : increase daily calories, “ no added salt diets ”
6. Correct precipitating cause
7. Surgical correction of CHD if indicated
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Medication in CHF
1. Inotropic supportDigitalis • Loading dose = total digitalization dose = TDD in 24 hr
TDD/2 TDD/4 TDD/4
• Maintainance dose = TDD/4 devided in two given
at 12 hr interval
12 HR 6-8 HR 6-8HR
-Monitor : EKG & rhythm before each of the three digitalizing doses
Serum digoxin when suspected digitalis toxicity
Blood for serum electrolyte before & after administration
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Medication in CHF
1. Inotropic supportA and B -adrenagic agonists IV
Dopamine 2–30 µg/kg/min Dobutamine 2–20 µg/kg/min Isoproterenol 0.01–0.5 µg/kg/min Epinephrine 0.05–1.0 µg/kg/min Norepinephrine 0.1–2.0 µg/kg/min
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Medication in CHF
2. Preload-reducing agentsFurosemide (Lasix)
– IV 1-2 mg/dose prn– PO 1-4 mg/kg/day, divided qd–qid
Bumetanide (Bumex)– IV 0.01-0.1mg/kg/dose– PO 0.05-0.1 mg/kg/day, divided q 6– 8h
Chlorothiazide (Diuril) – PO 20-50 mg/kg/day, divided bid or tid
Spironolactone (Aldactone)– PO 1-3 mg/kg/day, divided bid or tidMonitor serum electrolyte in long term therapy
BW, urine input / output
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3. Afterload-reducing agentsHydralazine (Apresoline)
IV or IM 0.1-0.5 mg/kg/dose (max 20mg )
PO 0.25-1 mg/kg/dose q 6-8h (max 200 mg/day)
Nitroglycerin 0.25-5 µg/kg/min
Nitroprusside (Nipride) IV 0.5-8 µg/kg/min
Captopril (Capoten) PO
Infants 0.1-0.5mg/kg/dose q8-12h (max 4 mg/kg/day)
Prematures: start at 0.01mg/kg/dose
Children 0.1-2 mg/kg/day q 8-12 h
Enalapril (Vasotec) PO
0.08-0.5mg/kg/dose q12-24h (max1mg/kg/day)
monitor : BP ( keep BP post Rx >/= BP pre Rx )
Medication in CHF
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Treatment in this patient
Lasix ( 1 MKDose) 4.5 mg po q 8 hr Aldactone ( 2 MKDay ) 2 ml IV q 12 hr Lanoxin ( TDD 0.04) 0.04 ml po bid x one
day then Dobutamine IV 1 cc/hr
( 1cc/hr = 5ug/kg/day ) Captopril ( 0.1 MKDose ) 0.4 ml po q 8 hr
step to 3 MKDose
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Monitoring in heart failure
Clinical
Dyspnea , tachypnea
Physical exam
Perfusion , RR , Sleeping pulse , liver size and consistency
Input / output per day and body weight
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Progression in this patient
Day 2 : PRC has been given due to Hct 31 % Off lanoxin Captropril has been stepped up to 0.2 MKDay
Day 3 : Captropril has been stepped up to 0.3 MKDay Lanoxin oral has been given Lasix has been given because he looked more dyspnea and weight gain
Day 4 : Off Dobutamine Day 5 : Change lasix to oral form
After treated for 6 days less tachypnea , less dyspnea , liver is soft
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Plan of management
Try medical treatment : Lasix 1 MKDose oral q 12 hrAldactone 2 mg/kg/dayCaptopril 0.3 mg/kg/doseLanoxin TDD 0.04Ferrous sulfate drops 2-3 mg/kg/day Follow up 3 months at cardiology clinic Surgery if failure to thrive or clinical does not improve
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Take home message
– Cardinal sign of CHF : Tachypnea , Tachycardia Hepatomegaly , Cardiomegaly– CHD is vary in clinical presentation– VSD must be referred to treat before 2 yrs– The severity of disease does not depend on
loudness of heart murmur
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Thank you for your attention
Special thanks
Dr. Kritvikrom
Dr.Niran
Dr. Jarupim