exposure to environmental contaminants
DESCRIPTION
Exposure to environmental contaminants. Hg in seafood Acute health effects ( Minimata ) Chronic health effects ( seafood (NY state)) Endocrine disruptors Effects on humans Effects on other animals Long Island Sound data. Heavy Metal Pollution in Water: Pb, As, Hg , Cd, others. - PowerPoint PPT PresentationTRANSCRIPT
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Exposure to environmental contaminants
Hg in seafood Acute health effects (Minimata) Chronic health effects (seafood (NY
state)) Endocrine disruptors
Effects on humans Effects on other animals
Long Island Sound data
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HEAVY METAL POLLUTION IN WATER:
PB, AS, HG, CD, OTHERS
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‘Mad as a Hatter’
Did you know that the Mad Hatter from Alice’s Adventures in Wonderland is modeled after an occupational disease of the 18th and 19th centuries? In that era, hat makers were heavily exposed to mercury used in the preparation of felt. Consequently, many suffered brain damage and became psychotic, or “mad” (Katy, 1979).
Reference: Dennis Coon & John O. Mitterer (2007), Introduction to Psychology, 11th Edition, Wadsworth Cengage Learning
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• Human exposure through fish consumption
• Neurotoxic; Neurodevelopmental effects
• Crosses blood-brain, placental barriers
• Bioaccumulation & biomagnification
Mercury Hg
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MeHg Biomagnification
0 100 200 300 400 500 600 700
Water
Phytoplankton
Zooplankton
Planktivorous Fish
Piscivorous Fish
Total Hg (ppb)
MeHg
Inorganic Hg
Top predators and older, slow growing fish have high MeHg concentrations.
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Exposure route: sediments to fish to consumers
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Minimata Disease, 1956
Over 2,000 victims
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Source: acetaldehyde factory
~25-30 tons released
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USGS
Exact mechanism of action not really known
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% Rivers and Lakes Under Advisory
1993-2004
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Fish Consumption Advisories for Mercury (2004)
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Mercury Exposure in New Yorkers
NYC HANES (Health and Nutrition Examination Survey) 1/4 NYC adults have elevated blood Hg levels
20-49 y old women, average blood mercury level 2.64 µg/L (3x the national average (0.83 µg/L)
WHY??•New Yorkers eat more fish
•Fish consumed by New Yorkers is more contaminated with mercury
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1/4 NYC adults have elevated blood Hg levels
20-49 y old women, 2.64 µg/L (3x national average) ¼ of these ≥ 5 µg/L
<5 µg/L for those who eat fish ≤3 times/week >5 µg/L for those who eat fish ≥ 4 times/week Higher-income adults have higher mercury levels;
highest income bracket 3.6 µg/L, 2.4 µg/L for lowest income group
blood mercury higher among NYC Asian women (4.1 µg/L); 45% have blood mercury levels ≥ 5 µg/L Esp. foreign-born Chinese women; eat ~ 3 fish
meals / week, compared to ~1 among average New Yorker
1/4 Chinese New Yorkers eat fish 5+ times/week
(McKelvey et al. 2007)
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Significance of NYC HANES study
Important source of information about the health of a community
Information about local environment Highlights need for improved education
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FDA Seafood consumption guidelines
“Women who might become pregnant, women who are pregnant, nursing mothers, and young children”.
1. “should include fish and shellfish in their diets. But . . . ”
2. “all fish and shellfish contain . . . mercury . . . those that contain higher levels . . . may harm an unborn baby or young child's developing nervous system”
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Consumption guidelines 21. Do not eat Shark, Swordfish, King Mackerel, or
Tilefish 2. Eat up to 12 ounces (2 meals) a week of fish
and shellfish that are lower in mercury (shrimp, canned light tuna, salmon, pollock, and catfish).
3. You may eat up to 6 ounces (one average meal) of albacore tuna per week.
4. Eat up to 6 ounces (1 meal) per week of fish you catch from local waters, but don't consume any other fish during that week.
Problem: Current recommendations based on fish Hg data from ~1991-2004.
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Risks/Benefits of Fish consumption
Estimated EPA/DHA and MeHg intake from one and two 3-ounce servings of seafood.
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Other water pollutants
Nutrients (eutrophication) POPs (persistent organic pollutants)
PCDDs, mirex, DDT Pharmaceuticals Endocrine disruptors
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Silent Spring
Rachel Carson, 1962 Drew national attention to eggshell thinning
caused by DDT Our Stolen Future, Theo Colborn, 1997
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Endocrine Disrupting Compounds (EDCs)
Chemicals routinely used in industrial processes, agriculture and the production of a variety of domestic products which are able to bind to, and either activate or block endogenous steroid receptors
Widely distributed, environmentally stable and lipophilic
One of six high priority research issues, EPA 1996
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Endocrine Disrupting Compounds (EDCs)
PCBs PAHs Surfactants Plasticizers Steroid hormones Phytoestrogens
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EDCs in the home
Phthalates Food storage containers Polyvinyl chloride (PVC) tubing/products (such
as water pipes) Flexible plastics, plastic bottles
Bisphenol A (BPA) Metal cans of food and infant formula Hard-plastic baby bottles Sippy cups Plastic bottles
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Avoid exposure
How to Avoid Phthalates and BPA: Do not microwave food/beverages in plastic Do not microwave or heat plastic cling wraps Do not place plastics in the dishwasher If using hard polycarbonate plastics (water bottles/baby
bottles/sippy cups), do not use for warm/hot liquids Use safe alternatives such as glass or polyethylene
plastic (symbol #1) Avoid canned foods when possible (BPA may be used in
can linings) Look for labels on products that say “phthalate-free” or
“BPA-free”
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Environmental Relevance
Human Seveso Women’s Health Study (SWHS)
Exposure to relatively pure TCDD (1976) Significant, dose-response increased risk of breast
cancer In males:
Cryptorchidism, hypospadias & decreased sperm counts
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Environmental relevance
Reptile Dicofol (DDT analog) spill by Tower Chemical
Co. in Lake Apopka, Florida, 1980 Compared to reference lakes, juvenile male
alligators exhibited significantly: Smaller penis size (24% average decrease) Lower plasma testosterone levels (70% lower)
Baltic seal body burdens Snails & TBT exposure
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Environmental Relevance--Amphibian
Hayes et al., 2002
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Ovotestis
Schmitt et al., 2005
Largemouth bass testes from Rio Grande
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Arukwe and Goksoyr, 2003
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Long Island Sound
Watershed: 9 million inhabitants; 44 sewage treatment plants (STPs) (1 billion gallons day-1)
Historically used for shipping, fishing and waste disposal
Fluvial input: Connecticut, Housatonic, Quinnipiac, Thames
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Water Quality Indexdissolved inorganic nitrogen, dissolved inorganic phosphorus, chlorophyll a, water clarity, and dissolvedoxygen
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LI Sound
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LI Sound
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LI Sound
PCB concentrations in striped bass from the Sound declined from about 2.5 ppm to less than 0.5 ppm
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Pathogens in LI Sound
Pathogens –disease causing bacteria and viruses
Primarily from stormwater runoff animal waste, human waste
from improperly maintained septic systems
illegal connections to ‘storm sewers’
Older systems combine wastewater and storm water; wastewater transport to STP can overflow during high rainfall events