exposure reconstruction for the epidemiologic study june 2010
TRANSCRIPT
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Exposure Reconstruction for the Epidemiologic Study
June 2010
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Exposure Reconstruction
• Defines common exposure subgroups• Quantifies exposures for subgroups• If there is an excess, then seeks
association between exposures and effects
• If there is no excess effect, exposure reconstruction however refined will not associate an agent with an effect or explain an effect
UIC 2010
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Exposure Reconstruction
• Performed on:– Parts manufactured– Processes used to manufacture parts– Individual agents
• Part and process analyzed to ensure any unsuspected agent that may be associated with a possible effect would not be missed
UIC 2010
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Individually Examined Contaminants
• Cohort– Evaluate mortality and
work exposures• Chromium • Cobalt • Degreasing solvents• Ionizing radiation• Lead-cadmium• Magnetic fields• Metalworking fluids (oil
& water based)• Nickel
• Case-control– Evaluate CNS incidence
and more detailed work exposures
• All of the cohort exposures as well as:
• PCB’s• Metalworking fluid
combustion products specific to North Haven
UIC 2010
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Exposure Reconstruction Protocol
• Leaves no stone unturned– Considers all suspected agents– Considers all employment categories as
defined by job dictionary – Considers all significant subgroups as defined
by parts– Considers all different aspects of work as
defined by manufacturing processes involved
UIC 2010
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UIC 2010
Acknowledgement
The researchers would like to thank the Communications Facilitation Workgroup, P&W employees, union, and management personnel, and the CT Department of Public Health for their continued support and contributions to the study.