explore trilandia with your child to learn about trikafta

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.Talk to your doctor to learn if you have an indicated CF gene mutation.It is not known if TRIKAFTA is safe and effective in children under 6 years of age.

Please see Important Safety Information for TRIKAFTA on pages 4-7, full Prescribing Information at www.TRIKAFTA.com/PrescribingInfo, and Patient Information at www.TRIKAFTA.com/PatientInformation.

Explore Trilandia with your child to learn about TRIKAFTA®

https://pi.vrtx.com/files/uspi_elexacaftor_tezacaftor_ivacaftor.pdf

https://pi.vrtx.com/files/patientpackageinsert_elexacaftor_tezacaftor_ivacaftor.pdf

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About this bookThis book is for caregivers of children with cystic fibrosis (CF) ages 6 through 11 years who have been prescribed TRIKAFTA® by their healthcare provider.

Read it togetherWe encourage you to read this book with your child so you can learn about TRIKAFTA together.

Reach out for answersIf you have any questions about TRIKAFTA, please talk to your child’s healthcare provider and visit TRIKAFTA.com.


www.trikafta.com



3

Meet Trina, Trey, and Cybark!Trina and Trey are siblings who both have CF. But there’s so much more to who they are! Keep reading to learn a bit about them and their trusty robo-dog, Cybark.

TrinaAge: 11Hobbies:

Building gadgets and robots (like Cybark) and reading sci-fi books

Favorite color: Magenta

TreyAge: 9

Hobbies: Drawing, coloring, and reading comics

Favorite color: Blue, like his eyes!

CybarkAge: He doesn’t age!

But Trina built him three years ago

Hobbies: Teaching and playing fetch

Favorite color: Teal




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Who should not take TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?Do not take TRIKAFTA if you take certain medicines such as:• antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin

(MYCOBUTIN®)

• seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)

• St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

What should I tell my doctor about my medical conditions before starting TRIKAFTA? Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:• have kidney problems

• have or have had liver problems

• are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant

• are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

WHAT IS THE IMPORTANT SAFETY INFORMATION?

Please see additional Important Safety Information for TRIKAFTA on pages 5-7, full Prescribing Information at www.TRIKAFTA.com/PrescribingInfo, and Patient Information at www.TRIKAFTA.com/PatientInformation.



5

Are there any other medicines that may interact with TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)? TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one.Especially tell your doctor if you take:• antifungal medicines including ketoconazole (such as NIZORAL®),

itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)

• antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

• other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?• TRIKAFTA can cause dizziness in some people who take it. Do not

drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you

• Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

WHAT IS THE IMPORTANT SAFETY INFORMATION? (Continued)

Please see additional Important Safety Information for TRIKAFTA on pages 4 and 6-7, full Prescribing Information at www.TRIKAFTA.com/PrescribingInfo, and Patient Information at www.TRIKAFTA.com/PatientInformation.



6

What are the possible side effects of TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?TRIKAFTA can cause serious side effects, including:• High liver enzymes in the blood is a common side effect in people

treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:

— before you start TRIKAFTA

— every 3 months during your first year of taking TRIKAFTA

— every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

— pain or discomfort in the upper right stomach (abdominal) area

— yellowing of your skin or the white part of your eyes

— loss of appetite

— nausea or vomiting

— dark, amber-colored urine

• Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts


Please see additional Important Safety Information for TRIKAFTA on pages 4-5 and 7, full Prescribing Information at www.TRIKAFTA.com/PrescribingInfo, and Patient Information at www.TRIKAFTA.com/PatientInformation.



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What were the most common side effects seen with TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?The most common side effects of TRIKAFTA include:• headache

• upper respiratory tract infection (common cold) including stuffy and runny nose

• stomach (abdominal) pain

• diarrhea

• rash

• increase in liver enzymes

• increase in a certain blood enzyme called creatine phosphokinase

• flu (influenza)

• inflamed sinuses

• increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.





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Scientists and doctors gather in this high-tech city. Dr. Lori Laboratory has a lab here with information about how TRIKAFTA® works.


Wherever you go in Trilandia, you’re sure to learn something about TRIKAFTA.Trilandia

This forest is filled with fat-containing food, which comes in handy when it’s time to take TRIKAFTA.

Here you’ll meet the Memory Magician, whose tips and activities will help you remember when and how to take TRIKAFTA.



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Trina was already thinking about finishing her latest robot kit. Trey grabbed his sketchbook, pencils, and his favorite toy robo-dog, Cybark, and headed down to the kitchen with Trina.

“Good morning!” said their mom and dad cheerily.

“Morning!” the siblings replied.

“Remember when we visited Dr. Lori Laboratory at the CF Center?” Dad said. “We discussed starting TRIKAFTA® and asked her a bunch of questions. Well, guess what came in the mail?” He held up a box. “It’s your TRIKAFTA prescription! We just talked to Dr. Lori, and she said you can start it tomorrow.”

“We’re ready,” Trina said with determination.

“Yeah, we are!” shouted Trey.

When Trina and Trey woke up,

it seemed like another

OO RR DD II NN AA RR YY DDAAY.Y.

9




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“Not so fast, tiger!” said Mom. “Whenever you add a treatment to your routine, it’s important to learn all you can about it. Now that you have your prescribed TRIKAFTA®, let’s check out the book Dr. Lori gave us at your last visit.”

“Here it is!” Dad yelled with delight as he pulled out the book from a stack of mail.

“But how?” Trey asked with wide-eyed excitement.

“Just open it and start reading!” Dad responded. “The book takes you through different parts of Trilandia to help you unlock more information about your new treatment. First, you’ll meet Dr. Lori in Science City so she can show you how TRIKAFTA works in the body.”


“This is a very special book that will take you to a place called TRILANDIA,” Dad said.



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“If you want a break or need directions,” said Mom as she gave the siblings their backpacks, “you’ll find some snacks and a map of Trilandia in here.”

"Cybark will help you keep in touch with us and get you to your destinations safely."

Trina and Trey adjusted their backpacks and gave their parents a quick hug. They looked at each other, clasped hands, and opened the first page of the book. As they began to read, they felt like they were being transported into another world. They could hardly wait to learn more about their new treatment.




12

After reading a few pages, Trina and Trey glanced up at each other in surprise— suddenly, they were wearing new gadgets and accessories. Then they looked up and realized they weren’t in their kitchen anymore. A dirt road lay beneath their feet, forking off into several different paths. Trina hurriedly pulled out a map of Trilandia to plot their course to Science City.

“Arf-arf-of-course!” barked Cybark. Trina and Trey gasped in amazement. “Oh, didn’t you know that in Trilandia, I can talk?” he said. “And I have some other upgrades that can help you on all your adventures!”

"Reading really does take youto other worlds!" Trey exclaimed.




13

Retrieves and downloads tons of

information

Projects information from Dr. Lori

Calls Mom and Dad so they’re always

with Trina and Trey

Uses supersonic sniffing to locate people and objects

CYBARK’S UPGRADES




14

It wasn’t long before they arrived in Science

City, with its circuit trees and tall, gleaming buildings. Trey, who was

always very curious, had a whole beehive of questions buzzing around in his brain. He turned to his sister and asked, “What is TRIKAFTA®?

How does it work? And how often do I take it?”




15

“That’s quite a lot of questions!” said Cybark. “Before we learn how TRIKAFTA® works, do you two know what causes your CF?”

“I know a little about it,” Trina said. “Basically, our genes have changes, or mutations, in them. And that’s what causes CF. Right, Cybark?”

In Trilandia, he could access tons of CF information from Dr. Lori. Now, he was ready to help the siblings remember everything Dr. Lori had taught them. “Let me show you,” he said as he began projecting from his collar.

yelped Cybark with excitement.




16

CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator, or CFTR, gene. Everyone has 2 copies of this gene. If both copies have a mutation, the CFTR proteins produced from those genes don’t work like they should.

THE UNDERLYING CAUSE

DEFECT 1: Fewer CFTR

proteins get to the cell surface, where they are

normally located.

DEFECT 2: CFTR proteins don’t open correctly if they do reach the cell surface.

These defects can cause thick, sticky mucus to build up in organs, like the lungs.

CELL: A building block of life— your entire body is made up of cells! Different cells create different proteins, including CFTR proteins.

CFTR PROTEIN: A channel, or tunnel, that lets water and chloride ions into and out of the cell through a gate.

CHLORIDE ION: A particle that is part of salt. When it moves into and out of cells, water goes with it, which helps keep mucus thin and free-flowing.

MUCUS: A slippery substance that lines many different organs.




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“Whoaaa,” said Trey. “I didn’t know all that was happening inside my body!”

“Now I’m even more curious to see how TRIKAFTA® works,” said Trina.

With the help of Cybark’s supersonic sniffer, Trina and Trey found Dr. Lori’s lab at the tippy-top of a very tall and very shiny building. The lab doors opened with a whooosh. The siblings looked around in awe at all the high-tech equipment.

“Welcome!” boomed Dr. Lori, with a coffee cup in her hand and a smile as bright as the sun.

“I’m glad you made it here so quickly,” she said as she finished her coffee and greeted the siblings. “We are going to learn so much today! But first—tell me what you already know about CF.”

“We know our CFTR proteins don’t work the way they should,” Trey responded, “but we don’t know how TRIKAFTA works.”

“Well, this sounds like the perfect time for a little field trip,” said Dr. Lori. “Quick! To my shrinking spaceship!”

“You have a spaceship that shrinks?!?” Trina said with delight.

“Of course!” said Dr. Lori. “We’ll use it to see how TRIKAFTA works in a cell with CF.”




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“All 3 parts come together to help CFTR proteins work better. Elexacaftor and tezacaftor help more proteins reach the cell surface. Then, ivacaftor helps the proteins stay open longer.”

“Why do we need more CFTR proteins at the surface? And why do they need to stay open longer?” Trey asked.

“If I remember correctly,” replied Trina, “the more CFTR proteins there are at the surface—and the longer they stay open—the more chloride ions can move into and out of the cells. That helps the mucus stay thin and free-flowing.”

IMPORTANT SAFETY INFORMATIONWhat are the possible side effects of TRIKAFTA? TRIKAFTA can cause serious side effects, including:• High liver enzymes in the blood is a common side effect in people

treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:— before you start TRIKAFTA— every 3 months during your first year of taking TRIKAFTA— every year while you are taking TRIKAFTA

CELL

CFTR PROTEIN

CHLORIDE ION

ELEXACAFTOR

TEZACAFTOR

IVACAFTOR

“I know your parents know this, but did you know that TRIKAFTA® is actually made up of 3 different parts, called elexacaftor, tezacaftor, and ivacaftor?” said Dr. Lori.

18




19

“That’s right!” said Dr. Lori. “I think you guys have got it.”

“You’re both learning so fast,” said Cybark proudly. “It’s woof-woof-wonderful!”

CYBARK HAS A NEW MESSAGE FROM MOM AND DADCongratulations, kids! Now that you know how TRIKAFTA® works, it’s time to figure out how to take it. Head to the Forest of Flavorful Foods for your next adventure!

IMPORTANT SAFETY INFORMATION (Continued)Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

— pain or discomfort in the upper right stomach (abdominal) area— yellowing of your skin or the white part of your eyes— loss of appetite— nausea or vomiting— dark, amber-colored urine

• Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

19

CELL

CFTR PROTEIN

CHLORIDE ION

ELEXACAFTOR

TEZACAFTOR

IVACAFTOR




20

With Science City far behind them, Trina and Trey wanted to rest up before entering the Forest of Flavorful Foods. They found a little creek and decided to sit beside it.

While Trina rummaged around in her backpack for a snack, Trey found that the round stones on the bank were perfect for skipping across the crystal-clear water. He easily made some lighter stones skip at least three times before they sank. Then he wanted a new challenge. He tossed a bigger, heavier stone with all his might across the creek, crossing his fingers for at least one skip. And…it sank with a plunk, making a new question buzz around in his brain.

“Hey, Cybark, do all kids take the same amount of TRIKAFTA®?” he asked. “Because we’re all different sizes, like these stones, and they don’t all skip the same way.”

“Good question!” Cybark replied. “If you weigh more, you might get a different dose of TRIKAFTA. That’s why it’s always important to only take your own TRIKAFTA as your doctor tells you. Let’s call your parents and take a look at this information that I downloaded at Dr. Lori’s lab.”

MOM & DAD Calling...




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RECOMMENDED DOSE FOR AGES 6 THROUGH 11 YEARS

Take 2 light orange AM tablets (50 mg elexacaftor, 25 mg tezacaftor,

and 37.5 mg ivacaftor)

If your child weighs less than 30 kg (66 lbs)

Take 2 orange AM tablets (100 mg elexacaftor, 50 mg tezacaftor,

and 75 mg ivacaftor)

Take 1 light blue PM tablet (150 mg ivacaftor)

If your child weighs 30 kg (66 lbs) or more

About 12 hours later

Take 1 light blue PM tablet (75 mg ivacaftor)

About 12 hours later

Who should not take TRIKAFTA® (elexacaftor/tezacaftor/ ivacaftor and ivacaftor)?Do not take TRIKAFTA if you take certain medicines such as:• antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®) • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®,

CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)• St. John’s wortTalk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

IMPORTANT SAFETY INFORMATION




22

Are there any other medicines that may interact with TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one.Especially tell your doctor if you take:• antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such

as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)

• antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

• other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

IMPORTANT SAFETY INFORMATION

GUIDANCE FOR TAKING EACH DOSE

Your child should always take TRIKAFTA with a meal or snack that contains fat to help the body absorb the medicine.

Talk to your healthcare provider about all the medicines your child takes, as the dose of TRIKAFTA may need to be adjusted. Make sure your child takes every dose of TRIKAFTA exactly as prescribed by their doctor. Because the 3 parts of TRIKAFTA work together, each and every dose matters.

Avoid foods and drinks that contain grapefruit while taking TRIKAFTA because they may affect the amount of TRIKAFTA in the body.




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• Whole-milk yogurt cup• Boiled eggs• Peanut butter and jelly sandwich • String cheese• Bagel with cream cheese• Slice of pepperoni and cheese pizza• Trail mix with nuts• Chips and guacamole• A glass of whole milk

Avoid foods and drinks that contain grapefruit while taking TRIKAFTA

because they may affect the amount of TRIKAFTA in the body.

Fat-containing snacks to look for in the forest:

“I bet we’re going to find many different fat-containing foods in the forest that we can eat when we take TRIKAFTA®,” said Trina.

“Look, it’s right ahead of us!” Trey said. “Is that a yogurt tree?” He gasped. “Check out all the different flavors!”

As the trio entered the forest, Cybark’s collar went ba-ding with a new message from Mom and Dad.

“You made it to the forest!” said Dad. “Now that you know how important it is to take each dose with fat-containing food, we have a task for you. Search the forest for fat-containing snacks. Here’s a list to help you.”




24


“Happy searching!” said Dad.

“All right, let’s start looking for some of these snacks,” said Trina as she set down her backpack and surveyed the forest.

“I know where I’m heading first!” shouted Trey, promptly running off toward a yogurt tree.



25

With their backpacks full of foods from the forest, Trina and Trey were ready to get back on the road.

“Guys, wait up!” shouted Trey, with his and Trina’s backpacks slung over his shoulders.

“Oh no, did I forget it again?” Trina said apologetically. She tended to be a little forgetful. “Wait, what happens if I forget a dose of my TRIKAFTA?”

“Why don’t we ask Dr. Lori?” said Cybark, letting out a bleep-blip-bloop as he contacted the doctor.

“Hello!” said Dr. Lori as Cybark projected her image. “I’m thrilled to see you both again. What can I do for you?”

“We wanted to know what to do if we miss a dose of TRIKAFTA,” said Trey.

“Your parents should know what to do,” said Dr. Lori. “In fact, let’s call them now so we can go over it together!”

CYBARK HAS A NEW MESSAGE FROM MOM AND DADNice job, kids! You’ve found the fat-containing food in the forest.

Now that you know how TRIKAFTA® is taken, it’s time to get some tips to remember when to take it. Your next adventure awaits you

at Keep-in-Mind Carnival!




26

WHAT TO DO IF A MORNING DOSE WAS MISSED

Do not take more than the usual dose of TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor) to make up for a missed dose.

If it’s been 6 hours or LESS since the morning dose is usually taken:• Take the missed dose with fat-containing food as soon as possible• Then take the next dose at the usual time with fat-containing food

If it’s been MORE than 6 hours since the morning dose is usually taken:• Take the missed dose with fat-containing food as soon as possible• Then do not take the evening dose. Resume regular dosing

schedule the next day

If it’s been 6 hours or LESS since the evening dose is usually taken:• Take the missed dose with fat-containing food as soon as possible• Then take the next dose at the usual time with fat-containing food

If it’s been MORE than 6 hours since the evening dose is usually taken:• Do not take the missed dose• Take the next morning dose at the usual time with

fat-containing food

WHAT TO DO IF AN EVENING DOSE WAS MISSED

“This is really helpful if I ever miss a dose,” said Trina. “I’m going to try my best not to. I just need some ways to help me remember to take it.”

“Well, if you’re headed to Keep-in-Mind Carnival, ask for the Memory Magician,” said Dr. Lori. “He can help you and your parents with that.”




As they entered Keep-in-Mind Carnival, the siblings took in sights, sounds, and smells from across the land. Each food cart had a different snack from the Forest of Flavorful Foods—from ice cream to string cheese to so much more! And everywhere they turned, they saw rides and games that reminded them of all the things they had learned in Science City. Trina’s eyes were drawn to a rocket-themed roller coaster rumbling above her.

“Ooh, I could spend all day here,” said Trina. “Look!” she shouted, pointing to a mysterious man wearing a long cape and a top hat, standing next to a carnival booth. “I think that’s him.”

27

Please see Important Safety Information for TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor) on pages 4-7, full Prescribing Information at www.TRIKAFTA.com/PrescribingInfo, and Patient Information at www.TRIKAFTA.com/PatientInformation.



28

“Um, excuse me, Mr. Memory Magician?” Trey asked politely as he approached the man.

“Yes!” answered the man, with a raised eyebrow. “It is I, the Memory Magician! At your service!” he said with a deep bow and a dramatic swish of his cape.

“Dr. Lori told us to come find you,” Trey replied. “She said you’d give us some ideas for remembering to take our TRIKAFTA®.”

“But of course,” said the Memory Magician as he twisted his long, thin mustache. “Watch closely.”

“I’m going to need some assistance for these tips,” said the magician as he opened his large cape, “from two people who can help you make TRIKAFTA a part of your routine.” He dropped the cape, revealing:

“Mom! Dad!” Trina exclaimed. “How did you get here?!”

“SHH, it’s magic!” whispered Mom, with a twinkle in her eye.




29

“Now, one way to remember your morning and evening doses is to take them with a meal, like breakfast,” the magician said, signaling Mom to reach into the hat. Trina and Trey gasped in amazement as she pulled out a steaming plate of eggs and sausage. “Or dinner,” he said. When Dad pulled out a plate full of macaroni and cheese, the aroma made the siblings’ stomachs grumble.




30

The most common side effects of TRIKAFTA include:• headache• upper respiratory tract infection

(common cold) including stuffy and runny nose

• stomach (abdominal) pain• diarrhea• rash• increase in liver enzymes• increase in a certain blood enzyme called

creatine phosphokinase• flu (influenza)• inflamed sinuses• increase in blood bilirubinThese are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

“You can also ask your parents to set reminders on a phone or calendar,” said the magician with a wave of his wand. Cybark let out a yip! before disappearing in a puff of smoke. “Or, in your case, your robo-dog can remind you,” he said as Cybark reappeared in his hands.

“Another idea may be to give you a sticker for every day you take your TRIKAFTA,” said the magician as shiny stickers appeared all over Cybark. “Try putting them on a calendar to help you track your treatment.”

“Whoa!” Trey exclaimed as a very sparkly Cybark scurried back to them.

“Thanks for the tips, Mr. Magician!” said Dad as he gave the man a pat on the back. “You’ve taught all of us something new today.”

WHAT ARE THE MOST COMMON SIDE EFFECTS

OF TRIKAFTA®?




31

“Great work, kids!” said Dad proudly. “Now it’s time to head back home.”

“We just need to read the last page of the book,” Mom said. “Trina, will you do the honors?”

Trina pulled the book out of her backpack. She flipped to the last page and began to read. “‘You and your child have learned so much about TRIKAFTA® in each of your adventures,’” she read. “‘Now your child is ready to start their new treatment! Just remember, talk to your child’s doctor if you have any questions about TRIKAFTA.’”

When Trina looked up from the book, she realized they were back at home. The sun had set, and Trey was fast asleep. Cybark was tucked safe and sound against his chest. Trina let out a long yawn.




Mom slipped the book out of Trina’s arms and placed it on the shelf.

“Once you start TRIKAFTA®,” she said, “remember that Dad and I will always be there to help you, along with Dr. Lori and the rest of your CF care team. And whenever you want, we can read this book again to remind ourselves of all we’ve learned. But right now, it’s time for bed.”

With Trina trailing behind him, Dad carried a drowsy Trey up the stairs to bed. The siblings couldn’t wait to use all the information they’d learned about TRIKAFTA. Tomorrow was the start of a new day.

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TRIKAFTA is manufactured for Vertex Pharmaceuticals Incorporated.TRIKAFTA, the TRIKAFTA logo, Vertex, and the Vertex triangle logo are registered trademarks of Vertex Pharmaceuticals Incorporated.All other trademarks referenced herein are the properties of their respective owners.© 2021 Vertex Pharmaceuticals Incorporated | VXR-US-28-2100043 (v1.0) | 06/2021

explore trilandia with your child to learn about trikafta

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