experiment number: 20316 - 02 p09: non-neoplastic lesions ... · test type: 90-day cedarwood oil...
TRANSCRIPT
![Page 1: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/1.jpg)
F1_Rev.1_M3NTP Study Number: C20316
Lock Date: 03/06/2006
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 3.0.2.0_001
PWG Approval Date: NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
![Page 2: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/2.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 8 1.0
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10Inflammation, Chronic Active 2 1 2.0
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
![Page 3: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/3.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Accessory Adrenal Cortical Nodule 2 1 2.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Ectopic Thymus 2 1 2.0
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland + + + + + + + + + + 10
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
![Page 4: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/4.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M 0
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
![Page 5: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/5.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010 * TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Metaplasia, Osseous 1 1 1.0
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
![Page 6: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/6.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 7 1.0Necrosis, Focal 1 1 1.0
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
![Page 7: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/7.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Accessory Adrenal Cortical Nodule 2 2 2 2.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + M + + + + 9Cyst 3 1 3.0
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland + + + + + + + + + + 10
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
![Page 8: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/8.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10Ectopic Parathyroid Gland 1 1 1.0
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M 0
Skin + + + + + + + + + 9
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
![Page 9: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/9.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020 * TOTALS
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Thrombosis 2 1 2.0
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 1 1 2 1.0
Urinary Bladder + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
![Page 10: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/10.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 2 1 1 1 6 1.2
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 1 1 1 1 1 5 1.0
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 3 1 3.0
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 2 2 2 2 2 2 6 2.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
![Page 11: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/11.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 2 2 2 2 3 10 2.6Sebaceous Gland, Site Of Application,
Hyperplasia1 2 1 1 1 1 1 1 2 2 10 1.3
Site Of Application, Inflammation, ChronicActive
3 3 2 3 2 2 2 2 2 3 10 2.4
Site Of Application - Dermis, Fibrosis 3 3 2 3 2.7Site Of Application - Epidermis, Hyperkeratosis 3 3 2 2 1 1 3 7 2.1Site Of Application - Epidermis, Hyperplasia 3 3 3 3 2 2 2 2 3 3 10 2.6Site Of Application - Epidermis, Ulcer 4 4 2 4.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
![Page 12: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/12.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00021
00022
00023
00024
00025
00026
00027
00028
00029
00030 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
![Page 13: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/13.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0080
0093
0093
0093
0093
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
ALIMENTARY SYSTEM
Esophagus + 1
Gallbladder + 1
Intestine Large, Cecum + 1
Intestine Large, Colon + 1
Intestine Large, Rectum + 1
Intestine Small, Duodenum + 1
Intestine Small, Ileum + 1
Intestine Small, Jejunum + 1
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 8 1.0Hepatocyte, Depletion Glycogen 1 2 1 3 1 3 6 1.8
Pancreas + 1
Salivary Glands + 1
Stomach, Forestomach + 1
Stomach, Glandular + 1
CARDIOVASCULAR SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
![Page 14: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/14.jpg)
DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0080
0093
0093
0093
0093
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
Blood Vessel + 1
Heart + 1
ENDOCRINE SYSTEM
Adrenal Cortex + 1
Adrenal Medulla + 1
Islets, Pancreatic + 1
Parathyroid Gland + 1
Pituitary Gland + 1
Thyroid Gland + 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland + 1
Epididymis + 1
Preputial Gland + 1
Prostate + 1
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0080
0093
0093
0093
0093
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
Seminal Vesicle + 1
Testes + 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 1 2 1 1 1 3 1 2 2 2 10 1.6
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 2 4 3 3 2 4 6 3.0
Lymph Node, Mesenteric + 1
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 2 2 2 2 2 3 2 2 3 3 10 2.3
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland M 0
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 2 3 3 2 2 2 3 2 10 2.3
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 3 2 3 3 3 3 3 3 10 2.9
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0080
0093
0093
0093
0093
12.5 %ANIMAL ID
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040 * TOTALS
Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 4 4 4 4 4 4 4 8 4.0
MUSCULOSKELETAL SYSTEM
Bone + 1
NERVOUS SYSTEM
Brain + 1
RESPIRATORY SYSTEM
Lung + 1
Nose + 1
Trachea + 1
SPECIAL SENSES SYSTEM
Eye + 1
Harderian Gland + 1
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 1 1 1.0
Urinary Bladder + 1
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 7 1.0Hepatocyte, Depletion Glycogen 3 2 2 2 1 3 2 3 2 9 2.2
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 3 1 2 3 2 2 3 3 1 1 10 2.1
Lymph Node, Mandibular + + + + + M + + + + 9Hyperplasia, Lymphoid 3 2 3 2 3 5 2.6
Spleen + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Hematopoietic Cell Proliferation 3 3 2 2 2 2 2 3 3 3 10 2.5
Thymus + + + + + + + + + + 10Atrophy 1 2 2 2 2 5 1.8
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 3 2 3 3 2 3 3 3 10 2.6
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 4 4 4 4 2 4 4 4 4 10 3.8
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
NONE
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 1 1 2 1.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0077
0093
0093
0093
0093
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Hematopoietic Cell Proliferation 1 1 1.0Inflammation, Chronic Active 1 1 2 1.0Necrosis, Focal 1 1 1.0Hepatocyte, Depletion Glycogen 3 3 3 3 3 3 3 3 3 3 10 3.0
Mesentery + 1Fat, Fibrosis 2 1 2.0Fat, Necrosis 4 1 4.0
Pancreas + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0077
0093
0093
0093
0093
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Accessory Adrenal Cortical Nodule 2 2 2 2.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Follicle, Degeneration 2 1 2.0
GENERAL BODY SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0077
0093
0093
0093
0093
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
GENITAL SYSTEM
Coagulating Gland + + + + + + + + + + 10
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 3 3 3 2 2 3 3 3 3 3 10 2.8
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 3 3 3 4 3 4 3 3 3 9 3.2
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 3 3 3 3 3 3 3 3 3 3 10 3.0
Thymus + + + + + + + + + + 10Atrophy 1 1 2 3 2 2 1 1 2 2 10 1.7Ectopic Parathyroid Gland 1 1 1.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0077
0093
0093
0093
0093
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M 0
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Dilatation 2 1 2.0Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia3 2 2 2 2 2 3 2 3 2 10 2.3
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 2 3 3 3 3 3 10 2.9Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 4 4 4 4 4 1 4 4 9 3.7
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
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DAY ON TEST
B6C3F1 MICE MALE
0093
0093
0093
0093
0093
0077
0093
0093
0093
0093
50 %ANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060 * TOTALS
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 2 1 1 3 1.3
Urinary Bladder + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
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DAY ON TEST
B6C3F1 MICE MALE
0065
0065
0065
0065
0065
0064
0065
0065
0065
0065
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Infarct X 1Inflammation, Chronic Active 1 1 1.0Necrosis, Focal 1 2 2 1.5Hepatocyte, Depletion Glycogen 3 3 3 3 3 3 3 3 3 3 10 3.0
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
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DAY ON TEST
B6C3F1 MICE MALE
0065
0065
0065
0065
0065
0064
0065
0065
0065
0065
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10Cyst 2 1 2.0
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Follicle, Degeneration 2 1 2 1.5
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
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DAY ON TEST
B6C3F1 MICE MALE
0065
0065
0065
0065
0065
0064
0065
0065
0065
0065
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Epididymis + + + + + + + + + + 10
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 4 4 4 4 4 4 4 4 4 4 10 4.0
Lymph Node + + + + + + + + + 9Axillary, Hyperplasia, Lymphoid 4 4 4 4 4 4 4 3 4 9 3.9
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 4 4 3 3 3 3 4 3 8 3.4
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 3 3 3 3 2 3 3 3 3 3 10 2.9
Thymus + + + + + + + + + + 10Atrophy 3 3 1 1 1 1 1 2 2 3 10 1.8
INTEGUMENTARY SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
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DAY ON TEST
B6C3F1 MICE MALE
0065
0065
0065
0065
0065
0064
0065
0065
0065
0065
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Mammary Gland M M M M M M M M M M 0
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Dilatation 2 1 2.0Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 2 2 2 2 2 2 2 2 10 2.0
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 4 4 3 3 10 3.2
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 2 2 3 3 3 4 3 3 10 2.9Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 3 4 4 4 4 4 4 4 4 4 10 3.9
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
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DAY ON TEST
B6C3F1 MICE MALE
0065
0065
0065
0065
0065
0064
0065
0065
0065
0065
100 %ANIMAL ID
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070 * TOTALS
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1.0Nephropathy 1 1 1 1 1 5 1.0
Urinary Bladder + + + + + + + + + + 10
*** END OF MALE DATA ***
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 1 1 10 1.0
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Accessory Adrenal Cortical Nodule 2 1 2.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + M 9
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10Endometrium, Hyperplasia, Cystic 2 1 2.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
![Page 32: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/32.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 2 2 2 2 4 2.0Inflammation, Chronic Active 2 1 2.0
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Sebaceous Gland, Site Of Application,
Hyperplasia1 1 1.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
![Page 33: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/33.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080 * TOTALS
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
![Page 34: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/34.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 1 1 10 1.0
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10Mineralization 1 1 1.0
CARDIOVASCULAR SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
![Page 35: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/35.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + M 9
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Ectopic Thymus 2 1 2.0
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10Decidual Reaction 4 1 4.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
![Page 36: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/36.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
Endometrium, Hyperplasia, Cystic 2 2 2 2.0
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 3 1 3.0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 2 2 2 2.0
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
![Page 37: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/37.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090 * TOTALS
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Urinary Bladder + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
![Page 38: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/38.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 8 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 2 1 2 1.5
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 4 2 3 3 2 2 6 2.7
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 2 2 2 2 2 2 3 1 3 9 2.1
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
![Page 39: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/39.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 2 3 2 3 2.3Sebaceous Gland, Site Of Application,
Hyperplasia1 1 2 1 4 1.3
Site Of Application, Inflammation, ChronicActive
3 2 2 3 2 2 2 2 2 2 10 2.2
Site Of Application - Dermis, Fibrosis 1 1 2 1.0Site Of Application - Epidermis, Hyperkeratosis 1 2 2 1.5Site Of Application - Epidermis, Hyperplasia 3 2 2 3 2 2 2 1 2 2 10 2.1Site Of Application - Epidermis, Ulcer 2 4 2 3.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
![Page 40: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/40.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
URINARY SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 2 1 1 1 1 1 1 1 9 1.1Hepatocyte, Depletion Glycogen 2 2 1 1 1 5 1.4
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 2 1 2 1 1 1 2 1 2 9 1.4
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 3 2 3 3 4 3 6 3.0
Spleen + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
Hematopoietic Cell Proliferation 3 2 3 3 3 3 3 3 2 2 10 2.7
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 2 2 2 2 2 2 2 2 10 2.0
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Site Of Application - Dermis, Fibrosis 3 3 3 3 2 3 3 3 3 3 10 2.9Site Of Application - Epidermis, Hyperkeratosis 3 3 2 3 2 3 3 2 3 3 10 2.7Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 2 4 4 4 4 6 3.7
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 42
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110 * TOTALS
NONE
URINARY SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 43
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 1 9 1.0Hepatocyte, Depletion Glycogen 2 2 1 2 3 2 3 2 2 9 2.1
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
NONE
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0
Lymph Node + 1Hyperplasia, Lymphoid 4 1 4.0
Lymph Node, Mandibular + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 44
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
Hyperplasia, Lymphoid 3 4 4 3 4 5 3.6
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 3 3 3 3 2 2 3 3 2 2 10 2.6
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 2 2 3 2 2 3 2 2 10 2.2
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 4 4 4 4 4 4 4 4 9 4.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 45
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DAY ON TEST
B6C3F1 MICE FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00111
00112
00113
00114
00115
00116
00117
00118
00119
00120 * TOTALS
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 46
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DAY ON TEST
B6C3F1 MICE FEMALE
0071
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10Diverticulum 4 1 4.0
Liver + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1 1 1 1 1 1 1 1 10 1.0Tension Lipidosis 1 1 1.0Hepatocyte, Depletion Glycogen 3 3 3 2 2 3 3 3 1 2 10 2.5
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 47
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DAY ON TEST
B6C3F1 MICE FEMALE
0071
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + M + + M 8
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 48
![Page 49: Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS ... · Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53 Route: SKIN APPLICATION CAS Number: 8000-27-9 First](https://reader034.vdocuments.us/reader034/viewer/2022050118/5f4f02cc190b54262a09d941/html5/thumbnails/49.jpg)
DAY ON TEST
B6C3F1 MICE FEMALE
0071
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Uterus + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0
Lymph Node + + 2Hyperplasia, Lymphoid 4 1 4.0Axillary, Hyperplasia, Lymphoid 4 1 4.0
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 4 4 2 3 4 4 6 3.5
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 3 3 3 3 3 3 3 3 3 3 10 3.0
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 2 2 2 2 2 2 2 2 10 2.0
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 49
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DAY ON TEST
B6C3F1 MICE FEMALE
0071
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 4 4 4 4 4 4 4 4 4 10 4.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Nephropathy 1 1 1.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 50
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DAY ON TEST
B6C3F1 MICE FEMALE
0071
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Urinary Bladder + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 51
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DAY ON TEST
B6C3F1 MICE FEMALE
0066
0066
0066
0066
0066
0066
0066
0065
0066
0066
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Gallbladder + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Infarct X 1Inflammation, Chronic Active 1 1 1 1 1 1 1 1 8 1.0Hepatocyte, Depletion Glycogen 3 3 3 3 4 4 4 4 3 4 10 3.5Hepatocyte, Necrosis 1 1 1.0
Pancreas + + + + + + + + + + 10
Salivary Glands + + + + + + + + + + 10
Stomach, Forestomach + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 52
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DAY ON TEST
B6C3F1 MICE FEMALE
0066
0066
0066
0066
0066
0066
0066
0065
0066
0066
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + M + + + + + + + 9
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
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DAY ON TEST
B6C3F1 MICE FEMALE
0066
0066
0066
0066
0066
0066
0066
0065
0066
0066
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Uterus + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Myeloid Cell, Hyperplasia 4 4 4 4 4 4 4 4 4 4 10 4.0
Lymph Node + + + + + + + + + + 10Axillary, Hyperplasia, Lymphoid 4 4 3 3 3 3 4 4 4 4 10 3.6
Lymph Node, Mandibular + + + + + + + + + + 10Hyperplasia, Lymphoid 4 4 4 3 3 3 4 3 2 4 10 3.4
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 3 3 3 3 3 3 3 3 3 3 10 3.0
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Dilatation 3 2 2 3 2.3Hair Follicle, Site Of Application, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Sebaceous Gland, Site Of Application,
Hyperplasia2 2 2 2 2 3 2 2 3 2 10 2.2
Site Of Application, Inflammation, ChronicActive
3 3 3 3 3 3 3 3 3 3 10 3.0
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
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DAY ON TEST
B6C3F1 MICE FEMALE
0066
0066
0066
0066
0066
0066
0066
0065
0066
0066
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Site Of Application - Dermis, Fibrosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 4 4 4 4 4 4 4 4 4 4 10 4.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Inflammation, Chronic Active 2 1 2 1.5
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
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DAY ON TEST
B6C3F1 MICE FEMALE
0066
0066
0066
0066
0066
0066
0066
0065
0066
0066
100 %ANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140 * TOTALS
Urinary Bladder + + + + + + + + + + 10
*** END OF REPORT ***
Experiment Number: 20316 - 02 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:27:53
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/14/05 / 06/13/05Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 56