expanding global food supply by significantly increasing ... · pdf fileexpanding global food...

14
©2017 | www.agribodytech.com 1 Expanding Global Food Supply by Significantly Increasing Crop Yields Using Patented Gene Technology Jerry Feitelson, Ph.D., Co-Founder & CEO | [email protected] | (858) 349-3603

Upload: phamnhan

Post on 06-Mar-2018

218 views

Category:

Documents


3 download

TRANSCRIPT

Page 1: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 1

Expanding Global Food Supply by Significantly

Increasing Crop Yields Using Patented Gene Technology

Jerry Feitelson, Ph.D., Co-Founder & CEO | [email protected] | (858) 349-3603

Page 2: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 2

THE

PROBLEM

• YIELD: Highest value trait to farmers

Conventional breeding reaching yield limits

• Tens of $Billions in crop loss caused by:

Post-harvest senescence

Disease (bacterial and fungal pathogens)

Stress (drought, low nutrients, salt, cold, heat)

Page 3: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

3

OURDISRUPTIVESOLUTION

License or co-develop

proprietary Genome Edited seeds

with innovative seed companies in

forage, row or specialty crops

having

ULTRA HIGH YIELD &

STRESS RESISTANCE. -- Avoid GMO controversies --

Page 4: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 4

Hypusine

eIF-5ADHS

How? Genetically modify a biological switchThe eIF-5A/DHS hypusination pathway promotes either cell growth/division or cell death (apoptosis)

−Lysine

eIF-5A

Cell Growth/

Division

Cell

Apoptosis

• Increased biomass and seed yield

• Enhanced tolerance to stress & disease

+

Page 5: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 55

Market Opportunity2014 Crop (not Seed) Production: $23.5 Billion

$0.0

$1.0

$2.0

$3.0

$4.0

$5.0

$6.0

$7.0

$8.0

$9.0

Hay & Alfalfa Cotton Sugarbeets Canola Potatoes Rice Sorghum

33%

2014 U.S. Production (Bil)

82%

95%

87%

<5%

<5%

<5%

% GM Adoption

Bil

Page 6: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 66

• Broad Coverage

− 16 issued US Patents + 5 published US Patent Applications

− Foreign counterparts in several countries

− New applications for genome editing of DHS

− CRISPR license from Benson Hill Biosystems

• Matter & Methods claims

− eIF-5A overexpression has important phenotypes

• Higher seed & biomass yields

• Tolerance to abiotic stresses

− DHS knock-downs have clear phenotypes

• Delayed senescence

• Larger leaves

• Higher seed yields

• Stress tolerance

Strong IP Portfolio

Page 7: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

7©2017 | www.agribodytech.com

1. Co-development started with 3rd largest

alfalfa seed company

2. License or Co-develop with seed companies in

12 other targeted crops (@ 2-3/yr)

− 3 crops between Seed & Series A rounds

3. Generate revenue from:

− Licensees:

o Tech Access Fees ($50-150K)

o Benchmark Payments ($2Mil)

o Royalties (5%)

− Co-Development Partners:

o Sales of partially-owned seeds (25 – 33%)

Business Model / Sales

$Partner.

License / Co-Develop.

Generate Revenue.

Page 8: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

8©2017 | www.agribodytech.com

Single transgenes − Rare to boost yields >10% in greenhouse

− Few successful field trials

− Higher photosynthetic efficiency / C3 → C4

− Candidates for stressT

CompetitionMajor Ag Biotech / Ag Chem Companies Small- & Mid-size Companies

Agribody

TechnologiesEvoGene

Arcadia

BiosciencesCeres

Kapyon/

ZeaKal

Yield10

BioscienceKaiima

Improved

YieldX X X X X X X

Biotic

Stress

Tolerance

Bacteria,

Fungi

Nematode,

Fungi,

Insect,

Aphids

Fungi

Abiotic

Stress

Tolerance

Drought,

Crowding,

Low Nutrient

Drought

Drought,

Nitrogen

Efficiency,

Salt

Drought,

Poor SoilsDrought

Enhanced

Shelf Life

Tomato,

Banana,

Carnation

TILLING in

Tomato

Public, VC

or PrivateStart-Up NYSE NASDAQ NASDAQ VC

VC /

NASDAQVC

Major Ag Biotech / Ag Chem Companies

− GM traits for increasing yields indirect: insectR / herbicideT

− Extensive R&D on pathogen and abiotic stress resistance

− Potential acquirer

Page 9: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 99

ATI Executive Team

Paul Kreutz

Corporate Counsel

• Represented many VC firms

• Counsels & helps structure

growth-oriented

entrepreneurial enterprises

• B.A. (Yale), LL.B. (Stanford)

Jerry Feitelson, Ph.D.

CEO / Co-Founder

• >30 years R&D, IP,

Licensing & Bus Dev

experience

• Managed $10Mil royalties;

Negotiated $7Mil license

• Patented B.t.

genes/proteins lead to

$850Mil valuation

• B.S. (MIT), Ph.D. (Stanford)

John Thompson, Ph.D.

Chief Scientist / Co-Founder

• U. of Waterloo (Professor

Emeritus, Associate VP)

• Invented eIF-5A/DHS

technology

• B.S. (Toronto), Ph.D.

(Alberta), Fellow of Royal

Society of Canada

Jim Goode

Acting CFO

• 35 years managing financial/

admin functions of high-tech,

biotech and start-ups

• Raised >$100Mil

• MBA (UCLA), CPA (Arthur

Young)

Page 10: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 1010

ATI Consultants / Advisors

Alan Bennett, Ph.D.

Chair, SAB

• UC-Davis (Distinguished

Professor of Plant Science)

• Transformed/characterized

elite alfalfa with eIF-5A

• Runs advanced genetics lab

• B.S. (UC-Davis), Ph.D.

(Cornell)

Jerry Caulder, Ph.D.

Advisor

• Known as the “Father of

Agricultural Biotechnology”

• 15 years with Monsanto; as

CEO, built $1.2Bil valuation

• Lead 2 other companies,

Chair of Athenix, sold for

$400Mil. Founded Finistere

Ventures

• B.S. (SE Missouri State U.),

Ph.D. (U. Missouri)

Vaughn Smider, M.D., Ph.D.

Advisor

• CSO of Sevion Therapeutics,

Founder/President of precursor

company, Fabrus.

• Associate Professor at The

Scripps Research Institute

• Leadership Council for

American Cancer Society

• B.A (Hiram College), M.D. &

Ph.D. (Stanford U.)

Craig Williams

Field Trials / Regulatory

• 25 years experience

managing seed companies

• Knowledgeable in seed

business operations,

regulatory affairs, field

trials, M&A due diligence

• B.S. (Bradley U.)

Page 11: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 11

Opportunity for the Investor

• Seed round up to $950K in form of Convertible Notes with very favorable terms:

− Convertible into Series A round at 35% conversion discounts

− Annual 7% simple interest

− The Yield Lab & Dr. Feitelson lead investors

− Conversion pre-money valuation safeguards

• Goal for Preferred Stock Series A round of $3-5Mil (est.)

− Essentially plain vanilla

− Down round anti-dilution & participating upon dissolution

Page 12: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

12©2017 | www.agribodytech.com

Acquisition expected in 5 - 6 years

Strategic Trade Sale

• Every license/JV deal (forage, row, specialty

seed company) could generate a buyer

Private Equity

• Trait consolidation opportunities for yield

improvement

Goal:

Raise $1M Seed + $3-5M Series A over 2 yrs

↓>$60M Exit (15x cash-on-cash return)

Exit Strategy

Successful ag biotech platform exits:

• AgriQuest ($450M Sale/Bayer)

• DeVGeN ($523M Sale/Syngenta)

• Athenix ($400M Sale/Bayer)

• Divergence ($71M Sale/Monsanto)

• Ceres ($344M IPO)

• Evogene ($389M IPO)

Page 13: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

©2017 | www.agribodytech.com 1313

Summary

Join ATI in building

value by licensing &

co-developing ultra-

high yield, stress-

resistant crops with

established seed

companies

• CEO & Management TeamAg biotech entrepreneurs experienced,

resourceful, ethical

• Proof of Efficacy

• Broad IP

• Started alfalfa co-development

project & potato license

• License to Genome Editing & rapid

commercialization path

Page 14: Expanding Global Food Supply by Significantly Increasing ... · PDF fileExpanding Global Food Supply by Significantly Increasing Crop Yields Using ... − Foreign counterparts in

THANK YOU!Jerry Feitelson, Ph.D., Co-Founder & CEO

[email protected] | (858) 349-3603 | www.agribodytech.com