exovene: treatment of testicular cancer chylee martin and helaina lefler
DESCRIPTION
Potential Risks and Benefits Risks Hair loss Nausea/vomiting Dizziness Lower levels of testosterone or decreased sperm levels Benefits Treatment of cancer Reduce side effects, promote tumor shrinkage, completely eradicate testicular cancerTRANSCRIPT
Exovene: Treatment of Testicular CancerChylee Martin and Helaina Lefler
Population
• Young adult males between the ages of 18 and 40 who have been diagnosed with testicular cancer
Potential Risks and Benefits
• Risks• Hair loss• Nausea/vomiting• Dizziness• Lower levels of testosterone or decreased sperm levels
• Benefits• Treatment of cancer• Reduce side effects, promote tumor shrinkage, completely
eradicate testicular cancer
Description of Treatment
• Delivery method: ointment applied directly to testicles• The treatment will target cancerous cells of the testicles
that have increased metabolisms• The nanoparticles with competitive inhibitors for a
cellular respiration enzyme will attach to and enter the cells and their mitochondria
Description of Treatment
• Nanoparticles with competitive inhibitors will inhibit the hexokinase enzyme that catalyzes the phosphorylation of glucose, therefore inhibiting cellular respiration and metabolism
• The competitive inhibitor will bind to the hexokinase active site, therefore inhibiting cellular respiration• The cells will then die because they will be unable to make
ATP and will not be able to survive
Trial Objectives and Purpose
• Goals: to determine…• The efficacy of the treatment• Any side effects the treatment presents• Proper dosages
• Hypothesis: the Exovene treatment will successfully kill the cancerous cells by inhibiting cellular respiration and eradicate the testicular cancer
• This treatment is better than previous treatments because it can be applied directly to the affected area, will not affect any surrounding healthy cells, and will cause less discomfort for the patient.
Trial Design
• Double-Blind Trial• One randomized group of 50 patients will receive one
treatment, while the second randomized group of 50 patients will receive another treatment (based off strata of similar individuals)• Treatments will randomly be assigned to each group• One group receives Exovene treatment• The other group receives a placebo
Selection of Subjects
• Criteria:• Male• Must be within age group (21 to 40 years old)• Must be diagnosed with testicular cancer
Assessment of Safety
• Do not use except for the intended medical purpose• Do not allow anyone else to use the ointment• Use only on the patient’s testicles• Do not go over or under in dosage (use with proper
prescription)