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liinil1uili1111111 6864.493970 BLOSS: llllllllf Volume 13

THIRTIETH Annual Meeting of the

American Society of Clinical Oncology

May 14-17, 1994

PROGRAM/PROCEEDINGS Dallas, TX

Contents ASCO Program Information Officers and Directors .............................................................................................................................. iii Calendar of Events........................................................................... ............................... iv Committee Rosters............................. ............................................................................. vi General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Special Events................................................................................................................ x Educational Symposia................. ........... .......................................................................... xii Scientific Sessions...... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1

ASCO Proceedings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 AlDS ........................ .............. .. ................................................ .... ............................... 50 Breast Cancer................................................... ... ............................. ....................... ........ 56 Biomarkers and Diagnosis . . . . . . . . . . . . . . . . . .. . . . . .. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . .. . . . . . . . . . . . . . . . . . . . . . . 113 Cancer Biology and Molecular Genetics.............................................................................. 121 Clinical Pharmacology... ... .... ...... .. ...... ..... ............................................................ ...... ...... 131 Cancer Prevention and Cancer Control .. . . ... ..... . . ..... .. . . ... . ... . .. . ... . ... . . . .. . ... . .. . . .. . . . .. .. . .. .. . ... .. .. . .. 169 Central Nervous System Tumors........................................................................................ 174 Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 Endocrine Tumors........................................................................................................... 190 Gastrointestinal Tract Cancer ... . . . . . . . ... . . . . .. .. . . . . .. . . .. . . . . .... .. . . . . . . . .. . . . . . .. . .. . . . . . . .. . . . . . . . . . . . . . . .. . . . . . . . . 192 Genitourinary Tract Cancer.................... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229 Gynecological Tumors.................... ................................................................................. 256 Head and Neck Cancer.................................................................. ................................... 279 Tumor Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293 Leukemia, Adult. ................ .................................................... ... ..................................... 303 Leukemia, Pediatric......................................................................................................... 317 Lung Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325 Lymphoma, Adult................... ........................................................................................ 368 Lymphoma, Pediatric................... ................. ............................................... ...... .............. 392 Melanoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 394 Other Adult Solid Tumors... .. ................................................... ...... .. ................. .. .............. 401 Other Hematological Tumors . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 408 Pediatric Solid Tumors...... ... ...... .... .... .................... .......................................... ........ ....... . 413 Psychosocial Aspects of Cancer/Supportive Care............. .. .................................................... 428 Sarcomas........................................................................... .. ......................... .. .............. 473

Program/Proceedings Author Index . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . .. . . . . . . . . . . 483 Proceedings Subject Index... ......................... ...................................................... .. .. ......... ... 510

Volume 13 • March 1994

2 of 4 Celltrion, Inc., Exhibit 1019

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Program/Proceedings of the American Society of Clinical Oncology (

American Society of Clinical Oncology

Officers

1993-1994

President, George P. Canellos, M.D.

President-Elect, Karen H. Antman, M.D.

Immediate Past President, Bernard Fisher, M.D.

Secretary/Treasurer, Samuel G. Taylor IV, M.D.

Board of Directors

Joseph Aisner, M.D. Ross C. Donehower, M.D. Joseph S. Bailes, M.D. Charlotte D. Jacobs, M.D. Charles M. Balch, M.D. Brian J. Lewis, M.D. Clara D. Bloomfield, M.D. Allen S. Lichter, M.D. C. Norman Coleman, M.D. C. Kent Osborne, M.D.

Nicholas J. Vogelzang, M.D.

Robert E. Becker, JD, CAE Executive Director

Michael C. Perry, M.D., Editor

Editorial Staff provided by W.B. Saunders Company

Copyright e 1994 by the American Society of Clinical Oncology

Ill

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3 of 4 Celltrion, Inc., Exhibit 1019

BREAST CANCER

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