exercise training and cardiac rehabilitation › dtmhf_support › taub_2.pdfpatient outcomes with...
TRANSCRIPT
![Page 1: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/1.jpg)
Exercise Training and Cardiac
Rehabilitation
Pam R. Taub MD, FACC
Founder and Director of Step Family Cardiac Wellness
and Rehabilitation Center
Associate Professor of Medicine
UC San Diego Health
![Page 2: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/2.jpg)
Disclosures
No conflict of interest related to topics discussed in this talk
![Page 3: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/3.jpg)
Overview of Talk
• Review of current state of cardiac rehabilitation
• New paradigms in Cardiac Rehabilitation
• Overview of our program at UCSD
• Review of Outcomes at UCSD Cardiac Rehabilitation Program
![Page 4: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/4.jpg)
Overview of Cardiac Rehabilitation Programs
72 sessions over 9 weeks
![Page 5: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/5.jpg)
Currently Covered Indications for Cardiac Rehabilitation
▪ Heart attack
▪ Coronary artery bypass grafting (CABG)
▪ Chronic stable angina
▪ Cardiac transplantation
▪ Heart valve repair or replacement
▪ Stable, chronic heart failure (EF<35%)
▪ Peripheral Arterial Disease
![Page 6: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/6.jpg)
Depression & Psychosocial Stress Post MI
• Major depression occurs in 20% patients post MI; depressive symptoms in 33%
• Associated with poor compliance
• Increased adverse outcomes and higher cardiac mortality
• Increased risk of suicide
• Several nonrandomized studies have shown a benefit with stress reduction and enhanced social support post-MI
• Cardiac rehabilitation (which includes stress management and group therapy) is an important tool in treating depression after MI
.
Lecture: Coronary Artery Disease: Acute Coronary Syndromes & Post MI Depression
![Page 7: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/7.jpg)
Outcomes Associated with Cardiac Rehabilitation
▪ Meta-analysis of 34 randomized controlled trials
showed that exercise-based CR programs are
associated with:• A lower risk of re-infarction (OR 0.53; 95% CI: 0.38 to 0.76)
• Decreased cardiac mortality (OR 0.64; 95% CI: 0.46 to 0.88)
• Decreased all-cause mortality (OR 0.74; 95% CI: 0.58 to 0.95)
▪ CR reduces 90 day hospital readmission rate after
acute MI or PCI
▪ Class IA recommendation by AHA/ACC Guidelines
Am J Med 2004;116:682–92.
![Page 8: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/8.jpg)
![Page 9: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/9.jpg)
![Page 10: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/10.jpg)
![Page 11: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/11.jpg)
![Page 12: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/12.jpg)
![Page 13: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/13.jpg)
13
![Page 14: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/14.jpg)
Lifestyle Heart Trial
% Diameter Stenosis: Quantitative Coronary Arteriography
Ornish D et al. Lancet. 1990; 336:129 & JAMA. 1998;280:2001.
![Page 15: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/15.jpg)
Case study of a patient from enrolled in Intensive Cardiac Rehabilitation Program
![Page 16: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/16.jpg)
New Approaches to Cardiac Rehab
![Page 17: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/17.jpg)
17
Assessment of Visceral Fat
![Page 18: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/18.jpg)
![Page 19: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/19.jpg)
Patient Outcomes with Intensive Cardiac RehabilitationBaseline Post
Hemoglobin A1c:
Goal: < 5 – 75.1 4.9
CRP:
Goal: < 0.5 0.3 0.3
Total Cholesterol: 144 126
LDL:
Goal: < 70 55 47
HDL:
Goal: > 40 70 73
Triglycerides:
Goal: < 15096 88
Cholesterol/HDL Ratio: 2.06 2.07
Visceral Fat:
Goal: < 1010 8
Body Fat: 39.3 37.3
Waist Circumference:
Goal: <40 Men
<35 Women
39 32
METS:
Goal: 2 MET increase from
baseline
4.5 9
Weight: 155.6 142.8
Muscle Mass %: 57.6 59.5
![Page 20: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/20.jpg)
OBJECTIVES
• To evaluate the effectiveness of intensive cardiac rehabilitation
(ICR) for improving clinical outcomes and biomarkers
• To compare the effectiveness of TCR and ICR programs for
improving clinical outcomes and biomarkers
• To evaluate the effectiveness of traditional cardiac rehabilitation
(TCR) for improving clinical outcomes and biomarkers
![Page 21: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/21.jpg)
METHODS
• Retrospective review of numerous biomarkers data pre- and post- participation in CR
programs in the hospital databases
• Retrospective review of longitudinal clinical outcome data (including major adverse
cardiac events, MACE) in the long-term follow-up in the hospital databases
• Inclusion criteria for the analysis: patients who participated in the CR program and
have data available to review
• Comparative analysis of clinical outcomes and biomarkers between the groups of
patients participating in the TCR and ICR programs
• Paired t-test was used for testing equality of means of continuous parameters within
the ICR and TCR groups. Repeated Measure Analysis of Variance (RM-ANOVA) was
used for testing differences between the groups. Demographic and clinical parameters
were tested with analysis of variance (ANOVA) for continuous variables and chi-
square analysis for dichotomous variables.
![Page 22: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/22.jpg)
RESULTS
• 101 patients were enrolled in the intensive cardiac rehabilitation (ICR)
program
• Treatment adherence: 66.3% of sessions attended in the TCR
program and 95.8% of sessions in the ICR program
• 216 patients were enrolled in the traditional cardiac rehabilitation
(TCR) program
• Mean long-term follow-up: 6.7 months in the TCR program and 7.8
months in the ICR program (p = 0.023)
• Enrollment in the study: in total 317 patients
![Page 23: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/23.jpg)
RESULTS
DEMOGRAPHIC CHARACTERISTICS
Variable ICR TCR p value
Age (years) 66.0 65.6 ns
Gender: male (%) 68 73 ns
Gender: female (%) 32 27 ns
Race: white (%) 76 72 ns
Post-menopausal females (%) 100 90 ns
ns - difference between the groups is not significant
![Page 24: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/24.jpg)
Weight
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht
ch
an
ge
[
kg
]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
p < 0.001
p < 0.001
![Page 25: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/25.jpg)
Body mass index (BMI)
Difference within the groups Difference between the groups
BM
I [
kg m
-2 ]
27.0
27.2
27.4
27.6
27.8
28.0
28.2
28.4
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeB
MI
ch
an
ge
[
kg
m-2
]
-1.2
-1.0
-0.8
-0.6
-0.4
-0.2
0.0
0.2
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
p < 0.001
p < 0.001
![Page 26: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/26.jpg)
Body fat
Difference within the groups Difference between the groups
Body fat
[ %
]
29.0
29.5
30.0
30.5
31.0
31.5
32.0
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
*
Bo
dy f
at
ch
ang
e
[ %
]
-2.5
-2.0
-1.5
-1.0
-0.5
0.0
0.5
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
p < 0.001 p = 0.002
p = 0.046
![Page 27: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/27.jpg)
Visceral fat
Difference within the groups Difference between the groups
Vis
cera
l fa
t [
% ]
10.0
10.5
11.0
11.5
12.0
12.5
13.0
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
*
Vis
cera
l fa
t change [ %
]
-2.0
-1.5
-1.0
-0.5
0.0
0.5
ICR TCR
discharge - initial discharge - initial
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
p = 0.001
p < 0.001
![Page 28: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/28.jpg)
Waist circumference
Difference within the groups Difference between the groups
Wa
ist
[ c
m ]
95
96
97
98
99
100
101
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
*
Wa
ist
ch
an
ge
[
cm
]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
p < 0.001
p = 0.002
p = 0.002
![Page 29: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/29.jpg)
RESULTS - SUMMARY
• TCR program resulted in improvements of body fat, visceral fat,
and waist circumference
• ICR program resulted in improvements of weight, BMI, body fat,
visceral fat, and waist circumference
• Compared with TCR, the ICR program resulted in more significant
improvements of weight, BMI, body fat, and waist circumference
METABOLIC BIOMARKERS
![Page 30: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/30.jpg)
Metabolic equivalents (METS)
Difference within the groups Difference between the groups
ME
TS
[
mLO
2 k
g-1
min
-1 ]
3
4
5
6
7
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
*
ME
TS
ch
an
ge
[
mLO
2 k
g-1
min
-1 ]
0.0
0.5
1.0
1.5
2.0
2.5
ICR TCR
discharge - initial discharge - initial
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
p < 0.001
p < 0.001
![Page 31: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/31.jpg)
Systolic blood pressure (SBP)
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
SB
P
[ m
m H
g ]
114
116
118
120
122
124
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeS
BP
ch
an
ge
[
mm
Hg ]
-6
-5
-4
-3
-2
-1
0
ICR TCR
discharge - initial discharge - initial
p = 0.001
![Page 32: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/32.jpg)
Diastolic blood pressure (DBP)
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
DB
P c
hange [ m
m H
g ]
-8
-6
-4
-2
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
SB
P [
mm
Hg ]
60
62
64
66
68
70
72
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
p < 0.001
p < 0.001
![Page 33: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/33.jpg)
Heart rate (HR)
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
dischargeW
eig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
HR
[
bpm
]
66
68
70
72
74
76
ICR TCR
*
difference is statistically significant
initial
discharge
initial
dischargeH
R c
ha
ng
e
[ b
pm
]
-0.5
0.0
0.5
1.0
1.5
2.0
2.5
ICR TCR
*
difference is statistically significant
discharge - initial discharge - initial
p = 0.007
p = 0.05
![Page 34: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/34.jpg)
RESULTS - SUMMARY
• TCR program resulted in improvement of METS
• ICR program resulted in improvements of METS, SBP, and DBP
• Compared with TCR, the ICR program resulted in more significant
improvements of DBP and HR
HEMODYNAMIC PARAMETERS
![Page 35: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/35.jpg)
Low-density lipoprotein cholesterol (LDL-C)
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initialL
DL
-C c
han
ge
[
mg
dL
-1 ]
-10
-8
-6
-4
-2
0
ICR TCR
discharge - initial discharge - initial
LD
L-C
[
mg d
L-1
]
60
65
70
75
80
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
p = 0.006
![Page 36: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/36.jpg)
Non-high-density lipoprotein cholesterol (Non-HDL-C)
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initialN
on
-HD
L-C
ch
an
ge
[
mg d
L-1
]
-14
-12
-10
-8
-6
-4
-2
0
ICR TCR
discharge - initial discharge - initial
No
n-H
DL
-C
[ m
g d
L-1
]
80
85
90
95
100
105
110
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
p = 0.001
![Page 37: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/37.jpg)
Triglycerides (TG)
Difference within the groups Difference between the groups
Weig
ht [
kg ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
We
ight
[ k
g ]
80
81
82
83
84
85
ICR TCR
*
*difference is statistically significant
initial
discharge
initial
discharge
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
Weig
ht change [ kg ]
-3
-2
-1
0
ICR TCR
*
*difference is statistically significant
discharge - initial discharge - initial
TG
[
mg
dL
-1 ]
110
115
120
125
130
135
ICR TCR
initial
discharge
initial
dischargeT
G c
han
ge
[
mg d
L-1
]
-10
-8
-6
-4
-2
0
ICR TCR
discharge - initial discharge - initial
![Page 38: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/38.jpg)
RESULTS
CLINICAL OUTCOMES IN LONG-TERM FOLLOW-UP
MACE ICR TCR p value
Death n (%) 1 (1) 6 (2.8) ns
Cardiovascular death n (%) 1 (1) 3 (1.4) ns
Non-fatal myocardial infarction n (%) 1 (1) 3 (1.4) ns
Hospitalization for unstable angina n (%) 3 (3) 3 (1.4) ns
PCI n (%) 2 (2) 2 (0.9) ns
CABG n (%) 0 (0) 1 (0.5) ns
Hospitalization for heart failure n (%) 2 (2) 9 (4.2) ns
PAD intervention n (%) 0 (0) 2 (0.9) ns
Both CR programs resulted in a decrease of incidence of angina. After ICR the incidence
of angina was 5%, and after TCR 6% (ns between the groups).
![Page 39: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/39.jpg)
SUMMARY
• A trend towards lower incidence of adverse clinical outcomes in the long-term
follow-up in the ICR group vs. TCR group with low readmission rates for heart
failure was observed
• We are conducting further studies with a larger patient population and a longer
follow-up for the assessment of the effectiveness of the ICR program
• Compared with TCR, the ICR program resulted in more significant
improvements of metabolic biomarkers (weight, BMI, body fat, and waist
circumference), hemodynamic parameters (DBP and HR), and lipid biomarkers
(TC, LDL-C, and Non-HDL-C)
• Our results emphasize the importance of a comprehensive lifestyle approach
going beyond exercise for improving biomarkers and clinical outcomes
![Page 40: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/40.jpg)
40
![Page 41: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/41.jpg)
Conclusions
▪ Lifestyle approaches such as cardiac rehabilitation can decrease CV risk.
▪ These strategies are synergistic with device and pharmacotherapy.
▪ New era in preventive cardiology ushered in by shift to value based care.
![Page 42: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/42.jpg)
42
![Page 43: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/43.jpg)
![Page 44: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/44.jpg)
![Page 45: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/45.jpg)
![Page 46: Exercise Training and Cardiac Rehabilitation › dtmhf_support › Taub_2.pdfPatient Outcomes with Intensive Cardiac Rehabilitation Baseline Post Hemoglobin A1c: Goal: < 5 –7](https://reader034.vdocuments.us/reader034/viewer/2022042314/5f02fc587e708231d406f9e1/html5/thumbnails/46.jpg)