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TRANSCRIPT
Excellent performance
Persistence and highest quality
Wide range of product line
Abundant accumulation of technologyand experience
spherical and sharp particle size distribution
offeres packing materials and packed columns,under strict quality control
MCI GEL™ has been designed based on technology of the world famous Diaion™ and Sepabeads™,
specialized in polymeric packing materials includingfrom analytical to preparative use,
for ion exchange, reversed-phase mode
for more than 50 years, MCI GEL™ has been used for HPLC applications
Sugars・Sugar alcohols・Organic acids《CK08,06 series》Examples of peak retention time 《CK08E series》Oligosaccharides 《CK04S・CK04SS・CK02A・CK02AS》Amino acids《CK10U》Sugars・Organic acids 《CA08F》Nucleic acids etc. ・Sugars・Human urine 《CDR10》
Bioseparation columnsIon exchange chromatography column《XtalSpeedTM》
Rituxan《XtalSpeedTM》Column list and materials[Applications]
Size exclusion chromatography columnsAqueous size exclusion columns 《CQP series》
Column list and materials[Applications]Calibration curves 《CQP series》
Proteins・Water soluble polymers 《CQP series》
Separation mechanism of CHP seriesPolymeric partition chromatography columns and materials MCI GELTM CHP series
Solid phase extraction sorbents
Column listColumn durability[Applications] Organic compounds・Insulin・Peptide 《CHP column series》
Polymeric chromatography materials 《CHP material series》Chromatography material list[Applications] Organic compounds 《CHP material series》
Synthetic adsorbents and reversed-phase material listChelating type list
Column selection guide
Ion exchange columns and materials
Ion chromatography columns and materials
Bioseparation columns and materials
Analytical and preparative chromatography columns and materials for pharmaceutical applications
Chiral separation columns
MCI GEL™ material list
MCI GEL™ column list
Compounds index
Column list and materials[Applications]
Features
Column list and materials[Applications]Cations 《SCK01》
Cations 《CHK45》Anions 《SCA04》
Separation mechanism of CRS series
Separation conditions for various amino acids[Applications] Optical isomers 《CRS10W・CRS15W》
5
1
6
10
9
8
5
4
3
2 5~22
28~32
567~121314~1617~1819~2021~22
USP list 3
2829~30293031~3231313232
3333343536~48
606060
49~564950~53
5455~5859
33~53
54~59
61~62
SPE sorbent series7 60
63~66
67~75
23~2723~2424~252526~27
3~4
1 2
�R�e�v�e�r�s�e�d�-� �P�h�a�s�e
�I�o�n� �E�x�c�h�a�n�g�e
�R�e�v�e�r�s�e�d�-� �P�h�a�s�e
�S�i�z�e� �E�x�c�l�u�s�i�o�n
�I�o�n� �E�x�c�l�u�s�i�o�n
�I�o�n�C�h�r�o�m�a�t�o�g�r�a�p�h�y
�S�i�z�e� �E�x�c�l�u�s�i�o�n
�M�.�W�.�<�2�,�0�0�0
�M�.�W�.�>�2�,�0�0�0
�W�a�t�e�r�S�o�l�u�b�l�e
�O�r�g�a�n�i�c�S�o�l�v�e�n�t�S�o�l�u�b�l�e
�S�a�m�p�l�e
�L�i�g�a�n�d� �E�x�c�h�a�n�g�e
�R�e�v�e�r�s�e�d�-� �P�h�a�s�e
�M�i�x� �m�o�d�e
�N�o�r�m�a�l� � �P�h�a�s�e
�M�i�x� �m�o�d�e
�I�o�n� �E�x�c�l�u�s�i�o�n
33~53
14~16
14~16
31~32
17~ 1819~22
21~22
31~32
29~31
33~53
23~27
7~1354~59
34,45~48
33~53
33~53
23~25
33~53
33~53
34,45,48
7,11~12
CK02A CK02AS
CK04S CK04SS
CQP06
CK10U
CDR10
CA08F CDR10
CQP10 CQP30
XtalSpeedTM
CMG20CHPODCHP20 CHP07
SCA04
CMG20 CHPOD
SCK01CHK45
CMG20CHPODCHP20CHP07
CHK40CHK45
CHP20 CMG20CHP07
CK08E SeriesCRS10W CRS15W
CHK40CHK45
CK08EH
Column selection guide
�N�a�t�u�r�e� �o�f� �s�a�m�p�l�e �S�e�p�a�r�a�t�i�o�n�m�o�d�e
�M�C�I� �G�E�L�™
�c�o�l�u�m�n �p�H� �r�a�n�g�e �A�p�p�l�i�c�a�t�i�o�n�s �P�a�g�e�s
1 Column selection guide
(α�-�a�m�i�n�o� �a�c�i�d�s・� � � � α�-�h�y�d�r�o�x�y� �c�a�r�b�o�x�y�l�i�c� �a�c�i�d�s�)
�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s
�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s
�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s
Full range
Full range
Full range
Full range
Full range
�P�e�p�t�i�d�e�s
1 ~ 7
6 ~ 7
6 ~ 7
2 ~12
1 ~141 ~13
1 ~13
2 ~12
2 ~12
2 ~12
5 ~ 7
2 ~12
3 ~ 71.5~12
2 ~12
1 ~ 7
�O�l�i�g�o�s�a�c�c�a�r�i�d�e�s
�O�l�i�g�o�s�a�c�c�a�r�i�d�e�s
�A�m�i�n�o� �a�c�i�d�s�O�r�g�a�n�i�c� �a�c�i�d�s�S�a�c�c�h�a�r�r�i�d�e�s
�N�u�c�l�e�o�t�i�d�e�s
�P�r�o�t�e�i�n�s�,�B�i�o�p�o�l�y�m�e�r�s� �W�a�t�e�r� �s�o�l�u�b�l�e� �p�o�l�y�m�e�r�s
�P�r�o�t�e�i�n�s�,�A�n�t�i�b�o�d�y
�P�r�o�t�e�i�n�s�,�P�e�p�t�i�d�e�s
�P�r�o�t�e�i�n�s�,�P�e�p�t�i�d�e�s
�A�n�i�o�n�s
�A�m�i�n�o� �a�c�i�d�s�,� �N�u�c�l�e�t�i�d�e
�O�p�t�i�c�a�l� �i�s�o�m�e�r�s�S�a�c�c�h�a�r�r�i�d�e�s
�C�a�t�i�o�n�s
�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s�p�e�p�t�i�d�e�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s�p�e�p�t�i�d�e
�O�r�g�a�n�i�c� �a�d�i�d�s
●USP LISTING OF MCI GELTM
●Product list by particle size and separation mode
USP Code
L17
L19
L21
L25
L31
L32
L37
L38
L39
L58
CK08EH
CK08EC
CHP20/C04CHP20/C10
CQP06
SCA04
CRS10WCRS15W
CQP30
CQP10CQP30CMG20/C04CMG20/C10CK08SCK08ECK04SCK02A
PACKING MCI GELTM
Column Page
Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the hydrogen form, 6 to 12 µm in diameter
Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the calcium form, 5 – 15 µm in diameter
A rigid, spherical styrene-divinylbenzene copolymer, 3 to 30 µm in diameter
Packing having the capacity to separate compounds with a molecular weight range from 100-5000 (as determined by polyethylene oxide), applied to neutral, anionic, and cationic water-soluble polymers. A polymethacrylate resin base, cross-linked with polyhydroxylated ether (surface contained some residual carboxyl functional groups) was found suitable
A hydroxide-selective, strong anion-exchange resin-quaternary amine bonded on latex particles attached to a core of 8.5-µm macroporous particles having a pore size of 2000 Ǻ units and consisting of ethylvinylbenzene cross-linked with 55% divinylbenzene
A chiral ligand-exchange resin packing-L-proline copper complex covalently bonded to irregularly shaped silica particles, 5 to 10 µm in diameter
Packing having the capacity to separate proteins by molecular size over a range of 2,000 to 40,000 Da. It is a polymethacrylate gel
A methacrylate-based size-exclusion packing for water-soluble samples
A hydrophilic polyhydroxymethacrylate gel of totally porous spherical resin
Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the sodium form, about 6 to 30 µm diameter
5
CK CK
CDR10
CQA_PCQK_P
XtalSpeedTM
CHK40CHK45
CK CKCA CA CA CA
CK
10 30 50 150
Analytical Preparative
CHK45SCA
SCK
CQP
CRS
CHP20/P20 CHP20/P30 CHP20/P50 CHP20/P120CHP20/P70CHP20/C04 CHP20/C10
CHPOD/P30CHPOD/C04
CMG20/C04 CMG20/C10CMG20/P10 CMG20/P30 CMG20/P150
CHP85/P120CHP87/P120
CHP07/C04 CHP07/C10 CHP07/P120
CHP50/P20 CHP50/P30CSP50/P10
Particle size[μm]Separation
mode
Ion exchange
Ion chromatography
Normal phase
Size exclusion
Mix mode
Ligand exchange
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9
10
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3
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10
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10
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10
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8
9
10
1
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5
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9
10
1
2
3
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9 9
10
1
2
3
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6
10 10
1
2
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5
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8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
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カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
3 4
●Description of a gel type ion exchange column
MCI GEL™ CK08ECfor HPLC use
Cation=KAnion=A
DVB%
Counter ion
Particle size(mode)
no letter=Na+, C=Ca2+S=Ag+, H=H+
A=20μm, S=11μmE=9μm, F=7μm,U=5μm
●Note ; Pre-column and guard column
●MCI GEL™ columns for HPLC
Please consider using a guard column concerning purity of injection sample. Guard columns, are listed in the end of this catalog, should be selected in accordance with a main column.
As for analysis of amino acids by MCI GEL™ CK10U, MCI GEL™ AFR2-PC is recom-mended as a pre-column. The AFR2-PC column is very effective to stabilize base line because it can trap ammonium ion in eluent. A peak caused of the ammonium ion may disturb base line stability.
2.
1.
Typical usageDescription
Product nameColumn
dimensionsI.D�L[mm]
10
8
8
8
8
8
4
4
2
2
8
Highporous
5
11
9
9
9
9
11
11
20
20
7
7
Na+
Na+
Na+
Ca2+
Ag+
H+
Na+
Ag+
Na+
Ag+
SO24-
AcO-
L58
6 11Ca+
L58
L19
L17
L58
L58
6�120
8�500
7.8�300
7.8�300
8�300
7.8�300
8.0�300
8.0�300
8.0�300
10�200
10�200
20�250
20�250
4.6�250
4.6�250
MCI GEL™ CK04S
MCI GEL™ CK04SS
MCI GEL™ CK02A
MCI GEL™ CK02AS
MCI GEL™ CA08F
MCI GEL™ CDR10
MCI GEL™ CK10U
MCI GEL™ CK08S
8�500MCI GEL™ CK06SC
MCI GEL™ CK08E
MCI GEL™ CK08EC
MCI GEL™ CK08ES
MCI GEL™ CK08EH
MCI GEL ™Anion
exchange columnsM
CI G
EL™ C
ation exchange columns
Aminoacid
Monosaccharide
Oligo-saccharide
Carboxylicacid
Amine Physiologicalfluid
Packing materialCross
linkage[%]
Particlesize[μm]
Counterion
USP
●Packing materials Packing materials are available. Please look at P.64 and P.65.
Features
Ion exchange columns and materials
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�I�o�n� �e�x�c�h�a�n�g�e� �r�e�s�i�n�s� �a�r�e� �g�e�n�e�r�a�l�l�y� �u�s�e�d� �f�o�r� �a�n�a�l�y�s�i�s� �o�f� �a�m�i�n�o� �a�c�i�d�s�,� �s�u�g�a�r�s�,� �o�r�g�a�n�i�c� �a�c�i�d�s� �a�n�d� �a�m�i�n�e�s�,� �e�t�c�.� �M�C�I� �G�E�L�™� �c�u�s�t�o�m� �p�r�e�-�p�a�c�k�e�d� �c�o�l�u�m�n�s� �a�r�e� �s�p�e�c�i�f�i�c�a�l�l�y� �d�e�s�i�g�n�e�d� �f�o�r� �e�a�c�h� �a�p�p�l�i�c�a�t�i�o�n� �u�s�i�n�g� �t�h�e� �m�o�s�t� �a�p�p�r�o�p�r�i�a�t�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �a�m�o�n�g� �o�u�r� �p�r�o�d�u�c�t� �l�i�n�e� �a�n�d� �u�s�i�n�g� �t�h�e� �m�o�s�t� �s�u�i�t�a�b�l�e� �c�o�l�u�m�n� �d�i�m�e�n�s�i�o�n�s�.�T�y�p�i�c�a�l� �a�p�p�l�i�c�a�t�i�o�n� �f�o�r� �e�a�c�h� �c�o�l�u�m�n� �i�s� �s�h�o�w�n� �i�n� �t�h�i�s� �c�a�t�a�l�o�g�.� �T�h�e�s�e� �d�a�t�a� �w�i�l�l� �s�u�g�g�e�s�t� �a�n� �a�p�p�r�o�p�r�i�a�t�e� �c�o�l�u�m�n�.
Mitsubishi Chemical Ion Exchange Resins
1. Variety of products
2. Persistence of high quality, excellent separation performance
3. Accumulation of abundant knowledge and experience of applications
●Chemical structure of ion exchange resin〈Strongly acidic cation exchange resin〉 〈Strongly basic anion exchange resin〉
MCI GEL™ CK series○Cation exchange resins
○Anion exchange resinsMCI GEL™ CA series
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2 Ion exchange columns and materials
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MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
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カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
5 6
Cation exchange columnsapplications; sugars, carboxylic acids, (poly)alcohols, etc.CK08,06 series Cation exchange columnsapplications; sugars, carboxylic acids, (poly)alcohols, etc.
2
CK08EC 8×300, 7.8×300 CK08EH 8×300, 7.8×300
Application data of CK08ECFig. 2-1 Sugars Fig. 2-2 Apple juice
●Column list
MCI GEL™ column Counter ion
MCI GEL™ CK08SMCI GEL™ CK08E Na+
MCI GEL™ CK08EC Ca2+
MCI GEL™ CK08ES Ag+
MCI GEL™ CK06SC Ca2+
USP
L58
L17
L19
Application areas
General sugar separation columns
The most general sugar separation columnHighly recommended for fructose and glucoseThis column conforms to US Pharmacopeia.
Gel permeation chromatographic effect
Use for analysis of mono-saccharides and disaccharides.
MCI GEL™ CK08EH H+ Organic acids with H3PO4 eluent; sugars with distilled water eluent
:MCI GEL™ CK08EC 8mm I.D.×300mm:H2O:0.6:75℃:RI
Fig. 2-3 Lactulose syrup
min.0 10 20 30 min. min.0 10 20 30 0 4 8 12 16 20 24 28
Sorb
itol
Rib
ose
Fruc
tose
Fruc
tose
Salic
inM
anni
tol
Adon
itol
mes
o-Er
ythr
itol
Man
nose
Glu
cose
Lact
ose
Gen
tiobi
ose
Stac
hyos
e
Xylit
ol
Glu
cose
Sucr
ose
Lact
ose
Lact
ulos
e
Gal
acto
seConditionsColumn
EluentFlow rateColumn temp.Detection
Application data of CK08EC
Fig. 2-4 Sports drink A
:MCI GEL™ CK08EC 8mm I.D.×300mm:H2O:0.6:75℃:RI
Fig. 2-5 Sports drink B Fig. 2-6 Honey
Fig. 2-7 Jam Fig. 2-8 Sugars/Alcohols
Sucr
ose
Sucr
ose
Glu
cose
Glu
cose
Glu
cose
Fruc
tose
Fruc
tose
Fruc
tose
Dp
3
Dp
2
Dp
2
min.0 10 20 min.0 10 20 min.0 10 20
Glu
cose
Glu
cose
Fruc
tose Fr
ucto
se
Ethy
l alc
ohol
Man
nito
l
min.0 10 20 min.0 10 20Er
ythr
itol
Gly
cero
l
ConditionsColumn
EluentFlow rateColumn temp.Detection
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MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
7 8
Application data of CK08EC
D-(+)-Glucose D-(-)-Fructose meso-ErythritolGlycerolEthanolD-Mannitol
Results:
Pressure: 28Bar (Including system pressure)
Rt RsAsTPN11.39 14.39 16.59 17.31 18.18 18.83
2085 2597
16899 19051 37357 12885
-2.892.661.402.121.33
1.07 0.97 0.84 0.95 0.80 1.00
D-(+)-Glucose D-(-)-Fructose meso-ErythritolGlycerolEthanolD-Mannitol
Results:
Pressure: 38Bar (Including system pressure)
Rt RsAsTPN10.2513.3715.6316.3216.7317.99
15092210
15833216083552510387
-2.932.781.501.142.43
1.120.980.900.951.690.96
Stachyose hydrateβ-Gentiobioseα-Lactose monohydrateD-(+)-GlucoseD-(+)-MannoseD-(-)-FructoseRibitol (Adonitol)meso-ErythritolD-MannitolD-(-)-SalicinXylitolD-(-)-Ribose
123456789
101112
Results:
Pressure: 28Bar (Including system pressure)
Rt RsAsTPN8.259.139.83
11.2712.9014.3215.7816.5018.7319.6922.6623.75
511155043024200233502713
1541017734130444104
139652278
-1.861.221.771.761.471.851.433.901.083.090.86
1.040.971.191.091.011.010.840.990.871.350.882.09
Stachyose hydrateβ-Gentiobioseα-Lactose monohydrateD-(+)-GlucoseD-(+)-MannoseD-(-)-FructoseRibitol (Adonitol)meso-ErythritolD-(-)-SalicinD-MannitolXylitolD-(-)-Ribose
123456789
101112
Results:
Pressure: 39Bar (Including system pressure)
Rt RsAsTPN7.218.028.76
10.2311.7813.2714.7615.5116.8617.8821.9022.87
424343972249144128302188
13744160053594
12043132352381
-1.781.281.731.631.511.861.501.791.235.720.86
1.071.011.141.061.031.000.921.010.881.070.943.00
D-(+
)-Glu
cose
D-(-
)-Fru
ctos
e
Etha
nol
Gly
cero
l
mes
o-Er
ythr
itol
D-M
anni
tol
D-(+
)-Glu
cose
D-(-
)-Fru
ctos
e
Etha
nolGly
cero
lm
eso-
Eryt
hrito
l
D-M
anni
tol
0 5 10 15 min20 25 300 5 10 15 min20 25 30
1 2
3
4 5
6
7
8
9
10
11
12
12
3
45
6
7
8
9
10
11
12
0 5 10 15 min20 25 30 0 5 10 15 min20 25 30
① MCI GELTM CK08EC (7.8�300mm) ② Competitor’s Column
① MCI GELTM CK08EC (7.8�300mm) ② Competitor’s Column
Fig. 2-9 Sugars/Alcoles(Comparison with competitor’s column)
Fig. 2-10 Sugars(Comparison with competitor’s column)
:7.8x 300 mmI.D. (MCI GEL™ CK08EC / Competitor’s Column )
:20μL:40mmol/ml each
:Milli Q water:0.6:75 ℃
ConditionsColumnEluent Flow rateTemperatureSample ConcInjection
:7.8x 300 mmI.D. (MCI GEL™ CK08EC / Competitor’s Column )
:20μL:40mmol/ml each
:Milli Q water:0.6:75 ℃
ConditionsColumnEluent Flow rateTemperatureSample ConcInjection
RI (
mV)
RI (
mV)
RI (
mV)
RI (
mV)
Application data of CK08EC
Application data of CK08E
Fig. 2-12 Maltose syrup powder
① Maltose syrup powder ② Mixture
Fig. 2-11 Analysis of galoctose impurity
ConditionsColumn EluentFlow rateTempSample
Injection
:MCI GEL™ CK08E 7.8mm I.D.×300mm:Milli Q water:0.4:50℃:
:5μl.
1.Maltotoriose2.Maltose3.Glucose
:MCI GEL™ CK08EC 7.8mm I.D.×300mm:Milli Q water:0.6:85℃
ConditionsColumn EluentFlow rateTemp
2016128 min40 2016128 min40
① Galactose / Fructose = 0.1 / 99.9 ② Galactose / Sucrose = 0.1 / 99.9
2016128 min40
Fructose
Galactose
2016128 min40
Sucrose
Galactose
1.M
alto
torio
se 1.M
alto
torio
se
2.M
alto
se
2.M
alto
se
3.G
luco
se
3.G
luco
se
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
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10
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3
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6
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9
10
1
2
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8
9
10
1
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3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
9 10
Application data of CK08EH
Tric
hlor
oace
tic a
cid
4 20 min.8 12 16
Dic
hlor
oace
tic a
cid
Acet
ic a
cid
Chl
oroa
cetic
aci
d
Gly
colic
aci
d
10 20 min.
Dic
hlor
oace
tic a
cid
Acet
ic a
cid
Chl
oroa
cetic
aci
d
Ethy
lene
gly
col
Die
thyl
ene
glyc
olTr
ieth
ylen
e gl
ycol
10 20 min.
Fig. 2-19 Lactose
Lact
ose
Lact
ulos
e
Gal
acto
se
Fig. 2-17 Poly alcohols
:MCI GEL™ CK08EH 8mm I.D.×300mm:1% H3PO4
:0.6:25℃:RI
ConditionsColumn
EluentFlow rateColumn temp.Detection
:MCI GEL™ CK06SC 8mm I.D.×500mm:H2O :1.0:75℃:RI:20μL
ConditionsColumn
EluentFlow rateColumn temp.DetectionInjection volume
:MCI GEL™ CK08EH 8mm I.D.×300mm:2% H3PO4
:0.6:ambient:210nm
Fig. 2-18 Carboxylic acids
ConditionsColumn
EluentFlow rateColumn temp.Detection
Fig. 2-16 Chloroacetic acids
:MCI GEL™ CK08EH 8mm I.D.×300mm:1% H3PO4
:0.6:45℃:210nm
ConditionsColumn
EluentFlow rateColumn temp.Detection
Application data of CK06SC
4 8 12
Application data of CK08EH
Fig. 2-13 Carboxylic acids Fig. 2-14 Amino sugars
40
Acet
ic a
cid
Form
ic a
cid
Lact
ic a
cid
Gly
colic
aci
dM
alon
ic a
cid
Mal
ic a
cid
Tarta
ric a
cid
Citr
ic a
cid
Oxa
lic a
cid
min.8 12 16 20 24 min.0 10G
luco
se
N-A
cety
lglu
cosa
min
eN
-Ace
tylg
alac
tosa
min
e20
ConditionsColumn EluentFlow rateColumn temp.Detection
:MCI GEL™ CK08EH, 8mm I.D.×300mm:1% H3PO4(Fig.2-13,2-14):0.6:45℃(Fig. 2-13), ambient(Fig. 2-14):210nm(Fig. 2-13), RI(Fig. 2-14)
Fig. 2-15 Alcohols
:MCI GEL™ CK08EH, 7.8mm I.D.×300mm:60 ℃:2.5 bar:RI:10.0 μL
ConditionsColumn TempPressDetectionInjection
10 20 30 40 50 10 20 30 40 50
Other company's columnMCI GEL™ CK08EH
glyc
erol
Ethy
lene
Gly
col
MeO
H EtO
Hi-P
rOH
n-Pr
OH
sec-
BuO
H
n-Bu
OH
MeO
H EtO
Hi-P
rOH
n-Pr
OH
sec-
BuO
H
n-Bu
OH
glyc
erol
Ethy
lene
Gly
col
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
11 12
CK02A 20×250 CK04S 10×200 CK04SS 10×200
Cation exchange columnsapplications; oligosaccharides
Calibration curves of malto-oligosaccharides
CK04S, CK04SSCK02A, CK02AS
Cation exchange columnsapplications; oligosaccharides
Fig. 2-20
�T�h�e� �s�e�p�a�r�a�t�i�o�n� �m�e�c�h�a�n�i�s�m� �i�s� �b�a�s�e�d� �o�n� �g�e�l� �f�i�l�t�r�a�t�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �a�n�d� �e�l�u�t�i�o�n� �i�s� �a�c�h�i�e�v�e�d� �v�i�a� �s�i�m�p�l�e� �d�i�s�t�i�l�l�e�d� �w�a�t�e�r�.� �A� �l�a�r�g�e�r� �m�o�l�e�c�u�l�e� �e�l�u�t�e�s� �a�h�e�a�d�.
●Separation ability of each column
Fig. 2-21
MCI GEL™ column Counter ion Separation ability(degree of polymerization)
MCI GEL™ CK04S Na+ 8~9
MCI GEL™ CK04SS Ag+ 12~13
MCI GEL™ CK02A Na+ 15~16
MCI GEL™ CK02AS Ag+ 19~20
MCI GEL™ CK04SS�…MCI GEL™ CK04S �…
1510102
103
104
5
MW
MCI GEL™ CK02AS�…MCI GEL™ CK02A �…
30 40 50 60 7020102
103
104
10
MW
2
Elution volumeElution volume
●Peak retention time for Sugars and Sugar alcohols on various columns〔min〕
Column tempColumn sizeElueuntFlow rateSampleInjection vol.
: CK08EC…75℃, CK08E…45℃, CK08ES…75℃: 8mm I.D.×300mm
: H2O: 0.6: 1% aq. solution: 20µl * ; These sugars, containing Fructose component,
may partially be decomposed by CK08ES and CK08EH.
CK08ECCa2+
CK08ENa+
CK08ESAg+
Stachyose
Melezitose
Raffinose
Gentiobiose
Cellobiose
Trehalose
Isomaltose
Sucrose
Maltose
Melibiose
Lactose
Maltulose
Lactulose
Glucose
Xylose
Galactose
Mannose
Rhamonse
Fructose
Fucose
Inositol
Arabinose
Digitoxose
Adonitol
Erythritol
Mannitol
Salicin
Dulcitol
Xylitol
Sorbitol
Ribose
9
10
11
12
13
14
15
16
17
18
20
22
23
24
25
minStachyose
Melezitose
Raffinose
Gentiobiose
Cellobiose
Trehalose
Sucrose
Isomaltose
Melibiose
Maltose
Maltulose
Lactose
Lactulose
Glucose
Mannitol
Rhamonse
Adonitol
Sorbitol
Digitoxose
Mannose
Xylose
Galactose
Fructose
Inositol
Xylitol
Fucose
Dulcitol
Arabinose
Erythritol
Ribose
Salicin
8
9
10
11
12
13
17
15
27
14
min*Melezitose
*Stachyose
*Raffinose
*Sucrose
Trehalose
Cellobiose
Gentiobiose
Maltose
Isomaltose
Maltulose
Lactose
Melibiose
Lactulose
Adonitol
Digitoxose
Rhamnose
Glucose
Xylose
Xylitol
Erythritol
Mannitol
Fructose
Dulcitol
Galactose
Sorbitol
Mannose
Arabinose
Fucose
Ribose
Inositol
Salicin
12
13
14
15
16
17
18
19
20
20
21
21
23
52
min
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
13 14
Comparison data of authentic malto-oligosaccharides samples
Application data of CK04S
Fig. 2-29 Honey
:MCI GEL™ CK04S 10mm I.D.×200mm:H2O :0.4 (Fig. 2-29, 2-30)0.3 (Fig. 2-31):85℃(Fig. 2-29, 2-30)45℃(Fig. 2-31):RI
Fig. 2-30 Jam Fig. 2-31 Fructo-oligosaccharides
Fig. 2-26 MCI GEL™ CK04S10mm I.D.×200mm
Fig. 2-28 MCI GEL™ CK02AS20mm I.D.×250mm
Fig. 2-27 MCI GEL™ CK04SS10mm I.D.×200mm
min.0 10D
p 5 Dp
4D
p 3
Dp
2G
luco
se Glu
cose
Dp
2
Fruc
tose
20 30 min.0 10
Dp
4D
p 3
Fruc
tose
20 30 min.0 10 20
Dp
6 Sucr
ose
Glu
cose
Fruc
tose
Dp
5D
p 4
Dp
3
4030
ConditionsColumn
EluentFlow rateColumn temp.Detection
min.0 10 20 30
Dp
2
Dp
1
Dp
3
Dp
2
Dp
2
Dp
1
Dp
1Dp
3
Dp
3
Dp
7
Dp 6
Dp
5D
p 4
Dp
4
Dp
4
Dp
5
Dp
5
0 min.10 20 30 0 20 40 min.60
Dp
7
Dp
7
Dp 6
Dp
6
Comparison data of malto-oligosaccharides
Fig. 2-22 MCI GEL™ CK04S10mm I.D.×200mm
Fig. 2-23 MCI GEL™ CK04SS10mm I.D.×200mm
Fig. 2-24 MCI GEL™ CK02A20mm I.D.×250mm
Fig. 2-25 MCI GEL™ CK02AS20mm I.D.×250mm
:H2O :0.4 (Fig. 2-22, 2-23, 2-26, 2-27) 1.0 (Fig. 2-24, 2-25, 2-28):85℃:RI
ConditionsEluentFlow rate
Column temp.Detection
100 min.20 30 40 50 60 20100 min.30 40 50 60
1
2
Dp 12Dp 13Dp 14Dp 15Dp 16Dp 17Dp 18Dp 19Dp 20
70
1
Dp 16
2Dp 11Dp 12Dp 13Dp 14Dp 15
Mal
tose
Mal
tose
Glu
cose
Glu
cose
Dp
3
Dp
3
Dp
4
Dp
4
Dp
5Dp
5
Dp
6Dp
6
Dp
7
Dp
9D
p 10
Dp
11
Dp
8
Dp
9D
p 10 D
p 7
Dp
8
40 min.8 12 16 20 24 12
2
1
840 min.16 20 24 28 32
2
1
Mal
tose
Glu
cose
Mal
tose
Glu
cose
Dp
3
Dp
3
Dp
4
Dp
4
Dp
5
Dp
5
Dp
6
Dp
6
Dp 9Dp 8Dp 7
Dp 13Dp 12Dp 11Dp 10
Dp
9D
p 8 D
p 7
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
15 16
CK10U
CK10U 6×120
High cross linkage cation exchange columnapplications; amino acids, amines, etc
Separation of amino acids
2
High cross linkage cation exchange columnapplications; amino acids, amines, etc
Fig. 2-32 Protein hydrolyzates amino acids
�A�s� �f�o�r� �a�n�a�l�y�s�i�s� �o�f� �a�m�i�n�o� �a�c�i�d�s� �b�y� �a� �c�a�t�i�o�n� �e�x�c�h�a�n�g�e� �c�o�l�u�m�n� �s�u�c�h� �a�s� �M�C�I� �G�E�L�™� �C�K�1�0�U�,� �M�C�I� �G�E�L�™� �A�F�R�2�-�P�C� �i�s� �r�e�c�o�m�m�e�n�d�e�d� �a�s� �a� �p�r�e�-�c�o�l�u�m�n�.� �T�h�e� �A�F�R�2�-�P�C� �c�o�l�u�m�n� �i�s� �v�e�r�y� �e�f�f�e�c�t�i�v�e� �t�o� �s�t�a�b�i�l�i�z�e� �b�a�s�e� �l�i�n�e� �b�e�c�a�u�s�e� �a�m�m�o�n�i�u�m� �i�n� �e�l�u�e�n�t� �i�s� �t�r�a�p�p�e�d� �i�n� �t�h�i�s� �c�o�l�u�m�n�.� �T�h�e� �a�m�m�o�n�i�u�m� �i�o�n� �m�a�y� �d�i�s�t�u�r�b� �b�a�s�e� �l�i�n�e� �s�t�a�b�i�l�i�t�y�.� �T�h�e� �A�F�R�2�-�P�C� �s�h�o�u�l�d� �b�e� �i�n�s�t�a�l�l�e�d� �b�e�t�w�e�e�n� �a�n� �o�u�t�l�e�t� �o�f� �H�P�L�C� �p�u�m�p� �a�n�d� �a�n� �i�n�l�e�t� �o�f� �s�a�m�p�l�e� �i�n�j�e�c�t�o�r�.� � �A� �g�r�a�d�i�e�n�t� �e�l�u�t�i�o�n�,� �c�o�m�m�o�n�l�y� �u�s�e�d� �f�o�r� �a�m�i�n�o� �a�c�i�d� �a�n�a�l�y�s�i�s�,� �i�s� �i�n�f�l�u�e�n�c�e�d� �b�y� �H�P�L�C� �i�n�s�t�r�u�m�e�n�t�.� �S�o� �t�o� �o�b�t�a�i�n� �a� �s�a�t�i�s�f�a�c�t�o�r�y� �c�h�r�o�m�a�t�o�g�r�a�m�,� �g�r�a�d�i�e�n�t� �c�o�n�d�i�t�i�o�n�s� �s�h�o�u�l�d� �b�e� �o�p�t�i�m�i�z�e�d� �i�n� �a�c�c�o�r�d�a�n�c�e� �w�i�t�h� �t�h�e� �H�P�L�C� �e�q�u�i�p�m�e�n�t�.
min.
Pro
0 20 40 60
Arg
PheLe
uIle
Ala
Gly
Val
Met
Cys
Lys
NH
3
Glu
Ser
Thr
Asp
His
Tyr
80
ConditionsColumn
Eluent
Flow rateColumn temp.Detection
:MCI GEL™ CK10U 6mm I.D. × 120mm:A 0.2N Na-citrate buffer pH3.15 B 0.2N Na-citrate buffer pH3.20 C 0.2N Na-citrate buffer pH4.20 D 0.8N Na-citrate buffer pH9.70 4-step-gradient:0.5:55℃:ninhydrin post-column reaction, VIS detector
Separation of amino acids
Fig. 2-33 Valine, β-Alanine Fig. 2-34 γ-Aminobutyric acid
γ-Aminobutyric acid↓
4 8 12 16
min.
2
1
0 8 16
min.
:MCI GEL™ CK10U 6mm I.D.×120mm:0.3M Na-phosphate pH5.0:0.5:40℃:210nm :1. Valine 2. β-Alanine
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
Fig. 2-35 cyclic amino acids
Fig. 2-36 alkyl amino acid
Fig. 2-37 basic amino acid and aromatic amino acids
:MCI GEL™ CK10U 6mm I.D.×120mm:0.2N Na-Citrate buffer pH5.2:0.5:55℃:570nm
ConditionsColumn
EluentFlow rateColumn temp.Detection
:MCI GEL™ CK10U 6mm I.D.×120mm:0.3M NaSO4 (pH5.7):0.5:60 degree:210nm
ConditionsColumn
EluentFlowTemp.UV
0 2.5 5 7.5 10
prol
ine
pipe
colic
aci
d
hydr
oxy
prol
ine
5hpa
2 3 5 76 84 5 1510 20 25
Alan
ine
Valin
ete
rt-le
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eis
oleu
cine
leuc
ine
nor-l
euci
ne -
met
hyl-l
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ne
Tyr
Orn
itine
phe
Lys
5-hy
drox
y ly
sine
NH
COOH
5-HPA
HO
NH
COOH
proline
NH
COOH
pipecolic aicd
NH
COOH
HO
hydroxyproline
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
17 18
Anion exchange columnapplications; sugars, carboxylic acids, nucleotidesCA08F Anion exchange columnapplications; sugars, carboxylic acids, nucleotides
2
Application data of CA08F
Fig. 2-38 Sugars
Fig. 2-39 Carboxylic acids
200 min.40 60 80 100
20100 min.30
Lact
ic a
cid
Acet
ic a
cid
Form
ic a
cid
Tarta
ric a
cid
Mal
ic a
cid
Mal
onic
aci
d
Citr
ic a
cid
40 50 60
Deo
xyrib
ose
Cel
lobi
ose
Mal
tose
Lact
ose
Rha
mno
seR
ibos
e
Man
nose
Fruc
tose
Fuco
seG
alac
tose
Xylo
se
Glu
cose
Mel
ibio
se
:MCI GEL™ CA08F 4.6mm I.D.×250mm:A 0.15M Borate buffer pH7.5 B 0.5M Borate buffer pH9.5 C 0.6M Borate buffer pH9.5 D 0.7M Borate buffer pH8.5 4-step-gradient:0.5:65℃
:2.5% Boric acid, 5% Monoethanolamine pH7.9 :1.0 150℃:Fluorescence Ex 360nm, Em 440nm
ConditionsColumn
Eluent
Flow rateColumn temp.Post column reactionReagent
Flow rateTemp. Detection
:MCI GEL™ CA08F 4.6mm I.D.×250mm:0.6M Na2SO4 pH3.0:0.5:60℃:210nm
ConditionsColumn
EluentFlow rateColumn temp.Detection
�M�C�I� �G�E�L�™� �C�A�0�8�F� �p�a�c�k�e�d� �c�o�l�u�m�n� �h�a�s� �b�e�e�n� �d�e�s�i�g�n�e�d� �f�o�r� �t�h�e� �a�n�a�l�y�s�i�s� �o�f� �n�u�c�l�e�o�t�i�d�e�s�,� �s�u�g�a�r�s�,� �a�n�d� �o�r�g�a�n�i�c� �a�c�i�d�s� �b�y� �a�n�i�o�n� �e�x�c�h�a�n�g�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �m�o�d�e�.�T�h�i�s� �c�o�l�u�m�n� �w�i�l�l� �p�r�o�v�i�d�e� �e�x�c�e�l�l�e�n�t� �s�e�p�a�r�a�t�i�o�n� �a�n�d� �s�h�o�r�t� �a�n�a�l�y�s�i�s� �t�i�m�e�.
Application data of CA08F
0 10 20 30 40 50 60
Asco
rbic
aci
d
Ace
tic a
cid
Lact
ic a
cid
Form
ic a
cid
Tarta
ric a
cid
Pyru
vic
acid
Mal
ic a
cid
Succ
inic
aci
d
Fig. 2-40 Carboxylic acids Fig. 2-41 Organic acid
Fig. 2-42 Carboxylic acids
:MCI GEL™ CA08F 4.6mm I.D × 250mm:0.1M NaH2PO4 pH3.3:0.4:55℃:210nm
Glu
coni
c ac
id
Glu
coni
c ac
id
min.0 10 20
min.20 40
Acet
ic a
cid
Citr
ic a
cid
Acet
ic a
cid
Lact
ic a
cid
ConditionsColumn
EluentFlow rateColumn temp.Detection
:MCI GEL™ CA08F 4.6mm I.D × 250mm:0.6M Na2SO4 pH2.0:0.5:60℃:210nm
ConditionsColumn
EluentFlow rateColumn temp.Detection
:MCI GEL™ CA08F lot 5F1502:0.6M Na2SO4 8 (pH4):0.5:60℃:7.3 Mpa:210nm
ConditionsColumn
EluentFlow rateTempPressUV 2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
19 20
High porous type anion exchange columnCDR10 High porous type anion exchange column
2
Application data of CDR10Fig. 2-43 Nucleic acids and related substances
:MCI GEL™ CDR10 4.6mm I.D.×250mm:A H2O B 6M Acetate buffer pH4.4 A→B 30min linear gradient:0.5:60℃:254nm
Fig. 2-44 Mono-nucleotides:MCI GEL™ CDR10 4.6mm I.D.×250mm:1M Acetate buffer pH3.3:1.2:60℃:254nm
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100 min.20 30 40 50
0 min.10 20 30 40
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ConditionsColumn
Eluent
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ConditionsColumn
EluentFlow rateColumn temp.Detection
Application data of CDR10
Fig. 2-45 Sugars
:MCI GEL™ CDR10 4.6mm I.D.×250mm:A 0.15M Borate buffer pH7.5 B 0.6M Borate buffer pH9.5 A→B60min linear gradient:0.5:65℃
:2.5% Boric acid, 5% Monoethanolamine pH7.9:0.5:150℃:Fluorescence Ex 360nm, Em 440nm
Fig. 2-46 Human urine
:MCI GEL™ CDR10 4.6mm I.D.×250mm:A 0.006M Acetate buffer pH4.4 B 6M Acetate buffer pH4.4 A→B 60min. linear gradient:1.0:60℃:254nm
200 min.40 60 80
0 min.20 40 60D
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lobi
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ConditionsColumn
Eluent
Flow rateColumn temp.Post column reactionReagentFlow rateTemp. Detection
ConditionsColumn
Eluent
Flow rateColumn temp.Detection
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
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pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
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guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
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guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
21 22
SCA04 4.6×150 PEEK
Cation chromatography column MCI GEL™ SCK01
Cation chromatography Column MCI GEL™ CHK45/C05
Anion chromatography column MCI GEL™ SCA04
Ion chromatography columns and materials
○Cation chromatography column MCI GEL™ SCK01○Cation chromatography column MCI GEL™ CHK45/C05○Anion chromatography column MCI GEL™ SCA04
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3 Ion chromatography columns and materials
Application data of SCK01
Column list
Fig. 3-1 Monovalent cations
:MCI GEL™ SCK01 6mm I.D.×50mm:5mM HNO3
:1.0:40℃:Conductivity(Fig. 3-1, 3-2, 3-3, 3-4, 3-5)254nm(Fig. 3-6)
Fig. 3-2 Amines Fig. 3-3 Monovalent cations in rain
Fig. 3-4 Monovalent cations in tap water Fig. 3-5 Sports drink Fig. 3-6 Nucloside
min.4 8 min.8
Na
Na
K
Na
K
K
NH4
4 12 min.84 12
min.4 8 min.84 min.84
LiNa
NH4
RbCs
K
Amm
onia
Urid
ine
Gua
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neC
ytid
ine
Aden
osin
e
Met
hyla
min
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imet
hyla
min
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e
ConditionsColumn EluentFlow rateColumn temp.Detection
Cation analysis
Pre-columnfor anion analysis MCI GEL™ SCA-PC 8mm I.D×10mm
Pre-columnfor cation analysis MCI GEL™ SCK-PC
MCI GEL™ CHK45/C05
6mm I.D×50mm
MCI GEL™ SCK01 6mm I.D×50mm Stainless steelcolumn
Stainless steelcolumn
Stainless steelcolumn
Stainless steelcolumn
PEEK column
Stainless steelcolumn
Anion analysis MCI GEL™ SCA04 4.6mm I.D×150mm
4.6mm I.D×150mm
Cation analysis
Cation analysis
MCI GEL™ SCK01 4.6mm I.D×150mm
*USP L31 column
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MCI GEL™ colum
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Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
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pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
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Column selection
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MCI GEL™ colum
n listChiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
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aterialsIon exchange colum
ns and m
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n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
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ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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MCI GEL™ material list
Bioseparation columns
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MCI GEL™ colum
n listChiral separationcolum
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ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
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Chiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
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MCI GEL™ material list
Compounds index
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n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
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MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
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カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
23 24
Application data of SCK01
Application data of CHK45/C05
Fig. 3-7 Alkaline earth metals
Fig. 3-10 Mono, Divalent cations
Fig. 3-8 Transition metals Fig. 3-9 Divalent cations
min.84 84
Zn Mn CaCo
Cd Sr
min.16 min.4
Ca
Mg
12
Ba
Sr
CaMg
:MCI GEL™ CHK45/C05(SUS) 4.6mm I.D.×150mm:4mM H2SO4
:1.2:40℃:Conductivity:100μL Li(0.5ppm),Na(1ppm),NH4(1ppm),K(4ppm),Mg(4ppm),Ca(4ppm)
ConditionsColumn
EluentFlow rateTemp.DetectionSample inj
2
Li+
K+
Na-
NH4-
Ca2+
Mg2+
AMAL
7
4 6 8 10 12
(Data provided by Professor Yokoyama of Yokohama National University)
Application data of SCA04
Fig. 3-11 Standard anions eluent ; VA/MDEA
Fig. 3-12 Standard anions eluent ; Potassium hydrogenphthalate
min.4 363228242016128
1
3
4
52
6
7
(System peak)
min.4 208 12 16
1
2
3
4
5
6 :MCI GEL™ SCA04 4.6mm I.D.×150mm:3mM KHP:1.2:40℃:Conductivity:1. F- 2. C 3. NO2- 4. Br- 5. NO3- 6. SO42-
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ SCA04 4.6mm I.D.×150mm:3mM VA 2.8mM MDEA pH6.2:1.2:40℃:Conductivity:1. F- 2. H2PO4- 3. C 4. NO2- 5. Br- 6. NO3- 7. SO42-
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
Fig. 3-13 Rain
A; Beginning of rain fall B; After 4 hours C; After 38 hours
71ppm 59ppm
22ppm
16 min.4 8 12 16 min.4 8 12 16 min.4 8 12
8ppmNO3-
19ppmSO42-
5ppm15ppm
2ppm6ppm
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
25 26
Application data of SCA04
Fig. 3-14 River water
:MCI GEL™ SCA04 4.6mm I.D.×150mm:3mM VA 2.8mM MDEA pH6.2:1.2:40℃:Conductivity
Conditions(Fig. 3-14, 3-15)Column
EluentFlow rateColumn temp.Detection
55ppmHCO3-
min.4 208 12 16
16ppm
8ppmNO3-
23ppmSO42-
Fig. 3-15 Sulfur compounds
Fig. 3-16 Instant coffee
4 20 min.8 12 16
1
2
3
Chloride
4 40 min.8 12 16 20 24 28 32 36
Nitrate
:MCI GEL™ SCA04 4.6mm I.D.×150mm:3.8mM VA 2.1mM MDEA pH4.5:1.2:40℃:Conductivity
ConditionsColumn
EluentFlow rateColumn temp.Detection
:MCI GEL™ SCA04 4.6mm I.D.×150mm:4mM KHP pH4.1:1.2:40℃:Conductivity:1. SO42- 2. S2O32- 3. SCN-
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
L25
L38
L37, L38
Bioseparation columns and materials
Bioseparation columns
○Ion-exchange chromatography columns XtalSpeed™ series
○Size-exclusion chromatography columns MCI GEL™ CQP series
�M�C�I� �G�E�L�T�M �b�i�o�s�e�p�a�r�a�t�i�o�n� �c�o�l�u�m�n�s� �a�r�e� �b�a�s�e�d� �o�n� �a� �h�y�d�r�o�p�h�i�l�i�c�,� �w�i�d�e�-�p�o�r�e�,� �a�n�d� �r�i�g�i�d� �p�o�l�y�m�e�r� �d�e�s�i�g�n�e�d� �f�o�r� �a�n�a�l�y�t�i�c�a�l� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �o�f� �p�r�o�t�e�i�n�s�,� �p�e�p�t�i�d�e�s�,� �e�n�z�y�m�e�s�,� �a�n�d� �o�t�h�e�r� �b�i�o�m�o�l�e�c�u�l�e�s�.
�M�C�I� �G�E�L�T�M �C�Q�P� �s�e�r�i�e�s� �a�r�e� �u�s�e�d� �f�o�r� �s�i�z�e�-�e�x�c�l�u�s�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y�.
�X�t�a�l�S�p�e�e�d�T�M �s�e�r�i�e�s� �a�r�e� �i�o�n�-�e�x�c�h�a�n�g�e� �c�o�l�u�m�n�s� �u�s�e�d� �f�o�r� �p�r�o�t�e�i�n� �p�u�r�i�f�i�c�a�t�i�o�n�.� �H�i�g�h�-�q�u�a�l�i�t�y� �t�a�r�g�e�t� �p�r�o�t�e�i�n�s� �a�r�e� �o�b�t�a�i�n�e�d� �w�i�t�h� �t�h�i�s� �c�o�l�u�m�n� �a�t� �a� �h�i�g�h� �r�e�c�o�v�e�r�y� �r�a�t�e�.� �X�t�a�l�S�p�e�e�d�T�M �s�e�r�i�e�s� �a�r�e� �u�s�e�d� �f�o�r� �b�o�t�h� �a�n�a�l�y�t�i�c�a�l� �a�n�d� �p�r�e�p�a�r�a�t�i�v�e� �p�u�r�p�o�s�e� �i�n� �p�r�o�t�e�i�n� �c�r�y�s�t�a�l�l�o�g�r�a�p�h�y� �a�n�d� �N�M�R� �r�e�s�e�a�r�c�h�.� �X�t�a�l�S�p�e�e�d�T�M �s�e�r�i�e�s� �a�r�e� �a�l�s�o� �u�s�e�d� �f�o�r� �a�n�t�i�b�o�d�y� �v�a�r�i�a�n�t� �a�n�a�l�y�s�i�s� �a�n�d� �p�r�o�t�e�i�n� �i�s�o�f�o�r�m� �a�n�a�l�y�s�i�s�.
Column name Type
4 Bioseparation columns and materials
USP Separation mode
MCI GEL™ CQP06
MCI GEL™ CQP10
MCI GEL™ CQP30
XtalSpeed™ SP01
XtalSpeed™ DA
Cation exchange
Anion exchange
Size exclusion
Size exclusion
Size exclusion
Sulfopropyl(SP)
Diethyl amino ethyl(DEAE)
Exclusion limit MW
Exclusion limit MW
Exclusion limit MW
~103
~104
~106
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
27 28
DA01
Φ4.6mm×50mm
Φ4.6mm×100mm
Φ7.5mm×100mm
Φ11.5mm×100mm
Name CodeColumn size Housing Functional Group
0-151-01
0-151-04
0-151-02
0-151-03
PEEK Diethylaminoethyl(DEAE)
SP01
Φ4.6mm×50mm
Φ4.6mm×100mm
Φ7.5mm×100mm
Φ11.5mm×100mm
0-152-01
0-152-04
0-152-02
0-152-03
PEEK Sulfopropyl (SP)
Ion exchange chromatography columns
Ion exchange chromatography columns
Column list
XtalSpeedTM series Ion exchange chromatography columns
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4Application data of XtalSpeed™ series
Fig. 4-1 Analysis of Rituximab
Fig. 4-2 Analysis of Hemoglobin A1C
Fig. 4-3 Comparison of loadability
-1.00E+04 4 8 12 16 20min
0
0.00E+00
1.00E+04
2.00E+04
3.00E+04
4.00E+04
VIS
415n
m(u
V) 5.00E+04
6.00E+04
7.00E+04
8.00E+04
9.00E+04
-1.00E+04 4 8 12 16 20min
0
0.00E+00
1.00E+04
2.00E+04
3.00E+04
4.00E+04
VIS
415n
m(u
V)
5.00E+04
6.00E+04
7.00E+04
8.00E+04
9.00E+04Hb A0
Hb A1c
Hb A0
Hb A1c
min min1050 25 302015 1050 25 302015
:XtalSpeed™ SP01 100 x 4.6mmI.D Column A (250 x 4mmI.D)
ConditionsColumn
:A, 20mM Na phophate (pH7.0) B, A + 1.0M NaCl:0.529 for XtalSpeed and 1.0 for ProPac:(A), 2.5-20.0%B over 30min + 20.0-100%B over 5min (C), 2.5-5.0%B over 30min + 5.0-100%B over 5min
Eluent
Flow rateGradient
Conditions:
:
:0-40%B(0-400mM NaCl)/40CV:50 micro grams of human kinase
Eluent
Flow rate
GradientSample
XtalSpeed™ SP 01column A
XtalSpeed™ SP 01column A
:XtalSpeed™ SP01 50 x 4.6mmI.D
ConditionsColumn
:A, 20mM Bis-Tris-HCl (pH6.0) B, A + 1M NaCl:0.5:5 - 40%B over 30min:VIS 415nm:35℃
Eluent
Flow rateGradientDetectionTemperature
Able-bodied person Diabetic patient
XtalSpeedTM DA01 (4.6*50mm)
Impu
ritie
s
kina
se
Impu
ritie
s
kina
se
Column Q (4.6*100mm)
XtalSpeedTM DA01 :0.6Competitor’s Column Q:1
Buffer A:50mM HEPES-NaOH(pH7)Buffer B:50mM HEPES-NaOH(pH7),1M NaCl
32 34 36 38 4032 3428 30 36 38 40 42
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MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
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カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
29 30
Aqueous size exclusion columns
Size exclusion chromatography columns
Column list
CQP series Aqueous size exclusion columns
MCI GEL™ column
MCI GEL™ CQP06
MCI GEL™ CQP10
Column dimensions Particle size[μm]
Packing materials
Pore size[nm]
Theoreticalplates number[TP/column]
Exclusion limit[PEG]
7.5mm I.D. ×600mm
USP
L25
L38
L37, L38
7.5mm I.D. ×600mm
10
10
12
20
10000
6000
~1×103
~1×104
MCI GEL™ CQP30 7.5mm I.D. ×600mm 10 60 6000 ~1×106
●CQP series
MCI GEL™ column
MCI GEL™ CQP06G
MCI GEL™ CQP10G
Column dimensions
4.0mm I.D.×50mm
4.0mm I.D.×50mm
MCI GEL™ CQP30G 4.0mm I.D.×50mm
●Guard columns
�S�i�z�e� �e�x�c�l�u�s�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �i�s� �a� �l�i�q�u�i�d� �c�h�r�o�m�a�t�o�g�r�a�p�h�i�c� �t�e�c�h�n�i�q�u�e� �w�h�i�c�h� �s�e�p�a�r�a�t�e�s� �s�o�l�u�t�e� �m�o�l�e�c�u�l�e�s� �a�c�c�o�r�d�i�n�g� �t�o� �t�h�e�i�r� �s�i�z�e� �i�n� �s�o�l�u�t�i�o�n�.� �T�h�e� �c�o�l�u�m�n� �i�s� �p�a�c�k�e�d� �w�i�t�h� �p�o�r�o�u�s� �p�a�r�t�i�c�l�e�s� �a�n�d� �s�e�p�a�r�a�t�i�o�n� �t�a�k�e�s� �p�l�a�c�e� �a�s� �a� �r�e�s�u�l�t� �o�f� �t�h�e� �d�i�f�f�e�r�e�n�t�i�a�l� �s�o�l�u�t�e� �d�i�s�t�r�i�b�u�t�i�o�n� �o�u�t�s�i�d�e� �a�n�d� �w�i�t�h�i�n� �t�h�e� �p�o�r�e�s� �o�f� �t�h�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�.� �S�o�l�u�t�e� �m�o�l�e�c�u�l�e�s� �w�h�i�c�h� �a�r�e� �l�a�r�g�e�r� �t�h�a�n� �t�h�e� �p�o�r�e�s� �o�f� �t�h�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �w�i�l�l� �b�e� �e�x�c�l�u�d�e�d� �a�n�d� �t�h�e�r�e�f�o�r�e� �w�i�l�l� �e�l�u�t�e� �f�i�r�s�t� �a�n�d� �h�a�v�e� �a� �l�o�w�e�r� �r�e�t�e�n�t�i�o�n� �t�i�m�e� �t�h�a�n� �t�h�e� �s�m�a�l�l�e�r� �o�n�e�.� �T�h�e� �C�Q�P� �s�e�r�i�e�s� �c�o�l�u�m�n�s� �b�a�s�e�d� �o�n� �a� �h�y�d�r�o�p�h�i�l�i�c� �p�o�l�y�m�e�r� �a�r�e� �d�e�s�i�g�n�e�d� �f�o�r� �a�n�a�l�y�s�i�s� �o�f� �w�a�t�e�r� �s�o�l�u�b�l�e� �p�o�l�y�m�e�r�s� �s�u�c�h� �a�s� �o�l�i�g�o�s�a�c�c�h�a�r�i�d�e�s� �a�n�d� �P�E�G�,� �e�t�c�.
4Application data of CQP series
Fig. 4-4 Calibration curve
:MCI GEL™ MCI GEL™ MCI GEL™ 7.5mm I.D.×600mm:H2O:1.0:ambient:RI:PEG 100μl inj.
Fig. 4-5 Separation of PEG mixture
:MCI GEL™ CQP30 7.5mm I.D.×600mm:H2O:1.0:25℃:RI:1. PEG 2. 3.
145,00040,0006,000
Fig. 4-6 Separation of protein mixture Fig. 4-7 Separation of gluconic acid and glucose
:MCI GEL™ CQP06 7.5mm I.D.×600mm:H2O:0.8:ambient:RI:1. 5% Gluconic acid 2. 5% Glucose
:MCI GEL™ CQP30 7.5mm I.D.×600mm:14mM:1.0:ambient:280nm:1. Ferritin(MW440,000) 2. Ovalbumin(MW43,000) 3. Myoglobin(MW17,500) 4. Cytochrome c(MW12,400)
10 15
CQP 10
CQP 30
CQP 06
20 2010
1
2
3
0 min.
20 3010
1
1
2
2
3
4
0 min.0 10 20 30 40 min.
MW
102
103
104
105
106
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
Elution volume
CQP06CQP10CQP30
2
3
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9
10
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9
10
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2
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10
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10
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10
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MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
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Analytical and preparative chromatography columns and materials for pharm
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Bioseparation columns
and materials
Ion chromatography
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Column selection
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MCI GEL™ colum
n listChiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
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pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
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Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
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SPE sorbent series
SPE sorbent series
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Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
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ns and m
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n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
Chiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
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pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
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ns and m
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MCI GEL™ colum
n listChiral separationcolum
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SPE sorbent series
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ns and m
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atography colum
ns and materials
Ion exchange columns
and materials
Column selection
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MCI GEL™ colum
n list
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Chiral separationcolum
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Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
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n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
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カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
31 32
Analytical and preparative chromatography columns and materials for pharmaceutical applications5 Analytical and preparative chromatography columns and materials for pharmaceutical applications
MCI GEL™ CHP20/C04
Separation mechanism of CHP series
●Description of MCI GELTM columns and materials
C=ColumnP=Material
Matrix type Particle size
○Polymeric partition chromatography columns and materials MCI GEL™ CHP series
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�T�h�e� �M�C�I� �G�E�L�T�M� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �a�r�e� �b�a�s�e�d� �o�n� �t�h�e� �s�a�m�e� �c�h�e�m�i�s�t�r�i�e�s� �o�f�f�e�r�e�d� �i�n� �t�h�e� �D�i�a�i�o�n�T�M� �a�n�d� �S�e�p�a�b�e�a�d�s�T�M� �s�y�n�t�h�e�t�i�c� �a�d�s�o�r�b�e�n�t� �r�e�s�i�n�s�.� �T�h�e�s�e� �p�o�l�y�m�e�r� �c�h�e�m�i�s�t�r�i�e�s�,� �l�i�k�e� �D�i�a�i�o�n�T�M� �H�P� �s�e�r�i�e�s� �a�n�d� �S�e�p�a�b�e�a�d�s�™� �S�P� �s�e�r�i�e�s�,� �a�r�e� �w�i�d�e�l�y� �u�s�e�d� �a�n�d� �d�o�c�u�m�e�n�t�e�d� �i�n� �t�h�e� �b�i�o�p�h�a�r�m�a�c�e�u�t�i�c�a�l� �i�n�d�u�s�t�r�y� �f�o�r� �f�e�r�m�e�n�t�a�t�i�o�n� �e�x�t�r�a�c�t�i�o�n�,� �t�h�e� �f�o�o�d� �i�n�d�u�s�t�r�y� �a�n�d� �i�n� �i�n�d�u�s�t�r�i�a�l� �c�h�r�o�m�a�t�o�g�r�a�p�h�i�c� �s�e�p�a�r�a�t�i�o�n�s�.� �T�h�e� �M�C�I� �G�E�L�T�M� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �a�r�e� �a�v�a�i�l�a�b�l�e� �a�s� �p�a�c�k�e�d� �c�o�l�u�m�n�s� �f�o�r� �a�n�a�l�y�t�i�c�a�l� �a�p�p�l�i�c�a�t�i�o�n�s�,� �a�n�d� �a�s� �b�u�l�k� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �f�o�r� �a�n�a�l�y�t�i�c�a�l�,� �p�r�e�p�a�r�a�t�i�v�e� �a�n�d� �p�r�o�d�u�c�t�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �a�p�p�l�i�c�a�t�i�o�n�s�.
5 4.6×150CHK45/C05
*CHP20/C04, CHP20/C10: USP classification is L21
Br
None
Cation exchange group
None
C18
4
10
4.6×15020×150
4
10
4.6×15020×200
4.6×1504.6×25010×25020×15020×250
4.6×1504.6×25010×15020×15020×250
CHP20/C04
44.6×15020×200CHPOD/C04
CHP20/C10
CHP07/C04
CHP07/C10
4 4.6×150CHK40/C04
4
10
4.6×15020×150
4.6×1504.6×25010×25020×15020×250
CMG20/C04
CMG20/C10
Weak cationexchange group
Column list●CHP column series
5
�M�C�I� �G�E�L�T�M� �C�H�P� �s�e�r�i�e�s� �a�r�e� �s�u�i�t�a�b�l�e� �f�o�r� �R�P� �a�n�d� �N�P� �c�h�r�o�m�a�t�o�g�r�a�p�h�y�.� �T�h�e�r�e� �a�r�e� �f�o�u�r� �k�i�n�d�s� �o�f� �c�o�l�u�m�n�s� �o�f� �v�a�r�i�o�u�s� �h�y�d�r�o�p�h�o�b�i�c�i�t�i�e�s�;� �p�o�r�o�u�s� �p�o�l�y�s�t�y�r�e�n�e�,� �m�o�d�i�f�i�e�d� �p�o�r�o�u�s� �p�o�l�y�s�t�y�r�e�n�e�,� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e�,� �a�n�d� �m�o�d�i�f�i�e�d� �p�o�r�o�u�s� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e�.� �T�h�i�s� �r�a�n�g�e� �o�f� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �o�f�f�e�r�s� �t�r�e�m�e�n�d�o�u�s� �s�c�o�p�e� �f�o�r� �a� �p�r�o�p�e�r� �s�e�l�e�c�t�i�o�n� �o�f� �c�o�l�u�m�n�s� �b�a�s�e�d� �o�n� �t�h�e� �p�r�o�p�e�r�t�i�e�s� �o�f� �t�h�e� �t�a�r�g�e�t� �c�o�m�p�o�u�n�d�s�.
Full range
Column size[mm I.D.×mm]
Particle size[μm] pH range
�P�o�l�y�s�t�y�r�e�n�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�H�P�2�0�/�C�0�4�,� �C�H�P�2�0�/�C�1�0�M�o�d�i�f�i�e�d� �p�o�l�y�s�t�y�r�e�n�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�H�P�0�7�/�C�0�4�,� �C�H�P�0�7�/�C�1�0�,� �C�H�K�4�0�/�C�0�4�P�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�M�G�2�0�/�C�1�0�M�o�d�i�f�i�e�d� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�H�P�O�D�/�C�0�4�,� �C�H�K�4�5�/�C�0�5
MCI GEL™ CHP07/C04, C10 > CHP20/C04, C10 > CHPOD/C04 ≥ ODS columns ≥ CMG20/C04, C10�P�o�l�y�m�e�r� �c�o�l�u�m�n�s� �f�o�r� �H�P�L�C�,� �w�i�t�h� �t�h�e�i�r� �s�u�p�e�r�i�o�r� �c�h�e�m�i�c�a�l� �r�e�s�i�s�t�a�n�c�e�,� �c�a�n� �b�e� �u�s�e�d� �w�i�t�h� �v�a�r�i�o�u�s� �m�o�b�i�l�e� �p�h�a�s�e�s� �o�f� �b�r�o�a�d� �p�H� �r�a�n�g�e�,� �a�c�i�d�i�c� �t�h�r�o�u�g�h� �a�l�k�a�l�i�n�e�.� �T�h�e�y� �h�a�v�e� �t�h�e� �f�o�l�l�o�w�i�n�g� �a�d�v�a�n�t�a�g�e�s� �d�u�e� �t�o� �t�h�e�i�r� �h�i�g�h� �h�y�d�r�o�p�h�o�b�i�c�i�t�i�e�s�:�1)�I�n� �r�e�v�e�r�s�e� �p�h�a�s�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�i�c� �m�e�t�h�o�d�s� �t�o� �s�e�p�a�r�a�t�e� �a�c�i�d�i�c� �o�r� �a�l�k�a�l�i�n�e� �c�o�m�p�o�u�n�d�s�,� �e�l�u�e�n�t�s� �t�h�a�t� �c�a�n� �s�u�p�p�r�e�s�s� �t�h�e�
ionic properties of such compounds are generally used. Polymer columns can be applied in these cases where ODS �c�o�l�u�m�n�s� �w�o�u�l�d� �b�e� �u�n�s�u�i�t�a�b�l�e�.
�2)Some extremely hydrophilic compounds, e.g., oligosaccharides, can be separated using strongly hydrophobic �C�H�P�0�7�/�C�0�4� �o�r� �C�H�P�0�7�/�C�1�0� �c�o�l�u�m�n�s�.
�3)� �P�o�l�y�m�e�r� �c�o�l�u�m�n�s� �c�a�n� �b�e� �w�a�s�h�e�d� �w�i�t�h� �a�c�i�d�i�c� �a�n�d�/�o�r� �b�a�s�i�c� �s�o�l�u�t�i�o�n�s� �i�n� �c�a�s�e� �o�f� �c�o�n�t�a�m�i�n�a�t�i�o�n�.�P�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �c�o�l�u�m�n�s�,� �C�M�G�2�0�/�C�0�4� �a�n�d� �C�M�G�2�0�/�C�1�0�,� �c�a�n� �b�e� �a�p�p�l�i�e�d� �b�o�t�h� �f�o�r� �r�e�v�e�r�s�e� �p�h�a�s�e� �a�n�d� �n�o�r�m�a�l� �p�h�a�s�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y�.Modified polystyrene packing, CHK40/C04, is a mixed-mode type material; both hydrophobic and hydrophilic �i�n�t�e�r�a�c�t�i�o�n�s� �o�c�c�u�r� �b�e�t�w�e�e�n� �t�h�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �s�u�r�f�a�c�e� �a�n�d� �t�h�e� �a�n�a�l�y�t�e�s�.� �T�h�i�s� �m�a�t�e�r�i�a�l� �i�s� �u�s�e�f�u�l� �f�o�r� �c�o�m�p�o�u�n�d�s� �t�h�a�t� are difficult to separate using existing ODS or other polymer-based columns. This column is also used in the normal �p�h�a�s�e� �m�o�d�e� �a�n�d� �s�h�o�w�s� �a� �u�n�i�q�u�e� �s�e�p�a�r�a�t�i�o�n� �p�r�o�f�i�l�e�.� All polymeric columns exhibit superior stability and yield in comparison to ODS columns, which may have free silanol groups even when end-capping agents have been used.
�T�h�e� �h�y�d�r�o�p�h�o�b�i�c�i�t�i�e�s� �o�f� �t�h�e� �c�o�l�u�m�n�s� �a�r�e� �i�n� �t�h�e� �f�o�l�l�o�w�i�n�g� �o�r�d�e�r�s�:
Product nameMatrix Type Functinal group USP
2~12
L21
Analytical and preparative chromatography columns and materials for pharmaceutical applicationsCHP column series
Styrene Divinylbenzene
Methacrylates
Analytical and preparative chromatography columns and materials for pharmaceutical applications
2
3
4
5
6
8
9
10
1
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9
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10 10
1
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6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
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5
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7
8
9
1
2
3
5
6
7
8
9
1
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4
6
7
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1
2
3
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5
7
8
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9 9
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10 10 10 10 10 10 10 10
1
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9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
33 34
Durability of polymeric column
Fig. 5-1 Column durability at pH12 comparison between CHP20/C04 and an ODS column
�T�h�e� �p�o�l�y�m�e�r�i�c� �R�P� �c�o�l�u�m�n�s� �a�r�e� �c�h�e�m�i�c�a�l�l�y� �s�t�a�b�l�e�.� �S�p�e�c�i�f�i�c�a�l�l�y�,� �t�h�e� �c�o�l�u�m�n�s� �h�a�v�e� �r�e�s�i�s�t�a�n�c�e� �t�o� �a�n� �a�l�k�a�l�i�n�e� �e�l�u�e�n�t�.� �T�h�e� �f�o�l�l�o�w�i�n�g� �g�r�a�p�h�s� �d�e�m�o�n�s�t�r�a�t�e� �s�t�a�b�i�l�i�t�y� �o�f� �t�h�e� �p�o�l�y�m�e�r�i�c� �c�o�l�u�m�n�s�.� �A�f�t�e�r� �f�e�e�d�i�n�g� �a� �s�o�l�u�t�i�o�n� �o�f� �p�H� �1�2� �i�n�t�o� �t�h�e� �M�C�I� �G�E�L�™� �C�H�P�2�0�/�C�0�4�,� �t�h�e�r�e� �i�s� �n�o� �c�h�a�n�g�e� �o�f� �c�o�l�u�m�n� �p�e�r�f�o�r�m�a�n�c�e�.
100 150 200500
1,2
0.4
0.6
0.2
0.8
1
0
degr
adat
ion
ratio
fiowing time hr.
CHP20/C04
ODS column
100 150 200500
1,2
0.4
0.6
0.2
0.8
1
0
degr
adat
ion
ratio
fiowing time hr.
CHP20/C04
ODS column
:MCI GEL™ CHP20/C04 4.6mmI.D × 150mm:20mM Na2HPO4 pH12/CH3CN/=60/40:0.4:25℃:254nm:1000ppm Dimethyl phthalate 5µL
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
COOH
NH2 H2N-CH2(CH2)2-CH3
Polystyrenic adsorbent Silica gel C4, C18 Polymethacrylic adsorbent
Polymethacrylic adsorbent Silica gel C4, C18
π-π interaction(double bond effect) Alkyl effect
Hydrogen bond effect Hydrogen bond effect
Hydrogen bond effect
HN
NH2
COOHNH
H2N
(CH2)n-CH3O
SiSi
H2N-CH2 HN NH
HN
OHO O
O OCOH
OSi
Si
H2NCOOH
NH2NH
HN
C
O O
O OC
C
Retentiveness in reverse phase mode
Hydrophobic interaction Interaction mechanism
Weak interactionStronge interaction
Hydrophobic interaction
Interaction mechanism
1
2
3
4
5
0 5 10 15 20 25 30 35 40 min.
1
2
3
0 5 10 15 20 25 30 35 40 min.
MeOOC COOMe
Phthalic acid dimethyl ester
EtOOC COOEt
Phthalic acid diethyl ester
PrOOC COOPr
Phthalic acid dipropyl ester
Application data of CHP series
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:50mM Na-phosphate pH2.0, 1.5% Hexanesulfonic acid / CH3CN=80/20:0.25:ambient:280nm:1. Epinephrine 2. Dopamine 3. 5-Hydroxy tryptophan 4. Serotonin 5. Tryptophan
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:H2O/CH3CN=50/50:0.75:60℃:254nm:1. Dimethyl phthalate 2. Diethyl phthalate 3. Dipropyl phthalate
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:H2O/CH3CN=10/90:0.4:25℃:275nm :1.Theophylline 2.Theobromine 3.Caffeine
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:0.1M NaH2PO4 pH2.0 CH3CN=88/12:0.3:25℃:275nm :1.Cinchonine 2.Quinine
Fig. 5-2 Separation of catecholamines Fig. 5-3 Separation of phthalic acid esters
HO
HOOH H
N
Epinephrine
HO
HO NH2
Dopamine
HO
NH
NH2
COOH
5-hydroxy tryptophan
HO
NH
NH2
Serotonin
12
3
0 5 10 15 20 25 min.
1
2
0 5 10 15 20 25 min.
Fig. 5-4 Purine alkaloids Fig. 5-5 Cinchona alkaloids
HN
N N
N
O
O
Theophylline
N
N N
HN
O
O
Theobromine
N
N N
N
O
O
Caffeine
N
HOHH
H
H
N
Cinchonine
N
HOHH
H
H
N
O
Quinine
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
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2
4
5
6
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9
10
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2
3
5
6
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9
10
1
2
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10
1
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5
8 8
9
10
1
2
3
4
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6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
35 36
Application data of CHP series
Comparison with an ODS column
Fig. 5-6 Uric acid and related compounds
Fig. 5-7 Bile acidsCHP20/C04
ODS column
1
2
3
1
3
2
13
2
4 5
0 5 10 15 20 min.
0 5 10 15 20 min.
0 5 10 15 20 min.
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:10mM TBA/CH3CN=75/25:0.4:25℃:284nm :1.Hypoxanthine 2.Xanthine 3.Theophylline 4.Uric acid 5.Orotic acid
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:50mM NaH2PO4 pH2.0 /CH3CN=40/60:0.3:25℃:210nm:1.Cholic acid 2.Ursodeoxycholic acid 3.Deoxycholic acid
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:ODS column (5μm) 4.6mm I.D.×150mm:50mM NaH2PO4 pH6.0 /CH3CN=40/60:0.3:25℃:210nm:1.Cholic acid 2.Ursodeoxycholic acid 3.Deoxycholic acid
N
N NH
HN
O
Hypoxanthine
HN
N N
N
O
O
Theophylline
HN
NH
N
HN
O
O
Xanthine
NH
HN
COOH
O
Orotic acid
O
HN
NH
N
HN
O
O
HO
Uric acid
H
OHH
COOH
HO
Ursodesoxycholic acid
H
OHH
COOH
HO
cholic acid
OH
H
H
COOH
HO
deoxycholic acid
OH
Application data of CHP series
Fig. 5-9 Adrenal cortex hormones
Fig. 5-8 Glycyrrhizae radix
min.
min.
Glycyrrhizic acid
0 30 35 4020 2515105
2
3
1
0 3020 2515105
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:2.06% acetic acid/CH3CN =63/37:0.5:45℃:254nm:Extract of glycyrrhizae radix
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:H2O/CH3CN:60/40:0.5:45℃:280nm:1.Hydrocortisone 2.Corticosterone 3.11-Deoxycortisol
Glycyrrhizic acid
HO
HO
H
H
O
H
OH
OOH
HOH
H
HO H
O
H
OHO
HOH
HOH H
HO HHO
O
OHO
HOOH
O
H
H H
O
HOOH
O
H
H H
OHO
OH
O
H
H H
hydrocortisone corticosterone 11-deoxycortisol
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
37 38
Comparison with an ODS column
Fig. 5-10 Ingredients of medicine
Fig. 5-11 Sulfa drugs
1
2
3
4
0 3020 2515105 min.
1
2
34
0 3020 2515105 min.
Application data of CHP series
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CMG20/C04 4.6mm I.D.×150mm
:20mM phosphate pH6.8/CH3CN =82/18:0.5:45℃:254nm:1.Succinylsulfathiazole 2.Sulfanilamide 3.Sulfathiazole 4.Sulfamerazine
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CMG20/C04 4.6mm I.D.×150mm:50mM phosphoric acid(pH2.0)/CH3OH =60/40:0.5:45℃:254nm:1.4-Dimethylaminoantipyrine 2.Antipyrine 3.Caffeine 4.Aspirin 5.Phenacetin
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:ODS column 4.6mm I.D.×150mm
:20mM phosphate pH6.8/CH3CN =90/10:0.5:45℃:254nm:1.Succinylsulfathiazole 2.Sulfanilamide 3.Sulfathiazole 4.Sulfamerazine
min.
1
2
3
4
5
0 3020 2515105
NN
O
Antipyrine
NN
O
DimethylaminoantipyrineAminopyrine
N
COOH
OAc
Aspirin
NHAc
O
Phenacetin
N
N N
N
O
O
Caffeine
S
HN
OO
N
N
NH2
Sulfamerazine
S
HN
OO
N
S
HN
OOH
O
Succinylsulphathiazole
S
HN
OO
N
S
NH2
sulphathiazole
SH2N
OO
NH2
Sulfanilamide
Application data of CHP series
0 108642 min.min.
2
1
3
4
Fig. 5-15 Water-soluble vitaminsFig. 5-14 Procainamide, Procaine
1
2
0 252015105
O
ON
H2N
Procaine
NH
ON
H2N
Procainamide
NH2
O
N
Vitamin B3
C-NCo3+
N
N-
N
N
N
NO
H2N
O
H2N
O
NH2O
OH
H2N
O
OHN
NH2
O
NH2
O
OP
HO
O-OO
Vitamin B12
NH
NHOOH
N
HO
OS
ONH
O
NH2HO
ONH
O
NH2HO
OH
O
NHN
N
O
NH
ONH
HN
O
HO
O
NH
O
NHOH
ONH
O
NH2
NH
HO
O
NH
H2N
H
0 108642 min.
2
1
3 4
0 40302010 min.
2
1
3
HN
HN O
OHN
HO O
ONH
O
NH2HO
N
OHHO
HO
Vitamin B6
OHOHO
OHHO
OH
Vitamin C
Gly-Tyr
Met Enkephalin
Leu Enkephalin
Angiotensin ll
Fig. 5-12 Peptides Fig. 5-13 Proteins
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CMG20/C04 4.6mm I.D.×150mm
:8mM Na2HPO4 pH7.0/CH3CN =85/15:0.5:25℃:254nm:1.Vitamin C 2.Vitamin B6 3.Vitamin B3 4.Vitamin B12
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CMG20/C04 4.6mm I.D.×150mm
:20mM phosphate pH7.2/CH3CN =65/35:0.5:45℃:254nm:1.Procainamide 2.Procaine
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CMG20/C04 4.6mm I.D.×150mm
:0.1%TFA/CH3CN =70/30:0.5:25℃:220nm :1.Gly-Tyr 2.Met Enkephalin 3.Leu Enkephalin 4.Angiotensin ll
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
:MCI GEL™ CMG20/C04 4.6mm I.D.×150mm:A;0.05%TFA/CH3CN =80/20 B;0.05%TFA/CH3CN =20/80 A→B 30min.linear:0.5:25℃:280nm:1.Ribonuclease A 2.Cytochrome c 3.α-Chymotrypsinogen A
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
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9
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10 10 10 10 10 10 10 10
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3
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5
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9
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11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
39 40
Application data of CHP series
Pravastatin sodiumSimvastatin
MevastatinMevastatin
Impurity Impurity
SimvastatinPravastatin sodium
Nystatin
Amphotericin BAmphotericin B
Nystatin
Filipin
Filipin
OHO OH
O
HO
ONa
OH
Pravastatin sodium
O
O O
OHO
H
(+)-Simvastatin, Simvastatin
O
O
OHO
O
H
(+)-Compactin; Mevastatin
Fig. 5-16 Pravastatin sodium
CHP20/C10 10μm ODS 10μm
min.0 5 10 15 20 25 min.0 5 10 15 20 25
min.0 5 10 15 min.0 5 10 15
CHP20/C10 10μm ODS 10μm
Fig. 5-17 Polyene antibiotics
UV
238
nm (A
U)
UV
238
nm (A
U)
:MCI GEL™ CHP20/C10 (10μm 250 ×4.6mm I.D.) and ODS (10μm 250 ×4.6mm I.D.) : A :0.1% Formic acid; B :0.1% Formic acid in AcCN; A/B=60/40;:1.00:25℃:UV305nm for Nystatin, VIS405nm for Amphotericin B and UV340nm for Filipin; :Pravastatin sodium, Mevastatin and Simvastatin, 1mg/ml each;. :10μl
ConditionsColumn
Eluent
Flow rateColumn temp.Detection
Sample
Injection
:MCI GEL™ CHP20/C10 (10μm 250 ×4.6mm I.D.) and ODS (10μm 250 ×4.6mm I.D.) : A :0.1% Formic acid; B :0.1% Formic acid in AcCN; : 45%B-95%B over 29min.:1.00:25℃:UV238nm :Pravastatin sodium, Mevastatin and Simvastatin, 1mg/ml each;.:5μl
ConditionsColumn
Eluent
GradientFlow rateColumn temp.DetectionSampleInjection
OHOH
O
O
OH
OH
OH OH OH OH
OH
H
Filipin
O
O
O
OH OH OH OH
OH
OHOH
OH
O OH
O
O
OHH2N
HO
Nystatin
O
O
OHH2N
HO
HO
HO
OHO O OH OHOH OH OH
OH
O O
Amphotericin B
min.0
4
3
2
1
10 20 30
5
Application data of CHP series
CHP20/C10 10μm ODS 10μm
Fig. 5-19 Proteins
Ribonuclease A Conalbumin Ribonuclease A Conalbumin
ConditionsColumn Eluent
Flow rateColumn temp.DetectionSampleInjection
:150 ×4.6mm I.D. : A :0.1% TFA; B :0.1% TFA in AcCN:1.00:20%B-60%B over 20min;:UV280nm; :Ribonuclease A and Conalbumin 2mg/ml;. :10μl
Fig. 5-18 Proteins
:MCI GEL™ CMG20/C10 4.6mm I.D.×250mm:A 0.05% TFA/CH3CN=80/20 B 0.05% TFA/CH3CN=30/70 A → B 45min linear gradient:0.5:25℃:280nm:1. Ribonuclease A 2. Cytochrome C 3. Transferrin 4. α-Chymotrypshinogen A 5. β-Lactoglobulin
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSample
min. min.0 105 15 20 25 0 105 15 20 25
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7 7 7 7 7 7 7 7 7
9
1
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9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
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9
1
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5
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7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
41 42
ConditionsColumn
Eluent
GradientFlow rateColumn temp.DetectionSampleInjection
:
: : :::::
MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mmA) 0.1%TFA, H2OB) 0.1%TFA, AcCN10%B→60%B over 25min.1.040℃230nmGhrelin rat and Ghrelin human ,0.1mmol/l each10μl
Fig. 5-21 Ghrelin
Application data of CHP series
CMG20/C10 10μm ODS 10μm
CHP20/C10 10μm
ODS 10μmCMG20/C10 10μm
Insulin glargine
UV2
30nm
(AU
)U
V230
nm(A
U)
UV2
30nm
(AU
)
UV2
30nm
(AU
)
UV2
30nm
(AU
)
Insulin human recombinant
Insulin glargine Insulin human recombinantInsulin glargine Insulin human recombinant
Ghrelin rat Ghrelin humanGhrelin rat
Ghrelin human
0 5 10 15 20min.
0 5 10 15 20min.
0 2 4 6 8 10 1412 1816 20min.
0 2 4 6 8 10 1412 1816 20min.
0 5 10 15 20min.
ConditionsColumn
Eluent
GradientFlow rateColumn temp.DetectionSampleInjection
:MCI GEL™ CHP20/C10 MCI GEL™ CMG20/C10 ODS 10μm 4.6mm I.D.×150mm:A) 0.1%TFA, H2O B) 0.1%TFA, CH3OH:20%B→60%B over 20min.:1.0:40℃:280nm:Insulin Glargine and human recombinant , 1mg/ml each:10μl
Fig. 5-20 Insulin
Application data of CHP series
CMG20/C10 10μm ODS 10μm
TargetU
V210
nm(A
U)
Impurity
Target
Impurity
0 5 10 15 20 25 30 35 40min.
UV2
10nm
(AU
)
0 5 10 15 20 25 30 35 40min.
ConditionsColumn
EluentFlow rateColumn temp.DetectionSampleInjection
:
::: :::
MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mm0.1%TFA,/CH3CN=68/321.0ml/min40℃210nmSifuvirtide crude(purity 35.5%) 2.1mg/ml0.4ml
Fig. 5-23 Sifuvirtide
Fig. 5-22 Leuprorelin
ConditionsColumn
Eluent
GradientFlow rateColumn temp.DetectionSampleInjection
MCI GEL™ CHP20/C10MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mmA) 0.1%TFA, H2OB) 0.1%TFA, AcCN20%B→60%B over 20min.1.040℃280nmLeuprorelin,LHRH human, LHRH salmon and Buserelin ,1mg/ml each10μl
:
: ::: :::
0 2 4 6 8 10 12 14 min. 0 2 4 6 8 10 12 14 min.
Leuprorelin LeuprorelinBuserelin
Buserelin
Leuprorelin Buserelin
LH-RH salmon LH-RH salmon
LH-RH human
LH-RH human
LH-RH salmon
LH-RH human
CMG20/C10 10μm
CHP20/C10 10μm
UV2
30nm
(AU
)
ODS 10μm
UV2
30nm
(AU
)
0 2 4 6 8 10 12 14 min.
UV2
30nm
(AU
)
2
3
4
5
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7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
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9
1
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8
1
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3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
43 44
Application data of CHP series
Fig. 5-25 Nucleotide
Fig. 5-24 ssRNA Ladder Marker
ConditionsColumn
Eluent
Gradient
Flow rateColumn temp.DetectionSampleInjection
:MCI GEL™ CMG20/C10 ODS 10μm 4.6mm I.D.×150mm:A)100mM TEAA, H2O B)100mM TEAA, CH3CN:CHP10/C10 ODS 10μm:1.0:40℃:260nm:14-30 ssRNA Ladder Marker [max.0.04mg/ml]:5μl
10%B→40%B over 30min8%B→40%B over 30min
0-4.0min 0%B 4.0-5.0min 0→30%B 5.0min-6.0min 30%B 6.0min-7.0min 30→50%B7.0min-10.0min 50→65%B 10.0min-11.0min 65%B 11.0min- 0%B
1.Ura,2.Xan,3.Thy,4.Hyp,5.Gua,6.Cyt,7.Ade, 8.Urd,9.Xao,10.dT,11.Ino,12.Guo,13.Cyd,14.Ado
B)20 mM Na2HPO4 / 100 mM NaClO4 / 30% ACN
ConditionsColumn
Eluent
Gradient
Flow rateColumn temp.DetectionSampleInjection
:MCI GEL™ CHK40/C04 4.6mm I.D.×150mm:A)19 mM H3PO4 / 1 mM NaH2PO4 / 5.0% ACN : :0.8:50℃:UV260nm::20μl
tR / mim
inte
nsity
/ -
Ura
Urd
Xan
Xao
Ino Th
y
dT
Hyp
Guo
Gua
Ade
Cyd
Cyt
Ado
0 2 4 6 8 10 12 14
0 5 10 15min.
ODS 10μm 40℃
CHP20/C10 40℃
CHP20/C10 60℃
UV
260n
m(A
U)
18 base
14 base22 base
26 base30 base
(Data provided by Professor Yokoyama of Yokohama National University)
Application data of CHP series
LinaloolUV2
10nm
(AU
)
0 2 864 10分
CMG20/C10 10μm
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
Injection
:
:::::
:
Fig. 5-26 Linalool
0 5 10 15 20min.
CMG20/C10 10μm
UV2
10nm
(AU
) 12
3
4 5
0 5 10 15 20min.
ODS 10μm
UV2
10nm
(AU
)
1
2
3
4
5
ConditionsColumn
EluentFlow rateColumn temp.DetectionSampleInjection
:MCI GEL™ CMG20/C10 4.6mm I.D.×150mm:Hexan/Ethanol=99.5/0.5:1.0:40℃:210nm:Coriander:10μl
MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mmHexan/Ethanol=99.5/0.51.040℃210nm1:Linalyl Acrtate 1mg/ml2:Linalool 1mg/ml3:β-Citronellool 1mg/ml4:Nerol 0.5mg/ml5:Geraniol 0.5mg/ml10μl
Fig. 5-27 Coriander
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7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
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9
1
2
3
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9
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9
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2
3
4
5
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8
9
1
2
3
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9
1
2
3
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5
6
7
9 9
1
2
3
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5
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7
8
1
2
3
4
5
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8
9
1
2
3
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5
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7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
45 46
Application data of CHP series
(TritonX-100)
min. min.
Fig. 5-32 ODS-1HU (ODS)Fig. 5-31 C18-alkylated aliphatics CHPOD/C04
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CHPOD/C04 4.6mm I.D.×150mm:50vol%CH3CN:0.50:40℃:254nm:Triton X-100 (Polyoxyethylene octyl phenyl ether) 1% each 10μL
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ ODS-1HU 4.6mm I.D.×250mm:50vol%CH3CN:1.00:40℃:254nm:Triton X-100 (Polyoxyethylene octyl phenyl ether) 1% each 10μL
n=9.6 n=9.6
Fig. 5-33 Application data of Nucleic base/Nucleoside and Beer
0-0.7min 0%B 0.7-3.0min 0→40%B 3.0-3.2min 40%B3.2-3.5min 40→80%B 3.5-8.0min 80%Β 8.0min- 0%B
ConditionsColumn
Eluent
Gradient
Flow rateColumn tempDetectionInjection
:MCI GEL™ CHK45/C05 4.6mm I.D.×150mm:A)8 mM H3PO4
B)10 mM H3PO4 /30% ACN
:1.3:45℃:UV(260nm):20μl
1211109876543210
1211109876543210
1211
Draft Beer
Carbohydrate-free "happoshu-type" beer
A new category of beer that contains 85% less purine
109876543210
Analysis of various category beer
Urd
Ura
dT
Cyd
Urd
Urd
Ura
dT Cyd
Ino
Xan
Guo
Gua
dA Ade
Ino
Ura Ino
Xan
dT Xan
Guo
Guo
Gua
Gua
dA
Ade
0
Inte
nsity
/-
Ino
Ura
Xan
Hyp
Xao
Urd
AMP
UM
P
Cvd
Guo
dT
GD
P
Cvt
dCG
ua
dA
Ade
Ado
tR / min2 4 6 8 10 12
(Data provided by Professor Yokoyama of Yokohama National University)
Application data of CHP series
(Polyphenon 60)Fig. 5-30 Styrene Divinylbenzene CHP20/C04Fig. 5-29 Modified Styrene Divinylbenzene
CHP07/C04ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CHP20/C04 4.6mm I.D.×150mm:CH3OH/10mM-Acetic acid=60/40:0.46:60℃:280nm:Polyphenon 60(10mg/ ) each 10μL
ConditionsColumn
EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CHP07/C04 4.6mm I.D.×150mm:CH3OH/10mM-Acetic acid=60/40:0.46:60℃:280nm:Polyphenon 60(10mg/ ) each 10μL
(Data provided by Professor Yokoyama of Yokohama National University)
Fig. 5-28 Application data of CHK40/C04:Sepatation of Sartans
N
O
HO
O
NH
N
NN
Valsartan
N
ON
HO O
NHNNN
Candesartan
O
N
N
HN NN N
Irbesartan
NN
HO
Cl NHNNN
Losartan
ConditionsColumn
Eluent
Gradient
Flow rateColumn temp.DetectionSample
Injection
:MCI GEL™ CHK40/C04 4.6mm I.D.×150mm: :
:1.0:50℃:UV:Candesartan(CAN),Losartan(LOS), Valsartan(VAL), Irbesartan(IRB) :20μl
A)10 mM Na H↓ 2 PO↓ 4 +0.2 mM Na↓ 2 HPO↓ 4 (25%ACN)B)10 mM Na H↓ 2 PO↓ 4 +1.0 mM Na↓ 2 HPO↓ 4 (40%ACN)0.5min 0%B 0.5-2.0min 50%B2.0min- 90%Β
min.min.
min.642
CAN
LOS
VAL
IRB
0
2
3
4
5
6
8
9
10
1
3
4
5
6
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9
10
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10
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1
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1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
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9
1
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5
6
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8
9
10 10
1
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6
7
8
9
1
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3
5
6
7
8
9
1
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4
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9
1
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4
5
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8
9
1
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3
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9
1
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4
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7
9 9
1
2
3
4
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8
1
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3
4
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6
7
8
9
1
2
3
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6
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8
1
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3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
47 48
●CHP material series
Polymethacrylate
Styrene Divinylbenzene
CHP20/P20
CHP20/P30
CHP20/P50
CHP20/P70
CHP20/P120
20
30
50
70
120
CHP07/P120
CHP50/P20
CHP50/P30
CSP50/P10
20
30
10
120
drug compoundsPeptidesProteins
CMG20/P10
CMG20/P30
CMG20/P150
10
30
150
CHP20/C04
CHP20/C10
CHP20/C10
CMG20/C04
CMG20/C10
CHP07/C04
CHP07/C10
-
Product nameBase polymer
None
None
Br
Functionalgroup
Mainapplication
EquivalentHPLC column
Particlesize[μm]
25
45
25
25
25
Porediameter
[nm]
Analytical and preparative chromatography columns and materials for pharmaceutical applications
5
CHP material series Analytical and preparative chromatography columns and materials for pharmaceutical applications
�M�C�I� �G�E�L�™� �C�H�P� �m�a�t�e�r�i�a�l� �s�e�r�i�e�s� �a�r�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �m�a�t�e�r�i�a�l�s� �o�f� �p�o�r�o�u�s� �t�y�p�e� �p�o�l�y�m�e�r�s�.
�B�e�c�a�u�s�e� �p�o�l�y�m�e�r�i�c� �m�a�t�e�r�i�a�l�s� �a�r�e� �c�h�e�m�i�c�a�l�l�y� �s�t�a�b�l�e�,� �w�i�d�e� �p�H� �r�a�n�g�e�,� �f�r�o�m� �a�c�i�d�i�c� �t�o� �a�l�k�a�l�i�n�e� �e�l�u�e�n�t�s� �a�r�e� �a�b�l�e� �t�o� �b�e� �a�p�p�l�i�e�d� �t�o� �M�C�I� �G�E�L�™� �C�H�P� �m�a�t�e�r�i�a�l� �s�e�r�i�e�s�.
�M�C�I� �G�E�L�™� �C�H�P�5�0� �s�e�r�i�e�s� �a�n�d� �C�H�P�2�0� �s�e�r�i�e�s� �a�r�e� �b�o�t�h� �S�T�/�D�V�B� �p�o�l�y�m�e�r�s�,� �b�u�t� �t�h�e�y� �d�i�f�f�e�r�e�n�c�e�s� �i�n� �p�o�r�o�s�i�t�y�.� � �P�o�r�e� �s�i�z�e� �o�f� �C�H�P�2�0� �s�e�r�i�e�s� �i�s� �f�a�i�r�l�y� �l�a�r�g�e�r� �t�h�a�n� �t�h�a�t� �o�f� �C�H�P�5�0� �s�e�r�i�e�s�.� � �A�p�p�r�o�p�r�i�a�t�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �c�a�n� �b�e� �s�e�l�e�c�t�e�d� �i�n� �a�c�c�o�r�d�a�n�c�e� �w�i�t�h� �m�o�l�e�c�u�l�a�r� �s�i�z�e� �o�f� �i�n�j�e�c�t�i�o�n� �s�a�m�p�l�e�s�.
Application data of CHP 50
Fig. 5-36 Extract of green tea leaves
0 5 10 15 20 25 30 min.
min.
1
2
3
MeOOC COOMe
Phthalic acid dimethyl ester
PrOOC COOPr
Phthalic acid dipropyl ester
EtOOC COOEt
Phthalic acid diethyl ester
0
20
40
60
80
100
-0.1
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
0 1 2 3 4 5 6 7
MeO
H (%
)
UV
280
nm (A
U)
BV
ConditionsColumnEluent
Flow rateDetectionSample
:MCI GEL™ CHP50/P20, 32mmI.D×465mm:0−185min, CH3OH:0.01M Acetic acid(35:65) 185−350min, CH3OH:0.01M Acetic acid(50:50):7.48:280nm:extract of green tea leaves, injection volumn 18.7 1. Epigallocatechin 2. Catechin 3. Epicatechin 4. Epigallocatechin gallate 5. Gallocatechin 6. Epicatechin gallate 7. Caffeine
CHP50/P20(20μm)
CHP50/P30(30μm)
CHP20/P50(50μm)
CHP20/P70(70μm)
CHP20/P120(120μm)
Penicllin V
Penicllin G
6-Aminopenicillanic acid
O
ON
SCONH
COONa
CH3
CH3
HH
ON
SCONH
COONa
CH3
CH3
HH
ON
S
COONa
CH3
CH3
H2NHH
1
2
3
1
1
1
1
22
2
2
3 3
3
3
Fig. 5-34 Phthalic acid esters Fig. 5-35 Penicilin antibiotics
ConditionsColumnEluentFlow rateColumn temp.DetectionSample
Injection
:MCI GEL™ CHP50/P20, 10mml I.D.×250mmL:H2O/CH3CN=20/80:0.75:25℃:254nm,:1.Dimethyl phthalate 0.5% 2.Dipropyl phthalate 0.5% 3.Dibutyl phthalate 0.5%:100μl
ConditionsColumnEluentFlow rateColumn temp.DetectionSample
Injection
:MCI GEL™ CHP series, 10mml I.D.×250mmL:CH3OH/0.05M Phosphate buffer (pH8.0)=60/40:2.18:25℃:254nm,:1.6-Aminopenicillanic acid 1000ppm 2.Penicillin G 1000ppm 3.Penicillin V 1000ppm:100μl
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
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6
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9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
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1
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9 9
1
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5
6
7
8
9
10 10 10 10 10 10 10 10
1
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3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
49 50
Application data of CHP 20
ConditionsColumn
Eluent
Flow rateDetectionSample
:MCI GEL™ CHP20/P30 32mm I.D.×490mm:CH3OH + 1% Acetic acid = 60 + 40 (vol.):7.88:270 nm:Extract of senna pulv., partially purified by Diaion HP20 injected amount : 39.4
Fig. 5-38 Elution profile of senna pulv. extract separated on MCI GEL™ CHP20/P30
Fig.5-37 Senna pulv. extract
0 105 2015 3025 4035 5045 60 min 55 0 105 2015 3025 4035 5045 60 min 55 0 105 2015 3025 4035 5045 60 min 55
Sennoside APurity: 90.3%,
Recovery: 60.9%
Conditions
Column
EluentFlow rateDetectionSample
Chromatogram A:MCI GEL™ CHP20/C10 4.6mm I.D.×250mm:CH3OH/1% Acetic acid = 60/40 (vol.) :0.5:270nm:Extract of senna pulv. 10μL
Chromatogram B:MCI GEL™ CHP20/P20 10.0mm I.D.×250mm:CH3OH/1% Acetic acid = 60/40 (vol.) :2.4:270nm:Extract of senna pulv. 80μL
Chromatogram C:MCI GEL™ CHP20/P30 10.0mm I.D.×250mm:CH3OH/1% Acetic acid = 60/40 (vol.) :2.4:270 nm:Extract of senna pulv. 80μL
Sennoside ASennoside B
Sennoside B
Sennoside A
Sennoside B
Sennoside A
Sennoside B
Sennoside A
(C)CHP20/P30 (30μm) (B)CHP20/P20 (20μm) (A)CHP20/C10 (10μm)
0 60 120 180 240 300 min
Application data of CHP series
0 60 120 180 min
Fig. 5-39 Elution profile of gardenia fructus extract separated on MCI GEL™ CHP20/P30
Fig. 5-40 Capsicin
ConditionsColumn EluentFlow rateColumn temp.DetectionSampleInjection
:MCI GEL™ CMG20/C10, 4.6mmI.D.×250mm MCI GEL™ CMG20/P150, 20mmI.D.×500mm:Hexane/EtOH=87.5/12.5;:1.00 for CMG20/C10, 2.36ml/min for CMG20/P150;:25℃:UV 280nm:Capsici Fructus extract;:20ml for CMG20/C10, 1.5ml for CMG20/P150.
ConditionsColumn
Eluent
Flow rateDetectionSample
:MCI GEL™ CHP20/P30 32mm I.D.×490mm:CH3OH + H2O = 65 + 35 (vol.):7.88:420 nm:Extract of gardenia fructus injected amount : 39.4
CMG20/C10 (10μm) CMG20/P150 (150μm)
0
UV
280
nm (A
U)
5 10 15min
20 25 30 0
UV
280
nm (A
U)
80 160 240min
320 400 480
CapsicinDihydrocapsaicin CapsicinDihydrocapsaicin
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
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10
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2
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5
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8
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10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
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5
6
7
8
9
10 10
1
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9
1
2
3
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7
8
9
1
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9
1
2
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8
9
1
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9
1
2
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9 9
1
2
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8
1
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6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
51 52
Application data of CHP series
Fig. 5-44 Elution profile of tocopherol and tocotrienol in preparative scale
min.0 20 40 60 80 100 120 140 160 180 200
1
44
77 31 3
Fig. 5-41 Vitamin E in Rice Bran Oil
ConditionsColumn
EluentFlow rateDetectionSampleInjection
:MCI GEL™ CMG20/C10 4.6mm I.D.×150mm:Hexane-EtOH = 98/2 (vol.):0.5:295nm:Rice Bran Oil, 50:10μL
Fig. 5-42 Elution profile of Rice Bran Oil in preparative scaleConditionsColumn
EluentFlow rateDetectionSampleInjection
:MCI GEL™ CMG20/P30 20mm I.D.×500mm:Hexane/C2H5OH = 98/2 (vol.):4.7:295 nm:Rice Bran Oil, 50:1260μL
0.9 1.1
1
3
5 7
6 8
4
2
1.3 1.5BV
1.7 1.9 2.1
Fig. 5-43 Mixture of tocopherol and tocotrienol : Comparison with silica gel column
min.
Silica gel
CMG20/C10
10 20 30 40
8
8
7
7
1
1
3
4
4
5
5
(2) (6)
2 6
ConditionsColumn
Eluent
Flow rateColumn temp.DetectionSampleInjection
:1. Silica gel 5SIL, 4.6mmI.D.×250mm 2. MCI GEL™ CMG20/C04, 4.6mmI.D.×150mm:1. Hexane/EtOH = 99/1 2. Hexane/EtOH = 98/2 :1.0:25℃:UV 292nm:Mixture of tocopherol and tocotrienol:10μl( 1mg/mL )
ConditionsColumnEluentFlow rateColumn temp.DetectionSampleInjection
:MCI GEL™ CMG20/P150, 41.2mmI.D.×550mm, ×4:Hexane/EtOH = 90/10:49.0 (SV=1.0):25℃:UV 292n:Mixture of tocopherol and tocotrienol:150 mL ( 50g/L )
TocotrienolTocopherol
5. α-tocotrienol6. β-tocotrienol7. γ-tocotrienol8. δ-tocotrienol
R1CH3CH3HH
R2CH3H
CH3H
R3CH3CH3CH3CH3
1. α-tocopherol 2. β-tocopherol 3. γ-tocopherol 4. δ-tocopherol
R1CH3CH3HH
R2CH3H
CH3H
R3CH3CH3CH3CH3
min.0 6 12 18 24 30 36
CH3
CH3CH3CH3CH3
R1
R2
R3
O
HO
CH3
CH3CH3CH3CH3
R1
R2
R3
O
HO
Tocotrienolgroup
Tocopherolgroup
CRS10W 4.6×50 CRS15W 4.6×50
Chiral separation columns
○Chiral separation columns MCI GEL™ CRS10W (DLAA)MCI GEL™ CRS15W (LDAA)
●Separation mechanism
Separation mechanismFig. 6-1 DL-IsoleucineApplication of CRS10W
�M�C�I� �G�E�L�™� �C�R�S�1�0�W� �a�n�d� �i�t�s� �c�o�m�p�a�n�i�o�n� �p�r�o�d�u�c�t� �M�C�I� �G�E�L�™� �C�R�S�1�5�W� �(�a�n� �o�p�t�i�c�a�l� �i�s�o�m�e�r� �o�f� �C�R�S�1�0�W�)� �a�r�e� �b�a�s�e�d� �o�n� �a� �3μ�m� �w�i�t�h� �1�0�n�m� �m�e�a�n� �p�o�r�e� �d�i�a�m�e�t�e�r� �o�f� �s�i�l�i�c�a� �g�e�l� �c�o�a�t�e�d� �w�i�t�h� �N�,�N�-�D�i�o�c�t�y�l� �-�L�(�o�r� �D�)�-�a�l�a�n�i�n�e� �w�h�i�c�h� �i�s� �a� �n�o�v�e�l� �o�p�t�i�c�a�l� �a�c�t�i�v�a�t�e�d� �l�i�g�a�n�d�.� �T�h�e� �c�h�i�r�a�l� �r�e�s�o�l�u�t�i�o�n� �m�e�c�h�a�n�i�s�m� �i�s� �a� �c�o�m�b�i�n�a�t�i�o�n� �o�f� �l�i�g�a�n�d� �e�x�c�h�a�n�g�e� �a�n�d� �h�y�d�r�o�p�h�o�b�i�c� �i�n�t�e�r�a�c�t�i�o�n�.� �A� �c�o�p�p�e�r� �s�u�l�f�a�t�e� �a�q�u�e�o�u�s� �s�o�l�u�t�i�o�n� �i�s� �u�s�e�d� �a�s� �a�n� �e�l�u�e�n�t�.� �E�l�u�t�i�o�n� �s�a�m�p�l�e�s� �a�r�e� �d�i�r�e�c�t�l�y� �d�e�t�e�c�t�e�d� �a�t� �w�a�v�e� �l�e�n�g�t�h� �o�f� �2�5�4� �n�m� �b�e�c�a�u�s�e� �c�o�m�p�l�e�x� �c�o�m�p�o�u�n�d�,� �c�o�m�p�o�s�e�d� �o�f� �s�a�m�p�l�e� �m�o�l�e�c�u�l�e� �a�n�d� �c�o�p�p�e�r� �i�n� �t�h�e� �e�l�u�e�n�t�,� �a�r�e� �o�b�j�e�c�t� �o�f� �d�e�t�e�c�t�i�o�n�.� �W�i�t�h� �t�h�e� �C�R�S�1�0�W�,� �D�-�i�s�o�m�e�r�s� �g�e�n�e�r�a�l�l�y� �e�l�u�t�e� �i�n� �f�r�o�n�t� �o�f� �L�-�i�s�o�m�e�r�s� �w�h�i�l�e� �L�-�i�s�o�m�e�r�s� �e�l�u�t�e� �a�h�e�a�d� �o�f� �D�-�i�s�o�m�e�r�s� �o�n� �t�h�e� �C�R�S�1�5�W�.� �T�h�e� �h�y�d�r�o�p�h�o�b�i�c� �i�n�t�e�r�a�c�t�i�o�n� �m�e�c�h�a�n�i�s�m� �a�l�l�o�w�s� �h�y�d�r�o�p�h�i�l�i�c� �s�a�m�p�l�e�s� �t�o� �e�l�u�t�e� �f�a�s�t�e�r� �t�h�a�n� �h�y�d�r�o�p�h�o�b�i�c� �m�o�l�e�c�u�l�e�s�.� �L�o�n�g� �a�l�k�y�l� �c�h�a�i�n� �o�r� �a�r�o�m�a�t�i�c� �c�o�m�p�o�u�n�d�s� �w�i�l�l� �e�l�u�t�e� �l�a�t�e� �o�r� �r�e�q�u�i�r�e� �a�n� �o�r�g�a�n�i�c� �s�o�l�v�e�n�t� �(�C�H�3�C�N� �o�r� �C�H�3�O�H�,� �m�a�x�.� �o�f� �1�5�v�/�v�%�)� �t�o� �p�r�e�v�e�n�t� �a�d�s�o�r�p�t�i�o�n� �o�n�t�o� �t�h�e� �s�t�a�t�i�o�n�a�r�y� �p�h�a�s�e�.
●Separation performance
●USP L32 column
O
O
HONH
O N RR
allo-L
L
allo-D
D
20 400 min.
�1�.
�2�.�
�3�.�
�T�h�e� �C�R�S� �s�e�r�i�e�s� �c�o�l�u�m�n�s� �s�e�p�a�r�a�t�e� �o�v�e�r� �2�0� �D�,�L�-α�-�A�m�i�n�o� �a�c�i�d�s� �b�y� �o�n�l�y� �s�i�n�g�l�e� �c�o�l�u�m�n�.� �T�h�e� �c�o�l�u�m�n�s� �s�e�p�a�r�a�t�e� �n�o�t� �o�n�l�y� α�-�A�m�i�n�o� �a�c�i�d�s� �b�u�t� �a�l�s�o� α�-�H�y�d�r�o�x�y� �c�a�r�b�o�x�y�l�i�c� �a�c�i�d�s� �a�n�d� �d�e�r�i�v�a�t�i�v�e� �a�m�i�n�o� �a�c�i�d�s� �s�u�c�h� �a�s� �A�c�e�t�y�l�a�t�e�d� �a�m�i�n�o� �a�c�i�d�s�.�T�h�e� �c�o�l�u�m�n�s� �p�r�o�v�i�d�e� �e�x�c�e�l�l�e�n�t� �r�e�s�o�l�u�t�i�o�n� �o�p�e�r�a�t�e�d� �a�t� �r�o�o�m� �t�e�m�p�e�r�a�t�u�r�e�.�T�h�e� �c�o�l�u�m�n�s� �s�h�o�w� �h�i�g�h� �d�u�r�a�b�i�l�i�t�y�.
Cu2+
sample moleculeopticalactivated ligand
ligandexchange
hydrophobicinteraction
non-polar surface
base material
6 Chiral separation columns
Separation mechanism and performance of MCI GEL™ CRS series
2mM CuSO4/H2O0.5
MCI GEL™ column USPParticle size (μm)Column dimensions
MCI GEL™ CRS10W
MCI GEL™ CRS15W
4.6×50mm
4.6×50mm
L32
L32
3
3
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
53 54
Fig. 6-2 Separation of amino acids mixture
For all chromatograms, column temperature is room temperature and wave length is 254nm. All eluents are CuSO4 aqueous solution except for Fig. 6-9 and Fig. 6-10.
D isomers elute ahead of L isomers.
Fig. 6-3 Separation of amino acids mixture
Fig. 6-4 Separation of DL-Ser.
D isomers elute ahead of L isomers.0.1mM CuSO4,0.5
Fig. 6-5 Separation of DL-aspartic acid
2mM CuSO4,0.5
Fig. 6-6 Separation of DL-glutamic acid
Fig. 6-8 Separation of DL-lysine
Fig. 6-7 Separation of DL-histidine
2mM CuSO4,1.0
0.1mM CuSO4,0.5
0.1mM CuSO4,0.2
Fig. 6-9 Separation of DL-phenylalanine2mM CuSO4/CH3OH=85/15(vol)1
Fig. 6-10 Separation of DL-tryptophan
Fig. 6-12 Durability testFig. 6-11 Separation of DL-lactic acid
2mM CuSO4/CH3OH=85/15(vol)1
2mM CuSO4,0.5
0.5mM CuSO4,1.0Column temp. :ambientDetection:254nm
Tyr
Leu
Nleu
Met
ProVal
NVal
D L
Eth Phe
40 60200 min. 40200 min.
200 min.
200 min.
200 min.200 min.20
LD LDLD
LD
0 min.
200
D L D L
D
L
D-Pro
D-Val
L-ProL-Val
min. 600 min. 200 min. 200 min. 200 min.
The sample was continuously injected 800 times for approximately 500 hrs. Changes of retention times and separation ability are not observed.
Application data of CRS10W
Fig. 6-13 Separation of DL-α-Phenylglycine
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:2mM CuSO4/CH3OH=85/15:1.0:25℃:254nm:1. D-α-Phenylglycine 2. L-α-Phenylglycine
Fig. 6-14 Separation of methionine and acetylmethionine
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:2mM CuSO4/CH3CN=90/10:1.0:25℃:254nm:1. D-Met 2. L-Met 3. Acetyl-D-Met 4. Acetyl-L-Met
Fig. 6-16 Separation of diaminopimelic acid
10
3
2
1
20 min.604030 50
5
4
3
2
1
10 min.10
2
1
20 min.
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:2mM CuSO4
:0.5:25℃:254nm:
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:0.4mMCuSO4
:1.0:ambient:UV 254nm:D/L Aspartic acid
ConditionsColumn EluentFlow rateTemp.DetectionSample
Application data of CRS10W
Fig. 6-15 D/L-Aspartic acid
1050 2520 353015
1. D,D-2,6-Diaminopimelic acid2. meso-2,6-Diaminopimelic acid3. L,L-2,6-Diaminopimelic acid
D
L
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
55 56
Fig. 6-17 Separation of 2-hydroxy carboxylic acids
Fig. 6-18 Separation of 2-hydroxy carboxylic acids
03
2
1
min.5010 20 30 40
4
5
6
0
3
2
1
min.4010 20 30
4
5
6 7
8
Application data of CRS10W
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:2mM CuSO4/CH3CN=90/10:1.0:ambient:254nm:1,2=D,L-Lactic acid 3,4=D,L-2-Hydroxy-n-butyric acid 5,6=D,L-α-Hydroxy-n-valeric acid 7,8=D-,L-α-Hydroxy isocaproic acid
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:2mM CuSO4/CH3CN=90/10:1.0:ambient:254nm:1,2=D,L-p-Hydroxymandelic acid 3,4=D,L-m-Hydroxymandelic acid 5,6=D,L-Mandelic acid
ConditionsColumn EluentFlow rateColumn temp.DetectionSample
Fig. 6-19 D/L Alanine Fig. 6-20 DL-P-Hydroxyphenylglycine
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:0.1mMCuSO4
:1.0:30℃:UV 254nm:D/L Alanine
ConditionsColumn EluentFlow rateTemp.DetectionSample
:MCI GEL™ CRS10W 4.6mm I.D.×50mm:2mMCuSO4:MeOH=85:15:1.0:30℃:UV 254nm:DL-P-ydroxyphenylglycine
ConditionsColumn EluentFlow rateTemp.DetectionSample
D
L
D L
7.55.02.50.0 7.55.02.50.0
Fig. 6-21 Separation of DL-alanine
Fig. 6-22 Analysis of a trace of L-lactic acid in 50 ppm D-lactic acid
CRS15W CRS10W
CRS15W CRS10W
The CRS15W is recommended for analysis of a trace of L-isomer in a principal D-isomer when the CRS10W does not provide an adequate chromatogram.
0.1mM CuSO4
0.5
2mM CuSO4
0.5
0 10 0 10
L
D
←L
D
L
D
STAR
T
STO
P
10
STAR
T
STO
P
10
min. min.
min. min.
L
D
Comparison data of CRS10W and CRS15W
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
57 58
Notes
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
Orn•HCI
Lys•HCI
Ala
His•HCI
Ser
Thr
Cit
Hyp
Pro
Val
Nval
Asp
Glu
Ileu(DL)
Ileu(allo)
Leu
Nleu
Met
Tyr
Eth
Phe
0.1
0.1
0.1
0.1
0.1
0.1
0.5
1.0
1.0
1.0
1.0
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2.0
2.0
0.2
0.2
0.5
0.5
0.5
0.5
0.5
0.2
1.0
1.0
1.0
0.5
1.0
0.5
0.5
1.0
1.0
1.0
1.0
1.0
1.0
6.8
7.7
11.0
10.5
10.1
11.3
10.4
23.8
7.3
8.9
11.5
13.2
16.2
30.4
21.9
14.6
24.1
10.3
22.5
26.4
37.8
<1
<1
1.4
1.7
1.0
1.3
2.3
1.1
4.5
5.0
4.7
0.8
2.3
6.5
6.0
4.6
6.5
2.6
5.3
5.0
6.3
1.26
1.45
1.39
1.63
1.25
1.29
1.75
1.23
2.13
2.04
2.07
1.18
1.54
2.14
1.97
1.97
2.16
1.64
1.85
1.69
1.84
Amino acidsCuSO4 aq. soln.
[mM]Flow rate[ ]
Retention time; L-isomers
[min]
Separationfactor
[α]
Separationrate[Rs]
�1�.�2�.�3�.
�4�.
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Examples of chromatographic conditions and datas
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7
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・
・
・
・
Material list
Solid phase extraction sorbentsSPE sorbent series Solid phase extraction sorbents
CHP85/P120
CHP87/P120
CHPOD/P30
Small molecules extraction
CSP800Enrichment of trace of organic compounds
SFP08/P25 Small molecules extraction
middle
small
large
middle
middle
full range
full range
2~12
full range
full range
120
120
30
120
25
Typical Application
CHL10P
CHL20P
CLB10P
Iminodiaceteic acid
Polyamine
Glucamine
>1.5
>1.8
>1.0
2-6
2-6
>3
120
120
120
Name
Typical ApplicationName
Metal Extraction
Metal Extraction
ExtractionBron Removal
Effective pH range
pH rangePore size
880-940
820-910
340-380
790-920
>1000
Mean particle size[μm]
Mean particle size[μm]
Surface area[m2/g]
Functional group[ ]
Ion exchange capacitymeq/
●Synthetic adsorbents and reversed-phase materials
●Chelating type
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
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10 10
1
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1
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1
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1
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1
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1
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8
1
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6
7
8
9
1
2
3
4
5
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7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
59 60
8
0-019-01 CK10U 6×120
0-003-02 CK04SS 10×200
0-001-01
0-001-02
0-003-01
CK02A
CK02AS
CK04S
20×250
20×250
10×200
0-111-01
0-119-01
CA08F
CDR10
4.6×250
4.6×250
Ion exchange chromatography cation exchange resin for sugars
Ion exchange chromatography cation exchange resin for carboxylic acids
Ion exchange chromatography anion exchange resin for carboxylic acids and sugars
Ion chromatography for cations
Ion chromatography for anions
Bioseparation for size exclusion
Ion exchange chromatography cation exchange resin for amino acids
Ion exchange chromatography cation exchange resin for oligosaccharides
0-034-01
0-034-04
0-407-01
SCK01
SCK01
CHK45/C05
6×50
4.6×150
4.6×150
0-133-02 SCA04/PEEK 4.6×150
0-213-01
0-214-01
0-215-01
CQP06
CQP10
CQP30
7.5×600
7.5×600
7.5×600
Main column
Code No. Name Column dimensions[mm]
Guard/Pre-column
MCI GEL™ column list
6×50
6×508×10
8×10
8×10
4×10
4×10
6×508×10
6×50
4.6×30
8×10
4×50
4×50
4×50
Column dimensions[mm]
AFR2-PC
CK10SGCK04SSG
CK02AG
CK02ASG
CA08FG
CDR10G
CK10SGCK04SG
SCK-PC
SCA04G
SCA-PC
CQP06G
CQP10G
CQP30G
Name
0-033-21
0-017-110-003-12
0-001-11
0-001-12
0-111-11
0-119-11
0-017-110-003-11
0-034-21
0-133-12
0-130-22
0-213-11
0-214-11
0-215-11
Code No.
6×50CK08EHG0-010-15L170-010-05
0-010-08
CK08EH 8×300
7.8×300
0-009-01
0-010-01
0-010-02
0-010-03
CK08S
CK08E
CK08EC
CK08ES
8×500
8×300
8×300
8×300
6×50
6×50
6×50
6×50
CK08SG
CK08EG
CK08ECG
CK08ESG
0-009-11
0-010-11
0-010-12
0-010-13
L58
L58
L19
0-010-06
0-010-07
7.8×300
7.8×300
L58
L58
L31
L25
L38
L37, 38
USP
Code No. Name Column dimensions[mm]
Analytical and preparative chromatography columns for pharmaceutical applications [CHP column series]
Main column Guard/Pre-column
Column dimensions[mm]
NameCode No.
0-401-05
0-401-03
CHP20/C04
CHP20/C04
4.6X150
20X150
0-504-01
0-504-04
CHPOD/C04
CHPOD/C04
4.6X150
20X200
0-404-01
0-407-01
CHK40/C04
CHK45/C05
4.6X150
4.6X150
0-402-05
0-402-03
0-406-06
0-202-05
0-202-02
0-202-03
0-202-04
CMG20/C04
CMG20/C04
CMG20/C10
CMG20/C10
CMG20/C10
CMG20/C10
CMG20/C10
4.6X150
20X150
4.6X150
4.6X250
10X250
20X150
20X250
0-405-01
0-405-04
0-405-06
0-406-01
0-406-02
0-406-03
0-406-04
CHP07/C04
CHP07/C04
CHP07/C10
CHP07/C10
CHP07/C10
CHP07/C10
CHP07/C10
4.6X150
20X200
4.6X150
4.6X250
10X150
20X150
20X250
L21
L21
L21
L21
L21
L21
L21
L39
L39
L39
L39
L39
L39
L39
0-403-05
0-403-01
0-403-02
0-403-03
0-403-04
CHP20/C10
CHP20/C10
CHP20/C10
CHP20/C10
CHP20/C10
4.6X150
4.6X250
10X250
20X150
20X250
USP
2
3
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5
6
8
9
10
1
3
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6
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9
10
1
2
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10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
61 62
9
Characteristics
MCI GEL™ material list
1.Excellent performance�S�p�h�e�r�e� �p�a�c�k�i�n�g� �a�n�d� �s�h�a�r�p� �p�a�r�t�i�c�l�e� �s�i�z�e� �d�i�s�t�r�i�b�u�t�i�o�n� �p�r�o�v�i�d�e� �h�i�g�h� �p�e�r�f�o�r�m�a�n�c�e�.
2.Persistence and highest quality�P�r�o�d�u�c�e�d� �w�i�t�h� �M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l�’�s� �e�x�c�e�l�l�e�n�t� �t�e�c�h�n�o�l�o�g�y�,� �e�x�p�e�r�i�e�n�c�e� �a�n�d� �u�n�d�e�r� �s�t�r�i�c�t� �q�u�a�l�i�t�y� �c�o�n�t�r�o�l�.
3.Wide range of product line�M�C�I� �G�E�L�™� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �i�n�c�l�u�d�e� �i�o�n� �e�x�c�h�a�n�g�e� �r�e�s�i�n�s� �(�c�a�t�i�o�n� �a�n�d� �a�n�i�o�n�)�,� �n�o�n�-�f�u�n�c�t�i�o�n�a�l�i�z�e�d� �p�o�l�y�m�e�r� �u�s�e�d� �f�o�r� �r�e�v�e�r�s�e�d� �p�h�a�s�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �a�n�d� �o�t�h�e�r� �v�a�r�i�e�t�i�e�s� �o�f� �p�r�o�d�u�c�t�s�.� �A�l�s�o� �M�C�I� �G�E�L�™� �o�f�f�e�r�s� �m�e�a�n� �p�a�r�t�i�c�l�e� �s�i�z�e� �o�f� �4� μ�m� �t�o� �a�p�p�r�o�x�i�m�a�t�e�l�y� �3�0�0� μ�m� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s�,� �t�h�i�s� �m�e�a�n�s� �t�h�a�t� �M�C�I� �G�E�L�™� �p�r�o�d�u�c�t�s� �a�r�e� �a�p�p�l�i�e�d� �t�o� �a�n�a�l�y�s�i�s� �u�s�e� �a�n�d� �p�r�e�p�a�r�a�t�i�v�e� �u�s�e�.
4.Abundant experience�M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l� �h�a�s� �b�e�e�n� �s�u�p�p�l�y�i�n�g� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �f�o�r� �m�o�r�e� �t�h�a�n� �5�0� �y�e�a�r�s�.
MCI GEL™ material list ●Ion exchange chromatography cation exchange resins [CK series, AFR series]
1-001-01
1-003-011-003-021-003-03
1-004-011-004-021-004-03
1-009-011-009-021-009-03
1-010-011-010-021-010-03
1-013-011-013-02
1-014-01
1-017-011-017-021-017-03
1-018-011-018-02
1-019-011-019-031-019-04
1-020-051-020-06
1-024-02
1-021-01
1-033-01
CK02A
CK04SCK04SCK04S
CK06SCK06SCK06S
CK08SCK08SCK08S
CK08ECK08ECK08E
CK08YCK08Y
CK08P
CK10SCK10SCK10S
CK10FCK10F
CK10UCK10UCK10U
CK10MCK10M
CK12U
CK10Y
AFR2
Na+
Na+
Na+
Na+
Na+
Na+
H+
Na+
Na+
Na+
Na+
Na+
Na+
H+
20
11
11
11
9
25
120
11
7
5
4
5
25
25
Oligosaccharides
Oligosaccharides
Oligosaccharides
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Carboxylic acids,Amino acids
Amino acids
Amino acids
Amino acids
Amino acids
Amino acids
Ammonia trap
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
RSO3-
2
4
6
8
8
8
8
10
10
10
10
12
10
−
>4.5
>4.5
>4.45
>4.40
>4.40
>4.40
>1.8
>4.3
>4.3
>4.3
>4.3
>4.3
>4.3
>2.7
Abbreviation; ST/DVB = Styrene-divinylbenzene copolymer
Code No. NamePacking
size[g]
Counter ion Typical ApplicationBase material Functionalgroup
Crosslinkage
[%]
10
102550
102550
102550
102550
50300
100
102550
510
3 510
5 3
5
50
5
Meanparticle size
[μm]
Ion exchangecapacity[ ]g
(meq/ )
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
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7
8
9
1
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5
6
7
8
9
1
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4
6
7
8
9
1
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4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
63 64
●Ion chromatography materials [SCA, SCK series]
Code No. NamePacking
size[g]
Counter ion Typical ApplicationBase material Functionalgroup
Abbreviations; ST/DVB = Styrene-divinylbenzene copolymer HMA = Polyhydroxymethacrylate QA = Quaternary ammonium
Meanparticle size
[μm]
Abbreviations; HMA = Polyhydroxymethacrylate SP = Sulfopropyl CM = Carboxymethyl DEAE = Diethylaminoethyl QA = Quaternary ammonium
●Bioseparation columns -Ion exchange materials- [CQA series, CQK series]
1-127-01
1-131-01
CQA31P
CQA35P
100
100
Cl-
Cl-
30
30
HMA
HMA
DEAE
QA
<11
2~12
60
60
Code No. NamePacking
size[ ]
Counter ion Typical ApplicationBase material Functionalgroup
Pore size[nm] pH range
Meanparticle size
[μm]
1-037-01
1-039-01
CQK30P
CQK31P
100
100
Na+
Na+
30
30
HMA
HMA
SP
CM
1~13
>4
60
60
Proteins
Proteins
Proteins
Proteins
1-034-01
1-034-02
SCK01
SCK01
5
10
H+ 11 Cation analysisST/DVB RSO3- 25
1-133-01
1-133-02
SCA04
SCA04
5
10
Cl- 5 Anion analysisHMA QA 30
●Ion exchange chromatography anion exchange resins[CA series, CDR series]
1-104-011-104-021-104-03
1-109-011-109-021-109-03
1-111-011-111-02
1-112-01
1-113-01
1-116-011-116-021-116-03
1-119-011-119-02
CA06SCA06SCA06S
CA08SCA08SCA08S
CA08FCA08F
CA08Y
CA08P
CA10SCA10SCA10S
CDR10CDR10
102550
102550
510
50
100
102550
714
Cl-
Cl-
Cl-
Cl-
Cl-
Cl-
Cl-
11
11
7
25
120
11
7
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Sugars, Carboxylic acids
Nucleic acids, Sugars
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
ST/DVB
QA
QA
QA
QA
QA
QA
QA
6
8
8
8
8
10
−
>1.2
>1.2
>1.2
>1.2
>1.3
>1.2
>0.3
Abbreviations; ST/DVB=styrene-divinyl benzene copolymer QA;Quaternary ammonium
Code No. NamePacking
size[g]
Counter ion Typical ApplicationBase material Functionalgroup
Crosslinkage
[%]
Meanparticle size
[μm]
Ion exchangecapacity
Abbreviation; HMA = Polyhydroxymethacrylate
●Bioseparation columns -Size exclusion chromatography materials- [CQP series]
1-222-01 CQP30P 100 30 Water soluble polymerHMA 1×10660
Code No. Name Typical ApplicationBase material Pore size[nm]
Exclusionlimit
Meanparticle size
[μm]
Packingsize[ ]
[ ]
Ion exchangecapacity[μeq/g]
●Analytical and preparative chromatography materials for pharmaceutical applications[CHP material series]
●Synthetic adsorbent and reversed-phase materials
●Chelating resins for solid phase extraction in pretreatment
Abbreviations; MA=Polymethacrylate ST/DVB=Styrene-divinylbenzene copolymer
Packingsize[ ]
1-315-021-316-021-505-02
CHP85/P120CHP87/P120CHPOD/P30
Meanparticle size
[μm]
MiddleSmallLarge
Small molecules extraction
Small molecules extraction
12012030
Full rangeFull range
2~121-219-01
1-317-01
CSP800
SFP08/P25
Middle
Middle
120
25
100mL100mL100g
50mL
50g
Full range
Full range
pH range Typical ApplicationCode No. Product Name Pore sizePacking size
Meanparticle size
[μm]Pore size[nm] pH range Typical ApplicationCode No. Product Name Base
material
10 25 2~12 Reversed-phasechromatography
1-309-011-309-03
CMG20/P10CMG20/P10
MA10g1,000
50 45 full range Reversed-phasechromatography
1-310-01 CHP20/P50 ST/DVB100g
120 45 full range Reversed-phasechromatography
1-311-011-311-021-311-031-311-041-311-05
CHP20/P120CHP20/P120CHP20/P120CHP20/P120CHP20/P120
ST/DVB100500
1,00010,00050,000
20 45 full range Reversed-phasechromatography
1-307-061-307-071-307-08
CHP20/P20CHP20/P20CHP20/P20
ST/DVB25100
1,000
10 25 full range Reversed-phasechromatography
1-312-011-312-03
CSP50/P10CSP50/P10
ST/DVB10g1,000
30 25 2~12 Reversed-phasechromatography
1-306-061-306-071-306-08
CMG20/P30CMG20/P30CMG20/P30
MA25100
1,000
30 25 full range Reversed-phasechromatography
1-303-061-303-071-303-08
CHP50/P30CHP50/P30CHP50/P30
ST/DVB25100
1,000
20 25 full range Reversed-phasechromatography
1-304-061-304-071-304-08
CHP50/P20CHP50/P20CHP50/P20
ST/DVB25100
1,000
70 45 full range Reversed-phasechromatography
1-313-021-313-031-313-04
CHP20/P70CHP20/P70CHP20/P70
ST/DVB5001,000
10,000
30 45 full range Reversed-phasechromatography
1-305-061-305-071-305-08
CHP20/P30CHP20/P30CHP20/P30
ST/DVB25100
1,000
120 25 full range Reversed-phasechromatography1-314-03
1-314-041-314-05
1-314-02CHP07/P120CHP07/P120CHP07/P120
CHP07/P120 ST/DVB1,000
10,00050,000
100
1-308-031-308-041-308-05
CMG20/P150CMG20/P150CMG20/P150
1,00010,00050,000
150 25 2~12 Reversed-phasechromatography
1-308-02 CMG20/P150 MA100
Enrichment of trace of organic compounds
1-601-021-602-021-603-02
CHL10PCHL20PCLB10P
Functionalgroup
120120120
Metal ExtractionMetal ExtractionBron Removal
Iminodiacetic acidPolyamineGlucamine
>1.5>1.8>1.0
100g100g100g
Excangecapacity Typical ApplicationCode No. Product Name Particle sizePacking size
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
65 66
123456789
101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960
Acetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidN-AcetylgalactosamineN-AcetylglucosamineAcetyl-D-Met.Acetyl-L-Met.AdenineAdenineAdenineAdenosineAdenosineAdenosineAdonitol5'-ADPAlanineAlanineβ-AlanineD-AlanineD-AlanineL-AlanineL-Alanineγ-Aminobutyric acid6-Aminopenicillanic acidAmmoniaAmmonium ionAmmonium ionAmmonium ion2'-AMP2'-AMP3'-AMP5'-AMP5'-AMPAMPAmphotericin BAngiotensin IIAntipyrineArginineAscorbic acidAspartic acidD-Aspartic acidD-Aspartic acidL-Aspartic acidL-Aspartic acidAspirin5'-ATPBarium ionBromide ionBromide ionBuserelinBuserelinn-Butyl alcoholsec-Butyl alcoholCadmium ionCaffeineCaffeine
Acetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidN-AcetylgalactosamineN-AcetylglucosamineAcetyl-D-Met.Acetyl-L-Met.Nucleic baseNucleic baseNucleic baseNucleosideNucleosideNucleosideAdonitolNucleotideAlanineAmino acidβ-AlanineD-AlanineD-Amino acidL-AlanineL-Amino acidγ-Aminobutyric acid6-Aminopenicillanic acidAmmoniaCationCationCationNucleotideNucleotideNucleotideNucleotideNucleotideNucleotideAmphotericin BAngiotensin IIAntipyrineArginineCarboxylic acidAspartic acidD-Aspartic acidD-Amino acidL-Aspartic acidL-Amino acidAspirinNucleotideBarium ionBromide ionBromide ionBuserelinBuserelinn-Butyl alcoholsec-Butyl alcoholCadmium ionCaffeineCaffeine
CK08EHCK08EHCK08EHCA08FCA08FCA08FCA08FCK08EHCK08EHCRS10WCRS10WCDR10CHK40/C04CHK45/C05SCK01CHK40/C04CHK45/C05CK08ECCDR10CK10UCK10UCK10UCRS10W/CRS15WCRS10WCRS10W/CRS15WCRS10WCK10UCHP50/P20SCK01SCK01SCK01CHK45/C05CDR10CDR10CDR10CDR10CDR10CHK45/C05CHP20/C10CMG20/C04 CMG20/C04CK10UCA08FCK10UCRS10WCRS10WCRS10WCRS10WCMG20/C04CDR10SCK01SCA04SCA04CHP20/C10CMG20/C10CK08EHCK08EHSCK01CHP20/C04CMG20/C04
2-132-162-182-392-402-412-422-142-146-146-142-435-255-333-65-255-332-12-432-322-362-336-216-196-216-192-345-353-23-13-33-102-432-442-442-432-445-335-175-125-102-322-412-326-56-156-56-155-102-433-73-113-125-225-222-152-153-85-45-10
11121219202020111156562145482445487
211718185857585718502424242521212121214841403917201755565556392125262644441111253639
Classification MCI GEL™ column Figure PageCompound
10 Compounds index616263646566676869707172737475767778798081828384858687888990919293949596979899
100101102103104105106107108109110111112113114115116117118119120121122123124125
5025252525475227501922242626262727121237404236111920212121212542385221172445482145483240424637381922565656501212123652243936503650
CaffeineCalcium ionCalcium ionCalcium ionCalcium ionCandesartanCapsaicinCarbonate ionCatechinCellobioseCellobioseCesium ionChloride ionChloride ionChloride ionChloride ionChloride ionChloroacetic acidChloroacetic acidCholic acidα-Chymotrypsinogen Aα-Chymotrypsinogen ACinchonineCitric acidCitric acidCitric acid2'-CMP3'-CMP5'-CMP5'-CMPCobalt ionConalbuminCorticosteroneCrocin3',5'-Cyclic AMPCystineCytidineCytidineCytidineCytosineCytosineCytosineCytochrome cCytochrome cCytochrome cβ-CitronelloolDeoxycholic acid11-DeoxycortisolDeoxyriboseDeoxyriboseD,D-2,6-Diaminopimelic acidL,L-2,6-Diaminopimelic acidmeso-2,6-Diaminopimelic acidDibutyl phthalateDichloroacetic acidDichloroacetic acidDiethylene glycolDiethyl phthalateDihydrocapsaicinDimethylamine4-DimethylaminoantipyrineDimethyl phthalateDimethyl phthalateDipropyl phthalateDipropyl phthalate
CaffeineCalcium ionCalcium ionCalcium ionCationCandesartanAlkaloidCarbonate ionCatechinCellobioseCellobioseCationAnionAnionAnionAnionAnionCarboxylic acidCarboxylic acidBile acidProteinProteinCinchona alkaloidCarboxylic acidCarboxylic acidCarboxylic acidNucleotideNucleotideNucleotideNucleotideCationProteinAdrenal cortical hormone CrocinNucleotideAmino acidNucleosideNucleosideNucleosideNucleic baseNucleic baseNucleic baseProteinProteinProteinPerfumeBile acidAdrenal cortical hormoneDeoxysugarDeoxysugarD,D-Diamino carboxylic acidL,L-Diamino carboxylic acidmeso-Diamino carboxylic acidAromatic esterCarboxylic acidCarboxylic acidPolyalcoholAromatic esterAlkaloidAmineMedicineAromatic esterAromatic esterAromatic esterAromatic ester
CHP50/P20SCK01SCK01SCK01CHK45/C05CHK40/C04CMG20/C10SCA04CHP50/P20CA08FCDR10SCK01SCA04SCA04SCA04SCA04SCA04CK08EHCK08EHCHP20/C04CMG20/C04CMG20/C10CHP20/C04CK08EHCA08FCA08FCDR10CDR10CDR10CDR10SCK01CHP20/C10CHP20/C04CMG20/P30CDR10CK10USCK01CHK40/C04CHK45/C05CDR10CHK40/C04CHK45/C05CQP30CMG20/C04CMG20/C10CMG20/C10CHP20/C04CHP20/C04CA08FCDR10CRS10WCRS10WCRS10WCHP50/P20CK08EHCK08EHCK08EHCHP20/C04CMG20/C10SCK01CMG20/C04CHP20/C04CHP50/P20CHP20/C04CHP50/P20
5-363-73-83-93-105-285-403-145-362-382-453-13-113-123-133-143-162-162-185-75-135-185-52-132-392-402-442-442-432-443-85-195-95-392-432-323-65-255-332-435-255-334-65-135-185-265-75-92-382-456-166-166-165-342-162-182-175-35-403-25-105-35-345-35-34
Classification MCI GEL™ column Figure PageCompound
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7 7 7 7 7 7 7 7 7
9
1
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10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
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1
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7
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1
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1
2
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6
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8
9
1
2
3
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9
1
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9
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1
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10 10 10 10 10 10 10 10
1
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9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
67 68
126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190
3650505050368997
55558
119
111232412626111920778888899
10161616192216197
10121922504879
464343202032778888899
DopamineEpicatechinEpicatechin gallateEpigallocatechinEpigallocatechin gallateEpinephrineErythritolErythritolErythritolmeso-ErythritolD-EthionineL-EthionineEthyl alcoholEthyl alcoholEthyl alcoholEthylene glycolEthylene glycolFerritinFilipinFluoride ionFluoride ionFormic acidFormic acidFormic acidFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructo-oligosaccharideFucoseGalactoseGalactoseGalactoseGalactoseGalactoseGallocatechinGDPGentiobioseGentiobioseGeraniolGhrelin humanGhrelin ratGluconic acidGluconic acidGluconic acidGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucose
CatecholamineCatecholCatecholCatecholCatecholCatecholamineSugar alcoholSugar alcoholSugar alcoholSugar alcoholD-Amino acidL-Amino acidAlcoholAlcoholAlcoholPolyalcoholPolyalcoholProteinAntibioticAnionAnionCarboxylic acidCarboxylic acidCarboxylic acidSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarFructo-oligosaccharideSugarSugarSugarSugarSugarSugarCatecholNucleotideDisaccharideDisaccharidePerfumePeptidePeptideCarboxylic acidCarboxylic acidCarboxylic acidSugarSugarSugarSugarSugarSugarSugarSugarSugar
CHP20/C04CHP50/P20CHP50/P20CHP50/P20CHP50/P20CHP20/C04CK08ECCK08ECCK08ECCK08ECCRS10WCRS10WCK08ECCK08EHCK08ECCK08EHCK08EHCQP30CHP20/C10SCA04SCA04CK08EHCA08FCA08FCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK04SCK04SCK04SCA08FCDR10CK04SCA08FCK08ECCK08ECCK06SCCA08FCDR10CHP50/P20CHK45/C05CK08ECCK08ECCMG20/C10CMG20/C10CMG20/C10CA08FCA08FCQP06CK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08EC
5-25-365-365-365-365-22-82-92-102-16-26-22-82-152-92-152-174-65-173-113-122-132-392-412-12-22-42-52-62-72-82-92-102-112-282-292-302-382-452-302-382-32-112-192-382-455-365-332-12-105-265-215-212-402-424-72-12-22-42-52-62-72-82-92-10
Classification MCI GEL™ column Figure PageCompound191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255
1011161616192232175555
89
11171112384021212124454548481755553030183836575757571857575757575757571837454821454843434343471718545454
GlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlutamic acidD-Glutamic acidL-Glutamic acidGlycerolGlycerolGlycerolGlycineGlycolic acidGlycolic acidGlycyrrhizic acidGly-Tyr3'-GMP5'-GMP5'-GTPGuanosineGuanosineGuanosineGuanosineGuanosineHistidineD-HistidineL-HistidineHemoglobin A0Hemoglobin A1c5-HPAHydrocortisone5-HydroxytryptophanD-2-Hydroxy-n-butyric acidL-2-Hydroxy-n-butyric acidD-α-Hydroxy isocaproic acidL-α-Hydroxy isocaproic acid5-hydroxy lysineD-α-Hydroxy-n-valeric acidL-α-Hydroxy-n-valeric acidD-m-Hydroxymandelic acidL-m-Hydroxymandelic acidD-p-Hydroxymandelic acidL-p-Hydroxymandelic acidD-P-Hydroxy phenylglycineL-P-Hydroxy phenylglycineHydroxy prolineHypoxanthineHypoxanthineHypoxanthine5'-IMPInosineInosineInsulin human recombinantInsulin glargineInsulin human recombinantInsulin glargineIrbesartanIsoleucineIsoleucineD-IsoleucineL-Isoleucineallo-D-Isoleucine
SugarSugarSugarSugarSugarSugarSugarSugarAmino acidD-Amino acidL-Amino acidPolyalcoholPolyalcoholPolyalcoholAmino acidCarboxylic acidCarboxylic acidGlycyrrhizic acidPeptideNucleotideNucleotideNucleotideNucleosideNucleosideNucleosideNucleosideNucleosideAmino acidD-Amino acidL-Amino acidProteinProteinAmino acidAdrenal cortical hormoneAmino acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidAmino acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-Amino acidL-Amino acidAmino acid6-HydroxypurineNucleic baseNucleic baseNucleotideNucleosideNucleosidePeptidePeptidePeptidePeptideSartanAmino acidAmino acidD-Amino acidL-Amino acidD-Amino acid
CK08ECK08EHCK04SCK04SCK04SCA08FCDR10CQP06CK10UCRS10WCRS10WCK08ECCK08ECCK08EHCK10UCK08EHCK08EHCHP20/C04CMG20/C04CDR10CDR10CDR10SCK01CHK40/C04CHK40/C04CHK45/C05CHK45/C05CK10UCRS10WCRS10WSP01SP01CK10UCHP20/C04CHP20/C04CRS10WCRS10WCRS10WCRS10WCK10UCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WCK10UCHP20/C04CHK40/C04CHK45/C05CDR10CHK40/C04CHK45/C05CHP20/C10CHP20/C10CMG20/C10CMG20/C10CHK40/C04CK10UCK10UCRS10WCRS10WCRS10W
2-122-142-282-292-302-382-454-72-326-66-62-82-92-152-322-132-185-85-122-442-442-433-65-255-255-335-332-326-76-74-24-22-355-95-26-176-176-176-172-376-176-176-186-186-186-186-206-202-355-65-255-332-445-255-335-205-205-205-205-282-322-366-16-16-1
Classification MCI GEL™ column Figure PageCompound
2
3
4
5
6
8
9
10
1
3
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6
8
9
10
1
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10
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10
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8 8
9
10
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10
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10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
69 70
256257258259260261262263264265266267268269270271272273274275276277278279280281282283284285286287288289290291292293294295296297298299300301302303304305306307308309310311312313314315316317318319320
541130111920205555575758584277
12192297
1217181855554044444444444446464624254717185555252525111920111919221010575725789979
allo-L-IsoleucineIsopropyl alcoholKinaseLactic acidLactic acidLactic acidLactic acidD-Lactic acidL-Lactic acidD-Lactic acidL-Lactic acidD-Lactic acidL-Lactic acidβ-LactoglobulinLactoseLactoseLactoseLactoseLactoseLactose monohydrateLactuloseLactuloseLeucineLeucineNor-LeucineD-LeucineL-LeucineLeu-EnkephalinLeuprorelinLeuprorelinLH-RH humanLH-RH humanLH-RH salmonLH-RH salmonLinaloolLinaloolLinalyl acetateLithium ionLithium ionLosartanLysineLysineD-LysineL-LysineMagnesium ionMagnesium ionMagnesium ionMalic acidMalic acidMalic acidMalonic acidMalonic acidMaltoseMaltoseMaltoseMaltotrioseD-Mandelic acidL-Mandelic acidManganese ionMannitolMannitolMannitolMannitolMannoseMannose
L-Amino acidAlcoholEnzymeCarboxylic acidCarboxylic acidCarboxylic acidCarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidProteinDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideAmino acidAmino acidAmino acidD-Amino acidL-Amino acidPeptidePeptidePeptidePeptidePeptidePeptidePeptidePerfumePerfumePerfumeCationCationSartanAmino acidAmino acidD-Amino acidL-Amino acidCationCationCationCarboxylic acidCarboxylic acidCarboxylic acidCarboxylic acidCarboxylic acidDisaccharideDisaccharideDisaccharideDisaccharideD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidCationSugar alcoholSugar alcoholSugar alcoholSugar alcoholSugarSugar
CRS10WCK08EHDA01CK08EHCA08FCA08FCA08FCRS10WCRS10WCRS10WCRS10WCRS10W/CRS15WCRS10W/CRS15WCMG20/C10CK08ECCK08ECCK06SCCA08FCDR10CK08ECCK08ECCK06SCCK10UCK10UCK10UCRS10WCRS10WCMG20/C04CHP20/C10CMG20/C10CHP20/C10CMG20/C10CHP20/C10CMG20/C10CMG20/C10CMG20/C10CMG20/C10SCK01CHK45/C05CHK40/C04CK10UCK10UCRS10WCRS10WSCK01SCK01CHK45/C05CK08EHCA08FCA08FCK08EHCA08FCA08FCDR10CK08ECK08ECRS10WCRS10WSCK01CK08ECCK08ECCK08ECCK08ECCK08ECCK08EC
6-12-154-32-132-392-412-426-116-116-176-176-226-225-182-12-32-192-382-452-102-32-192-322-362-366-26-25-125-225-225-225-225-225-225-265-275-263-13-105-282-322-376-86-83-73-93-102-132-392-412-132-392-382-452-122-126-186-183-82-12-82-92-102-12-10
Classification MCI GEL™ column Figure PageCompound321322323324325326327328329330331332333334335336337338339340341342343344345346347348349350351352353354355356357358359360361362363364365366367368369370371372373374375376377378379380381382383384385
1922192240175555565611241841324626262627272626555555554115151515161616183732113232325050391718555555555656261847472424242425414040
MannoseMannoseMelibioseMelibioseMet-EnkephalinMethionineD-MethionineL-MethionineD-MethionineL-MethionineMethyl alcoholMethylamineγ-methyl leuicineMevastatinMyoglobinNerolNitrate ionNitrate ionNitrate ionNitrate ionNitrate ionNitrate ionNitrate ionD-NorleucineL-NorleucineD-NorvalineL-NorvalineNystatinOligosaccharideOligosaccharideOligosaccharideOligosaccharideOligosaccharideOligosaccharideOligosaccharideOrnithineOrotic acidOvalbuminOxalic acidPEG MW 145,000PEG MW 40,000PEG MW 6,000Penicillin GPenicillin VPhenacetinPhenylalaninePhenylalanineD-PhenylalanineL-PhenylalanineD-PhenylalanineL-PhenylalanineD-α-PhenylglycineL-α-PhenylglycinePhosphate ionPipecolic acidPolyphenon 60Polyphenon 60Potassium ionPotassium ionPotassium ionPotassium ionPotassium ionPravastatin NaProcainamideProcaine
SugarSugarDisaccharideDisaccharidePeptideAmino acidD-Amino acidL-Amino acidD-Amino acidL-Amino acidAlcoholAmineAmino acidMedicineProteinPerfumeAnionAnionAnionAnionAnionAnionAnionD-Amino acidL-Amino acidD-Amino acidL-Amino acidAntibioticDp1-Dp9Dp1-Dp13Dp1-Dp16Dp1-Dp20Dp1-Dp7Dp1-Dp7Dp1-Dp7Amino acidCarboxylic acidProteinCarboxylic acidPEGPEGPEGAntibioticAntibioticMedicineAmino acidAmino acidD-Amino acidL-Amino acidD-Amino acidL-Amino acidD-Amino acidL-Amino acidAnionAmino acidPolyphenolPolyphenolCationCationCationCationCationMedicineAnestheticAnesthetic
CA08FCDR10CA08FCDR10CMG20/C04CK10UCRS10WCRS10WCRS10WCRS10WCK08EHSCK01CK10UCHP20/C10CQP30CMG20/C10SCA04SCA04SCA04SCA04SCA04SCA04SCA04CRS10WCRS10WCRS10WCRS10WCHP20/C10CK04SCK04SSCK02ACK02ASCK04SCK04SSCK02ASCK10UCHP20/C04CQP30CK08EHCQP30CQP30CQP30CHP50/P20CHP50/P20CMG20/C04CK10UCK10UCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WSCA04CK10UCHP07/C04CHP20/C04SCK01SCK01SCK01SCK01CHK45/C05CHP20/C10CMG20/C04CMG20/C04
2-382-452-382-455-122-326-36-36-146-142-153-22-365-164-65-263-113-123-133-143-163-113-126-36-36-36-35-172-212-222-232-242-252-262-272-375-64-62-134-54-54-55-355-355-102-322-376-26-26-96-96-136-133-112-355-295-303-13-33-43-53-105-165-145-14
Classification MCI GEL™ column Figure PageCompound
2
3
4
5
6
8
9
10
1
3
4
5
6
8
9
10
1
2
4
5
6
8
9
10
1
2
3
5
6
8
9
10
1
2
3
4
6
8
9
10
1
2
3
4
5
8 8
9
10
1
2
3
4
5
6
9 9
10
1
2
3
4
5
6
10 10
1
2
3
4
5
6
8
1
2
3
4
5
6
8
7 7 7 7 7 7 7 7 7
9
1
2
3
4
5
6
8
7
9
10
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
71 72
386387388389390391392393394395396397398399400401402403404405406407408409410411412413414415416417418419420421422423424425426427428429430431432433434435436437438439440441442443444445446447448449450
1718555511203619229
40424279
1922302479
5151515151515117555536444124242424257
4579
25252039788
101626262639393911192018363637
ProlineProlineD-ProlineL-Prolinen-Propyl alcoholPyruvic acidQuinineRhamnoseRhamnoseRibitole(Adnitole)Ribonuclease ARibonuclease ARibonuclease ARiboseRiboseRiboseRiboseRituximabRubidium ionSalicinSalicinSennoside ASennoside BSennoside ASennoside BSennoside ASennoside BSennoside ASerineD-SerineL-SerineSerotoninSifuvirtideSimvastatinSodium ionSodium ionSodium ionSodium ionSodium ionSorbitolssRNAStachyoseStachyose hydrateStrontium ionStrontium ionSuccinic acidSuccinylsulfathiazoleSucroseSucroseSucroseSucroseSucroseSulfate ionSulfate ionSulfate ionSulfamerazineSulfanilamideSulfathiazoleTartaric acidTartaric acidTartaric acidTert-leuicineTheobromineTheophyllineTheophylline
Amino acidAmino acidD-Amino acidL-Amino acidAlcoholCarboxylic acidCinchona alkaloidSugarSugarSugar alcoholProteinProteinProteinSugarSugarSugarSugarMonoclonal antibodyCationPhenol glycosidePhenol glycosideSennoside ASennoside BSennoside ASennoside BSennoside ASennoside BSennoside AAmino acidD-Amino acidL-Amino acidCatecholaminePeptideMedicineCationCationCationCationCationSugar alcoholRNATetrasaccharideSugarCationCationCarboxylic acidSulfa drugDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideAnionAnionAnionSulfa drug Sulfa drug Sulfa drug Carboxylic acidCarboxylic acidCarboxylic acidAmino acidPurine alkaloidPurine alkaloidPurine alkaloid
CK10UCK10UCRS10WCRS10WCK08EHCA08FCHP20/C04CA08FCDR10CK08ECCMG20/C04CMG20/C10CHP20/C10CK08ECCK08ECCA08FCDR10SP01SCK01CK08ECCK08ECCHP20/C10CHP20/C10CHP20/P20CHP20/P20CHP20/P30CHP20/P30CHP20/P30CK10UCRS10WCRS10WCHP20/C04CMG20/C10CHP20/C10SCK01SCK01SCK01SCK01CHK45/C05CK08ECCHP20/C10CK08ECCK08ECSCK01SCK01CA08FCMG20/C04CK08ECCK08ECCK08ECCK08ECCK04SSCA04SCA04SCA04CMG20/C04CMG20/C04CMG20/C04CK08EHCA08FCA08FCK10UCHP20/C04CHP20/C04CHP20/C04
2-322-356-26-22-152-415-52-382-452-105-135-185-192-12-102-382-454-13-12-12-105-375-375-375-375-375-375-382-326-46-45-25-235-163-13-33-43-53-102-25-242-12-103-73-82-415-112-22-42-52-112-303-113-123-135-115-115-112-132-392-412-365-45-45-6
Classification MCI GEL™ column Figure PageCompound451452453454455456457458459460461462463464465466467468469470471472473474475476477478479480481482483484485486487488489490491492493494495496497498499500501502503504505506507508509510511512513514515
2727174548214553535353535353535353535353535353535353535353535353535353214212122448483655551718555521214821454837244548223717181855
Thiocyanic ionThiosulfuric ionThreonineThymidineThymidineThymineThymineD-α-TocopherolD-γ-TocopherolD-δ-TocopherolD-α-TocopherolD-γ-TocopherolD-δ-TocopherolD-α-TocopherolD-β-TocopherolD-γ-TocopherolD-δ-TocopherolD-α-TocopherolD-β-TocopherolD-γ-TocopherolD-δ-TocopherolD-α-TocopherolD-γ-TocopherolD-δ-TocopherolD-γ-TocotrienolD-γ-TocotrienolD-α-TocotrienolD-β-TocotrienolD-γ-TocotrienolD-δ-TocotrienolD-α-TocotrienolD-β-TocotrienolD-γ-TocotrienolD-δ-TocotrienolD-γ-TocotrienolTPNTransferrinTrichloroacetic acidTriethylene glycolTrimethylamineTritonX-100TritonX-100 TryptophanD-TryptophanL-TryptophanTyrosineTyrosineD-TyrosineL-Tyrosine3'-UMP5'-UMPUMPUracilUracilUracilUric acidUridineUridineUridineUrineUrsodeoxycholic acidValineValineValineD-Valine
AnionAnionAmino acidNucleosideNucleosideNucleic baseNucleic baseVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminVitaminNucleotideProteinCarboxylic acidPolyalcoholAmineSurfactantSurfactantAmino acidD-Amino acidL-Amino acidAmino acidAmino acidD-Amino acidL-Amino acidNucleotideNucleotideNucleotideNucleic baseNucleic baseNucleic base2,6,8-TrioxypurineNucleosideNucleosideNucleosideUrineBile acidAmino acidAmino acidAmino acidD-Amino acid
SCA04SCA04CK10UCHK40/C04CHK45/C05CDR10CHK40/C04CMG20/C04CMG20/C04CMG20/C04CMG20/P30CMG20/P30CMG20/P30CMG20/C04CMG20/C04CMG20/C04CMG20/C04CMG20/P150CMG20/P150CMG20/P150CMG20/P150CMG20/C10CMG20/C10CMG20/C10CMG20/C04CMG20/P30CMG20/C04CMG20/C04CMG20/C04CMG20/C04CMG20/P150CMG20/P150CMG20/P150CMG20/P150CMG20/C10CDR10CMG20/C10CK08EHCK08EHSCK01CHPOD/04ODS-1HUCHP20/C04CRS10WCRS10WCK10UCK10UCRS10WCRS10WCDR10CDR10CHK45/C05CDR10CHK40/C04CHK45/C05CHP20/C04SCK01CHK40/C04CHK45/C05CDR10CHP20/C04CK10UCK10UCK10UCRS10W
3-153-152-325-255-332-435-255-415-415-415-425-425-425-435-435-435-435-445-445-445-445-415-415-415-415-425-435-435-435-435-445-445-445-445-412-435-182-162-173-25-315-325-26-106-102-322-376-26-22-442-445-332-435-255-335-63-65-255-332-465-72-322-332-366-2
Classification MCI GEL™ column Figure PageCompound
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MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n list
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
SPE sorbent seriesIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Chiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
MCI GEL™ colum
n listChiral separationcolum
ns
SPE sorbent series
SPE sorbent series
SPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n list
SPE sorbent series
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsCom
pounds indexMCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
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カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
73 74
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Limited warranty
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�A�.
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�B�.
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�C�.
Conditions
�A�l�l� �s�p�e�c�i�f�i�c�a�t�i�o�n�s�,� �q�u�a�n�t�i�t�i�e�s�,� �d�e�s�i�g�n�s� �a�n�d� � �p�r�i�c�e�s� �a�r�e� �s�u�b�j�e�c�t� �t�o� �c�h�a�n�g�e� �w�i�t�h�o�u�t� �n�o�t�i�c�e�.
Changes
�N�e�i�t�h�e�r� �t�h�i�s� �p�u�b�l�i�c�a�t�i�o�n�,� �n�o�r� �a�n�y� �p�r�o�d�u�c�t�s� �i�n� �t�h�i�s� �b�r�o�c�h�u�r�e� �s�h�a�l�l� �b�e� �c�o�n�s�t�r�u�e�d� �a�s� �r�e�c�o�m�m�e�n�d�i�n�g� �t�h�e� �i�n�f�r�i�n�g�e�m�e�n�t� �o�f� �a�n�y� �p�a�t�e�n�t�,� �n�o�r� �e�x�t�e�n�d�i�n�g� �a�n�y� �l�i�c�e�n�s�e�,� �e�x�p�r�e�s�s� �o�r� �i�m�p�l�i�e�d�,� �n�o�r� �a�s�s�u�m�i�n�g� �a�n�y� �l�i�a�b�i�l�i�t�y� �u�n�d�e�r� �a�n�y� �i�s�s�u�e�d� �o�r� �p�e�n�d�i�n�n�g� �p�a�t�e�n�t�.� � �T�h�e� �d�a�t�a� �p�r�e�s�e�n�t�e�d� �h�e�r�e�i�n� �h�a�v�e� �b�e�e�n� �c�a�r�e�f�u�l�l�y� �c�o�m�p�i�l�e�d� �f�r�o�m� �o�u�r� �r�e�c�o�r�d�s� �w�h�i�c�h� �w�e� �b�e�l�i�e�v�e� �t�o� �b�e� �a�c�c�u�r�a�t�e� �a�n�d� �r�e�l�i�a�b�l�e�.� � �W�e� �m�a�k�e�,� �h�o�w�e�v�e�r�,� �n�o� �w�a�r�r�a�n�t�i�e�s� �o�r� �r�e�p�r�e�s�e�n�t�a�t�i�o�n�s� �w�i�t�h� �r�e�s�p�e�c�t� �h�e�r�e�t�o�,� �n�o�r� �i�s� �f�r�e�e�d�o�m� �f�r�o�m� �a�n�y� �p�a�t�e�n�t� �t�o� �b�e� �i�n�f�e�r�r�e�d�.
General
516517518519520521522523524525526527528529530531
554740404040374548484579
192225
L-ValineValsartanVitamin B3Vitamin B6Vitamin B12Vitamin CXanthineXanthineXanthineXanthine oxidaseXanthosineXylitolXylitolXyloseXyloseZinc ion
L-Amino acidSartanWater soluble vitaminWater soluble vitaminWater soluble vitaminWater soluble vitamin2,6-DihydroxypurineNucleic baseNucleic baseNucleic baseNucleosideSugar alcoholSugar alcoholSugarSugarCation
CRS10WCHK40/C04CMG20/C04CMG20/C04CMG20/C04CMG20/C04CHP20/C04CHK40/C04CHK45/C05CHK45/C05CHK40/C04CK08ECCK08ECCA08FCDR10SCK01
6-25-285-155-155-155-155-65-255-335-335-252-12-102-382-453-7
Classification MCI GEL™ column Figure PageCompound
SPE sorbent seriesChiral separationcolum
nsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
Compounds index
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
ns
Analytical and preparative chromatography columns and materials for pharm
aceutical applicationsMCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ material list
MCI GEL™ material list
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
SPE sorbent seriesChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Compounds index
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ colum
n listChiral separationcolum
nsAnalytical and preparative chromatography columns and materials for pharm
aceutical applications
Chiral separationcolum
nsSPE sorbent series
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
MCI GEL™ colum
n listBioseparation colum
ns and m
aterialsIon chrom
atography colum
ns and materials
Ion exchange columns
and materials
Column selection
guide
MCI GEL™ material list
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
Compounds index
MCI GEL™ material list
Bioseparation columns
and materials
Ion chromatography
columns and m
aterialsIon exchange colum
ns and m
aterialsColum
n selectionguide
Analytical and preparative chromatography columns and materials for pharm
aceutical applications
2
3
4
5
6
7
8
9
1
3
4
5
6
7
8
9
10 10
1
2
4
5
6
7
8
9
1
2
3
5
6
7
8
9
1
2
3
4
6
7
8
9
1
2
3
4
5
7
8
9
1
2
3
4
5
6
8
9
1
2
3
4
5
6
7
9 9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
1
2
3
4
5
6
7
8
1
2
3
4
5
6
7
8
9
10 10 10 10 10 10 10 10
1
2
3
4
5
6
9
10
11
カラム選択の手引き
イオン交換クロマトグラフィー用
充填カラム及び充填剤
イオンクロマトグラフィー用
充填カラム及び充填剤
生体高分子分離用
充填カラム及び充填剤
医薬精密精製用充填カラム
及び充填剤
アミノ酸DL分離用
充填カラム
MCI
GEL
カラム一覧
MCI
GEL
充填剤一覧
分離例化合物リスト
7
固相吸着剤
75