c o n f i d e n t i a l

EVOLUTION Advanced Brain Training

for a Fit & Healthy Brain

4

The way we use technology

changes our brains

5

It started with an idea

Victims of Depression, Stress, and Brain Injury need help They all suffer from damaged brain functions and reduced motivation and quality of life

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Lea, 18, student

Anja, 37, manager

“HELP ME… feel good again”

“HELP ME… get my abilities back”

Regain cognitive function is my priority

Help me… think straight again!

Help me… back to normal function!

Help me… I can’t do it myself!

Get back to 100% is my priority

Help me… regain my memory

Help me… to sort problems

Help me… to excess capacity

Depression

Stress

Dennis, 46, technician

“HELP ME… back to a normal life”

Getting my life back is my priority

Help me… function normally

Help me… to cope with my life!

Give me… get my brain back!

Brain injury

Source: Evolution users and focus groups in age groups 30-50, 50-80 by Evolution, 2012-2013

Health care professionals are looking for solutions They are overworked and under-resourced and lack innovative tools

Source: Interviews with Health Care Professionals from selected Danish Institutions and Centers

“There are many tools for physical rehabilitation,

but nothing really for higher cognitive functions”

“It pains me, but we really don’t have time

to help everyone

“We need tools that motivate the patients,

they have such a hard time focusing”

“There are some tools, but I’m afraid there

are not many good solutions specifically

for the victims of depression and stress”

A Fit and Healthy Brain is in high demand

8 Source: Brain+ users and focus groups in age groups 30-50, 50-80 by Brain+, 2012-2013

Maria, 32, consultant

Trine, 45, manager

“HELP ME… be a high performer”

“HELP ME… stay fit and healthy”

Success in life is my priority

Help me… to get ahead in life!

Help me… live smarter!

Help me… save time!

Fitness and health is my priority

Help me… stay young!

Help me… cope with my life!

Give me… a break with a purpose!

Sporty Performer

Health Conscious

A Fit and Healthy Brain is in high demand

9 Source: Brain+ users and focus groups in age groups 30-50, 50-80 by Brain+, 2012-2013

My child’s success is my priority

My child is special, help make it so!

Help my child… do well in school!

Teach my child… special skills!

Staying healthy is my priority

Help me… protect my memory!

Help me… live a full life!

Help me… stay active all my life!

Caring Parent

Older active “HELP ME… protect my mind”

Eric, 71, retired engineer

Trine, 45, working mother

“HELP ME… help my child

Depression - 400 million yearly cases – a leading cause of disability Responsible for 6% of the total global disease burden (DALYs)(1)

1) Disability adjusted life years Source: WHO, CDC, IHME, WebMD, NCBI, Sygeplejersken nr32/2004 10

400

0

50

100

150

200

250

300

350

400

450

Depression cases worldwide (# million)

Massive costs to individuals and society

US

• 9% of US adults are occasionally depressed

• 3.4% of US adults suffer from major depression

Europe

• 21 million (of 466) people affected (4.5%)

• €118 Billion total annual cost estimated

• Most costly brain disorder

• Accounts for 33% of the total cost

• This equals 1% of total GDP in Europe

Only 60-70% respond well to psychotherapeutic or medicinal treatments

Wide and Severe Cognitive Impairments related to Depression

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1) Studies have shown that depressed patients on average have 7-15% smaller frontal lopes than control groups Sources: Ravnkilde et al. 2002, Austin et al. 2001, Veiel, 1997, Mialet et al. 1996, Burt et al. 1995, Sobin and Sackeim, 1997, Channon and Green, 1999. Paradiso et al. 1997; Kessing, 1998, Videbech, 1997, Kessing, 1998, Elkis et al. 1995

• Atrophy of pre-frontal cortex(1)

• Atrophy of hippocampus

• Atrophy of basal ganglia

• White matter lesions

• Silent infarcts

• Basic perceptual functional deficits

• Complex higher functional deficits

Physiological & Cognitive Impact

• Severe stress

• Concentration and focus

• Memory functions

• Learning capacity

• Psychomotor tempo

• Planning

• Task initiation & monitoring

• Increased dementia risk

• Psychological, mood, self-esteem

Serious Functional & Emotional deficits

Cognitive deficits persist after the clinical depression and worsen with relapses

Being depressed once gives 50% chance of relapse, depressed twice 80% chance

Massive need also exists in recovery of brain injury & disease

21.7

20.8

42.5 9.0

10.0 19.0

0

20

40

60

80 Cases worldwide, 2011 (# million)

Additional

prevalence

Incidence1

Total

62

Trauma2

31

Stroke

31

1: New cases per year 2. Total number of cases as bibliography, incidence vs. rest of prevalence split calculated as in the European case Source: European Neuropsychopharmacology (2011), NeuroRehabilitation. 2007;22, Brain Injury Statistics, Brain injury association of America; Family caregiver alliance in the US

Traumatic Brain Injury & Strokes Dementia

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36

66

115

0

20

40

60

80

100

120

140

2010 2030 2050

Cases worldwide (# million)

Resulting in heavy Health Care (HC) cost

burden

• US ~$130bn/year

• EU ~€100 bn/year

HC cost of dementia care in Europe of ~60 bn€

• Plus ~€129 bn hidden in informal care costs

• Plus ~€220 M in productivity loss

Self improvement, Mobile-Health, and Mental Well-being megatrends

drive people seek ways to improve, measure, and track

“body tracking taking off…

in medical and lifestyle.”

83%

‘Adults of all ages should take

charge of their own brain

fitness’

1) Mark Smith, quantified self pioneer Source: TrendWatching, SharpBrains Survey, 2012,

A young, yet rapidly growing market for digital brain training, $6.3 billion in

2020 Initial go-to-market focus is on the B2C segment

1) Compound Annual Growth Rate Source: SharpBrains Market Report 2012

500

3.250

1.800

600

500

0

1000

2000

3000

4000

5000

6000

7000

2005 2012 2020

Employers

School Systems

Health care, Senior Living, Insurance Providers

Consumers

6.250

1.080

210

Customer segments

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Revenues (million USD)

Digital Brain Training Market

CAGR1 25%

Neuroscience is discovering potential for lifelong cognitive improvements

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“One can improve cognitive speed of processing by 146-250 percent”

“People as old as 80, attain neurological patterns and levels

beyond that of untrained 20 year olds”

“We have found no ceiling for abilities such as attention”

“Significant gains in auditory processing and auditory memory

equivalent to ten years of aging for that skill”

Dr. Michael Merzenich et al., Extended study 2007, Dr. Elizabeth Zelinsky, et. Al.

MD, PhD. Adam Gazzaley, Director, UCSF Neuroscience imaging Center

Dr. Michael I. Posner, Emeritus Professor of Neuroscience, University of Michigan

Dr. Jerri Edwards, Associate Professor, University of South Florida’s School of Aging Studies

First-person shooter training studies find functional improvements

Function improved Published scientific studies

Attentional blink Green & Bavelier, 2003, Cohen, Green & Bavelier, 2007; Oei & Patterson,

2013

Change detection Oei & Patterson, 2013

Cognitive control Oei & Patterson, 2013

Crowding Green & Bavelier, 2007

Enumeration Green & Bavelier, 2003, Cohen, Green & Bavelier, 2006

Mental rotation Feng, Spence & Pratt, 2007

Multiple object tracking Cohen, Green & Bavelier, 2007; Green & Bavelier, 2006,

Speed of processing Green, Poughet & Bavelier, 2010

Task switching Green et al, 2012

Useful field of view Green & Bavelier, 2003, Feng, Spence & Pratt, 2007

Visual acuity Li, Ngo, Nguyen & Levi, 2011

Visiospatial imagery Sanchez

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Science fact!

or

Science fiction?

Some main stream brain training products for healthy people exist,

but lack scientific base and gamification (long term user motivation)

Source: (Left) Lumosity, San Francisco Business Times (Right) Rabipour, 2012, Evolution Analysis

0.2 3 10

22

34

60

0

10

20

30

40

50

60

70

2009 2010 2011 2012 2013 2014

Install base (# million)

Lacking scientific foundations

Lacking proof of effect

Non-motivating sterile

test-exercise paradigms

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The Market’s Elephant The Lumosity look-a-likes

The old fashioned guard

Elevate

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There was a gap

that we set out to fill

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Create Global Quantum Leap in Brain Performance &

Health

Vision

Founders with unique competence mix from industry, gaming & science Team (I)

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Kim Baden-Kristensen

Founder & CEO

13 years

Leadership

Strategy

Marketing

Sales

Cognitive Psychology

Vice President

Project Leader

Product Manager

Rasmus Højengaard

Founder & CCO

17 years

Game Direction

Game Development

Software Development

Art Direction

Marketing & Sales

Global Creative Director

Senior Producer

Game Director

Ulrik Ditlev Eriksen

Founder & COO

11 years

Strategy

Entrepreneurship

Innovation & Bus. Dev.

Financing

Sales & Marketing

Cognitive Psychology

Danventures & Swirlnet

Director

Vice President

Partner

3 year collaboration with leading Danish neuroscientists Team (II)

29 years, Authority figure in neural and cognitive plasticity and brain injury

rehabilitation

100+ publications. Head of Unit for Cognitive Cognitive Neuroscience, at University of

CPH; Board chair and member of a number of key rehabilitation institutions.

30 years, Cognitive Psychologist,

Head of Brain Rehabilitation, Advanced Technology and Learning lab (BratLab)

W. extensive business experience;; Corporate IT Director at Satair A/S; Global Director

at IBM

32 years, Dr. Med, Neurological Clinic, Danish National Hospital

Clinical Professor Of Cerebrovascular Diseases, in depth knowledge of clinical

health care system; 100+ publications

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Jesper Mogensen

Professor, Scientific Leader

Inge Wilms

Postdoc – Science Manager

Derk Krieger

Chairman of Advisory Board

Core science team

Wi th t h e B ra i n + Ap p v1 .0 , SC IEN C E . . . m e t EN TER TA IN MENT

Improved Attention

Better Memory

Sharper Problem Solving

Scientifically designed cognitive training

games

+

The Brain+ app (v1.0) is a success

Source: Itunes Connect, Apple App Store, Flurry user statistics, App Annie 24

1.050.000+ installs to date

Featured Best New App 150

countries

App Store ratings of 5 (out of 5)

500+ PR articles worldwide

Singapore New Zealand India

However, the success didn’t come easily

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Barriers to growth surfaced…

Resource constraints

Technology platform

IT & game development

competences

Money

…and stress

Partnered with Cape Copenhagen, world class game developers Team (III)

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Cape Copenhagen is household supplier for top global brands Team (III)

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Th e ®e vo l u t i ona ry n e w a p p

EVOLU TION B R A IN TR A IN IN G

Ge t r e a d y f o r

A 3 D jour ne y in the b r a in

R e l e a se

2 0 1 5

LIVE DEMO

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What is the future of neurogaming?

There are 2 important, but different uses of digital games

Games as fun with benefits

• Play for fun

• Added benefits of functional

improvements

• Entertainment with benefit

• Hours consumed are not

“wasted”

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Games as (therapeutic) tools

• Users play for the benefits

• Fun is a bonus

• Game mechanics and

psychology are means to:

• Motivate

• Create arousal

Application of digital brain tech covers the full disease spectrum

B2C:

Life stage/gender(1)

Senior / retired 67+

Adult (working) 26-67

Adult

(student/youth) 14-25

Child (parent) 2-13

Industry

Public sector

B2B-2C

Fitness, health &

performance Prevention Maintenance

Recovery &

Treatment

Avoid loss of ability Stabilize disease Most out of life Back to normal

Corporate

employee care

Education

learning

Social care

Social Care

Employee care

Social care

Pharma

Insurance

Health care

Pharma

Insurance

Health care

Healthy(1) Injury or Deficit

(1) Segmentation is further refined for marketing and sales activities, fx.“Wellness” or “Fitness” focus Source: Brain+ analysis

Man

Man

Man

Man

Woman

Woman

Woman

Woman

Man

Man

Man

Man

Woman

Woman

Woman

Woman

How games can become life changers

Direct functional impact

• A function is improved

• A skill is improved

• A symptom is alleviated

• A state of mind is changed

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Habit changing & educational

• New knowledge changed

behavior

• Meta-cognition + learning skills

• Facilitator of habit changes

• Structured process of change

• Motivation

• Incentives + rewards + Social

• Progress & adherence monitoring

• Lifestyle changes

• Sleep, stress, physical, dietary

Will a “digital pill” be the future of health care? Vast opportunity to decrease disease burden and improve outcomes

A Digital Pill…

• Digital & Drugs - Mind &

Body

• Holistic health

• Cognitive health assessment

• Diagnostics

• Early warning

• Prevention

• Adherence

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…to combat disease

• Depression

• Stress & PTSD

• Neurodegenerative

• Traumatic Brain Injury

• Diabetes

• ADHD

• Autism

Questions for discussion

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What is the single most important

user benefit we need to deliver

with neurogaming?

Questions for discussion

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What is the biggest barrier for

neurogaming’s positive impact?

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For all scientists and HC practitioners…

Work with us to discover how a tool like

Evolution benefits the brain and lives

kim@brain-plus.com