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EVENT GUIDE
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HIGHLIGHTS AND INFORMATION
WiFiWiFi is available throughout the Conference Area. Please log in to Hotel Westin, no password is required
POSTER PRESENTATIONS Posters will be available to view in the Exhibition Hall throughout the conference days. Please see page 7 for more details
INFORMATIONIf you have any queries throughout the event, please visit the registration desk and speak to a member of the Informa Connect staff
SECURITY AND BADGE SCANNINGWe may ask to scan your badge for security and monitoring purposes. Please note that when scanned by an exhibitor, the bar code on your badge allows the exhibitor to collect your contact details
which they will use to contact you for the purposes of event follow-up and to send you marketing information about their products and services. If you do not wish to share your contact information with the exhibitor for these purposes, please do not give the exhibitor permission to scan your badge.
PERSONAL BELONGINGSPlease always keep your valuables and working materials with you. We regret that neither Informa Connect nor the venue can be held responsible for any loss or damage to your property.
SPEAKER PRESENTATIONS Speaker presentations will be made available after the conference ends, accessible on the Networking App. We only load presentations that have been given permission by the speaker. Please allow a few days post conference for these to get loaded.To get the Networking App, simply download the ‘Informa Connect’ app, and search for “BioProcess International Asia / Cell Therapy Manufacturing Asia”Any questions, contact [email protected]
DRINKS RECEPTIONJoin our Networking Drinks Reception and enjoy canapes, drinks and origami taught by a specialistThursday 27th February 5:15-6:15 • Exhibition Hall
NETWORKING APPAll registered attendees will have access to the Networking App. This allows you to:• View the full attendee list• Send meeting requests•Build your profile
SPONSORSHIPFor sponsorship opportunities, please visit the Sales Office in the Exhibition Hall
Production - Catherine Simpson, Barry Walsh, Sarah LinternSponsorship - Perri Lucatello, Kristen Schott, Kristin Skahan, Jennifer WickettOperations - Roshni Shah, Hannah BrantMarketing - Howard Choi, Shahana ChowdhuryDelegate Sales - Jessica Purnell
PROJECT TEAM:
www.CellGeneEvent.com
September 21-24, 2020Boston Convention & Exhibition Center
Boston MA
THE CELL AND GENE THERAPY CONFERENCE FOR GROUND BREAKING BIOPROCESSING, MANUFACTURING & SUPPLY CHAIN STRATEGIES World renowned leaders share the latest technologies & commercialization techniques to revolutionize your cell, gene and CAR-T clinical and late stage programs
Part of Biotech Week
Boston
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HEALTH & SAFETY
The fire alarm sound in this building is a siren, bell and announcement.
If you discover a fire raise the alarm by pull station
Do not stop to collect your belongings or use lifts
Do not obstruct any exits or gangways
There is a no smoking policy at this event. Smoking will only be allowed outside of the venue in designated areas
Please make yourself aware of the emergency exits in your immediate area
The assembly point for this event is located at Reception (Lobby Area)
Should you require special assistance please tell a member of Informa Connect staff
Please be responsible when plugging laptop and mobile chargers into sockets
Data ProtectionDue to increased data protection legislation, we are now unable to distribute the contact details for the speakers and delegates attending our events. Should you wish to contact anyone who has attended today's event, please log into the PartneringOne App (details on page 5) or contact a member of staff at the registration desk. and we will be happy to pass on your details to the person you would like to contact.
Liability for lost or stolen itemsInforma Connect will not accept any liability for loss, theft, damage or delay resulting from the loss or theft of any item of property belonging to participants or authors or third party, and the authors and participants and third party agree that it is their responsibility to have in place adequate insurance to cover all such eventualities.
Notwithstanding the provisions of the above paragraph, in the event that such items are taken into the custody of Informa or its representatives, Informa will exercise reasonable care but its liability for any such item for loss, theft, damage or delay whilst in the care of Informa or its representatives will not exceed the value of any item or £1,000, whichever is the lower.
Informa Connect may make a reasonable charge for the return of lost or unclaimed property to the participant or author or third party depending upon:
1. the type of article; and
2. the period during which Informa has held the article before it is claimed.
DisclaimerAlthough the content of conference materials is believed to be accurate, neither Informa Connect nor its presenters make any representations or warranties regarding such content or materials. Please note that:- (a) anybody using or relying upon information or opinions set out in the conference materials, does so at their own risk; (b) Informa and its presenters strongly advise that independent professional judgment be exercised and/or independent professional advice should be sought before using or relying upon such information or opinions; and (c) some of the views and opinions expressed by presenters may be their own and may not necessarily represent the views or opinions of the companies or organisations by whom they are engaged or employed.by whom they are engaged or employed.
Stay Engaged Year-Round with BioProcess International
BioProcessInternationalUS West
March 9-12, 2020Santa Clara, California, USAwww.BioProcessWest.com
BioProcessInternationalAsia
February 26-28, 2020Kyoto, Japanwww.BioProcessAsia.com
BioProcessInternational
September 21-24, 2020Boston, Massachusetts, USAwww.BPIevent.com
October 13-15, 2020Milan, Italywww.BioProductionEvent.com
BioProductionPart of
BioProcessInternationalEurope
April 28-May 1, 2020RAI, Amsterdamwww.BioProcessEurope.com
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POSTER PRESENTATIONS
Posters can be viewed Thursday 07:15 - 18:15 and Friday 08:30-15:30
BIOPROCESSINGB1 Filtration Membranes are Scavengers for Leachables Shohei Sente Sartorius Stedim
Biotech
B2 Considerations on the Scaling and Combination of Extracables Data
Armin Hauk Sartorius Stedim Biotech
B3 Using Extractables for Material Safety Evaluation of Polyethersulfone Sterile Filters
Armin Hauk Sartorius Stedim Biotech
B4 Bioprocessing Data Aggregation Platform to Provide Easy Access from monitoring to Visualization and Analysis
Takao Ito Merck
B5 Process Understanding: The Single Most Valuable Asset in Bioprocessing
Thiemo Huuk Merck
B6 Inline concentration of mAb feed to increase the productivity of a continuous multi-column chromatography capture step
Takao Ito Merck
B7 Novel Perfusion Filter and Controller for N-1 Application Takao Ito Merck
B8 Purification of Antibody Fragments with Amsphere™ A3 Protein-A Resin
Makoto Higami JSR Corporation
B9 Nuvia aPrime 4A: A Hydrophobic Anion Exchange Resin for Refined Selectivity and Recovery
Koji Nakamura Bio-Rad
B10 Toshihiro Ogawa JSR Corporation
CELL AND GENE THERAPYC1 TBA Kazushige Sugama Albumedix Ltd
C2 Improvements in Post-freeze stability of clinical grade hMSC to solve logistical challanges of cell therapies
Poula Krogh Albumedix Ltd
C3 TBA Wilfred Germeraad Maastricht University
C4 Addressing Large-Scale Therapeutic Virus Production Using High Quality Grade PEI-based Transfection Reagents
Takashi Hara Polyplus-transfection
Join us for a comprehensive series of expert-led webcasts and useful resources to help you achieve success in the cell therapy and regenerative medicine fields.
2019 Sponsors:
4-DAY WEBCAST SERIES — April 20-23, 2020
Cell & Gene Therapy Manufacturing Digital Week
FREE WEBCASTS, LIVE Q&AS, VIDEOS, POSTERS, AND WHITE PAPERS!
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PRE-CONFERENCE SYMPOSIUM • WEDNESDAY, FEBRUARY 26, 2020
Room: Kiku
10:00 Registration and Morning Coffee
10:55 Chairperson’s Opening Remarks
CELL LINE DEVELOPMENT & ENGINEERING
11:00 Cell Line Development With High Titer And Long Term StabilitySungHo Hahm, CEO, Rophibio, Inc., South Korea
11:30 Accelerated High Performance Cell Line Development at SBL John Gill I.V, Director, Cell Line Development, Samsung Biologics, South Korea
12:00 Establishing A New Standard: Unparalleled Timeline Compression, Titer, and MonoclonalityKeith Breinlinger, Chief Technology Officer, Berkeley Lights, Inc.
12:30 Lunch and Networking
13:30 Use of Signal Peptides to Influence Quality of the Recombinant Proteins: A Case StudyJana Frank, Director of Cell Line Development, Canton Biologics, China
UPSTREAM PROCESSING
14:00 Driving Value Towards The Evolution Of Upstream Intensification With Perfused Seed TrainHabib Horry, Associate Director of Marketing - Upstream Process Integration - Next Generation BioProcessing, Merck Group, France
14:30 Monitoring the Scale-Up of a Biopharmaceutical Cell Culture Process Using Raman Spectroscopy at 2000L Scale in a GMP Environment Rutger Douma, Senior Manager Operations Bioprocessing Technology, Janssen Biologics, The Netherlands
15:00 Afternoon Coffee & Networking
DOWNSTREAM PROCESSING
15:30 Developing Downstream Processes for Intensified, Connected and Continuous Bo Qi, MSc., Senior Vice President, General Manager, Generon Biomed (Beijing)
16:30 Key Innovations in Downstream Processing to Overcome Challenges of Intensified ProcessingDanny Wu, Senior Biomanufacturing Engineering Manager, Merck, China
16:30 End of Pre-Conference Symposium
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MAIN CONFERENCE • THURSDAY, FEBRUARY 27, 2020
Room: Mizuho B (East) 7:15 Registration and Morning Coffee 7:55 Chairperson’s Opening Remarks
David W. Smith, Director, Healios K.K., Japan
STRATEGIES FOR GLOBAL COMMERCIAL SUCCESS – NOVEL TECH TRANSFER & MANUFACTURING MODELS ACROSS BORDERS
8:00 KEYNOTE PRESENTATION: Novartis/ Cellular Biomedicine Case Study – in China Robin Ng, Strategy Lead for Technology and Manufacturing, Cellular Biomedicine Group, China
8:30 KEYNOTE PRESENTATION: Experience with Yescarta in China Richard Wang, CEO, Fosun Kite, China
9:00 5 min changeover to BPI Asia Room: Mizuho B (North)
Room: Mizuho B (North)Chairperson: Habib Horry, Associate Director of Marketing - Upstream Process Integration - Next Generation BioProcessing, Merck Group, France
9:05 KEYNOTE PRESENTATION: Biopharmaceutical Manufacturing in China, Journey to Operational Excellence Kenneth Kang, Ph.D., Vice President, Commercial Manufacturing Operations, Innovent, China
OVERCOMING CHALLENGES WITH PROCESS INTENSIFICATION AND CONTINUOUS PROCESSING 9:35 Continuous Processing for Production of Monoclonal Antibodies
Scott Wheelwright, Ph.D., Principal Consultant, Complya Asia Co., Ltd., China
10:05 Networking Refreshment Break in the Exhibit & Poster Hall 11:00 Implementing Continuous Processing for Novel Modalities from Small to Large Scale – Lessons Learned from
Recent Progress Jun Hu, Director II, Virus Production, New Business Initiatives, Wuxi Biologics, China
11:30 Made-In-Japan Platform Technology For Therapeutic Antibody Manufacturing-Perspective For Project MABSei Murakami, Managing Director, Manufacturing Technology Association of Biologics
12:00 Lunch and Networking in the Exhibit & Poster Hall
DOWNSTREAM PROCESSING AND VIRAL SAFETY 13:30 Developing a Fully Automated, Flexible and Integrated Continuous Downstream Purification Platform and
Demonstration of the Production of Three Legacy Batch Processes Stuart Jamieson, Ph.D., Principal Scientist - Upstream, Downstream & Analytical, CPI Biologics, United Kingdom
14:00 Economics of Intensive/Continuous Downstream ManufacturingAndrew Sinclair, Managing Director, Biopharm Services, United Kingdom
14:30 Minimizing Resources in Developing Commercial Virus Filtration Processes with Planova™ BioEXTomoko Hongo-Hirasaki, Lead Expert of Evaluation and Analysis in Virus Filtration, Asahi Kasei Medical Co., Ltd., Japan
15:00 Networking Refreshment Break in the Exhibit & Poster Hall
ECONOMIC AND MANUFACTURING APPROACHES FOR CELL & GENE THERAPIES
15:30 Economic Implications of Automated Manufacture and Supply Chain for CAR T Cell Therapy Andrew Sinclair, Managing Director, Biopharm Services, United Kingdom
16:00 Commercial Manufacturing Requirements for Gene and Cell Therapies based on GMP Richard Denk, Senior Consultant, Aseptic Processing & Containment, SKAN AG, Switzerland
16:30 TELECONFERENCE: The Fate of Leachables: Development of Advanced Models to Predict Process Related LeachablesArmin Hauk, Principal Scientist, Sartorius-Stedim Biotech
17:05 Cocktail Reception in Exhibit & Poster Hall
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MAIN CONFERENCE • FRIDAY, FEBRUARY 28, 2020
Room: Mizuho B (North)
8:30 Registration and Morning Coffee
8:55 Chairperson’s Opening RemarksRichard Denk, Senior Consultant, Aseptic Processing & Containment, SKAN AG, Switzerland
NEXT GENERATION BIOPROCESSING STRATEGIES AND FACILITY DESIGN
9:00 KEYNOTE PRESENTATION: Developing and Applying Integrated Continuous Bioprocessing(ICB) Platform for Biologics Development and GMP Production in a Highly Flexible Modular Manufacturing FacilityChristopher Hwang, Ph.D., Chief Technology Officer, Transcenta Holdings, USA
9:30 KEYNOTE PRESENTATION: Next Generation Bioprocess Facility Design – a Case Study from Samsung BiologicsAnthony Newcombe, Senior Director, Samsung Biologics, South Korea
10:00 TELECONFERENCE: Process Analytical Technologies and Real- Time Monitoring Technologies for Product Quality Assessment and Process Monitoring Udayanath Aich, Associate Director, Bristol Myers Squibb, USA
10:30 Networking Refreshment Break in the Exhibit & Poster Hall
BIOMANUFACTURING STRATEGIES, TECHNOLOGY TRANSFER AND SCALE UP
11:00 TELECONFERENCE: Rethinking Innovation and Adopting Disruptive Technologies Denise Tan, Director, Process Development, Amgen Singapore Manufacturing, Singapore
11:30 Strategies To Accelerate Process Development and Reduce Manufacturing Cost For Biologics: A Case Study In Chugai PharmaceuticalHiroshi Murata, Ph.D. V.P., General Manager, Pharmaceutical Technology Division, Chugai Pharmaceutical Co. Ltd., Japan
This presentation will take place in the Cell Therapy Manufacturing Track, Room: Mizuho B (East)
12:00 DISCUSSION PANEL: Outsourcing vs. Insourcing – What is the best path to take? David W. Smith, Director, Healios K.K., Japan Jeonghoon Han Ph.D. (한정훈), Vice President, Chief Technology Officer, Head of R&D Center, EUTILEX, South Korea Robin Ng, Strategy Lead for Technology and Manufacturing, Cellular Biomedicine Group, China Kim Raineri, VP Operations, Nikon CeLL innovation, Japan
12:45 Lunch & Networking in the Exhibit & Poster Hall
Room: Mizuho B (North)
PROCESS ANALYTICAL TECHNOLOGIES AND REAL TIME MONITORING
14:00 Innovative Next-Generation Monitoring of Bioprocessing Enable Smart Data Management and AnalysisTakao Ito, Head of Manufacturing Sciences & Technology (MSAT) Japan and Korea, Merck Ltd. Life Sciences, Process Solutions, Japan
NOVEL MODALITIES
14:30 Development of HER2 Antibody Drug ConjugateScott M. Wheelwright, Ph.D., Senior Advisor, Bio-Thera Solutions Ltd., China
15:00 End of BPI Asia 2020
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MAIN CONFERENCE • THURSDAY, FEBRUARY 27, 2020
Room: Mizuho B (East) 7:15 Registration 7:55 Conference Opening and Welcome
David W. Smith, Director, Healios K.K., Japan
STRATEGIES FOR GLOBAL COMMERCIAL SUCCESS – NOVEL TECH TRANSFER & MANUFACTURING MODELS ACROSS BORDERS
8:00 Novartis/ Cellular Biomedicine Case Study – in ChinaRobin Ng, Strategy Lead for Technology and Manufacturing, Cellular Biomedicine Group, China
8:30 Experience with Yescarta in China Richard Wang, CEO, Fosun Kite, China
LATEST DATA & DEVELOPMENTS IN IPSC 9:00 Cell Engineering & Organ Replacement
Hardy TS Kagimoto, Chairman and CEO, Healios K.K., Japan
9:30 Consideration of standard specification and test methods for manufacturing of iPSC-MCB Takafusa Hikichi, Quality Control Unit Manager, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan
10:00 iPSCs-based Regenerative Medicine and Drug Development for CNS Diseases Hideyuki Okano, Team Leader, Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Dean, Keio University Graduate School of Medicine, Professor and Chairman, Department of Physiology, Keio University School of Medicine, Japan
10:30 Morning Coffee and Networking
TECHNOLOGIES AND NOVEL PLATFORMS FOR EFFICIENT UPSTREAM AND DOWNSTREAM PROCESSES
11:00 Manufacturing technologies for fulfilling the cell and gene therapy needs in AsiaColby Colasanto, Strategic Business Director, Cellogics, Singapore
11:30 CAR-NK Cell Line ManufacturingSae Won Kim, Head of Immune Cell Therapy Team, SL BIGEN, South Korea
12:00 Formation of uniform iPSC aggregates and scalable expansion in Vertical-Wheel BioreactorsBrian Lee, President, PBS Biotech Inc., USA
12:30 Lunch and Networking 1:40 Chairperson's Opening Remarks
Antonio Lee, Global Head, Business Development, MEDIPOST, Korea & CEO, MEDIPOST America, USA
1:45 Scaling Up MSc and EV Production into Bioreactors Maya Lim, Regional Account Manager, RoosterBio Inc., USA
2:15 Towards fast, accurate and affordable bioprocess control with chip technologyKatleen Verleysen, Strategic Partnerships Life Sciences, IMEC, Belgium
2:45 Refreshment Break in the Exhibition Hall
MANUFACTURING AUTOMATION: FROM VEIN TO VEIN
3:30 Preparing for commercialization – Evolution in Automation Approaches Damian Marshall, Director of New Technologies, Cell and Gene Therapy Catapult, UK
ENHANCED QUALITY & CLINICAL TRIAL RESULTS FOR CAR & T CELL PRODUCTS 4:00 The Evolving Product Landscape in China – Country Overview
Ting He, CEO, ImmunoChina Pharmaceuticals Co. Ltd., China
4:30 Introduction of Innovative T cell Therapies: 4-1BB Based Autologous T cell Therapy and MVR CAR-T Jeonghoon Han Ph.D. (한정훈), Vice President, Chief Technology Officer, Head of R&D Center, EUTILEX, South Korea
5:00 End of Day 2 + Evening Networking
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MAIN CONFERENCE • FRIDAY, FEBRUARY 28, 2020
8:15 Registration
8:40 Conference Opening and Welcome Maya Lim, Regional Account Manager, RoosterBio Inc., USA
TRANSITIONING TECHNOLOGIES FROM BENCH TO BEDSIDE: CRISPR, CAS9, GENE THERAPY AND MORE
8:45 Novel Non-Viral Vector Based CAR-T Platform Development and Progress Update Karen Wen, Chief Strategy and Product Development Officer, GenomeFrontier Therapeutics, Inc., Taiwan
9:15 ID Pharma Co., Ltd. Case Study – Sendai Virus Jitsutaro Kawaguchi, Manager, Department of Cell Engineering, ID Pharma Co., Ltd., Japan
9:45 Allogeneic Cord Blood-derived Cell Therapy Product CARTISTEM® for Osteoarthritis: Post-Market Status from Korea with Updates for Japan and the U.S.Antonio Lee, Global Head, Business Development, MEDIPOST, Korea & CEO, MEDIPOST America, USA
10:15 Morning Coffee and Networking
WORKING WITH EXTERNAL PARTNERS TO DRIVE COMMERCIALIZATION
11:00 Cell Therapy Manufacturing Commercialization - Strategy and Challenges Harry Lam, EVP, Head of Technical Operations, JW Therapeutics (Shanghai) Co., LTD., China
11:30 Overview of the Sumitomo Dainippon Manufacturing Plant for Regenerative Medicine & Cell Therapy – SMaRT Kenji Komeda, Senior Director, SMaRT, Regenerative & Cellular Medicine Manufacturing Plant, Sumitomo Dainippon Pharma Co., Ltd., Japan
12:00 DISCUSSION PANEL: Outsourcing vs. Insourcing – What is the best path to take? David W. Smith, Director, Healios K.K., Japan Jeonghoon Han Ph.D. (한정훈), Vice President, Chief Technology Officer, Head of R&D Center, EUTILEX, South Korea Robin Ng, Strategy Lead for Technology and Manufacturing, Cellular Biomedicine Group, China Kim Raineri, VP Operations, Nikon CeLL innovation, Japan
12:45 Lunch and Networking
UPSTREAM AND DOWNSTREAM SUPPLY CHAIN CONSIDERATIONS
1.55 Chairperson's Opening Remarks Kim Raineri, VP Operations, Nikon CeLL innovation, Japan
2:00 Perfecting a CAR T Supply Chain What is CAR T Therapy Naoki Kitadai, CAR T Supply Chain Lead, Celgene K.K., Japan
CELL CHARACTERIZATION – QUALITY CONTROL & ANALYTICAL STRATEGIES
2:30 Critical Quality Attributes & Controls for Cell Therapy Products Hidenori Nonaka, Group Leader, Regenerative Medicine Research & Planning Division, Rohto Pharmaceutical Co., Ltd., Japan
3:00 Chairperson’s Closing Remarks
3:15 End of Day 3
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THANK YOU TO OUR SPONSORS AND EXHIBITORS
GOLD SPONSOR
EXHIBITORS
Association Partner:
SILVER SPONSOR
SCIENTIFIC BRIEFING SPONSOR
EXHIBITORS
SILVER SPONSORS
CONFERENCE SUPPORTER
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EXHIBIT HALL FLOOR PLAN & EXHIBITOR LIST
BPI TrackRoom: Mizuhou North
Cell Therapy TrackRoom: Mizuhou East
POSTERS
17
Reg
istr
atio
n A
rea
3
13
14
15
16
11
9
5
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2
1
POSTERS
StandCompany Name Number
4Tune Engineering . . . . . . . . . . .6
Asahi Kasei Bioprocess. . . . . . .9
EMP Biotech . . . . . . . . . . . . . . . .1
Eurofins Biopharma . . . . . . . . . .5
Levitronix . . . . . . . . . . . . . . . . . .7
Nikon / Berkeley Lights . . . . . . .3
Repligen . . . . . . . . . . . . . . . . . . .8
Roosterbio . . . . . . . . . . . . . . . . .2
Sartorius Stedim Biotech . . . .11
StandCompany Name Number
CellGenix GmbH . . . . . . . . . . . .13
ChemoMetec . . . . . . . . . . . . . .14
The Japanese Society for Regenerative Medicine . . . . . .17
Lonza . . . . . . . . . . . . . . . . . . . . .16
PBS Biotech . . . . . . . . . . . . . . .15
THE NEXT GENERATION PROTEINS CONFERENCE LOOKING BEYOND ANTIBODIES TO TRANSFORM PROMISING PROTEINS INTO NEXT GENERATION MEDICINEhttps://informaconnect.com/next-gen-protein/
CAR AND T CELL THERAPIES: PIONEERING POINT OF CARE WITH INNOVATIVE MANUFACTURING AND COMMERCIALIZATION STRATEGIESinformaconnect.com/car-t/
Co-located EventsJune 22-24, 2020 • Hilton San Francisco Union Square, San Francisco, CA
Save 20% for all 3 events when you use discount code ‘CELLASIA’ Expires March 27, 2020
REAL LIFE NOVEL TECHNOLOGICAL ADVANCES FOR PRECISE EFFICIENT & SAFER GENOME EDITING – CHANGING THE FACE OF GENETIC DISORDERS AND RARE DISEASEinformaconnect.com/applications-of-gene-editing/
BRAND NEW EVENT
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4-DAY WEBCAST SERIES 22-25 June 2020 • 7-10 December 2020
BioProcess InternationalDigital Week
Cell & Gene Therapy Manufacturing April 20-23, 2020
Antibody Engineering & Therapeutics August 24-27, 2020
Clinical Trials May 11-14, 2020
Digital Week 2020 Event Calendar
MedTech October 19-22, 2020
New Ag International July 20-23, 2020
TIDES September 14-17, 2020
BioProcess International June 22-25, 2020 December 7-10, 2020
Join us for a comprehensive series of expert-led webcasts and useful resources to engage the bioprocessing community.
STAY UP TO DATE ON NEXT YEAR’S EVENTS
www.BioProcessAsia.com
www.informaconnect.com/celltherapy-asia