Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted

Imaging

Lakshman Gollapalli

Huntington’s Disease (HD)

• Huntington’s disease is a dominantly inherited degenerative disease of the CNS

• The pathological features include atrophy of the CN, chorea and neuronal loss

• Changes in caudate volume have been documented in MRI studies

Susceptibility Weighted Imaging (SWI)

• SWI exploits the magnetic susceptibility effects generated by local field inhomogeneities

• Signals from tissues with different susceptibilities compared to their neighboring tissue will become out of phase

• New type of contrast

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PHASE PLOT

Using SWI for noninvasive tracking of SVZ labeled cells in Rat subjected to stroke

• SVZ cells labeled with iron particles were injected in Rat subjected to stroke

• Using SWI as a means to track the cell migration and identify angiogenesis