Clinical Evidence

Clinical Studies

+ Bowman, S.J., 2014. The effect of vibration on the rate of leveling and alignment. Journal of clinical orthodontics, 48(11), pp. 678-688.+ Bowman, S.J., 2016. The Effect of Vibration on Molar Distalization. Journal of clinical orthodontics, L(11), pp. 683-693.+ Kau, C.H., 2011. A radiographic analysis of tooth morphology following the use of a novel cyclical force device in orthodontics. Head & Face Medicine, 7(14), pp. 1-5. + Kau, C.H., Nguyen, J.T., and English, J.D., 2010. The clinical evaluation of a novel cyclical force generating device in orthodontics. Orthodontic Practice US, 1(1), pp.10-15.+ Leethanakul, C., Suamphan, S., Jitpukdeebodintra, S., Thongudomporn, U., and Charoemratrote, C., 2016. Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement. The Angle Orthodontist, 86(1), pp. 74-80.+ Liao, Z., Elekdag-Turk, S., Turk, T., Grove, J., Dalci, O., Chen, J., Zheng, K., Darendeliler, M. A., Swain, M., Li, Q., 2017. Computational and clinical investigation on the role of mechanical vibration on orthodontic tooth movement. Journal of Biomechanics 60 (2017) 57-64.+ Lobre, W.D., Callegari, B.J., Gardner, G., Marsh, C.M., Bush, A.C., and Dunn, W.J., 2015. Pain control in orthodontics using a micropulse vibration device: A randomized clinical trial. The Angle Orthodontist, in press.+ Lombardo, L., Arreghini, A., Ghislanzoni, L. T. H., and Siciliani G., 2018. Accelerating aligner treatment using lowfrequency vibration: a single-centre, randomized controlled clinical trial. European Journal of Orthodontics, 2018, pp. 1-10.+ Orton-Gibbs, S., and Kim, N.Y., 2015. Clinical experience with the use of pulsatile forces to accelerate treatment. Journal of clinical orthodontics: JCO, 49(9), pp. 557-573.+ Pavlin, D., Anthony, R., Raj, V., and Gakunga, P.T., 2015. Cyclic loading (vibration) accelerates tooth movement in orthodontic patients: A double-blind, randomized controlled trial. Seminars in Orthodontics, 21(3), pp. 187-194.

Case Highlights

+ Castroflorio, T., 2017. Maxillary molar distalisation with aligners and cyclic forces. ortho international magazine of orthodontics, Vol. 2, Issue 2/2017, pp. 26-31.+ Kau C.H., 2009. A Novel Device in Orthodontics. Aesthetic Dentistry Today, 3(6), pp. 42-43.+ Ojima, K., Dan C., Nishiyama R., Ohtsuka S., Schupp W., 2014. Accelerated Extraction Treatment with Invisalign. Journal of clinical orthodontics: JCO, 48(8), pp. 487-499.+ Shapiro, E., Roeber, F.W., and Klempner, L.S, 1979. Orthodontic movement using pulsating force-induced piezo electricity. American Journal of Orthodontics, 76(1), pp. 59-66.+ Turatti, G., Salomone, A., Giordano, L., 2018. Non-extraction treatment of severe crowding with the aid of cyclic forces and corticotomy. ortho international magazine of orthodontics, Vol. 3, Issue 2/2018, pp. 12-16.+ Uribe, F., Agarwal, S., Shafer, D., and Nanda, R., 2015. Increasing orthodontic and orthognathic surgery treatment efficiency with a modified surgery-first approach. American Journal of Orthodontics and Dentofacial Orthopedics, 148(5), pp. 838-848.

In Vivo Studies

+ Al-Mubarak, R., Da Silveira, A., and Mao, J.J., 2005. Expression and mechanical modulation of matrix metalloproteinase-1 and-2 genes in facial and cranial sutures. Cell and tissue research, 321(3), pp. 465-471.+ Collins, J.M., Ramamoorthy, K., Da Silveira, A., Patston, P., and Mao, J.J., 2005. Expression of matrix metalloproteinase genes in the rat intramembranous bone during postnatal growth and upon mechanical stresses. Journal of Biomechanics, 38(3), pp. 485-492.+ Darendeliler, M.A., Zea, A., Shen, G., and Zoellner, H., 2007. Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study. Australian Dental Journal, 52(4), pp. 282-287.+ Kopher, R.A., and Mao, J.J., 2003. Suture growth modulated by the oscillatory component of micromechanical strain. Journal of Bone and Mineral Research, 18(3), pp. 521-528.+ Liu, D., 2010. Acceleration of Orthodontic Tooth Movement by Mechanical Vibration. Presented in AADR Annual Meeting. Washington, DC.+ Nishimura, M., Chiba, M., Ohashi, T., Sato, M., Shimizu, Y., Igarashi, K., and Mitani, H., 2008. Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics, 133(4), pp. 572-583.+ Peptan, A.I., Lopez, A., Kopher, R.A., and Mao, J.J., 2008. Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loading. Bone, 42(2), pp. 432-438.+ Shimizu Y., 1986. Movement of the lateral incisors in Macaca fuscata as loaded by a vibrating force. Nihon Kyosei Shika Gakkai Zasshi, 45(1), pp. 56-72.+ Vij, K., and Mao, J.J., 2006. Geometry and cell density of rat craniofacial sutures during early postnatal development and upon in vivo cyclic loading. Bone, 38(5), pp. 722-730.

In Vitro Studies

+ García-López, S., Villanueva, R., and Meikle, M.C., 2015. The effects of gentle micropulse vibration on two types of murine osteoblasts. Paper presented at the 2015 Annual Session May 15-19, AAO, San Francisco, CA.+ Lau, E., Al-Dujaili, S., Guenther, A., Liu, D., Wang, L., and You, L., 2010. Effect of low-magnitude, high-frequency vibration on osteocy tes in the regulation of osteoclasts. Bone, 46(6), pp. 1508-1515.+ Zhang, C., Li, J., Zhang, L., Zhou, Y., Hou, W., Quan, H., Li, X., Chen, Y., Yu, H., 2012. Effects of mechanical vibration on proliferation and osteogenic differentiation of human periodontal ligament stem cells. Arch. Oral Biol. 57, 1395–1407.

Kenji Ojima Article Reprint_JCO-March 2015_DinA4_01.indd 1 30.09.16 11:06

RCTCyclic loading (vibration) accelerates tooth movement in orthodontic patients: A double-blind,randomized controlled trial, 2015; Dubravko Pavlin et al.Assess the effect of AcceleDent on the rate of orthodontic tooth movement.

+ 45 patients treated with fixed appliances, mean age 21+ Retraction force of 180g applied with a coil spring between temporary anchorage device (TAD) and canine bracket + Analyzed: monthly rate of maxillary canine retraction into an extraction space+ Average rate of movement: mm/month: AcceleDent: 1,16; Control: 0,79; mean difference 0,37 (= 46,8%) (Confidence Interval [CI]: 95%; P-value: 0,05) analysis referred to intent-to-treat (ITT)

The results showed that low-level cyclic loading of 0.25N (25g) at 30Hz increases the rate of tooth movement when applied as an adjunct to orthodontic treatment.

RCTPain control in orthodontics using a micropulse vibration, 2015; Wendy Lobre et al. This peer-reviewed randomized controlled trial investigates the relationship between AcceleDent and pain / discomfort perception during orthodontic treatment.

+ 4-month test period, monthly adjustments and wire changes, fixed appliance patients only; 58 patients+ use of pain medication restricted during study+ evaluation of overall pain and biting pain which were both significantly reduced with the use of AcceleDent

RCTAccelerating aligner treatment using lowfrequency vibration: a single-centre, randomizedcontrolled clinical trial; 2018 Luca Lombardo et al.

+ Low-frequency vibrations have been proposed as a means of accelerating tooth movement and reducing orthodontic treatment times.+ Objective: To determine any differences in the accuracy of dental movement in patients treated with a low-frequency vibration aligner protocol and/or by reducing the aligner replacement interval with respect to a conventional protocol.

There was no difference in accuracy between replacing the aligners accompanied by low-frequency vibration every 7 days and replacing them every 14 days without vibration. Moreover, low-frequency vibration seemed to improve the accuracy of a conventional protocol in terms of upper incisor rotation.

Retrospective StudyThe Effect of Vibration on the Rate of Leveling and Alignment, 2014; S. Jay Bowman

+ retrospective evaluation of the effects of vibration on the time required for mandibular leveling and alignment with fixed appliances+ 117 consecutively treated Class II nonextraction patients; mean age: 13

Amount of time required to achieve both dental alignment and leveling in Class II nonextraction treatment was reduced. Overall 30% increase in the rate of tooth movement.

Case Report Accelerated Extraction Treatment with Invisalign, 2014; Dr. Kenji Ojima, Dr. Werner Schupp This report describes a patient (female, 26 yo) with severe anterior crowding who was treated with Invisalign appliances after the extraction of both upper canines and lower first premolars.

+ Class II molar relationship with a 3mm overjet and 1mm overbite+ Shorted the interval between aligner changes to five days+ Final results in 18 rather than at least 30 months

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November 2014

Jay Bowman Article Reprint_JCO-March 2015._DinA4_01indd.indd 1 29.09.16 10:01

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