european strategy forum on research infrastructures

InfrafrontierThe European infrastructure for phenotypingand archiving of model mammalian genomes

Coordinator: Prof. Martin Hrabé de AngelisProject Office: Dr. Michael Raess, Dr. Ana de CastroHelmholtz Zentrum München

www.infrafrontier.eu

European Strategy Forum on Research Infrastructures


ESFRI roadmap

• BBMRI – biobanking• EATRIS – translational research• ECRIN – clinical trials• ELIXIR – bioinformatics• Infrafrontier – animal disease models

• INSTRUCT – structural biology

• EU-OPENSCREEN – chemical biology• BLS4 – high security labs• Euro-BioImaging - bioimaging• EMBRC – marine biology

First roadmapin 2006



35projects

Update inDec2008Update inDec2008Update inDec2008

+ 10projects


Grand Challenges

- Understand genetic and environmental impact on human health

- Develop novel strategies for diagnosis, prevention and therapies


Current Biology

Why mouse?

• Mouse genome fully sequenced

• 95% similarity of the genes of mice and men

• Easy to breed and handle in captivity

• Extensive toolbox for manipulating the mouse genome


Why mouse?

Mouse models achieve high impact

Publications on ‘Mouse Models’


Shortage on capacities and access:

Phenotyping (characterising mouse models)• Mouse ClinicsEUMODIC, Infrafrontier

Archiving and Dissemination of mice and data • RepositoriesEMMA, Infrafrontier

The challenge


Required capacities

European Phenotyping Capacities

'00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13

Mouse Lines / year

0

250

500

750

1000

1250

1500

1750

•Archiving and distribution

•Phenotyping

EMMA Submissions (total)

'02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13

Mouse Lines

0

1000

2000

3000

4000

5000

6000

7000

1500 p.a.

420 p.a.

EMMA Requests (total)

'02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13

Mouse Lines

0

1000

2000

3000

4000

5000

6000

7000

1500 p.a.

350 p.a.


Access to phenotyping data and mouse models

Infrafrontier

Phenomefrontier Archivefrontier

+ emerging centres + emerging centres

Infrafrontier: two main parts

SystemicPhenotyping

Archivefrontier/EMMAArchiving /Distribution

Access to phenotyping services, data and mouse models


Capacity building required!


Osteogenesis imperfectaA group of genetic bone disorders ...

Noted People with OI• Jazz pianist Michel Petrucciani• Actor writer and ethicist Peter Radke...

In the mouse model:

Bisphosphonate treatment

… reverses bone phenotype

… but does not lower mortality


The German Mouse Clinic

www.mouseclinic.deNature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009


- Mutation in collagen I

Bone phenotype• Mineralisation defect• Bone deformity• fractures • Beaded ribs• Reduced Bone mineral content &

decreased bone mineral density

Systemic• Lung phenotype • Heart phenotype• Reduced fat mass & increased lean

mass• Metabolic alterations

Mouse model for Osteogenesis imperfecta


12 European Countries + Canada

Research Institutions + Funding Agencies

Infrafrontier partners


Infrafrontier partners


InfrastructureLarge Project

Smaller Project


Very large Project:

International Mouse Phenotyping Consortium (IMPC)


Infrafrontier and IMPCKeep in mind:•Infrafrontier is a BMS research infrastructure, NOT a single project•Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects)•State of the art research infrastructures are highly dynamic entities


Official start: 01 March 200836 months until: 28 February 2011

4.5 Mio € funding by the European Commission

Infrafrontier preparatory phase



Infrafrontier implementation


Access to mouse resources and data


Operation Costs

Cohort Breeding23,000 – 30,000 € per line

Phenotyping15,000 – 20,000 € per line

Mouse Archiving3,500 – 4,400 € per line

Mouse Distribution1,100 – 2,100 € per line

ES Cell Distribution? € per line

User Fees1,100 – 1,700 €

User Fees500 –700 €

User Feesto be developed


New mouse clinics and EMMA nodes

Established facilities

New facilities


Physical Infrastructure

Personnel

Operation

Technology Development

Integration of national & European funds

Nationalinfrastructure

funds

Nat

iona

l and

Euro

pean

Pro

ject

s

Funding Strategy


MS

MS

MS

MS

MS

EuropeanCommission

CentralCoordinationMS

MS = Member State

Decentralised funding model


Governance Infrafrontier ERIC (Boards)


Governance Infrafrontier ERIC (Tasks)


More Information ….

www.infrafro

ntier.eu


Resource Sharing Policy

The Rome Agenda:•“Funding organizations should … cover the costs of deposition of materials arising from projects as part of the project budget.”•“Funding agencies should … ensure appropriate data-sharing plans at the outset of projects …”


More Information ….

Coordinator:Prof. Dr. Martin Hrabé de [email protected]

Project Office:Dr. Michael RaessDr. Ana de [email protected]

Helmholtz Zentrum MünchenInstitute of Experimental GeneticsIngolstädter Landstrasse 185764 Neuherberg

InfrafrontierThe European infrastructure for phenotypingand archiving of model mammalian genomes

Coordinator: Prof. Martin Hrabé de AngelisProject Office: Dr. Michael Raess, Dr. Ana de CastroHelmholtz Zentrum München


Scope of Activities


Constructing Required Capacities

Mouse Clinics

Initial Investment (100 mouse lines):~ 15,000,000 € for Construction

~ 5,000,000 € for Equipment

Adding capacities for 100 lines~ 6,500,000 €

EMMA Repository

Initial Investment (100 mouse lines):~ 6,600,000 € for Construction~ 2,000,000 € for Equipment

Adding capacities for 100 lines~ 1,300,000 €


Maintaining Capacities

Mouse Clinics

Maintaining and Updating Equipment~ 20% of Purchasing Price per year

EMMA Repository

Cryo-Archive (100 mouse lines):~ 10,000 € per year

Maintaining and Updating Equipment~ 10% of Purchasing Price per year


Infrafrontier project – key objectives

• Preparation to meet increasing demands for phenotyping and archiving – capacity building• Developing a business plan based on a sustainable funding concept• Identification of the most suitable legal form• Providing a strategic plan for the construction phase• Reaching a legal agreement between all partners


ImplementationPreparatory Phase

Key deliverables

• WP2 – Strategy and Governance• WP3 – Legal Work• WP4 – Financial Work & Funding

2008 2009 2010 2011

WP2

WP3 Legal Work

MoU

Strategic PlanDraft Strategic Plan

WP4 Finance Business Plan

Legal status

Update

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