ethanol_4352156_4352135_english (gb)

7/31/2019 ETHANOL_4352156_4352135_English (GB)

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Conforms to Regulation (EC) No. 1907/2006 (REACH), Annex II - United Kingdom (UK)

SAFETY DATA SHEETETHANOL

SECTION 1: Identification of the substance/mixture and of thecompany/undertaking

1.1 Product identifier

Product name : ETHANOL

Product part number : 4352156

Kit name : ITRAQR REAGENTS MULTIPLEX KIT (Amine-Modifying Labeled Reagent forProtein and Peptide Quantitation)4352135

:Kit part number

Index number : 603-002-00-5

EC number : 200-578-6

CAS number : 64-17-5

Product description : Not available.

Product type : Liquid.

Other means ofidentification

: Not available.

Chemical formula : C2-H6-O

1.2 Relevant identified uses of the substance or mixture and uses advised against

Product use : For research use only. Not for use in diagnostic procedures.

1.3 Details of the supplier of the safety data sheet

AB SCIEX Pte. Ltd.110 Marsh DriveFoster City, CA USA 944041-877-740-2129

e-mail address of personresponsible for this SDS : [email protected]

1.4 Emergency telephone number

National advisory body/Poison Centre

Telephone number : Chemtrec : 1-800-424-9300 (24H)

Supplier

Telephone number : 1-877-740-2129 (8:30A PT - 5:00P PT)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Product definition : Mono-constituent substance

Classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]

Flam. Liq. 2, H225Eye Irrit. 2, H319STOT SE 3, H335 and H336

Classification according to Directive 67/548/EEC [DSD]

F; R11

See Section 16 for the full text of the R phrases or H statements declared above.

See Section 11 for more detailed information on health effects and symptoms.

2.2 Label elements

Date of issue/Date of revision : 10/30/2010. 1/13


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SECTION 2: Hazards identification:Hazard pictograms

Signal word : Danger

Hazard statements : Highly flammable liquid and vapour.

Causes serious eye irritation.May cause respiratory irritation.May cause drowsiness or dizziness.

Precautionary statements

Prevention : Wear protective gloves. Wear eye or face protection. Keep away from heat, sparks,open flames and hot surfaces. - No smoking. Use explosion-proof electrical,ventilating, lighting and all material-handling equipment. Use only non-sparkingtools. Take precautionary measures against static discharge. Keep container tightlyclosed. Use only outdoors or in a well-ventilated area. Avoid breathing vapour.Wash hands thoroughly after handling.

Response : IF INHALED: Remove victim to fresh air and keep at rest in a position comfortablefor breathing. Call a POISON CENTER or physician if you feel unwell.

IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skinwith water or shower.

IF IN EYES: Rinse cautiously with water for several minutes. Remove contactlenses, if present and easy to do. Continue rinsing.

If eye irritation persists: Get medical attention.

Storage : Store locked up. Store in a well-ventilated place. Keep cool.

Disposal : Dispose of contents and container in accordance with all local, regional, national andinternational regulations.

Supplemental labelelements

: Not applicable.

Special packaging requirements

Containers to be fittedwith child-resistantfastenings

: Not applicable.

Tactile warning of danger : Not applicable.

2.3 Other hazards

Substance meets thecriteria for PBT accordingto Regulation (EC) No.

1207/2006, Annex XIII

: No.

P: Not available. B: Not available. T: No.

Substance meets thecriteria for vPvB accordingto Regulation (EC) No.1207/2006, Annex XIII

: Not available.

Other hazards which donot result in classification

: Not available.



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SECTION 3: Composition/information on ingredients

Substance/mixture : Mono-constituent substance

Classification

Product/ingredientname

Identifiers % 67/548/EEC Regulation (EC) No.1272/2008 [CLP]

Type

ethanol EC: 200-578-6

CAS: 64-17-5Index: 603-002-00-5

100 F; R11 Flam. Liq. 2, H225

Eye Irrit. 2, H319STOT SE 3, H335 andH336

[A]

See section 16 forthe full text of the R-phrases declaredabove

See Section 16 for thefull text of the Hstatements declaredabove.

There are no additional ingredients present which, within the current knowledge of the supplier, are classified andcontribute to the classification of the substance and hence require reporting in this section.

Type

[A] Constituent[B] Impurity

[C] Stabilising additiveOccupational exposure limits, if available, are listed in Section 8.

SECTION 4: First aid measures

4.1 Description of first aid measures

Eye contact : Immediately flush eyes with plenty of water, occasionally lifting the upper and lowereyelids. Check for and remove any contact lenses. Continue to rinse for at least 10minutes. Get medical attention.

Inhalation : Remove victim to fresh air and keep at rest in a position comfortable for breathing. Ifit is suspected that fumes are still present, the rescuer should wear an appropriatemask or self-contained breathing apparatus. If not breathing, if breathing is irregularor if respiratory arrest occurs, provide artificial respiration or oxygen by trained

personnel. It may be dangerous to the person providing aid to give mouth-to-mouthresuscitation. Get medical attention. If necessary, call a poison center or physician.If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt orwaistband.

Skin contact : Flush contaminated skin with plenty of water. Remove contaminated clothing andshoes. Get medical attention if symptoms occur. Wash clothing before reuse.Clean shoes thoroughly before reuse.

Ingestion : Wash out mouth with water. Remove dentures if any. Remove victim to fresh airand keep at rest in a position comfortable for breathing. If material has beenswallowed and the exposed person is conscious, give small quantities of water todrink. Stop if the exposed person feels sick as vomiting may be dangerous. Do notinduce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medicalattention. If necessary, call a poison center or physician. Never give anything bymouth to an unconscious person. If unconscious, place in recovery position and getmedical attention immediately. Maintain an open airway. Loosen tight clothing suchas a collar, tie, belt or waistband.

Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. If it issuspected that fumes are still present, the rescuer should wear an appropriate maskor self-contained breathing apparatus. It may be dangerous to the person providingaid to give mouth-to-mouth resuscitation.

4.2 Most important symptoms and effects, both acute and delayed

Potential acute health effects



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SECTION 4: First aid measuresEye contact : Causes serious eye irritation.

Inhalation : Can cause central nervous system (CNS) depression. May cause drowsiness ordizziness. May cause respiratory irritation.

Skin contact : No known significant effects or critical hazards.

Ingestion : Can cause central nervous system (CNS) depression. Irritating to mouth, throat andstomach.

Over-exposure signs/symptoms

Eye contact : Adverse symptoms may include the following:pain or irritationwateringredness

Inhalation : Adverse symptoms may include the following:respiratory tract irritationcoughingnausea or vomitingheadachedrowsiness/fatiguedizziness/vertigounconsciousness

Skin contact : No specific data.

Ingestion : No specific data.

4.3 Indication of any immediate medical attention and special treatment needed

Notes to physician : Treat symptomatically. Contact poison treatment specialist immediately if largequantities have been ingested or inhaled.

Specific treatments : No specific treatment.

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishingmedia : Use dry chemical, CO2

, water spray (fog) or foam.

Unsuitable extinguishingmedia

: Do not use water jet.

5.2 Special hazards arising from the substance or mixture

Hazards from thesubstance or mixture

: Highly flammable liquid and vapour. In a fire or if heated, a pressure increase willoccur and the container may burst, with the risk of a subsequent explosion. Thevapour/gas is heavier than air and will spread along the ground. Vapours mayaccumulate in low or confined areas or travel a considerable distance to a source ofignition and flash back. Runoff to sewer may create fire or explosion hazard.

Hazardous combustionproducts

: Decomposition products may include the following materials:carbon dioxidecarbon monoxide

5.3 Advice for firefighters

Special precautions forfire-fighters

: Promptly isolate the scene by removing all persons from the vicinity of the incident ifthere is a fire. No action shall be taken involving any personal risk or without suitabletraining. Move containers from fire area if this can be done without risk. Use waterspray to keep fire-exposed containers cool.

Special protectiveequipment for fire-fighters

: Fire-fighters should wear appropriate protective equipment and self-containedbreathing apparatus (SCBA) with a full face-piece operated in positive pressuremode. Clothing for fire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection forchemical incidents.



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SECTION 5: Firefighting measures

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

For non-emergencypersonnel

: No action shall be taken involving any personal risk or without suitable training.Evacuate surrounding areas. Keep unnecessary and unprotected personnel fromentering. Do not touch or walk through spilt material. Shut off all ignition sources.No flares, smoking or flames in hazard area. Avoid breathing vapour or mist.

Provide adequate ventilation. Wear appropriate respirator when ventilation isinadequate. Put on appropriate personal protective equipment.

For emergency responders : If specialised clothing is required to deal with the spillage, take note of anyinformation in Section 8 on suitable and unsuitable materials. See also theinformation in "For non-emergency personnel".

6.2 Environmentalprecautions

: Avoid dispersal of spilt material and runoff and contact with soil, waterways, drainsand sewers. Inform the relevant authorities if the product has caused environmentalpollution (sewers, waterways, soil or air).

6.3 Methods and materials for containment and cleaning up

Small spill : Stop leak if without risk. Move containers from spill area. Dilute with water and mopup if water-soluble. Alternatively, or if water-insoluble, absorb with an inert drymaterial and place in an appropriate waste disposal container. Use spark-proof toolsand explosion-proof equipment. Dispose of via a licensed waste disposal contractor.

Large spill : Stop leak if without risk. Move containers from spill area. Approach the releasefrom upwind. Prevent entry into sewers, water courses, basements or confinedareas. Wash spillages into an effluent treatment plant or proceed as follows.Contain and collect spillage with non-combustible, absorbent material e.g. sand,earth, vermiculite or diatomaceous earth and place in container for disposalaccording to local regulations. Use spark-proof tools and explosion-proofequipment. Dispose of via a licensed waste disposal contractor. Contaminatedabsorbent material may pose the same hazard as the spilt product.

6.4 Reference to othersections

: See Section 1 for emergency contact information.See Section 8 for information on appropriate personal protective equipment.See Section 13 for additional waste treatment information.

SECTION 7: Handling and storage

The information in this section contains generic advice and guidance. The list of Identified Uses in Section 1 should beconsulted for any available use-specific information provided in the Exposure Scenario(s).

7.1 Precautions for safe handling

Protective measures : Put on appropriate personal protective equipment (see Section 8). Do not ingest.Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Use onlywith adequate ventilation. Wear appropriate respirator when ventilation isinadequate. Do not enter storage areas and confined spaces unless adequatelyventilated. Keep in the original container or an approved alternative made from acompatible material, kept tightly closed when not in use. Store and use away fromheat, sparks, open flame or any other ignition source. Use explosion-proof electrical(ventilating, lighting and material handling) equipment. Use only non-sparking tools.Take precautionary measures against electrostatic discharges. Empty containersretain product residue and can be hazardous. Do not reuse container.

Advice on generaloccupational hygiene

: Eating, drinking and smoking should be prohibited in areas where this material ishandled, stored and processed. Workers should wash hands and face beforeeating, drinking and smoking. Remove contaminated clothing and protectiveequipment before entering eating areas. See also Section 8 for additionalinformation on hygiene measures.



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SECTION 7: Handling and storage7.2 Conditions for safestorage, including anyincompatibilities

: Store in accordance with local regulations. Store in a segregated and approvedarea. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see section 10) and food anddrink. Store locked up. Eliminate all ignition sources. Separate from oxidizingmaterials. Keep container tightly closed and sealed until ready for use. Containersthat have been opened must be carefully resealed and kept upright to preventleakage. Do not store in unlabelled containers. Use appropriate containment toavoid environmental contamination.

7.3 Specific end use(s)

Recommendations : Not available.

Industrial sector specificsolutions

: Not available.

SECTION 8: Exposure controls/personal protection

The information in this section contains generic advice and guidance. The list of Identified Uses in Section 1 should beconsulted for any available use-specific information provided in the Exposure Scenario(s).

8.1 Control parameters

Occupational exposure limits

Product/ingredient name Exposure limit values

ethanol EH40/2005 WELs (United Kingdom (UK), 8/2007).TWA: 1000 ppm 8 hour(s).TWA: 1920 mg/m 8 hour(s).

Recommended monitoringprocedures

: If this product contains ingredients with exposure limits, personal, workplaceatmosphere or biological monitoring may be required to determine the effectivenessof the ventilation or other control measures and/or the necessity to use respiratoryprotective equipment. Reference should be made to European Standard EN 689 formethods for the assessment of exposure by inhalation to chemical agents andnational guidance documents for methods for the determination of hazardoussubstances.

Derived effect levels

No DELs available.

Predicted effect concentrations

No PECs available.

8.2 Exposure controls

Appropriate engineeringcontrols

: Use only with adequate ventilation. Use process enclosures, local exhaustventilation or other engineering controls to keep worker exposure to airbornecontaminants below any recommended or statutory limits. The engineering controlsalso need to keep gas, vapour or dust concentrations below any lower explosive

limits. Use explosion-proof ventilation equipment.

Individual protection measures

Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, beforeeating, smoking and using the lavatory and at the end of the working period.Appropriate techniques should be used to remove potentially contaminated clothing.Wash contaminated clothing before reusing. Ensure that eyewash stations andsafety showers are close to the workstation location.

Eye/face protection : Safety eyewear complying with an approved standard should be used when a riskassessment indicates this is necessary to avoid exposure to liquid splashes, mists,gases or dusts.

Skin protection



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SECTION 8: Exposure controls/personal protection

Hand protection : Chemical-resistant, impervious gloves complying with an approved standard shouldbe worn at all times when handling chemical products if a risk assessment indicatesthis is necessary.

Body protection : Personal protective equipment for the body should be selected based on the taskbeing performed and the risks involved and should be approved by a specialistbefore handling this product.

Other skin protection : Appropriate footwear and any additional skin protection measures should be

selected based on the task being performed and the risks involved and should beapproved by a specialist before handling this product.

Respiratory protection : Use a properly fitted, air-purifying or air-fed respirator complying with an approvedstandard if a risk assessment indicates this is necessary. Respirator selection mustbe based on known or anticipated exposure levels, the hazards of the product andthe safe working limits of the selected respirator.

Environmental exposurecontrols

: Emissions from ventilation or work process equipment should be checked to ensurethey comply with the requirements of environmental protection legislation. In somecases, fume scrubbers, filters or engineering modifications to the processequipment will be necessary to reduce emissions to acceptable levels.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical propertiesAppearance

Physical state : Liquid. [Clear.]

Colour : Colourless.

Odour : Alcohol-like.

49 ppmOdour threshold :

pH : Not available.

Melting point/freezing point : -113.9C

Initial boiling point and boilingrange

: 78.4C

Flash point : Closed cup: 12.85CEvaporation rate : 1.7 (butyl acetate = 1)

Flammability (solid, gas) : Not available.

Burning time : Not applicable.

Burning rate : Not applicable.

Upper/lower flammability orexplosive limits

: Lower: 3.3%Upper: 19%

Vapour pressure : 5.9 kPa [20C]

Vapour density : 1.6 [Air = 1]

Relative density : 0.79

Solubility(ies) : Not available.

Partition coefficient: n-octanol/water

: -0.32

Auto-ignition temperature : 398.85C

Decomposition temperature : Not available.

Viscosity : Not available.

Explosive properties : Not available.

Oxidising properties : Not available.

9.2 Other information

No additional information.



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SECTION 10: Stability and reactivity

10.1 Reactivity : No specific test data related to reactivity available for this product or its ingredients.

10.2 Chemical stability : The product is stable.

10.3 Possibility ofhazardous reactions

: Under normal conditions of storage and use, hazardous reactions will not occur.

10.4 Conditions to avoid : Avoid all possible sources of ignition (spark or flame). Do not pressurise, cut, weld,braze, solder, drill, grind or expose containers to heat or sources of ignition. Do notallow vapor to accumulate in low or confined areas.

10.5 Incompatible materials :

Reactive or incompatible with the following materials: oxidizing materials.peroxides acids alkalis Ammonia.

10.6 Hazardous

decomposition products

: Under normal conditions of storage and use, hazardous decomposition products

should not be produced.

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

Product/ingredient name Result Species Dose Exposure

ethanol LC50 Inhalation Vapour Rat 124700 mg/m3 4 hoursLD50 Oral Rat 7 g/kg -

Conclusion/Summary : Not available.

Irritation/Corrosion

Product/ingredient name Result Species Score Exposure Observation

ethanol Eyes - Mild irritant Rabbit - - -Eyes - Moderate irritant Rabbit - - -Eyes - Severe irritant Rabbit - - -Skin - Mild irritant Rabbit - - -


Sensitiser


Mutagenicity


CarcinogenicityConclusion/Summary : Not available.

Reproductive toxicity


Teratogenicity


Specific target organ toxicity (single exposure)

Product/ingredient name Category Route of exposure

Target organs

ethanol Category 3 Not determined Respiratory tractirritation and

Narcotic effects



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SECTION 11: Toxicological information

Specific target organ toxicity (repeated exposure)

Not available.

Aspiration hazard

Not available.

Information on the likely

routes of exposure

: Routes of entry anticipated:Oral, Inhalation.

Potential acute health effects

Inhalation : Can cause central nervous system (CNS) depression. May cause drowsiness ordizziness. May cause respiratory irritation.

Ingestion : Can cause central nervous system (CNS) depression. Irritating to mouth, throat andstomach.

Skin contact : No known significant effects or critical hazards.

Eye contact : Causes serious eye irritation.

Symptoms related to the physical, chemical and toxicological characteristics

Inhalation : Adverse symptoms may include the following:respiratory tract irritation

coughingnausea or vomitingheadachedrowsiness/fatiguedizziness/vertigounconsciousness

Ingestion : No specific data.

Skin contact : No specific data.

Eye contact : Adverse symptoms may include the following:pain or irritationwateringredness

Delayed and immediate effects and also chronic effects from short and long term exposureShort term exposure

Potential immediateeffects

: Not available.

Potential delayed effects : Not available.

Long term exposure

Potential immediateeffects

: Not available.

Potential delayed effects : Not available.

Potential chronic health effects

Not available.


General : No known significant effects or critical hazards.

Carcinogenicity : No known significant effects or critical hazards.

Mutagenicity : No known significant effects or critical hazards.

Teratogenicity : No known significant effects or critical hazards.

Developmental effects : No known significant effects or critical hazards.

Fertility effects : No known significant effects or critical hazards.

Other information : Not available.



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SECTION 12: Ecological information

12.1 Toxicity

Product/ingredient name Result Species Exposure

ethanol Acute EC50 2000 ug/L Fresh water Daphnia - Daphnia magna 48 hoursAcute LC50 25500 ug/L Marine water Crustaceans - Artemia

franchiscana - LARVAE48 hours

Acute LC50 42000 ug/L Fresh water Fish - Oncorhynchus mykiss 4 days

Chronic NOEC


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SECTION 13: Disposal considerations

Special precautions : This material and its container must be disposed of in a safe way. Care should betaken when handling emptied containers that have not been cleaned or rinsed out.Empty containers or liners may retain some product residues. Vapor from productresidues may create a highly flammable or explosive atmosphere inside thecontainer. Do not cut, weld or grind used containers unless they have been cleanedthoroughly internally. Avoid dispersal of spilt material and runoff and contact withsoil, waterways, drains and sewers.

SECTION 14: Transport information

ADR/RID ADN/ADNR IMDG IATA

14.1 UN number UN1170 1170 UN1170 UN1170

14.2 UN propershipping name

ETHANOL ETHANOL ETHANOL Ethanol

14.3 Transporthazard class(es)

3 3 3 3

14.4 Packinggroup

II II II II

14.5Environmentalhazards

No. Yes. No. No.

14.6 Specialprecautions foruser

Not available. Not available. Not available. Not available.

Additional

information

Hazard identification

number33

Limited quantityLQ4

CEFIC Tremcard30S1170

Special provisions144 601

Tunnel code

D/E

- Emergency

schedules (EmS)F-E, S-D

Passenger and

Cargo AircraftQuantity limitation: 5 LPackaginginstructions: 305Cargo Aircraft OnlyQuantity limitation:60 LPackaginginstructions: 307Limited Quantities -Passenger AircraftQuantity limitation: 1 LPackaging

instructions: Y305

14.7 Transport in bulkaccording to Annex II ofMARPOL 73/78 and the IBCCode

: Not available.



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SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

EU Regulation (EC) No. 1907/2006 (REACH)

Annex XIV - List of substances subject to authorisation

Substances of very high concern

None of the components are listed.

Annex XVII - Restrictions

on the manufacture,placing on the market anduse of certain dangeroussubstances, mixtures andarticles

: Not applicable.

Other EU regulations

Europe inventory : This material is listed or exempted.

Black List Chemicals : Not listed

Priority List Chemicals : Not listed

Integrated pollutionprevention and control

list (IPPC) - Air

: Not listed

Integrated pollutionprevention and controllist (IPPC) - Water

: Not listed

International regulations

Chemical WeaponsConvention List Schedule IChemicals

: Not listed

Chemical WeaponsConvention List Schedule IIChemicals

: Not listed

Chemical WeaponsConvention List Schedule IIIChemicals

: Not listed

15.2 Chemical SafetyAssessment

: Not available.

SECTION 16: Other information

Indicates information that has changed from previously issued version.

Abbreviations andacronyms

: ATE = Acute Toxicity EstimateCLP = Classification, Labelling and Packaging Regulation [Regulation (EC) No.1272/2008]DNEL = Derived No Effect LevelEUH statement = CLP-specific Hazard statementPNEC = Predicted No Effect ConcentrationRRN = REACH Registration Number

Procedure used to derive the classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]

Classification Justification

Flam. Liq. 2, H225 Expert judgmentEye Irrit. 2, H319 Expert judgment

STOT SE 3, H335 and H336 Expert judgment



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SECTION 16: Other information

Full text of abbreviated Hstatements

: H225 Highly flammable liquid and vapour.H319 Causes serious eye irritation.H335andH336

May cause respiratory irritation. May cause drowsiness or dizziness.

Full text of classifications[CLP/GHS]

: Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2Flam. Liq. 2, H225 FLAMMABLE LIQUIDS - Category 2

STOT SE 3, H335 andH336 SPECIFIC TARGET ORGAN TOXICITY (SINGLEEXPOSURE) [Respiratory tract irritation and Narcoticeffects] - Category 3

Full text of abbreviated Rphrases

: R11- Highly flammable.

Full text of classifications[DSD/DPD]

: F - Highly flammable

Date of printing : 10/30/2010.

Date of issue/ Date ofrevision

: 10/30/2010.

Date of previous issue : No previous validation

Version : 1

Notice to reader

To the best of our knowledge, the information contained herein is accurate. However, neither the above-namedsupplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of theinformation contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may presentunknown hazards and should be used with caution. Although certain hazards are described herein, we cannotguarantee that these are the only hazards that exist.


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