epilepsy medication audit at qech opc dr chipiliro kadzongwe mmed psych trainee, com, unima
TRANSCRIPT
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Epilepsy Medication Audit at QECH OPC
Dr Chipiliro kadzongweMMed Psych Trainee, CoM, UNIMA
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Outline
• Introduction • Methodology – Design – Sample size – Standards – Data collection
• Data analysis – Results
• Conclusions • Recommendations
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Introduction
• Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures
• The majority of the seizures can be controlled with appropriate medications with patients able to return to function
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Introduction
• Different causes – Genetic– past history of birth trauma– brain infections– head injury– in some cases, no specific cause can be identified
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Introduction
• Classification of epileptic seizures – Clinical type • Partial • Generalized
– Epilepsy syndromes
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Introduction
• Malawi epidemiology (Amos A & Wapling L, 2011)– Prevalence 2.8%– 55 % males – 45 % females
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Introduction
• Queen Elizabeth Central Hospital (QECH) tertiary hospital in Blantyre
• Care for patients with epilepsy shared between departments of internal medicine and psychiatry
• Initial assessment and diagnosis conducted by department of internal medicine – Neurologist available occasionally
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Introduction
• Follow up care is provided psychiatry nursing staff
• In 2012 the clinic had – an average of 51 patients per week– 240 patients per month– total of 2,875 visits
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Introduction
• Main challenges – Irregular availability of AEDs– Staff availability
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Introduction
• This was a baseline assessment for the existing prescribing practices
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Methods
• Prospective follow up audit on adult epilepsy patients; at least 100 patients
• Assessment of health passport books• Inclusion criteria – Patients with an established diagnosis of epilepsy
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Methods
• Exclusion criteria – Patients attending clinic for the first time– Children
• Data collected between March & April 2013
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Methods
• Compared available standards – Local• Malawi standard treatment guidelines (MSGT) 2008
– International • mhGAP Intervention Guide for mental, neurological and
substance use disorders in non-specialized health settings: 2010• Guidance on epilepsy in adults and children produced
by the National Institute for Health an Clinical Excellence (NICE); 2004
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Methods
• Standards– Record show seizure type has been classified – Records show that combination anti-epileptic drug
therapy, if prescribed , followed an adequate trial of monotherapy
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Methods
• Standards– The prescribed AEDs are within the recommended
maintenance dose ranges– Records show that all patients have had a review
in the previous 12 months– Record shows that seizure frequency has been
documented in the past 12 months
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Maintenance dose ranges for AEDs
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Data collection
• The following documentation was sought – a description of the seizures (ictal
phenomenology)– seizure type– reference to prescribed AEDs patient is taking,
where more than one drug was being taken, documentation of at least two periods of monotherapy that failed to gain adequate results
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Data collection
– reference to the dosage of AED patient taking– review of seizure frequency at least every 12
months
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Results
• Baseline Characteristics– 65 patient were included – 65 % (42) of the patients were males– 35 % (23) were females
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Results
• Baseline characteristics – Mean age of the patients is 30 years within the
range of 15 to 67 years– The mean age of seizure onset was 18 years within
the range of 6 months to 65 years
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Results
• Current Treatment– AEDs currently being used in then clinic are • Sodium valproate (VPA)• Carbamazepine (CBZ)• Phenobarbital (PHB)• Phenytoin (PHY)
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Results
• 69 % (45) of the clinic attendees were on monotherapy while 31 % (20) were on combination therapy
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Results
• Seizure type – 53 (82 %) did not have their seizure type
documented and classified – 12 (18%) had seizures classified
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Results
• Seizure frequency – All patients had their seizure frequency recorded
in the last 12 month – 65 % (42) of the patients had their seizures well
controlled
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Results
• Seizure frequency – 35% (23) had poor seizure control– 48% (11) of the patients with poor seizure control
had no change in their medication – With 2 (18%) patients only having a reason
indicated for not changing their medication
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Results
• Commonly prescribed AEDs
AEDs Number Percentage (%)
PHB 33 51
PHY 8 12
VPA 3 5
CBZ 1 2
PHB & CBZ 12 19
PHB & PHY 3 5
PHB & VPA 2 3
PHY & CBZ 1 2
VPA & CBZ 1 2
PHB/PHY/CBZ 1 2
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Results
• Starting therapy
Therapy Percentage (n)
No documentation 49 % (32)
Single drug 49% (32)
Combined 2 % (1)
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Results
• Minimum and maximum dose ranges for each AEDs
AEDs Minimum dose Maximum dose
PHB 60mg 210mg (3)
PHY 100mg (7) 400mg
VPA 200mg (1) 1600mg
CBZ 200mg (7) 1400mg
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Results
• In 28% (18) of the patients, the AEDs were not in maintenance treatment range
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Results
• Number of reviews in last 12 months – No clear indication of review patients’ seizures – 52% have 5 reviews in 12 months
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Results
• HIV Status
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Limitations
• Lack of documentation on when the patients started treatment
• Medication collected by family member on review
• Limited time for data collection
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Conclusion
• Lack of documentation on seizure type• Lack of justification for combination therapy• 28 % of AEDs doses not within the
maintenance treatment ranges • Lacks regular reviews• Good documentation of seizure frequency
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Recommendations
• Importance classification of epileptic seizures • Recording the justification for combination
therapy • Improved record keeping • At least 2 reviews of seizures and medications
in 12 months • Continue documentation on seizure frequency
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Recommendations
• Training of nursing staff • Institute standard prescribing guideline for the
epilepsy clinic • Re-audit
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Recommendations
• Other standards that could be audited – Side-effects – Drug interactions • HAART
– Safety of daily activities – Risks in pregnancy – Prognosis
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Acknowledgement
• Dr J. Ahrens, HoD, Department of Mental Health, CoM
• Ms M. Kumwenda, psychiatric nurse, QECH• Mr S. Maida
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References
• 1. Stokes T, Shaw EJ, Juarez-Garcia A, Camosso-Stefinovic J, Baker R. Clinical Guidelines and Evidence Review for the Epilepsies: diagnosis and management of the epilepsies in adults and children in primary and secondary care. London; 2004. Available at: http://www.nice.org.uk/nicemedia/live/10954/29533/29533.pdf.
• 2. Oakley C, Coccia F, Masson N, McKinnon I, Simmons M eds. 101 Receips for Audit in Psychiatry. London: RCPsych; 2011:47–48.
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References
• World Health Organisation Health. mhGAP Intervention Guide. Geneva; 2010. Available at: http://www.who.int/mental_health/mhgap.
• MoH. Malawi Standard Treatment Guidelines. Fourth. Lilongwe; 2008:25–27.
• Amos A, Wapling L. Epilepsy in Malawi. 2011.
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Education
never 10 15.38%primary 36 55.38%secondary 19 29.23%
Total 65 100.00%
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Age of onset by age group
Age group n %
<15 28 43
15-24 19 29
25-34 9 14
35-44 6 9
45-54 1 1.5
55-64 1 1.5
>64 1 1.5