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Epigenetics, Catalog

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Epigenetics

Antibodies

Quality Antibodies

Quality Results

www.genetex.com

The Company GeneTex produces high quality antibodies validated through extensive

research, development, and testing . Our staff and researchers have

collectively earned a trusted reputation from the research community for the

quality and reliability of our antibodies. The secret to our success is the

complementation of scientific expertise and production mastery in our

state-of-the-art laboratory and animal facility.

Our facility provides large-scale antibody production capabilities, which

employ highly specific antigen affinity purification. This has facilitated the

establishment of a comprehensive antibody collection covering a wide

spectrum of research fields .

Because of GeneTex's extensive experience in antibody manufacturing, we

are uniquely able to serve the demands of the scientific community by

providing accurate technical support and reliable customer service .

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Tel : 886.3.6208988 Tel : 1.949 .553 .1900

Table of Contents

DNA Modification .

Histone Code .... Histone Hi Antibody. Histone H2A Antibody . Histone H2B Antibody . Histone H3 Antibody . Histone H4 Antibody ..

.l!E

Histone Modifying Enzymes - Acetylation ... ...... ..... ...... . m Histone Modifying Enzymes - Methylation . .. ..... . ..... ... ... . m

Application Key

ChIP - Chromatin immunoprecipitation

Dot - Dot blot

ELISA - Enzyme- linked immunosorbent assay

I-ELISA - Indirect enzyme-linked immunosorbent assay using antigen

FACS - Fluorescence-activated cell sorting

ICC/IF - Immunocytochemistry / Immunofluorescence

IHC - Immunohistochemistry

IHC-Fr - ImmunohistochemistryFrozen sections

IHC-M - ImmunohistochemistryMethylmethacrylate sections

IHC-P - Immunohistochemistry-Paraffin-embedded sections

IP - Immunoprecipitation

MeDIP - Methylated DNA immunoprecipitation

WB - Western Blot

WB-Ag - Western Blot wi th antigen

Host & Reactivity Key

Amph - Amphibian Chicken - Chk Cow - Cow Dm - Drosophila Dog - Dog Gt - Goat Hm - Hamster Hu - Human Mamm- Mammal Mk - Monkey Ms - Mouse

Toil-free : 1.877.436.3839

Pig - Pig PInt - Plant Plant - Pint Rat - Rat Rb - Rabbit Sh - Sheep Vt - Vertebrate Zfsh - Zebra fish XI - Xenopus laevis Y - Yeast

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Ul

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C

rT (f)

DNA Modification

DNA Modification

DNA methylation involves the chemical modification of cytosine residues (5mc) through the addition of a

methyl group. This modification regulates gene expression without altering the DNA sequence, and is

carried out by two classes of function-opposing enzymes: DNA methyltransferases (DNMTs) and

methylcytosine dioxygenase (Ten Eleven Translocation; TETs). The methylated DNA is recognized by

methyl-CpG-binding domain proteins (MBDs) which recruit chromatin remodeling protein complex to form

compact, inactive chromatin, resulting in transcriptional repression. Accumulating studies have

demonstrated that dysfunctional controls of DNA methylation are associated with various diseases

including cancer.

5·mC & 5·hmC Antibody

5-mC

5-hmC

70.0

60.0

50.0

~ 40.0

~ 30.0

"" 20.0

10.0

0.0

Cat. No.

GTX629448

GTX629765

62.54

5-mC

• Conlrol lgG • 5-mC antibody

(GTX629448)

0.51 1.02

5-hmC

S.Methylcytosine antibody [GT4111]MeDiP grade (GTX629448) MeDIP analysis with 5-mC antibody on human genomic DNA mixed with 5-methylcytosine or 5-hydroxymethylcytosine DNA fragment.

DNA Methyltransferase (DNMT)

Cat. No.

Ci) GTXl16011

GTX48548 DNMT1

GTX88801

GTX14290

GTXl29125

DNMT3A GTXl29126

GTXl3887

GTX14291

Product

5-Methylcytosine antibcdy [GT4111]- MeDIP grade

5-Hydroxymethylcytosine antibcdy - MeDIP grade

S.Methylcytosine antibody [GT4111]MeDiP grade (GTX629448) IHC-P analysis with 5mC antibody on mouse testis tissue.

Product

DNMT1 antibcdy [N1J, N-terrn

DNMT1 antibcdy [60B1220.1]

DNMT1 antibcdy, Intemal

DNMT1 antibcdy

DNMT3A antibcdy

DNMT3A antibcdy

DNMT3A antibcdy [64B814]

DNMT3A antibcdy


Host & Clonality

MsrnAb

MsrnAb

50. 45. 40. 35.

:; 30. §- 25 ~ 20.

15. 10.

5. O.

Reactivity

Other

Other

5-hmC

• ControllgG . 5-hmCantibody

(GTX629765)

0.490.95

5-mC

S.Hydroxymethylcytosine antibodyMe DIP grade (GTX62976S) MeDIP analysis with 5-hmC antibody on human genomic DNA mixed with 5-hydroxymethylcytosine or 5-methylcytosine DNA fragment.

Host & Reactivity Clonality

RbpAb Hu

MsrnAb Hu, Ms, Zfsh

GtpAb Hu

ChkpAb Hu

RbpAb Hu

RbpAb Hu

MsrnAb HU,Ms

ChkpAb Hu, Ms, Rat

Ci)Citation

Application

MeDIP, Dol, IHC-P

MeDIP, IHC-P

S.Hydroxymethylcytosine antibodyMeDiP grade (GTX62976S) IHC-P analysis with 5hmC antibody on mouse prostate tissue.

Ci)Citation

Application

ICC/IF, IHC-P, IP, WB, ChiP assay

IHC-P, IP, WB, ChiP assay

ELISA, IHC-P, WB

WB

ICC/IF, IP, WB

IP,WB

IHC,WB

WB

DNA Methyltransferase (DNMT)

Cat. No.

GTX129127 DNMT3B

GTX50966

GTX115985 DNMT3L

GTX42020

120.0 104.89

100.0 c

80.0 Q)

E .c '-' 60.0 '§ Q)

'0 40.0 E 20.0

1.00 0.0

rabbit IgG DNMT1

DNMT1 antibody IN1), N·term (GTX116011) ChiP analysis with DNMTI antibody on chromatin extract of HCT116 cells.

Product

DNMT3B antibody

DNMT3B antibody [52A1018)

DNMT3L antibody [N1C1)

DNMT3L antibody [S 117-9)

DNMT3A antibody (GTX12912S) IHC-P analysis with DNMT3A antibody on mouse ovary tissue.

Methylcytosine Dioxygenase (TET)

Cat. No.

(9 GTX124207

TET1 GTX125888

(9 GTX627420

GTX629881

TET2 (9 GTX124204

GTX124205

GTX629881 (9 GTX121453

TET3 GTX628257

GTX628893

TET1 antibody [GT1462] (GTX627420) ICC!lF analysis with TET1 antibody on 293T cells.

Product

TET1 antibody [N3C1)

TET1 antibody [N1), N-tenm

TET1 antibody [GT1462)


TET2 antibody [N2), N-tenm

TET2 antibody [N2-2J, N-tenm


TET3 antibody [C3), C-tenm



kOa ~ ~'" v:-~v:-(l~

250-

130 -

95-

72-

TET1 antibody [N3C1] (GTX124207) WB analysis with TETI antibody on whole cell Iysates of HeLa cells (lane 1 ) or HepG2 cells (lane2).


Tel: 886.3 .6208988 Tel : 1.949.553.1900

Host & Clonality

RbpAb

MsmAb

RbpAb

MsmAb

MW (kOa)

250-

Reactivity

Hu

Hu, Ms

Hu

Hu

130- -

1078= ~-+ CtrllgG I

_1;.-DNMT3A

- - + - GTX1 291 25 IP + GTX1 291 26

DNMT3A antibody (GTX12912S) IP analysis with DNMT3A antibody on whole cell extracts of 293T cells.


RbpAb Hu, Ms

RbpAb Hu, Ms

MsmAb Hu

MsmAb Hu

RbpAb Hu

RbpAb Hu

MsmAb Hu

RbpAb Hu, Ms, XI, Bov

MsmAb Hu

MsmAb Hu

1 ( 18.

II

16. _ 14.

~ 12. -5 10 . . " 8. e: OJ

6. '0

:E 4 . 2. O.

TET2 antibody [GT649] (GTX629881) ChiP analysis with TET2 antibody on chromatin extract of HeLa cells.

Toll-free : 1.877.436.3839

DNA Modification

(9 Citation

Application

IP,WB


ICC/IF,WB

ICC/IF, IP, WB

MW (kOa)

250 -

130-

100 -70-

-DNMT3B

+ - Ct~lgG liP + GTX129127

DNMT3B antibody (GTX129127) IP analysis with DNMT3B antibody on nuclear extracts of K562 cells.

(9 Citation

Application

ICC/IF, IHC, IHC-P, WB, ChiP assay

ICC/IF,WB


IP, WB, ChiP assay

ICC/IF, IP, WB, ChiP assay


IP, WB, ChiP assay

ICC/IF, IHC-P, IP, WB, IHC-Wm

WB

WB

TET3 antibody [C3], C·term (GTX1214S3) IHC-P analysis with TET3 antibody on mouse colon tissue.

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III (f)

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C

rT (f)

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CJ o 0-

ro (f)

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;;tl ro (f)

c rT (f)

DNA Modification / Histone Code

Methyl·CpG·binding Domain Protein

MECP2

MBD1

MBD2

MBD3

MBD4

... kDa v:-~1J- ").$~ 130 -

95-72-

55-

43-

34-

26-

MECP2 antibody (GTX113230)

Cat. No.

GTX113230

GTX82405

GTX82658

GTX110612

GTX62737

GTX60359

GTX105622

GTX62868

GTX82965

GTX89182

GTX116204

GTX16309

GTX129605

WB analysis with MECP2 antibody on whole cell lysate of A431 cells or Jurkat cells.

Product

MECP2 antibody

MECP2 antibody

MeCP2 (phospho Ser80) antibody

MBD1 antibody [N2C2], Internal

MBD1 antibody [EPR3564]

MBD1 antibody - ChiP grade

MBD2 antibody [N2C3]

MBD2 antibody [EPR3519]

MBD2 antibody

MBD2 (isofonn 1) antibody, Intemal

MBD3 antibody [N1C3]

MBD3 antibody [106B691]

MBD4 antibody

MECP2 antibody (GTX113230) ICCIIF analysis with MECP2 antibody on A431 cells.

Histone Code


RbpAb HU,Ms

ChkpAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat

RbpAb Hu

RbmAb Hu

RbpAb Ms

RbpAb Hu

RbmAb Hu

RbpAb Hu, Ms, Rat

GtpAb Hu

RbpAb Hu

MsmAb Hu

RbpAb Hu

kDa )tJ.(,~'b\ 130-

95- -72-

55-

43-

34-

MBD1 antibody [N2C2], Internal (GTX110612) WB analysis with MBD1 antibody on whole cell lysate of Jurkat cells.

$ Citation

Application

ICC/IF,WB

WB

IHC,WB

WB

ICC/IF, IHC-P, IP, WB

ELISA, WB, ChiP assay

WB

ICC/IF, IHC-M, IHC-P, WB

WB

ELISA, IHC, IHC-P, WB

WB

IHC,WB

ICC/IF,WB

kDa " ~ . .j> l~' '<-~'" 130-

95-

72-

55- -43-

34-

26-

MBD2 antibody [N2C3] (GTX105622) WB analysis with MBD2 antibody on whole cell lysate of A431 cells, Jurkat cells, or Raji cells.

The nucleosome core particle is the fundamental structural unit of the eukaryotic genome. It consists of a

histone octamer composed of two H2A-H2B dimers and a H3-H4 tetramer wrapped by ",146 base pairs of

DNA. A linker histone (i.e., H1) associates with the nucleosomal dyad as well as with linker DNA on either

side of the nucleosome, resulting in the formation of the chromatosome. All the core and linker histones

are posttranslationally decorated, with at least 160 total modifications described to date including

acetylation, methylation, phosphorylation, propionylation, citrullination, formylation, proline isomerization,

butyrylation, ADP ribosylation, ubiquitylation, sumoylation, and the more recently identified glycosylation

and crotonylation. These modifications are thought to impact chromatin functions by either altering

chromatin packaging or through the recruitment/inhibition of specific chromatin binding factors. Thus, the

combined signal from a particular collection of histone marks constitutes a "histone code" that affects gene

expression or other chromatin-based functions.


~ Methylation Methyltransferases Demethylases

N' N terminus

C' C terminus

! ~ Phosphorylation Kinases

e Acetylation Histone Acetyltransferases

~ Ubiquitination Ubiquitin Ligases

IHzn l

N' RTK RKS K 23 4 8 9 10 14

Ml Ll-S 5UV39Hl",2 Ash! G9a

SMYDI GlP SMYD2 ESET SMYD3 CllS

SETDINIB RIZ SETD7/9 MLL1

LSD! SETDB! JARIDIA",D SETDB2

LSD! )HDM2A",B lMlD2A-D

Histone H1 Antibody

Cat. No.

GTXII4462

GTX117055

GTX122561

GTX104481

Unmodified GTX121670

GTX117438 (8 GTX117336

GTX87506 (8 GTX21938

GTX37669 Acetylation (8 GTX88006

N' 5

! , 300 300

• ';Kl - 21

RK K RKS 17 18

Icl ll

Product

Histone HI ,0 antibody

Histone H1.1 antibody

Histone Hl.2 antibody

Histone Hl.3 antibody

Histone Hl.4 antibody [Nl N2J, N-term

Testis-specific HI histone antibody

Histone Hit antibody [N1C3)

Histone HI antibody

Histone HI antibody

Histone HI antibody

Histone H1K25ac (acetyl Lys25) antibody

C'

TG

Phosphorylation (8 GTX121669 Histone HI S35ph (phospho Ser35) antibody

Histone Hl,O antibody (GTX114462) Histone Hl,2 antibody (GTX122561)

K

IHC-P analysis with Histone Hl,O antibody on C2C12 xenograft,

ICC/IF analysis with Histone H1,2 antibody on HeLa cells,


Tel: 886,3 .6208988 Tel : 1,949.553.1900

H !~9 •• ~ GK

! K K 36 20

79

1


RbpAb Hu, Ms, Rat

RbpAb Hu

RbpAb Hu

RbpAb HU,Ms

RbpAb Hu

RbpAb Hu

RbpAb Hu

RbpAb HU,Ms

ShppAb Ms, Mamm

RbpAb Hu, Ms, Rat

RbpAb Hu

RbpAb Hu

Histone Hl,3 antibody (GTX104481) IHC-P analysis with Histone H1,3 antibody on mouse stomach tissue.

Toll-free : 1,877.436.3839

Histone Code

J C'

KS K PASKAP N'

15 14 12

~~ 300 300

T K K K K R 5 N' 16 12

(8 Citation

Application

ICC/IF, IHC-P, WB

WB

ICC/IF, IHC-P, WB

ICC/IF,IHC-P

IHC-P,WB

WB

WB

ELISA, ICC/IF, IHC, IHC-P, WB

ICC/IF, IHC, IP, WB

ELlSA,WB


ICC/IF, IHC-P, WB

+ Nocodazole

I H1 .4S35ph

I H1

A B

Histone H1S35ph (phospho Ser35) antibody (GTX121669) WB analysis with Histone H1S35ph antibody on acid-extracted histones from HeLa cells treated withl without nocodazole,

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roT

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0-0 Cl.

III Vl

,0 C OJ

roT

-< ;;0 III Vl c roT

Vl

,0 c OJ

0-o 0.

III (f)

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;;tl III (f)

C

rT (f)

Histone Code

Histone H2A Antibody

Unmodified

Acetylation

Phosphorylation

Cat. No.

GTX129418 GTX81 004

GTX60347

GTX102073 (9 GTX108272

GTX108297

GTX127343 GTX62983

GTX108298

GTX60812 GTX63622

GTX60812

GTX128961 GTX61409

GTX60813

GTX127340 (9 GTX628789 (9 GTX61796

GTX127342 GTX48733

Histone H2A antibody (GTX129418) IHC-P analysis with Histone H2A antibody on mouse intestine tissue.

Histone H2B Antibody

Cat. No.

GTX115955

GTX129434

GTX87385 GTX61374

GTX21790 Unmodified GTX60346

GTX61423

GTX61455

GTX61979 GTX26689

GTX40618

GTX59545 GTX88015

Acetylation GTX128963

GTX61384 GTX88011

GTX61377

Product Host & Reactivity Clonality

Histone H2A antibody RbpAb Hu, Ms, Rat Histone H2A type 1 H antibody, N-term RbpAb Hu Histone H2A antibody -ChiP grade RbpAb Hu Histone H2AV antibody RbpAb Hu, Ms Histone H2AX antibody RbpAb Hu Histone H2AX antibody [N1 N2], N-term RbpAb Hu Histone H2AX antibody RbpAb Zfsh

Histone H2AX antibody [EPR895] RbmAb Hu, Ms, Rat Histone H2A.z antibody RbpAb Hu Histone H2A.Z antibody -ChiP grade RbpAb Hu Histone H2A.z antibody [EPR6172] RbmAb Hu, Ms, Rat Histone H2A.z antibody -ChiP grade RbpAb Hu Histone H2AK5ac (acetyl Lys5) antibody RbpAb Hu Histone H2AK5ac (acetyl Lys5) antibody [EP856Y], N-term RbmAb Hu, Ms, Rat Histone H2A.z (acetyl Lys5/Lys7/Lys11) antibody -ChiP grade RbpAb Hu, Ms Histone H2AXS 139ph (phospho Ser139) antibody RbpAb Hu, Ms Histone H2AXS139ph (phospho Ser139) antibody [GT2311] MsmAb Hu, Ms Histone H2AXS139ph (phospho Ser139) antibody [EP854(2)Y] RbmAb Hu, Ms, Rat Histone H2AXS 139ph (phospho Ser139) antibody RbpAb Zfsh Histone H2AVS137ph (phospho Ser137) antibody RbpAb Om

Histone H2A.X antibody (GTX108272) IHC-P analysis with Histone H2A.X antibody on mouse prostate tissue.

Histone H2AK5ac (acetyl Lys5) antibody (GTX128961)

Product

Histone H2B antibody


Histone H2B antibody Histone H2B antibody


Histone H2B antibody -ChiP grade Histone H2B antibody [EP819y]

Histone H2B antibody [EP957y]

Histone H2B Type 1B antibody [EP2327], N-term

Histone H2B antibody Histone H2B antibody

Histone H2B (acetyl) antibody Histone H2BK5ac (acetyl Lys5) antibody

Histone H2BK5ac (acetyl Lys5) antibody

Histone H2BK5ac (acetyl Lys5) antibody [EP857y] Histone H2BK12ac (acetyl Lys12) antibody

Histone H2BK12ac (acetyl Lys12) antibody [EP858y]

ICC/IF analysis with Histone H2AK5ac antibody on HeLa cells treated with O.4M Trichostatin A.


RbpAb Hu RbpAb Hu, Ms

RbpAb Hu, Ms

RbpAb Hu, Ms, Rat RbpAb Hu, Rat, At, Mamm

RbpAb Hu

RbmAb Hu, Ms RbmAb Hu, Ms, Rat

RbmAb Hu

RbpAb Mamm ShppAb Cow RbpAb Hu, Ms, Rat

RbpAb Hu, Ms RbpAb Hu RbmAb Hu, Ms, Rat

RbpAb Hu, Ms RbmAb Hu


(9 Citation

Application

IHC-P,WB

ELISA, FACS, IHC, IHC-P, WB Dot, ELISA, ChiP assay

ICC/IF,WB


IHC-P,WB IHC-Wm


ICC/IF, IHC-P, WB ELISA, ICC/IF, WB, ChiP assay, ChiP-seq

IHC, IHC-P, WB

ELISA. ICC/IF, WB, ChiP assay, ChiP-seq Dot, ICC/IF, IP, WB

ICC/IF, IHC-M, IHC-P, IP, WB Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq

ICC/IF,WB

ICC/IF, IP, WB

ICC/IF, IHC-M, IHC-P, WB IHC, IHC-P, IHC-Wm

ELlSA,WB

Histone H2A.X5139ph (phospho 5er139) antibody [GT2311] (GTX628789) ICC/IF analysis with Histone H2AXS139ph antibody on HeLa cells treated with cisplatin.

(9 Citation

Application

ICC/IF, IHC-P, WB

WB ELISA, ICC/IF, IHC, IHC-P, WB

ICC/IF, IHC-P, IP, WB ICC/IF, WB, ChiP assay

Dot, ELISA, ChiP assay

IHC-M, IHC-P, IP, WB

ICC/IF, IHC-M, IHC-P, IP, WB ICC/IF, IHC-P, WB

ELISA, ICC/IF, IP, WB

ELISA. WB IHC, IP,WB

ELISA, ICC/IF, IHC, IHC-P

Dot, ICC/IF, WB ICC/IF, IHC-M, IHC-P, IP, WB


ICC/IF, IHC-P, WB

Histone H2B Antibody

Acetylation

Cat. No. Product

GTX88002 Histone H2BK15ac (acetyl Lys15) antibody

GTX61756 Histone H2BK15ac (acetyl Lys15) antibody [EP955y]

GTX128962 Histone H2BK20ac (acetyl Lys20) antibody GTX61427 Histone H2BK20ac (acetyl Lys20) antibody [EP859y]

MW (kDa)

1~~ 40-35-25-

l Histooe H2B

15 - I .....-,-- - -~......__

10-


RbpAb HU,Ms

RbmAb Hu, Ms, Rat

RbpAb Hu

RbmAb Hu, Ms, Rat

Histone H2B antibody (GTX115955) Histone H2B antibody (GTX129434) Histone H2BK5ac (acetyl Lys5) antibody (GTX128963) IHC·P analysis with Histone H2B antibody on

H1299 xenograft.

Histone H3 Antibody

Cat. No.

CB GTX122148

GTX129546 GTX129552

GTX27834

GTX37670

CB GTX52367

GTX60349

GTX27031

Unmodified CB GTX10543

GTX122647

GTX127985 GTX50481

GTX110653

GTX80943 GTX101754

CB GTX112955

CB GTX115549 GTX60350

GTX60351

GTX60816

CB GTX121184

CB GTX50901

GTX60354

GTX60372

Methylation GTX630555

GTX60817

CB GTX50908 GTX60818

CB GTX50902

CB GTX121915 GTX60819

GTX61105

GTX128954

WB analysis with Histone H2B antibody on whole cell Iysates. ICC/IF analysis with Histone H2BK5ac antibody on

HeLa cells treated with D.4M Trichostatin A.

Product Host & Reactivity Clonality

Histone H3 antibody RbpAb Hu, Mk, Rice Histone H3 antibody RbpAb Ms, Ral Histone H3 antibody RbpAb Hu Histone H3 antibody Shp pAb Hu, Bov Histone H3 antibody RbpAb Hu, Ms, Rat Histone H3 antibody RbpAb Hu, Ms, Rat Histone H3 antibody - ChiP grade RbpAb Hu Histone H3 antibody [H3-P) MsmAb Hu Histone H3 antibody [HT A28] RatmAb Hu, Ms, Cow, Hm Histone H3.1 antibody RbpAb Hu Histone H3.1 antibody RbpAb Hu Histone H3.1 antibody RbpAb Hu, Ms, Rat Histone H3.1t antibody [N1C3) RbpAb 0 Histone H3.1t antibody, N-Ienn RbpAb Hu Histone H3.3 antibody RbpAb HU,Ms Histone H3.3 antibody RbpAb Hu, Ms, Rat, Rice Histone H3.3B antibody RbpAb Hu, Ms, Rat

Histone H3K27me1 (monomethyl Lys27) antibody -ChiP grade RbpAb Hu Histone H3K27me2 (dimethyl Lys27) antibody - ChiP grade RbpAb Hu Histone H3K27me3 (trimethy Lys27) antibody - ChiP grade RbpAb HU,Ms Histone H3K27me3 (trimethyl Lys27) antibody RbpAb Hu Histone H3K27me3 (trimethyl Lys27) antibody [MABI0323) MsmAb Hu Histone H3K36me1 (monomethyl Lys36) antibody· ChiP grade RbpAb Hu Histone H3K36me2 (dimethyl Lys36) antibody· ChiP grade RbpAb Hu Histone H3K36me2 (dimethyl Lys36) antibody [GT1488) MsmAb Hu Histone H3K36me3 (trimethy Lys36) antibody - ChiP grade RbpAb HU,Ms Histone H3K36me3 (trimethyl Lys36) antibody [MABI0333) MsmAb Hu Histone H3K4me1 (monomethyl Lys4) antibody -ChiP grade RbpAb HU,Ms Histone H3K4me1 (monomethyl Lys4) antibody [MABI0302) MsmAb Hu Histone H3K4me2 (dimethyl Lys4) antibody RbpAb Hu Histone H3K4me2 (dimethyl Lys4) antibody -ChiP grade RbpAb Hu Histone H3K4me2 (dimethyl Lys4) antibody [Y47) RbmAb Hu, Ms, Rat Histone H3K4me3 (trimethyl Lys4) antibody RbpAb Hu, Ms, Rat

GeneTex International Tel: 886.3.6208988 USA Tel: 1.949.553.1900 Toll-free: 1.877.436.3839

Histone Code

Application


ICC/IF, IHC-M, IHC-P, WB Dol, ICC/IF, IP, WB

CBCitation

FACS, ICC/IF, IHC-M, IHC-P, IP, WB

kDa

~g= 40-35-25-

10-

Histone H2BK20ac (acetyl Lys20) antibody (GTX128962) WB analysis with Histone H2BK2Dac antibody on whole cell lysate of HeLa cells treated with/ without D.4M Trichostatin A.

CBCitation

Application


IHC-P

WB IHC-P, IP, WB

ELISA, ICC/IF, IHC-P, WB IHC,WB

Dot, ELISA, WB, ChiP assay

Dot, FACS, I-ELISA, ICC/IF, WB

FACS, ICC/IF, WB

WB IHC-P,WB

ICC/IF,WB

WB-Ag ELlSA,WB

ICC/IF,WB IHC-P,WB

ICC/IF, IHC-P, WB

Dot, ELISA, ICC/IF, WB, ChiP assay Dot, ELISA, ICC/IF, WB, ChiP assay

Dot, ELISA, ICC/IF, WB, ChiP assay, ChlP·seq

ICC/IF, IHC·P, WB

ELISA, ICC/IF, WB, ChiP assay Dot, ELISA, ICC/IF, WB, ChiP assay

Dot, ELISA, ICC/IF, WB, ChiP assay, ChlP·seq

WB Dot, ELISA, ICC/IF, WB, ChiP assay, ChlP·seq

ELISA, ICC/IF, WB, ChiP assay

Dot, ELISA, ICC/IF, WB, ChiP assay, ChlP·seq ELISA, ICC/IF, WB, ChiP assay

ICC/IF, IHC·P, IP, WB, ChiP assay

Dot, ELISA, ICC/IF, WB, ChiP assay, ChlP·seq ICC/IF, IHC-P, WB

Dot, ICC/IF, IHC-P, WB

,0 c OJ

0-o Cl.

III Vl

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Histone Code

Histone H3 Antibody (9 Citation

Cat. No. Product Host & Reactivity Application Clonality

GTX60820 Histone H3K4me3 (trimethyl Lys4) antibody -ChiP grade RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq (9 GTX50897 Histone H3K4me3 (trimethyl Lys4) antibody [MABI0304) MsmAb Hu ELISA, ICC/IF, WB, ChiP assay

GTX60353 Histone H3K79me1 (monmethyl Lys79) antibody -ChiP grade RbpAb Hu Dot, ELISA, WB, ChiP assay GTX60821 Histone H3K79me1 (monomethyl Lys79) antibody -ChiP grade RbpAb Hu Dot, ELISA, WB, ChiP assay GTX60330 Histone H3K79me2 (dimethyl Lys79) antibody RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq GTX60336 Histone H3K79me3 (trimethyl Lys79) antibody - ChiP grade RbpAb HU,Ms Dot, ELISA, WB, ChiP assay GTX12177 Histone H3K9me1 (monomethyl Lys9) antibody RbpAb Hu, Ms, Cow, Rat, XI IHC-P,WB GTX129770 Histone H3K9me1 (monomethyl Lys9) antibody RbpAb Hu ICC/IF GTX60352 Histone H3K9me1 (monomethyl Lys9) antibody -ChiP grade RbpAb Hu Dot, ELISA, WB, ChiP assay GTX60356 Histone H3K9me1 (monomethyl Lys9) antibody -ChiP grade RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay

Methylation GTX60357 Histone H3K9me2 (dimethyl Lys9) antibody - ChiP grade RbpAb HU,Ms Dot, ELISA, ICC/IF, WB, ChiP assay (9 GTX50899 Histone H3K9me2 (dimethyl Lys9) antibody [MAB10307) MsmAb Hu ELISA, ICC/IF, WB, ChiP assay

GTX61106 Histone H3K9me2 (dimethyl Lys9) antibody [Y49) RbmAb Hu, Ms, Rat ICC/IF,WB ,0 (9 GTX121677 Histone H3K9me3 (trimethyl Lys9) antibody RbpAb Hu WB c OJ GTX60824 Histone H3K9me3 (trimethyl Lys9) antibody -ChiP grade RbpAb HU,Ms Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq

(9 GTX50900 Histone H3K9me3 (trimethyl Lys9) antibody [MABI0308) MsmAb Hu ELISA, ICC/IF, WB, ChiP assay rT GTX124113 Histone H3R17me2 (dimethyl Arg17) antibody RbpAb Hu Dot, IHC-P, WB -<

GTX60344 Histone H3R17me2 (dimethyl Arg17) antibody - ChiP grade RbpAb Hu Dot, ELISA, WB, ChiP assay ~ Histone H3R17me2K18ac (dimethyl Arg17, acetyl Lys18) antibody-:::l GTX60825 RbpAb HU,Ms Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq rT ChiP grade

0- GTX124114 Histone H3R2me2 (dimethyl Arg2) antibody RbpAb Hu Dot,WB 0 GTX60355 Histone H3K4ac (acetyl Lys4) antibody -ChiP grade RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay a.

GTX88008 Histone H3K14ac (acetyl Lys14) antibody RbpAb Hu, Ms, Rat ELlSA, ICCIlF III GTX61520 Histone H3K14ac (acetyl Lys14) antibody [EP964y) RbmAb HU,Rat ICC/IF, IHC-P, IP, WB (f)

GTX128943 Histone H3K18ac (acetyl Lys18) antibody RbpAb Hu, Ms, Rat Dot, ICC/IF, IHC-P, IP, WB, ChiP assay

,0 GTX60814 Histone H3K18ac (acetyl Lys18) antibody -ChiP grade RbpAb HU,Ms Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq c GTX61387 Histone H3K18ac (acetyl Lys18) antibody [EP959y) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB OJ GTX88017 Histone H3K23ac (acetyl Lys23) antibody RbpAb Hu, Ms, Rat ELISA, ICC/IF, WB

rT GTX128944 Histone H3K27ac (acetyl Lys27) antibody RbpAb Hu, Ms, Rat Dot, ICC/IF, IHC-P, IP, WB, ChiP assay -< GTX60815 Histone H3K27ac (acetyl Lys27) antibody -ChiP grade RbpAb HU,Ms Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq

;;tl (9 GTX50903 Histone H3K27ac (acetyl Lys27) antibody [MABI0309) MsmAb Hu ELISA, ICC/IF, WB, ChiP assay III Acetylation GTX61722 Histone H3K56ac (acetyl Lys56) antibody [EPR996y) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB (f)

(9 RbpAb c GTX12178 Histone H3K9ac (acetyl Lys9) antibody Hu, Ms, Cow, Rat, XI ICC/IF, IHC-P, WB

rT GTX88007 Histone H3K9ac (acetyl Lys9) antibody RbpAb Hu, Ms, Rat ELISA, ICC/IF, IHC, IHC-P, WB (f) GTX60823 Histone H3K9ac (acetyl Lys9) antibody -ChiP grade RbpAb Hu Dot, ELISA, WB, ChiP assay, ChiP-seq

(9 GTX12179 Histone H3K9ac (acetyl Lys9) antibody [AH3-120) MsmAb Hu, Ms, Om, Rat ELISA, ICCIIF, IHC, WB GTX630554 Histone H3K9ac (acetyl Lys9) antibody [GT464) MsmAb Hu ICC/IF,WB

(9 GTX50898 Histone H3K9ac (acetyl Lys9) antibody [MAB10305) MsmAb Hu ICC/IF, IP, WB, ChtP assay (9 GTX61103 Histone H3K9ac (acetyl Lys9) antibody [Y28) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, IP, WB

GTX122648 Histone H3K9K14ac (acetyl Lys9/Lys14) antibody RbpAb HU,Ms Dot, ICC/IF, WB GTX60822 Histone H3K9K14ac (acetyl Lys9/Lys14) antibody - ChiP grade RbpAb HU,Ms Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq GTX61388 Histone H3TK27ac (acetyl Lys27) antibody [EP865y) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB GTX61814 Histone H3.3S28phS31ph (phospho Ser28/Ser31) antibody [EP1874y) RbmAb Hu WB GTX62224 Histone H3.3S31ph (phospho Ser31) antibody [EPR1873) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB GTX12182 Histone H3S10ph (phospho Ser10) antibody RbpAb Hu, Ms, Cow, Rat, XI ICC/IF,WB GTX128116 Histone H3S10ph (phospho Ser10) antibody RbpAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChiP assay GTX60826 Histone H3S10ph (phospho Ser10) antibody -ChiP grade RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay GTX60827 Histone H3S10ph (phospho Ser10) antibody -ChiP grade RbpAb Hu Dot, ELISA, ICC/IF, IP, WB, ChiP assay GTX61 067 Histone H3S10ph (phospho Ser10) antibody [E173) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, IP, WB

Phosphorylation GTX630185 Histone H3S10ph (phospho Ser10) antibody [GT921) MsmAb Hu WB GTX128953 Histone H3S28ph (phospho Ser28) antibody RbpAb Hu Dot, ICC/IF, IHC-P, WB GTX79053 Histone H3S28ph (phospho Ser28) antibody RbpAb Hu, Ms, Rat ELISA, IHC, WB GTX13924 Histone H3S28ph (phospho Ser28) antibody [117C826) MsmAb Hu WB GTX61104 Histone H3S28ph (phospho Ser28) antibody [E191) RbmAb Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB GTX63813 Histone H3T11 ph (phospho Thr11) antibody [EPR5930) RbmAb HU,Rat WB GTX79055 Histone H3T3ph (phospho Thr3) antibody RbpAb Hu, Ms, Rat ELISA, IHC, WB GTX61749 Histone H3T3ph (phospho Thr3) antibody [EP1702y) RbmAb Hu ICC/IF, IHC-P, WB

GTX60329 Histone H3K27me3S28ph (trimethyl Lys27, phospho Ser28) antibody-

Phosphorylation ChiP grade RbpAb Hu Dot, ELISA, ICC/IF, IP, WB, ChiP assay

Methylation GTX60327

Histone H3K9me3S10ph (trimethyl Lys9, phospho Ser10) antibody-RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay

ChiP grade


Histone Code

Histone H3 Antibody (BCitation


GTX12181 Histone H3K9acSl0ph (phospho SerlO, acetyl Lys9) antibody RbpAb Hu, Ms, Cow, Rat, XI ICC/IF, IHC-P, WB Phosphorylation Acetylation GTX60328 Histone H3K9acSl0ph (phospho SerlO, acetyl Lys9) antibody RbpAb Hu Dot, ELISA, ICC/IF, WB, ChiP assay

GTX12180 Histone H3K9acSl0ph (phospho SerlO, acetyl Lys9) antibody IAPH3-64] MsmAb Hu, Ms, Om, Rat ELISA, IP, WB

• MyoD

49.59

Histone H3 antibody (GTX122148) ChiP analysis with Histone H3 antibody on chromatin extract of HeLa cells.

kDa ",0,.,"-

72 -~-55-43-34-

26-

Histone H3R17me2 (dimethyl Arg17) antibody (GTX124ll3) WB analysis with Histone H3R17me2 antibody on whole ceillysates.

II

Histone H3K27me3 (trimethyl Lys27) antibody (GTX12ll84) ICC/IF analysis with Histone H3K27me3 antibody on A431 cells.

70.

60.

~ 50

.§ 40. <.)

.~ 30.

~ 20 10.

• GAPDH _ f3-globin

promoter

63.35

1.001 .00 O.O-f---- ---.-

rabbit IgG H3K18ac

Histone H3K18ac (acetyl Lys18) antibody (GTX128943) ChiP analysis with Histone H3K18ac antibody on chromatin extract of HeLa cells.

Custom Antibody Services

Featured characteristics

180. 160.

_ 140.

~120 -5 100. § 80. ~ 60. :E 40.

20. 0 .. O-l~';;"';"";';';;";----.

mouse IgG H3K4me2

Histone H3K4me2 (dimethyl Lys4) antibody Histone H3K4me3 (trimethyl Lys4) antibody (GTX12l91S) (GTX1289S4) ChiP analysis with Histone H3K4me2 antibody on IHC-P analysis with Histone H3K4me3 antibody on chromatin extract of HeLa cells. mouse colon tissue.

Histone H3K27ac (acetyl Lys27) antibody (GTX128944) IHC-P analysis with Histone H3K27ac antibody on mouse duodenum tissue.

Histone H3Sl0ph (phospho SerlO) antibody (GTX128ll6) ICC/IF analysis with Histone H3S10ph antibody on HeLa cells.

Let GeneTex become your personal custom antibody production facility. GeneTex has produced over 25,000 polyclonal antibodies. Use our experience and expertise to help advance your reserch.

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Tel: 886.3 .6208988 Tel: 1.949.553.1900 Toll-free: 1.877.436.3839

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Histone Code

Histone H4 Antibody

Cat. No. Product Host & Reactivity Clonality

GTX10629 Histone H4 antibody RbpAb Hu, Ms, Rat

GTX52365 Histone H4 antibody RbpAb Hu, Ms, Rat Unmodified GTX129560 Histone H4 antibody RbpAb Ms, Rat

GTX129561 Histone H4 antibody RbpAb Ms, Rat GTX60345 Histone H4 antibody -ChiP grade RbpAb Hu

GTX128959 Histone H4K20me1 (monomethyl Lys20) antibody RbpAb Hu

GTX60331 Histone H4K20me1 (monomethyl Lys20) antibody [GT9008] MsmAb Hu GTX53591 Histone H4K20me2 (di-Methyl Lys20) antibody RbpAb Hu

GTX48878 Histone H4K20me2 (dimethyl Lys20) antibody [2B8] Rat Hu

Methylation GTX630545 Histone H4K20me2 (dimethyl Lys20) antibody [GT1851] MsmAb Hu GTX630544 Histone H4K20me2 (dimethyl Lys20) antibody [GT282] MsmAb Hu

GTX128960 Histone H4K20me3 (tMmethyl Lys20) antibody RbpAb Hu, Ms, Rat

GTX60828 Histone H4K20me3 (tMmethyl Lys20) antibody -ChiP grade RbpAb Hu, Ms

GTX60364 Histone H4K20me3 (tMmethyl Lys20) antibody [GT9009] MsmAb Hu

GTX88005 Histone H4K5ac (acetyl Lys5) antibody RbpAb Hu, Ms, Rat

GTX60335 Histone H4K5ac (acetyl Lys5) antibody -ChiP grade RbpAb Hu, Ms

GTX61421 Histone H4K5ac (acetyl Lys5) antibody [EP1000y], N-term RbmAb Hu, Ms, Rat



GTX60348 Histone H4K8ac (acetyl Lys8) antibody -ChiP grade RbpAb Hu

GTX60829 Histone H4K8ac (acetyl Lys8) antibody -ChiP grade RbpAb Hu

Acetylation GTX61411 Histone H4K8ac (acetyl Lys8) antibody [EP1002y], N-term RbmAb Hu, Ms, Rat GTX88003 Histone H4K12ac (acetyl Lys12) antibody RbpAb Hu, Ms, Rat


GTX63069 Histone H4K16ac (acetyl Lys16) antibody [EPR1004] RbmAb Hu, Ms, Rat

GTX60337 Histone H4K5K8K12ac (acetyl Lys5/Lys8/Lys12) antibody - ChiP grade RbpAb Hu, Ms

GTX122653 Histone H4K5K8K12K16ac (acetyl Lys5/Lys8/Lys121Lys16) antibody RbpAb Hu, Ms, Rat

GTX60334 Histone H4K5K8K12K16ac (acetyl Lys5/Lys8/Lys121Lys16) antibody-

RbpAb Hu, Ms ChiP grade

16. 500.

14. 450.

e 12. 400.

~350. ~ 10 E300. .c

8. :§ 250 . " ." ~200. c 6. <V

'0 :Q 150. E 4. .E 100.

2. 50. O. O.

Histone H4 antibody (GTX129560) ICC/IF analysis with Histone H4 antibody on HeLa cells.

Histone H4K20me2 (dimethyl Lys20) antibody [GT1S51] (GTX630545)

Histone H4KSac (acetyl LysS) antibody (GTX12S957)

ChiP analysis with Histone H4K20me2 antibody on chromatin extract of HeLa cells.

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A

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ChiP analysis with Histone H4KBac antibody on chromatin extract of HeLa cells.

8 Citation

Application

IHC-P, IP, WB

ICC/IF, IHC, WB

ICC/IF,IHC-P

IHC-P

Dot, ELISA, ChiP assay

Dot, ICC/IF, WB

Dot, ICC/IF, WB, ChiP assay, ChiP-seq

Dot, FACS, IHC, WB

IP,WB

ICC/IF, WB, ChiP assay



Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq



Dot, ELISA, WB, ChiP assay, ChiP-seq

ICC/IF, IHC-M, IHC-P, IP, WB

Dot, ICC/IF, IHC-P, IP, WB, ChiP assay

IHC, IP,WB

Dot, ELISA, WB, ChiP assay

Dot, ELISA, ICC/IF, WB, ChiP assay

ICC/IF, IHC-M, IHC-P, IP, WB


ELISA, ICC/IF, IHC, IHC-P


Dot, ELISA, ICC/IF, WB, ChiP assay, ChiP-seq


Dot, ELISA, ICC/IF, ChiP assay, ChiP-seq

kDa

72-A

55-43-

34-

26-

17- -10-

Histone H4K5KSK12K16ac (acetyl Lys5/ LysS/Lys12/Lys16) antibody (GTX122653) WB analysis with Histone H4K5KBK12K16ac antibody on whole cell lysate of HeLa cells.

Histone Modifying Enzymes - Acetylation


Acetylation is one of the most intensively studied posttranslational modifications (PTMs) of histone and

non-histone substrates. For histones, members of the three major subfamilies of histone acetyltransferases

(HATs; but also referred to as lysine acetyltransferases (KATs)) target lysine residues for transfer of an

acetyl group obtained from acetyl-CoA. Histone acetylation is generally associated with gene activation,

while histone deacetylation catalyzed by histone deacetylases (HDACs/KDACs) is linked to gene repression.

The dynamic interplay between the activities of the HATs and HDACs, in conjunction with the histone marks

inserted by other histone modifying enzymes, determines the key features of the local chromatin landscape

that regulates a specific gene's expression. HDAC inhibitors have generated much interest clinically,

particularly in cancer therapeutics. However, there is also growing awareness of "histone code" signatures

that control gene expression in post-mitotic neurons, thereby affecting neural plasticity and complex

higher-order brain functions such as learning and memory. Given that some HATs are directly involved in

these processes, and that loss of HA T activity has been described in neurodegenerative disease, the

development of specific HAT/HDAC modulators is an exciting area for future research.

Histone Acetyltransferase (HAT) (BCitation


GTX101249 CBP antibody [C3]. C-term RbpAb Hu, Ms, Mk ICC/IF, IHC, IHC-P, IP, WB, ChiP assay

CBP GTX30750 CBP antibody [F4] MsrnAb Hu, Ms, Rat ICC/IF, IHC, IP, WB GTX86958 CBP (acetyl Lys1535) antibody RbpAb Hu, Ms, Rat ELISA, IHC, IHC-P GTX102318 CLOCK antibody [C2C3], C-term RbpAb HU,Ms ICC/IF, WB

CLOCK GTX63487 CLOCK antibody [EPR6227] Rb rnAb Hu, Ms, Rat FACS, ICC/IF, IHC, IHC-P, IP, WB GTX83280 CLOCK antibody [8F?] MsrnAb Hu ELISA, FACS, ICC/IF, WB GTX111912 ELP3 antibody [N3C3] RbpAb Hu ICC/IF, WB

ELP3 GTX111492 ELP3 antibody [N1C1] RbpAb Hu WB GTX631395 ELP3 antibody [GT11811] MsrnAb Hu WB GTX114428 GCN5 antibody [C2C3], C-term RbpAb Hu,Ms ICC/IF, WB

GCNS GTX100286 GCN5 antibody [C3], C-term RbpAb Hu WB GTX50005 GCN5L2 antibody [AT3G13] MsrnAb Hu ELISA, ICC/IF, WB GTX118874 GTF3C4 antibody RbpAb Hu ICC/IF, IHC-P, WB

GTF3C4 GTX88274 GTF3C4 antibody, Internal GtpAb Hu, Ms, Cow, Dog, Rat ELISA GTX110643 HAT1 antibody RbpAb Hu ICC/IF, IHC-P, IP, WB

HAT1 GTX12163 HAT1 antibody RbpAb Hu,Ms WB GTX129380 MYST1 antibody RbpAb Hu WB GTX82545 HMOF I MYST1 antibody, C-term RbpAb Hu ELISA, IHC, IHC-P, WB

MYST GTX83065 MYST1 antibody [8C4C4] MsrnAb Hu ELISA, ICC/IF, IHC, IHC-P, WB GTX102041 MYST2 antibody [N2C1], Internal RbpAb HU,Ms IHC-P, WB GTX63686 MYST2 antibody [EPR7194(B)] Rb rnAb Hu, Ms, Rat FACS,WB GTX112197 TIP60 antibody RbpAb HU,Ms ICC/IF,WB

TIP60 GTX112198 TIP60 antibody RbpAb Hu IHC-P, WB GTX83081 TIP60 antibody [3F9] MsrnAb Hu ELISA, IHC, IHC-P, WB GTX10485 EP300 antibody RbpAb Hu IHC,IP,WB

p300 GTX10486 EP300 antibody RbpAb Hu IHC,IP,WB

GeneTex International Tel: 886.3 .6208988 USA Tel: 1.949.553.1900 Toll-free: 1.877.436.3839

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Histone Acetyltransferase (HAT)

Cat. No.

p300 GTX30618

GTX30614 (!) GTX109666

PCAF GTX12188 GTX112567

NCOA1 (!) GTX70250

GTX23247 GTX112307

NCOA2 GTX10508

GTX10491 GTX19198

GTX113869

NCOA3 GTX104257

GTX83144

7.0 ,..-",sn",a::.il", Plr.::;om",o::.:t;;::er---,

6.0

5_0

:2 4_0 0

u.. 3.0

2.0

1_0

0_0

-

D A B

CBP antibody [C3] . C-term (GTX101249) ChiP analysis with CBP antibody on whole cell extract of HeLa cells.

MW (kOa)

55-

40-

- ....... I--MYST1

..

MYST1 antibody (GTX129380) WB analysis with MYSTl antibody on whole cell Iysates or 293T nuclear extract.

Histone Deacetylase (HDAC)

Cat. No.

(!) GTX100513

GTX20012

HDAC1 GTX62894 GTX27028

GTX124499

GTX109642 GTX113086

HDAC2 GTX112957 (!) GTX12169

GTX61236

(!) Citation

Host & Reactivity Application Clonality Product

EP300 antibody [RW105] MsmAb Hu, Ms, Mk, Rat, Mink ICC/IF, IP, WB, ChiP assay EP300 antibody [RW128] MsmAb Hu, Ms, Mk, Rat, Mink ICC/IF, IP, WB PCAF antibody [C3], C-tenm RbpAb Hu, Ms

PCAF antibody RbpAb Hu, Ms, Dog SRC1 antibody RbpAb Hu SRC1 antibody [1135] MsmAb Hu, Ms, Mk, Rat SRC1 antibody [SRC01 (GT12)] MsmAb Hu, Ms NCOA2 antibody [C2C3], C-tenm RbpAb Hu NCOA2 antibody RbpAb Hu, Ms, XI

NCOA2 antibody RbpAb Hu, Ms, XI NCOA2 antibody RbpAb Hu NCOA3 antibody [N1 N2], N-tenm RbpAb Hu

NCOA3 antibody RbpAb Hu NCOA3 antibody [2C11 B12] MsmAb Hu

.-. ::-:., .... -.. _ ...... . ~ . .:~ .. . ,' ... ~ '~' . .,

" .. ,~ .... ~ .... t

72-

55-

43-

GCNS antibody [C2C3]. C-term (GTX114428) GTF3C4 antibody (GTX118874) WB analysis with GCN5 antibody on whole cell IHC-P analysis with GTF3C4 antibody on human lysate of IMR32 cells. breast carcinoma.

TIP60 antibody (GTX112198) IHC-P analysis with TIP60 antibody on HeLa xenograft.

Product

HDAC1 antibody

HDAC1 antibody

HDAC1 antibody [EPR460(2)], C-tenm

HDAC1 antibody Hdac1 antibody

HDAC2 antibody

HDAC2 antibody HDAC2 antibody

HDAC2 antibody [HDAC2-62] HDAC2 antibody [y461], C-tenm

250-

130 -

95-72-

A

SRC1 antibody (GTX112S67) WB analysis with SRCl antibody on whole cell lysate of 293T cells.


RbpAb HU,Ms

RbpAb HU,Ms

RbmAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat RbpAb Zfsh

RbpAb Hu, Ms, Rat

RbpAb Hu RbpAb Rat

MsmAb Hu, Ms, Cow, Dog, Rat

RbmAb Hu, Ms, Rat

WB IP,WB

WB

IP, WB, ChiP assay ICC/IF, IHC-P, WB

ICC/IF,WB IHC,IP,WB

IP,WB

IP

ICC/IF, IHC-P, WB ICC/IF

ELlSA,WB

HAT1 antibody (GTX110643) IHC-P analysis with HATl antibody on colon tissue.

NCOA2 antibody [C2C3]. C-term (GTX112307) ICCIIF analysis with NCOA2 antibody on HeLa cells.

(!) Citation

Application


ELISA, ICC/IF, IP, ChiP assay

ICC/IF, IHC-M, IHC-P, WB Dot, IHC-P, IP, WB, ChiP assay

IHC-P, WB, IHC-Wm


ICC/IF, IHC-P, WB

WB ELISA, ICC/IF, IHC, IP, WB

FACS, ICC/IF, IHC-M, IHC-P, IP, WB


Histone Deacetylase (HDAC)

Cat. No.

HDAC2 GTX50236

8 GTX109679

8 GTX113303 HDAC3 8 GTX103699

GTX124349

GTX110231

8 GTX12171

HDAC4 GTX50237

GTX85618

GTX61209

GTX21439

HDAC5 GTX59634

GTX50238

HDAC6 8 GTX100722

8 GTX84377

HDAC7 GTX114179

GTX105985

GTX113981

HDAC8 GTX105074

GTX12176

GTX50189

HDAC9 GTX52378

GTX63403

GTX62462

HDAC10 GTX84385

GTX84388

GTX84387

HDAC11 GTX118403

GTX18973

HDAC1 antibody (GTX100513) IHC-P analysis with HDAC1 antibody on mouse colon tissue.

HDAC6 antibody [N1], N-term (GTX100722) ICCIIF analysis with HDAC6 antibody on HeLa cells.

Product

HDAC2 (phospho Ser394) antibody

HDAC3 antibody [C3], C-term

HDAC3 antibody

HDAC3 antibody [N2C3]

Hdac3 antibody

HDAC4 antibody [N3C1], Intemal

HDAC4 antibody [HDAC-144]

HDAC4 (phospho SerB32) antibody

HDAC4 (phospho SerB32) antibody

HDAC4 antibody [y416], N-term

HDAC5 antibody

HDAC5 antibody


HDAC6 antibody [N1], N-term

HDAC6 antibody [4C5]

HDAC7 antibody [C2C3], C-term

HDAC7 antibody

HDAC8 antibody

HDAC8 antibody [N1 C2]

HDAC8 antibody [HDACB-48]


HDAC9 antibody

HDAC9 antibody [EPR5223]

HDAC10 antibody [EPR3576]

HDAC10 antibody [8G5]

HDAC10 antibody [3C2]

HDAC10 antibody [2H6]

HDAC11 antibody

HDAC11 antibody

4.0

3.5

3.0

2.5

GAPDH promoter

-

'0

~ 2.0

1.5

0.5 1.0 D 0.0 ........ -:A ....... ~~B~....I

HDAC2 antibody (GTX109642) ChiP analysis with HDAC2 antibody on whole cell extract of 293T cells.

kDa ","-",'"

170-

130- .. -

95-

72-

55-

43-

HDAC7 antibody (GTX105985) WB analysis with HDAC7 antibody on whole cell lysate of 293T cells.


Tel: 886.3 .6208988 Tel: 1.949.553.1900



RbpAb Hu, Ms, Rat

RbpAb Hu

RbpAb Hu, Rat

RbpAb Hu

RbpAb Zfsh

RbpAb Hu

MsmAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat

RbmAb Hu

RbpAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat

RbpAb Hu

MsmAb Hu, Dog, Mk, Rat

RbpAb Hu

RbpAb Hu

RbpAb Hu, Ms, Rat

RbpAb Hu, Ms

MsmAb Hu

RbpAb Hu, Ms, Rat

RbpAb Hu

RbmAb Hu, Rat

RbmAb Hu, Ms

MsmAb Hu

MsmAb Hu

MsmAb Hu

RbpAb Hu, Ms

RbpAb Hu, Ms, Rat

!ill2 " ~ "", <{?,f'" "-~ .

170-,);0)'" ~"j v:-"~ ~ ~ ~~ ~~~

130-

95-

72-

55- ---43-

34-

26-

HDAC3 antibody [C3], C-term (GTX109679) WB analysis with HDAC3 antibody on whole cell Iysates.

kDa t/louse bra\O 130 -

95-

72-

55-

43-

34-

26-

HDAC8 antibody (GTX113981) WB analysis with HDACB antibody on mouse brain tissue.

Toll-free: 1.877.436.3839

8 Citation

Application

ICC/IF, IHC, IHC-P, WB



ICC/IF,WB

IHC-P, WB, IHC-Wm


ELISA, ICC/IF, IP, WB

WB

IHC-P,WB

ICC/IF,WB

IHC-P, IP, WB

IHC,IP,WB

IHC, IHC-P, WB

ICC/IF,WB

FACS, ICC/IF, WB


ICC/IF,WB

WB

WB

ELlSA,WB

ICC/IF, IHC-P

ICC/IF, IHC, WB


ICC/IF, IP, WB


FACS, IHC, IHC-P, WB

FACS, ICC/IF, IHC, IHC-P, WB

IHC-P,WB

IHC,WB

HDAC4 antibody [N3C1], Internal (GTX110231) ICC/IF analysis with HDAC4 antibody on HeLa cells.

HDAC11 antibody (GTX116403) IHC-P analysis with HDAC11 antibody on H1299 xenograft.

,0 c OJ

roT

-< ~ :::l roT

0-0 Cl.

III (f)

,0 c OJ

roT

-< ;;0 III (f)

c roT (f)

,0 c OJ

0-o a. Il> (f)

,0 c OJ

;;tl Il> (f)

C

rT (f)

Histone Modifying Enzymes - Methylation


Like acetylation, methylation of histones is a fundamental epigenetic mechanism to establish, maintain, or

alter the phenotypic identity of a eukaryotic cell. Histone methylation occurs primarily on lysine and

arginine residues, and can often take the form of mono-, di-, or tri-methylated variants. Much interest has

been directed to the specific lysine methylation events on histone H3, as individual methylation sites are

associated with distinct effects on gene expression. Methylation is somewhat unique among the histone

modifications, as particular methylation events affect other chromatin-based functions even beyond

transcriptional regulation, including DNA replication, heterochromatin formation, alternative splicing,

recombination, DNA repair, and cell cycle control. The orchestration of a cell's histone methylation profile

relies on the activities of a large number of histone methyltransferases and demethylases. Though not yet

definitive, there is increasing evidence that dysregulation of the activities of these enzymes may contribute

to various cancers and neurologic disorders. The challenge for the future is to further identify and

characterize how these factors impact human disease.

Histone Lysine Methyltransferase (KMT) (8 Citation


GTX108013 EZHI antibcdy [Nl], N-term RbpAb Hu ICC/IF, IHC-P, WB EZHI

GTX89888 EZHI antibcdy, N-term GtpAb Hu ELlSA,WB GTXll0384 EZH2 antibcdy RbpAb Hu ICC/IF, WB, ChiP assay

EZH2 GTX60367 EZH2 antibcdy [GT9005] MsmAb Hu ChiP assay (8 GTX62838 EZH2 (phospho Thr487) antibcdy [EPRI410] RbmAb Hu, Ms, Rat IHC-M, IHC-P, IP, WB

GTX128164 G9a antibcdy RbpAb Hu ICC/IF, IHC-P, IP, WB

G9a GTX129153 G9a antibcdy RbpAb Hu ICC/IF, IP, WB GTX120210 G9a antibcdy [Cl C2], Intemal RbpAb Ms WB

GLP GTX83242 GLP antibcdy [1 B7B4] MsmAb Hu ELlSA,WB GTX17959 MLL antibcdy RbpAb Hu,Ms FACS, IHC-P, IP, WB GTX83091 MLL antibcdy [10F8D7] MsmAb Hu ELISA, IHC, IHC-P, WB GTX59792 MLL 1 antibocy RbpAb HU,Ms WB

MLL GTXI5962 MLL2 antibocy, N-term GtpAb Hu ELlSA,IHC-P GTX53678 MLL3 antibocy RbpAb Hu WB GTX89763 MLL4 antibocy, C-term GtpAb Hu ELISA, IHC, IHC-P GTX85719 MLL5 antibocy RbpAb Hu ELlSA,IHC-P GTX129035 SETD1A antibcdy RbpAb Hu WB GTX129036 SETD1A antibcdy RbpAb Hu WB

SETD GTX629891 SETD6 antibcdy [GT688] MsmAb Hu WB GTX117333 SETD7 antibcdy [N1Cl] RbpAb Hu WB GTXII9440 SETD8 antibcdy RbpAb Hu ICCIIF, IHC-P, WB

(8 GTX115305 SETDBI antibcdy [Nl], N-term RbpAb HU,Ms IP, WB, ChiP assay GTXll0219 SETDBI antibcdy [N2Cl], Intemal RbpAb Hu IP, WB, ChiP assay

SETDB GTX80408 SETDBI antibcdy [5H6A 12] MsmAb Hu, Ms, Mk ELISA, ICCIIF, WB GTX116932 SETDB2 antibcdy [Nl N2], N-term RbpAb Hu ICC/IF, IP, WB GTX13712 CLLD8/ SETDB2 antibcdy, N-term GtpAb Hu ELlSA,WB

SMYD GTXII9464 SMYDI antibcdy RbpAb Hu, Ms, Rat ICCIIF, IHC-P, WB GTX116510 SMYD2 antibcdy RbpAb Hu ICC/IF,WB


Histone Lysine Methy[transferase (KMT)

Cat. No.

(B GTX121945

GTX121956 SMYD

GTX628535

GTX110518 (B GTX112263

SUV39H1 GTX12405

GTX23659

34-

EZH1 antibody [N1], N-term (GTX10B013) WB analysis with EZH1 antibody on whole cell lysate of HepG2 cells.

Product

SMYD3 antibody

SMYD3 antibody

SMYD3 antibody [GT1088]

SMYD5 antibody [C2C31, C-term

SUV39H1 antibody [N3C3]

SUV39H1 antibody [44.1]

SUV39H1 antibody [42A T239.96.72]

II o.

EZH2 antibody (GTX1130B4) ChiP analysis with EZH2 antibody on chromatin extract of HeLa cells.

Protein Arginine Methyltransferase (PRMT)

PRMT1

PRMT2

PRMT3

PRMT4

PRMT5

PRMT6

PRMT7

PRMTB

PRMT9

GeneTex

Cat. No. Product

GTX128211 PRMT1 antibody

GTX128199 Prmt1 antibody

GTX630186 PRMT1 antibody [GT779]


GTX103749 PRMT2 antibody [N1C2]



GTX115367 PRMT3 antibody [C1C3]


GTX12190 PRMT3 antibody [PRMT3-3671

GTX129040 CARM1 antibody



GTX80395 CARM1 antibody [3H21

GTX13707 PRMT 4 antibody

GTX115994 PRMT5 antibody [N1 N3]





GTX82806 PRMT6 antibody [4G2]

GTX47433 PRMT6 antibody, Intemal



GTX47432 PRMT7 antibody, N-term

GTX47431 PRMT8 antibody, C-term

GTX46904 FBX011 antibody, Intemal

International USA

Tel: 886.3.6208988 Tel: 1.949.553.1900

Histone Modifying Enzymes - Methy[ation


RbpAb Hu, Ms

RbpAb Hu

MsmAb Hu

RbpAb Hu

RbpAb Hu, Ms

MsmAb Hu, Ms

MsmAb Hu

kDa # ~""ro «'J.. ~' ~v ~()

170-

130 - --72-

55-

43-

EZH2 antibody (GTX1130B4) WB analysis with EZH2 antibody on whole cell Iysates.


RbpAb Hu

RbpAb Zfsh

MsmAb Hu, Ms

MsmAb Hu, Ms

RbpAb Hu

RbpAb Hu

RbpAb Hu

RbpAb Hu, Ms

RbpAb Hu, Ms

MsmAb Hu, Ms, Rat

RbpAb Hu

RbpAb Hu, Ms, Rat

RbpAb Hu, Ms, Rat

MsmAb Hu, Mk, Rat

RbpAb Hu, Ms

RbpAb Hu

RbpAb Hu

RbpAb Hu

MsmAb Hu, Rat

RbpAb Hu

MsmAb Hu, Mk

RbpAb Hu

RbpAb Hu, Ms, Rat

RbpAb Hu

RbpAb Hu, Ms, Rat

RbpAb Hu, Ms, Dog, Rat

RbpAb Hu, Ms, Rat

Toll-free: 1.877.436.3839

II

(BCitation

Application



IHC-P, WB

IHC-P, WB


ELISA, ICC/IF, IHC, IP, WB

ELlSA,WB

kDa ,l "'~ ~"- " -t ~<? ~.q .p 250-

:::J

130 -

95-

72-

G9a antibody (GTX12B164) WB analysis with G9a antibody on whole cell Iysates.

(BCitation

Application

ICC/IF,WB

IHC-Wm

ICC/IF,WB

WB

ICC/IF, IHC-P, WB

ICC/IF,WB

ELISA, IHC-P, WB, ChiP assay

ICC/IF,WB

IP,WB

ELISA, ICC/IF, WB

IHC-P,WB

ICC/IF,WB

ICC/IF,WB

ELISA, FACS, ICC/IF, IHC, IHC-P, WB

WB

ICC/IF, IHC-P, WB

ICC/IF, IHC-P, WB


IP,WB

ICC/IF, IP, WB

ELlSA,WB

WB


WB

WB

WB

WB

,0 C OJ

CJ o 0-

ro (f)

,0 C OJ

;;0 ro (f)

c rT (f)

,0 C OJ

...... -< ~ :::l ...... 0-0 a. ro (f)

,0 c OJ

...... -< ;;0 ro (f)

c ...... (f)


kDa ~,{o' ~ #~ '" ,,'" c,V' i ' # . v,.,

130 -

100 -70-

55-

-35-

25-

PRMT1 antibody [GT779] (GTX630186) WB analysis with PRMT1 antibody on whole cell Iysates.

PRMT2 antibody [N1C2] (GTX103749) ICCIIF analysis with PRMT2 antibody on A431 cells.

Histone Lysine Demethylase (KDM)

KDM2B

KDM3A

KDM3B

KDM4A

KDM4B

KDM4C

KDM6A

JARID1C

JHDM1A

JMJD3

JMJD4

JMJD5 JMJD6

LSD1

70.

60.

]j 50 .§ 40. ()

§ 30. Q)

~ 20 10.

Cat. No.

GTX104868

GTX25199

GTX85253 GTX80407

GTX80407

GTX116198 GTX116429

GTX82792

GTX50909 GTX53804

GTX84280

GTX84279

GTX121246 GTX120873

GTX630412

GTX110045 GTX109831

GTX82550

GTX82551 GTX124222

GTX85252

GTX85251 GTX110746

GTX115660

GTX83263 GTX60362

64.17 • RBL1

1.00 O.U-i-------,-

rabbit IgG

KDM6A antibody [N2C1], Internal (GTX121246) ChiP analysis with KDM6A antibody on chromatin extract of HeLa cells.

Product

FBXL 10 antibody IC3], C-terrn FBXL 10/ PCCX2 antibody, C-term

JMJD1A antibody KDM3A antibody [1 E 12]

KDM3A antibody [1 E 12]

KDM3B antibody [C2C3], C-term KDM4A / JHDM3A / JMJD2A antibody [N1 N3]

KDM4A antibody [5H 1]

KDM4B antibody

JMJD2B antibody KDM4C antibody [5B9]

KDM4C antibody [4B 1]

KDM6A antibody [N2C1], Intemal KDM6A antibody [C2C3], C-term

KDM6A antibody [GT1612]

JARID1C antibody [N1N2-2], N-term JARID1C antibody [N1N2], N-term

JHDM1 alFBXL 11 antibody, Intemal

JHDM1 alFBXL 11 antibody, N-term JMJD3 antibody [C2], C-term

JMJD4 antibody

JMJD5 antibody

PSR antibody LSD1 antibody

LSD1/AOF2 antibody [1B2E5] LSD1 antibody -ChiP grade

JARID1 C antibody [N1 N2], N-term (GTX109831) WB analysis with JARID1C antibody on whole cell lysate of A431 cells or HeLa cells.


KDa ~').

170-~c;

130 -

95-

72- -55-

43-

PRMT3 antibody [C1C3] (GTX115367) WB analysis wilh PRMT3 antibody on whole cell lysate of MCF-7 cells.


RbpAb Hu.Ms

GtpAb Hu

RbpAb Hu, Ms, Rat

MsmAb Hu

MsmAb Hu

RbpAb Hu

RbpAb Hu

MsmAb Hu

RbpAb Hu

RbpAb Hu

MsmAb Hu

MsmAb Hu

RbpAb Hu

RbpAb Hu

MsmAb Hu

RbpAb Hu

RbpAb Hu

RbpAb Hu

RbpAb Hu

RbpAb Hu

RbpAb HU,Rat

RbpAb Hu, Ms, Rat

RbpAb HU,Ms

RbpAb Hu

MsmAb Hu, Ms, Mk

RbpAb Hu

JMJD3 antibody [C2], C-term (GTX124222) WB analysis with JMJD3 antibody on whole cell lysate of 293T cells or A375 cells.

r 4.

3.

C 3.

~ 2 .t:::

.g 2. a; 1.

" :E 1.

o. o.

PRMT5 antibody [N1C1] (GTX116004) ChiP analysis with PRMT5 antibody on chromatin extract of K562 cells.

Application

WB ELlSA,WB ELISA, ICC/IF, IHC, WB



IP,WB

WB ELISA, ICC/IF, IHC, IHC-P, WB

WB FACS, IHC, IHC-P, WB


FACS, ICCIIF, IHC, IHC-P

$ Citation


WB

WB

WB

WB ELISA, IHC, IHC-P, WB

ELlSA,WB IHC-P,WB

ELISA, ICCIIF, IHC, WB ELISA, ICC/IF, IHC, WB

IHC-P,WB

WB ELISA, IHC, IHC-P, WB

WB, ChiP assay

KOa ""n,1>,.

130 -95-72- __

55-

43-

34-

26-

PSR antibody (GTX11 0746) WB analysis with PSR antibody on whole cell lysate of A431 cells.

G GeneTex

International Tel 886.3.6208988 Fax 886.3.6209098

E-mail [email protected]

USA Tel 1.949.553.1900 Fax 1.949.309.2888

Toll-free 1.877.436.3839 E-mail [email protected]

www.genetex.com

www.ge netex.com

PB-E004-141002

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