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Bürgi Effect rgi Effect Different pharmacologically active substances mixed together have a potentiating mixed together have a potentiating synergistic effect 1 © Dipartimento Scientifico Guna S.p.a.

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BBüürgi Effectrgi Effectgg

Different pharmacologically active substances mixed together have a potentiatingmixed together have a potentiating

synergistic effect

1© Dipartimento Scientifico Guna S.p.a.

TRAUMATOLOGYTRAUMATOLOGY-- GENERAL PARTGENERAL PART

2

Chamomilla 1X*•Organotrophism and

GUNAGUNA®®--TRAUMA TRAUMA dropsdrops

Chamomilla 1X*Hypericum 3X*

Arnica 3X**Hamamelis 2X**

Bellis 2X***

•Organotrophism andcarrier function forhomologous humantissues Bellis 2X

Calendula 1X****Symphytum 3X****

Ruta 3XKalmia 8XC ti 12/30/200X Kalmia 8X

Rhus tox. 6XBryonia 6X

Connective 12/30/200XBone 12/30/200X

Cartilago 12/30/200X

•Modulation of all inflammatory process development phases (neurogen*, vasal**, PNEI COREexudative***, restitutio ad integrum****)

•Tropism remedies, specific for bones muscles tendons

•Stop to IL1, starter of inflammatory process*

•The stimulation of the for bones, muscles, tendons, ligaments, synovia

•Activity aimed at all the functional components of

Anti IL 1 4C*

TGF-beta 1**

IL 10**

cytokines having Th2-Th3 polarity modulates inflammation**

3

ortho-traumatologic painBeta-Endorphin 6X***

•Analgesic action***

© Dipartimento Scientifico Guna S.p.a.

• SYMPTOMS CONTROLACONITUM 6/12/30/200X

GUNAGUNA®®--FLAM FLAM dropsdrops

ACONITUM 6/12/30/200XAPIS 6/12/30/200XBELLADONNA 6/12/30/200XFERRUM PHOSP. 6/12/30/200X

• DRAINAGE

CONNECTIVE TISSUE 12/30/200X

d

HEPAR SULF. 6/12/30/200XPYROGENIUM 30/200XBRYONIA 6/12/30/200XPHYTOLACCA 6/12/30/200X Homeopathic and

Classic

and PHYTOLACCA 6/12/30/200X

• CELL METABOLIC SUPPORT• CELL NUTRITIONAL

SUPPORT

Homeopathic andHomotoxicological

Remedies

Vit iMinerals,

,

, COPPER GLUCONATE 4X

NATRUM PYRUVICUM 3X

ACIDUM CITRICUM 3X

SUPPORT

Proteinsynthesis

Antioxidative

Oligonutrients

Cytokines,

Trace elements

Vitamins,

, protectiony

HomeopathicNeurotransmitters

Hormones,

• P.N.E.I. REBALANCE

ANTI IL 1 4C TGF β 1 4C IL 10 4C

4

ANTI-IL 1 4C TGF- β 1 4C IL 10 4C

MELATONINE 6X β-ENDORPHIN 6X HYPOPHYSIS 200X

PINEAL GLAND 6X© Dipartimento Scientifico Guna S.p.a

GUNAGUNA®®--MATRIX MATRIX dropsdrops

• DRAINAGE- PYROGENIUM 12X

• SYMPTOMS CONTROL

- FUCUS 3X- THUJA 8X- NATRUM SULFURICUM 8X- CONJUNCTIVA TISSUE 6X- LYMPHATIC VESSELS 6X

Modulating local or systemicphlogosisinflammation

H thi dClassic

C SS S 6- HYALURONIDASE 6X

• CELL • CELL

Homeopathic andHomotoxicological

RemediesMinerals,

METABOLIC SUPPORT

- ASCORBIC ACID 2X

CELL NUTRITIONAL

SUPPORTTYROSINE 2X

Oligonutrients

Cytokines,

Trace elements

Vitamins,

, ,

ASCORBIC ACID 2X

- KREBS CYCLECATALYSTS 6X

- TYROSINE 2X

- PHENYALANINE 2X

- HISTIDINE 2X

Cytokines,

HomeopathicNeurotransmitters

Hormones,

• P.N.E.I. REBALANCEIL 6 4C

5

- IL 6 4C

- PROLACTINE 6X

- DHEA 6X© Dipartimento Scientifico Guna S.p.a.

R d i f l l

MyosotisEquisetumHydrocotileTaraxacum

D-L Malic Ac./Fumaricum Ac./Pyruvicum Ac.Trychinoil/Natrium oxalac.

GUNAGUNA®®--LYMPHO LYMPHO dropsdrops

•Lymphagogue action and stabilization of vasal

•Reduction of local inflammation on

lymphoepithelial tissues

• Reduction of lymphatic

TaraxacumSarsaparilla

Lymphatic vesselCapillary tisssue

L-Thyroxin walls tone with consequent reduction of

exudate and lymphoedema

Reduction of lymphatic spasm on inflammatory basis with consequent

restoration of the lymphatic circulation REACTIVATION OF THE

L-ThyroxinVena

lymphatic circulation C O OLYMPHATIC

CIRCULATION

HYPERTROPHYHydrastisJ lHYPERTROPHY

AND HYPERPLASY OF LYMPHATIC

ORGANS

ANTI-INFLAMMATORY ACTIVITY ON

LYMPHOEPITELIAL TISSUES

JuglansGraphitesCalendula

PhytolaccaApis

M i h h

•Hindrance to the proliferative proneness ofl i i

STRENGHTENING OF THE IMMUNE

DEFENCE

Magnesia phosph.

proliferative proneness of lymphoepitelial tissues

•Humoral immunity stimulation and

inhibitory modulation of the excessive cell

di dMagnesium

phosphoricum

6

mediated compensatory

response

phosphoricum

Juglans regia

© Dipartimento Scientifico Guna S.p.a.

TRAUMATOLOGYTRAUMATOLOGY - MUSCULAR LESIONS1

EXTERNAL CAUSES = MUSCULAR CONTUSION acute pain, swelling, painful tumefaction,

:p ,(in case) hematoma

THERAPYTHERAPY

- GUNA®-MUSCLE AMPOULES + GUNA®-NEURAL AMPOULES- GUNA®-TRAUMA DROPS

DROPS:

10 drops 3 times a day,

- GUNA®-MATRIX DROPS- GUNA®-FLAM DROPS

p y,15 minutes before meal

INTERNAL CAUSES = MUSCLE ELONGATION – MUSCULAR CONTRACTION - STRETCHING

THERAPYTHERAPYTHERAPYTHERAPY

- GUNA®-MUSCLE AMPOULES + GUNA®-NEURAL AMPOULES

7- GUNA®-TRAUMA DROPS- GUNA®-LYMPHO DROPS

© Dipartimento Scientifico Guna S.p.a.

TRAUMATOLOGYTRAUMATOLOGY - TENDINITIS 80% in Sport Medicine

2

TENDINITIS: edema, heat, tendon stiffness• tendinitis

t d iti• tendosynovitis • tendoperiostitis• etc.

THERAPYTHERAPY

1) CALCANEAN TENDON:- GUNA®-HAND/FOOT AMPOULES

2) BICIPITAL TENDINITIS:

- GUNA®-SHOULDER AMP. + GUNA®-MUSCLE AMP.- GUNA®-MATRIX DROPS- GUNA®-FLAM DROPS

- GUNA®-FLAM DROPS- GUNA®-MATRIX DROPS

4) PUBIC PAIN:3) TENDON PAIN FROM CASTS:- GUNA®-HIP AMPOULES- GUNA®-FLAM DROPS- GUNA®-LYMPHO DROPS

- GUNA®-HANDFOOT AMPOULES- GUNA®-MATRIX DROPS- GUNA®-LYMPHO DROPS

8- GUNA®-MATRIX DROPS

© Dipartimento Scientifico Guna S.p.a.

TRAUMATOLOGYTRAUMATOLOGY - FRACTURES3

- OSTEOBIOSTM DROPSGUNA® ARTHRO DROPS

THERAPYTHERAPY- GUNA®-ARTHRO DROPS- GUNA®-MATRIX DROPS- GUNA®-FLAM DROPS

G ® O S+ GUNA®- ….. AMPOULES according to the anatomic localization(e.g. fracture of femor neck: GUNA®-HIP, fracture of hand bones: GUNA®-HANDFOOT)

- DISLOCATIONS

THERAPYTHERAPY

- GUNA®-FLAM DROPS- GUNA®-ARTHRO DROPS- GUNA®-MATRIX DROPS- GUNA®-LYMPHO DROPS - in case of shoulder dislocation: add

GUNA®-SHOULDER AMPOULES

9© Dipartimento Scientifico Guna S.p.a.

TRAUMATOLOGYTRAUMATOLOGY - PERIPHERAL NERVE LESIONS

4

THERAPYTHERAPY

- GUNA®-NEURAL AMPOULESCOMPRESSION SYNDROMES

- GUNA®-FLAM DROPS

- GUNA®-MATRIX DROPSSPRAIN SYNDROMES (BRACHIAL PLEXUS)

POSTOPERATIVE PARESIS- GUNA®-TRAUMA DROPS

- SYNDROMES DUE TO HYPEREXTENSION-HYPERFLEXION

THERAPYTHERAPY- GUNA®-NECK AMPOULES

THERAPYTHERAPY- GUNA®-THORACIC AMPOULES

- GUNA®-LUMBAR AMPOULES

10© Dipartimento Scientifico Guna S.p.a.

11

FIBROMYALGIAFIBROMYALGIA

Fibromyalgia is not a new syndrome but a resurrection of the old “diagnosis” fibrositis

Fibromyalgia syndrome is a very common chronic illness whose pathogenesis is reported to be poorly understood

Women are more affected than men

All races are affected

12

FIBROMYALGIAFIBROMYALGIADIAGNOSIS: the patient has to constantly experience the symptomsfor more than 3-4 months and have at least 10 Trigger Pointsgginto the 18 classical sites + disturbed sleep

Commonly associated conditions: irritable bowel syndrome, migraine,phychic depression, obstructive sleep apnoea, general fatigue

Several causes have been identified: stress, tension, chill, , , ,connective tissue diseases such as

1) osteoarthritis, nerve compression, endocrine imbalance (estrogen deficiency hypothyroidism)(estrogen deficiency, hypothyroidism)

2) traumas, repetitive strain, overuse

3) physical-mental fatigue anxiety3) physical-mental fatigue, anxiety

LAB TESTS AND X-RAY: NEGATIVE FOR SPECIFIC DIAGNOSIS

13© Dipartimento Scientifico Guna S.p.a.

THE 18 POINTS TO TESTTHE 18 POINTS TO TEST

POSITIVE POINT: needs to be painful to a of 4Kg/cm2 pressure applied by the examiner’s digit

POSITIVE POINT: needs to be painful when the applied thumb p pppressure is sufficient to blanchthe nail-bed of the doctor’s thumb when he/she pressesthumb when he/she presses firmly on the part

14© Dipartimento Scientifico Guna S.p.a.

FIBROMYALGIA SYNDROMEFIBROMYALGIA SYNDROME

LOCALLOCALTHERAPYTHERAPY

GUNA®-MUSCLE + GUNA®-NEURAL2 ampoules (4 ml) + 1 ampoule (2 ml) =2 ampoules (4 ml) + 1 ampoule (2 ml)

6 ml

INTO EACH TRIGGER POINT: 0.5 ml

TRIGGER POINTS INJECTED PER SESSION: 10 - 12

NUMBER OF SESSIONS: 8 - 10

15© Dipartimento Scientifico Guna S.p.a.

NUMBER OF SESSIONS: 8 10

FIBROMYALGIA SYNDROMEFIBROMYALGIA SYNDROME

HOMEHOMETHERAPYTHERAPY

GUNA®-FLAM DROPS 15 drops 3 times a day 9am – 3pm – 9pm

Example:

GUNA®-MATRIX DROPS 15 drops 3 times a day 9.30am – 3.30pm – 9.30pm

®GUNA®-SLEEP DROPS 15 – 20 drops a day 10.30 pm

Duration of the therapy: 2 months

16© Dipartimento Scientifico Guna S.p.a.

PRACTICAL SOLUTIONS TOPRACTICAL SOLUTIONS TOPRACTICAL SOLUTIONS TO PRACTICAL SOLUTIONS TO YOUR DAILY PRACTICE IN YOUR DAILY PRACTICE IN

GENTLE & EFFECTIVE GENTLE & EFFECTIVE PAIN MANAGEMENTPAIN MANAGEMENTPAIN MANAGEMENTPAIN MANAGEMENT

THE TOP TEN IN PAIN CONTROLTHE TOP TEN IN PAIN CONTROLTHE TOP TEN IN PAIN CONTROLTHE TOP TEN IN PAIN CONTROL

17

SYNERGISM: the remedies boost each other in a synergistic way. The global effect is higher than the single remedy effect

BALANCE: in the medicines, remedies are contained in quantities and diluitions to re-balance, without altering, the neuro-quantities and diluitions to re balance, without altering, the neuroimmune-endocrine homeostasis

COMPLETENESS: the remedies are associated so that everyCOMPLETENESS: the remedies are associated so that every step of the etiopathogenetic cascade and every possible symptomatologic expression the medicine is indicated for is considered

18© Dipartimento Scientifico Guna S.p.a.

PAIN MANAGEMENTPAIN MANAGEMENT

LOCAL THERAPYLOCAL THERAPY-- LOCAL THERAPY LOCAL THERAPY --

19

Select application site according to Type of needle

acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapictechnique.

GUNA®-NECK

Chart of area/zone connections

GUNA®-SHOULDER

GUNA®-THORACIC

GUNA®-HIP

GUNA®-LUMBAR

GUNA®-ISCHIALGUNA ISCHIAL

GUNA®-HANDFOOT

GUNA®-POLYARTHRITISJoint pain

GUNA®-MUSCLEMuscle pain

GUNA®-NEURALNerve pain

ANATOMICAL STRUCTURE OF AN ACUPOINTANATOMICAL STRUCTURE OF AN ACUPOINT

22

GUNAGUNA®®--NECKNECKClinical Indications

GUNAGUNA®® NECKNECKClinical Indications

Neck pain due to cartilage degenerative i l i di d ( i l t th i )cervical spine disorders (cervical osteoarthrosis)

Neck pain due to cervical muscular trigger pointspoints

Stiff neck syndromeSimple neck painp pWhiplashPostural neck acheM h i l i b l (f t j i t d )Mechanical imbalance (facet joint syndrome) Cervical spinal ligament syndrome Cervical spinal nerve root pain

23

Cervical spinal nerve root painArnold syndrome

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Cartilago suis 4X HPUS 4 parts; Anti interleukin 1 alpha 4C Antiparts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Magnesia phosphorica 8X HPUS NuxMagnesia phosphorica 8X HPUS, Nux vomica 10X HPUS, Picricum acidum 10X HPUS Silicea 4X HPUS 2 parts; CrotalusHPUS, Silicea 4X HPUS 2 parts; Crotalus horridus 10X HPUS, Intervertebral disk, Porcine 4X 1 partPorcine 4X 1 part.

Inactive ingredient: Sterile isotonic sodiumInactive ingredient: Sterile isotonic sodium chloride solution.

24© Dipartimento Scientifico Guna S.p.a.

• Magnesia phosphorica 12X•Picricum ac. 8X

• Crotalus horridus 10X

GUNA®-NECK

Reduction of cervical rachis pain

• Beta-Endorphin 4C • Nux vomica 10X

•• Riduzione della sintomatologia Riduzione della sintomatologia algica per UPalgica per UP--REGULATION dei REGULATION dei recettori della recettori della β––EndorfinaEndorfina

psymptomatology of

different origin:• Fibromyalgic origin (Picricum acidum)

•• Pain symptomatology reduction by Pain symptomatology reduction by means of UPmeans of UP--REGULATION ofREGULATION ofβ––Endorphin receptorsEndorphin receptors

P.N.E.I. P.N.E.I. Homeopathic Homeopathic • Spastic and/or congestive origin (Crotalus horr., Nux vomica, Magnesia phosph.)• Stimulation of osteoblasts AntiAnti--

degenerativedegenerative

antalgic coreantalgic core antalgic coreantalgic core

AntiAnti--inflammatoryinflammatory phosph.)

• Nevralgic origin (Magnesia phosph.)

Anaesthetic origin:• Picricum acidum

function and correction of articular structure pathologies

degenerative degenerative core 2core 2

inflammatory inflammatory corecore

AntiAnti--degenerative degenerative

core 1core 1 Picricum acidum

• Anti interleukin 1 alpha 4C

• Anti interleukin 1 beta 4C• Silicea 4X

• Modulation of IL1 α and IL1β pro-inflammatory activity in the trigger phase of

• Biostimulation cartilage matrix components synthesis (Cartilago)

• Cartilago suis 4X

•Intervertebral disk, Porcine 4X

25

the trigger phase of inflammation• Anti-degenerative action

(Discus intervertebralis)

© Dipartimento Scientifico Guna S.p.a.

26

27

INTERLEUKIN 1INTERLEUKIN 1

Interleukin 1 (IL 1) is a cytokine secreted by different typeInterleukin 1 (IL-1) is a cytokine secreted by different type of cells of the Immune System (macrophages, monocytes, dendritic cells, fibroblasts and endothelial cells)

IL-1 = first discovered

IL-1 has various effects on the organism both at general and localIL 1 has various effects on the organism both at general and local levelOne of these effects is to support inflammatory processes; moreover it stimulates prostaglandins production from different p g ptype of cells (muscular, epithelial, etc.), the production of other cytokines (among which IL-2) and the activation and recruitment of other cells of the Immune System:y-IL-1α-IL-1 β

Those two classes have similar activities but different structures

© Dipartimento Scientifico Guna S.p.a.

INTERLEUKIN 1INTERLEUKIN 1IL 1 IS A PIVOTAL PRO‐INFLAMMATORY CYTOKINE CENTRALLY 

INVOLVED IN IMMUNE SYSTEM SYSTEMIC AND LOCAL RESPONSES 

LEADING TO TYPICAL EFFECTS OF INFLAMMATIONLEADING TO TYPICAL EFFECTS OF INFLAMMATION

DYSREGULATED, PROLONGED SYNTHESIS AND RELEASE OF IL 1 IN 

CHRONIC INFLAMMATORY SITUATIONS CONTRIBUTE TO A NUMBERCHRONIC INFLAMMATORY SITUATIONS CONTRIBUTE TO A NUMBER 

OF DISEASES,                           e.g. RHEUMATOID ARTHRITIS

IL 1IL 1

ACTIVATES ACTIVATES MONOCYTES/ MONOCYTES/

MACROPHAGESMACROPHAGES

INDUCES INDUCES FIBROBLASTSFIBROBLASTS

PROLIFERATIONPROLIFERATION

ACTIVATES ACTIVATES CHONDROCYTESCHONDROCYTES

ACTIVATES ACTIVATES OSTEOBLASTSOSTEOBLASTSMACROPHAGESMACROPHAGES PROLIFERATIONPROLIFERATION

INFLAMMATIONINFLAMMATION SYNOVIAL SYNOVIAL PANNUS PANNUS

CARTILAGE CARTILAGE BREAKDOWNSBREAKDOWNS

BONE BONE RESORPTIONRESORPTION

FORMATIONFORMATION

© Dipartimento Scientifico Guna S.p.a.

Why use Anti Interleukins (1) Alpha and Beta in the pain management formulas?

Interleukins 1 (IL1α; IL1ß) are the most active primary mediators from a biological point of view, secreted by Th1 cells to induce inflammation (Phase A) by means of their own capacity to stimulate the genic expression associated with the whole inflammatory process evolution

‐ Even though structurally different (codified by 2 different genes), they act on the same specific receptor. IL1 have a very short half‐life and are secreted by IL1 themselves when in contact with CD4 lymphocytesthemselves when in contact with CD4 lymphocytes

IL1 (α; ß) activate cyclooxygenase type 2 (COX2) (A), prostaglandin E2 (B) and nitric oxide (C) so activating the inflammatory process (pro‐inflammatory Interleukins)oxide (C), so activating the inflammatory process (pro‐inflammatory Interleukins)

►As a consequence, Anti Interleukins 1 (α; ß) act as NSAIDs (A), cortisone (B) and, in part, as salicylates (C), without the negative side effects caused by these allopathicpart, as salicylates (C), without the negative side effects caused by these allopathic medicines. Consequently, homeopathically diluted Anti IL1 α and ß are successfully used in osteo‐arthro‐myalgic pain management therapy (according to Physiological Regulating Medicine – Guna Method)g g )

© Dipartimento Scientifico Guna S.p.a.

What is the scientific reason for using Anti Interleukins and not Interleukins having anti inflammatory properties?having anti‐inflammatory properties?

Anti inflammatory Interleukins (mainly IL10)Anti‐inflammatory Interleukins (mainly IL10) are secreted by Th2 cells after the activation of Th1 cells (Phase B of Hoff’s Commutativeof Th1 cells (Phase B of Hoff s Commutative Reaction) and, as a consequence, they act after Interleukins 1 α and ß secretion

The block of Interleukins 1 α and ß (anti) is therefore moreThe block of Interleukins 1 α and ß (anti) is therefore more effective than the stimulation of IL10

IL10 has more anti‐inflammatory action above all in chronic forms than in acute formsforms than in acute forms

© Dipartimento Scientifico Guna S.p.a.

INFLAMMATIONINFLAMMATION

PHASE A = DEVELOPMENTPHASE A = DEVELOPMENT PHASE B = RESOLUTIONPHASE B = RESOLUTION

YESYES NONO

CHRONICIZATIONCHRONICIZATIONRECOVERYRECOVERY CHRONICIZATIONCHRONICIZATIONRECOVERYRECOVERY

© Dipartimento Scientifico Guna S.p.a.

&&

inflammation reduction(mesenchyme synthesis, tissue alkalosis sympathetic tone

inflammation development(mesenchyme hydrolysis, tissue acidosis sympathetic tone pro alkalosis, sympathetic tone, 

anti‐inflammatory cytokines release: IL10, TGF β 1, etc.)

acidosis, sympathetic tone, pro‐inflammatory cytokines release: IL1α, IL1β, TNFα, IL12, IL15, IL18 INF INF β)IL18, INFα, INF β)

Phase A can last some hours‐days (acute inflammation: inflammation; sub acute inflammation; inflammation plus; chronic inflammation)

The duration of Phase A depends upon: 1) damage level2) patient’s immunoregulation) li d i f h h3) quality and quantity of the therapy

© Dipartimento Scientifico Guna S.p.a.

ENDORPHINENDORPHINENDORPHINENDORPHIN

Endorphins are organic chemical substances produced by the CNS having antipain andproduced by the CNS, having antipain and physiological characteristics similar to those of morphine and opium – however they haveof morphine and opium – however they have a wider range

Endorphins, like a number of morphinic origin alkaloids can cause states of euphoriaorigin alkaloids, can cause states of euphoria and somnolence according to the quantity releasedreleased

© Dipartimento Scientifico Guna S.p.a.

Physiological Regulating Medicine Physiological Regulating Medicine in Pain Managementin Pain Management

Homeopathic microdoses:p• guarantee lack of negative side-

ff teffects • avoid troubles concerning toleranceavoid troubles concerning tolerance• avoid pharmacological catabolites

overload in extracellular matrix and organsorgans

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Neck + Guna®-Muscle: neck pain due to cervical trigger points muscle-Guna -Neck + Guna -Muscle: neck pain due to cervical trigger points, muscle-tensive occipital frontal headache, whiplash.

Guna®-Neck + Guna®-Neural: brachialgia from cervical arthrosis, cranic neuritisGuna Neck Guna Neural: brachialgia from cervical arthrosis, cranic neuritis caused by atlo-epistrophic dislocation, muscle-tensive headache, lost of physiological cervical lordosis.

Guna®-Neck + Guna®-Polyarthritis: cervical syndrome caused by rheumatoid osteoarthritis or other autoimmune diseases, cervical syndrome caused by general somatic pain.

Guna®-Neck + Guna®-Arthro: cervical arthrosis, cervical articular discomfort.

37Guna®-Neck + Guna®-Trauma: post-surgery recovery, cervical contusions in traumatology and sport medicine.

into specific and selectedGUNA®-NECK into specific and selected

local Acupuncture Points

GUNA NECK

GB 21

GV 16

GB 20 SI 10BL 10

GV 15

GB 21 SI 9

SI 10

GV 14

38

into Trigger Points and referredGUNA®-NECK into Trigger Points and referred pain zones

GUNA NECK

BL 10TP

S

BL 11

TP

SI 15

TP/SI 14

C 7 C 7

TP = Main Trigger Points and correlated Acupuncture points

39

Treatment

Standard protocol for i.m. administration:

Treatment

1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1

40treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

41© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--THORACICTHORACICGUNAGUNA®® THORACICTHORACICClinical IndicationsClinical Indications

Thoracic pain due to cartilage degenerative thoracic spine disorders (thoracicthoracic spine disorders (thoracic osteoarthrosis)

Thoracic pain due to scoliosis h i i d h i l lThoracic pain due to thoracic long muscle

trigger points Pain due to thoracic spine osteophytosis Simple posterior thoracic pain (thoracic pain

syndrome)Mechanical imbalance (costo-vertebral facet (

joint syndrome)Thoracic spinal ligament syndromeThoracic spinal nerve root pain

42

Thoracic spinal nerve root pain Pain from spinal osteoporosis

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Chininum sulphuricum 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Calcarea phosphorica 6X HPUS, Cimicifuga racemosa 4X HPUS, Intervertebral disk, Porcine 4X, Spongia tosta 10X HPUS 2 parts; Chelidonium majus 4X HPUS, Conium maculatum 6X HPUS 1 part.

Inactive ingredient: Sterile isotonic sodium chloride solution.

43© Dipartimento Scientifico Guna S.p.a.

•Chelidonium majus 4X•Cimicifuga racemosa 4X•Conium maculatum 6X

Chi i l h i 8X

GUNA®-THORACIC

Reduction of the dorsal rachis pain

• Beta-Endorphin 4C

•Chininum sulphuricum 8X•Spongia tosta 10X

•• Riduzione della sintomatologia Riduzione della sintomatologia algica per UPalgica per UP--REGULATION dei REGULATION dei recettori della recettori della β––EndorfinaEndorfina

rachis pain symptomatology of

different origin, type and localization:

Neuro-muscular i i (Ci i if

•• Pain symptomatology reduction by Pain symptomatology reduction by means of UPmeans of UP--REGULATION ofREGULATION ofβ––Endorphin receptorsEndorphin receptors

P.N.E.I. P.N.E.I. Homeopathic Homeopathic origin(Cimicifuga,

Chininum sulph., Conium)•Spastic and/or congestive origin(Chelidonium, Spongia)•Constitutional correction of ConstitutionalConstitutional

antalgic coreantalgic core antalgic coreantalgic core

AntiAnti--inflammatoryinflammatory Spongia)

LOCALIZATIONDorsal rachis: direct, all; hepatic reflex, Chelidonium. Intercostal pain: Spongia

articular structure pathologiesConstitutional Constitutional

corecoreinflammatory inflammatory

corecoreAntiAnti--

degenerative degenerative corecore Intercostal pain: Spongia

• Anti interleukin 1 alpha 4C

• Anti interleukin 1 beta 4C• Calcarea phosphorica 6X

• Anti interleukin 1 beta 4C

•Intervertebral disk, Porcine 4X• Modulation of IL1 αand IL1 β pro-

44•Anti-degenerative and anti-neuralgic action

© Dipartimento Scientifico Guna S.p.a.

and IL1 β proinflammatory activity in the trigger phase of inflammation

Most common combinations:

Guna®-Thoracic + Guna®-Muscle: thoracic pain due to scoliosis and thoracic long muscle trigger points, pain of the deep paravertebral thoracic muscles.

Guna®-Thoracic + Guna®-Neural: intercostal pain, post-herpetic thoracic neuritis, thoracic spinal nerve root pain.

Guna®-Thoracic + Guna®-Polyarthritis: thoracic syndrome caused by rheumatoid osteoarthritis, general thoracic pain.

Guna®-Thoracic + OsteobiosTM: thoracic vertebral fractures, thoracic vertebral slow healing.

45Guna®-Thoracic + Guna®-Arthro: general thoracic osteoarthrosis.

GUNA®-THORACIC into specificGUNA THORACIC into specific

local Acupuncture Points

GB 20

BL 10BL 41 BL 13

BL 12

BL 11 Selected according to the most painful area (max 10 points each treatment)BL 41

BL 42SI 10

BL 17BL 16

BL 15

BL 14BL 13 treatment)

BL 20

BL 19BL 18

Ex YishuBL 17

GB 30

BL 21

BL 20

GB 30

46

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

47treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

48© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--LUMBARLUMBARGUNAGUNA®® LUMBARLUMBARClinical Indications

Lumbar pain due to cartilage degenerative lumbar spine disorders (lumbar and lumbar-sacral arthrosis)sacral arthrosis)

Lumbar vertebral osteophytosis Low back pain due to muscular and

t di t i i ttendinous trigger points Simple lumbar pain (low back syndrome) Weak low back syndromePostural low back acheLumbar and lumbar-sacral mechanical

imbalanceLumbar and lumbar-sacral spinal ligament

syndromeSacro-iliac syndrome

49

Sacro iliac syndrome Spinal lumbar and lumbar-sacral nerve root

pain© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Alumina 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Beta-parts; Anti interleukin 1 alpha 4C, BetaEndorphin 4C, Bryonia alba 4X HPUS, Hamamelis virginiana 6X HPUS, NatrumHamamelis virginiana 6X HPUS, Natrum sulphuricum 8X HPUS, Phosphoricum acidum 6X HPUS, Sepia 4X HPUS 2 parts;acidum 6X HPUS, Sepia 4X HPUS 2 parts; Anti interleukin 1 beta 4C, Intervertebral disk, Porcine 4X 1 part.Intervertebral disk, Porcine 4X 1 part.

Inactive ingredient: Sterile isotonicInactive ingredient: Sterile isotonic sodium chloride solution.

50© Dipartimento Scientifico Guna S.p.a.

Reduction of the lumbar Reduction of the lumbar rachis pain symptomatology rachis pain symptomatology of different origin, type and of different origin, type and

localization:localization:

GUNA®-LUMBAR•Neuro-muscular origin (Bryonia, Alumina, Ac. Phosphoricum). Articular origin (Natrium sulph.)

•Beta-Endorphin 4C

•Pain symptomatology reduction by means of UP-REGULATION ofβ–Endorphin receptors

•Type – cramp-like pain (Ac. phosphoricum); muscular paresis phenomena (Alumina) P.N.E.I.P.N.E.I. β p p

•Localization – Lumbosacral rachis: direct, Hamamelis; abdominal reflex, Sepia

Antalgic coreAntalgic core

AntiAnti--HomeopathicHomeopathic

•Anti interleukin 1 alpha 4C

•Anti interleukin 1 beta 4C

inflammatory inflammatory corecore

AntiAnti

Homeopathic Homeopathic antalgic coreantalgic core

M d l ti f IL1

AntiAnti--degenerative degenerative

corecore•Bryonia 4X

•Sepia officinalis 4X•Phosphoricum ac. 6X

•Modulation of IL1 αand IL1 β pro-inflammatory activity in the trigger phase of

p•Hamamelis virginiana 6X

•Alumina 8X•Natrum sulphuricum 8X

51inflammation

•Anti-degenerative and anti-neuralgic action

Intervertebral disk, Porcine 4X

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Lumbar + Guna®-Muscle: low back pain due to muscular and tendineous trigger points, low-back pain caused by strain from prolonged stay in erect position, lumbago caused by sports training.

Guna®-Lumbar + Guna®-Ischial: sacroiliac syndrome leg neuritis sciaticGuna -Lumbar + Guna -Ischial: sacroiliac syndrome, leg neuritis, sciatic neuralgia.

Guna®-Lumbar + Guna®-Neural: low back pain, lumbar neuritis with projected pain to the lower thoracic side.

Guna®-Lumbar + Guna®-Polyarthritis: general lumbar arthrosis, sacroiliac syndrome caused by rheumatoid arthritis.syndrome caused by rheumatoid arthritis.

Guna®-Lumbar + Guna®-Arthro: lumbar arthrosis, lumbar articular discomfort.

Guna®-Lumbar + Guna®-Lympho: pre- and post-surgery recovery of a disc

52

Guna Lumbar Guna Lympho: pre and post surgery recovery of a disc hernia L4-L5, L5-S1.

GUNA®-LUMBAR into specificlocal Acupuncture PointsSelected according to the most painful area (max 10 points each

Ex Shiqizhuixia

BL 52

GV 4

BL 23

painful area (max 10 points each treatment)

BL 52

Ex Yaoyan

BL 31BL 32

GV 2BL 23

BL 24

BL 25

BL 26BL 32

BL 53

BL 33

BL 27

BL 28

BL 29

BL 30

Ex Huanzhong

BL 54

BL 30

BL 34

BL 36

GB 30

53

BL 36

BL 35

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

54treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

55© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®® ISCHIALISCHIALGUNAGUNA®®--ISCHIALISCHIALClinical Indications

Sciatica painSciatica painLumbar-sciatic painNerve pain in the lowerNerve pain in the lower

lumbar spine Leg nerve pain due toLeg nerve pain due to

post-surgery treatment of disk herniation L4-L5,of disk herniation L4 L5, L5-S1

Morton neuroma56

Morton neuroma

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Aconitum napellus 8X HPUS Anti interleukin 1 alpha 4C8X HPUS, Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Arsenicum album 6X HPUS Beta Endorphin 4Calbum 6X HPUS, Beta-Endorphin 4C, Cimicifuga racemosa 4X HPUS, Gnaphalium polycephalum 4X HPUSGnaphalium polycephalum 4X HPUS, Lachesis mutus 8X HPUS, Rhododendron chrysanthum 6X HPUS Rhuschrysanthum 6X HPUS, Rhus toxicodendron 4X HPUS 2 parts.

Inactive ingredient: Sterile isotonic sodium chloride solution

57

sodium chloride solution.

© Dipartimento Scientifico Guna S.p.a.

• Anti interleukin 1 alpha 4C GUNA®-ISCHIAL

• Beta-Endorphin 4C • Anti interleunin 1 beta 4C

P.N.E.I. P.N.E.I. AntiAnti--

inflammatoryinflammatory

•• Pain symptomatology Pain symptomatology reduction by means of UPreduction by means of UP--REGULATION of REGULATION of β––Endorphin Endorphin

tt

• Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation

antalgic coreantalgic coreinflammatory inflammatory

corecore

Primary Primary neuralgic painneuralgic pain

receptorsreceptors

•Lachesis mutus 8X

• Modulation of abdominal wall reflexed sciatic pain (Lachesis) Reflexed Reflexed

neuralgicneuralgic neuralgic painneuralgic pain

Secondary Secondary neuralgic painneuralgic pain

•Lachesis mutus 8X •Gnaphalium polycephalum 4X

•Arsenicum album 6X •Rhododendron chrysantum 6X

e e ed sc at c pa ( ac es s)and iliac-sacral lumbar pain (Cimicifuga)

neuralgic neuralgic painpain

Modulation of sciatic pain

•Aconitum napellus 8X

• Cimicifuga 4X

• Lachesis mutus 8X pby means of inflammation neurogen phase inhibition (Aconitum and Arsenicum)and direct action on the sciatic nerve

• Pain modulation by means of a reduction in the progression of osteochondrosis

•Cimicifuga 4X

•Rhus toxicodendron 4X

58

(Gnaphalium)of osteochondrosis (Cimicifuga), coxo-femoral arthrosis(Rhus tox.), backache (Rhus tox). © Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Ischial + Guna®-Lumbar: Sacroiliac syndrome, leg neuritis, sciatic neuralgia.

Guna®-Ischial + Guna®-Neural: Leg neuritis and sciatic neuralgia in hyper acute phasehyper-acute phase.

Guna®-Ischial + Guna®-Flam: decongesting action of the leg nervesGuna®-Ischial + Guna®-Flam: decongesting action of the leg nerves, especially at the level of the vasa nervorum.

59

GUNA®-ISCHIAL into specific and selectedGUNA ISCHIAL into specific and selected

local Acupuncture PointsGB 30GB 30

BL 36

BL 37

BL 40BL 40

BL 39

BL 57

BL 58

60BL 60

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

61treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

62© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--SHOULDERSHOULDERGUNAGUNA®® SHOULDERSHOULDERClinical Indications

S l h l i th itiScapular-humeral peri-arthritis

Shoulder pain

Shoulder-arm syndrome

F h ldFrozen shoulder

Shoulder pain due to dislocation, therapeutic rest

Epicondylitis

63© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Argentum nitricum 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Cartilago suis 4X HPUS, Ferrum phosphoricum 8X HPUS, Sanguinaria canadensis 8X HPUS, Tendon, Porcine 6X 2 parts; Iris versicolor 8X HPUS, Ranunculus bulbosus 10X HPUS 1 part.

Inactive ingredient: Sterile isotonic sodium chloride solution.

64© Dipartimento Scientifico Guna S.p.a.

Reduction of shoulder pain of Reduction of shoulder pain of different origin and type:different origin and type:

• Neuralgic origin (Argentum

GUNA®-SHOULDER• Neuralgic origin (Argentum nitricum, Ferrum phosph., Iris)• Muscular origin (Ranunculus, Sanguinaria)

•Beta-Endorphin 4C

• Pain symptomatology reduction by means of UP-REGULATION of β–Endorphin receptors

( , g )

• Acute pain (Ferrum, Iris)• Chronic pain (Argentum nitricum Ranunculus) P.N.E.I.P.N.E.I. p pnitricum, Ranunculus) P.N.E.I. P.N.E.I.

antalgic coreantalgic core

AntiAnti--HomeopathicHomeopathic

•Anti interleukin 1 alpha 4C

•Anti interleukin 1 beta 4C

inflammatory inflammatory corecore

AntiAnti--

Homeopathic Homeopathic antalgic coreantalgic core

•Argentum nitricum 8X

•Ferrum phosphoricum 8X

M d l ti f IL1

degenerative degenerative corecore

Ferrum phosphoricum 8X

•Iris versicolor 8X

•Sanguinaria canadensis 8X

• Ranunculus bulbosus 10X• Modulation of IL1 αand IL1 β pro-inflammatory activity in the trigger phase of •Cartilago suis 4X

65inflammation

• Anti-degenerative and chronic anti-inflammatory action (Tendon, Porcine)

go su s•Tendon, Porcine 6X

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna® Shoulder + Guna® Polyarthritis: scapulohumeral syndrome caused byGuna®-Shoulder + Guna®-Polyarthritis: scapulohumeral syndrome caused by rheumatoid arthritis or other autoimmune diseases, scapulohumeral periarthritis caused by excessive articular use.

Guna®-Shoulder + Guna®-Muscle: scapulohumeral syndrome by muscle and tendon trigger points of the supraspinatus muscle (80% of the cases), para-scapular muscles and trapezius.

Guna®-Shoulder + Guna®-Neural: epicondylitis, referred pain of the scapulohumeral syndrome along the arm and in the muscle districts nearby.

G ® Sh ld G ® T h ld i d di l iGuna®-Shoulder + Guna®-Trauma: shoulder pain due to dislocation or traumatism.

Guna®-Shoulder + Guna®-Flam: frozen shoulder, scapulohumeral periarthritis in

66

Guna Shoulder Guna Flam: frozen shoulder, scapulohumeral periarthritis in hyper-acute phase.

GUNA®-SHOULDER into specific and selectedGUNA SHOULDER into specific and selected

local Acupuncture PointsShoulderShoulder

LI 16

LI 15 LU 2

Ex Jianneiling

LI 14GB 20

GV 16BL 10

Ex JianquianEx Jianzhong

LI 11

GB 21

LI 16

TE 14

BL 10

GV 14

SI 12TE 14

SI 10

SI 9TE 13

SI 11

67

TE 13LI 14

GUNA®-SHOULDER into Trigger Points

and referred pain zonesTP/TE 14

TP/SI 13TP/SI 12

ShoulderTP

BL 43

SI 11TPD4

TP/SI 10TP/SI 10

TP/SI 9TP/Ex

Jianneiling TP = Main Trigger Points and correlated Acupuncture points

68

Acupuncture points

TP

LU 1TP

D7

BL 467

TP = Main Trigger Points and correlated

69

and correlated Acupuncture points

GUNA®-SHOULDER into specific and selectedGUNA SHOULDER into specific and selected

local Acupuncture PointsElbowElbow

LI 12

LI 11

LI 8LI 10

TE 10

SI 8

SI 7

TE 4

TE 5

Ex Quyahgwei

TE 4

LU 5 HT 3

PC 3

SI 4HT 5HT 4

HT 4

SI 7

70

HT 4

HT 5

SI 8 HT 3

GUNA®-SHOULDER into Trigger Points gg

and referred pain zones

ElbowLU 5

TP

TP

SI 8

TE 9

TP = Main Trigger Points and correlated

71

and correlated Acupuncture points

HT 3

TP Elbow

TP

PC 3

TP

72TP = Main Trigger Points and correlated Acupuncture points

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

73treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

74© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--HANDFOOTHANDFOOTGUNAGUNA HANDFOOTHANDFOOTClinical Indications

O t th iti f di it iOsteoarthritis of digits painRhizoarthrosis of the thumb

(Forestier disease)(Forestier disease)Arthrosis pain due to hammer

toeCarpal-tunnel syndrome De Quervain diseaseM t l d M t t l iMetacarpal and Metatarsal painMorton disease Rheumatoid arthritis ofRheumatoid arthritis of

hand/footHand/Foot tendon pain due to

75prolonged immobilization (tendon pain related to casts)

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Arnica montana 4X HPUS, Viola odorata 6X HPUS 4 parts; , p ;Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin , p4C, Caulophyllum thalictroides 12X HPUS 2 parts; Benzoicum acidum 6X HPUS, p ; ,Cimicifuga racemosa 10X HPUS, Ledum palustre 6X HPUS, Mercurius solubilis 8X p ,HPUS 1 part.

Inactive ingredient: Sterile isotonic sodium chloride solution.

76© Dipartimento Scientifico Guna S.p.a.

• Anti interleukin 1 alpha 4C GUNA®-HANDFOOT

• Beta-Endorphin 4C • Anti interleukin 1 beta 4C

P.N.E.I.P.N.E.I.

antalgic coreantalgic coreAntiAnti--

inflammatoryinflammatory

•• Pain symptomatology Pain symptomatology reduction by means of UPreduction by means of UP--REGULATION of REGULATION of β––Endorphin Endorphin

tt

• Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammationantalgic coreantalgic core inflammatory inflammatory

corecore

Inflammatory Inflammatory

receptorsreceptors

• Pain modulation by means of Gout painGout painpainpain

Degenerative Degenerative painpain

•Arnica montana 4X•Caulophillum thalictroides 12X

uric acid crystals accumulation inhibition (drainage action)

pp

•Ledum palustre 6X

•Benzoicum acidum 6X

Pain modulation by means of acute inflammation phenomena – vasal in particular – inhibition (arthrosis type)P i d l ti b f

•Viola odorata 6X

•Mercurius solubilis 8X

•Cimicifuga racemosa 10X

77

(arthrosis type)• Pain modulation by means of degenerative process (arthrosis type) inhibition

•Cimicifuga racemosa 10X

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Handfoot + Guna®-Polyarthritis: rheumatoid arthritis and other autoimmune diseases of hands and feet.

Guna®-Handfoot + Guna®-Neural: carpal tunnel syndrome, neuritis after plaster cast removal, Morton disease, general pain of hand and foot, neuritis of hand and foot.

Guna®-Handfoot + Guna®-Lympho: carpal tunnel syndrome, post surgery recovery.

Guna®-Handfoot + Guna®-Trauma: before and after surgical operations of hand and foot, sports contusions.

78

GUNA®-HANDFOOT into specific and selectedGUNA HANDFOOT into specific and selected

local Acupuncture PointsSI 5 SI 4

Wrist

LI 5LI 6

PC 6

TE 4

SI 5

LU 9HT 5

PC 7

LI 5 SI 6

TE 5Ex Zhongquan

79HT 7 LI 6

gq

LI 1 TE 1

HT 9SI 1

SIFENG POINTS

HandHT 8

PC 8LU 11

PC 8 BIS

TE 3

TE 2

BAXIE POINTS

Ex Luozhen Hand

PC 7

LU 9HT 7

LI 4

TE 4

TE 3

Ex Zhongquan

PC 6 TE 5LI 2

LI 3LI 4

Zhongquan

BAXIE POINTS

LI 5

BAXIE POINTS

SI 3SI 2

SI 1

80TE 1

SI 5LU 10

SI 4

FootFootST 41

ST 42

GB 40

ST 43GB 41

GB 42

GB 43

ST 44

LR 2

LR 3

GB 43

BAFENG

BL 67

ST 45GB 44 SP 1LR 1

In particularly painful anatomic parts such as hands and foot digits, spray ethyl chloride for 2-3 seconds at a distance of

81about 20 cm before infiltrating

GUNA®-HANDFOOT into specific and selectedGUNA HANDFOOT into specific and selected

local Acupuncture PointsGB 38

GB 39

ST 41 ST 42

Ex Bafeng 3

S FootST 41

ST 43LR 3 ST 44

LR 2

LR 1

BL 59

BL 60

BL 62BL 63

BL 64 GB 42 GB 43GB 44

ST 45

SP 6BL 62 BL 64

GB 41

GB 42

BL 65

GB 43

BL 67

KI 3

GB 40

KI 4

82KI 5SP 5KI 2SP 3

SP 1

SP 2

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

83treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

84© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--HIPHIPClinical Indications

Hip joint osteoarthrosisHip joint osteoarthrosisHip joint capsule

inflammationinflammationHip joint rheumatoid

arthritisarthritis Hip joint pain of muscle

originorigin Hip joint pain of nerve

origin (burning hip)origin (burning hip)Hip joint pain due to

prolonged bed rest85

prolonged bed restKnee osteoarthrosis

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Arnica montana 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Calcarea fluorica 6X HPUS, Cartilago suis 4X HPUS, Colocynthis 8X HPUS, Rhus toxicodendron 10X HPUS 2 parts; Argentum metallicum 6X HPUS, Formicum acidum 8X HPUS 1 part.

Inactive ingredient: Sterile isotonic sodium chloride solution.

86© Dipartimento Scientifico Guna S.p.a.

•Argentum metallicum 6X•Arnica montana 8X

•Colocynthis 8X

GUNA®-HIP

Reduction of hip pain

• Beta-Endorphin 4C

Colocynthis 8X•Formicum ac. 8X

• Rhus toxicodendron 10X

P.N.E.I. P.N.E.I. antalgic coreantalgic core

Homeopathic Homeopathic

•• Pain symptomatology Pain symptomatology reduction by means of UPreduction by means of UP--REGULATION of REGULATION of β––Endorphin Endorphin

tt

Reduction of hip pain symptoms of

rheumatic origin :

• Capsule (Formicum ac Argentum)antalgic coreantalgic core antalgic coreantalgic core

AntiAnti--inflammatoryinflammatoryConstitutionalConstitutional

receptorsreceptors ac., Argentum)• Tendons and ligaments (Rhus tox)• Nerves (Colocynthis)• Constitutional correction of inflammatory inflammatory

corecoreConstitutional Constitutional

corecore

AntiAnti--degenerative degenerative

corecore

• Muscles (Arnica)articular structure pathology

• Anti interleukin 1 alpha 4C

• Anti interleukin 1 beta 4C• Calcarea fluorica 6X

• Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase

• Biostimulation of cartilagineous matrix components synthesis ( il )

• Cartilago suis 4X

• Argentum metallicum 6X

87

of inflammation(Cartilago)

• New vessels development stimulation (Argentum)

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Hip + Guna®-Muscle: satellite muscles involvement in case of pre-arthrosis or hip and knee arthrosis.

Guna®-Hip + Guna®-Neural: inguinal neuritis and neuritis affecting theGuna -Hip + Guna -Neural: inguinal neuritis and neuritis affecting the upper leg, caused by hip arthrosis, burning hip, neuritis due to knee arthrosis.

Guna®-Hip + Guna®-Polyarthritis: coxarthritis due to rheumatoid arthritis and other autoimmune diseases, acute coxarthritis of sportsmen.

Guna® Hip + Guna® Arthro: hip joint osteoarthritis hip joint capsuleGuna®-Hip + Guna®-Arthro: hip joint osteoarthritis, hip joint capsule inflammation.

Guna®-Hip + Guna®-Trauma: before and after surgical operations of the

88

p g phip, pain caused by prosthesis.

GUNA®-HIP into specific and selected local Acupuncture PointsAcupuncture Points

BL 54 GB 29GB 27

GB 28

S 3

SP 12ST 30

LR 12LR 11

BL 54

GB 30GB 29

ST 31

ST 32

LR 10

SP 11

GB 31

Hip

ST 32 GB 31GB 32

BL 40LR 8

BL 40

GB 34SP 9

GB 28SP 12ST 31

GB 27

LR 11

LR 12

ST 30

89

ST 31

LR 10

GUNA®-HIP into Trigger Points and referred pain zones

TP/GB 30

TP/Ex Tunzhong

BL 54

GB 29

GB 30

TP

zones

TP

Hip

TP = Main Trigger Points

TP/GB 33ST 31

TP/GB 33

TP/SP 10

TP

90

KneeKnee

91

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

92treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

93© Dipartimento Scientifico Guna S.p.a.

94

GUNAGUNA®®--POLYARTHRITISPOLYARTHRITISGUNAGUNA®® POLYARTHRITISPOLYARTHRITISClinical Indications

Small joints rheumatoid arthritis of hand and foot

Costo-sternal syndrome (Tietze syndrome)

h i l h i i dChronic polyarthritis due to auto-immune diseases (e.g. Lupus erythematosus sistemicus)erythematosus sistemicus)

Broken bone syndrome due to viral or protozoic diseasep

Joint pain due to cancer disease (chronic leukemia, monoclonal blood di )

95diseases)

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Salicylicum acidum 2X HPUS 4 parts; Aconitum napellus 6X HPUS, Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C,

d hiBeta-Endorphin 4C, Drosera 8X HPUS, Ledum palustre 8X HPUS, Viscum

lb l hialbum 10X HPUS 2 parts; Colchicum autumnale 10X HPUS, Guaiacum 10X

SHPUS 1 part.

I i i di S il i iInactive ingredient: Sterile isotonic sodium chloride solution.

96© Dipartimento Scientifico Guna S.p.a.

GUNA®-POLYARTHRITIS

• Reduction of polyarticular pain symptomatology in acute inflammation having different

•Beta-Endorphin 4C

• Pain symptomatology reduction by means of UP-REGULATION of β–Endorphin receptors

inflammation having different localization

P.N.E.I. P.N.E.I. p pantalgic coreantalgic core

AntiAnti--Acute Acute •Salycilicum acidum 2X

•Anti interleukin 1 alpha 4C

•Anti interleukin 1 beta 4C

inflammatory inflammatory corecore

inflammatory inflammatory painpain

y

•Aconitum 6X

•Drosera 8X

•Colchicum autumnale 10X

M d l ti f IL1

Chronic Chronic inflammatory paininflammatory pain

•Guaiacum 10X

• Modulation of IL1 αand IL1 β pro-inflammatory activity in the trigger phase of

• Reduction of degenerative articular pain •Ledum palustre 8X

97inflammation

dege e a e a cu a paon a chronic-evolutive basis

•Viscum album 10X

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Polyarthritis + Guna®-Handfoot: rheumatoid arthritis or other autoimmune diseases of the small joints of hand and foot, metatarsalgia, metacarpalgia.

Guna®-Polyarthritis + Guna®-Neural: costosternal syndrome, in cases of presence of satellite neuritis in rheumatoid arthritis or other autoimmune diseasesdiseases.

Guna®-Polyarthritis + Guna®-Muscle: in cases of prevalence of muscle pain in rheumatoid arthritis or other autoimmune diseasesin rheumatoid arthritis or other autoimmune diseases.

Guna®-Polyarthritis + Guna®-Arthro: rheumatoid arthritis, localized or systemic arthrosis arthritis in single or several areas

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systemic arthrosis, arthritis in single or several areas.

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

99treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

100© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--MUSCLEMUSCLEGUNAGUNA®® MUSCLEMUSCLEClinical Indications

Trigger points management: gg p gacute, subacute, chronic

Fibromyalgia syndrome

Referred somatic pain area managementg

Dermatomyositis101

y

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Arnica montana 4X HPUS Colocynthis 4X HPUS 4 parts;HPUS, Colocynthis 4X HPUS 4 parts; Belladonna 6X HPUS, Lithium benzoicum 8X HPUS Muscle tissue Porcine 4C8X HPUS, Muscle tissue, Porcine 4C, Procaine chloride 2X 2 parts; Colchicum autumnale 6X HPUS Cuprum sulphuricumautumnale 6X HPUS, Cuprum sulphuricum 4X HPUS, Hypericum perforatum 4X HPUS, Interferon gamma 4C 1 partInterferon gamma 4C 1 part.

Inactive ingredient: Sterile isotonicInactive ingredient: Sterile isotonic sodium chloride solution.

102© Dipartimento Scientifico Guna S.p.a.

GUNA®-MUSCLE•Interferon γ 4C

P i hl id 2X

•Arnica montana 4X

•Belladonna 6X

Contusive Contusive

•Procain chloride 2X

•Muscle tissue, Porcine 4CAnti-

degenerativepainpain

Spastic or Spastic or crampcramp--likelike

Muscular Muscular

degenerative core

crampcramp--like like painpain

Sprain Sprain painpain

C l hi 4X

• Colchicum autumnale 6X

•Lithium benzoicum 8X

rheumatism rheumatism

•Colocynthis 4X•Cuprum sulphuricum 4X

•Hypericum 4X

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Hypericum 4X

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Muscle + Guna®-Neural: mostly combined for the specific action of muscle relaxation + nerve repolarization, fibromyalgia syndrome, muscle pain due to the nerve entrapment.

Guna®-Muscle + Guna®-Neck: all muscle pain due to cervical syndromes.

Guna®-Muscle + Guna®-Thoracic: all muscle pain due to thoracic syndromes.

Guna®-Muscle + Guna®-Lumbar: all muscle pain due to low-back syndromes.

Guna®-Muscle + Guna®-Hip: all muscle pain due to hip or knee syndromes.

Guna®-Muscle + Guna®-Shoulder: all muscle pain due to shoulder or elbow syndrome.

G ® M l G ® Fl ll l h104

Guna®-Muscle + Guna®-Flam: all muscle aches.

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

105treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

106© Dipartimento Scientifico Guna S.p.a.

GUNAGUNA®®--NEURALNEURALClinical Indications

Non-specific brachial painNon specific brachial painBrachial nerve pain due to cervical

entrapment Intercostal nerve pain due to thoracic

entrapmentPostherpetic neuritisPostherpetic neuritisAtypical facial neuritis (Slüder

syndrome, Charlin syndrome)syndrome, Charlin syndrome)Trigeminal neuritisPain of the temporomandibular joint

(TMJ)Arnold syndrome Cervical thoracic lumbar and

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Cervical, thoracic, lumbar and sacrolumbar nerve root pain

© Dipartimento Scientifico Guna S.p.a.

Active ingredients: Aconitum napellus 8X HPUS, Beta-Endorphin 4C, Colocynthis 4X HPUS, Ferrum phosphoricum 2X HPUS, Formica rufa 8X HPUS, Gnaphalium polycephalum 6X HPUS, Iris versicolor 8X HPUS, Kalmia latifolia 2X HPUS, Neurotrophin 4 4C, Paris quadrifolia 6X HPUS 2 parts.

Inactive ingredient: Sterile isotonic sodium chloride solution.

108© Dipartimento Scientifico Guna S.p.a.

•Kalmia latifolia 2X

•Ferrum phosphoricum 2XGUNA®-NEURAL

• Beta-Endorphin 4C •Colocynthis 4X

•Paris quadrifolia 6X

•Gnaphalium polycephalum 6X

P.N.E.I. P.N.E.I. antalgic antalgic InflammatoryInflammatory

•• Pain symptomatology Pain symptomatology reduction by means of UPreduction by means of UP--REGULATION of REGULATION of β––Endorphin Endorphin

tt

•Iris versicolor 8X

•Aconitum napellus 8X

corecoreInflammatory Inflammatory

aetiologyaetiology

Vascular Vascular

receptorsreceptors

• Reduction of different peripheral nerves inflammationRheumatoid Rheumatoid

aetiologyaetiology

Degenerative Degenerative aetiologyaetiology

inflammation• Modulation of paresis and paralysis phenomena

aetiologyaetiology

•Formica rufa 8X

• Kalmia latifolia 2X

Reduction of pain and paraesthetic phenomena by means of hyperemetic

• Trophic action on roots and nerve endings damaged

•Neurotrophin 4 4C

109

y ypaction on nerves

e e e d gs da agedbecause of degenerative or lesionary phenomena

© Dipartimento Scientifico Guna S.p.a.

Infiltration points for trigeminal paintrigeminal pain

Infiltration points for Charlin andCharlin and Slüdersyndromes

110pain

© Dipartimento Scientifico Guna S.p.a.

Most common combinations:

Guna®-Neural + Guna®-Muscle: mostly combined for the specific action onGuna -Neural + Guna -Muscle: mostly combined for the specific action on nerve repolarization + muscle relaxation, fibromyalgia syndrome, muscle pain due to the nerve entrapment.

G ® N l + G ® N k ll l i d t i l dGuna®-Neural + Guna®-Neck: all neural pain due to cervical syndromes.

Guna®-Neural + Guna®-Thoracic: all neural pain due to thoracic syndromes.

Guna®-Neural + Guna®-Lumbar: all neural pain due to low-back syndromesGuna®-Neural + Guna®-Lumbar: all neural pain due to low-back syndromes.

Guna®-Neural + Guna®-Hip: all neural pain due to hip or knee syndromes.

Guna®-Neural + Guna®-Shoulder: all neural pain due to shoulder or elbowGuna Neural Guna Shoulder: all neural pain due to shoulder or elbow syndromes.

Guna®-Neural + Guna®-Ischial: neuritis of the leg and sciatic neuralgia in hyperacute phase

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hyperacute phase.

Guna®-Neural + Guna®-Flam: all nerve aches.

TreatmentTreatment

Standard protocol for i.m. administration:1 ampoule 1-3 times a week according to severity and clinical evolution.

Standard protocol according to h i h i i 1 2mesotherapeutic technique using 1-2

ampoules per treatment: 2 treatments for the fi 2 k 1 k ill i li ffirst 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). F h i th l i ti 1 t t tFor chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 t t t th

112treatment a month.

© Dipartimento Scientifico Guna S.p.a.

Type of needle

Select application site according to acupuncture points, trigger points, tender p p gg ppoints, referred pain zones, nerve key points, Head zones or “local pain points”. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

113© Dipartimento Scientifico Guna S.p.a.

THANK YOU VERYTHANK YOU VERYTHANK YOU VERY THANK YOU VERY MUCH FOR YOURMUCH FOR YOURMUCH FOR YOUR MUCH FOR YOUR KIND PRESENCE KIND PRESENCE AND ATTENTION …AND ATTENTION …

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