energy def: the capacity to do work 2 kinds –kinetic energy of motion –potential stored energy
TRANSCRIPT
Energy
• Def: the capacity to do work
• 2 kinds– Kinetic
• Energy of motion
– Potential • Stored energy
• all an organisms chemical reactions• Break down complex molecules into simpler
molecules, and building complex molecules from simpler ones
In order for any reaction to occur, bonds have to be broken.
This takes ENERGYACTIVATION ENERGY energy required to get a reaction started
Good Animation
Enzymes
• Show specificity (each enzyme can catalyze one / VERY few reactions)
• Are reusable (shape is unchanged)
• Lower activation energy thus speeding up the reaction rate
• Are proteins
• Destroy shape=destroy function (for all proteins)– Called denaturation
Condition
Trial 1 Trial 2 Trial 3 Average
toothpicks only
toothpicks+ nails
toothpicks and tape
Your hand was why?
Toothpick was why?
Nail was why?
Tape was why?
Inhibitors
• Competitive– Is similar to the substrate and can fit into the
active site, but no reaction occurs. Blocks the substrate from entering
• Noncompetitive– Binds to the enzyme at a place that IS NOT
THE ACTIVE SITE but changes the shape of the active site, now there’s no fit between active site and substrate
Cofactors
• Something required by enzyme in order to function– Can be inorganic (iron, zinc… remember the
trace elements?)– Can be organic (coenzyme)
• Vitamins are coenzymes
IonExamples of enzymes containing
this ion
Cupric Cytochrome oxidase
Ferrous or Ferric
CatalaseCytochrome(via Heme)
NitrogenaseHydrogenase
MagnesiumGlucose 6-phosphatase
Hexokinase
Manganese Arginase
Molybdenum Nitrate reductase
Nickel Urease
Selenium Glutathione peroxidase
ZincAlcohol dehydrogenase
Carbonic anhydraseDNA polymerase
Cofactor Vitamin Additional componentChemical group(s) transferred
Thiamine diphosphate [24]
Thiamine (B1) None2-carbon groups, α cleavage
NAD+ and NADP+ [25] Niacin (B3) ADP Electrons
Pyridoxal phosphate [26] Pyridoxine (B6) NoneAmino and carboxyl groups
Methylcobalamin [27] Vitamin B12 Methyl group acyl groups
Biotin [28] Biotin (H) None CO2
Coenzyme A [29] Pantothenic acid (B5) ADPAcetyl group and other acyl groups
Tetrahydrofolic acid [30] Folic acid (B9) Glutamate residuesMethyl, formyl, methylene and formimino groups
Ascorbic acid [32] Vitamin C None Electrons
Flavin mononucleotide [33]
Riboflavin (B2) None Electrons
Flavin adenine dinucleotide [33]
Riboflavin (B2) None Electrons
Coenzyme F420 [34] Riboflavin (B2) Amino acids Electrons
Vitamins and derivatives