endovascular and minimally invasive treatment of varicose...
TRANSCRIPT
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Endovascular and Endovascular and Minimally Invasive Minimally Invasive Treatment of Varicose Treatment of Varicose VeinsVeins
Michael Michael SchmidlingSchmidling, MD, MD
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Common Myths Surrounding Common Myths Surrounding Venous DiseaseVenous Disease
PatientsPatients……
““Something I will have to learn to live Something I will have to learn to live withwith…”…”““They are only of cosmetic concernThey are only of cosmetic concern…”…”““There is nothing I can do about themThere is nothing I can do about them…”…”““I donI don’’t want to undergo surgeryt want to undergo surgery…”…”
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Common Myths Surrounding Common Myths Surrounding Venous DiseaseVenous Disease
PhysiciansPhysicians……
““I donI don’’t treat themt treat them…”…”““Just elevate your legsJust elevate your legs…”…”““DonDon’’t treat these veinst treat these veins……you will need you will need them later for bypass graftingthem later for bypass grafting…”…”
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RealityReality……
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SignificanceSignificance
Improved awareness in both the medical Improved awareness in both the medical community and the lay populationcommunity and the lay populationThere is now a better understanding of the There is now a better understanding of the implications and impact of venous reflux implications and impact of venous reflux diseasediseaseSignificant health impactsSignificant health impactsPatients seek out Patients seek out ““minimally invasiveminimally invasive””procedures and procedures and ““nonnon--surgical therapiessurgical therapies””
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SignificanceSignificance
Your patients will be Your patients will be asking you!asking you!
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Spectrum of DiseaseSpectrum of Disease
Spider veins and Spider veins and telangiectasiastelangiectasias
Small reddish and purple veins near the Small reddish and purple veins near the skin surface (treatment usually consideredskin surface (treatment usually consideredcosmetic and not reimbursed by insurance)cosmetic and not reimbursed by insurance)
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Spectrum of DiseaseSpectrum of Disease
Reticular veinsReticular veins
Blue or green deeper veins under the Blue or green deeper veins under the skin surface (treatment usually consideredskin surface (treatment usually consideredcosmetic and not reimbursed by insurance)cosmetic and not reimbursed by insurance)
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Spectrum of DiseaseSpectrum of Disease
Varicose veinsVaricose veins
Large bulging veins that are easily palpableLarge bulging veins that are easily palpable(usually symptomatic and treatment most (usually symptomatic and treatment most often covered by insurance)often covered by insurance)
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Spectrum of DiseaseSpectrum of Disease
Venous ulcersVenous ulcers
Breakdown of the skin related toBreakdown of the skin related toFailure of the venous system and Failure of the venous system and Venous insufficiency (usually Venous insufficiency (usually symptomatic and treatment mostsymptomatic and treatment mostoften covered by insurance)often covered by insurance)
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PrevalencePrevalence
Coon WW et al. Venous Coon WW et al. Venous ThromboembolismThromboembolism and Other Venous Disease in the Tecumseh Community Health and Other Venous Disease in the Tecumseh Community Health Study. Circulation 1973; 48:839Study. Circulation 1973; 48:839--846. 846.
0
10
20
30
40
50
60
70
80
20-29 40-49 60-69
Women
Men
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Etiology of Varicose VeinsEtiology of Varicose Veins
HeredityHeredityNo known specific genetic factorsNo known specific genetic factorsReflux at Reflux at saphenofemoralsaphenofemoral junction is 2X as junction is 2X as likely in those with a parent with the likely in those with a parent with the conditioncondition
OccupationalOccupationalThose with jobs requiring long periods of Those with jobs requiring long periods of standingstanding
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Etiology of Varicose VeinsEtiology of Varicose Veins
Sex and hormonesSex and hormonesDuring menstrual cycle veins become more During menstrual cycle veins become more distensible due to hormonal influencedistensible due to hormonal influencePregnancyPregnancy
AgeAgeElastic lamina degenerates and smooth Elastic lamina degenerates and smooth muscle layer atrophiesmuscle layer atrophies
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Clinical PresentationClinical PresentationLeg heaviness and achingLeg heaviness and achingExercise intoleranceExercise intolerance““RestlessRestless”” legslegsNight crampsNight crampsEdemaEdemaParesthesiasParesthesiasPain or tenderness along the course of a veinPain or tenderness along the course of a veinSkin changesSkin changes
Edema and Edema and hyperpigmentationhyperpigmentationStasis dermatitisStasis dermatitisulcerationulceration
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Clinical PresentationClinical Presentation
Symptoms generally are least in the Symptoms generally are least in the morning and worsen throughout the morning and worsen throughout the daydayExacerbated by long periods of standingExacerbated by long periods of standingOften history of self medication with Often history of self medication with OTC analgesics and support stockingsOTC analgesics and support stockingsVeins often worsen during pregnancyVeins often worsen during pregnancyProgressive worseningProgressive worsening
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Clinical Presentation Clinical Presentation –– Clinical Clinical CEAP Classification CEAP Classification
ClassClass0 0 –– no signs or symptomsno signs or symptoms1 1 –– spider or reticular veinsspider or reticular veins2 2 –– varicose veinsvaricose veins3 3 –– edemaedema4 4 –– skin changesskin changes5 5 –– healed ulcerhealed ulcer6 6 –– active ulceractive ulcer
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
Unlike upper extremity veins, the veins Unlike upper extremity veins, the veins of the lower extremities are subjected of the lower extremities are subjected to significant hydrostatic pressureto significant hydrostatic pressureNormal valves help Normal valves help ““segmentsegment”” this this column of blood to reduce the pressure column of blood to reduce the pressure felt by any segment of the veinfelt by any segment of the veinVenous system is a Venous system is a low low pressure pressure systemsystem
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
Deep and a superficial system Deep and a superficial system separated by the deep muscular fasciaseparated by the deep muscular fasciaDeep system is relatively high pressure Deep system is relatively high pressure due to the due to the ““calf pumpcalf pump”” mechanism to mechanism to facilitate venous return to the heartfacilitate venous return to the heartThe superficial system is a lower The superficial system is a lower pressure, capacitance systempressure, capacitance system
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
Deep SystemDeep SystemCFVCFVFemoral veinFemoral veinPoplitealPopliteal veinveinCalf veins Calf veins –– tibialtibial and and gastrocnemiusgastrocnemius
Superficial SystemSuperficial SystemGSVGSVLSVLSVTributariesTributaries
PerforatorsPerforators
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
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Normal Anatomy and PhysiologyNormal Anatomy and Physiology
Calf PumpCalf PumpCalf muscles contract and due to the tight, rigid Calf muscles contract and due to the tight, rigid muscular fascia results in elevated pressure to muscular fascia results in elevated pressure to ““pumppump”” the blood against gravity and towards the the blood against gravity and towards the heartheartWhen the muscles relax, pressure decreases and When the muscles relax, pressure decreases and allows flow from the superficial to deep system via allows flow from the superficial to deep system via perforatorsperforatorsCompetent valves in the perforators and Competent valves in the perforators and superficial system prevent exposure of the superficial system prevent exposure of the superficial system to the higher pressures of the superficial system to the higher pressures of the deep systemdeep system
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Etiology of Venous InsufficiencyEtiology of Venous Insufficiency
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Superficial Venous InsufficiencySuperficial Venous InsufficiencyEtiology of Primary DiseaseEtiology of Primary Disease
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Superficial Venous InsufficiencySuperficial Venous Insufficiency
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Superficial Venous InsufficiencySuperficial Venous Insufficiency
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Superficial Venous InsufficiencySuperficial Venous Insufficiency
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Superficial Venous InsufficiencySuperficial Venous Insufficiency
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Superficial Venous InsufficiencySuperficial Venous Insufficiency
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Superficial Venous InsufficiencySuperficial Venous Insufficiency
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Common Patterns of RefluxCommon Patterns of Reflux
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Great Saphenous Vein RefluxGreat Saphenous Vein RefluxTreatment GoalsTreatment Goals
Eliminate refluxEliminate refluxSFJ and SPJSFJ and SPJPerforator(s)Perforator(s)
Ablate incompetent Ablate incompetent venous segmentsvenous segmentsEliminate Eliminate recirculationrecirculationClinical improvementClinical improvement
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Surgical Ligation and StrippingSurgical Ligation and Stripping
Traditional therapyTraditional therapyPossible complications of surgeryPossible complications of surgery
Paresthesia, infection, bleeding, scarsParesthesia, infection, bleeding, scarsProlonged recovery periodProlonged recovery periodIncreased costs of inIncreased costs of in--hospital procedurehospital procedureGreater risks and costs associated with Greater risks and costs associated with general anesthesiageneral anesthesia
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Endovascular Varicose Vein RxEndovascular Varicose Vein Rx
Therapy of varicose veins has been Therapy of varicose veins has been revolutionized by endovascular revolutionized by endovascular techniques such as techniques such as endovenousendovenous
laser therapy.laser therapy.
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Endovascular Varicose Vein RxEndovascular Varicose Vein Rx
Endovascular ablation of Greater Endovascular ablation of Greater SaphenousSaphenousVein using laser or radiofrequency energy Vein using laser or radiofrequency energy transmitted through a catheter based systemtransmitted through a catheter based systemAncillary procedures: sclerotherapy and Ancillary procedures: sclerotherapy and ambulatory phlebectomyambulatory phlebectomyResults comparable to (and often better than) Results comparable to (and often better than) ligationligation and stripping with decreased and stripping with decreased morbidity and shorter post procedure morbidity and shorter post procedure recovery timerecovery time
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Endovascular Varicose Vein RxEndovascular Varicose Vein Rx
Basic Basic tenenttenent: Underlying venous : Underlying venous insufficiency and insufficiency and valvularvalvular incompetence incompetence must be treated first. must be treated first. ““AncillaryAncillary”” procedures such as procedures such as phlebectomy and sclerotherapy are phlebectomy and sclerotherapy are doomed to failure if there is persistent doomed to failure if there is persistent underlying reflux. underlying reflux.
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Endovascular Varicose Vein RxEndovascular Varicose Vein RxThe search for less invasive techniques to treat varicose The search for less invasive techniques to treat varicose veins has led to the development ofveins has led to the development of
Ultrasound Guided SclerotherapyUltrasound Guided Sclerotherapy(liquid and foam)(liquid and foam)
Endovenous Laser TreatmentEndovenous Laser Treatment
Diomed 810 nm Diode Laser
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Endovenous Laser TreatmentEndovenous Laser TreatmentMaterials and MethodsMaterials and Methods
Venous mapping with duplexVenous mapping with duplex--ultrasoundultrasound5 Fr introducer sheath placed into GSV5 Fr introducer sheath placed into GSV600 600 micron lasermicron laser fiber (Diomed, Inc., fiber (Diomed, Inc., Andover, MA) introduced into sheathAndover, MA) introduced into sheathLaser fiber positioned at SFJ using US and Laser fiber positioned at SFJ using US and direct visualization of red aiming beamdirect visualization of red aiming beam0.2% lidocaine delivered perivenously under 0.2% lidocaine delivered perivenously under sonographic guidance (distal to proximal)sonographic guidance (distal to proximal)
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Endovenous Laser TreatmentEndovenous Laser TreatmentMaterials and MethodsMaterials and Methods
810 nm wavelength laser energy provided by 810 nm wavelength laser energy provided by Diomed Laser (Diomed, Inc., Andover, MA)Diomed Laser (Diomed, Inc., Andover, MA)Laser energy delivered endovenously 10 mm Laser energy delivered endovenously 10 mm below SFJ and along GSVbelow SFJ and along GSVFiber withdrawn at rate of 1Fiber withdrawn at rate of 1--3 mm per 3 mm per second second 14 watts continuous mode14 watts continuous modeClass I (20Class I (20--30 mm Hg) stockings for 4 wks30 mm Hg) stockings for 4 wks
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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The ProcedureThe Procedure
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The ProcedureThe Procedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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PostPost--procedureprocedure
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Ancillary ProceduresAncillary Procedures
PhlebectomyPhlebectomyAfter surgical prep, skin is anesthetized After surgical prep, skin is anesthetized with dilute with dilute lidocainelidocaine solutionsolutionSmall Small ““stabstab”” incisions are made with 16g incisions are made with 16g admixture needleadmixture needleVaricosities are hooked with a phlebectomy Varicosities are hooked with a phlebectomy hookhookHemostats used to pull and Hemostats used to pull and ““teasetease”” the the vein outvein outRepeated over course of varicosityRepeated over course of varicosity
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Ancillary ProceduresAncillary Procedures
Phlebectomy hooksPhlebectomy hooks
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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ProcedureProcedure
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Ancillary ProceduresAncillary Procedures
SclerotherapySclerotherapyInjection of a Injection of a sclerosantsclerosant agent that agent that chemically chemically ““burnsburns”” the endothelium of vein the endothelium of vein causing occlusioncausing occlusionPolidocanolPolidocanol, STS, hypertonic saline, etc., STS, hypertonic saline, etc.VariationsVariations
US guidedUS guided““foamfoam””
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Ancillary ProceduresAncillary Procedures
SclerotherapySclerotherapy
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Pre-Treatment 1 Wk Post-EVLT
GreaterGreater Saphenous VeinSaphenous Vein
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Greater Greater SaphenousSaphenous VeinVein
Pre-Treatment 1 Wk Post-EVLT
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Greater Greater SaphenousSaphenous VeinVein
Pre-Treatment 2 Wks Post-EVLT
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Greater Greater SaphenousSaphenous VeinVein
Pre-Treatment Post-Treatment
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Greater Greater SaphenousSaphenous VeinVein
Pre-Treatment Post-Treatment
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Posterior Medial TributaryPosterior Medial Tributary
Pre-Treatment 4 Wks Post-EVLT
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Pre-Treatment Post-Treatment
Lesser Saphenous VeinLesser Saphenous Vein
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Endovenous Laser Treatment Endovenous Laser Treatment –– Results: Cornell VascularResults: Cornell Vascular
• 701 limbs treated in 610 subjects• 595 (85%) presented with aching pain
701 Total Limbs
566
65
70
GSV
SSV
ALT
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Endovenous Laser Treatment Endovenous Laser Treatment –– Results: Cornell VascularResults: Cornell Vascular
mean: 43 yrsmean: 43 yrsrange: 22 range: 22 -- 76 yrs76 yrs
98 (16%) men98 (16%) men512 (84%) women512 (84%) womenGender
Age
mean: 38 cmmean: 38 cmrange: 9 range: 9 -- 70 cm70 cm
mean: 10 mmmean: 10 mmrange: 4.1 range: 4.1 -- 35 mm35 mm
330 (47%) right330 (47%) right371 (53%) left371 (53%) leftSide
Diameter
Length
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Endovenous Laser Treatment Endovenous Laser Treatment --ResultsResults
94 %94 %99 %99 %100 %100 %100 %100 %
218 / 231218 / 231245 / 247245 / 247151 / 151151 / 15172 / 7272 / 72
< 1 Year< 1 Year1 1 –– 2 Years2 Years2 2 –– 3 Years3 Years> 3 Years> 3 Years
Continued OcclusionContinued OcclusionClosed / No. TreatedClosed / No. TreatedFollowFollow--Up (Yrs)Up (Yrs)
• Followed 3 – 42 months (mean of 20 months)
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Endovenous Laser Treatment Endovenous Laser Treatment --ResultsResults
98% (686/701) closed at 3 98% (686/701) closed at 3 -- 42 42 monthsmonths223 limbs followed at least 2 years 223 limbs followed at least 2 years demonstrate continued occlusiondemonstrate continued occlusion
Min R, Khilnani N, Zimmet. Endovenous laser treatment of saphenous vein reflux: long-term results. JVIR 2003; 14: 991-996.
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Endovenous Laser Treatment Endovenous Laser Treatment --ResultsResults
> 99% with resolution of symptoms> 99% with resolution of symptoms> 99 % would recommend EVLT> 99 % would recommend EVLTBruising & mild / moderate tenderness Bruising & mild / moderate tenderness (resolving in < 2 wks)(resolving in < 2 wks)
NONO skin burns, DVTs, or paresthesiasskin burns, DVTs, or paresthesias
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Endovenous Laser Treatment Endovenous Laser Treatment --ConclusionsConclusions
Successful ablation of > 97% of limbs treated Successful ablation of > 97% of limbs treated with endovenous laserwith endovenous laserContinued closure of more than 220 vein Continued closure of more than 220 vein segments followed for > 2 yearssegments followed for > 2 yearsResults comparable or superior to other Results comparable or superior to other options available for treatment of GSV refluxoptions available for treatment of GSV refluxEVLT offers these benefits with lower rates of EVLT offers these benefits with lower rates of complication and avoidance of general complication and avoidance of general anesthesiaanesthesia
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The Vein Center at Atlantic The Vein Center at Atlantic Medical ImagingMedical Imaging
Michael Michael SchmidlingSchmidling, MD, MD Rajesh Patel, MDRajesh Patel, MD
Board certified radiologist with fellowship training in Board certified radiologist with fellowship training in Interventional Radiology Interventional Radiology Certificate of Added Qualification in Vascular and Certificate of Added Qualification in Vascular and Interventional Interventional RadilogyRadilogyCoCo--Directors of Vein CenterDirectors of Vein Center
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The Vein Center at Atlantic The Vein Center at Atlantic Medical ImagingMedical Imaging
All patients are evaluated at our Vein Center in All patients are evaluated at our Vein Center in Galloway.Galloway.Complete consultation including H&P and duplex US Complete consultation including H&P and duplex US performed.performed.Entire spectrum of venous disease from spider veins Entire spectrum of venous disease from spider veins to venous ulceration is treated.to venous ulceration is treated.All procedures and follow up appointments at the All procedures and follow up appointments at the Vein Center in Galloway.Vein Center in Galloway.Procedures are done as an outpatient with light oral Procedures are done as an outpatient with light oral sedation and local anesthetic.sedation and local anesthetic.Minimal recovery time is needed.Minimal recovery time is needed.
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Bottom lineBottom line
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ThanksThanks
Robert J. Min, M.D., Cornell VascularRobert J. Min, M.D., Cornell Vascular--WeillWeill Medical College of Cornell Medical College of Cornell UniversityUniversity