ENDOPLASMIC RETICULUM FUNCTIONS in physiology and pathology

Cordeliers Research Centre, Paris, France

Invited speakers Fabienne Foufelle Thierry Galli Claudio Hetz Stephen High Vivek Malhotra Serge ManiéStefan MarciniakMaurizio MolinariJennifer Rieusset Afshin Samali

OrganizersEric ChevetLaurent CombettesFabienne Foufelle

Keynote speakers Pr. Kazutoshi MoriPr. Peter Walter

October 2-3,2017

ITMO  Biologie  cellulaire,  Développement  et  Evolution    

Endoplasmic Reticulum functions in physiology and pathology Cordeliers Research Centre, Paris, France - October 2-3, 2017

Program : October 2nd, 2017 9 :30 AM – 10 :00 AM Meeting opening/registration

Welcome address by Pascal Ferré, director of Cordeliers Research Centre

10:00 AM – 11 :00 AM Keynote lecture : Peter Walter, USCF, USA, The unfolded protein response and beyond

11 :00 AM – 11 :15 AM Coffee break

11 :15 AM -12 :30 AM Session 1 : ER folding and QC (Chair : Eric Chevet)

• 11 :15 – 11 :45 AM Stephen High, Manchester, UK, Dealing with failure: what happens when membrane proteins get lost? • 11 :45 – 12 :15 AM Maurizio Molinari, EPFL, Suisse, Clearance of protein aggregates from the endoplasmic reticulum • 12 :15 – 12 :30 AM Caroline Demangel, Inst. Pasteur, Paris, Mycolactone prevents immune cell signaling and communication, by targeting the Sec61 translocon

12 :30 AM – 1 :30 PM Lunch break

1 :30 PM - 3 :00 AM Session 2 : Secretory Pathway (Chair : Fabienne Foufelle)

• 1 :30 – 2 :00 PM Vivek Malhotra, CRG, USA, From TANGO1 to a potential cure for fibrosis: the collagen connection

• 2 :00 – 2 :30 PM Stefan Marciniak, CIMR, UK, Measuring ER viscosity: relevance to alpha 1-antitrypsin deficiency

• 2 :30 – 2 :45 PM Delphine Fessart, Université V Segalen, Bordeaux, France, AGR2, an endoplasmic reticulum protein, in cancer: multifaceted functions and potential clinical implications

sponsored by the International Center for Cancer Vaccine Science (ICCVS) • 2 :45 – 3 :00 PM Catherine Jackson, IJM, Paris, Regulation of ER-Golgi transport and

beyond: the multiple roles of GBF1

3 :00 PM - 4 :15 PM Session 3 : Interorganelle communication (Chair : Laurent Combettes)

• 3 :00 – 3 :30 PM Thierry Galli, CPN, Paris, Role of non-fusogenic SNAREs at ER-plasma membrane contact sites in neurite outgrowth

• 3 :30 – 4 :00 PM Jennifer Rieusset, Université Lyon, France, Metabolic signaling functions of endoplamic reticulum-mitochondria contact sites: role in metabolic diseases

• 4 :00 – 4 :15 PM Benjamin Delprat, INM, Montpellier, France, ER-Mitochondria crosstalk is regulated by NCS1 and is impaired in Wolfram syndrome sponsored by the Wolfran syndrome association

1

ITMO  Biologie  cellulaire,  Développement  et  Evolution    

Endoplasmic Reticulum functions in physiology and pathology Cordeliers Research Centre, Paris, France - October 2-3, 2017

2

Program : October 2nd, 2017

9:00 AM – 10 :00 AM Keynote lecture : Kazutoshi Mori, Kyoto University, Japan, The unfolded protein response : to mammals and beyond

10 :00 AM -11 :45 AM Session 4 : Disease 1 (Chairs : Eric Ogier Denis & Eric Chevet)

• 10 :00 – 10 :30 AM Claudio Hetz, University of Chile, Santiago, Proteostasis imbalance and neurodegenerative diseases • 10 :30 – 11 :00 AM Fabienne Foufelle, CRC, Paris, Endoplasmic reticulum proteostasis in Non Alcoholic Fatty Liver diseases

11 :00 AM – 11 :15 PM Coffee break

• 11 :15 -11 :30 AM Béatrice Bailly-Maitre, Nice, France, Targeting IRE1α protects from Non Alcoholic Steatohepatitis in Bl-1 deficient mice

sponsored by the American Journal of Physiology • 11 :30 – 11 :45 AM Morgan Gallazzini, INEM, Paris, Lipocalin 2 mediates

Endoplasmic reticulum stress deleterious effect in proteinuric nephropathies

11 :45 AM - 12 :45 AM Session 5 : Disease 2

• 11 :45 – 12 :15 AM Serge Manié, CRCL, Lyon, France, Sustained Hexosamine pathway upon low glucose maintains EGFR signaling in lung tumors

• 12 :15 – 12 :45 AM Afshin Samali, NIU Galway, Ireland, IRE1-XBP1 as a therapeutic target in breast cancer

12 :45 AM – 2 :30 PM Lunch break

2 :30 PM – 3 :30 PM Discussion about the creation of an international organization focusing on ER biology

***********************************************************************************************************************************

4 :15 PM – 6 :00 PM Speed dating session

October 3rd 2017

Speakers and organizers 2017 Conference “Endoplasmic Reticulum Functions in Physiology and Pathology”

Keynote Speakers Peter WALTER (San Francisco)

Dept of Biochemistry & Biophysics, MC2200, 600 16th St, N316, San Francisco, CA 94143 peter@walterlab.ucsf.edu http://walterlab.ucsf.edu/

Kazutoshi MORI (Kyoto, Japan)

Kitashirakawa-Oiwake, Sakyo-ku, Kyoto, Japan, mori@upr.biophys.kyoto-u.ac.jp http://www.upr.biophys.kyoto-u.ac.jp/en/

Speakers Béatrice BAILLY-MAITRE (Nice, France)

C3M –Inserm U1065 Beatrice.BAILLY-MAITRE@unice.fr http://www.unice.fr/c3m/index.php/research-teams/

Benjamin DELPRAT (Montpellier, France)

Institut for Neurosciences Montpellier Hôpital Saint Eloi - Bâtiment INM 80, rue Augustin Fliche - BP 74103 34091 Montpellier cedex 5 - France benjamin.delprat@inserm.fr http://www.inmfrance.com/inm/en

Caroline DEMANGEL (Paris, France)

Institut Pasteur U1221 caroline.demangel@pasteur.fr https://research.pasteur.fr/fr/member/caroline-demangel/

Delphine FESSART (Bordeaux, France)

Université Victor Segalen Bordeaux · Centre de Recherche Cardio-Thoracique de Bordeaux

delphine.fessart@yahoo.fr https://crctb.u-bordeaux.fr/Le-CRCTB

   

Morgan GALLAZZINI (Paris, France)

UMR8253 Institut Necker Enfants Malades - Centre de médecine moléculaire (INEM) morgan.gallazzini@inserm.fr https://ecolesdoctorales.parisdescartes.fr/ed157/Equipes-de-recherche/Liste-des-equipes-d-accueil/Mecanismes-et-strategies-therapeutiques-des-maladies-renales-chroniques

Thierry GALLI (Paris, France)

Membrane Traffic in Health & Disease Group (INSERM ERL U950), F-75013 Paris, France thierry.galli@inserm.fr https://cpn.paris5.inserm.fr/recherche/equipes-et-projets/15-team-galli

Claudio HETZ (Santiago, Chile)

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile chetz@med.uchile.cl http://ecb-icbm.med.uchile.cl/index.php

Stephen HIGH (Manchester, UK)

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, U.K stephen.high@manchester.ac.uk http://www.chstm.manchester.ac.uk/people/profile/?PersonID=802

Cathy JACKSON (Paris, France)

Institut Jacques Monod - UMR 7592 CNRS - Université Paris Diderot-Paris7 Bat. Buffon – 1er étage - P. 144B 15, rue Hélène Brion cathy.jackson@ijm.fr http://www.ijm.fr/en/research/research-groups/membrane-dynamics/

Vivek MALHOTRA (Barcelona, Spain)

Centre for Genomic Regulation (CRG), C/ Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain vivek.malhotra@crg.eu http://www.crg.eu/en/vivek_malhotra

Serge MANIE (Lyon, France)

INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. serge.manie@lyon.unicancer.fr http://www.crcl.fr/566-Serge-Manie-group.crcl.aspx?language=en-GB

Stefan MARCINIAK (Cambridge, UK)

Department of Medicine, University of Cambridge, Cambridge, United Kingdom. sjm20@cam.ac.uk https://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-i-p/marciniak

Maurizio MOLINARI (Lugano, Suisse)

Università della Svizzera italiana, CH-6900 Lugano, Switzerland. maurizio.molinari@irb.usi.ch http://www.irb.usi.ch/maurizio-molinari

Jennifer RIEUSSET (Lyon, France)

INSERM UMR-1060, CarMeN Laboratory, Lyon 1 University, INRA U1397, F-69921 Oullins, France JENNIFER.RIEUSSET@univ-lyon1.fr https://www.crnh-rhone-alpes.fr/fr/liste-des-membres/rieusset-jennifer

Afshin SAMALI (Galway, Ireland)

Apoptosis Research Centre, National University of Ireland Galway, Galway, Ireland School of Natural Sciences, National University of Ireland Galway, Galway, Ireland afshin.samali@nuigalway.ie http://www.nuigalway.ie/our-research/people/natural-sciences/afshinsamali/

     

 ORGANISATEURS

Eric CHEVET (Rennes, France)

INSERM U1242 COSS laboratory Centre Eugène Marquis Avenue de la Bataille Flandres-Dunkerque, 35000 Rennes eric.chevet1@gmail.com http://oss-clcc-rennes.com/

Laurent COMBETTES (Orsay, France)

UMR 1174 - Interactions cellulaires et physiopathologie hépatiqueUniversité Paris-Sud Bâtiment 443 Rue des Adèles 91405 Orsay Cedex

laurent.combettes@u-psud.fr

Fabienne FOUFELLE (Paris, France) & Speaker

INSERM UMRS 1138, Sorbonne Universités, UPMC Université Paris 06; Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot; and Centre de Recherche des Cordeliers, Paris, France fabienne.foufelle@crc.jussieu.fr http://www.crc.jussieu.fr/fabienne_foufelle_equipe.html

   

Patrizia AGOSTINIS patrizia.agostinis@kuleuven.be

Daniel AJOY MORENO dajoym@gmail.com

Noemie ALPHONSE ludivine.baron@pasteur.fr

Muhammad ASLAM muhammad.aslam@med.uni-giessen.de

Tony AVRIL t.avril@rennes.unicancer.fr

Anna BABOUR anna.babour@inserm.fr

Béatrice BAILLY-MAITRE Beatrice.BAILLY-MAITRE@unice.fr

Naziha BAKOUH naziha.bakouh@inserm.fr

Hélène BARELLI barelli@ipmc.cnrs.fr

Ludivine BARON ludivine.baron@pasteur.fr

Lucillia BEZU lucilliabe@gmail.com

DHIRAJ BHATIA dhiraj.bhatia@curie.fr

Sara BITAM sarabitam@gmail.com

Tirosh BOAZ Boazt@ekmd.huji.ac.il

Regis BOBE regis.bobe@inserm.fr

Emilie BONCOEUR emilie.boncoeur@univ-paris13.fr

Joseph BOSSOWSKI jpbossowski@unice.fr

Heloïse BOURIEN heloise.bourien@gmail.com

Céline BRUGE cbruge@istem.fr

Agnès BRUN agnes.brun@etu.unistra.fr

Andrea BURGO andrea.burgo@univ-evry.fr

Anne-Françoise BURNOL anne-francoise.burnol@inserm.fr

Afifaa BUTT afifaabutt@gmail.com

Axelle CADORET axelle.cadoret@inserm.fr

Henri CAO henri.cao@orange.fr

Aristotelis CHATZILOANNOU achatzi@e-nios.com

Cédric CHAVEROUX cedric.chaveroux@lyon.unicancer.fr

Eric CHEVET eric.chevet1@gmail.com

Chetan CHINTHA chetan.chintha@nuigalway.ie

Kevin COLON kevin.colon@ucsf.edu

Laurent COMBETTES laurent.combettes@u-psud.fr

Alenka COPIC alenka.copic@ijm.fr

Quentin DEFENOUILLERE quentin.defenouillere@gmail.com

Elaine DEL NERY edel@curie.fr

Agnes DELAUNAY-MOISAN agnes.delaunay-moisan@cea.fr

Benjamin DELPRAT benjamin.delprat@inserm.fr

Caroline DEMANGEL caroline.demangel@pasteur.fr

Nicolas DEMAUREX Nicolas.Demaurex@unige.ch

Sara Filipa DIAS HENRIQUES shenriques@genethon.fr

Dimitrios DOULTSINOS dimitrios.doultsinos@inserm.fr

Geneviève DUPONT gdupont@ulb.ac.be

Catharina DUVIGNEAU catharina.duvigneau@vetmeduni.ac.at

Aleksander EDELMAN aleksander.edelman@inserm.fr

Khalid EL HACHIMI khalid.el_hachimi@upmc.fr

Vincent ELGHOUZZI vincent.elghouzzi@inserm.fr

Leif ERIKSSON leif.eriksson@chem.gu.se

Marion ESPELI marion.espeli@u-psud.fr

Philippe FERNANDES PH.FERNANDES@gustaveroussy.fr

Carole FERRARO-PEYRET carole.ferraro-peyret@univ-lyon1.fr

Ana FERREIRO ana.b.ferreiro@gmail.com

Delphine FESSART delphine.fessart@yahoo.fr

Fabienne FOUFELLE fabienne.foufelle@crc.jussieu.fr

Morgan GALLAZZINI morgan.gallazzini@inserm.fr

Thierry GALLI thierry.galli@inserm.fr

Laure GARRIGUE-ANTAR laure.garrigue-antar@u-pec.fr

Manuel GIMENEZ ANDRES manuel.gimenezandres@ijm.fr

Francesca GIORDANO francesca.giordano@i2bc.paris-saclay.fr

Edyta GLOGOWSKA glogowska.ee@gmail.com

Laurence GUYONNEAU-HARMAND laurence.harmand@upmc.fr

Jonathan HARNOSS harnossj@gene.com

Sandra HEALY sandra.healy@nuigalway.ie

Ramanath HEGDE ramanath.hegde@epfl.ch

Claudio HETZ chetz@med.uchile.cl

Stephen HIGH stephen.high@manchester.ac.uk

Alexandre HINZPETER alexandre.hinzpeter@inserm.fr

Eric HONORE Honore@ipmc.cnrs.fr

Aeid IGBARIA aeid.igbaria@ucsf.edu

Cathy JACKSON cathy.jackson@ijm.fr

Gwénaële JEGOU g.duval@rennes.unicancer.fr

Haixiu JIN haixiu.jin@ens-lyon.fr

Andrey KOZLOV andrey.kozlov@trauma.lbg.ac.at

Kamel LAGHMANI kamel.laghmani@crc.jussieu.fr

Gwenaelle LE PAVEC gwenaelle.le-pavec@cea.fr

Pierre-Jean LE RESTE pierre-jean.le.reste@chu-rennes.fr

Christine LE ROY christine.le-roy@inserm.fr

Cynthia LEBEAUPIN Cynthia.Lebeaupin@unice.fr

Christophe LEFEBVRE christophe.lefebvre@i2bc.paris-saclay.fr

Gilles LEMAITRE glemaitre@istem.fr

Christine LEMAITRE christine.lemaitre@inserm.fr

Emilie LEMESRE emilie.lemesre@inserm.fr

Sebastien LEON Sebastien.leon@ijm.fr

Alice LEON alice.leon10@gmail.com

Alain LESCURE a.lescure@ibmc-cnrs.unistra.fr

Brian LEUZZI brian.leuzzi@gmail.com

Susan LOGUE Susan.logue@nuigalway.ie

Morgane LOUESSARD louessard.m@istem.fr

Andreia LUIS andreiavluis@gmail.com

Gergely LUKACS gergely.lukacs@mcgill.ca

Olga LUZINA olg.luzina@gmail.com

Mohamed MAHAMEED mohamed.mahameed2@mail.huji.ac.il

Nasire MAHMUDI nasire.mahmudi@sanofi.com

Vivek MALHOTRA vivek.malhotra@crg.eu

Serge MANIE serge.manie@lyon.unicancer.fr

Olivier MANSIER olivier.mansier@gmail.com

Bruni MANZ b.manz@wanadoo.fr

Stefan MARCINIAK sjm20@cam.ac.uk

Vincent MARION vincent.marion@unistra.fr

Jean-Alain MARTIGNOLES jamartignoles@hotmail.com

Laura MATABISHI-BIBI mbibilaura@gmail.com

Nicole MCCARTHY nicolemccarthy1@gmail.com

Mari MCMAHON mariclaremcmahonrcs@hotmail.com

Vera MEDVEDEVA vera.medvedeva@ijm.fr

Oleksandr MINCHENKO ominchenko@yahoo.com

Maurizio MOLINARI maurizio.molinari@irb.usi.ch

Matthieu MONCAN matthieu.moncan@institutimagine.org

Luigi MONTIBELLIER l.montibellier@imperial.ac.uk

Mohammad Amin MOOSAVI a-moosavi@nigeb.ac.ir

Sanket MORE sanket.more@kuleuven.be

Jean-David MOREL jean-david.morel@pasteur.fr

Kazutoshi MORI mori@upr.biophys.kyoto-u.ac.jp

Maryline MOULIN maryline.moulin@univ-paris-diderot.fr

Valeria NAIM valeria.naim@gustaveroussy.fr

Anne-Sophie NICOT nicotan@univ-grenoble-alpes.fr

Xavier NISSAN xnissan@istem.fr

Nerymar Ortiz NO no79@cornell.edu

Cahir O'KANE c.okane@gen.cam.ac.uk

Joanna OBACZ joanna.obacz87@gmail.com

Akram OBIEDAT obiedat.ak@gmail.com

Eric OGIER-DENIS eric.ogier-denis@inserm.fr

Megan OLIVA mo412@cam.ac.uk

Marion ONNEE marion.onnee@gmail.com

Luis OSORIO luisosorior88@gmail.com

Nicolas PALLET nicolas.pallet@parisdescartes.fr

Ganna PANASYUK ganna.panasyuk@inserm.fr

Alexandra PAPAIOANNOU papaioannouale@gmail.com

Bela PAPP belapapp2@yahoo.fr

Emilie PELLIER emilie.pellier@ijm.fr

Fabiana PEROCCHI perocchi@genzentrum.lmu.de

Virginie PICARD vpicard.asw@orange.fr

Pascal PIGNY pascal.pigny@inserm.fr

Eleftherios PILATIS epilalis@e-nios.com

Raphaël PINEAU raphael.pineau.1@univ-rennes1.fr

Olivier PLUQUET olivier.pluquet@ibl.cnrs.fr

Iwona PRANKE iwona.pranke@inserm.fr

Mireille PRAT me.prat@laposte.net

Alexandre PROLA alexandre.prola@gmail.com

Franziska PÜESCHEL fpueschel@idibell.cat

Marveh RAHMATI m_rahmati@tums.ac.ir

Oksana RATUSHNA oksana_ratushna@hotmail.com

Jennifer RIEUSSET JENNIFER.RIEUSSET@univ-lyon1.fr

Sylvie ROBINE sylvie.robine@inserm.fr

Leila ROCHIN leila.rochin@i2bc.paris-saclay.fr

Kevin ROUAULT-PIERRE kevinrouaultpierre@gmail.com

Benoit ROUSSEL broussel@cyceron.fr

Camila RUBIO-PATINO crubiopatino@unice.fr

Fahri SAATCIOGLU fahris@ibv.uio.no

Naima Mishal SALMAN naimamishal@live.com

Ashin SAMALI afshin.samali@nuigalway.ie

Marie-Eisabeth SAMSON-BOUMA marie-elisabeth.samson-bouma@inserm.fr

Mabel SAN ROMAN mabel.san-roman@curie.fr

Maria Livia SASSANO marialivia.sassano@kuleuven.be

Béatrice SATIAT-JEUNEMAITRE bsj@i2bc.paris-saclay.fr

Vincent SCARCELLI vincent.scarcelli@i2bc.paris-saclay.fr

Quentin SCHENKELAARS quentin.schenkelaars@unige.ch

Marianne SEDRU marianne.sedru@ens-lyon.fr

Isabelle SERMET-GAUDELUS isabelle.sermet@aphp.fr

Jorgen SIKKELAND jorgen.sikkeland@ibc.uio.no

Axelle SIMON axelle.simon@inserm.fr

Munawar Hussain SOOMRO munawar.soomro@iplesp.upmc.fr

Athanasia STOUPA athanasia.stoupa@inserm.fr

Charoensin SUPHACHAI suphachai.ch@up.ac.th

Quentin TAVERNIER quentin.tave@gmail.com

David THOMAS david.thomas@mcgill.ca

Michel TOLEDANO michel.toledano@cea.fr

Valerie URBACH valerie.urbach@inserm.fr

Déborah VALLEE deborah.vallee@unice.fr

Cécile VOISSET cecile.voisset@univ-brest.fr

Laurence WALCH laurence.walch@ijm.fr

Peter WALTER peter@walterlab.ucsf.edu

Hiderou YOSHIDA hide@sci.u-hyogo.ac.jp

 

   Notes

Bd  St  M

ICHE

L  

Métro    ODEON