endometrial cancer in foods', herbs' and vitamins' points of view

8/12/2019 Endometrial Cancer in Foods', Herbs' and Vitamins' Points of View

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Endometrial Cancer in Foods', Herbs' and Vitamins'

Points of ViewBy Kyle J. Norton

The incidence of endometrial cancer among white women are higher incomparison to black. According to the statistic, the risk of endometrial

cancer among women is 1 in 7000. Every year, about 0,000 women in !"

are diagnosed with the disease. #omen who carry certain mutation genes,

such as $%&A1 or the $%&A' are associated to increased risk of

endometrial cancer.

(epending to the stage and grade of the cancer, chemotherapy such as

(o)orubicin, &isplatin. *aclita)el, &arboplatin, Topotecan may be

necessary after surgery with certain side effects. Although epidemiological

studies focusing the effective of vegetables and fruits in reduced risk and

treatment of endometrial cancer with inconclusive results+1+'+-+, certainfoods, through clinical studies have been found effectively in reduced risk

and treatment of endometrial cancer with little or no side effects.

Endometrium is the inner lining of the mammalian uterus and very

susceptible hormone change, particular to menstrual cycle. Endometrial

cancer is a late adulthood cancer defined as a condition in which the cells of

the endometrial lining of uterus have growth uncontrollably or become

cancerous as a result of the alternation of cells (A. /ts the fourth most

common cancer among women overall, after breast cancer, lung cancer, and

bowel cancer.

Te !enes m"tation

#. B$C%# or te B$C%& !ene

#omen who carry the genes $%&A1 or the $%&A', according to amilial

$reast &ancer %esearch study are associated to risk of endometrial cancer,

specialty for the gene $%&A, but the e)cessive risk is largely attributable to

a history of Tamo)ifen use.+1 and in aged group between 2 to 70+'.

&. "tations in (N% mismatc re)air *$+ !enes

3utations in (A mismatch repair +33% genes affects the (A repairprowess, elevating endometrial cancer risk, due to the loss of proofreading

activity of *ol4 +-. The !niversity of 5)ford study, indicated that mutation

of germline e)onuclease domain ++E(3s of *56E and *56(1 are

associated to predispose to endometrial cancer +E& risk+, 5ther study

showed that defection in either (A proofreading or 33% may relate

to genomic instability and tumourigenesis+2.


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. Pos)atase and tensin omolo! *PTEN+

3ation of 3utations of this gene are associated to the development of many

types of cancer, specially in altered gene in estrogendependent

endometrioid endometrial carcinoma tumors+8

-. K-ras m"tations

9ras gene are protein product plays an essential function in normal tissue

signaling. 3utation of 9%A" gene is associated to the development of

many cancers. According to the study by :aukel and !niversity :ospital,

9%A" mutations over amplification and e)pression were presented in 1.7;

of primary lesions with no increase in metastatic lesions but in 1


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Taking altogether, genetic mutation of certain genes is associated with

increased risk of endometrial cancer. ortunately, certain foods and herbs

have found to be effective in suppressing the e)pression and blocking the

preoperative mechanism and pathways. *lease note that all articles written

by 9yle D. orton are for information education only, please consult your

(octor %elated field specialist before applying.

$eferences

+1 The incidence of endometrial cancer in women with $%&A1 and

$%&A' mutationsF an international prospective cohort study by "egev G,

/Hbal D, 6ubinski D, Ironwald D, 6ynch :T, 3oller *, Ihadirian *, %osen $,

Tung , 9im"ing &, oulkes #(, euhausen "6, "enter 6, "inger &,

9arlan $, *ing ", arod "AC :ereditary $reast &ancer "tudy Iroup.

+*ub3ed+' The risk of endometrial cancer in women with $%&A1 and $%&A'

mutations. A prospective study by $einer 3E, inch A, %osen $, 6ubinski

D, 3oller *, Ihadirian *, 6ynch :T, riedman E, "un *, arod "AC

:ereditary 5varian &ancer &linical "tudy Iroup+*ub3ed

+- A common cancerassociated (A polymerase JvarepsilonK mutation

causes an e)ceptionally strong mutator phenotype, indicating fidelity defects

distinct from loss of proofreading by 9ane (*, "hcherbakova *L+*ub3ed

+ M/dentification and management of :*&& syndrome +hereditary non

polyposis colon cancer, hereditary predisposition to colorectal and

endometrial adenocarcinomasN.

MArticle in rench by 5lschwang ", $onaOti &, eingold D, rPbourg T,

IrandQouan ", 6asset &, 6aurent*uig *, 6ecuru , 3illat $, "obol :,

Thomas I, Eisinger .+*ub3ed

+2 (A polymerase 4 and R e)onuclease domain mutations in endometrial

cancer by &hurch (, $riggs "E, *alles &, (omingo E, 9earsey "D, Irimes

D3, Iorman 3, 3artin 6, :owarth 93, :odgson "LC "E&I

&ollaborators, 9aur 9, Taylor D, Tomlinson /*+*ub3ed

+8 Ienetics of Endometrial &ancers by Tsuyoshi 5kuda,1,S

Akihiko"eki>awa,1Guditiya *urwosunu,1, '3asaaki agatsuka,13iki 3orioka,1

3asaki :ayashi,1and Takashi 5kai+*ub3ed

+7 9%A" gene amplification and overe)pression but not mutation

associates with aggressive and metastatic endometrial cancer by $irkeland

E, #ik E, 3Qs ", :oivik EA, Trovik D, #erner :3, 9usonmano 9,

*etersen 9, %aeder 3$, :olst , Uyan A3, 9alland 9:, Akslen 6A,
http://www.ncbi.nlm.nih.gov/pubmed/23562522http://www.ncbi.nlm.nih.gov/pubmed/16962648http://www.ncbi.nlm.nih.gov/pubmed/24525744http://www.ncbi.nlm.nih.gov/pubmed/15242312http://www.ncbi.nlm.nih.gov/pubmed/23528559http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852605/http://www.ncbi.nlm.nih.gov/pubmed/23562522http://www.ncbi.nlm.nih.gov/pubmed/16962648http://www.ncbi.nlm.nih.gov/pubmed/24525744http://www.ncbi.nlm.nih.gov/pubmed/15242312http://www.ncbi.nlm.nih.gov/pubmed/23528559http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852605/


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"imon %, 9rakstad &, "alvesen :$.+*ub3ed

+o G, /noue :, "aegusa 3+*ub3ed

+10 3utation of betacatenin gene in endometrial cancer but not in

associated hyperplasia by Ashihara 9, "aito T, 3i>umoto :, ishimura 3,

Tanaka %, 9udo %.+*ub3ed

+11 uclear locali>ation of betacatenin in normal and carcinogenic

endometrium by ei :, "aito T, Gamasaki :, 3i>umoto :, /to E, 9udo %.

+*ub3ed

+1' %isks of colorectal and other cancers after endometrial cancer for

women with 6ynch syndrome by #in A9, 6indor 3, #inship /, Tucker93, $uchanan ((, Goung D*, %osty &, 6eggett $, Iiles II, Ioldblatt D,

3acrae A, *arry ", 9alady 3, $aron DA, Ahnen (D, 3archand 66,

Iallinger ", :aile %#, ewcomb *A, :opper D6, Denkins 3A+*ub3ed

+1- *revalence of 6ynch syndrome among patients with newly diagnosed

endometrial cancers by Egoavil &, Alenda &, &astilleQo A, *aya A, *eiro I,

"Vnche>:eras A$, &astilleQo 3/, %oQas E, $arberV L3, &igWen>a ", 6ope>

DA, *iXero 5, %omVn 3D, 3artYne>Escori>a D&, Iuarinos &, *ere>

&arbonell 6, Aranda /, "oto D6.+*ub3ed

+1 *rospective evaluation of molecular screening for 6ynch syndrome in

patients with endometrial cancer B 70 years by 6eenen &:, van 6ier 3I,

van (oorn :&, van 6eerdam 3E, 9ooi "I, de #aard D, :oedemaeker %,

van den 5uweland A3, :ulspas "3, (ubbink :D, 9uipers ED, #agner A,

(inQens #, "teyerberg E#.+*ub3ed

+12 "tructural, molecular and cellular functions of 3":' and 3":8 during

(A mismatch repair, damage signaling and other noncanonical activities

3ichael A. Edelbrocka,, "aravanan 9aliyaperumalb, , 9andace D.

#illiams+"cience direct

3. Endometrial Cancer in Foods Points of View#. Cr"cifero"s 4e!etables

&ruciferous vegetables are the group of vegetables belonging to the family

$rassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

The vegetables have been suggested to reduced risk and protect against

various types of cancer+2. /ndole-carbinol +/-&, a chemical constituent

found in cruciferous vegetables, in (onryu rats study showed to be effective
http://www.ncbi.nlm.nih.gov/pubmed/23099803http://www.ncbi.nlm.nih.gov/pubmed/24182564http://www.ncbi.nlm.nih.gov/pubmed/12111402http://www.ncbi.nlm.nih.gov/pubmed/10411147http://www.ncbi.nlm.nih.gov/pubmed/23385444http://www.ncbi.nlm.nih.gov/pubmed/24244552http://www.ncbi.nlm.nih.gov/pubmed/22306203http://www.sciencedirect.com/science/article/pii/S0027510713000134http://www.ncbi.nlm.nih.gov/pubmed/23099803http://www.ncbi.nlm.nih.gov/pubmed/24182564http://www.ncbi.nlm.nih.gov/pubmed/12111402http://www.ncbi.nlm.nih.gov/pubmed/10411147http://www.ncbi.nlm.nih.gov/pubmed/23385444http://www.ncbi.nlm.nih.gov/pubmed/24244552http://www.ncbi.nlm.nih.gov/pubmed/22306203http://www.sciencedirect.com/science/article/pii/S0027510713000134


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in inhibition of spontaneous occurrence of endometrial adenocarcinoma as

well as preneoplastic lesions+8. "ince

metabolic profile of estrogens may be crucial for the endometrial

carcinogenesis, /ndole-carbinol +/-& e)erted its antiestrogen and

induced apoptotic effects through the ' and hydro)ylation pathways

+catechol estrogens and the downstream of the 18betahydro)ylation

pathway+7.

&. 5arlic

Iarlic is a natural superfood healer for its natural antibiotic with antiviral,

antifungal, anticoagulant and antiseptic properties. Allium vegetables have

been found in many studies to have an inverse association between the

freHuency of use of and the risk of several common cancers+


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7oybean is genus Ilycine, the family abaceae, one of the legumes that

contains twice as much protein per acre as any other maQor vegetable or

grain crop, native to "outheast Asia. ow, it is grown worldwide with

suitable climate for commercial profit and a healthy foods.

*hytochemicals such as daid>ein, genistein, or glycitein found in soy and

other legumes have been speculated to reduce the risk of endometrial cancer

and specially in lean women+18.. According to the !niversity of :awaii

&ancer &enter, greater consumption of isoflavonecontaining foods is

associated with a reduced risk of endometrial cancer in nonhysterectomi>ed

postmenopausal women+17. /n Estrogeninduced proliferation of

endometrial epithelial cells, genistein found in legime and organic

soy inhibited the proliferative effects of estrogen on endometrial

adenocarcinoma cells presumably through activation of stromal cell

E%?+1


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world. The !niversity of $ristol study showed that there is some positive

evidence for risk reduction of endometrial cancers with green tea

consumption+'. +Epigallocatechin-gallate +EI&I, a maQor

polyphenol in green tea, inhibited endometrial cancer cell line through

inhibiting E%9 activation and inducing apoptosis via %5" generation and

p-< activation+'2. The populationbased casecontrol study in urban

"hanghai indicated that the reduction of risk of endometrial cancer may be

only limit to premenopausal women+'8. "ome studies suggested that tea

consumption may reduce the risk of endometrial cancer but further

prospective studies are needed+'7.

9. Coffee

&offee made from the roasted seeds of the genus &offee, belonging to the

family %ubiaceae native to southern Arabia. "trong evidence suggested

that drinking coffee reduced risk of endometrial cancer and there is acorrelation of caffeinated coffee intake associated with lower endometrial

cancer risk among obese postmenopausal women+'7 but the association

with decaffeinated coffee remains unclear. /n a prospective cohort study,

conducted by the :arvard "chool of *ublic :ealth, $oston, indicated that

(rinking of coffee, may reduce endometrial cancer risk, but addition of

substantial sugar and cream to coffee could offset any potential benefits+'


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;. 6li4e oil

5live is belongs to the the family 5leaceae, native to the coastal areas of the

eastern 3editerranean $asin and south end of the &aspian "ea. /ts fruit, is

also called the olive and the source of olive oil.

According to the study by the !niversity of Athens 3edical "chool,

increased intake of monounsaturated fat, mostly olive oil, was associated

with endometrial cancer risk reduction and increased olive oil intake by 1

standard deviation, reduced risk of endometrial cancer by '8; +-. /n a


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+7 Effects of estrogens and metabolites on endometrial carcinogenesis in

young adult mice initiated with ethylnitronitrosoguanidine by

Takahashi 3, "himomoto T, 3iyaQima 9, Goshida 3, 9atashima ",

!ematsu , 3aekawa A, akae (.+*ub3ed

+


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thickness, hyperplasia, and endometrial cancer risk in postmenopausal

womenF a randomi>ed controlled trial by ]uaas A31, 9ono , 3ack #D,

:odis :, eli) D&, *aulson %D, "houpe (.+*ub3ed

+'0 #hole grain, dietary fiber, and incidence of endometrial cancer in a

(anish cohort study by Aarestrup D1, 9yr &, &hristensen D, 9ristensen 3,

#Wrt> A3, Dohnsen , 5vervad 9, TQnneland A, 5lsen A+*ub3ed

+'1 6ignans and human health by Adlercreut> :.+*ub3ed

+'' #hole grain intake and incident endometrial cancerF the /owa #omens

:ealth "tudy by 9asum &31, icodemus 9, :arnack 6D, Dacobs (% Dr,

olsom A%C /owa #omens :ealth "tudy+*ub3ed

+'- #hole grain intake and cancerF a review of the literature by Dacobs (%

Dr1, "lavin D, 3arHuart 6+*ub3ed

+' Ireen tea and green tea catechin e)tractsF an overview of the clinical

evidence by Dohnson %1, $ryant ", :untley A6+*ub3ed

+'2 +Epigallocatechin-gallate induces apoptosis in human endometrialadenocarcinoma cells via %5" generation and p-< 3A* kinase activation

by 3anohar 31, atima /, "a)ena %, &handra L, "ankhwar *6, (wivedi

A+*ub3ed

+'8 MIreen tea consumption and the risk of endometrial cancerF a

populationbased casecontrol study in urban "hanghaiN.MArticle in &hineseN

by Iao D1, ^iang G$, ^u #:, "hao &^, %uan \^, &heng D%, "hu ^5, Iao

GT+*ub3ed

+'8 Tea consumption and risk of endometrial cancerF a metaanalysis by

Tang *1, 6i :, ]iu G6, \hou I3, 3a D+*ub3ed

+'7 &affeinated coffee, decaffeinated coffee and endometrial cancer riskF a

prospective cohort study among !" postmenopausal women by Iiri A1,

"turgeon "%, 6uisi , $ertoneDohnson E, $alasubramanian %, %eeves

9#+*ub3ed

+'oros &", #olk A+*ub3ed

+-0 atty fish consumption lowers the risk of endometrial cancerF anationwide casecontrol study in "weden by Terry *1, #olk A, Lainio :,

#eiderpass E+*ub3ed

+-1 Associations of longchain Z- fatty acids and fish intake with

endometrial cancer risk in the L/Tamins And 6ifestyle cohort by $rasky

T31,euhouser 36, &ohn (E, #hite E+*ub3ed

+-' ood intake and the risk of endometrial endometrioid adenocarcinoma
http://www.ncbi.nlm.nih.gov/pubmed/23422867http://www.ncbi.nlm.nih.gov/pubmed/23163844http://www.ncbi.nlm.nih.gov/pubmed/17943494http://www.ncbi.nlm.nih.gov/pubmed/11759278http://www.ncbi.nlm.nih.gov/pubmed/8610041http://www.ncbi.nlm.nih.gov/pubmed/22986087http://www.ncbi.nlm.nih.gov/pubmed?term=Manohar%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Fatima%20I%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Saxena%20R%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Chandra%20V%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Sankhwar%20PL%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Dwivedi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Dwivedi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed/22959059http://www.ncbi.nlm.nih.gov/pubmed/16053753http://www.ncbi.nlm.nih.gov/pubmed/19766982http://www.ncbi.nlm.nih.gov/pubmed/22254087http://www.ncbi.nlm.nih.gov/pubmed/22109346http://www.ncbi.nlm.nih.gov/pubmed/19585497http://www.ncbi.nlm.nih.gov/pubmed/11815413http://www.ncbi.nlm.nih.gov/pubmed?term=Brasky%20TM%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=Brasky%20TM%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=Neuhouser%20ML%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=Cohn%20DE%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=White%20E%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed/24500149http://www.ncbi.nlm.nih.gov/pubmed/23422867http://www.ncbi.nlm.nih.gov/pubmed/23163844http://www.ncbi.nlm.nih.gov/pubmed/17943494http://www.ncbi.nlm.nih.gov/pubmed/11759278http://www.ncbi.nlm.nih.gov/pubmed/8610041http://www.ncbi.nlm.nih.gov/pubmed/22986087http://www.ncbi.nlm.nih.gov/pubmed?term=Manohar%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Fatima%20I%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Saxena%20R%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Chandra%20V%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Sankhwar%20PL%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Dwivedi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed?term=Dwivedi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22959059http://www.ncbi.nlm.nih.gov/pubmed/22959059http://www.ncbi.nlm.nih.gov/pubmed/16053753http://www.ncbi.nlm.nih.gov/pubmed/19766982http://www.ncbi.nlm.nih.gov/pubmed/22254087http://www.ncbi.nlm.nih.gov/pubmed/22109346http://www.ncbi.nlm.nih.gov/pubmed/19585497http://www.ncbi.nlm.nih.gov/pubmed/11815413http://www.ncbi.nlm.nih.gov/pubmed?term=Brasky%20TM%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=Brasky%20TM%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=Neuhouser%20ML%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=Cohn%20DE%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed?term=White%20E%5BAuthor%5D&cauthor=true&cauthor_uid=24500149http://www.ncbi.nlm.nih.gov/pubmed/24500149


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in Dapanese women by Takayama "1, 3onma G, Tsubota!tsugi 3, agase

", Tsubono G, umata T, Toyoshima 3, !tsunomiya :, "ugawara D,

Gaegashi +*ub3ed

+-- A prospective investigation of fish, meat and cookingrelated

carcinogens with endometrial cancer incidence by Arem :1, Iunter 3D,

&ross AD, :ollenbeck A%, "inha %+*ub3ed

+- (ietary factors and the risk of endometrial cancerF a casecontrol study

in Ireece by T>onou A1, 6ipworth 6, 9alandidi A, Trichopoulou A,

Iamatsi /, :sieh &&, otara L, Trichopoulos (+*ub3ed

+-2 (iet in relation to endometrial cancer riskF a casecontrol study in

Ireece by *etridou E1, 9edikoglou ", 9oukoulomatis *, (essypris ,

Trichopoulos (+*ub3ed

+-8 &ancer and 3editerranean dietary traditions by Trichopoulou A1,

6agiou *, 9uper :, Trichopoulos (.+*ub3ed

33. Endoemtrial Cancer in Herbs' Points of View

#. 2icorice

2icorice *5lycyrria, belonging to the family abaceae, native to the 3editerranean

and certain areas of Asia. The herb has been used in traditional medicine to

treat skin diseases, coughs, constipation, bronchitis, inflammation, arthritis,

etc. /n mice study, licorice showed to inhibited the proliferation of

endometrial carcinogenesis, through a significant decrease in the &5^', /6

1alpha and Talpha m%A e)pressions+2. 5n estrogenrelated

endometrial carcinogenesis in mice, treatment after ' weeks, licorice

inhibited the E'related endometrial carcinogenesis, through suppression of

estrogeninduced cfos=Qun+a variety of physiological functions including

cell proliferation and differentiatione)pressions+8.

&. 5reen tea

Ireen tea contains more amount of antio)idants than any drinks or food with

the same volume, and is the leaves of &amellia sinensis, undergone minimal

o)idation during processing, originated from &hina. Ireen tea has been a

precious drink in traditional &hinese culture and used e)ceptional insociali>ation for more than 000 years. $ecause of their health benefits, they

have been cultivated for commercial purposes all over the world.

&atechins. the maQor polyphenols in green tea, showed to reduce risk of

endometrial cancer+7. Epigallocatechin-gallate, Another biological active

component of green tea, also

inhibited endometrial cancer cell line +/shikawa cells proliferation, through
http://www.ncbi.nlm.nih.gov/pubmed/24053697http://www.ncbi.nlm.nih.gov/pubmed/23695021http://www.ncbi.nlm.nih.gov/pubmed/8630294http://www.ncbi.nlm.nih.gov/pubmed/12672637http://www.ncbi.nlm.nih.gov/pubmed/11008902http://www.ncbi.nlm.nih.gov/pubmed/24053697http://www.ncbi.nlm.nih.gov/pubmed/23695021http://www.ncbi.nlm.nih.gov/pubmed/8630294http://www.ncbi.nlm.nih.gov/pubmed/12672637http://www.ncbi.nlm.nih.gov/pubmed/11008902


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cell cycle arrest, interfered with Akt+role in multiple cellular processes such

as glucose metabolism, apoptosis, cell proliferation, transcription and cell

migration. activation of 3A*9+role in comple) cellular programs like

proliferation, differentiation, development, transformation, and apoptosis

signals, and increased apoptosis signals leading to a controlled

caspases+mechanisms of apoptosis, $cl'+family of regulator proteins that

regulate cell death, $a)+involved in p2-mediated apoptosis genes and

protein e)pression.+ole and

curcumin in endometrial cancer in nude mice, treatment of curcumin or

letro>ole induced apoptosis in endometrial cancer and the composition

further enhanced the inhibitory rate in tumor growth+11. /n human

endometrial carcinoma :E&1A cells, curcumin induced apoptosis through

downregulation of Ets1 and $cl' e)pression+1'

-. 5arlic5arlic *%lli"m sati4"m+is a species in the onion genus, belonging to

family Amaryllidaceae, native to central Asia. /t has been used popularly in

traditional and &hinese medicine in treating common cold and flu to the

*lague, blood pressure cholesterol levels, natural antibiotic, etc.

Allium vegetables have been found in many studies to have an inverse

association between the freHuency of use and the risk of several common


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cancers+1-. *urified allicin, a maQor ingredient of crushed garlic, showed to

induced apoptosis through induction of activation of caspases-, < and

and cleavage of poly+A(*ribose polymerase+1 A multicentre case

control study of 2 endometrial cancer cases and 0< controls, allium

vegetables, including garlic showed a moderate protective effect in reduced

risk endometrial cancer+12. $ut according to the 9orea ood and (rug

Administration, there was no credible evidence to support a garlic intake in

reduced risk of endometrial cancer+18.

. 5in!er

5in!er *\ingiber officinale or ginger root is the genus \ingiber, belonging

to the family \ingiberaceae, native to Tamil. /t has been used in traditional

and &hinese medicine to treat dyspepsia, gastroparesis, constipation, edema,

difficult urination, colic, etc.

A recent report identified a variety of terpenoids inhibited cancer cellproliferation and metastasis via various mechanisms+17, including

inhibition of tumorinduced angiogenesis and of various oncogenic and anti

apoptotic signaling pathways and suppression or nuclear translocation of

various transcription factors including nuclear factor kappa $ +_$+1


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9. $ed clo4er

$ed Clo4eris a shortlived perennial plant, in the genus Trifolium,

belonging to the family abaceae, native to to Europe, #estern Asia and

northwest Africa. The herb has been used in traditional medicine as diuretic

and liver cleansing agent and to treat cancer, whooping cough, respiratory

problems, and skin inflammations, etc.

"ynthesi>ed carbamate esters with long aliphatic chains without such atoms

from $iochanin A +$&A, a maQor isoflavone in red clover, suppressed cell

proliferation /shikawa cell line+''. the !niversity of /llinois at &hicago

study indicated that the flower head and total aboveground parts e)tracts

e)hibited differential estrogenic activity in an /shikawa +endometrial cel

line and autohydrolytic e)tracts of aboveground parts contained more

isoflavones and had more estrogenic activity in /shikawa endometrial cells

as compared with e)tracts of flower heads+'- and red clover isoflavones

had an anti proliferative effect in the endometrium+'.

9. 7c"tellaria baicalensis *Bai=al 7="llca), H"an! >in+

$aikal "kullcap, also known as :uang ]in in traditional &hinese

medicine, is a flower plant of the genus "cutellaria, belonging to the family

6amiaceae, native to &hina. The herb has been used to treat Qaundice,

hypertension ,

an)iety, headache due to cold or flu, prostate &ancer, breast cancer, red eyes

and sore throat, cough

and asthma.

/n endometrial cancer cell lines, high doses of :uang ]in significantly

inhibited of cell growth but

lower doses stimulated growth in endometrial cell lines+'2. /n an estrogen

responsive mouse

tumor cell line, the herb "cutellaria baicalensis, significantly inhibited the

proliferation of $1

cells+estrogenresponsive mouse tumor cellline B0#F in vitro and

in vivo, through induction of (A

fragmentation and morphological changes+'8.

:. Fritillaria cirrose *C"an Bei "+

ritillaria cirrhose is a bulbous plants in the genus of ritillaria belonging to

the family 6iliaceae, native to the orthern :emisphere. The herb has been

used in traditional &hinese medicine as as antibiotic and to raise blood

pressure, stop cough, , increased blood sugar,etc. as it transforms *hlegm,

calms coughC clears :eat, dissolves nodules, etc. by enhancing the functions


15/33

of heart and lung channels.

/n the composition study of "cutellaria baicalensis +"$ and ritillaria

cirrhosa +&, suggested that both herb inhibit the proliferation of

endometrial cell line through activation of caspase-+cell apoptosis I0=I1

phase cell cycle arrest, down regulation of cyclins (1 and (-+regulating cell

cycle progression and induction of p'7+&ell cycle inhibition+'7

;. B"falin *Can 7"+

$ufalin is also known as toad venom. The acrid, warm, to)ic herb has been

used in T&3 to food poisoning with stomach pain and bloating, vomiting,

diarrhea, fainting, painful and swollen throat and certain types of cancer,

including liver cancer, intestine cancer, leukemia, skin cancer etc. as it

e)pels to)ins, resolves oedema, calms pain, opens the orifices, etc. by

enhancing the functions of heart, kidney and stomach channels. $ufalin, the

cardioactive &' steroids was found to inhibit the growth of tumors ofendometrium through cell cycle arrest, apoptosis, and e)pression of genes

proliferation genes+'


16/33

e)pressions. 6arge sample si>e and muticenter studies are necessary with

identification of the active principle in order to improve the validation of the

clinical trial.

&hinese "ecrets To atty 6iver And 5besity %eversal

!se The %evolutionary indings To Achieve

5ptimal :ealth And 6oose #eight

64arian Cysts %nd PC67 Elimination

:olistic "ystem /n E)istence That #ill "how Gou :ow To

*ermanently Eliminate All Types of 5varian &ysts #ithin ' 3onths

$ack to %esearched articles *oints of view of Litamins, oods and :erbs

httpF==kyleQnorton.blogspot.ca=p=blogpage`'.html

$ack to 9yle D. orton :ome page httpF==kyleQnorton.blogspot.ca

$eferences

+1 &onference on [3ultidisciplinary approaches to nutritional problems[.

"ymposium on [utrition and health[. &ruciferous vegetable intake and the

risk of human cancerF epidemiological evidence $G 9im 39, *ark

D:+*ub3ed

+' Epidemiological studies on brassica vegetables and cancer risk by

Lerhoeven (T, Ioldbohm %A, van *oppel I, Lerhagen :, van den $randt

*A+*ub3ed

+- $rassica vegetables and cancer prevention. Epidemiology and

mechanisms by van *oppel I, Lerhoeven (T, Lerhagen :, Ioldbohm %A.

+*ub3ed

+ ruits and vegetables and endometrial cancer riskF a systematic literature

review and metaanalysis by $andera EL, 9ushi 6:, 3oore (, Iifkins

(3, 3c&ullough 36+*ub3ed

+2 *reventive effects of glycyrrhi>in on estrogenrelated endometrial

carcinogenesis in mice by iwa 91, 6ian \, 5nogi 9, Gun #, Tang 6, 3ori:, Tamaya T+*ub3ed

+8 *reventive effects of Ilycyrrhi>ae radi) e)tract on estrogenrelated

endometrial carcinogenesis in mice by iwa 91, :ashimoto 3, 3orishita ",

Gokoyama G, 3ori :, Tamaya T+*ub3ed

+7 Ireen tea and green tea catechin e)tractsF an overview of the clinical

evidence by Dohnson %1, $ryant ", :untley A6.+*ub3ed
http://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://kylejnorton.blogspot.ca/p/general-health.htmlhttp://kylejnorton.blogspot.ca/http://www.ncbi.nlm.nih.gov/pubmed/19061536http://www.ncbi.nlm.nih.gov/pubmed/8877066http://www.ncbi.nlm.nih.gov/pubmed/10736624http://www.ncbi.nlm.nih.gov/pubmed/17571962http://www.ncbi.nlm.nih.gov/pubmed/17273742http://www.ncbi.nlm.nih.gov/pubmed/10470284http://www.ncbi.nlm.nih.gov/pubmed/22986087http://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://kylejnorton.blogspot.ca/p/general-health.htmlhttp://kylejnorton.blogspot.ca/http://www.ncbi.nlm.nih.gov/pubmed/19061536http://www.ncbi.nlm.nih.gov/pubmed/8877066http://www.ncbi.nlm.nih.gov/pubmed/10736624http://www.ncbi.nlm.nih.gov/pubmed/17571962http://www.ncbi.nlm.nih.gov/pubmed/17273742http://www.ncbi.nlm.nih.gov/pubmed/10470284http://www.ncbi.nlm.nih.gov/pubmed/22986087


17/33

+


18/33

:G+*ub3ed

+'1 /nhibitory effect of ginsenoside%b' on invasiveness of uterine

endometrial cancer cells to the basement membrane by uQimoto D1,

"akaguchi :, Aoki /, Toyoki :, 9hatun ", Tamaya T.+*ub3ed

+'' &hemoprevention of mammary, cervi) and nervous system

carcinogenesis in animals using cultured *ana) ginseng drugs and

preliminary clinical trials in patients with precancerous lesions of the

esophagus and endometrium by $espalov LI1, Ale)androv LA, 6imarenko

AG, Loytenkov $5, 5kulov L$, 9abulov 39, *eresunko A*, "lepyan 6/,

(avydov LL.+*ub3ed

+'' Ester and carbamate ester derivatives of $iochanin AF synthesis and in

vitro evaluation of estrogenic and antiproliferative activities by okialakis

1, Ale)i ^, Aligiannis , "iriani (, 3eligova A9, *ratsinis :, 3itakou ",

Ale)is 3.+*ub3ed

+'- "easonal variation of red clover +Trifolium pratense 6., abaceaeisoflavones and estrogenic activity by $ooth 61, 5verk &%, Gao *, Totura

", (eng G, :edayat A", $olton D6, *auli I, arnsworth %.+*ub3ed

+' A doubleblind randomi>ed study on the effects of red clover

isoflavones on the endometrium by :ale IE1, :ughes &6, %obboy "D,

Agarwal "9, $ievre 3+*ub3ed

+'2 The &hinese herbs "cutellaria baicalensis and ritillaria cirrhosa target

_$ to inhibit proliferation of ovarian and endometrial cancer cells by

9avandi 61, 6ee 6%, $okhari AA, *irog DE, Diang G, Ahmad 9A, "yed L.

+*ub3ed

+'8 *ossible mechanism of growth inhibition by "cutellaria baicalensis in

an estrogenresponsive mouse tumor cell line by 3urashima T1, 9atayama

:, "hoQiro 9, ishi>awa G+*ub3ed

+'7 The &hinese herbs "cutellaria baicalensis and ritillaria cirrhosa target

_$ to inhibit proliferation of ovarian and endometrial cancer cells by

9avandi 61, 6ee 6%, $okhari AA, *irog DE, Diang G, Ahmad 9A, "yed L.

+*ub3ed

+'


19/33

+-1 *reventive effect of Du>entaihoto on endometrial carcinogenesis in

mice is based on "himotsuto constituent by Tagami 91, iwa 9, 6ian \,

Iao D, 3ori :, Tamaya T.+*ub3ed

+-' &ell proliferation in cancer preventionC effects of preventive agents on

estrogenrelated endometrial carcinogenesis model and on an in vitro model

in human colorectal cells by 3ori :1, iwa 9, \heng ], Gamada G, "akata

9, Goshimi .+*ub3ed

+-- Apoptotic effects of Tian6ong compound on endometrial

adenocarcinoma cells in vitro by 6i \61, 3orishima ", Tang DT, 5tsuki G.

+*ub3ed

333. Endometrial Cancer 3n Vitamins' Points of View

%. Vitamin %

Vitamin %is a general term of Litamin A %etinol, retinal, betacarotene,alphacarotene, gammacarotene, and betacrypto)anthin best known for its

functions for vision health and antio)idant scavenger and essential for

growth and differentiation of a number of cells and tissues.

%ecommended intakes of vitamin A, according to the /nstitute of 3edicine

of the ational Academies +formerly ational Academy of "ciences is 800

g daily as e)tremely high doses +000 mg can be to)icity as causes

of dry, scaly skin, fatigue, nausea, loss of appetite, bone and Qoint pains,

headaches, etc.

Epidemiological studies, linking vitamin A in reduced risk of endometrial

cancer have been inclusive.

1. $etinols

The /stituto di %icerche armacologiche 3ario egr study in dietary intake

of carotenoids and retinol showed no association of retinols in reduced risk

of endometrial cancer+2. /n the /shikawa endometrial cancer cell line,

%etinoic acid, a metabolite of %etinol inhibited cell proliferation and the

e)pression of %A%+retinoic acid receptor alpha, %A% beta, and %A%

gamma in the /shikawa endometrial cancer cell line+8. The !niversity

einberg "chool of 3edicine study in assessing the roles of %A and the %A

agonist +A32


20/33

epidermal growth factor receptor +EI% signaling pathway+10.

&. Carotenoids*beta0carotene, al)a0carotene, !amma0carotene and

beta0cry)to?antin+

&arotenoids, plant pigments, converted to vitamin A after intake, play an

important role in prevention and treatment of some diseases through it

antio)idant effects. The $righam and #omens :ospital and :arvard

3edical "chool, study of antio)idants intake and risk of endometrial cancer,

found no association between intakes of vitamins A, &, E or carotenoids

from foods or supplements and cancer risk+11. /n a doseresponse meta

analysis, intakes of betacarotene is associated to an inverse risk of

endometrial cancer+1'. The 3edical !niversity of $iaystok study

suggested that endometrioid adenocarcinoma may be associated to certain

en>ymatic defects in carotenoid metabolism in the course of the neoplastic

process or some metabolic modifications+1-. The populationbased casecontrol study in "hanghai, &hina of 1,'0 newly diagnosed endometrial

cancer cases and 1,'1' age freHuencymatched controls, indicated that

dietary macronutrients with endometrial cancer associated to cancer risk

may depend on the sources, dietary retinol, betacarotene may decrease the

risk of endometrial cancer+1+12

Taking altogether, without going into reviews, vitamin A may be associated

to reduced risk and treatment of endometrial cancer through inhibition of

cell cycle progression, modification of cells differentiated mechanisms.

5verdoses can lead to to)ic symptoms. *lease make sure you follow the

guideline of the /nstitute of 3edicine of the ational Academies.

$eferences

+1 &onference on [3ultidisciplinary approaches to nutritional problems[.

"ymposium on [utrition and health[. &ruciferous vegetable intake and the

risk of human cancerF epidemiological evidence $G 9im 39, *ark

D:+*ub3ed

+' Epidemiological studies on brassica vegetables and cancer risk by

Lerhoeven (T, Ioldbohm %A, van *oppel I, Lerhagen :, van den $randt*A+*ub3ed



+*ub3ed


http://www.ncbi.nlm.nih.gov/pubmed/19061536http://www.ncbi.nlm.nih.gov/pubmed/8877066http://www.ncbi.nlm.nih.gov/pubmed/10736624http://www.ncbi.nlm.nih.gov/pubmed/19061536http://www.ncbi.nlm.nih.gov/pubmed/8877066http://www.ncbi.nlm.nih.gov/pubmed/10736624


21/33


+2 (ietary intake of carotenoids and retinol and endometrial cancer risk in

an /talian casecontrol study by *elucchi &1, (al 3aso 6, 3ontella 3,

*arpinel 3, egri E, Talamini %, Iiudice A, ranceschi ", 6a Lecchia &.

+*ub3ed

+8 E)pression of retinoic acid receptors in human endometrial carcinoma by

Tanabe 91, !tsunomiya :, Tamura 3, iikura :, Takano T, Goshinaga 9,

agase ", "u>uki T, /to 9, 3atsumoto 3, :ayashi ", Gaegashi +*ub3ed

+7 %etinoic acid inhibits endometrial cancer cell growth via multiple

genomic mechanisms by &heng G:1, !tsunomiya :, *avone 3E, Gin *,

$ulun "E+*ub3ed

+yski "+*ub3ed

+1 utritional factors in relation to endometrial cancerF a report from a

populationbased casecontrol study in "hanghai, &hina by ^u #:1, (ai ],

^iang G$, \hao I3, %uan \^, &heng D%, \heng #, "hu ^5.+*ub3ed

+12 /ntake of selected micronutrients and the risk of endometrial carcinoma

by egri E1, 6a Lecchia &, ranceschi ", 6evi , *ara>>ini .+*ub3ed

B. Te B Vitamin

B.#. Vitamin B&

Vitamin B& also known as %iboflavin, is a watersoluble, yelloworange

organic compound found abundantly in milk, meat, eggs, nuts, enriched

flour, green vegetables, etc. The vitamin is essential for normal cellular

growth and function and best known for converting energy from protein, fat,
http://www.ncbi.nlm.nih.gov/pubmed/17571962http://www.ncbi.nlm.nih.gov/pubmed/18592384http://www.ncbi.nlm.nih.gov/pubmed/18271925http://www.ncbi.nlm.nih.gov/pubmed/21310893http://www.ncbi.nlm.nih.gov/pubmed/16569247http://www.ncbi.nlm.nih.gov/pubmed/11836298http://www.ncbi.nlm.nih.gov/pubmed/10816385http://www.ncbi.nlm.nih.gov/pubmed/20473915http://www.ncbi.nlm.nih.gov/pubmed/19083131http://www.ncbi.nlm.nih.gov/pubmed/19056531http://www.ncbi.nlm.nih.gov/pubmed/17230528http://www.ncbi.nlm.nih.gov/pubmed/8608484http://www.ncbi.nlm.nih.gov/pubmed/17571962http://www.ncbi.nlm.nih.gov/pubmed/18592384http://www.ncbi.nlm.nih.gov/pubmed/18271925http://www.ncbi.nlm.nih.gov/pubmed/21310893http://www.ncbi.nlm.nih.gov/pubmed/16569247http://www.ncbi.nlm.nih.gov/pubmed/11836298http://www.ncbi.nlm.nih.gov/pubmed/10816385http://www.ncbi.nlm.nih.gov/pubmed/20473915http://www.ncbi.nlm.nih.gov/pubmed/19083131http://www.ncbi.nlm.nih.gov/pubmed/19056531http://www.ncbi.nlm.nih.gov/pubmed/17230528http://www.ncbi.nlm.nih.gov/pubmed/8608484


22/33

and carbohydrates metabolism and its antio)idant effects in o)idation

reduction reactions.

Epidemiological studies. linking dietary vitamin $' in reduced risk of

endometrial cancer have produced inconclusive results. The study of

:arvard "chool of *ublic :ealth showed a inverse association of vitamin

$' related to the risk of endometrial cancer in a relatively small si>e of

study+2. the co administration of riboflavin +2 mg=kg bw=day, niacin +100

mg=kg bw=day and ascorbic acid +'00 mg=kg bw=day along with tamo)ifen

+2 mg=kg bw=day, in e)perimental animals with endometrial cancer

bearing rats, e)hibited a significant decrease in the activity of glycolytic

en>ymes and a significant increase in the deficient activities of

gluconeogenic en>ymes to near normal levels, but not individually+8.

!nfortunately, the study of u (an !niversity "chool of *ublic :ealth

indicted [no significant association was observed for dietary vitamin $1 orvitamin $' and risk of endometrial cancer[, in a populationbased case

control study of 1,'0 newly diagnosed endometrial cancer cases and 1,'1'

age freHuencymatched controls+7+


23/33



+*ub3ed



(3, 3c&ullough 36+*ub3ed+2 (iet in relation to endometrial cancer

riskF a casecontrol study in Ireece by *etridou E1, 9edikoglou ",

9oukoulomatis *, (essypris , Trichopoulos (+*ub3ed

+8 Therapeutic potential of riboflavin, niacin and ascorbic acid on

carbohydrate metaboli>ing en>ymes in secondary endometrial carcinoma

bearing rats by "undravel "1, "hanthi *, "achdanandam *.+*ub3ed

+7 utritional factors in relation to endometrial cancerF a report from a



+elnuts, meat, fish etc., with

functions of amino acid, carbohydrate metabolism, brain health, and liver

deto)ification, etc.

Epidemiological studies linking vitamin $8 in reduced risk of endometrial

cancer have been inconclusive, but the composition of vitamin $8 and other

micro nutrient have found to be effective in some studies. 5necarbon

metabolism in '8 years of followup data from the urses :ealth "tudy, do

not appear to influence endometrial cancer incidence but showed protective

effect for women with 3T:% 877 TT or 3T:% 1'< && genotype+1

and a case of casecontrol study in Ireece, indicated that intkae of %etinol,

nicotinic acid, vitamin $ 8, and riboflavin were inversely associated withthe disease+'.

$ut in a study between 17 and '00-, 1,'0 newly diagnosed endometrial

cancer cases and 1,'1' controls recruited among women between the ages of

-0 and 8 years in urban "hanghai, &hina, showed dietary intake of vitamin

$8 was not related to risk of endometrial cancer for women with en>yme

2,10methylenetetrahydrofolate reductase +3T:%, encoded by the
http://www.ncbi.nlm.nih.gov/pubmed/10736624http://www.ncbi.nlm.nih.gov/pubmed/17571962http://www.ncbi.nlm.nih.gov/pubmed/12672637http://www.ncbi.nlm.nih.gov/pubmed/16691316http://www.ncbi.nlm.nih.gov/pubmed/17230528http://www.ncbi.nlm.nih.gov/pubmed/17301261http://www.ncbi.nlm.nih.gov/pubmed/10736624http://www.ncbi.nlm.nih.gov/pubmed/17571962http://www.ncbi.nlm.nih.gov/pubmed/12672637http://www.ncbi.nlm.nih.gov/pubmed/16691316http://www.ncbi.nlm.nih.gov/pubmed/17230528http://www.ncbi.nlm.nih.gov/pubmed/17301261


24/33

3T:% gene+-. (ue to small si>e of some studies, some researchers

suggested that large e)ample si>e and multi centers studies are necessary to

validate the effectiveness of any micro nutrient in endometrial cancer risk.

Taking altogether, without going into reviews, the composition of vitamin

$8 and other micro nutrients may be effective in reduced risk and treatment

of endometrial cancer. 5ver doses may induced the symptoms of difficulty

coordinating movement, numbness, sensory changes, etc., please make sure

you follow the guideline of the /nstitute of 3edicine of the ational

Academies.

Cinese 7ecrets To Fatty 2i4er %nd 6besity $e4ersal

!se The %evolutionary indings To Achieve

5ptimal :ealth And 6oose #eight

5varian &ysts And *&5" Elimination

:olistic "ystem /n E)istence That #ill "how Gou :ow To

*ermanently Eliminate All Types of 5varian &ysts #ithin ' 3onths

$ack to %esearched articles *oints of view of Litamins, oods and :erbs

httpF==kyleQnorton.blogspot.ca=p=blogpage`'.html

$ack to 9yle D. orton :ome page httpF==kyleQnorton.blogspot.ca

$eferences+1 5necarbon metabolism factors and endometrial cancer risk by 6iu DD1,

:a>ra A, Iiovannucci E, :ankinson "E, %osner $, (e Livo /.+*ub3ed

+'(iet in relation to endometrial cancer riskF a casecontrol study in Ireece

by *etridou E1, 9edikoglou ", 9oukoulomatis *, (essypris , Trichopoulos

(.+*ub3ed

+- (ietary folate intake, 3T:% genetic polymorphisms, and the risk of

endometrial cancer among &hinese women by ^u #:1, "hrubsole 3D,

^iang G$, &ai ], \hao I3, %uan \^, &heng D%, \heng #, "hu ^5.

+*ub3ed

B.. Folate

olate, also known as folic acid, vitamin $, is a water soluble vitamin,

found abundantly in leafy vegetables, citrus fruits, beans, whole grain, etc.

The vitamin plays an important role in synthesi>e, repair, and methylate

(A as well as to act as a cofactor in certain biological reactions,

production of red blood cells for anemia prevention.
http://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://kylejnorton.blogspot.ca/p/general-health.htmlhttp://kylejnorton.blogspot.ca/http://www.ncbi.nlm.nih.gov/pubmed/23299529http://www.ncbi.nlm.nih.gov/pubmed/12672637http://www.ncbi.nlm.nih.gov/pubmed/17301261http://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://5187969dlfug2d0xr7vygq7o9j.hop.clickbank.net/?tid=NKhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://99a5eb8fmaxf8gq40dq743lesm.hop.clickbank.net/?tid=ALOEhttp://kylejnorton.blogspot.ca/p/general-health.htmlhttp://kylejnorton.blogspot.ca/http://www.ncbi.nlm.nih.gov/pubmed/23299529http://www.ncbi.nlm.nih.gov/pubmed/12672637http://www.ncbi.nlm.nih.gov/pubmed/17301261


25/33

Epidemiological studies, focusing olate receptor alpha +%A in diagnosis

of risk and dietary in reduced risk of endometrial cancer have been

inconclusive. olate receptor alpha +%A can be overe)pressed by a

number of epithelialderived tumors including ovarian, breast, renal, lung,

colorectal, and brain, the study emphasi>ed the correlation of the receptor

e)pression in endometrial cancer showed no significant difference in women

with endometrial cancer after chemotherapy+1 but an associated growth

advantage, rather than the process of tumorigenesis resulting in aberrant

e)pression of %A per se.+'. $ut in [high risk[ endometrial carcinomas,

3oderate=strong %alpha staining was significantly associated with other

poor prognostic factors includingF advanced stage, nonendometrioid

histology and high grade of the diseases+-

5necarbon metabolism dietary factors, including levels of folate, choline,

methionine, vitamin $', vitamin $8 or vitamin $1', do not effect theendometrial incidence+. $ut in Type / and // endometrial cancer study,

intake of use of supplements containing folate and vitamins $', $8, and $1'

was associated with an increased risk of type // endometrial cancer.+2. The

olate +56 mediated polylactidecoglycolidepolyethylene glycol

nanoparticles +56*EI*6IA *s bearing paclita)el +*T^, was found

to be effective in indcution of cytoto)icity against :E&1A cancer cells in

vitro and in vivo, through possibly induced apoptosis+8. The Qoint study of

the effects of dietary folate and other methylrelated nutrients, as well as

three polymorphisms of 3T:% +877&T, 1'


26/33

6ambrechts ", 6eunen 9, $erteloot *, even *, Amant , 5"hannessy (D,

"omers E$, Lergote /.+*ub3ed

+' E)pression of folate receptor +%A in gynecologic malignancies and

its relationship to the tumor type by 5"hannessy (D1, "omers E$, "male %,

u G".+*ub3ed

+- %ationale for folate receptor alpha targeted therapy in [high risk[

endometrial carcinomas.

$rown Dones 31, euper &, &layton A, 3ariani A, 9onecny I, Thomas

3$, 9eeney I, :artmann 6, *odrat> 9&.+*ub3ed

+ 5necarbon metabolism factors and endometrial cancer risk by 6iu DD1,


+2 (ietary and supplemental intake of onecarbon nutrients and the risk of

type / and type // endometrial cancerF a prospective cohort study by !ccella

"1

, 3ariani A, #ang A:, Lierkant %A, %obien 9, Anderson 9E, &erhanD%.+*ub3ed

+8 /mproved therapeutic effect of folatedecorated *6IA*EI

nanoparticles for endometrial carcinoma by 6iang &1, Gang G, 6ing G,

:uang G, 6i T, 6i ^.+*ub3ed

+7 (ietary folate intake, 3T:% genetic polymorphisms, and the risk of

endometrial cancer among &hinese women by ^u #:1, "hrubsole 3D,

^iang G$, &ai ], \hao I3, %uan \^, &heng D%, \heng #, "hu

^5+*ub3ed

B.-. Vitamin B#&Vitamin B#&,also known as cobalamin, a watersoluble vitamin, found

abundantly in a variety of foods, such as fish, shellfish, meat, eggs, dairy

products, etc. plays an important role in regulating the functions of nervous

system and formation of blood.

Epidemiological studies, focusing vitamin $1' in reduced risk of

endometrial cancer have produced inconsistent results, but in certain studies,

vitamin $1' composted with other micro nutrients was found to be effective.

euroto)icity caused by *aclita)el=carboplatin chemotherapy for cancer +T&therapy may induce peripheral neuropathy, the study of IoshaQinkigan +a

traditional Dapanese herbal medicine composed with vitamin $1', showed

to inhibit the progression of peripheral neuropathy, thus alleviating the

symptoms of endometrial cancer+1. 5necarbon metabolism, vitamin $1'

showed no influence endometrial cancer risk but for women with with the

3T:% 877 TT or 3T:% 1'< && genotype, the dietary factors
http://www.ncbi.nlm.nih.gov/pubmed/23558051http://www.ncbi.nlm.nih.gov/pubmed/23518909http://www.ncbi.nlm.nih.gov/pubmed/18646191http://www.ncbi.nlm.nih.gov/pubmed/23299529http://www.ncbi.nlm.nih.gov/pubmed/21324952http://www.ncbi.nlm.nih.gov/pubmed/21641806http://www.ncbi.nlm.nih.gov/pubmed/17301261http://www.ncbi.nlm.nih.gov/pubmed/23558051http://www.ncbi.nlm.nih.gov/pubmed/23518909http://www.ncbi.nlm.nih.gov/pubmed/18646191http://www.ncbi.nlm.nih.gov/pubmed/23299529http://www.ncbi.nlm.nih.gov/pubmed/21324952http://www.ncbi.nlm.nih.gov/pubmed/21641806http://www.ncbi.nlm.nih.gov/pubmed/17301261


27/33

including vitamin $1' are associated to the protective effect against

endometrial cancer+'. (ue to the influence of olate, methionine, vitamin

$+8 and vitamin $+1' in the onecarbon metabolism pathway which is

critical for (A synthesis, methylation and repair some researchers

suggested that intake of these nutrients may be associated with an reduced

risk of breast, colon and endometrial cancers+-.

Taking altogether. without going into reviews, vitamin $1' composed with

other micronutrients may be efective in reduced risk and treatment of

endometrial cancer but large e)ample si>e are necessary to validate their

claims. 5ver doses of the vitamin may induce symptoms of to)icity,

including headache, giddiness and abnormal heart functioning, etc., please

make sure to follow the guideline of the /nstitute of 3edicine of the

ational Academies.

$eferences

+1 5bQective evaluation of the alleviating effects of IoshaQinkigan on

peripheral neuropathy induced by paclita)el=carboplatin therapyF A

multicenter collaborative study by 9aku :1, 9umagai ", 5noue :, Takada

A, "hoQi T, 3iura , Goshi>aki A, "ato ", 9igawa D, Arai T, Tsunoda ",

Tominaga E, Aoki (, "ugiyama T.+*ub3ed

+' 5necarbon metabolism factors and endometrial cancer risk by 6iu DD1,


+- olate, vitamin $+8 , vitamin $+1' , methionine and alcohol intake in

relation to ovarian cancer risk by :arris :%1, &ramer (#, Litonis A,

(e*ari 3, Terry 96.+*ub3ed

C. Vitamin C

Litamin &, also known as 6ascorbic acid, is a watersoluble vitamin, found

in fresh fruits, berries and green vegetables. /t is best known for its free

radical scavengers activity and regenerating o)idi>ed 4itaminE for immune

support.

The incidence of endometrial cancer among white women are higher incomparison of black. According to the statistic, the risk of endometrial

cancer among women is 1 in 7000. Every year, about 0,000 women in !"

are diagnosed with the disease. #omen who carry certain mutation genes,

such as $%&A1 or the $%&A' are associated to increased risk of

endometrial cancer.
http://www.ncbi.nlm.nih.gov/pubmed/22969845http://www.ncbi.nlm.nih.gov/pubmed/23299529http://www.ncbi.nlm.nih.gov/pubmed/21953625http://www.ncbi.nlm.nih.gov/pubmed/22969845http://www.ncbi.nlm.nih.gov/pubmed/23299529http://www.ncbi.nlm.nih.gov/pubmed/21953625


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The !niversity of 5tago, may have found a link of low ascorbate levels and

increased activation of the :/1 pathway to endometrial cancer. #omen

who were diagnosed with endometrial cancer with low levels of ascorbate

were found to have a elevated LEI+a signal protein produced by cells that

stimulates vasculogenesis and angiogenesis, I6!T1+E)pression levels of

I6!T1 in cell membranes are increased by reduced glucose levels and

decreased by increased glucose levels, and $/*-+a potent inducer of

a"to)a!yin many cells protein levels and with increased tumor si>e+-.

%eactive o)ygen species+%5" are responsible for proteasome inhibitor

induced cell killing, vitamin & is found to inhibit cell death through

blocking the triggering proteasome inhibition+. A combination including

riboflavin, niacin and ascorbic acid, caused a significant decrease in the

activity of glycolytic en>ymes and a significant increase in the activities of

gluconeogenic en>ymes to near normal levels in e)perimental animals and

may be considered as potential agent against tamo)ifen mediated secondaryendometrial carcinoma+2 and intake of vitamin & is associated to reduced

risk of

endometrial cancer+8.

/n secondary endometrial carcinoma bearing rat, the combination of

riboflavin, niacin and ascorbic acid e)hibited their effects against tamo)ifen

mediated endometrial carcinoma, through a significant decrease in the

activity of glycolytic en>ymes+promoting continuous transport of glucose

into the cell+7. /n a cultured human endometrial adenocarcinoma +A-&A

cells, another combination of application of sodium ascorbate +Litamin &

and 'methyl1,naphthoHuinone +Litamin 9- stimulated cytoto)icity

through the formation of reactive o)ygen radicals, possibly accentuated by

less defined secondary mechanisms+ing +3(:(, also showed the increased reduced form of

ascorbic and pyruvic acid in malignant growth+.

Taking altogether, the combination of vitamin & and others may be

associated to reduced risk and treatment of endometrial cancer through

inhibition of cell cycle, and other mechanisms. (aily ingestion of highdosevitamin & may be considered safe, but in rare incidence, overdoses in a

prolonged period of time, may cause intrarenal o)alate crystal deposition, a

fatal nephroto)icity+10+11.

$eferences


29/33

+1 %isk of endometrial cancer in relation to individual nutrients from diet

and supplements by $iel %91, &si>madi /, &ook 6", &ourneya 9",

3agliocco A3, riedenreich &3.+*ub3ed

+' utritional factors in relation to endometrial cancerF a report from a



+- 6ow ascorbate levels are associated with increased hypo)iainducible

factor1 activity and an aggressive tumor phenotype in endometrial cancer

by 9uiper &1, 3olenaar /I, (achs I!, &urrie 3D, "ykes *:, Lissers

3&+*ub3ed

+ Antio)idants block proteasome inhibitor function in endometrial

carcinoma cells by 6lobet (1, EritQa , Encinas 3, "orolla A, Geramian A,

"choenenberger DA, 6lombart&ussac A, 3arti %3, 3atiasIuiu ^, (olcet

^.+*ub3ed

+2 Therapeutic potential of riboflavin, niacin and ascorbic acid oncarbohydrate metaboli>ing en>ymes in secondary endometrial carcinoma

bearing rats by "undravel "1, "hanthi *, "achdanandam *.+*ub3ed

+8 Antio)idant vitamins and the risk of endometrial cancerF a doseresponse

metaanalysis.

$andera EL1, Iifkins (3, 3oore (, 3c&ullough 36, 9ushi

6:+*ub3ed

+7 Therapeutic potential of riboflavin, niacin and ascorbic acid on

carbohydrate metaboli>ing en>ymes in secondary endometrial carcinoma

bearing rats by "undravel "1, "hanthi *, "achdanandam *.+*ub3ed+


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tumor growth suppression and promotion in absorption of minerals,

including calcium, iron, magnesium, phosphate and >inc.

Epidemiological studies foscusing in the level of circulating '2

hydro)yvitamin ( +'2+5:( and dietary vitamin ( in reduced risk of

endometrial cancer have been inconclusive. A nested casecontrol study,

including ed human endometrial

epithelial cells and endometrial cancer cells, showed a sgnificant increased

levels of circulating '2hydro)yvitamin ( +'2+5:( and inhibition of cell

proliferation through caspase- activation and induction of I0I1 cellcycle

arrest with associated downregulation of cyclins (1 and (- and p'7

induction+. /n the differentiation of serum '2hydro)yvitamin (

+'2+5:( concentrations with incidence and=or mortality rates for about '0

types of cancer and improved survival rates for eight types of cancer,

suggested that both measurements of serum '2+5:( concentrations and

increasing serum '2+5:( concentrations should be considered of those

diagnosed with cancer, of that may improved survival rates and reduced

disparities+2. The e)pression of "E3A-$, "E3A-+secreted proteins that

regulate angiogenesis, tumor growth, and metastasis, are found to be lower

in women with endometrial cancer, due tothe the loss of "E3As in

contribution to the malignant phenotype of endometrial cancer cells, 7'hours treatment with conbination of progesterone +* and 1,'2

dihydro)yvitamin (+- M1,'2+5:+'(+-N showed a a significant

upregulation of "E3A-$ and "E3A- and inhibited growth of cancer cells

by increasing caspase- activity+8.

Taking altogether, without going into reviews, vitamin ( and high levels of


31/33

circulating '2hydro)yvitamin ( +'2+5:( may be associated to reduced

risk and treatment of endometrial cancer through certain mechanisms such

as cell cycle arrest, upregaulation induced apoptotic and anti proliferative

e)pressions. 5ver doses of vitamin ( supplement may cause e)cessive

calcium absorption, calcification, !rinary stones etc. please make sure to

follow the guideline of the /nstitute of 3edicine of the ational Academies.

$eferences

+1 &irculating '2hydro)yvitamin ( and risk of endometrial cancerF &ohort

&onsortium Litamin ( *ooling *roQect of %arer &ancers by \eleniuch

DacHuotte A1, Iallicchio 6, :artmuller L, :el>lsouer 9D, 3c&ullough 36,

"etiawan L#, "hu ^5, #einstein "D, #eiss D3, Arslan AA, (e Livo /,

Iao GT, :ayes %$, :enderson $E, :orst %6, 9oenig 96, *atel AL,

*urdue 3*, "nyder 9, "teplowski E, Gu 9, \heng #, :ankinson "E.

+*ub3ed+1a *rospective analysis of vitamin ( and endometrial cancer risk by 6iu

DD1, $ertrand 9A, 9arageorgi ", Iiovannucci E, :ankinson "E, %osner $,

3a)well 6, %odrigue> I, (e Livo /.+*ub3ed

+1b (ietary vitamin ( e)posure prevents obesityinduced increase in

endometrial cancer in *ten= mice by Gu #1, &line 3, 3a)well 6I,

$errigan (, %odrigue> I, #arri A, :ilakivi&larke 6.+*ubmed

+' The /nverse %elationship between '2:ydro)yvitamin ( and &ancer

"urvivalF (iscussion of &ausation by %obsahm TE1, "chwart> II, Tretli ".

+*ub3ed

+- "easonal vitamin ( changes and the impact on health risk assessment by

%osecrans %1, (ohnal D&+*ub3ed

+ *rogesterone enhances calcitriol antitumor activity by upregulating

vitamin ( receptor e)pression and promoting apoptosis in endometrial

cancer cells by 6ee 6%1, Teng *, guyen :, :ood $6, 9avandi 6, #ang

I, Turbov D3, Thaete 6I, :amilton &A, 3a)well I6, %odrigue> I&,

&onrads T*, "yed L.+*ub3ed

+2 (ifferences in vitamin ( status may account for une)plained disparities

in cancer survival rates between African and white Americans by Irant #$,

*eiris A.+*ub3ed+8 *rogesterone and 1,'2dihydro)yvitamin (inhibit endometrial cancer

cell growth by upregulating semaphorin -$ and semaphorin - by guyen

:1, /vanova L", 9avandi 6, %odrigue> I&, 3a)well I6, "yed L.+*ub3ed

E. Vitamin E

Litamin E, a fat soluble vitamin, consisting eight different variants +alpha,
http://www.ncbi.nlm.nih.gov/pubmed/20562189http://www.ncbi.nlm.nih.gov/pubmed/23136228http://www.ncbi.nlm.nih.gov/pubmed/20858763http://www.ncbi.nlm.nih.gov/pubmed/?term=Circulating+25-hydroxyvitamin+d+and+endometrial+cancerhttp://www.ncbi.nlm.nih.gov/pubmed/24525255http://www.ncbi.nlm.nih.gov/pubmed/23682076http://www.ncbi.nlm.nih.gov/pubmed/22928063http://www.ncbi.nlm.nih.gov/pubmed/21933904http://www.ncbi.nlm.nih.gov/pubmed/20562189http://www.ncbi.nlm.nih.gov/pubmed/23136228http://www.ncbi.nlm.nih.gov/pubmed/20858763http://www.ncbi.nlm.nih.gov/pubmed/?term=Circulating+25-hydroxyvitamin+d+and+endometrial+cancerhttp://www.ncbi.nlm.nih.gov/pubmed/24525255http://www.ncbi.nlm.nih.gov/pubmed/23682076http://www.ncbi.nlm.nih.gov/pubmed/22928063http://www.ncbi.nlm.nih.gov/pubmed/21933904


32/33

beta, gamma, and deltatocopherol and alpha, beta, gamma, and delta

tocotrienol with varying levels of biological activity+', found abundantly

in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils,

etc. plays an important role in neurological functions and inhibition of

platelet aggregation, regulation of en>ymatic activity, free radical scavenger,

etc..

Antio)idants in epidemiological evidences, are associated to reduced risk of

endometrial cancer caused by (A damage have been controversial. /n

doseresponse metaanalyse, study suggested that dietary intakes of beta

carotene, vitamin &, and vitamin E from food sources, consisted an inverse

relationship of endometrial cancer risk+2+8. The study association between

intakes of selected food groups and nutrients with E& risk among 21

women with histologically confirmed E& and 21 women with an intact

uterus and noncancer diagnoses seen at %oswell *ark &ancer /nstitutebetween 1


33/33




+2 Antio)idant vitamins and the risk of endometrial cancerF a dose

response metaanalysis by $andera EL1, Iifkins (3, 3oore (,

3c&ullough 36, 9ushi 6:+*ub3ed

+8 :igher intakes of vegetables and vegetablerelated nutrients are

associated with lower endometrial cancer risks. by Geh 31, 3oysich 9$,

Dayaprakash L, %odabaugh 9D, Iraham ", $rasure D%, 3c&ann

"E+*ub3ed

+7 :igher intakes of vegetables and vegetablerelated nutrients are

associated with lower endometrial cancer risks by Geh 31, 3oysich 9$,

Dayaprakash L, %odabaugh 9D, Iraham ", $rasure D%, 3c&ann

"E+*ub3ed

+

endometrial cancer in foods', herbs' and vitamins' points of view

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