endocrine system - is.muni.cz
TRANSCRIPT
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Endocrine system
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Hormonal regulation
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Endocrine glands• Glands w/o ducts
• Secretory cells release their products,
hormones, into the extracellular space
and blood stream
• Alternatively, the hormones may affect
neighbor cells (paracrine)
• Structure:
• c.t. – capsule + septs
• irregular clumps or cords of the cells
• network of capillaries
• fenestrated capillaries
• sinusoids
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Hypophysis – pituitary gland
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Pituitary gland – anterior pituitary
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Chromophilic cells
- Acidophilic cells (produce proteins)
somatotrophs
mammotrophs (or lactotrophs)
- Basophilic cells (produce glycoproteins)
thyrotrophs produce thyroid stimulating hormone (TSH or thyrotropin).
gonadotrophs produce follicle stimulating hormone (FSH) and luteinizing hormone (LH)
corticotrophs (or adrenocorticolipotrophs)
Chromophobic cells
Pituitary gland – anterior pituitary
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Adenohypophysis
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Adenohypophysis
orange G + PAS
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Neurohypophysis x Adenohypophysis
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Neurohypophysis - structure
Structure
unmyelinated nerve fibres derived from neurosecretory cells of the supraoptic and paraventricular hypothalamic nuclei
pituicytes /neuroglia/
Function
Two hormones are oxytocin, which stimulates the contraction of smooth muscle cell in the uterus and participates in the milk ejection reflex, and antidiuretic hormone (ADH or vasopressin), which facilitates the concentration of urine in the kidneys and, thereby, the retention of water.
Usually only the oval or round nuclei of the pituicytes are visible. Hypothalamic nerve fibres typically terminate close to capillaries. Scattered, large masses represent dilations of these nerve fibres - Herring bodies - are filled by small vesicles which contain the neurosecretory products of the hypothalamic cells.
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Neurohypophysis
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Neurohypophysis
Herring bodies
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Pineal body (epiphysis cerebri)
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Pineal body
is surrounded by pia mater, which functions as its capsule and which sends c.t. septa into the pineal body, subdividing it into lobules
two cell types and unmyelinated nerve fibers
pinealocytes (about 95% of the cells; large, light and round nuclei)
astrocytes (glial cells; dark, elongated nuclei)
both pinealocytes and astrocytes have long processes which give the tissue between the nuclei its "stringy" appearance
the most prominent secretory product of the pineal body is melatonin - decrease secretory activity in most other endocrine glands and may "delay" puberty through antigonadotrophic effects.
secretory activity in the pineal gland is stimulated by darkness and inhibited by light
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Pineal body
brain sand (or acervulus cerebri or corpora arenacea) - calcium-containing concretions which increase in size and number with age /are radioopaque/
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Thyroid gland
Thyroid hormones (T3, T4)
increase metabolic activity in almost
all tissues and organs. Many of the
other effects of the hormones are
secondary to an increased oxygen
consumption of the affected cells.
C cells produce the hormone
calcitonin, which decreases blood
calcium concentration
lobes→lobules - follicles
20 g
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Thyroid gland
Follicles /50 µm to about 1 mm/, which are separated by scant interfollicular c.t. It consists of a simple cuboidal epithelium which surrounds a lumen filled with a viscous substance, colloid.
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Thyroid gland - follicles
C cells (or parafollicular cells) are only few of them, typically situated basally in the
epithelium, without direct contact with the follicular lumen. They are always situated within the
basement membrane, which surrounds the entire follicle.
thyroglobulin, consists
of triiodothyronine T3
and
tetraiodothyronine
(thyroxine) T4
C-cells
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Glandula thyreoidea
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Parathyroid gland
c.t. /capsule+septs/
network of the capillaries
cords or clumps of the cells
6 mm, 130 mg
/total weight/
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Parathyroid gland
Chief cells are the most
numerous type. They are small
cells /7-10 µm/ with round, big and
centrally placed nucleus and a
small amounts of cytoplasm /very
weakly acidophilic/.
Oxyphilic cellsless frequent (occurring first in
children 6-7 years old and
increasing with age), larger -
their cytoplasm is strongly
acidophilic, the nucleus is round.
They contain large amounts of
mitochondria and glycogen.
Fat cells (adipocytes)
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Glandula parathyreoidea
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Parathyroid gland
Synthesise parathyroid hormone (PTH or
parathormone) which is of pivotal
importance for normal calcium
concentrations in the fluids and tissues of
the body. The effect is mediated by a
stimulation of osteoclastic bone resorption,
intestinal calcium uptake and calcium
resorption in the kidneys
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Suprarenal gland
c.t. : capsule+septs network of capillaries
cords of the cells
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Suprarenal gland - cortex
Zona glomerulosa (1/10)
Zona fasciculata (6/10)
Zona reticularis (3/10)
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Glandula suprarenalis
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Suprarenal gland - function Hormones produced in the cortex are all steroids - cortical cells contain
large amounts of AER, lipid droplets and mitochondria with tubules. Since the hormones are synthesised in the cortex they are more termed corticosteroids.
mineralocorticoids
glucocorticoids
The most important mineralocorticoid is aldosterone, which regulates the resorption of sodium and excretion of potassium in the tubules of the kidney – zona glomerulosa.
The most important glucocorticoids is cortisol, which has a wide range of effects on most cells of the body. Cortisol effects protein catabolism in almost all cells aside from liver cells, gluconeogenesis, glycogen storage, mobilisation of fat from adipocytes, anti-inflammatory effects, inhibition of allergic reactions – zona fasciculata.
Small amounts of androgens, oestrogens and progesterone are also produced – zona reticularis.
Both the zona fasciculata and zona reticularis depend on ACTH.
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Suprarenal gland - medulla Cells are arranged in strands or small
clusters in reticular c.t. -chromaffin cells because the granules of these cells can be stained with potassium bichromate and also some ganglion cells.
Chromaffin cells correspond to the adrenaline - (80%) and noradrenaline -producing cells of the medulla. The two groups cannot be distinguished using routine histology.
Chromaffin cells are innervated by preganglionic sympathetic fibres and correspond functionally to postganglionic neurones. The correspondence is not only functional -chromaffin cells are, like ganglion cells of the PNS, derived from neural crest cells.
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Islets of Langerhans
Groups of pale cells
cca 1,5 106
Thin c.t. capsula
Epithelial-like cords of cells
Sinusoids
Cell types: A, B, D, PP
A cells: 20%, glukagon
B cells: 60-70%, insulin
D cells: minor, somatostatin
PP cells: minor, pancreatic polypeptide
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Islets of Langerhans
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List of slides
52. Hypophysis cerebri
53. Epiphysis
54. Glandula thyreoidea
55. Glandula
parathyroidea
56. Corpus suprarenale
23. Pancreas – islets of
Langerhans