enclosure: 1 - welcome to environment · 2018-05-09 · enclosure: 3 name of raw material with its...
TRANSCRIPT
Enclosure: 1
Name of Product and Its Quantity
Amisulpride 5 Azilsartan Medoxomil 1 Cinitapride Hydrogen Tartrate 1 Indoline 5 Linagliptin 1 Losartan Potassium 5 Luliconazole 1 Moxifloxacin 1 Nebivolol 1 Olmesartan Medoxomil 1 Rosuvastatin Calcium 5 Sertaconazole Nitrate 1 Setraline HCl 1 Sitagliptin 5 Sofosbuvir 1 Tapentadol HCl 1 Telmisartan 5 Teneligliptin Hydrobromide 5 Ursodeoxycholic Acid 5 Velpatasvir 1 Vilazodone 1 Voriconazole 1 Pregabalin 25 R-(-)-3- Carbamoylmethyl-5-Methylhexanoic Acid / R-CMH
25
(+)-3- (Carbamoylmethyl)-5- Methylhexanoic Acid
50
Phenylphrine HCl 5 L-Phenylephrine Base 5 DL-Phenylephrine Base 5 Gliclazide 7 Sucralfate 25 Levosulpiride 10
Total 211
Enclosure: 2
Packing & Final Use of Products
Sr. No. Product Name CAS No. Type Of Packing Final Use of
Product 1. Amisulpride 53583-79-2
Aluminium Can/ Bag/Foil/HDPE/Fiber Drums/Paper Bags
Used to Produced
Medicines or Formulate
2. Azilsartan Medoxomil 863031-21-4
3. Cinitapride Hydrogen Tartrate 66564-14-5
4. Indoline 496-15-1
5. Linagliptin 668270-12-0
6. Losartan potassium 114798-26-4
7. Luliconazole 187164-19-8
8. Moxifloxacin 354812-41-2
9. Nebivolol 99200-09-6
10. Olmesartan Medoxomil 144689-63-4
11. Rosuvastatin Calcium 147098-20-2.
12. Sertaconazole Nitrate 99592-39-9
13. Setraline HCl 79617-96-2
14. Sitagliptin 654671-78-0
15. Sofosbuvir 1190307-88-0
16. Tapentadol HCl 175591-09-0
17. Telmisartan 144701-48-4
18. Teneligliptin Hydrobromide 906093-29-6
19. Ursodeoxycholic Acid 128-13-2
20. Velpatasvir 1377049-84-7
21. Vilazodone 163521-12-8
22. Voriconazole 137234-62-9
23. Pregabalin 148553-50-8
24. R-(-)-3- Carbamoyl Methyl-5-Methylhexanoic Acid
181289-33-8
25. (+)-3- (carbamoylmethyl)-5- 181289-15-6
methylhexanoic Acid
26. Phenylphrine HCl 61-76-7
27. L-Phenylephrine Base 59-42-7
28. DL-Phenylephrine Base 89-42-7
29. Gliclazide 21187-98-4
30. Sucralfate 54182-58-0
31. Levosulpiride 23672-07-3
Enclosure: 3
Name of Raw Material with Its Quantity
Raw Material Consumption Detail Product Wise
1. Amisulpride :
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 4-Amino -2-Methoxy-5-
Ethyl Sulphonyl Benzoic Acid
0.74 3.7
2. N-Ethyl -2-Amino Methyl Pyrolidine
0.39 1.95
3. Ethyl Chloro Formate 0.31 1.55 4. Triethyl Amine 0.42 2.1 5. Acetone 3.32 16.6 6. Sodium Hydroxide 0.76 3.8 7. Iso Propyl Alcohol 0.79 3.95 8. Activated Carbon 0.05 0.25 9. Hyflo Super Cel 0.02 0.1
2. Azilsartan Medoxomil :
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Methyl-1 [(2
Cyanobiphenyl4-Yl ]- 2Ethoxybenzenzimidazole-7-Carboxylate.
1.8 1.8
2. Hydroxyl Amine Hydrochloride
0.304 0.304
3. Sodium Bicarbonate 0.4 0.4 4. DMSO 0.9 0.9 5. Tetrahydrofuran 1.2 1.2 6. Carbonyl Imidazole 0.64 0.64 7. Di Aza Bi Cyclo Undecane 0.3 0.3 8. Sodium Bisulphite 0.5 0.5 9. Sodium Chloride 0.4 0.4 10. Methanol 0.34 0.34 11. Sodium Hydroxide 0.54 0.54
12. Isopropyl Alcohol 0.36 0.36 13. 4- Methoxymethyl-5-
methyl-1,3-dioxol-2-one 0.4 0.4
14. P-Toluene Sulphonyl Chloride
0.6 0.6
15. 4-chloromethyl-5-methyl-1,3-dioxol-2-one
0.058 0.058
16. Dimethyl Acetamide 0.28 0.28 17. Potassium Carbonate 0.3 0.3 18. HCl 20% 1.24 1.24 19. Ethyl Acetate 0.18 0.18 20. MDC 0.64 0.64 21. Activated Cabon 0.2 0.2 22. Hyflo Super cel 0.06 0.06
3. Cinitapride Hydrogen tartrate:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 4-Amino-2-ethoxy-5-Nitro-
N- (4-piperidyl) benzamide 0.56 0.56
2. 3-Cyclohexene-1-methanol 0.20 0.20 3. Benzene Sulphonyl
chloride 0.32 0.32
4. Sodium carbonate 0.10 0.10 5. TEA 0.70 0.70 6. Tartaric Acid 0.43 0.43 7. Cyclo hexane 2.52 2.52 8. DMF 5.66 5.66 9. Methanol 6.66 6.66 10. Activated Carbon 0.29 0.29 11. Hyflo super cel 0.09 0.09
4. Indoline:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 2,6 Dichloro Phenol 0.86 4.3 2. Sodium Methoxide 2.02 10.1 3. Ethyl Chloro Acetate 0.6 3 4. Aniline 0.48 2.4
5. Caustic Soda 0.31 1.55 6. Ethoxy Ethanol 2.78 13.9 7. Acetyl chloride 0.61 3.05 8. Methanol 6.11 30.55 9. Aluminum Chloride 0.7 3.5 10. Activated Carbon 0.06 0.3 11. Hyflo Super cel 0.02 0.1
5. Linagliptin:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Bromo Compound 1.64 1.64 2. Chloro Compound 1.28 1.28 3. Potassium Carbonate 4.12 4.12 4. Dimethyl formamide 9.84 9.84 5. 3-Azido piperdene 0.84 0.84 6. 1-Methyl 2- pyrrodinone 12 12 7. Ethyl Acetate 30 30 8. Acetonitrile 7.39 7.39 9. Triphenyl phospine 1.38 1.38 10. THF 15.79 15.79 11. MDC 26.31 26.31 12. Activated Carbon 0.16 0.16 13. Hyflo Super cel 0.05 0.05
6. Losartan Pottasium
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 2-Butyl-4-Chloro-5-
Hydroxy-Methyl Imidazole 0.78
3.9 2. 4-Bromo Methyl-2-Cyano-
Biphenyl 1.08
5.4 3. Tri Butyl Tin Chloride 2.07 10.35 4. Sodium Azide 0.41 2.05 5. Sodium Borohydride 0.11 0.55 6. Toluene 27.71 138.55 7. HCl 0.3 1.5 8. MEK 2.1 10.5 9. Acetone 5.24 26.2
10. Carbon tetrachloride 8.67 43.35 11. Ortho tolyl benzonitrile 1.08 5.4 12. l,3-Dibromo-5,5- dimethyl
hydantoin 0.8
4 13. Benzoyl peroxide 0.04 0.2 14. TBAB 0.09 0.45 15. O-Xylene 9.64 48.2 16. NaOH 0.3 1.5 17. KOH 0.4 2 18. Activated Carbon 0.06 0.3
7. Luliconazole:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. (Α,S) 2,4 –Dichloro-A-
(Chloromethyl)Benzene- Methanol Methane Sulphonate
1 1
2. 1H-Imidazole-1-Acetonitrile
0.35 0.35
3. Carbon Disulphide 0.23 0.23 4. KOH Powder 0.183 0.183 5. Toluene 1.5 1.5 6. Activated Carbon 0.1 0.1 7. Hyflo Super Cel 0.03 0.03
8. Moxifloxacin:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Moxifloxacin Q-Acid 0.85 0.85 2. 2,8-Diazobicyclo(4.3.0)
nonane 0.22 0.22
3. Sodium hydroxide 0.31 0.31 4. Acetone 3.77 3.77 5. Dimethylformamide 1.89 1.89 6. Activated Carbon 0.19 0.19 7. Hyflo Super Cel 0.056 0.056
9. Nebivolol:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. R*(S*)]-6-fluoro-3,4-
dihydro-2-oxiranyl-2H-1-benzopyran
0.67 0.67
2. Benzyl amine 1.1 1.1 3. Iso Propyl Alcohol 23.11 23.11 4. Palladium Charcoal 10 % 0.5 0.5 5. Ammonium Formate 0.63 0.63 6. Methanol 12.04 12.04 7. Activated Carbon 0.08 0.08 8. Hyflo Super Cel 0.03 0.03 9. Conc HCl 0.31 0.31 10. Benzyl amine 1.1 1.1
10. Olmesartan Medoxomil:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Ethyl-4-(1-hydroxy-1-
methylethyl) 2-propy H-((2-(2-(triphenyllnethyl)-2H-tetrazol-5 yl biphenyl-4-yl-1-methyl imidazole-5-carboxylic acid
0.655 0.655
2. 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
0.446 0.446
3. 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide
1.491 1.491
4. Potassium Carbonate 0.472 0.472 5. Ethylacetate 18.676 18.676 6. Acetone 32.851 32.851 7. Ativated Carbon 0.111 0.111 8. Hyflo Super Cel 0.02 0.02 9. Nacl 1.756 1.756 10. Di Iso Propyl Ether 8.781 8.781 11. N,N-Dimethylacetamide 7.235 7.235 12. Sodium Iodide 0.052 0.052 13. THF 10.537 10.537
14. Ethanol 1.756 1.756 15. NaOH 0.103 0.103 16. Sodium Bicarbonate 0.044 0.044 17. methylene chloride 17.831 17.831 18. Acetic acid 10.95 10.95
11. Rosuvastatin Calcium:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 4-Fluoro Benzaldehyde 0.52 2.6 2. 4-Methyl-3-oxo-pentanoic
acid ethyl ester 0.66
3.3 3. KOH 0.3 1.5 4. Methyl Iodide 0.6 3 5. Methanol 5.5 27.5 6. S-Methyl iso thio urea 0.35 1.75 7. 2,3-Dichloro-5,6-dicyano
Benzoquinone 0.85
4.25 8. HMPA
[Hexamethylphosphoramide]
1
5 9. MDC 8 40 10. Meta chloro
peroxybenzoic acid 1.2
6 11. Methyl amine 0.1 0.5 12. Ethanol 2.5 12.5 13. Methane sulfonyl chloride 0.35 1.75 14. Sodium hydride (60%) 0.01 0.05 15. Di methoxy ethane 3 15 16. Hydrogen Gas 0.0104 0.052 17. DIBAL - H
[Diisobutylaluminium hydride]
0.01
0.05 18. Toluene 8 40 19. Methyl(3R)-3-(tert butyl di
methyl silyloxy)-5-oxo-6-triphenyl phosphoranylidene hexanoate
1.45
7.25 20. Triethyl amine 0.15 0.75 21. N,N-Dimethyl formamide 3 15
22. Hydrogen fluoride 0.05 0.25 23. THF 7.5 37.5 24. Ethyl Acetate 10.5 52.5 25. Diethyl methoxy borane 0.2 1 26. Sodium boro hydride 0.01 0.05 27. Calcium Chloride 0.13 0.65 28. Activated Carbon 0.1 0.5 29. Hyflo Super Cel 0.03 0.15
12. Sertaconazole Nitrate:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 1-2,4-DICHLORO-PHENYL-
2-IMIDAZOLE- -1-YL-ETHANOL.
1.43 1.43
2. Tartaric Acid 0.91 0.91 3. Acetone 10.86 10.86 4. Methanol 6.86 6.86 5. Potassium Butoxide 0.49 0.49 6. Dimethyl Formamide 6.86 6.86 7. Bromo Methyl Thiophene 1.14 1.14 8. Methylene Dichloride 11.43 11.43 9. Nitric Acid 0.4 0.4 10. Ethyl Ether 2.29 2.29 11. Ethanol 5.14 5.14 12. Activated Carbon 0.29 0.29 13. Hyflo Super Cel 0.14 0.14
13. Setraline HCl:
Sr. No.
Name of Raw Material Kg/kg MT/Month
1. Tetralone 2 2 2. Mono Methyl Amine 40 % 6 6 3. Methanol 23.6 23.6 4. Palladium Charcoal 10 % 0.04 0.04 5. Hydrogen Gas 0.56 0.56 6. Methanolic HCl 20 % 1.4 1.4 7. Ethyl Acetate 7.2 7.2 8. NaOH 0.72 0.72
9. Mandelic Acid 0.48 0.48 10. Acetonitrile 7.2 7.2 11. HCl GAS 0.36 0.36
14. Sitagliptin:
Sr. No.
Name of Raw Material Kg/kg MT/Month
1. (2,4,5-Trifluoro-phenyl)aceticacid
0.5 2.5
2. Thionyl chloride 0.32 1.6 3. DMF 0.17 0.85 4. MDC 20 100 5. TEA 2.75 13.75 6. Meldrums acid 0.39 1.95 7. Sodium hydroxide 0.32 1.6 8. 3-(Trifluoro methyl)5,6,7,8-
tetrahydro(4,3-a)pyrazine HCl
0.57
2.85 9. Methane sulphonic acid 0.25 1.25 10. Ammonia 0.04 0.2 11. Sodium bicarbonate 0.22 1.1 12. Ethyl acetate 6.25 31.25 13. Acetonitrile 4.25 21.25 14. Activated Carbon 0.25 1.25 15. Hyflo Super Cel 0.07 0.35
15. Sofosbuvir:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. L-alanine iso propyl ester
HCl 1.72 1.72
2. Phenyl dichloro phosphate 2.15 2.15 3. Triethyl amine 3.22 3.22 4. Methylene chloride 45.46 45.46 5. Pentaflurophenol 3.12 3.12 6. 2'-Deoxy-2'-Fluoro-2'-C-
Methyl Uridine 0.74 0.74
7. THF 19.93 19.93 8. Tert-Butyl magnesium 0.54 0.54
chloride 9. HCl 32 % 1.37 1.37 10. Ethyl Acetate 13.33 13.33 11. Sodium carbonate 0.3 0.3 12. Sodium Chloride 2.96 2.96 13. MDC 25.42 25.42 14. Di Iso Propyl Ether 22.59 22.59 15. Activated Carbon 0.07 0.07 16. Hyflo Super Cel 0.02 0.02
16. Tapentadol HCl:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 1-(3-
Methoxyphenyl)propan-1-one
0.8 0.8
2. Dimethyl amine 2 2 3. Formaldehyde 0.4 0.4 4. Ethyl Magnesium Bromide 0.58 0.58 5. D(-) Tartaric Acid 0.64 0.64 6. HCl 0.15 0.15 7. Palladium Hydroxide 0.01 0.01 8. Hydrogen Gas 0.008 0.008 9. IPA 4 4 10. Ethyl Acetate 6 6 11. Activated Carbon 0.2 0.2 12. Hyflo Super Cel 0.06 0.06
17. Telmisartan:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 7-methyl-2-propyl-3H-
benzo[d]imidazole COOH 0.47
2.35 2. N-methyl-O-phenylene
diamine 0.28
1.4 3. Toluene 0.07 0.35 4. Poly phosphoric acid 1.18 5.9 5. Bromo Ester compound 0.85 4.25 6. Activated Carbon 0.03 0.15 7. Hyflo Super Cel 0.01 0.05
18. Teneligliptin Hydrobromide:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Cysteamin HCl 1.5 7.5 2. Formaldehyde 1.05 5.25 3. 2S,4S-4-Hydroxy-L-Prolin 3.1 15.5 4. Fmoc 6.5 32.5 5. HCl SOLN 18 90 6. EDC HCl 3 15 7. Hobt 1 5 8. N=Methyl Morpholine 1.3 6.5 9. Naoh 0.25 1.25 10. Sodium Carbonate 4.25 21.25 11. Sodium Sulphate 1.75 8.75 12. Sodium Bicarbonate 1.55 7.75 13. Sulphur Trioxide Pyridine
Complex 2.85
14.25 14. Phenyl Hydrazine 2.45 12.25 15. 3-Amino Crotononitrile 2 10 16. KOH 1.85 9.25 17. BIS 2-CHLORO ETHYL
AMINE HCl 4
20 18. Sodium Hydride 1 5 19. Toluene 8 40 20. Acetic Acid 3.7 18.5 21. DMF 7.5 37.5 22. Triethyl Amine 3.5 17.5 23. Acetone 1.65 8.25 24. DMSO 7.5 37.5 25. Iso Propyl Alcohol 7.5 37.5 26. Ethyl Acetate 6.5 32.5 27. THF 7.5 37.5 28. Dipe 9 45 29. MDC 40.5 202.5 30. Methanol 5.25 26.25 31. T-BUTYL ALCOHOL 15 75 32. Sodium Triacetoxy
Borohydride 1.12
5.6 33. Piperidine 0.37 1.85 34. Aqueous HBr 1.125 5.625
35. BRINE SOLUTION [Nacl] 1.5 7.5 36. Activated Carbon 0.097 0.485 37. Hyflo Super Cel 0.02 0.1
19. Ursodeoxycholic Acid:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Starch 80 400 2. Corn Steep Liquor 200 1000 3. Cane Molasses 20 100 4. Polypeptone 20 100 5. Sodium Chloride 20 100 6. Cholic Acid 2 10 7. HCl 7 35 8. Ethyl Acetate 50 250 9. Chloroform 8 40 10. Acetone 8 40 11. Acetic Acid 1 5 12. Ethanol 67 335 13. Silica Gel 53 265 14. Activated Carbon 0.1 0.5 15. Hyflo 0.1 0.5
20. Velpatasvir:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. Acetonitrile 9.7 9.7 2. Diisopropylethylamine 1.5 1.5 3. ((S)-1-(tert-butoxycarbonyl)-
4-(methoxy-methyl) pyrrolidine-2-carboxylic acid
1.0 1.0
4. 9-bromo-3-chloro-10,11-dihydro-5H-naphtho[c,g]chromen-8(9H)-one
0.9 0.9
5. Ethyl acetate 17.7 17.7 6. Toluene 15.2 15.2 7. 2-Methoxyethanol 0.02 0.02 8. Ammonium acetate 0.4 0.4
9. Manganese(IV) oxide 1.6 1.6 10. residue (2S)-1-tert-butyl-2-
(3-chloro-8-oxo-8,9,10,11-tetrahydro-6H-naphtho[2,3-c]chromen-9-yl)-4(methoxymethyl)pyrrolidine-1,2-dicarboxylate
0.8 0.8
11. MDC 18.5 18.5 12. bis (Pinacolato) diboron 0.7 0.7 13. Potassium Acetate 0.5 0.5 14. tris (dibenzylideneacetone)
Palladium 0.1 0.1
15. 2-DiCyclo HexylPhosphino-2′, 4′, 6′-tri-i-opyl-1,1′-biphenyl
0.1 0.1
16. 1,4 Dioxane 9.7 9.7 17. Tetrakis (triphenyl
phosphine) palladium 0.1 0.1
18. Dichloro[1,1′-bis(diphenyl phosphino) ferrocene]palladium
0.1 0.1
19. 1,2-dimethoxyethane 17.7 17.7 20. Dimethylformamide 5.0 5.0 21. Potassium carbonate 0.4 0.4 22. Methyl(S)-1-((S)-2-(5-
bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
0.6 0.6
23. Ethanol 14.5 14.5 24. HCl 0.5 0.5 25. ( R)-2-
(methoxycarbonylamino)-2- phenylacetic acid
0.3 0.3
26. COMU 0.3 0.3 27. Activated Carbon 0.05 0.05 28. Hyflo 0.03 0.03
21. Vilazodone:
22. Voriconazole:
Sr. No. Name of Raw Material Kg/kg MT/Month 1. THF 26 26 2. 3,5-dibromo-1H-1,2,4-
triazole 1 1
3. 2-chloro-2,4-difluoroacetophenone
1 1
Sr. No. Name of Raw Material Kg/kg MT/Month 1. 5-aminobenzofuran-2-
carboxylic acid 1.88 1.88
2. Methanol 83.59 83.59 3. HCl gas 0.48 0.48 4. Toluene 1.88 1.88 5. Ammonia 30% 0.94 0.94 6. Bis-(2-chloroethyl)amine
hydrochloride 1.47 1.47
7. Sodium acetate 20.3 20.3 8. Methylene chloride 25.06 25.06 9. Ammonia 1.89 1.89 10. N,N-dimethylformamide 3.75 3.75 11. Acetone 16.28 16.28 12. Aluminium trichloride 3.21 3.21 13. 4-chlorobutyryle chloride 3.45 3.45 14. 5-Cyano-indole 1.38 1.38 15. Hydrochloric acid 32% 1.41 1.41 16. Ethyl acetate 26.34 26.34 17. Tetrahydrofuran 4 4 18. Sodium borohydride 0.24 0.24 19. NaOH 0.01 0.01 20. Sodium bicarbonate 1.28 1.28 21. N,N-dimethylacetamide 10.41 10.41 22. Potassium iodide 0.17 0.17 23. Ammonium chloride 0.22 0.22 24. Pd/C 5% 0.18 0.18 25. Activated charcoal 0.07 0.07 26. Hyflo 0.07 0.07
4. Potassium Carbonate 1 1 5. IPA 7 7 6. MDC 50 50 7. 6-Ethyl-5-Fluoropyrimidin-
4-Ol 1 1
8. Tea 2 2 9. Methane Sulphonyl
Chloride 1 1
10. Acetic Acid 6 6 11. Magnesium Sulphate 27 27 12. N-Bromo Succinimide 0.5 0.5 13. Azo Bis Isobutyronitrile 0.3 0.3 14. Sodium Bisulphite 1 1 15. Sodium Bicarbonate 4 4 16. Zinc 1 1 17. Lead 0.15 0.15 18. Iodine 1 1 19. HCl 4 4 20. NaCl 10 10 21. Ethyl Acetate 33.4 33.4 22. N-HEXANE 32 32 23. Toluene 33 33 24. Pd /Ch 4 4 25. Ammonium Formate 21 21 26. Iso Propyl Ether 52.5 52.5 27. Acetone 21 21 28. R-(-)-10-Camphorsulfonic
Acid 9 9
29. Activated Carbon 0.15 0.15 30. Hyflo Super Cel 0.1 0.1
23. Pregabalin:
Sr. No. Name of Raw Material MT/MT MT/Month 1. R-(-)-3-Carbamoylmethyl-5-
Methylhexanoic Acid (R-CMH) 0.1 2.5
2. Water 0.4 10 3. Chlorine Gas 0.05 1.25 4. Con.HCl 0.15 3.75 5. IPA 0.448 11.2
6. Activated Carbon 0.002 0.05 7. Hyflow 0.001 0.025 8. Caustic Flakes 0.075 1.875
24. R-(-)-3- (carbamoylmethyl)-5- methylhexanoic Acid
Sr. No. Name of Raw Material MT/MT MT/Month 1. 3-Carbamoylmethyl-5-
methylhexanoic acid ( CMH) 1.19 29.762
2. R(+) Phenyl Ethyl Amine 0.06 1.500 3. Chloroform 0.60 15.000 4. Caustic Flakes 1.01 25.238 5. Sulphuric Acid 0.99 24.762 6. Urea 0.30 7.440 7. Activated Carbon 0.02 0.595 8. Hyflow 0.01 0.298 9. Sodium Sulphate 0.24 5.952
25. (+)-3- (carbamoylmethyl)-5- methylhexanoic Acid
Sr. No. Name of Raw Material MT/MT MT/Month 1. Isovaleraldehyde 0.1 5 2. Cynoacetamide 0.25 12.5 3. Sulfuric Acid 0.2 10 4. Toluene 0.2 10 5. Urea 0.03 1.5 6. Caustic Flakes 0.051 2.55 7. Activated Carbon 0.002 0.1 8. Hyflow 0.001 0.05 9. Con.HCl 0.1 5
26. Phenylphrine HCl
Sr. No. Name of Raw Material MT/MT MT/Month 1. L –Phenylephrine Base 0.1 0.5 2. HCl Gas 0.03 0.15 3. IPA 0.475 2.375 4. Activated Charcoal 0.002 0.01
5. Hyflow 0.001 0.005
27. L-Phenylephrine Base
Sr. No. Name of Raw Material MT/MT MT/Month 1. D-L-Phenylephrine Base 0.1 0.5 2. L(+) tartaric Acid 0.125 0.625 3. IPA 0.15 0.75 4. Caustic Flakes 0.05 0.25 5. Sulphuric Acid 0.023 0.1155 6. Acetic Anhydride 0.03 0.15
28. DL-Phenylephrine Base
Sr. No. Name of Raw Material MT/MT MT/Month 1. 3- HydroxyAcetophenone (3 –
HAP) 0.1 0.5
2. Bromine (Liq) 0.15 0.75 3. AIBN 0.001 0.005 4. Ethyl Acetate 0.05 0.25 5. Alcl3 0.0026 0.013 6. N-Methyl benzyl Amine 0.07 0.35 7. Toluene 0.635 3.175 8. Caustic Flakes 0.16 0.8 9. Con.HCl 0.28 1.4
29. Gliclazide
Sr. No. Name of Raw Material MT/MT MT/Month 1. Hexahydrocyclopenta[c]pyrrol-
2(1H)-Amine Hydrochloride ( HCl –Compound )
0.100 0.7
2. N-Carbamoyl-4-Methylbenzenesulfonamide (Sulfonamide Compound)
0.150 1.05
3. Sodium Methoxide 0.002 0.014 4. Toluene 0.600 4.200 5. MDC 800 4.400 6. Methanol 426 2.400 7. Activated Carbon 3 0.120 8. Hyflow 1 0.040
30. Sucralfate
Sr. No. Name of Raw Material MT/MT MT/Month 1. Sucrose 0.1 2.5 2. Pyridine 1.9 47.5 3. Chloro Sulfonic Acid 0.296 7.4 4. Methanol 1.385 34.625 5. Ammonia Solution 0.385 9.625 6. Aluminum Hydroxyl Chloride (50
%) 0.925 23.125
7. Caustic Flakes 0.001 0.025 8. Activated Carbon 0.005 0.125 9. Hyflow 0.001 0.025
31. Levosulpiride
Sr. No. Name of Raw Material MT/MT MT/Month 1. 2-Methoxy-5-Sulfamoyl Benzoic
Acid Methyl Ester 0.1 1
2. S-(-)-1-Ethyl-2-Amino Methyl Pyrrolidine
0.075 0.75
3. Mono Ethylene Glycol 0.3 3
Overall Raw Material Consumption:
Name of Raw Material MT/Month ( R)-2-(methoxycarbonylamino)-2- phenylacetic acid
0.3
((S)-1-(tert-butoxycarbonyl)-4-(methoxy-methyl) pyrrolidine-2-carboxylic acid
1.0
(2,4,5-Trifluoro-phenyl)aceticacid 2.5 (Α,S) 2,4 –Dichloro-A-(Chloromethyl)Benzene- Methanol Methane Sulphonate
1
1-(3-Methoxyphenyl)propan-1-one 0.8 1,2-dimethoxyethane 17.7 1,4 Dioxane 9.7 1-2,4-DICHLORO-PHENYL-2-IMIDAZOLE- -1-YL-ETHANOL.
1.43
1H-Imidazole-1-Acetonitrile 0.35 1-Methyl 2- pyrrodinone 12 2,3-Dichloro-5,6-dicyano Benzoquinone
4.25
2,6 Dichloro Phenol 4.3 2,8-Diazobicyclo(4.3.0) nonane 0.22 2-Butyl-4-Chloro-5-Hydroxy-Methyl Imidazole
3.9
2-chloro-2,4-difluoroacetophenone
1
2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine
0.74
2-DiCyclo HexylPhosphino-2′, 4′, 6′-tri-i-opyl-1,1′-biphenyl
0.1
2-Methoxy-5-Sulfamoyl Benzoic Acid Methyl Ester
1
2-Methoxyethanol 0.02 2S,4S-4-Hydroxy-L-Prolin 15.5 3- HydroxyAcetophenone (3 –HAP) 0.5 3-(Trifluoro methyl)5,6,7,8-tetrahydro(4,3-a)pyrazine HCl
2.85
3,5-dibromo-1H-1,2,4-triazole 1 3-Amino Crotononitrile 10 3-Azido piperdene 0.84 3-Carbamoylmethyl-5-methylhexanoic acid ( CMH)
29.762
3-Cyclohexene-1-methanol 0.20 4- Methoxymethyl-5-methyl-1,3-dioxol-2-one
0.4
4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
0.446
4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide
1.491
4-Amino -2-Methoxy-5-Ethyl Sulphonyl Benzoic Acid
3.7
4-Amino-2-ethoxy-5-Nitro- N- (4-piperidyl) benzamide
0.56
4-Bromo Methyl-2-Cyano-Biphenyl 5.4 4-chlorobutyryle chloride 3.45 4-chloromethyl-5-methyl-1,3-dioxol-2-one
0.058
4-Fluoro Benzaldehyde 2.6 4-Methyl-3-oxo-pentanoic acid ethyl ester
3.3
5-aminobenzofuran-2-carboxylic acid
1.88
5-Cyano-indole 1.38 6-Ethyl-5-Fluoropyrimidin-4-Ol 1 7-methyl-2-propyl-3H-benzo[d]imidazole COOH
2.35
9-bromo-3-chloro-10,11-dihydro-5H-naphtho[c,g]chromen-8(9H)-one
0.9
Acetic Acid 40.5 Acetic Anhydride 0.15 Acetone 26.2
Acetonitrile 45.55 Acetyl chloride 3.05 Activated Carbon 6.46 AIBN 0.005 AlCl3 (Aluminium trichloride) 3.22 Aluminum Chloride 3.5 Aluminum Hydroxyl Chloride (50 %) 23.125 Ammonia 12.66 Ammonium acetate 0.4 Ammonium chloride 0.22 Ammonium Formate 21.63 Aniline 2.4 Aqueous HBr 5.625 Azo Bis Isobutyronitrile 0.3 Benzene Sulphonyl chloride 0.32 Benzoyl peroxide 0.2 Benzyl amine 2.2 bis (Pinacolato) diboron 0.7 BIS 2-CHLORO ETHYL AMINE HCl 20.5 BRINE SOLUTION [NaCl] 80 Bromine (Liq) 0.75 Bromo Compound 1.64 Bromo Ester compound 4.25 Bromo Methyl Thiophene 1.14 Calcium Chloride 0.65 Cane Molasses 100 Carbon Disulphide 0.23 Carbon tetrachloride 43.35 Carbonyl Imidazole 0.64 Caustic Flakes 31 Caustic Soda 1.55 Chlorine Gas 1.25 Chloro Compound 1.28 Chloro Sulfonic Acid 7.4 Chloroform 15 Cholic Acid 10 COMU 0.3 Con.HCl 10 Corn Steep Liquor 1000 Cyclo hexane 2.52
Cynoacetamide 12.5 Cysteamin HCl 7.5 D(-) Tartaric Acid 0.64 Di Aza Bi Cyclo Undecane 0.3 Di Iso Propyl Ether 30 Di methoxy ethane 15 DIBAL - H [Diisobutylaluminium hydride]
0.05
Dichloro[1,1′-bis(diphenyl phosphino) ferrocene]palladium
0.1
Diethyl methoxy borane 1 Diisopropylethylamine 1.5 Dimethyl Acetamide 0.28 Dimethyl amine 2 Dimethyl formamide 22 Dipe 45 D-L-Phenylephrine Base 0.5 DMF 43 DMSO 38 EDC HCl 15 Ethanol 20 Ethoxy Ethanol 13.9 Ethyl Acetate 50 Ethyl Chloro Acetate 3 Ethyl Chloro Formate 1.55 Ethyl Ether 2.29 Ethyl Magnesium Bromide 0.58 Ethyl-4-(1-hydroxy-1-methylethyl) 2-propy H-((2-(2-(triphenyllnethyl)-2H-tetrazol-5 yl biphenyl-4-yl-1-methyl imidazole-5-carboxylic acid
0.655
Ethylacetate 18.676 Fmoc 32.5 Formaldehyde 6 HCl GAS 2 HCl SOLN 90 Hexahydrocyclopenta[c]pyrrol-2(1H)-Amine Hydrochloride ( HCl –Compound )
0.7
HMPA [Hexamethylphosphoramide]
5
Hobt 5 Hydrogen fluoride 0.25 Hydrogen Gas 1 Hydroxyl Amine Hydrochloride 0.304 Hyflo 2 Hyflo Super Cel 1 Iodine 1 IPA (Isopropyl Alcohol) 10 Isovaleraldehyde 5 KOH 12 L –Phenylephrine Base 0.5 L(+) tartaric Acid 0.625 l,3-Dibromo-5,5- dimethyl hydantoin
4
L-alanine iso propyl ester HCl 1.72 Lead 0.15 Magnesium Sulphate 27 Mandelic Acid 0.48 Manganese(IV) oxide 1.6 MDC 100 MEK 10.5 Meldrums acid 1.95 Meta chloro peroxybenzoic acid 6 Methane sulfonyl chloride 2.75 Methane sulphonic acid 1.25 Methanol 50 Methanolic HCl 20 % 1.4 Methyl amine 0.5 Methyl Iodide 3 Methyl(3R)-3-(tert butyl di methyl silyloxy)-5-oxo-6-triphenyl phosphoranylidene hexanoate
7.25
Methyl(S)-1-((S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
0.6
Methyl-1 [(2 Cyanobiphenyl4-Yl ]- 2Ethoxybenzenzimidazole-7-Carboxylate.
1.8
methylene chloride 18 Methylene Dichloride 11.43 Mono Ethylene Glycol 3 Mono Methyl Amine 40 % 6 Moxifloxacin Q-Acid 0.85 N,N-Dimethyl formamide 35 N=Methyl Morpholine 6.5 N-Bromo Succinimide 0.5 N-Carbamoyl-4-Methylbenzenesulfonamide (Sulfonamide Compound)
1.05
N-Ethyl -2-Amino Methyl Pyrolidine
1.95
N-HEXANE 32 Nitric Acid 0.4 N-Methyl benzyl Amine 0.35 N-methyl-O-phenylene diamine 1.4 Ortho tolyl benzonitrile 5.4 O-Xylene 48.2 Palladium Charcoal 10 % 0.5 Palladium Hydroxide 0.01 Pd /Ch 4 Pentaflurophenol 3.12 Phenyl dichloro phosphate 2.15 Phenyl Hydrazine 12.25 Piperidine 1.85 Poly phosphoric acid 5.9 Polypeptone 100 Potassium Acetate 0.5 Potassium Butoxide 0.49 Potassium Carbonate 6 Potassium iodide 0.17 P-Toluene Sulphonyl Chloride 0.6 Pyridine 47.5 R-(-)-10-Camphorsulfonic Acid 9 R-(-)-3-Carbamoylmethyl-5-Methylhexanoic Acid (R-CMH)
2.5
R(+) Phenyl Ethyl Amine 1.500 R*(S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
0.67
residue (2S)-1-tert-butyl-2-(3-chloro-8-oxo-8,9,10,11-tetrahydro-6H-naphtho[2,3-c]chromen-9-yl)-4(methoxymethyl)pyrrolidine-1,2-dicarboxylate
0.8
S-(-)-1-Ethyl-2-Amino Methyl Pyrrolidine
0.75
Silica Gel 265 S-Methyl iso thio urea 1.75 Sodium acetate 20.3 Sodium Azide 2.05 Sodium Bicarbonate 14 Sodium Bisulphite 1.5 Sodium boro hydride 1 Sodium carbonate 22 Sodium Hydride 5 Sodium Hydroxide 5 Sodium Iodide 0.052 Sodium Methoxide 10.1 Sodium Sulphate 15 Sodium Triacetoxy Borohydride 5.6 Starch 400 Sucrose 2.5 Sulfuric Acid 10 Sulphur Trioxide Pyridine Complex 14.25 Sulphuric Acid 25 Tartaric Acid 1.5 TBAB 0.45 T-BUTYL ALCOHOL 25 TEA 15 Tert-Butyl magnesium chloride 0.54 Tetrahydrofuran 25 Tetrakis (triphenyl phosphine) palladium
0.1
Tetralone 2 Thionyl chloride 1.6 Toluene 50 Tri Butyl Tin Chloride 10.35 Triethyl Amine 2
Triphenyl phospine 1.38 tris (dibenzylideneacetone) Palladium
0.1
Urea 10 Zinc 1
* We will maintain as minimum inventory as possible.
Enclosure: 4
Material Safety Data Sheets of Products & Raw Materials
(Attached)
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P.O.Box 92 Maalot, 24952 Israel Tel. 972 4 9978 220, Fax. 972 4 9976 062 www.numinor.com
Page 1 of 5
SAFETY DATA SHEET (SDS)
MANGANESE OXIDE
SECTION 1 – IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY Manufacturer & Supplier: NUMINOR CHEMICAL INDUSTRIES LTD. Address: P. O. BOX 92, MAALOT 24952, ISRAEL. Tel: + 972-4-9978220 Fax: + 972-4-9976062 E-Mail: [email protected] Web Site: www.numinor.comEmergency Contact: Mr. Nir Baram, +972 54 587 3131 Chemical Name: Manganese Oxide: (CAS : 1344-43-0 ) ( EINECS: 215-695-8) Formula: MnO Synonyms: Manganous Oxide % Range: 54 - 62% Primary Use: Mineral nutrient additive for the feed industry.
SECTION 2 - HAZARDS IDENTIFICATION Classification according to Regulation (EC) 1272/2008 (GHS-CLP) Acute toxicity: Dermal (Category 3)
Skin Irritation (Category 2) Eye Irritation (Category 2) Specific target organ toxicity-single exposure (Category 3)
GHS Pictogram: Signal Word: Danger Hazard Statements: H311 Toxic in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H335: May cause respiratory irritation.
P.O.Box 92 Maalot, 24952 Israel Tel. 972 4 9978 220, Fax. 972 4 9976 062 www.numinor.com
Precautionary Statements: Page 2 of 5 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/ protective clothing. P305 +P351 +P338 If in eyes: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing. P312 Call a Poison Center or doctor/physician if you feel unwell. Environmental hazard: None Listed.
SECTION 3 – COMPOSITION / INFORMATION ON INGREDIENTS
Melting Point: Not Listed. Specific Gravity: 5.0 Solubility in water: Insoluble Appearance & Odour: Solid powder(fine),Dark brown-Green in colour, no odour.
SECTION 4 - FIRST AID MEASURES Effects and symptoms: Chills, fever, nausea, vomiting, coughing, weakness and headaches,
skin irritation. First aid - Skin contact: Wash immediately with plenty of water and soap/ - Inhalation: Remove victim to fresh air. Clean nasal cavity with water. Give
oxygen if breathing difficulty. Seek medical attention. If feeling unwell, immediately seek medical attention.
- Eye contact: Rinse immediately with clean water for 15 minutes. If feeling unwell, immediately seek medical attention.
- Ingestion: Immediately rinse mouth with water. Do not induce vomiting. Give large quantities of water or milk to drink. If feeling unwell, immediately seek medical attention.
Protection of rescue personnel: Avoid all unnecessary exposure. Use appropriate protection (see Section 9).
SECTION 5 – FIRE, FIGHTING & EXPLOSION DATA Fire: Non Combustible. Flammability: Non Flammable Flash point: Not Combustible Extinguishing media: In case of fire in immediate vicinity use any extinguishing
agent. Protection of fire-fighters: Use breathing apparatus (self-contained breathing apparatus
with full face shield). Wear suitable protective clothing. Hazardous combustion and: None. Decomposition products
P.O.Box 92 Maalot, 24952 Israel Tel. 972 4 9978 220, Fax. 972 4 9976 062 www.numinor.com
Page 3 of 5
SECTION 6 - ACCIDENTAL RELEASE MEASURES & SPILL LEAK PROCEDURES Personal precautions: Wear suitable gloves and eye/face protection. Avoid dust creation. Environmental precautions: Avoid allowing product to enter drains, sewage system, ground
water. Methods for cleaning up: Sweep up and shovel into suitable containers for disposal. Re-
use or recycle waste.
SECTION 7 - HANDLING AND STORAGE Handling & storing: Good housekeeping - store in a cool dry place - keep containers shut. Avoid making dust. Packing Materials: All materials suitable.
SECTION 8 - EXPOSURE CONTROL / PERSONAL PROTECTION - Respiratory protection: Respiratory protection equipment necessary. - Hand protection: Gloves.
Material: leather gloves, cotton gloves, rubber gloves. - Skin protection: Work clothes. - Eye protection: Chemical goggles or safety glasses. Occupational Exposure Limits 8 Hour TLV-TWA [mg/m3] : 0.2 (Dust) Engineering measures: Mechanical ventilation is recommended.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES Melting Point: Not Listed. Density: 5.4 G/cm³ Solubility in water: Insoluble Appearance & Odour: Solid powder(fine), Dark brown - Green in colour, no odour.
SECTION 10 - STABILITY & REACTIVITY DATA Stability: Stable under ordinary conditions Hazardous Reactions: Soluble in mineral acids. Dust explosion if mixed with fine organic
material and exposed to naked flame. Violent reaction with H2O2,
CaOH, and F2.
Incompatibility (materials to avoid): Not Applicable
P.O.Box 92 Maalot, 24952 Israel Tel. 972 4 9978 220, Fax. 972 4 9976 062 www.numinor.com
Page 4 of 5
SECTION 11 – TOXILOGICAL INFORMATION Acute toxicity - Inhalation: Can Cause chills, fever, nausea, vomiting, coughing, weakness and
headaches, - Dermal: Exposure can cause skin irritation.. - Ingestion: (Oral rat) LD50 = 9g/kg Dermal irritation: Can cause irritation. Eyes irritation: Not available. Chronic toxicity: Not available. Sensitization: Not available. Carcinogenicity: Not listed by IARC and ACGIH as carcinogen. Mutagenicity: Not available. Reproductive toxicity: An experimental or tumorigen and mutagen.
Other toxicological information: Eye, skin, respiratory kidney or liver diseases or disorders would be aggravated by repeated or prolonged exposure to this chemical. Persons with history of alcoholism, psychiatric, neurological or liver dysfunction would be expected to be at increased risk from exposure.
SECTION 12 - ECOLOGICAL INFORMATION Persistence and degradability: Not applicable. Bioaccumulative potential: Not applicable. WGK (Germany): 1 Ecotoxicity: Not applicable Mobility: Not applicable.
SECTION 13 - DISPOSAL CONSIDERATIONS Disposal: Comply with local regulations for disposal. Waste of residues: This material and its container should be labeled H. Contaminated packaging: Keep waste packaging separate.
Waste should be disposed of in a permitted chemical waste facility.
SECTION 14 - TRANSPORT INFORMATION Hazard Labels: Not restricted. H.S. Code: 2820.9000 UN - No: Not Listed. ADR/RID/ADNR/IMO-IMDG: Not restricted. Shipping Name: Manganese Oxide
P.O.Box 92 Maalot, 24952 Israel Tel. 972 4 9978 220, Fax. 972 4 9976 062 www.numinor.com
Page 5 of 5 Packaging Group: Not Applicable IMDG-Marine Pollution No EMS No. Not available. MFAG Table Not available.
SECTION 15 – REGULATORY INFORMATION Classification according to Regulation (EC) 1272/2008 (GHS-CLP) Acute toxicity: Dermal (Category 3)
Skin Irritation (Category 2) Eye Irritation (Category 2) Specific target organ toxicity-single exposure (Category 3)
GHS Pictogram: Signal Word: Danger Hazard Statements: H311 Toxic in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H335: May cause respiratory irritation. Precautionary Statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/ protective clothing. P305 +P351 +P338 If in eyes: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing. P312 Call a Poison Center or doctor/physician if you feel unwell.
SECTION 16 - OTHER INFORMATION Date of Issue: August 2010 Last update: August 2010 MSDS prepared by: AVK Disclaimer: As the conditions or methods of use are beyond our control, we do not assume any responsibility and expressly disclaim any liability for any use of the material. Information contained herein is believed to be true and accurate but all statements or suggestions are made without any warranty, express or implied, regarding accuracy of the information, the hazards connected with the use of the material or the results to be obtained from the use thereof.
4-(Hydroxymethyl)phenoxyacetic acid 68858-21-9 MSDS 4-(Hydroxymethyl)phenoxyacetic Acid Revision number: 5 SAFETY DATA SHEET
Section 1. IDENTIFICATION Product name: 4-(Hydroxymethyl)phenoxyacetic Acid Revision number: 5
Section 2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDS Not classified HEALTH HAZARDS Skin corrosion/irritation Category 2 Category 2A Serious eye damage/eye irritation ENVIRONMENTAL HAZARDS Not classified GHS label elements, including precautionary statements Pictograms or hazard symbols Signal word Warning Hazard statements Causes skin irritation Causes serious eye irritation Precautionary statements: Wash hands thoroughly after handling. [Prevention] Wear protective gloves/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, [Response] if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. IF ON SKIN: Gently wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse.
Section 3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture: Substance Components: 4-(Hydroxymethyl)phenoxyacetic Acid Percent: >98.0%(T) CAS Number: 68858-21-9 Chemical Formula: C9H10O4
Section 4. FIRST AID MEASURES Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. 4-(Hydroxymethyl)phenoxyacetic Acid
Section 4. FIRST AID MEASURES Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention. Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth. A rescuer should wear personal protective equipment, such as rubber gloves and air- Protection of first-aiders: tight goggles.
Section 5. FIRE-FIGHTING MEASURES Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide. media: Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protective When extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters:
Section 6. ACCIDENTAL RELEASE MEASURES Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak. protective equipment and Entry to non-involved personnel should be controlled around the leakage area by emergency procedures: roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations.
Section 7. HANDLING AND STORAGE Precautions for safe handling Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any incompatibilities Storage conditions: Keep container tightly closed. Store in a cool and dark place. Store away from incompatible materials such as oxidizing agents. Packaging material: Comply with laws.
Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls: Install a closed system or local exhaust as possible so that workers should not be exposed directly. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator. Follow local and national regulations. Hand protection: Protective gloves. Safety glasses. A face-shield, if the situation requires. Eye protection: Skin and body protection: Protective clothing. Protective boots, if the situation requires.
Section 9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C): Solid Crystal- Powder Form: Colour: Slightly pale yellow - Reddish yellow No data available Odour: pH: No data available Melting point/freezing point:110°C 4-(Hydroxymethyl)phenoxyacetic Acid
Section 9. PHYSICAL AND CHEMICAL PROPERTIES Boiling point/range: No data available Flash point: No data available Flammability or explosive limits: Lower: No data available Upper: No data available Relative density: No data available Solubility(ies): [Water] No data available No data available [Other solvents]
Section 10. STABILITY AND REACTIVITY Chemical stability: Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide products:
Section 11. TOXICOLOGICAL INFORMATION No data available Acute Toxicity: Skin corrosion/irritation: No data available Serious eye No data available damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: No data available IARC = NTP = No data available No data available Reproductive toxicity:
Section 12. ECOLOGICAL INFORMATION Ecotoxicity: Fish: No data available Crustacea: No data available Algae: No data available Persistence / degradability: No data available Bioaccumulative No data available potential(BCF): Mobility in soil Log Pow: No data available Soil adsorption (Koc): No data available Henry's Law No data available constant(PaM3/mol):
Section 13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance.
Section 14. TRANSPORT INFORMATION Hazards Class: Does not correspond to the classification standard of the United Nations UN-No: Not listed 4-(Hydroxymethyl)phenoxyacetic Acid
Section 15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed.
SECTION 16 - ADDITIONAL INFORMATION N/A
www.Lagunaclay.com 800-452-4862 [email protected]
www.Lagunaclay.com 800-452-4862 [email protected]
www.Lagunaclay.com 800-452-4862 [email protected]
www.Lagunaclay.com 800-452-4862 [email protected]
www.Lagunaclay.com 800-452-4862 [email protected]
www.Lagunaclay.com 800-452-4862 [email protected]
MSDS-HCL PAGE 9A-1 Issued 8/5/1999 Revised 10/27/06
Material Safety Data Sheet(MSDS-HCL)
PRODUCT IDENTIFICATION Product Name Hydrochloric Acid Solution 20 Deg. Be – 31.5%
22 Deg. Be – 35.2% Trade Names and Synonyms Hydrogen Chloride (Aqueous)
Muriatic Acid Manufacturer/Distributor Trans Chem, Inc.
1259 Safe Energy Dr. Port Allen, Louisiana 70767 (225) 389-9133 Various others
Transportation Emergency 800-255-3924 (24 hrs -- CHEM • TEL)
HAZARDOUS COMPONENTS Material or Component CAS No. TLV PEL Hydrochloric Acid 7647-01-0 7mg/m3 5PPM N/A = Not assigned NE = Not established
PHYSICAL DATA Boiling Point 127° F Vapor Pressure 24mm Hg – 20 Deg. Be
100mm Hg – 22 Deg. Be Solubility in Water Complete Specific Gravity 1.16 @ 15.5° C 20 Deg. Be
1.1789 @ 15.5° C 22 Deg. Be Melting Point N/A Vapor Density Similar to Water Evaporation Rate Not Applicable Appearance and Odor Clear Colorless to Yellowish Fuming Liquid, Pungent and Irritating
HAZARDOUS REACTIVITY Stable under ordinary conditions of use and storage. Does not polymerize. Incompatible with aluminum and aluminum alloys, carbon steel, copper and copper alloys, and nylon. Hydrogen gas will be formed if acid contacts metal.
FIRE AND EXPLOSION DATA Flashpoint Not Flammable Extinguishing Media Use any means suitable for extinguishing surrounding fire. Decomposition Products Contact with most metals may produce Hydrogen gas to potentially explosive limits. Unusnal Explosion Containers may explode when heated. Consult the 2000 Emergency Response
Guidebook, Guide 157 for further details.
MSDS-HCL PAGE 9A-2 Issued 8/5/1999 Revised 10/27/06
HEALTH HAZARDS / FIRST AID Inhalation Inhalation causes severe irritation of upper respiratory tract. FA: Remove person to to
fresh air. If not breathing, give artificial respiration. Call physician. Ingestion CORROSIVE ! Ingestion of Hydrochloric Acid can cause burns of the mouth, throat,
esophagus and gastrointestinal tract. FA: DO NOT INDUCE VOMITING. Give large quantities of water or milk of magnesia. Never give anything by mouth to an unconscious person. Get immediate medical attention.
Skin Contact CORROSIVE ! Can cause redness, pain and skin burns. Can cause some tissue destruction. FA: Immediately flush with water.
Eye Contact CORROSIVE ! FA: Continuously flush eyes with large amounts of water for at least 20 minutes. If irritation continues, seek medical attention.
SPILL OR LEAK PROCEDURES Spill/leak In the event of a spill or leak, keep upwind. Ventilate enclosed areas until spill or leak is
contained, neutralized and prepared for removal. Waste disposal Disposal of waste material or residue may be subject to federal, state, or local
regulation. Before transporting waste material see 49 CFR 172.
SPECIAL PROTECTION INFORMATION Ventilation Use only in areas with adequate ventilation. Eye Protection Use chemical safety goggles, plus a safety shield is recommended. Contact lenses
should not be worn when working with this material. Skin Protection Wear impervious protective clothing; i.e., Boots, Gloves, Lab Coat, Apron or Coveralls to
prevent skin contact. Other If working in an area of potential exposure, use an NIOSH approved respirator when
material is fuming and exceeds the TLV.
STORAGE CONDITIONS Store and handle only in containers suitably lined with or constructed of materials specified, by the manufacturer, for the product. Protect against physical damage. Keep separated from incompatible materials.
REGULATORY INFORMATION Proper shipping name Hydrochloric acid Hazard class 8 UN Number UN1789 DOT Label & Placard Corrosive NFPA / HMIS Ratings Health – 3; Flammability – 0; Reactivity – 0 SARA Title III Reporting Sections 302, 311 & 313
MSDS-HCL PAGE 9A-3 Issued 8/5/1999 Revised 10/27/06
The information contained in this Material Safety Data Sheet is based upon available data and believed to be correct; however, as such has been obtained from various sources, including the manufacturer and independent laboratories, it is given without warranty or representation that it is complete, accurate, and can be relied upon. OWEN COMPLIANCE SERVICES, INC. has not attempted to conceal in any manner the deleterious aspects of the product listed herein, but makes no warranty as to such. Further, OWEN COMPLIANCE SERVICES, INC. cannot anticipate nor control the many situations in which the product or this information may be used; there is no guarantee that the health and safety precautions suggested will be proper under all conditions. It is the sole responsibility of each user of the product to determine and comply with the requirements of all applicable laws and regulations regarding its use. This information is given solely for the purposes of safety to persons and property. Any other use of this information is expressly prohibited.
For further information contact: David W. Boston, President OWEN COMPLIANCE SERVICES, INC. 12001 County Road 1000 P.O. Box 765 Godley, TX 76044
Telephone number: 817-551-0660 FAX number: 817-396-4584
MSDS prepared by: Allen M. Sweeney Original publication date: 8/5/1999 Revision date 10/27/06
Specification – MPDSA
Product Name : Meta Phenylene Diamine 4 Sulfonic Acid Free Acid
Synonym : 1,3 Diamino Benzene 4 Sulfonic Acid Free Acid
Trade Name : MPDSA
CAS No. : 88-63-1
Molecular Weight : 188 grams/Mole
Empirical Formula : C6 H8 O3 N2 S
Structural Formula : NH2
NH2 SO3H
Purity : Min. 98.00%
Insoluble Content : Max. 00.20%
Moisture : Max. 0.30%
Other impurities : Max. 0.10%
Physical appearance : Light gray White powder
Basis of Sale : On As Is basis
Packing : 25/50kgs HDPE bags with double liners inside
Specification – MPDSA (Sodium Salt)
Product Name : Meta Phenylene Diamine 4 Sulfonic Acid
(Na Salt)
Synonym : 1,3 Diamino Benzene 4 Sulfonic Acid
Trade Name : MPDSA (Na Salt)
Molecular Weight : 210 grams/Mole
Empirical Formula : C6 H8 O3 N2 S
Structural Formula :
NH2
NH2 SO3Na
Purity : Min. 72.00% on MW 188
Insoluble Content : Max. 00.20%
Moisture : Max. 2.00%
Physical appearance : Light Cream powder
Basis of Sale : On 100% basis
Packing : 25/50kgs HDPE bags with double liners inside
Enclosure: 5
Chemical Name and Physical Form of Raw Materials with Its Storage Facility
Raw Material CAS No. Physical form
Container Type Pack Size Maximum Storage
capacity (MT) ( R)-2-(Methoxycarbonylamino)-2- Phenyl acetic Acid
50890-96-5 Solid Fiber Drum 25 0.75
((S)-1-(Tert-Butoxycarbonyl)-4-(Methoxy-Methyl) Pyrrolidine-2-Carboxylic Acid
1378388-16-9 Solid Fiber Drum 25 1.5
(2,4,5-Trifluoro-Phenyl)Aceticacid
209995-38-0 Solid Fiber Drum 25 0.75
(Α,S) 2,4 –Dichloro-A-(Chloromethyl)Benzene- Methanol Methane Sulphonate
53984-39-7 Solid Fiber Drum 25 1.5
1-(3-Methoxyphenyl)Propan-1-One
37951-49-8 Solid Fiber Drum 25 1.5
1,2-Dimethoxyethane 110-71-4 Liquid HDPE Drum 5.5 20
1,4 Dioxane 123-91-1 Liquid HDPE Drum 200 15 1-2,4-Dichloro-Phenyl-2-Imidazole- -1-Yl-Ethanol.
24155-42-8 Solid Fiber Drum 25 3
1h-Imidazole-1-Acetonitrile 18502-05-1 Liquid HDPE Drum 200 0.5 1-Methyl 2-Pyrrodinone 872-50-4 Liquid HDPE Drum 200 20 2,3-Dichloro-5,6-Dicyano Benzoquinone
84-58-2 Solid Fiber Drum 25 1.5
2,6 Dichlorophenol 87-65-0 Solid Fiber Drum 25 1.25 2,8-Diazobicyclo(4.3.0) Nonane 151213-40-0 Liquid HDPE Drum 200 0.5 2-Butyl-4-Chloro-5-Hydroxy-Methyl Imidazole
79047-41-9 Solid Fiber Drum 25 1.25
2-Chloro-2,4-Difluoroacetophenone
51336-94-8 Solid Fiber Drum 25 4.5
2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine
883329-66-2 Solid Fiber Drum 25 1.25
2-Dicyclo Hexylphosphino-2′, 4′, 6′-Tri-I-Opyl-1,1′-Biphenyl
564483-18-7 Solid Fiber Drum 25 0.25
2-Methoxyethanol 109-86-4 Liquid HDPE Drum 200 0.25
2s,4s-4-Hydroxy-L-Prolin 618-27-9 Solid Fiber Drum 25 4.5 3-(Trifluoro Methyl)5,6,7,8-Tetrahydro(4,3-A)Pyrazine HCl
762240-92-6 Solid Fiber Drum 25 1
3,5-Dibromo-1h-1,2,4-Triazole 510758-28-8 Solid HDPE Drums 200 1.5 3-Amino Crotononitrile 1118-61-2 Liquid HDPE Drums 200 3 3-Azido Piperdene Solid Fiber Drum 25 1.5 3-Cyclohexene-1-Methanol 1679-51-2 Liquid HDPE Drum 200 0.5 4-(Chloromethyl)-5-Methyl-1,3-Dioxol-2-One
80841-78-7 Liquid HDPE Drum 200 0.75
4-[2-(Trityltetrazol-5-Yl)Phenyl]Benzyl Bromide
----- Solid PP Bag 50 2.5
4-Amino-2-Ethoxy-5-Nitro-N-(4-Piperidyl) Benzamide
121873-04-9 Solid Fiber Drum 25 0.75
4-Amino-2-Methoxy-5-Ethyl Sulphonyl Benzoic Acid
71675-87-1 Solid Fiber Drum 25 1
4-Bromo Methyl-2-Cyano-Biphenyl
114772-55-3 Solid Fiber Drum 25 1.5
4-Chlorobutyryle Chloride 4635-59-0 Liquid HDPE Drum 200 5 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One
80841-78-7 Solid Fiber Drum 25 0.25
4-Fluoro Benzaldehyde 459-57-4 Liquid HDPE Drum 200 0.75 4-Hydroxymethyl -5-Methyl-1,3-Dioxol-2-One
931-40-8 Solid Fiber Drum 25 0.75
4-Methyl-3-Oxo-Pentanoic Acid Ethyl Ester
7152-15-0 Solid Fiber Drum 25 1
5-Aminobenzofuran-2-Carboxylic Acid
42933-44-8 Solid Fiber Drum 25 3
5-Cyano-Indole 15861-24-2 Solid Fiber Drum 25 2.5 6-Ethyl-5-Fluoropyrimidin-4-Ol 137234-87-8 Solid HDPE Drums 200 2 7-Methyl-2-Propyl-3h-Benzo[D]Imidazole Cooh
152628-03-0 Solid Fiber Drum 25 0.75
9-Bromo-3-Chloro-10,11-Dihydro-5h-Naphtho[C,G]Chromen-8(9h)-One
Not Available Solid Fiber Drum 25 1.5
Acetic Acid 64-19-7 Liquid HDPE Drum 200 15
Acetone 67-64-1 Liquid Tanker 10000 10 Aceto nitrile 75-05-8 Liquid HDPE Drum 200 12
Acetyl Chloride 75-36-5 Liquid HDPE Drum 200 1 Activated Carbon 7440-44-0 Solid Fiber Drum 25 2 Aluminium Chloride 7446-70-0 Solid Fiber Drum 25 1.25 Aluminium Trichloride 7446-70-0 Solid Fiber Drum 25 5 Ammonia 1336-21-6 Gas Cylinder 30 20 Ammonia 30% 1336-21-6 Liquid HDPE Drum 200 1.5 Ammonium Acetate 631-61-8 Solid Fiber Drum 25 0.75 Ammonium Chloride 12125-02-9 Solid Fiber Drum 25 0.5 Ammonium Formate 540-69-2 Solid HDPE Drums 200 12.5 Aniline 62-53-3 Liquid HDPE Drum 25 0.2 Anhydrous Lithium Chloride 7447-41-8 Solid HDPE Drums 200 1.5 Aquous Hbr 10035-10-6 Liquid Glass Bottles 2.5 2 Azo Bis Isobutyronitrile 78-67-1 Liquid Fiber Drum 25 4 Benzene Sulphonyl Chloride 98-09-9 Liquid HDPE Drum 200 0.5 Benzoyl Peroxide 94-36-0 Liquid HDPE Drum 200 0.1 Benzyl Amine 100-46-9 Liquid HDPE Drum 200 2 Bis (Pinacolato) Diboron 73183-34-3 Liquid HDPE Drum 200 1 Bis-(2-Chloroethyl)Amine Hydrochloride
821-48-7 Solid Fiber Drum 25 2.5
Brine Solution [NaCl] 7647-14-5 Solid PP Bag 50 2.5 Bromo Ester Compound ---- Solid Fiber Drum 25 1.5 Bromo Methyl Thiophene 30318-99-1 Solid Fiber Drum 25 2 Butanol 71-36-3 Liquid Tanker 10000 20 Calcium Chloride 10043-52-4 Solid Fiber Drum 50 0.25 Cane Molasses 68990-09-0 Liquid HDPE Drums 200 40 Carbon Disulphide 75-15-0 Liquid HDPE Drum 200 0.5 Carbon Tetrachloride 56-23-5 Liquid HDPE Drum 200 10.25 Carbonyl Imidazole 530-62-1 Solid Fiber Drum 25 1 Caustic Soda 1310-73-2 Solid PP Bag 50 0.75 Chloro Compound --- Solid Fiber Drum 25 2 Chloroform 67-66-3 Liquid HDPE Drums 200 5 Cholic Acid 81-25-4 Solid Fiber Drum 25 5 Comu 1075198-30-9 Solid Fiber Drum 25 0.5 Conc HCl 7647-01-0 Liquid HDPE Drum 200 0.5 Corn Steep Liquor 66071-94-1 Liquid Tanker 10000 60 Cyclohexane 110-82-7 Liquid HDPE Drum 200 3 Cysteamin HCl 156-57-0 Solid Fiber Drum 25 2.5
D(-) Tartaric Acid 87-69-4 Solid Fiber Drum 25 0.75 Di Azo Bi Cyclo Undecane 6674-22-2 Liquid HDPE Drum 200 0.5 Di Iso Propyl Ether 108-20-3 Liquid Tanker 10000 20 Di Methoxy Ethane 110-71-4 Liquid HDPE Drum 200 5 Dibal - H [Diisobutylaluminium Hydride]
1191-15-7 Liquid PP Carboy 2.5 0.015
Dichloro[1,1′-Bis(Diphenyl Phosphino) Ferrocene]Palladium
72287-26-4 Solid Fiber Drum 25 0.25
Diethyl Methoxy Borane 7397-46-8 Liquid HDPE Drum 200 0.5 Di Isopropylethylamine 7087-68-5 Liquid HDPE Drum 200 2.5 Di Methyl Acetamide 127-19-5 Liquid HDPE Drum 200 10 Di Methyl Amine 124-40-3 Liquid HDPE Drum 200 3 Di Methyl Formamide 68-12-2 Liquid HDPE Drum 200 20 DIPE 108-20-3 Liquid HDPE Drums 200 15 DMF 68-12-2 Liquid HDPE Drums 200 12.5 DMSO 67-68-5 Liquid HDPE Drum 200 14 EDC HCl 25952-53-8 Solid Fiber Drum 25 4.5 Ethanol 64-17-5 Liquid HDPE Drum 200 2.5 Ethoxy Ethanol 110-80-5 Liquid HDPE Drum 200 4 Ethyl Acetate 141-78-6 Liquid Tanker 10000 20 Ethyl Chloro Acetate 105-39-5 Liquid HDPE Drum 200 1 Ethyl Chloro Formate 541-41-3 Liquid HDPE Drum 200 0.75 Ethyl Ether 60-29-7 Liquid HDPE Drum 200 3 Ethyl Magnesium Bromide 925-90-6 Liquid HDPE Drum 200 0.75 Ethyl-4-(1-Hydroxy-1-Methylethyl) 2-Propy H-((2-(2-(Triphenyllnethyl)-2h-Tetrazol-5 Yl Biphenyl-4-Yl-1-Methyl Imidazole-5-Carboxylic Acid
144689-24-7 Solid Fiber Drum 25 1
FMOC 28920-43-6 Solid Fiber Drum 25 10 Formaldehyde 50-00-0 Liquid HDPE Drum 200 0.75 HCl Gas 7647-01-0 Gas Cylinder 32 15 HCl Soln 7647-01-0 Liquid Tanker 10000 20 HMPA / [Hexamethylphosphoramide]
680-31-9 Liquid HDPE Drum 200 1.5
HOBT 2592-95-2 Solid Fiber Drum 25 1.5 Hydrazine Hydrate 10217-52-4 Solid Fiber Drum 25 1 Hydrochloric Acid 32% 7647-01-0 Liquid HDPE Drum 200 2.5
Hydrogen Fluoride 7664-39-3 Gas Cylinder 21 0.1 Hydrogen Gas 1333-74-0 Gas Cylinder 7 5 NOS Hydroxyl Amine Hydrochloride 11-1-5470 Solid Fiber Drum 25 0.5 Hyflo 68855-54-9 Solid Paper Bag 10 0.1 Hyflo Super Cel 14464-46-1 Solid Paper Bags 10 0.25 Iodine 7553-56-2 Solid Tanker 10000 12.5 IPA 67-63-0 Liquid Tanker 10000 10 Iso Propyl Alcohol 67-63-0 Liquid Tanker 10000 20 Iso Propyl Ether 108-20-3 Liquid HDPE Drums 200 15 KOH Powder 1310-58-3 Solid PP Bag 50 0.5 L, 2- Cyclo Pentane O Ni Anhydride (Compound-Iii)
474919-59-0 Solid Fiber Drum 25 2
L,3-Dibromo-5,5- Dimethyl Hydantoin
77-48-5 Solid Fiber Drum 25 1.25
L-Alanine Iso Propyl Ester HCl 62062-65-1 Solid Fiber Drum 25 2.5 Lead 7439-92-1 Solid Metal Drums 10 1.5 Magnesium Sulphate 7487-88-9 Solid PP Bag 50 2.5 Mandelic Acid Manganese(Iv) Oxide 1313-13-9. Solid Fiber Drum 25 2.5 MDC 75-09-2 Liquid Tanker 10000 20 MEK 78-93-3 Liquid HDPE Drum 200 5 Meldrums Acid 2033-24-1 Solid Fiber Drum 25 0.75 Meta Chloro Peroxybenzoic Acid 937-14-4 Solid Fiber Drum 25 2 Methane Sulfonyl Chloride 124-63-0 Liquid PP Carboy 30 0.5 Methane Sulphonic Acid 75-75-2 Liquid HDPE Drum 200 0.6 Methane Sulphonyl Chloride 124-63-0 Liquid PP Bag 50 6.5 Methanol 67-56-1 Liquid Tanker 10000 20 Methanolic HCl 20 % 67-56-1 Liquid HDPE Drum 200 1.5 Methyl Amine 74-89-5 Liquid HDPE Drum 200 0.5 Methyl Iodide 74-88-4 Solid Fiber Drum 25 1 Methyl(3r)-3-(Tert Butyl Di Methyl Silyloxy)-5-Oxo-6-Triphenyl Phosphoranylidene Hexanoate
147118-35-2 Solid Fiber Drum 25 2
Methyl(S)-1-((S)-2-(5-Bromo-1h-Imidazol-2-Yl)Pyrrolidin-1-Yl)-3-Methyl-1-Oxobutan-2-Ylcarbamate
1292836-05-5 Solid Fiber Drum 25 1
Methyl-1[(2’cyanobiphenyl4-Yl) Methyl]-2ethoxybenzimidazole -7-Carboxylate
632322-61-3 Solid Fiber Drum 25 2.5
Methylene Chloride 75-09-2 Liquid Tanker 10000 20 Methylene Dichloride 75-09-2 Liquid Tanker 10 20 Mono Methyl Amine 40 % 74-89-5 Liquid HDPE Drum 200 5 Moxifloxacin Q-Acid 86393-33-1 Solid Fiber Drum 25 1.25 N,N-Dimethyl Formamide 68-12-2 Liquid M S Drum 200 5 N,N-Dimethyl Acetamide 127-19-5 Liquid HDPE Drum 200 12.5 N=Methyl Morpholine 109-02-4 Liquid HDPE Drums 200 2 NaCl 7647-14-5 Solid HDPE Drums 200 12.5 NaOH 1310-73-2 Solid PP Bag 50 0.1 N-Bromo Succinimide 128-08-5 Solid Fiber Drum 25 4 N-Ethyl-2-Amino Methyl Pyrrolidine
26116-12-1 Liquid HDPE Drum 200 0.75
N-Hexane 110-54-3 Liquid HDPE Drums 200 12.5 Nitric Acid 7697-36-2 Liquid HDPE Drum 200 1 N-Methyl-O-Phenylene Diamine 4760-34-3 Liquid HDPE Drum 25 0.5 Ortho Tolyl Benzonitrile 100-47-0 Liquid HDPE Drum 200 1.5 O-Xylene 95-47-6 Liquid HDPE Drum 200 15 Palladium Charcoal 10 % 7440-05-3 Solid Metal Drums 10 0.25 Palladium Hydroxide 12135-22-7 Solid M S Drum 20 0.02 Para Toluene Sulphonic Acid 6192-52-5 Solid Fiber Drum 25 0.5 Pd /Ch 7440-05-3 Solid HDPE Drums 200 12.5 Pd/C 5% 5/3/7440 Solid HDPE Drum 10 0.5 Pentaflurophenol 771-61-9 Liquid HDPE Drum 200 4.5 Phenyl Dichloro Phosphate 770-12-7 Liquid HDPE Drum 200 3 Phenyl Hydrazine 59-88-1 Solid Fiber Drum 25 4 Piperidine 110-89-4 Solid Fiber Drum 25 0.75 Poly Phosphoric Acid 8017-16-1 Liquid HDPE Drum 200 1.5 Polypeptone 73049-73-7 Solid Fiber Drum 25 40 Potassium Acetate 127-08-2 Solid Fiber Drum 25 0.75 Potassium Butoxide 865-47-4 Solid Fiber Drum 25 1 Potassium Carbonate 584-08-7 Solid PP Bag 50 0.5 Potassium Iodide 7681-11-0 Solid HDPE Drum 10 0.5 P-Toluene Sulphonyl Chloride 98-59-9 Solid Fiber Drum 25 0.75 R-(-)-10-Camphorsulfonic Acid 35963-20-3 Solid HDPE Drums 200 10
R*(S*)]-6-Fluoro-3,4-Dihydro-2-Oxiranyl-2h-1-Benzopyran
99199-90-3 Solid Fiber Drum 25 1
Residue (2s)-1-Tert-Butyl-2-(3-Chloro-8-Oxo-8,9,10,11-Tetrahydro-6h-Naphtho[2,3-C]Chromen-9-Yl)-4(Methoxymethyl)Pyrrolidine-1,2-Dicarboxylate
Not Available Solid Fiber Drum 25 1.5
Silica Gel 112926-00-8 Solid Fiber Drum 25 25 S-Methyl Iso Thio Urea 867-44-7 Solid Fiber Drum 25 0.5 Sodium Acetate 127-09-3 Solid Fiber Drum 25 15 Sodium Azide 26628-22-8 Solid Fiber Drum 25 0.75 Sodium Bicarbonate 144-55-8 Solid PP Bag 50 3 Sodium Bisulphite 7631-90-5 Solid HDPE Drums 200 3 Sodium Boro Hydride 16940-66-2 Solid HDPE Drum 200 0.5 Sodium Carbonate 497-19-8 Solid PP Bag 50 6.5 Sodium Chloride 7647-14-5 Solid PP Bag 50 10 Sodium Hydride 7646-69-7 Solid Metal Drums 10 1.5 Sodium Iodide 7681-82-5 Solid Fiber Drum 25 0.1 Sodium Methoxide 124-41-4 Solid Fiber Drum 25 3 Sodium Sulphate 7757-82-6 Solid PP Bag 50 3 Sodium Triacetoxy Borohydride 56553-60-7 Solid Fiber Drum 25 2 Starch 9005-25-8 Solid Fiber Drum 25 40 Sulphur Trioxide Pyridine Complex
26412-87-3 Solid Fiber Drum 25 4
Tartaric Acid 87-69-4 Solid Fiber Drum 25 0.75 Tartaric Acid 67-69-4 Solid Fiber Drum 25 1.5 TBAB 1643-19-2 Solid Fiber Drum 25 0.25 T-Butyl Alcohol 75-65-0 Liquid Tanker 10000 20 TEA 121-44-8 Liquid HDPE Drum 200 5 Tert-Butyl Magnesium Chloride 677-22-5 Liquid HDPE Drum 200 1 Tetrahydrofuran 109-99-9 Liquid HDPE Drum 200 10 Tetrakis (Triphenyl Phosphine) Palladium
14221-01-3 Solid Fiber Drum 25 0.25
THF 109-99-9 Liquid HDPE Drums 200 20 Thionyl Chloride 7719-07-9 Liquid PP Carboys 30 0.5 Toluene 108-88-3 Liquid Tanker 10000 20 Toluene Sulfonyl Urea 1694-06-0 Solid Fiber Drum 25 3
Tri Butyl Tin Chloride 1461-22-9 Liquid HDPE Drum 200 3 Triethyl Amine 121-44-8 Liquid HDPE Drums 200 6 Tri phenyl Phospine 603-55-0 Solid Fiber Drum 25 2 Tris (Dibenzylidene acetone) Palladium
32005-36-0 Solid Fiber Drum 25 0.25
Zinc 7440-66-6 Solid Fiber Drum 25 6.5
Enclosure: 7
Details of Hazardous Chemicals
The Raw Materials, which are termed as Hazardous Chemicals as per the "Manufacturing, Storage and Import of Hazardous Chemicals Rules, 1989", are as listed in below:
Name of Hazardous Chemical
Reference The Manufacturer, storage
& Import of Hazardous chemical Rules 1989
Maximum quantity that
can be stored at a time (MT)
Threshold Quantity in
Dioxane Sr. .No. 224 (Part II, Schedule 1 of MSIHCR, 1989 15 No listed
2-Methoxy Ethanol
Sr. .No. 373 (Part II, Schedule 1 of MSIHCR, 1989 0.25 No listed
Acetic Acid Sr. No. 2(Part II, Sch. 1 of MSIHCR, 1989) 15 No listed
Acetone Sr. No. 4 (Part II, Sch. 1 of MSIHCR, 1989) 10 25
Aceto nitrile Sr. No. 7 (Part II, Sch. 1 of MSIHCR, 1989) 12 No listed
Ammonia Sr. No. 31 (Part II, Sch. 1 of MSIHCR, 1989) 20 Not Listed
Aniline Sr. No. 37 (Part II, Sch. 1 of MSIHCR, 1989) 0.2 Not Listed
Hydrogen Bromide
Sr. No. 315 (Part II, Sch. 1 of MSIHCR, 1989) 2 No listed
Azo bis Iso Butyronitrile
Sr. No. 329 (Part II, Sch. 1 of MSIHCR, 1989) 4 No listed
Benzene Sulphonyl Chloride
Sr. No. 57 (Part II, Sch. 1 of MSIHCR, 1989) 0.5
No listed
Benzoyl Peroxide
Sr. No. 66 (Part II, Sch. 1 of MSIHCR, 1989) 0.1 No listed
Carbon Disulphide
Sr. No. 110 (Part II, Sch. 1 of MSIHCR, 1989) 0.5 20
Carbon Tetrachloride
Sr. No. 109 (Part II, Sch. 1 of MSIHCR, 1989) 10.25 No listed
Chloroform Sr. No. 130 (Part II, Sch. 1 of MSIHCR, 1989) 5 No listed
Hydrochloric Acid
Sr. No. 313 (Part II, Sch. 1 of MSIHCR, 1989) 15 No listed
Cyclohexane Sr. No. 161 (Part II, Sch. 1 of MSIHCR, 1989) 3 No listed
Dimethyl Amine Sr. No. 215 (Part II, Sch. 1 of MSIHCR, 1989) 3 No listed
Ethanol Sr. No. 248 (Part II, Sch. 1 of MSIHCR, 1989) 2.5 No listed
Ethyl Acetate Sr. No. 247 (Part II, Sch. 1 of MSIHCR, 1989) 20 No listed
Ethyl Ether Sr. No. 253 (Part II, Sch. 1 of MSIHCR, 1989) 3 No listed
Formaldehyde Sr. No. 37 (Part II, Sch. 1 of MSIHCR, 1989) 0.75 5,50
Hexamethyl Phosphoramide
Sr. No. 304 (Part II, Sch. 1 of MSIHCR, 1989) 1.5 1kg
Hydrogen Fluoride
Sr. No. 317 (Part II, Sch. 1 of MSIHCR, 1989) 0.1 5,50
Hydrogen Gas Sr. No. 314 (Part II, Sch. 1 of MSIHCR, 1989) 5 2,20
Iodine Sr. No. 323 (Part II, Sch. 1 of MSIHCR, 1989) 12.5 No listed
Iso Propyl Alcohol
Sr. No. 334 (Part II, Sch. 1 of MSIHCR, 1989) 20 No listed
Methanol Sr. No. 377 (Part II, Sch. 1 of MSIHCR, 1989) 20 No listed
Methyl Amine Sr. No. 378 (Part II, Sch. 1 of MSIHCR, 1989) 0.5 No listed
Methylene Chloride
Sr. No. 400 (Part II, Sch. 1 of MSIHCR, 1989) 20 No listed
Sodium Hydroxide
Sr. No. 571 (Part II, Sch. 1 of MSIHCR, 1989) 0.1 No listed
N-Hexane Sr. No. 413 (Part II, Sch. 1 of MSIHCR, 1989) 12.5 No listed
Nitric Acid Sr. No. 423 (Part II, Sch. 1 of MSIHCR, 1989) 1 No listed
O-Xylene Sr. No. 442 (Part II, Sch. 1 of MSIHCR, 1989) 15 No listed
Sodium Azide Sr. No. 566 (Part II, Sch. 1 of MSIHCR, 1989) 0.75 No listed
Tert- Butyl Alcohol
Sr. No. 596 (Part II, Sch. 1 of MSIHCR, 1989) 20
No listed
Tetrahydrofuran Sr. No. 602 (Part II, Sch. 1 of MSIHCR, 1989) 10 No listed
Thionyl Chloride Sr. No. 620 (Part II, Sch. 1 of MSIHCR, 1989) 0.5 No listed
Toluene Sr. No. 628 (Part II, Sch. 1 of MSIHCR, 1989) 20 No listed
Triethyl Amine Sr. No. 652 (Part II, Sch. 1 of MSIHCR, 1989)
6 10 Kg
Enclosure: 8
Manufacturing Process and Mass Balance
AMISULPRIDE :
STAGE - I :
INPUT (KG) OUTPUT(KG)
4-amino-2-methoxy-5-ethyl sulphonyl benzoic acid 141
REACTION STEP - I
PRODUCT (Stage - I) 200
N-ethyl-2-amino methyl pyrrolidine 75 Acetone Recover 620
Ethyl chloro format 59 Triethyl amine 80
Waste Water To ETP 946 Acetone 630 Residue 64 Sodium hydroxide soln 20 % 145 Water 700 TOTAL 1830
TOTAL 1830
STAGE - II
STAGE - I 200
REACTION STEP - II
PRODUCT (STAGE - II) 190
Iso Propyl Alcohol 150 Iso Propyl Alcohol Recover 143 Activated Carbon 10
Residue 30 Hyflo Super Cel 3 TOTAL 363 TOTAL 363
STAGE - I
INPUT (Kg)
OUTPUT (Kg)
Methyl-1[(2’Cyanobiphenyl4-yl) methyl]-2Ethoxybenzimidazole -7-carboxylate
90
REACTION STEP - I
Product (Stage I) 85
Hydroxyl amine hydrochloride 15 DMSO Recover 883 Sodium bicarbonate 20
DMSO 900 Residue 32
WATER 900
Waste Water To ETP 925
TOTAL 1925 TOTAL 1925
STAGE - II
STAGE - I
85
REACTION STEP - II
PRODUCT (STAGE - II) 75
TETRAHYDROFURAN 1200 THF Recover 1160 Carbonyl imidazole 32 Di aza bicycle undecane 15 MDC Recover 380
Sodium bisulphite 25
Sodium chloride 20 Methanol Recover 335 Methanol 350 MDC 400 Waste Water To ETP 660 WATER 600
Residue 117
TOTAL 2727
TOTAL 2727
AZILSARTAN MEDOXOMIL:
STAGE - III
STAGE - II
74
REACTION STEP - III
PRODUCT (Stage - III) 50
Sodium hydroxide 7 IPA Recover 352 Hydrochloric acid 12
Isopropyl alcohol 370 Waste Water 920 WATER 900
Residue 41
TOTAL 1363 TOTAL 1363
STAGE - IV :
STAGE - III
50
REACTION STEP - IV
STAGE - IV 57
4-Hydroxymethyl -5-methyl-1,3-dioxol-2-one 20 DMA Rec 266 P-TOLUENE SULPHONYL CHLORIDE 30
Dimethyl Amino Pyridine 3 Water Reuse 840
Dimethyl Acetamide 280
Residue 85 Potassium Carbonate 15
HCl 20% 50 Water 800
TOTAL 1248
TOTAL 1248
STAGE - V
STAGE - IV
57
REACTION STEP - V
Product 50
Ethyl Acetate 180 Ethyl Acetate Recover 171 MDC 200
Activated Carbon 10
MDC Recover 188 Hyflo Super Cel 3
Residue 41
TOTAL 450 TOTAL 450
CINITAPRIDE HYDROGEN TARTRATE
STAGE - I
INPUT (kg)
OUTPUT (kg)
4-Amino-2-ethoxy-5-nitro-N-(4-piperidyl) benzamide
20
REACTION STEP - I
PRODUCT
35
3-Cyclohexene-1-methanol 7 DMF Recover 189 Benzene sulphonyl chloride 11
Sodium Carbonate 3 WASTE WATER 730
TEA 25 Residue 49
Tartaric acid 15
Cyclohexane 88 Cyclohexane Recover 85
DMF 198
Methanol 233 Methanol Recover 225
Activated Carbon 10
Hyflo Super Cel 3
Water 700
TOTAL 1313
TOTAL 1313
GLICLAZIDE
STAGE - I Butanol 200
REACTION STEP-I
PRODUCT (Stage I) 30
Toluene Sulfonylurea 30
Butanol Recover 190 Sodium Carbonate 20
Hydrazine Hydrate 11
Residue 22
Water 300
Waste Water 325 HCl 6
TOTAL 567
TOTAL 567
STAGE - II
Toluene 308
REACTION STEP - II
PRODUCT (STAGE - II) 27.7
p-toluenesulfonic acid 5
Toluene Recover 298 Stage - 1[N _ [(4_ methylphenyl) sulfonyl] - hydrazide carboxamide ] (Compound-IV)
30
l, 2- cyclopentane o ni anhydride (Compound-III)
23
Residue 62.3
Water 400
Water to ETP 440
TOTAL 828
TOTAL 828
STAGE - III
THF
610
REACTION STEP - III
PRODUCT (Stage - III) 18.8
Stage - 2 27.7
THF Recover 595.0 anhydrous lithium chloride 13.85
Vapor Loss 30.0
sodium borohydride 4.43
Water Reuse 433 Water 415.5
Residue 26.68 Activated Charcoal 1.5
Hyflo 0.5
TOTAL 1073.48
TOTAL 1073.48
STAGE - I [DCDPA]
INPUT (Kg)
OUTPUT (Kg)
2,6 Dichlorophenol 0.772
REACTION STEP - I
Product (Stage I) DCDPA 1
Sodium Methoxide 1.82
Ethyl Chloro Acetate Recover 0.513
Ethyl Chloro Acetate 0.54
Residue 1.923 Aniline 0.429
Waste Water To ETP 2.8
Caustic Soda 0.275
Water 2.4
TOTAL 6.236
TOTAL 6.236
STAGE - II [CPDCA]
Stage - I (DCDPA) 1
REACTION STEP - II
Product (Stage - Ii) CPDCA 1 Ethoxy Ethanol 2.5
Ethoxy Ethanol Recover 2.25 Acetyl Chloride 0.55
Residue 0.8
TOTAL 4.05
TOTAL 4.05
INDOLINE :
STAGE -III
Stage - Ii CPDCA 1
REACTION STEP - III
PRODUCT (Stage - III) 0.9
Methanol 5.5
Methanol Recover 5.3 Aluminium Chloride 0.7
Vapor Loss 0.2 Water 3.7
Water reuse 4.5
Activated Carbon 0.05
Hyflo Super Cel 0.02
TOTAL 10.9
TOTAL 10.9
LINAGLIPTIN :
STAGE - I INPUT [kg]
OUTPUT [kg]
Bromo Compound
100
REACTION STEP - I
PRODUCT (Stage I) 122
Chloro Compound 77.8 DMF Recover 588 Potassium carbonate 139.5 Dimethyl formamide 600 Residue 55.3 WATER 800
Waste Water To ETP 952 TOTAL 1717.3 TOTAL 1717.3
STAGE - II
STAGE - I
122
PRODUCT (STAGE - II) 107
3-Azido Piperdene 51 Acetonitrile Recover 176 Potasium Carbonate 112 1-Methyl 2-Pyrrodinone 732 1-Methyl 2-Pyrrodinone 713
Ethyl Acetate 1830
Acetonitrile 183 Ethyl Acetate Recover 1780 Water 1270 Waste Water To ETP 1298 Residue 226 TOTAL 4300 TOTAL 4300
REACTION STEP - II
STAGE - III
Stage - Ii (Azido Compound)
107
REACTION STEP - III
Product (Stage - Iii) 61 Triphenyl Phospine 84.4 Acetonitrile Recover 261 THF 963
MDC 1605 Triphenyl Phospine 27
Acetonitrile 267.5 Triphenyl Phospine OXIDE 57
Water 2107 THF Recover 946 Activated Carbon 10 Waste Water 700 Hyflo Super Cel 3 Water Reuse 1500 Residue 36 MDC Recover 1553
Process Emission N2 6
TOTAL 5147 TOTAL 5147
LOSARTAN : STAGE - I
INPUT (Kg)
OUTPUT (Kg)
2-Butyl-4-Chloro-5-hydroxy-methyl Imidazole
65
REACTION STEP - I
PRODUCT (STAGE - I) 83
Tri Butyl Tin Chloride 172
Toluene Recover 2225 Sodium Azide 34
Sodium Borohydride 9
Methanol Recover 420 Toluene 2300
HCl 25
Waste Water 2400
MEK 174
Residue 418.1 Acetone 435
Spent Carbon [Dry] 7 TBAB 7.2 MEK Recover 165 O-Xylene 800
NaOH 25 Acetone Recover 418 KOH 33.3
Carbon Tetrachloride 720 O-Xylene Recover 775 Ortho Tolyl Benzonitrile 90 L,3-Dibromo-5,5- Dimethyl Hydantoin 66 Carbon Tetrachloride 700 Benzoyl Peroxide 3.6 Water 2210 Activated Carbon 5 Hyflo Super Cel 2 Methanol 435
TOTAL 7611.1
TOTAL 7611.1
LULICONAZOLE :
STAGE - I
INPUT (Kg)
OUTPUT (Kg)
(α,s) 2,4 –dichloro-a-(chloromethyl)benzene- methanol methane sulphonate 100
REACTION STEP - I
Product 100
1H-imidazole-1-acetonitrile 35
Toluene Recover 142 Carbon disulphide 23
KOH powder 18
Waste Water 221 Toluene 150
Residue 31
Water 200 Activated Carbon 10
Water Vapor Loss 45 Hyflo Super Cel 3
TOTAL 539
TOTAL 539
MOXIFLOXACIN :
STAGE - I INPUT (Kg)
OUTPUT (Kg)
Moxifloxacin Q-Acid 100
REACTION STEP - I
PRODUCT 78
2,8-Diazobicyclo(4.3.0) nonane 29
Acetonitrile Recover 480
Acetonitrile 500
Residue 164
Triethyl amine 5
Waste Water 600
Methanol 650
Methanol Recover 625
HCl 90
Liquor Ammonia 60
Activated Carbon 10
Hyflo Super Cel 3
Water 500
TOTAL 1947
TOTAL 1947
NEBIVOLOL :
STAGE - I :
INPUT (KG) OUTPUT(KG)
REACTION STEP - I
PRODUCT (Stage - I) 17
R*(S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
15 Iso Propyl Alcohol Recover 250
Benzyl amine 24.8 Iso Propyl Alcohol 265
Waste Water To ETP 0 Benzyl Amine Rec 18 Residue 19.8 TOTAL 304.8
TOTAL 304.8
STAGE - II
STAGE - I 17
REACTION STEP - II
PRODUCT (STAGE - II) 22.5 R*R*)-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 13.6
Palladium Charcoal 10 % 11.3 Methanol Recover 260 Ammonium Formate 14.2 Residue 73 Methanol 271
Pd / Ch Recover 10.9 Iso Propyl Alcohol 255 Iso Propyl Alcohol Recover 245 Activated Carbon 1.7 Hyflo Super Cel 0.6
Conc HCl 7 TOTAL 591.4 TOTAL 591.4
OLMESARTAN MEDOXOMIL:
STAGE - I A + I B
INPUT (Kg)
OUTPUT (Kg)
Ethyl-4-(1-hydroxy-1-methylethyl) 2-propy H-((2-(2-(triphenyllnethyl)-2H-tetrazol-5 yl biphenyl-4-yl-1-methyl imidazole-5-carboxylic acid (Imidazole Ethyl Ester Derivative)
100
REACTION STEP - I
PRODUCT (Stage I) 272
4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide
227.5
Ethyl Acetate Recover 2600
Potassium Carbonate 72
N,N-Dimethylacetamide 1104 Residue 374.7
Acetone 700
Waste Water To ETP 4050.7
Water 3387
DIPE Recover 1273 THF 1608 Ethanol 268
THF Recover 1561.8
NaOH 15.72
4-(chloro methyl ) -5-methyl-1,3-dioxol-2-one 68
Acetone Recover 665
Sodium Iodide 8
Ethyl Acetate 2680
DMA Recover 1049 Nacl 268
Di Iso Propyl Ether 1340
TOTAL 11846.22 TOTAL 11846.2
STAGE - II A + II B
STAGE - I
272
REACTION STEP - II
PRODUCT (STAGE - II) 152.6 Acetone 4313
Acetone Recover 4200
Sodium Bicarbonate 6.7 Activated Carbon 17 MDC Recover 2600
Hyflo Super Cel 3
Waste Water 1720 Ethyl Acetate 170
Water reuse 2000 Water 3707
Methylene Chloride 2721
Acetic Acid Recover 1590 Acetic acid 1671
Residue 618.1
TOTAL 12880.7
TOTAL 13380.7
ROSUVASTATIN CALCIUM:
STAGE - I
4-Fluoro Benzaldehyde 52
REACTION STEP - I
PRODUCT (Stage I) 100
4-Methyl-3-oxo-pentanoic acid ethyl ester 66.3
Methanol Recover 237 KOH 30
Methyl Iodide 60
Waste Water To ETP 590.5 Methanol 250
Organic Residue 31.3
Water 500
TOTAL 958.3
TOTAL 958.8
STAGE - II
STAGE - I 100
REACTION STEP - II
PRODUCT (STAGE - II) 115
S-Methyl iso thio urea 35
MDC Recover 474 2,3-Dichloro-5,6-dicyano Benzoquinone 85
HMPA 100
HMPA Recover 94 MDC 500
WATER 300
Waste Water To ETP 310
Residue 45
2,3-Dichloro-5,6-dicyano Benzoquinone 82
TOTAL 1120
TOTAL 1120
STAGE – III
STAGE - II 115
REACTION STEP - III
PRODUCT (Stage - III) 120
Meta chloro peroxybenzoic acid 118.68
Waste Water 500.5 MDC 300
MDC Recover 285 Water 500
Meta Chloro Benzoic Acid 108
Organic Residue 20.2
TOTAL 1033.7
TOTAL 1033.7
STAGE - IV :
STAGE - III 120
RECTION STEP - IV
PRODUCT (STAGE - IV) 96
Methyl amine 10.2
Methanol Recover 285 Ethanol 250
Residue 4.2 Methanol 300
Waste Water To ETP 327
Water 300
Ethanol Recover 238
TOTAL 980.2
TOTAL 980.2
STAGE - V :
STAGE - IV 96
REACTION STEP - V
PRODUCT (STAGE - V) 112
Methane sulfonyl chloride 35
Di methoxy ethane Recover
285
Sodium hydride (60%) 1
Di methoxy ethane 300
HCl Gas Emission 11
Organic Residue 24
TOTAL 432
TOTAL 432
STAGE - VI :
STAGE - V 112
REACTION STEP - VI
PRODUCT (STAGE - VI) 95
Hydrogen Gas 0.56
Toluene Recover 284
Dibal - H 1
Toluene 300
Organic Residue 34.56
TOTAL 413.56
TOTAL 413.56
STAGE - VII :
STAGE - VI 95
REACTION STEP - VII
PRODUCT (STAGE - VII) 155
Methyl(3R)-3-(tert butyl di methyl silyloxy)-5-oxo-6-triphenyl phosphoranylidene hexanoate
144.5
By Product - Triphenyl Phosphine (Reuse In Process) 75.2
Triethyl amine 15
DMF Recover 280 N,N-Dimethyl formamide 300
WATER 200
Organic Residue 24.3
Waste Water 220
TOTAL 754.5
TOTAL 754.5
STAGE - VIII :
STAGE - VII 155
REACTION STEP - VIII
PRODUCT (STAGE - VIII) 120
Hydrogen fluoride 5.1
THF Recover 237 THF 250
Ethyl Acetate 300
Ethyl Acetate Recover 285
Organic Residue 33.86
By Product - Tert-Butyl-Fluoro-Dimethyl Silane (Reuse In Process)
34.24
TOTAL 710.1
TOTAL 710.1
STAGE - IX :
STAGE - VIII 120
REACTION STEP - IX
PRODUCT (STAGE - IX) 115
HYDROGEN GAS 0.48
THF Recover 480 Diethyl methoxy borane 20
Sodium boro hydride 1
Ethyl Acetate Recover 240 Ethyl acetate 250
THF 500
Residue 56.48
TOTAL 891.48
TOTAL 891.48
STAGE - X : (ROSUVASTATIN CALCIUM)
STAGE - IX
115
REACTION STEP - X
PRODUCT (STAGE - IX) 100
Calcium Chloride 13
Toluene Recover 478 Toluene 500
Ethyl Acetate 500
Ethyl Acetate Recover 483 Water 250
Activated Carbon 10
Residue 67 Hyflo Super Cel 3
Water reuse 263
TOTAL 1391
TOTAL 1391
SERTACONAZOLE NITRATE : STAGE - I 1-2,4-Dichloro-Phenyl-2-Imidazole -1-Yl-Ethanol.
5
REACTION STEP-I
PRODUCT (Stage I) 3.85
Tartaric Acid 3.2 Methanol/ Acetone Recover 59 Acetone 38
Vapor Loss 3 Methanol 24 Organic Residue 4.35 TOTAL 70.2 TOTAL 70.2 STAGE – II STAGE – I 3.85
REACTION STEP – II
PRODUCT (STAGE – II) 3.5 Potassium Butoxide 1.72 DMF Recover 22 DMF 24 Bromo Methyl Thiophene 4 MDC Recover 36 MDC 40
Water 50 Ethyl Ether 7.2 Ethyl Ether 8 Waste Water To ETP 53 Residue 9.9 TOTAL 131.6 TOTAL 131.6
STAGE – III
STAGE – II 3.5
REACTION STEP – III
PRODUCT (Stage – III) 3.5
Ethanol 18
Ethanol Recover 17 Water 16
Nitric Acid 1.4
Waste Water to ETP 17.4 Activated Carbon 1
Spent Carbon 2.5
Hyflo Super Cel 0.5
TOTAL 40.4
TOTAL 40.4
SERTACONAZOLE NITRATE :
STAGE - I
1-2,4-DICHLORO-PHENYL-2-IMIDAZOLE -1-YL-ETHANOL.
5
REACTION STEP-I
PRODUCT (Stage I) 3.85
TARTARIC ACID 3.2
METHANOL/ ACETONE REC 59
ACETONE 38
VAPOR LOSS 3
METHANOL 24
ORGANIC RESIDUE 4.35
TOTAL 70.2
TOTAL 70.2
STAGE - II
STAGE - I
3.85
REACTION STEP -
II
PRODUCT (STAGE - II) 3.5
POTASSIUM BUTOXIDE
1.72
DMF REC 22
DMF 24
VAPOR LOSS 2
BROMO METHYL THIOPHENE 4
MDC REC 36
MDC
40
VAPOR LOSS 4
WATER
60
ETHYL ETHER 7.2 ETHYL ETHER 8
VAPOR LOSS 0.8
WASTE WATER TO ETP 63
ORGANIC RESIDUE 3.1
TOTAL 141.6
TOTAL 141.6
SERTRALINE HCl
STAGE - I :
INPUT (KG) OUTPUT(KG)
Water 250
REACTION STEP - I
PRODUCT (Stage - I) 52
Tetralone 50 Methanol Recover 95
Mono Methyl Amine 40 % 150
Methanol 100 Waste Water To ETP 298 Residue 105 TOTAL 550
TOTAL 550
STAGE - IIA
STAGE - I 52
REACTION STEP - II
PRODUCT (STAGE - II) 40
Methanol 390 Methanol Recover 387 Palladium Charcoal 10 % 1.04
Hydrogen Gas 14
Pd / Ch Recover 1.04 Methanolic HCl 20 % 35
Gas Emission 12 Activated Carbon 5.2 Hyflo Super Cel 1.6
Residue 58.8
TOTAL 498.84 TOTAL 498.84
STAGE - IIB
STAGE -2A 40
REACTION STEP - III
PRODUCT (STAGE - III) 19
Ethyl Acetate 180 Ethyl Acetate Recover 171 NaOH 18
Mandelic Acid 12
Methanol Recover 95 Methanol 100
Organic Residue 47 Waste Water 18 TOTAL 350 TOTAL 350
STAGE - III
STAGE -2B 19
REACTION STEP - III
PRODUCT (STAGE - III) 25
Aceto nitrile 180 Aceto nitrile Rec. 172 HCl Gas 9
Residue 11 TOTAL 208 TOTAL 208
SITAGLIPTIN :
STAGE – I
INPUT [kg]
OUTPUT [kg]
(2,4,5-Trifluoro-phenyl)aceticacid 20
REACTION STEP - I
PRODUCT (Stage I) 34 Thionyl chloride 12.5 MDC Recover 775 DMF 7
MDC 800
TEA Recover 105 TEA 110
Meldrums acid 15.5 Residue 32.3 Sodium hydroxide 13 Waste Water To ETP 265 WATER 240 SO2 Gas Emission 6.7 TOTAL 1218 TOTAL 1218
STAGE - II
STAGE - I
34
REACTION STEP - II
PRODUCT (STAGE - II) 40
3-(Trifluoro methyl)5,6,7,8-tetrahydro(4,3-a)pyrazine HCl
23 Acetonitrile Recover 162
Methane sulphonic acid 10
Ammonia 1.7
Sodium bicarbonate 8.5
Ethyl Acetate Recover 238
Ethyl acetate 250
Acetonitrile 170 Waste Water To ETP 367.5
Water 340
Activated Carbon 10 Residue 33.6
Hyflo Super Cel 3 Process Emission 8.9
TOTAL 850
TOTAL 850
SOFOSBUVIR :
STAGE - IA
INPUT [kg]
OUTPUT [kg]
L-alanine iso propyl ester HCl
232
REACTION STEP - I
PRODUCT (Stage I) 558
Phenyl dichloro phosphate 290 MDC Recover 5904 Triethyl amine 435 Methylene chloride 6137
TEA HCl Recover 406 Pentaflurophenol 421 Water 4080 Organic Residue 142 Waste Water To ETP 4200
Pentaflurophenol Recover 385
TOTAL 11595 TOTAL 11595
STAGE - IB Stage - IA 558
REACTION STEP - II
PRODUCT (STAGE IB) 174
Di isopropyl ether 2760 Di isopropyl ether
Recover 2650
Residue 494 TOTAL 3318 TOTAL 3318
STAGE - II
STAGE - I
174
REACTION STEP - III
PRODUCT (STAGE - II) 135
2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine 100 THF Recover 2588 THF 2690
Tert-Butyl magnesium chloride 72.7 Ethyl Acetate Recover 1728 HCl 32 % 184.4
WATER 5644 Waste Water 3000 ETHYL ACETATE 1800 Water Reuse 3000 Sodium carbonate 40
Sodium Chloride 400 Process Emission Butane 36 MDC 3432 MDC Recover 3295 Activated Carbon 10
Hyflo Super Cel 3 Di Isopropyl Ether Recover 278 Diisopropylether 290 Residue 711 Penta Fluorophenol Recover 69
TOTAL 14840
TOTAL 14840
TAPENTADOL HCl
STAGE - I
1-(3-Methoxyphenyl)propan-1-one
40
REACTION STEP - 1
PRODUCT 50
Dimethyl Amine 100
Ethyl Acetate Recover 285 Formaldehyde 20
Ethyl Magnesium Bromide 29
Waste Water 150 D(-) Tartaric Acid 32
Residue 151.9
HCl 7.5 Palladium Hydroxide 0.5
IPA Recover 185 Hydrogen Gas 0.4
IPA 200
PROCESS EMISSION [HBr] 20 Ethyl Acetate 300
Water 100
Palladium Hydroxide 0.5 Activated Carbon 10
Hyflo Super Cel 3
TOTAL 842.4
TOTAL 842.4
TELMISARTAN :
STAGE - I
INPUT (Kg)
OUTPUT (Kg)
7-methyl-2-propyl-3H-benzo[d]imidazole COOH
1.43
REACTION STEP - I
PRODUCT
3.03
N-methyl-O-phenylene diamine 0.84 Toluene 4.29 Toluene Recover 4.07
Poly phosphoric acid 3.57
Residue 3.22
Bromo Ester compound 2.58 Waste Water With H3PO4 6
Water 4.29 Distillation Residue 0.81
Activated Carbon 0.1
Hyflo Super Cel 0.03
TOTAL 17.13
TOTAL 17.13
TENELIGLIPTIN HYDROBROMIDE STAGE - I
CYSTEAMIN HCl 1.5
REACTION STEP-I
Product (Stage I) 1.15
Formaldehyde 1.05
MDC Recover 7.3 MDC 7.5
Sodium Carbonate 2.5
Residue 2.6
Sodium Sulphate 1.5
Waste Water 12.5 Water 9.5
Total 23.55
Total 23.55
STAGE – II 2S,4S-4-hydroxy-L-prolin 3.1
REACTION STEP – II
Product (Stage – Ii) 4.6
THF 7.5
THF Recover 7.2
Sodium Bicarbonate 1.5
FMOC 6.5
DIPE Recover 1.4 Water 8.5
DIPE 1.5
Waste Water To ETP 11.5 1 N HCl SOLN 3.5
Residue 7.4
TOTAL 32.1
Total 32.1
STAGE - III
STAGE - II
4.6
REACTION STEP - III
PRODUCT (Stage - III) 2.53 MDC 8.5
MDC Recover 8.1
HOBT 1 N=Methyl Morpholine 1.3
DIPE Recover 7.2 Stage - I 1.15
EDC HCl 3
Ethyl Acetate Recover 6.3 NaOH 0.25
DIPE 7.5
IPA Recover 7.2 Ethyl Acetate 6.5
HCl Solution 50% 2
Waste Water 8.85 Water 5.6
Residue 8.72
Iso Propyl Alcohol 7.5
TOTAL 48.9
TOTAL 48.9
STAGE - IV
STAGE - III 2.53
REACTION STEP – IV
PRODUCT (STAGE – IV) 1.5
Triethyl Amine 3.5
TEA Recover 3.3 MDC 10
DMSO 7.5
MDC Recover 9.6 Sulphur Trioxide Pyridine Complex 2.85
HCl 7
DMSO Recover 7.1 Na2CO3 0.5
Na2SO4 0.25 Acetone 1.65
Residue 12.85
Acetone Recover 1.45
TOTAL 35.8
TOTAL 35.8
STAGE -V
3-Amino Crotononitrile
2
REACTION STEP - V
PRODUCT (Stage - V) 3.7
HCl 2
Waste Water 5.8 Phenyl Hydrazine 2.45
NaHCO3 0.05
Water 3
TOTAL 9.5
TOTAL 9.5
STAGE -VI
BIS 2-CHLORO ETHYL AMINE HCl
4
REACTION STEP - VI
PRODUCT (Stage - VI) 1.23
DMF 7.5
DMF Recover 7.1 Sodium Hydride 1
Stage - V 3.7
MDC Recovery 2.3 KOH 1.85
MDC 2.5
Toluene Recover 7.50 Toluene 8
Acetic Acid 3.7
Residue 10.47 Activated Carbon 0.04
Waste Water reuse 7.2
Hyflo 0.01 Water 3.5
TOTAL 35.80
TOTAL 35.80
URSODEOXYCHOLIC ACID
STAGE - I Methanol 1200
REACTION STEP-I
Product (Stage I) 837
Cholic Acid 750
Ethyl Acetate Recover 1305 HCl 7.5
Sodium Acetate 10
Methanol Recover 1140 Toulene 1250
Dimethyl Amino Pyridine 22.5
Residue 320 Ethyl Acetate 1375
Toluene Recover 1185
Water 450 Acetic Anhydride 190
Waste Water 468
TOTAL 5255
TOTAL 5255
.
STAGE - II
Ethyl Acetate 1125
REACTION STEP-II
Product (Stage Ii) 792
Stage - I 837
Ethyl Acetate Recover 1070 Acetic Acid 75
Sodium Hypochlorite 750
Methanol Recover 1140 Methanol 1200
Organic Residue 760
Waste Water 225
TOTAL 3987
Total 3987
STAGE - III
Triethylene Glycol 1320
REACTION STEP-III
PRODUCT (Stage Iii) 585
Stage - Ii 792
Waste Water 3000 KOH 354
Triethylene Glycol Recover 1255
Hydrazine Hydrate 67 Sulphuric Acid 310
Residue 519 Water 2510
Chenodeoxycholate 6
TOTAL 5359
TOTAL 5359
STAGE - IV
Butanol 864
REACTION STEP-IV
Product (Stage Iv) 526 Methylene Chloride 672
Waste Water 585
Stage - Iii 585
Butanol Recover 820 Sulphuric Acid 37
Sodium Bromide 92
Residue 619 Water 300
TOTAL 2550
TOTAL 2550
STAGE - V Butanol 1570
REACTION STEP-V
Product (Stage - V) 589
Stage - Iv 26
Butanol Recover 1500 Sodium Metal 46
Phosphoric Acid 156
Ethyl Acetate Recover 2020 Imidazole 97
Residue 180
Ethyl Acetate 2130
Waste Water 986 Water 750
Total 5275
Total 5275 Stage - Vi
Butanol 450
REACTION STEP-VI
Product (Stage - Vi) 520 Stage - V 589
Butanol Recover 420
D M Stage – 5 Phosphoric Acid
450
Phosphoric Acid 90
Ethyl Acetate Recover 850 Methanol 810
HCl 9
Waste Water 200 Ethyl Acetate 900
Methanol Recover 770
Residue 538
Total 3298
Total 3298
Stage – Vii
D M Water 1200
REACTION STEP-VII
Product (Stage – Vii) 465 Stage – Vi 520
Ethyl Acetate Recover 855
NaOH 193.8 Ethyl Acetate 900
Water reuse 1618 Acetic Acid 97.2
Residue 100
Phosphoric Acid 97
Activated Carbon 24
Hyflo 6
Total 3038
TOTAL 3038
VORICONAZOLE STAGE - I THF 300
REACTION STEP-I
PRODUCT (Stage I) 64
3,5-dibromo-1H-1,2,4-triazole
43.7
THF REC 285
2-chloro-2,4-difluoroacetophenone 40.4
VAPOR LOSS 15
POTASSIUM CARBONATE 36.3
IPA REC 211
IPA
219
VAPOR LOSS 8
WATER 44
ORGANIC RESIDUE 20.4
WASTE WATER 80
TOTAL 683.4
TOTAL 683.4 STAGE - II
MDC
300
REACTION STEP - II
PRODUCT (STAGE - II) 46
6-ethyl-5-fluoropyrimidin-4-ol
30
MDC REC 285 TEA 59
VAPOR LOSS 15
METHANE SULPHONYL CHLORIDE 18
WASTE WATER TO ETP 174.8
ACETIC ACID
37.8
ORGANIC RESIDUE 2
MAGNESIUM SULPHATE
18
WATER 60
TOTAL 522.8
TOTAL 522.8
STAGE - III
STAGE - II
46
REACTION STEP - III
PRODUCT (Stage - III) 65
MDC 30
MDC REC 27 N-BROMO SUCCINIMIDE 55.8
VAPOR LOSS 3
Azo bis IsoButyronitrile 1.71
WASTE WATER 152
SODIUM BISULPHITE 19.86
ORGANIC RESIDUE 38.37 SODIUM BICARBONATE 15
MAGNESIUM SULPHATE 27
WATER 90
TOTAL 285.37
TOTAL 285.37
STAGE - IV
STAGE - III
65
REACTION STEP - IV
PRODUCT (STAGE - IV) 75.5
THF 640
THF REC 608 MDC 1200
VAPOR LOSS 32
STAGE - I 64
MDC REC 1140
ZINC 44
VAPOR LOSS 60
LEAD 3.5
ETHYL ACETATE REC 190 IODINE 21.3
VAPOR LOSS 10
HCL 23.5
WASTE WATER TO ETP 444
NaCl 57.7
ORGANIC RESIDUE 53.5 MgSO4 70
n-HEXANE REC 182
ETHYL ACETATE 200
VAPOR LOSS 10 n-HEXANE 192
WATER 224
TOTAL 2805
TOTAL 2805
STAGE -V
STAGE - 4
75.5
REACTION STEP - III
PRODUCT (Stage - V) 40.5
TOLUENE
200
WASTE WATER 220 Pd /Ch 22.6
TOLUENE REC 190
AMMONIUM FORMATE 124.6
VAPOR LOSS 10
ISO PROPYL ETHER 180
ISO PROPYL ETHER 171
MAGNESIUM SULPHATE 21
VAPOR LOSS 9 WATER 75
REC Pd /Ch 22.6
ORGANIC RESIDUE 35.6 TOTAL 698.7
TOTAL 698.7
STAGE -VI
ACETONE
125
REACTION STEP - III
PRODUCT (Stage - VI) 27
STAGE - 5 40.5
ACETONE REC 119 R-(-)-10-camphorsulfonic acid 54
VAPOR LOSS 6
ORGANIC RESIDUE 67.5
TOTAL 219.5
TOTAL 219.5
STAGE -VII
MDC
270
REACTION STEP - III
PRODUCT (Stage - VII) 6
SODIUM BICARBONATE 108
MDC RECOVERY 257
STAGE - VI 27
VAPOR LOSS 13 MAGNESIUM SULPHATE 24
IPA REC 25.4
CARBON 1.35
VAPOR LOSS 1.4 HYFLO 0.54
ORGANIC RESIDUE 21
IPA 27
WASTE WATER 213
ISO PROPYL ETHER 135
DIPE REC 128
WATER 80
VAPOR LOSS 7
SPENT CARBON 1.09
TOTAL 672.89
TOTAL 672.89
3-[1-Hydroxy-2-(Methylamino)ethyl]phenol
(D,L- Phenylephrine Base)
PROCESS FLOW DIAGRAM
Stage-1:- Bromo compound
3-Hydroxy Acetophenone + Ethyl acetate
AIBN +Alcl3 + Bromine (Liq)
GLR Reactor
Water addition & layer separation
Ethyl Acetate layer Charging GLR Reactor
N-methyl benzyl amine addition GLR Reactor
Water addition and workup GLR Reactor
Toluene and HCl addition then Layer separation GLR Reactor
Product Isolation + temp 40 to 45° Maintaining GLR Reactor
Washing Centrifuge& Drying
Bromo- Compound
Stage-2 :-D-L Phenylephrine Base
Bromo compound
S.S Reactor
Methanol solvent + Acetic Acid + 10 % PDC
Nitrogen gas + Hydrogen gas
Temp 50 to 55 ° + 24hrs. Maintain
S.S Reactor
Filter 10 % PDC
Water addition and Charcoal treatment S.S Reactor
Methanol reuse & Recycle
PH adjustment S.S Reactor
Filtration and washing Centrifuge, Drying
D-L
Phenylephrine Base
N-(Hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-Methylbenzenesulfonamide
(Gliclazide)
Stage – 1 :Gliclazide –crude
Hexahydrocyclopenta[c]pyrrol-2(1H)-Amine Hydrochloride
N-Carbamoyl-4-Methylbenzenesulfonamide
S.S. Reactor
Toluene + SodiumMethoxide
Reflux Temp S.S. Reactor
Centrifuging
Drying
Gliclazide Crude
PROCESS FLOW DIAGRAM
Stage -2 : Gliclazide
Gliclazide Crude
G.L. Reactor
MDC solvent
Activated Charcoal Sparkler Filter
MDC Recovery
Methanol Centrifuging ML for Reuse
Drying
Milling, Shifting & Packing
Gliclazide
N-[[(2S)-(-)-1-Ethylpyrrolidin-2-yl]-2-Methoxy-5-Sulfamoylbenzamide
(Levosulpiride)
PROCESS FLOW DIAGRAM
Stage -1 : Levosulpiride -Crude
2-Methoxy-5-Sulfamoyl Benzoic Acid Methyl Ester.
S-(-)-1-Ethyl-2-Amino Methyl Pyrrolidine
S.S. Reactor
Mono Ethylene Glycol
Temp 50 to 55° S.S. Reactor
Cool 30 to 35° S.S. Reactor
Centrifuge
Drying
Levosulpiride
Crude
Stage-2 :Levosulpiride
Levosulpiride -crude
Methanol
GLR Reactor
Temp 60 To 65 °c
Activated carbon Sparkler Filter
GLR Reactor
Methanol Washing Centrifuge ML for reuse and recycle
Drying
Milling, Shifting & packing
Levosulpiride
3-[(1S)-1-Hydroxy-2-(Methylamino)Ethyl]Phenol
(L- Phenylephrine Base)
PROCESS FLOW DIAGRAM
Stage-1 :- L- Phenylephrine Base
IPA +Water + L(+) tartaric Acid
D-L Phenylephrine Base
S.S. Reactor
Temp 40 to 45 °
Filtration
Centrifuge ML for L-base Isolation
Wet cake Charging + Caustic Flakes addition and Solid isolation
S.S Reactor
Centrifuge MLRecycle and Reuse.
Drying
Acetic anhydride + Sulfuric acid and Heating 80 to 85° temp
GLR Reactor Acetic Acid Distilled out
CF ML from D,L –Base Resolution Stage.
Water + PH adjustment with Caustic Flakes
S.S. Reactor
Filtration
Centrifuge ML for Recycle and Reuse.
Drying
L-
Phenylephrine Base
PH adjust with Caustic Solution
GLR Reactor
Centrifuge &Drying
L-
Phenylephrine Base
L- Phenylephrine Base (Resolution )
3-[(1S)-1-Hydroxy-2-(Methylamino)ethyl]phenol Hydrochloride(Phenylephrine HCL)
PROCESS FLOW DIAGRAM
Stage-1 : Phenylephrine HCl
L-Phenylephrine Base
IPA and HCL Gas
GLR Reactor
Temp 60 To 65 °c
Activated carbon Sparkler Filter
GLR Reactor
IPA Washing Centrifuge ML for reuse and recycle
Drying
Milling, Shifting & packing
Phenylephrine HCl
(3S)-3-(Aminomethyl)-5-Methylhexanoic Acid
(PREGABALIN)
PROCESS FLOW DIAGRAM
STAGE :(3S)-3-(Aminomethyl)-5-Methylhexanoic Acid (PREGABALIN)
R-CMH + Water
Caustic Flakes
S.S Reactor
Chlorine Gas
Temp 60° to 65° and Adjust PH S.S Reactor
Centrifuge
IPA+Water
Charcoal Treatment GLR Reactor
Isolation GLR Reactor
Centrifuge
CF ML for Reuse and Recycle
Drying , Milling & Shifting
Packing
( PREGABALIN )
(+/-)-3-( Carbamoylmethyl )-5-Methylhexanoic Acid (CMH)
PROCESS FLOW DIAGRAM
STAGE-1 :(+/-) 3-(Carbamoylmethyl)-5-Methylhexanoic Acid ( CMH)
Isovaleraldehyde
Cynoacetamide + Water
GLR Reactor
Sulfuric Acid
Heat Temp 70 to 80° GLR Reactor
Toluene Charging GLR Reactor
Urea Charging and temp 130 to 140° GLR Reactor Toluene for Distillation
PH adjustment, Maintaining& Charcoal treatment GLR Reactor
PH adjustment and Isolation GLR Reactor
Centrifuge
Drying & Packing
CMH
(Sucralfate)
PROCESS FLOW DIAGRAM
Stage -1 : Sucralfate
Pyridine GLR Reactor
Chlorosulfonic Acid
Sucrose
GLR Reactor
Ammonia Solution + Methanol
Methanol washing Centrifuge
Wet Cake Charging + Water S.S Reactor
Activated Carbon + Hyflow Filter
Charging Filtrate
S.S Reactor
Aluminum Hydroxy Chloride
Centrifuge
Water Washing
Drying
Milling & Shifting
Sucralfate
Enclosure: 9 Details of Water Consumption and Waste Water Generation
Application Water Consumption
(KL/Day) Waste Water Generation
(KL/Day) Domestic (A) 6.0 6.0 Gardening (B) 2.0 0.0 Industrial (C) Process 60 49 Washing 4.0 4.0 Boiler 1.0 0.1 Cooling 2.0 0.2 Scrubber 1.0 1 Total ( Industrial)
68.0 54.3
Total (A+B+C) 76.0 60.3
Domestic water Consumption will be around 6 KLPD and sewage generated will be disposed to soak pit via septic tank @6 KLPD.
Gardening water consumption will be 2.0 KLPD Industrial effluent generation will be 54.3 KLPD which will send to Chhatral Enviro Management
System Pvt. Ltd for spray drying to achieve zero Discharge.
Product Batch Size(In
kg)
Production in
MT/Month
No. of Batches/Month
Water Consumption in KL/Batch
Effluent Generation in KL/Batch
Water Consumption
in KL/Day
Effluent generation in
KL/Day
Amisulpride 190 5 26 0.7 0.946 0.74 1.00
Azilsartan Medoxomil
50 1 20 3.2 2.505 2.56 2.00
Cinitapride Hydrogen Tartrate
35 1 29 0.7 0.73 0.80 0.83
Indoline 0.9 5 5556 0.0061 0.0028 1.36 0.62 Linagliptin 61 1 16 4.177 2.25 2.74 1.48 Losartan Potassium 83 5 60 2.21 2.4 5.33 5.78 Luliconazole 100 1 10 0.2 0.221 0.08 0.09 Moxifloxacin 78 1 13 0.5 0.6 0.26 0.31 Nebivolol 22.5 1 44 0 0 0.00 0.00 Olmesartan Medoxomil
152.6 1 7 7.094 6.0507 1.86 1.59
Rosuvastatin Calcium 100 5 50 2.05 1.621 4.10 3.24
Sertaconazole Nitrate
3.5 1 286 0.066 0.0704 0.75 0.80
Setraline HCl 25 1 40 0.25 0.316 0.40 0.51 Sitagliptin 40 5 125 0.58 0.6325 2.90 3.16 Sofosbuvir 135 1 7 9.724 7.2 2.88 2.13 Tapentadol HCl 50 1 20 0.1 0.15 0.08 0.12 Telmisartan 3.03 5 1650 0.00429 0.006 0.28 0.40 Teneligliptin Hydrobromide
1.23 5 4065 0.0271 0.03285 4.41 5.34
Ursodeoxycholic Acid
465 5 11 5.21 5.464 2.24 2.35
Velpatasvir 200 1 5 3.6 4.28 0.72 0.86 Vilazodone 200 1 5 3.42 4.1 0.68 0.82 Voriconazole 200 1 5 1.91 1.484 0.38 0.30 Pregabalin 700 25 36 2.8 1.981 4.00 2.83 R-CMH 504 25 50 4.8 2.532 9.52 0.00 (+)-3- (carbamoylmethyl)-5- methylhexanoic Acid
1260 50 40 3.5 4.543 5.56 7.21
Phenylphrine HCl 550 5 9 0 0 0.00 0.00 L-Phenylephrine Base
460 5 11 2.5 1.205 1.09 0.52
DL-Phenylephrine Base
238 5 21 1.25 3.254 1.05 2.73
Gliclazide 875 7 8 0 0 0.00 0.00 Sucralfate 1160 25 22 4 2.056 3.45 1.77 Levosulpiride 1250 10 8 0 0 0.00 0.00
Water Balance Diagram
Note: Industrial Effluent will be primary treated at In-house ETP and finally discharge to Chhatral Enviro Management System Pvt. Ltd for spray drying to achieve zero discharge.
Water Consumption 76
Domestic 6
Sewage
2
Gardening 2
Industrial 68
Process 60
Boiler 1.0
W/W 49
Cooling 2.0
W/W 4
Scrubber 1.0
Blow down 0.1
To Soak Pit/ Septic Tank
Washing 4.0
All unit in KL/Day
To ETP 54.3
Blow down 0.2
W/W 1
Enclosure: 10
Details of Effluent Treatment Plant
Sr. No. Name of Unit No. of Unit Size (Feet)
1. Collection Tank 2 12×12×7 (Each)
2. Neutralization Tank 2 12×12×7 (Each)
3. Primary Settling Tank 1 16×16×7
4. Final Collection Tank 1 60 KL
5. Sludge Drying Bed 4 ---
Enclosure: 11
Details of Flue Gas Emission And Process Gas emission system with APC System
Details of Flue Gas Emission:
Sr. No.
Stack Attached To
No. of Unit
Stack Height (m)
Air Pollution Control Measure
Pollutants SPM
mg/NM3 Sox
PPm NOx
PPm
1 IBR Boiler (3 MT/Hr) 1 16
Multi Cyclone Dust collector and Bag Filter
<150 <100 <50
2 Hot Air Generator 1 16
Multi Cyclone Dust collector and Bag Filter
<150 <100 <50
3 D.G. Set 1 9 --- <150 <100 <50
Details of Process Emission:
Sr. No.
Stack Attached To
No. of Unit
Stack Height (m)
Air Pollution Control Measure Pollutants
1. Reaction Vessel 1 16
Two Stage Scrubber System
Scrubber NH3
2. Reaction Vessel 1 16
Water Scrubber Followed By
Alkali Scrubber
SO2<100 ppm
3. Reaction Vessel 1 16 Water Scrubber HCl
4. Reaction Vessel 1 16 - N2
5. Reaction Vessel 1 16 --- HBr
Fuel Requirement:
Sr. No Name of Fuel Quantity
1 Briquette/Agro Waste/Bio Coal 9 Ton/Day
2 Diesel 10 Lit. /Hr
Enclosure: 12
Details of Hazardous Waste Generation with its Management
Sr. No.
Type of Hazardous Waste Cat. No.
Quantity Management
01 ETP Waste 26.2 250 MT/Annum.
We will pack all our generated ETP waste into HDPE bags. Then after we will store it into proposed Solid Waste Storage Area. Then after it will be disposed to TSDF as we will become the member of it after obtaining Environment Clearance.
02 Discarded Containers 33.3 500 Nos./M We will store all our discarded containers into provided solid waste storage area. Then after it will be return back to raw material supplier or use for packing of ETP waste.
03 Spent Oil 5.1 10 Lit/Yr. We will store into carboys and then after it will be reuse as a lubricant in our plant machineries.
Enclosure: 13
Name and Address of Director
Sr. No. Name Address
1. Jagdish Kantilal Sheth 23, Ashwavilla Bunglows off. S. G. Road sindhu Bhavan, Thaltej,
Ahmedabad-380059
2. Keyur Jagdishchandra sheth 23, Ashwavilla Bunglows off. S. G. Road sindhu Bhavan, Thaltej,
Ahmedabad-380059
Enclosure: 14
Land SuPPorting Document
Enclosure: 15
Site Plan and Layout Plan
(Attached)
904
905/P
904
905/P
903/1
903/2
906
907
913
908
909
910
911
912
VILLAGE BOUNDARY OF DHANOT
902
V
I
L
L
A
G
E
B
O
U
N
D
A
R
Y
O
F
A
N
K
H
O
L
905/P
R
A
I
L
W
A
Y
L
I
N
E
914
QA-QC-MICROBIOLOGYLAB (R&D AND PROCESSDEVELOPMENT LAB G+1)
200 SQ MT
RO
AD
RO
AD
9.1
44 R
OA
D
RO
AD
R
O
A
D
9.144 M
T R
OA
D
RO
AD
APi S
TORA
GE A
NDDI
PATC
H AR
EA (
G+1)
250
SQ M
T
RM STORAGE GODOWN1200 SQ MT.
STOR
AGE
AREA
-IN
TERM
EDIA
TES
100
SQ M
T.
INTERMEDIATEPRODUCTION AREA
(G+2)700 SQ MT.(PRESENT)
ADMIN BUILDING(G+1)
200 SQ MT.
ETP500 SQ MT.
FINI
SHED
GOO
DS -
INTE
RMED
IATE
S80
SQ M
T.
PHARMA PRODUCTION AREAINCLUDING DRYING &
PACKAGING AREA (G+1)500 SQ MT.(PRESENT)
TANK FARM550 SQ MT.
UTILITY AREA415 SQ MT.
CANTEENFOR
STAFF/WORKER(G+1)
150 SQ MT.
SECU
RITY
CAB
IN50
SQ M
T.4.5 MT WIDE ROAD
4.5 MT WIDE ROAD
4.5
MT
WID
E RO
AD
4.5 MT WIDE ROAD
EXIT
ENTRY GATE
GATE
PILO
T PL
ANT
175
SQ M
T.
WAITING /FIRST AID /
CRECHE / CHANGE RMFOR STAFF & WORKERS
200 SQ MT.
UG TANK, PUMP HOUSE& RO WATER PLANT
140 SQ MT.
TWO AND FOUR WHEELER PARKING455 SQ MT.
18.0
MT
WID
E RO
AD
BORE WELL
PHARMA PRODUCTION AREAINCLUDING DRYING &
PACKAGING AREA (G+1)335 SQ MT.(FUTURE)
INTERMEDIATEPRODUCTION AREA
(G+2)465 SQ MT.(FUTURE)
STP
TWOPOLE
STRUCTURE
MECH. UTILITIES HVAC
ELECTRICAL---
FIRE SAFETY
01. ARCHITECTURAL :02. STRUCTURAL :03. HVAC :04. ELECTRICAL :05. UTILITIES :
REF. DRGS. :
ASSOCIATES :
---
--- ---
-------------------------
DESCRIPTION CHECKEDDATEREV NO. DRAWN
GENERAL NOTES :
KEY PLAN
N
---- ---- ---- ---- ----
SCALE
CHECKED
DRAWN
DESIGNED
DRAWING NUMBER :
DATE :
REVISION
APPROVED
PROJECT NO:
S3M DESIGN CONSULTANTS LLP
ENGINEERING + PLANNINGPHONE: +91 (079) 66118122/66118123W: www.s3mconsultants.com E: [email protected]
B-801, WESTGATE, NEAR YMCA CLUB, S G HIGHWAY, AHMEDABAD-15.
THIS DRAWING IS EXCLUSIVE PROPERTY OF "S3M DESIGN CONSULTANTS LLP"AND SHOULD NOT BE USED,COPIED,REPRODUCED AND EXHIBITED IN ANY WAYDETRIMENTAL TO OUR INTEREST WITHOUT OUR WRITTEN CONSENT.
MASTER LAYOUT---
ALT-03 R0APPROVAL
A1:300
13-03-2018
KETAN
J.M
J.M
J.M
ATLAS LIFE SCIENCESAT CHHATRAL
----
A1
Enclosure: 16
Valuation Certificate
(Attached)