empower 3 enterprise - waters · pdf fileempower 3 enterprise architecture ... • citrix...

08-Sep-11

Chapter 1 1

©2011 Waters Corporation

Empower 3 Enterprise Architecture


Empower 3 Enterprise Architecture

Topics covered in this section:

� Available Empower 3 Enterprise configurations

• Empower Workgroup

• Empower Enterprise Traditional

• Empower Enterprise High Availability

• Citrix Server Farm

• Real Application Cluster (RAC)

• Data Guard

• VMware Virtualization

• Combination

� Empower Optional Applications

• Dissolution, Method Validation, Method Development

• Waters Data Converter 2, Enterprise Data Manager

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Chapter 1 2


Corporate Backbone Firewall

Office

Clients

GC Lab

LC/MS/MS Lab

LC LabHPLC / UPLC

Secure Server Room

SQD /TQD

5890/68907694

Xevo G2 Tof / Qtof

e-SATIN

A1100 AllianceA1200

ACQUITY

Private Ethernet

Private Ethernet

6850/7890

Xevo TQ-S

Typical Empower Network

Office


Empower Network Scalability

10 named user licenses


unlimited named user licenses

Personal

Workgroup

Enterprise



unlimited named user licenses

Personal

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Chapter 1 3


Parts of the Empower 3 Enterprise System

Acquisition Client

LAC/E32

Database Server

Processing Client


Client-Server Environment

ChromatographicSystems

DatabaseServer

AcquisitionServer

Raw DataServer

EmpowerClient

EmpowerClient

EmpowerClient

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Chapter 1 4


Citrix Environment

ChromatographicSystems

DatabaseServer

AcquisitionServer

Raw DataServer

CitrixServer

CitrixServer

CitrixServer

Citrix Client


Citrix Benefits

� Simpler administration.

— Since applications are loaded on the terminal server, administration and validation are limited to the Citrix servero Faster and simpler software deployment can be accommodated very quicklyo Reduce the time required for validation, software qualification is reduced to

the Citrix server itself - the clients do not require qualification.

� Optimize the network bandwidth used by this technology— Independent Computing Architecture (ICA)

o Ability to separate application logic from the user interface. The client user works with the application interface while 100% of the application executes on the server.

o Only screens, mouse clicks and keystrokes travel the network

o Reduces bandwidth consumption and transmitted packets for greater network efficiency

— The Empower application network traffic is limited between the Empower Database and Citrix server

� Load balancing— The Empower processing is distributed over multiple servers

in a Citrix Farm that ensures the continuity of performances

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Chapter 1 5


Real Application Clusters (RAC) Overview

� Multiple servers at the same site serving the same database

for high availability, performance, and redundancy in case

of server failure.

Server 1

CPU CPU

Server 2

CPU CPU

Server 3

CPU CPU

Server N

CPU CPU…


Real Application Clusters (RAC) Overview

� A clustered database – a group of independent computers

working together as a single system

— Redundancy /fault tolerance - Protect from server failure

— High availability – continues running in event of a hardware or

software failure

— Performance – workload is distributed amongst nodes for

optimal performance (load balancing)

— Scalability – as the environment grows, simply add more

servers with no downtime

� Provides the flexibility of running many databases in one

cluster with the ability to share the infrastructure amongst

the different databases

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Chapter 1 6


RAC - Benefits

� Redundancy

� High availability – fault tolerance

� Performance

� Non-disruptive scalability

— Expand capacity by simply adding servers to your cluster with no

downtime

� Flexibility

— manage single or multiple databases (applications) in a single cluster of

server nodes

— Efficient to manage using built-in tools

� Reduce capital and operating costs without compromising the

highest quality of service

— Uses low cost standard hardware, Low cost clustered servers, Low cost

consolidated storage (as compared to mainframe SMP computers)

— High availability + scalability = reduced total cost of ownership


Data Guard Mirrored Sites

SYNC/ASYNC

Data Guard Broker

Primary Site

PrimaryDatabase

Active Standby Site

Physical or Logical Standby Database

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Chapter 1 7


� Mirrored servers for redundancy in case of site failure

— Remote site (vs. local site) recommended; either possible

� Guard against data failure and disaster and eliminate idle

redundancy

� A remote, hot, synchronized standby database ready to take

over processing activities if the primary site fails

� Provides disaster protection against planned or unplanned

outages at the production site

Data Guard


Data Guard

� Reduction of planned downtime

— Standby database used to perform planned

maintenance in a rolling fashion

o hardware or OS maintenance, site maintenance,

upgrades to new database patch sets or

releases, database changes

o Maintenance is first performed on a standby

database. Production is switched over to the

standby database and then switched back when

the maintenance tasks are completed.

o The only downtime is the time needed to effect

a switchover operation.

— A physical standby database, because it is an

exact replica of the primary database, can

also be used to offload the primary database

of the overhead of performing backups.

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Chapter 1 8


Data Guard - Benefits

� Disaster recovery at a reduced cost

— Data protection in the event of site failure

— A Data Guard physical standby database can serve as a

maintenance and test database—no additional storage or

servers required

— Traditional HA requires expensive, idle, standby hardware from

multiple hardware and solution vendors

� Centralized, simplified management

— Management, monitoring, and automation software is built in

to eliminate management complexity that accompanies

traditional replication solutions

� Improved Technology

— The reporting replica is up to date and online at all times,

which is not possible with traditional storage mirroring

technology


RAC + Data Guard

� RAC and Data Guard are complementary technologies providing the

highest possible level of scalability, availability, and data protection

� RAC and data guard typically run together; RAC for instance failure

protection, Data Guard for site failure protection

� Both primary and remote sites typically use RAC

� Managed as a single configuration

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Chapter 1 9


Virtualization

� Rapid deployment

� Disaster recovery

� Validation benefit

� High availability

� Server consolidation

� Scalability


What is Virtualization?

� An encapsulated environment running its own operating system and application(s) as if it were a physical computer but sharing the hardware resources of the computer (including CPU, RAM, hard disk and network controller) with other virtualized environments on the same computer

� Virtualization lets you run multiple virtual machines on a single physical machine (consolidation)

— Virtual machines on the same computer are isolated from each other as if physically separated

— A virtual machine behaves exactly like a physical computer

— An operating system can’t tell the difference between a virtual machine and a physical machine, nor can applications or other computers on a network.

� End users do not know they are connecting to a virtual machine

� Precursor to cloud computing

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Chapter 1 10


VMware Architecture

From VMware Virtualization Overview White Paper


VMware Benefits

� What Empower components to virtualize?— The High Priority - Empower database server , Empower Citrix server, and the

Empower file server.

— Virtualizing Clients and the LAC/Es have a much lower interest.

� Validation benefits— Changes to other VMs on same computer do not affect the validation of the

Empower VM

� Rapid deployment and disaster recovery— Virtual images are similar to computer images but are hardware independent

and can be deployed on dis-similar computer

— Require less time to deploy than a conventional installation

— Allow to run Empower 1154 or Empower 2154 with Empower 3 on the same computer all have different OS version and Oracle version

— Allow you to capture snapshots and return to the snapshot image in the time that it takes to reboot

� HA, server consolidation, scalability and reduction in capital costs— A virtual machine lets you share the resources of a single physical computer

across multiple virtual machines for maximum efficiency.

— requires less hardware – reduces your physical infrastructure footprint by consolidating excess server and desktop hardware

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Chapter 1 11


Optional Applications


Optional Applications

� System Suitability

� Chemical Structures

� Method Validation

� GPC / SEC

� Dissolution

� ToolKit

� Enterprise Data Manager

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Chapter 1 12


Automated Dissolution


Method Validation Manager

Reports Compiled

PrepareStandards & Samples

Data Acquisition& Processing

Data Management

Corporate Method ValidationSOP

Calculation Statistical Results

MethodValidationManager

Create SampleSequence

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Chapter 1 13


Method Validation Manager Tools

� Run Samples

� Edit Sample Set

� Alter Sample

� Review

� Process

� Validation Process

� Validation Review

� Preview

� Approve Data

� Update


Manage Method Validation Workflows

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Chapter 1 14


Chemical Structures

� Integrate chemical structures to improve data management

and reporting

� Perform structure searches, assign structures to components

and connect to corporate structure databases


Method Development Approach

Method Screening

Method Development

Method Validation

Re-development& Re-work

Automated Method

Development

� Overlay graphs visualize regions of optimum method

performance and robustness

� Robust and reliable LC methods predicted automatically

� Modification of parameters within defined design space

are not considered change

� QbD approach that meets regulatory guidelines

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Chapter 1 15


Optimum Method Performance and Robustness

Design Space of Robust Method


Fusion with Acquity UPLC

AU

-0.005

0.000

0.005

0.010

0.015

0.020

0.025

0.030

0.035

0.040

Minutes

1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 5.50 6.00 6.50 7.00

1.5

91

2.2

29

2.8

33

3.2

86

3.7

33

4.1

25

4.3

10

4.4

82

4.5

94

Imp A

- 4

.738

Imp B

- 4

.947

API 1 - 5

.189

API 2 - 5

.661

Lastp

eak - 6

.128

ACQUITY UPLC3 columnsGradient conditionsGradient slopesMobile phase compositionspHPump flow rate

AU

0.000

0.010

0.020

0.030

0.040

0.050

0.060

0.070

Minutes

1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 14.00 15.00 16.00 17.00 18.00 19.00 20.00

HPLC10 columnsIsocratic & gradient conditionsGradient slopesMobile phase compositions

45 days

2 days

08-Sep-11

Chapter 1 16


Waters Data Converter 2

� Empower option Waters Data Converter 2 (WDC 2)

� Manual and automated import of raw data into Empower

� Available import filters:

— MassLynx (included)

— ChemStation 32 bit (option)

— Turbo-/Totalchrom (option)


WDC2 Overview

Browse for data or folders with data

Drag & drop data

Import to Empower

If needed, change project, edit parameters

Import log

Status

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Chapter 1 17


WDC2 Auto Mode

Scan configurations

for import

Data are scheduled for import

Import according to parameters

Start/Stop scanning for data

Reporting as configured


Enterprise Data Manager

� Manage data footprint through advanced archival logic

— Central administration of project archive process for one or more

Empower servers

— Automated scheduling of project archive process based on

predefine rules

— Automated archive verification prior to project deletion

— Long term archival on external media

� Improving speed and accuracy of report retrieval

� Extended availability of electronic reports

— Review records without Empower

� Review and approve electronic reports through web browser

— Low deployment and training costs

08-Sep-11

Chapter 1 18



Sample

Instruments

Data file and project capture

MetadataEnhanced metafile

Empower EDM

Printed reports

Empower Projects

Empower Reports



Find, review and approve through a web browser

08-Sep-11

Chapter 1 19


Centralizing All Instrument Qualification Records in EDM

Benefits

� All system qualification reports centrally managed in a single

electronic repository

� Web-based solution for electronic review, approval, and

regulatory inspections

� Report traceability back to archived projects for easy retrieval

� Reduced document warehousing costs

� Eliminated waste and

non-value added steps

in the process


LIMS Interface

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