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Empower 3 : Designed for the EnterpriseEmpower 3 : Designed for the Enterprise

Lauren WoodLauren Wood

September 2010September 2010

©2010 Waters Corporation | COMPANY CONFIDENTIAL

AgendaAgendagg

Trends in the industryTrends in the industry

Overview of technologies— Citrix

O l RAC (S Cl t )— Oracle RAC (Server Clusters)

— Oracle Data Guard (Site Mirroring)

— VMWare Virtualization

— Toolkit Improvements

©2010 Waters Corporation | COMPANY CONFIDENTIAL 2

Industry TrendsIndustry Trendsyy

Harmonization & StandardizationHarmonization & Standardization

Centralization

Reduce the Total Number of Software Applications

Software Integrations and Interoperability

Improve Laboratory EfficienciesImprove Laboratory Efficiencies

Lower Total Cost of Ownership


Designed for the EnterpriseDesigned for the Enterpriseg pg p

Optimized for Enterprise DeploymentOptimized for Enterprise Deployment— Highly available

— Highly redundant

Optimal performance— Optimal performance

— Lowered computing and administrative costs

— Rapid Deployment

— Scalability

— Disaster recovery

— Interoperability with

other applications


ClientClient--Server EnvironmentServer Environment

Database Raw DataEmpower Empower Empower DatabaseServer

Raw DataServer

EmpowerClient

EmpowerClient

EmpowerClient

AcquisitionServerServer


ChromatographicSystems

Citrix EnvironmentCitrix Environment

Database Raw Data

CitrixServer

CitrixServer

CitrixServer

Citrix Client Database

ServerRaw Data

Server

AcquisitionServerServer


ChromatographicSystems

Oracle Real Application Clusters (RAC)Oracle Real Application Clusters (RAC)pp ( )pp ( )

S 1 S 2 S 3 S NServer 1

CPUCPU CPUCPU

Server 2

CPUCPU CPUCPU

Server 3

CPUCPU CPUCPU

Server N

CPUCPU CPUCPU…


Mirrored SitesMirrored Sites

Primary SitePrimary Site Active Standby SiteActive Standby Site

SYNC/ASYNC

Primary SitePrimary Site Active Standby SiteActive Standby Site

Broker

Primary Physical or Logical PrimaryDatabase

Physical or Logical Standby Database


Clusters and MirroringClusters and Mirroringgg

Clustering and site mirroring are complementary technologies providing the highest possible level of scalability, availability, and data protection

Both primary and remote sites typically use clustering

Managed as a single configurationg g g

SYNC/ASYNCPrimary SitePrimary Site Active Standby SiteActive Standby Site

Broker

PrimaryDatabase

Physical or Logical Standby Database


VMWareVMWare VirtualizationVirtualization

An encapsulated environment

Allows multiple virtual machines on the same computer Allows multiple virtual machines on the same computer

Isolated from each other as if physically separated

Software applications and OS cannot distinguish between a VM and a physical machinephysical machine


Benefits of Benefits of VirtualizingVirtualizing Empower 3Empower 3gg pp

Rapid deployment

Disaster recovery

High Availability

Server consolidationDisaster recovery

Validation benefits

Server consolidation

Scalability


Improvements to Software Toolkit Interface

Support for Web Services

Allows creation of web based applications interoperating with Empower

Increased manageability for developer

Improved performance and usability


E3: Designed for the EnterpriseE3: Designed for the Enterpriseg pg p

Highly available, Highly Redundant, Optimal P f

Scalability Server clusters

Cit i fPerformance— Server clusters

— Site mirroring

Cit i f

Citrix server farm

VMWare virtualization

Server consolidation— Citrix server farm

— VMWare virtualization

Lowered computing and d / l d

Server clusters

VMWare virtualization

Disaster Recoveryadministrative/validation costs— VMWare virtualization

— Site mirroring

— Virtualization

Interoperability— Citrix

— Server clusters

— Site mirroring

p y— Empower 3 architectural changes

to support a wide area network


Rapid deployment VMWare virtualization

Citrix

Benefits Empower SoftwareBenefits Empower Softwarepp

Business Benefits— Leverage existing capital investmentsLeverage existing capital investments

— Reduced training and maintenance effort

— Lower total cost of ownership

Laboratory Benefits Laboratory Benefits— Improved laboratory productivity and effectiveness

— Consistency of data storage, audit trails, tools and techniques

— Intuitive chromatographic data handling and processing

— Improvements in global communication

— Streamlined Method Development and Validationp

Compliance— 21 CFR Part 11 compliant ready

Minimized inspection time


— Minimized inspection time

Empower 3 Feature Release 1Empower 3 Feature Release 1pp

Empower 3 Feature Release 1Empower 3 Feature Release 1— Virtualization on VM Ware (DB and Citrix Farm)

— Oracle RAC

Oracle Dataguard— Oracle Dataguard

— SDK Web Services

— Sun Solaris

— Auditing non-Empower access to database

— 7890 Dual Tower support


Empower 3 Feature Release 2Empower 3 Feature Release 2pp

Dissolution, 20 Bath Support and USP Multi-Stage Protocol— Usabilityy

Method Validation Manager— Relative acceptance criteria

Imp o ements to Stabilit Filte Validation and Specificit — Improvements to Stability, Filter Validation, and Specificity Tests to allow validation of impurity methods

— Content uniformity

System Policies based on Project Hierarchy

Workflow enhancements

Ease of use enhancementsEase of use enhancements

Waters welcomes your suggestions and inputWaters welcomes your suggestions and input


Waters welcomes your suggestions and inputWaters welcomes your suggestions and input

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