emotional memory ( the prefrontal cortex) & phineas gage b9902052 陳 黎 b9902068 曾資斌
TRANSCRIPT
Emotional Memory ( The Prefrontal Cortex)
& Phineas Gage
B9902052 陳 黎B9902068 曾資斌
A Gruesome but True Story
Phineas P. Gage (1823 –1860) construction foreman left frontal lobe destroyed effects ?
"no longer Gage".
左前額葉皮質嚴重損壞
生理機能正常
情緒表現異常
左前額葉與生理機能無關
左前額葉與情緒表現相關
How?
The Limbic System
Before & After
Take a Closer Look……BeforeAfterWhy?? Prefrontal cortex damaged
Emotionallydetached
impatient
erratic
The Lymbic System
Prefrontal cortex(PFC)
Frontal lobe
granularelectrical stimulation
evoke movements
Motor cortexPremotor areaPrefrontal cortex
FunctionImportance?
CEO of the brain
Jiminy cricket“It is the tiny voice help you decide
what is right and wrong.”
When PFC goes wrong…
運作過度……
活動低落…… (lack of dopamine)
What happened to Gage?• Destroyed• Not destroyed
PFC & ADHD意力不足過動障礙症 (過動症 )Attention Deficit Hyperactivity
DisorderWhy? Dopaminedopa decarboxylase 多巴脫羧酵素
Lobotomy 前額葉切離手術
Egas Moniz, 1935
Schizophrenia, clinical depression
Connections to PFC
Reference PHINEAS GAGE : A Gruesome but True Story About Brain Science,
by John Fleischman, 2002 Making A Good Brain Great, by Daniel G. Amen, 2007 認識你的頭腦 , 洪祖培教授、邱浩彰醫師著 http://en.wikipedia.org/wiki/Prefrontal_cortex http://en.wikipedia.org/wiki/Lobotomy http://www.dls.ym.edu.tw/neuroscience/adhd_c.html http://sanitaryplaza.blogspot.com/2007/07/lobotomy.html