Emery Pharma ServicesAnalytical, Microbiology and Synthetic Services Worldwide

About us

• Experienced CRO supporting small business and large government contracts:

• Over 60 years of combined experience in drug

discovery support and innovation

• Pharmaceutical method development and consulting

• “Hard to solve problems” are our specialty

• Analytical chemistry (NMR, LCMS, HPLC)

• Microbiology (MIC, MBC, MFC, Time Kill)

• Formulations (nanotechnology)

• Custom synthesis

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NMR Spectroscopy

• Bruker 400 MHz spectrometer

• Analyzes Small (<1kD) molecules, synthetic or natural

• 1-D: 1H, 13C, 19F, 31P, 15N, 11B, and more

• 2-D: 1H-1H, 1H-13C, and more

• Variable temperature

• T1 measurement

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LC-MS

• Separates molecules using column (C18 or other)

• Small (0.1-2 kD) molecules, synthetic or natural,

purified or mixture

• Unique set up: allows for detection of virtually any

molecule

• PDA: detects 200-800 nm

• ELSD: detects non-volatile material and non UV active

• MS: dual ESI/APCI ionization, detects charges

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Organic synthesis

• FTE or project based

• Small molecule and building block synthesis from milligram to kilogram scale

• Comprehensive analytical characterization

• Large scale LC purification capability (both Normal- and Reversed-Phase)

• Fast and efficient optimization of chemical reactions based on proprietary methods

• Hit-to-Lead / Lead optimization (SAR studies, compounds for PK studies, etc.)

• All compounds are guaranteed a minimum of 95% purity

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Formulations services

• All types of Pre-formulations and product developments of small molecules with liposomes (parenteral) and other type of drug delivery systems (dermal, ocular and others)

• Process development, scale-up technology transfer and process optimization and filtration studies.

• Writing protocols, performing stability and container-closure compatibility studies

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STEALTH Liposome

Formulation Analytical Services

• HPLC method development

• HPLC measurement of drug potency and degradation

• Formulation stability (chemicals and physical testing)

• pH and osmolality

• Review stability reports and shelf-life assessments of drug

products

• In-vitro drug release testing, topical and ocular tissue

permeation by Franz cell

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Multi Station Franz Diffusion Cell System

MIC / MBC / MFC / Time Kill

• Measures inhibition of growth or killing of bacteria and fungi as a function of concentration and/or time

• Test articles can be natural or synthetic, mixtures or purified

• Hundreds of bacterial strains available including drug-resistant clinical isolates

• Multiple fungal strains available

• Antiviral testing also available

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Resistance Testing

• Tests potential for development of resistance to antibiotics

• Multiple passage at sub-lethal concentrations of antibiotics

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• Biofilm models test "real-world"

conditions

• Calgary Biofilm Device (MBECTM)

• Drip-flow reactor

• CDC reactor

• MRD reactor

• In vitro urinary catheter

crystalline biofilm model

• Colony biofilm

• Custom reactor design

Biofilm Testing

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Cytotoxicity in Cell Cultures & Tissues

• Sensitivity of human cells and

human tissues to test articles

• IC50 measurement

• Multiple cell lines available

• EpiOcular multilayered tissue

mimics corneal epidermis

• EpiDermal multilayered tissue

mimics stratum corneum

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Microscopy

•Visualization of bacteria,

cells and tissues

•Confocal microscopy

•Fluorescent microscopy

•Stereozoom microscopy

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Acanthamoeba castellanii trophozoites Acanthamoeba castellanii cysts

Emery Pharma Services: Analytical, Microbiology and

Synthetic Services Worldwide

For more information please visit our website:

http://www.emerypharmaservices.com/

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