Quality. Value. Delivered.

Corporate Presentation 2016

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Our Mission:

“Combine the strength of our expertise, experience, and innovation to provide the best chemistry and biology R&D services available.”

“Your projects are our projects, your successes are our successes!”

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About us

• We combine the best intellectual resources with the most sophisticated equipment and instrumentations.

• We offer: • Medicinal Chemistry • Bioanalytical Chemistry (Including HPLC method development) • Analytical Chemistry (NMR, LCMS) • Microbiology (MIC/MBC, Synergy, Biofilm testing)

• Over 60 years of combined experience in drug discovery support and innovation

• Pharmaceutical method development and consulting• “Hard to solve problems” are our specialty

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We add value to your projects

• We operate as an extension of your R&D department. • Duration of collaboration is flexible: can last from weeks to months • Here is what one of our clients said about us (for additional reviews

please visit our website) :

“Emery Pharma provides endless support in supplementing and streamlining our research &

development efforts. With their impressive laboratory and knowledgeable team, the company is able

to tackle any problem we propose, at low costs and in a short lead-time. Emery Pharma has greatly

exceeded our expectations and is an integral part in advancing our product development.”

-Connora Technologies

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Medicinal Chemistry

We provide the following services:

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• Designing & synthesizing new analogs

• Computational chemistry support

• Developing Intellectual Property

• Competitive analysis

• Patent expansion on current commercially available or clinical stage molecules

• Product development support from bench to clinic

• “Patent evergreening” / analysis

• Troubleshooting specific optimization issues including impurity profile analysis

• Expert witness services • Creating compound candidate profiles

Bioanalytical Chemistry

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• We offer proprietary assays and method development to analyze wide range of samples including but not limited to:

• We also provide a collection of standard methods,

method validation, and method transfer

• Blood Plasma • Urine • Formulated Products

• Serum • Feces • Environmental Samples

• Tissue • Raw Materials

Analytical Chemistry

• Bruker 400 MHz spectrometer

• Analyzes Small (<1kD) molecules, synthetic or natural

• 1-D: 1H, 13C, 19F, 31P, 15N, 11B, etc.

• 2-D: COSY and NOESY (1H-1H) , HSQC (typically1H-13C), HMBC, DOSY and more

• Variable temperature

• T1 measurement

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NMR Spectroscopy

Analytical Chemistry

• LC-MS services are designed for both standard and custom methods of characterizing molecules, formulations, or solutions.

• Our LC-MS system has three orthogonal detection methods: allows for detection of much wider breadth of molecules than most LC-MS systems.

• PDA: detects 200-800 nm

• ELSD: detects non-volatile material and non UV active

• MS: dual ESI/APCI ionization, detects charges

• Suitable for analysis of: small molecules, antibody fragments, formulations, and solutions.

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LC-MS

Antimicrobial susceptibility testing - MIC/MBC Assays

• Minimum Inhibitory Concentration (MIC)• Measures antimicrobial susceptibility and sensitivity by inhibition of growth

of bacteria or fungi as a function of concentration

• At EP we use either disc diffusion, agar dilution or broth microdilution MIC methods, depending on the test article

• Minimum Bactericidal Concentration (MBC) / Minimum Fungicidal Concentration (MFC) • The lowest concentration of an antibacterial drug that results in a 99.9%

reduction in the initial microbial density

• When performed in conjunction with MIC, can determine if antimicrobial compounds are bactericidal or bacteriostatic

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Antimicrobial Synergy – Checkerboard Testing• Determines the effect on potency of the combination of antibiotics in

comparison to their individual activities, represented as the Fractional Inhibitory Concentration (FIC) index value

• We at EP perform synergy testing to calculate the FIC index value on our wide collection of bacterial strains ready for immediate use

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Biofilm Testing

• Biofilms produced by bacteria render most of currently available antibiotics ineffective by creating a “shield” through which antibiotics cannot penetrate through

• Developing antibiotics that can penetrate through biofilm is vital, especially in the healthcare setting

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• To test a compound’s ability to penetrate bacterial biofilm, at EP we use the Minimum Biofilm Eradication Concentration (MBEC) assay in which we have years of experience performing

Time-Kill Kinetic Assay

• Determines the time required by the antimicrobial agent to kill the test microorganism

• Determines the number of bacteria killed at each time point

• Synergy time-kill is also available at EP

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Cytotoxicity Testing

• Emery Pharma offers the following methods for cytotoxicity evaluation:

• We offer a vast inventory of human and other mammalian cell lines:

• Your results will be determined in the form of a CT50 value, the dose or concentration at which a test compound kills 50% of cells in vitro

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• Agarose Overlay • Indirect Contact Agar Diffusion Test

• MEM Elution • MTT Assay

• Direct Contact Cytotoxicity

• Human fibroblast cell line (ATCC® CCL-1) • Peripheral blood monocyte cell line (ATCC® TIB-202)

• Lung epithelial cell line (ATCC® CRL 2503) • Kidney epithelial cell line (ATCC® CCL-81)

U.S. Pharmacopeial Convention (USP) Methods

• At Emery Pharma, we are equipped to test products to ensure compliance with USP standards, in particular the USP testing methods details below.• Antimicrobial Effectiveness Testing (AET), USP <51>

• Microbial Examination of Nonsterile Products: Microbial Enumeration Tests, USP <61>

• Microbial Examination of Nonsterile Products: Tests for Specified Microorganisms, USP <62>

• We are able to provide a full range of services for companies and organization currently in their pre-clinical and clinical stages of R&D

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Since it’s founding in 2011, Emery Pharma has successfully partnered with over 100 companies.

Please contact us with any questions or for a FREE 1 hour consultation at (888) 983-6379 or internationally at +1 (415) 747-2087

email: info@emerypharma.com

References Available upon Request