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Global Alert and Response

Emerging and Dangerous Pathogens Emerging and Dangerous Pathogens Laboratory Network (EDPLN) Laboratory Network (EDPLN)

Emerging and Dangerous Pathogens Emerging and Dangerous Pathogens Laboratory Network (EDPLN) Laboratory Network (EDPLN)

Dr Renu Drager-Dayal, WHO GenevaDr Renu Drager-Dayal, WHO Geneva

Global Alert and Response

EDPLN successful outcome of two informal consultations, the first in Libreville, Gabon, in March 2008, and the second at WHO Headquarters in Geneva in February 2009.

BSL-4/BSL-3 human and veterinary laboratories able and willing to collaborate and cooperate, and share their knowledge, biological materials and experimental research results in real time to detect, diagnose and control novel disease threats.

25 Laboratories, 18 countries, 6 WHO regions

EDPLN Network DevelopmentEDPLN Network Development

Global Alert and Response

Network of BSL-4/BSL-3 human and veterinary laboratories intended: to support the diagnostic functions for laboratory response to

global epidemic threats of new, emerging and dangerous pathogens (Ebola, Marburg and other VHFs, SARS, Nipah, etc.)

to build capacity and transfer technology for safe and appropriate diagnostics to regional networks and countries in the zones of emergence to enhance earlier outbreak detection and faster and better management;

to provide surge capacity in response to epidemic activity that is geographically distributed or has the potential to become a global threat.

EDPLN Network GoalEDPLN Network Goal

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Ebola OutbreaksEbola Outbreaks

Nature Medicine 11, 720 - 721 (2005)

Global Alert and Response

Social Mobilization

AnalysisSamplesResultsEpi + Soc

Mobile teams

Triage IN / OUT

Barriernursing

EcologyHuman-animal

Database analysis

Follow-upof cases

Active searchfor cases

MedicalAnthropology

Posters

Radio - TV

TransportsVehicles

Epidemiological Investigation Surveillance Laboratory

Logistics Security

Communications

Community

Discussion

police

Environment

Vector Control

Health Education

Traditionalhealers

PsychoSocial

support

Case ManagementDeath Audits,

FuneralsInfection Control

Intersectoral CoordinationPolitical leadership

Clinicaltrials

Water andSanitation

Outpatient

Roads

Lodgingalimentation

COMBI *

(* COMBI = communication for behavior change)

EDP Outbreak Control Strategy and FunctionsEDP Outbreak Control Strategy and Functions

Financessalaries

MediaInformation

Risk Communication

Global Alert and Response

Ebola outbreak response : Laboratory

PCR EbolaHeinz FeldmannLCDC LaboratoryCongo Mbomo 2003

Global Alert and Response

Ebola HF outbreak response, Mweka, DRC.

Global Alert and Response

Technical Networks coordinated with GOARNTechnical Networks coordinated with GOARN

GOARNGOARN

EDPLN(BSL4 laboratories)

COMBI(Health education)

Clinical

Clinical Network EDP Laboratory Network Mathematical Modelling

Network Infection Control Network Behaviour Change/Social

Mobilisation Network

Global Alert and Response

EDPLN Structure

Secretariat

EDPLN Working Groups:

• Laboratory Outbreak Response

• Assay and Reagent Development

• Technology Transfer and Training

• International Engagement

- Biosafety / biosecurity

- Shipment of dangerous goods

• Applied Research

Applied Research

International

Engagement

Technology Transfer

and Training

Assay and Reagent

Development

Laboratory Outbreak Response

EDPLN

Global Alert and Response

Laboratory participation in WHO AFRO EDPLN-AFRICA Laboratory participation in WHO AFRO EDPLN-AFRICA Workshop Cape Town 11 -12 December 2010Workshop Cape Town 11 -12 December 2010

CIRMF-Gabon

NICD-South Africa

KEMRI-CDC

UVRI-Uganda

IP-Madagascar

IP-Senegal

IP-Côte-d'Ivoire

INRB-DRC

I-CAR

IP-Cameroon

Kenema-Sierra Leone

Reference BSL4 BSL3 labs with VHF diagnostic capacity

BSL3 and BSL2 labs with some VHF diagnostic capacity

International LabsNML/CanadaRKI/Germany NIH/USA

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VSV (50% ZEBOV in Rhesus at 30 min).

siRNA (100% ZEBOV in Rhesus at 30 min).

Monoclonal against coagulation (67% ZEBOV in Rhesus at 24 hours).

Different post-exposure Different post-exposure treatment optionstreatment options

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Expression of ZGP by Western Expression of ZGP by Western blotblot

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AcknowledgmentsAcknowledgmentsPHAC

Ami PatelKaylie TranMike GrayGregory SchumerJason RichardsonGary WongAllan ChandAlexander BelloAnders LeungDarryl Falzarano_______________________________

Jim StrongDarwyn Kobasa

University of Texas at Austin

Maria CroyleJoe Dekker

National Research Council

Amine Kamen

Rocky Mountain Laboratories

Heinz FeldmannHideki Hebihara

Wildlife Conservation Society

Ken Cameroun

CFIA

Hana WeingartlJames NeufeldGreg SmithKevin Tierney