embryonic development
TRANSCRIPT
Embryonic Development (mosly mice and mammals)
Chapter 10
Cleavage
Cell division without growth
First few divisionsare slow (24 hrs, then12 hrs)
Blastomeres
Products of cleavage
Compaction
Developing embryobecomes more spherical.
Flattening of blastomeresto form to maximize
intracellular contacts.
Microvilli
Cell membrane protrusions
and Gap Junctions
Cellular connectionsjoining cell cytoplasms
form
Porter, Fonte and Weiss, Cancer Research, 1974
Microvilli
Figure 20-22 Essential Cell Biology (© Garland Science 2010)
Gap Junctions
connexon proteins
Morula
Embryo from compactionto about the 32-cell stage
Desmosomesand tight junctionsform
Desmosomes
Localized, spot-like,cell-to-cell adhesions
Figure 20-22 Essential Cell Biology (© Garland Science 2010)
Figure 17-2a Essential Cell Biology (© Garland Science 2010)
Figure 17-2b Essential Cell Biology (© Garland Science 2010)
Tight Junctions
Junctions sealing neighboring cells together
so that water-soluble moleculescannot easily leak between them
Figure 20-22 Essential Cell Biology (© Garland Science 2010)
Figure 20-23a, b Essential Cell Biology (© Garland Science 2010)
Figure 20-23c Essential Cell Biology (© Garland Science 2010)
Blastocoel
Fluid-filled cavity
begins to form, forming...
the Blastocyst
Mammalian embryo after cavitation
the Blastocyst,
Mammalian embryo after cavitation
consisting of the Trophoectoderm, Blastocoel and Inner Cell Mass
Trophoectoderm
The outer layer of the blastocyst,which will form part of
the placenta
Inner Cell Mass
Will form the “embryo proper”and the amnion
Amnion
Extraembryonic membraneenclosing the embryo
Principles of Development 4e Wolpert/Tickle Copyright © 2011 by Oxford University Press
Fig. 3.20
ICM and trophoectoblastcells become determined
Late Blastocyst
Formation ofdistinct regions
Implantation
Emergence from the zona
Attachment to the uterine wall
Initial formation of the placenta
“Hatching”
Emergence from the zona; trophoectoderm cells
opposite the ICM secrete a protease
that digest the zona
Principles of Development 4e Wolpert/Tickle Copyright © 2011 by Oxford University Press
Fig. 3.23