eligibility of applicant

International Competitive GrantsAward Programfor Young Investigators

2007 APPLICATION

Letter from the Chairman and Introduction

Dear Young Investigator:

It is with great pleasure that I invite you to submit your application for The International Competitive Grants Award Program for Young Investigators. This 2-year international grant program is made possible by an educational grant provided by the GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease. The program enables Young Investigators to obtain funding for innovative research in cardiovascular disease.

The Foundation was established to promote the development of a new generation of cardiovascular clinician-scientists by supporting education on critical topics in cardiovascular diseases, supporting innovative research programs, and creating opportunities for international exchange of ideas. The grants award program is designed to foster the development of independent research and to encourage leadership in new

scientists. The Foundation Committee is comprised of dedicated international leaders who share the vision of developing quality research scientists in cardiovascular disease. It is with this in mind that we ask you to send your research proposal to the Committee for consideration.

Please take the time to review the instructions and complete the application. On behalf of the International Review Committee, we look forward to reviewing your application.

Sincerely,

Valentin Fuster, MD, PhDChairman

INTRODUCTION

The International Competitive Grants Award Program for Young Investigators is a 2-year international program enabling young investigators who have completed medical school within the past 10 years to obtain funding for innovative research in cardiovascular disease.

Young Investigators are defined as individuals who have graduated medical school within the past 10 years and are either currently enrolled in the later years of a cardiology fellowship program (beyond 2 years), are junior faculty members, or physicians who have completed a cardiology training program within the past 3 years.

Eligible candidates are required to submit a 2-year research plan on basic science or clinical research in cardiovascular disease according to criteria outlined herein. Research proposals must be reviewed and signed by the applicant’s research advisor and must be accompanied by a 1-page letter of recommendation, which outlines the career path and commitment of the Young Investigator.

A total of 6 grants are awarded annually. Each grant is $55,000 per year for 2 years. The grant should be used for salary support, unless salary is already covered, in which case the grant may be applied to other research costs. A stipulation for this grant is that the recipient’s institution may not sequester more than 10% for indirect costs. Because research proposals must be sustainable for a minimum of 2 years, it is imperative that applicants maintain the ability to fulfill their research commitment in accordance with the requirements and expectations set forth by the Foundation. To continue to receive the grant annually, progress reports will be required at 10 months and 22 months from the date of the grant issuance. If progress is not deemed sufficient, the grant may be discontinued. A complete report will be required at the conclusion of the grant period in September 2009. Grant recipients who publish their research during or following the completion of

Letter from the Chairman and Introduction

the grant are required to make proper acknowledgments to the GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease.

GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease:

International Review Committee

THE STRENGTH OF LEADERSHIPAn International Review Committee comprised of world-renowned cardiologists and leading physician-scientists will review each application and collectively determine the 6 grant recipients. The chairman for the GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease and the International Review Committee is:

Valentin Fuster, MD, PhD, ChairmanRichard Gorlin, MD/Heart Research Foundation Professor of CardiologyDirector, The Zena and Michael A. Wiener Cardiovascular Institute and The Marie-Josée and Henry R. Kravis Center for Cardiovascular HealthMt Sinai School of MedicineNew York, NY

Committee Members

A. John Camm, MD, FRCPProfessor of Clinical CardiologyThe Prudential Chair of CardiologySt George’s Hospital Medical SchoolUniversity of LondonHonorary Consultant in CardiologySt George’s HospitalLondon, England

Henry J. Dargie, MB, FRCPConsultant CardiologistCardiology DepartmentWestern InfirmaryUniversity of GlasgowGlasgow, Scotland

Barry M. Massie, MDProfessor of MedicineChief, Cardiology DivisionSan Francisco VA Medical CenterUniversity of California, San FranciscoSan Francisco, CA

Christine E. Seidman, MDDirector, Cardiovascular Genetics CenterDepartment of GeneticsHarvard Medical SchoolBrigham and Women’s HospitalBoston, MA

James Shepherd, MB, ChB, PhDProfessorHead of the Department and Honorary Consultant of Vascular BiochemistryRoyal InfirmaryGlasgow, Scotland

Lars Wallentin, MD, PhDProfessor of Cardiology, Department HeadUppsala Clinical Research CenterUppsala, Sweden

Michael A. Weber, MDProfessor of MedicineState University of New York DownstateBrooklyn, NY

John Wilding, DM, FRCPReader in MedicineClinical Sciences CentreUniversity Hospital AintreeLiverpool, England

ELIGIBILITY OF APPLICANTEligible candidates (Young Investigators) with demonstrated experience in basic science or clinical research must be licensed physicians (with or without a

PhD) who have completed medical school within the past 10 years and

1. are currently enrolled in the later years of a cardiology fellowship program

GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease:

International Review Committee

(their first year of funding must be in at least their second year of fellowship)

2. are junior faculty

3. have completed their cardiology specialty training within the past 3 years (international).

If the above criteria are not met, the application will not be accepted for review.

Individuals with R01 grants are not eligible. Accepted candidates may transfer the grant to another institution or research group. Applicants may also continue from a third-year fellowship into a junior faculty position, provided the same study will be continued and receives written consent from the committee.

RESEARCH AREAS Basic science and clinical research will be considered in all cardiovascular therapeutic areas, such as:

Atherosclerosis Dyslipidemia Thrombosis Arrhythmia Hypertension Congestive heart failure Stroke Diabetes

Disciplines in cardiovascular research that will be considered include, but are not restricted to:

Imaging Molecular biology Genetics, genomics Health economics Myocardial metabolism Integrated physiology Rheology of hemodynamics Stem-cell transplantation Visionary research (ie, novel risk factors, database analysis, and

genetic epidemiology)

Instructions for Submission

1. FORMAT

Follow the outlined format stated below Arial or Helvetica font is preferred.

Font sizes smaller than 10 point are not acceptable

All categories must be filled out completely for the application to be considered

If a specific section of the application does not apply to you, please indicate “not applicable.”

2. APPLICATION

Applicant Information Form,This form must be filled out completely and include all pertinent signatures.

Research Advisor InformationThis form must be filled out completely and include the research advisor’s signature. An abbreviated curriculum vitae (CV) of the research advisor is required. We will not accept an addendum with a complete CV. Please utilize the designated form provided to complete this information, or provide the information in similar format in your submitted documents. Provide a list of publications that demonstrates the advisor’s research and expertise in the field being studied by the applicant.

Abstract (1 page)The abstract summarizes the project, and is a succinct and accurate description of the proposed work when separated from the application. State the applications broad, long-term objectives and specific aims, addressing relation to health. Describe the research design and methods for achieving research goals. In a few sentences, describe the relevance to public health.

Key Personnel (1 page)List the names, title, organization, and role on project of key personnel that will be involved in this project. Start with yourself as the principal investigator, then your research advisor, and other key personnel instrumental to its completion. These personnel must devote measurable effort to the project, whether or not salaries are requested. Provide a 1-2 paragraph biosketch of each key person.

Budget (1 page)The grant is intended to be used for salary. If salary is already accounted for, the grant may be applied to other direct research costs. In this section, provide a summary of how your grant is to be used. A stipulation for this grant is that the recipient’s institution may not sequester more than 10% for indirect costs. If the grant is only being used for salary, it is acceptable to state this information only.

Research Plan: Specific Aims (1 page)List the broad, long-term objectives and goals of the specific research proposed.

Research Plan: Background and Significance (3 pages)Briefly review the background that lead to the present application, critically evaluating existing knowledge and specifically identifying gaps that this project is intended to fill. Identify the health relevance by relating to the specific aims and longer term objectives. If the goals of the research are achieved, provide information on how scientific knowledge or clinical practice will be advanced.

Research Plan: Preliminary Studies (3 pages)Review your preliminary work that is applicable to this application. Through this work, demonstrate your experience and competence needed to pursue this project to its completion.

Research Plan: Research Design and Methods (8 pages)Describe the research-design conceptual or clinical framework, procedures, and analyses to be used to accomplish the specific aims of the project. Include how data is to be collected, analyzed, and interpreted. Describe any new methodologies over existing concepts, approaches, tools, or technologies for the proposed project. Describe any difficulties or limitations of the proposed procedures and alternative approaches to achieve these aims. Also, provide a sequence and timetable for the project.

Instructions for Submission

Literature Cited (3 pages)All references listed must conform to AMA style. Each reference must include the title, names of all authors, book or journal volume numbers, and year of publication. The references should be limited to relevant and current literature.

Description of Facility/Resources for Conducting Research (1 page)Describe the facility, laboratory, and resources that are available to you to conduct this research. If special equipment is required, please describe the experience with this equipment to demonstrate competence.

Listing of Active Grants (2 pages)Provide a list of all grants under which you are currently working, and the nature of the project they are funding.

3. RESEARCH ADVISOR LETTER OF RECOMMENDATION

The review committee must receive a letter of recommendation from the candidate’s research advisor, which addresses the research potential for the candidate and the career-development plan. The letter should indicate that the research advisor has reviewed and approved the application. Please note the research advisor should also sign the application on the second page of the form.

4. ADDENDUM

The review committee requires all applicants to provide their complete CV as an addendum. Figures relevant to the research should also be included.

5. SUBMISSION

An electronic version of the application can be downloaded from www.cvfoundation.org in either Adobe Acrobat (PDF) or Microsoft Word format. The following are 3 acceptable ways to submit the completed application. Please utilize only 1 method, unless otherwise requested:

E-mailE-mail the complete application as a Microsoft Word 6.0 or later or as an Adobe Acrobat 6.0 or later format to [email protected]. Applications may include documents in various formats (ie, forms in Adobe Acrobat and all other information in Microsoft Word). All documents and the subject line of the e-mail must be labeled “Your name, Dept 2383.” All required application information must be included in your submission. If you are unable to e-mail your letter of recommendation, please note this in the e-mail and identify which method the letter will be coming under separate cover (ie, fax or mail). Scanned signatures are permitted for forms and letters.

MailMail 1 printout of the completed application to:International Competitive Grants Award Program for Young InvestigatorsScientific Therapeutics Information, Inc, Dept 2383505 Morris Ave, 3rd Floor, Springfield, NJ 07081

FaxFax 1 printout of the completed application to 973-376-0611, attention International Competitive Grants Award Program for Young Investigators, Dept 2383.

6. DEADLINE

Submission deadline is 5:00 PM (US EST) on December 1, 2006.

7. NOTIFICATION AND ANNOUNCEMENT OF WINNERS

Winners of the International Competitive Grants Award Program for Young Investigators will be notified in late January 2007.

8. AWARDS/RESPONSIBILITY OF AWARDEES

All grants will be funded beginning on July 1, 2007, and annually thereafter. Progress reports are due on April 1, 2008 and April 1, 2009. A full research report will be due in September 2009 following the conclusion of the grant period. Details outlining these responsibilities will be forwarded to the grant winners after selection. The grant recipient winners will be honored at a dinner reception during the 56th Annual Scientific Session of the American College of Cardiology Scientific Session in New Orleans on March 24–27, 2007. Further information will be forthcoming.

9. ADDITIONAL APPLICATIONS/QUESTIONS An electronic version of the application can be downloaded from www.cvfoundation.org. If you have any questions or need additional printed copies of the application, please call 973-376-5655 x204 between the hours of 9:00 AM and 5:00 PM EST, or e-mail [email protected].

APPLICATION CHECK

OFF LIST

Before you submit your application, please make certain that the following information is included:

All sections of the application have been completed, or if something does not apply, “not applicable” (N/A) has been indicated

All signatures are complete: you have signed and dated your application, your research advisor has signed and dated your application, and the individual and institutional authorization has been signed and dated.

APPLICATION COMPONENT

S

Please see below for a list of all components that should be included in your application:

Applicant Information Form

Abstract (1 page)

Key Personnel (1 page)

Budget (1 page)

Research Plan: Specific Aims (1 page)

Research Plan: Background and Significance (3 pages)

Research Plan: Preliminary Studies (3 pages)

Research Plan: Research Design and Methods (8 pages)

Literature Cited (3 pages)

Description of Facility/Resources for Conducting Research (1 page)

Listing of Active Grants (2 pages)

Research Advisor Letter of Recommendation

Addendum : Curriculum Vitae and

Relevant Figures

Please note pages listed are

maximum allowable pages.

GlaxoSmithKline Research & Education Foundation for Cardiovascular Disease

“2007 International Competitive Grants Award Program for Young Investigators”

GRANT APPLICATION

TITLE OF PROJECT:

PRINCIPAL INVESTIGATOR INFORMATION

Name/Degree(s): New Investigator: No

Yes

Applicant’s Current Position Title:

Department, Service, Laboratory or Equivalent:

Current Status of Training:

US Applicant Status: Fellow (2nd year or later)

Junior Faculty

Other:

International Applicant Status: Fellowship/cardiology training completed within past 3 years

Junior Faculty

Other:

Applicant Organization Name (Institution):

Applicant Organization Address: Administrative Official to be Notified if Award is

Made:

Street Address (For correspondence - no PO boxes): Name:

Title:

Address:

City:

State/Province/Country:

Postal Code: Phone:

Phone: Fax:

Fax: Email:

Email: Applicant organization certification and acceptance: I certify that the statements herein are true, complete and accurate to the best of my knowledge, and accept the obligation to comply with the terms and conditions if a grant is awarded as a result of this application. I criminal, civil or administrative penalties.

Signature of Applicant Date

Signature of Official named above Date

Please indicate how you were informed of this program:



Research Advisor/Colleague

Foundation web site

Journal Ad Annual meetings: AHA/ESC/ACC

Medical School mailing Other (please specify)

If you wish to obtain an electronic version of this form, go to www.cvfoundation.org.



RESEARCH ADVISOR INFORMATION

Name/Degree(s)

Title/Institution

Street Address (for correspondence - no PO boxes)

City

State/Province/Country:

Postal Code

MD Received From Year

PhD Received From Year

RESEARCH ADVISOR ABBREVIATED CURRICULUM VITAE

Present Position

Prior Position

Mentorship (Scientific)

Courses Organized

Grants Received

Other



Research Advisor Assurance: I certify that the statements herein are true, complete and accurate to the best of my knowledge, and accept the obligation to comply with the terms and conditions if a grant is awarded as a result of this application. I am aware that any false, fictitious or fraudulent statements or claims may subject me to criminal, civil or administrative penalties. I agree to accept responsibility for the scientific conduct of the project and to provide the required progress reports if a grant is awarded as a result of this application.

________________________________________________________________________________________________________________________________________________Signature of Official named above Date



ABSTRACT (1-page)



KEY PERSONNEL (1 page)

Name Organization Role on Project



BUDGET (1 page)

Please describe the allocation of your annual budget. If used for salary, what portion and for whom. If salary is covered, how will funding be used?



RESEARCH PLAN: SPECIFIC AIMS (1 page)



RESEARCH PLAN: BACKGROUND AND SIGNIFICANCE (3 pages)



RESEARCH PLAN: PRELIMINARY STUDIES (3 pages)



RESEARCH PLAN: RESEARCH DESIGN AND METHODS (8 pages)



LITERATURE CITED (3 pages)



DESCRIPTION OF FACILITY/RESOURCES FOR CONDUCTING RESEARCH (1 page)



LISTING OF ACTIVE GRANTS (2 pages)

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Documents